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Dissertations / Theses on the topic 'Malaria research/mouse model'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Gilks, C. F. "The surface of Plasmodium chabaudi infected erythrocytes." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233501.

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2

Watkins, Katherine Ruth. "Investigation of pre-erythrocytic malaria vaccines in a mouse model using transgenic parasites." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534200.

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3

Achtman, Ariel H. "The B cell response to Plasmodium chabaudi chabaudi : malaria in the mouse model." Thesis, Open University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398011.

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4

Min-Oo, Gundula Ellen. "The genetic basis of malaria susceptibility: uncovering novel host factors in a mouse model of blood-stage infection." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66739.

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This thesis examines the genetic factors controlling host response to malaria. Recombinant congenic strains AcB55 and AcB61 were identified as uniquely resistant to malaria despite a susceptible genetic background. These mice display splenomegaly, anemia, reticulocytosis and extra-medullary erythropoiesis. Genome wide mapping led to the identification of a mutation in pyruvate kinase (PklrI90N) that is associated with increased survival and decreased peak parasite levels. We found a significant malaria-protective effect with a second Pklr mutation (PklrG338D) on a distinct ge

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5

Wyse, Ana Paula Pintado. "Optimal control for malaria vector for a seasonal mathematical model." Laboratório Nacional de Computação Científica, 2007. http://www.lncc.br/tdmc/tde_busca/arquivo.php?codArquivo=140.

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In the Amazonian region occurs a variation in the malaria incidence, which is related to the pluviometric variation annual. The mathematical model proposed here considers this seasonality and different treatment intensities accessible to the infected people. The numerical evidence the seasonal fluctuation and the relationship between the environment temperature and treatment efficiency, showing that the temperature increase strongly affects the extrinsic latent period,reducing the healthy care efficiency. Because malaria treatment already exists it should be import. For another hand, even the

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6

Komuro, Yutaro. "Altered adult neurogenesis in a mouse model of human tauopathy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1434743393.

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7

Ohashi, Taryn M. "Eradicating Malaria: Improving a Multiple-Timestep Optimization Model of Malarial Intervention Policy." Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/scripps_theses/273.

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Malaria is a preventable and treatable blood-borne disease whose complications can be fatal. Although many interventions exist in order to reduce the impacts of malaria, the optimal method of distributing these interventions in a geographical area with limited resources must be determined. This thesis refines a model that uses an integer linear program and a compartmental model of epidemiology called an SIR model of ordinary differential equations. The objective of the model is to find an intervention strategy over multiple time steps and multiple geographic regions that minimizes the number o

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8

Huan, Xiang Quan. "Depot cytokines and chemokines for antitumor therapy in a mouse model /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18435.pdf.

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9

Krishnamurthy, Varun K. "Biomechanical and Molecular Approaches to Aortic Valve Disease in a Mouse Model." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1354297165.

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10

Quiggle, David Douglas. "The effects of R-flurbiprofen in reducing tumors in a multiple intestinal neoplasia mouse model." CSUSB ScholarWorks, 2001. https://scholarworks.lib.csusb.edu/etd-project/2009.

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The design of the proposed study was to administer R-FB to 72-day old Min/+ mice for up to 42 days. In order to capture the process of tumor reduction, animals were necropsied at various time points. At each time point animals were evaluated for tumor loads and presence of apoptotic cells along the small intestine. Studies have shown that when R-flurbiprofen (R-FB) is administered in the Min/+ mouse model it can cause the prevention and regression on intestinal tumors.

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11

Habli, Mounira A. M. D. "Recapitulation of Human Placental Insufficiency in a Novel Mouse Model :New Paradigm in Translational Research." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1338582019.

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12

Birget, Philip Laurent Guillaume. "Evolutionary ecology of parasites : life-history traits, phenotypic plasticity, and reproductive strategies." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28805.

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Adaptive phenotypic plasticity, the ability of a genotype to give rise to different phenotypes in different environments, evolves to allow organisms to fine-tune their life-history traits according to the varying conditions they encounter during their lives. Reproductive investment - the manner in which organisms divide their resources between survival and reproduction - is well studied in evolutionary ecology because it is a key determinant of fitness. However, whilst plasticity in reproductive effort is well understood for free-living multicellular taxa (such as insects, birds, and mammals),

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13

Tobias, Lynette. "The pregnant mouse model of brucellosis: the pathology and protection studies comparing Brucella abortus strains 2308, 19 and RB51." Diss., Virginia Tech, 1991. http://hdl.handle.net/10919/39917.

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14

Ward, Brittney M. "Analyzing consequences to astrocytes in a mouse model of brain arteriovenous malformation." Ohio University Honors Tutorial College / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1619298440206905.

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15

Chokalingam, Kumar. "Transgenic Mouse Model: Examination of Healing, Development and Mechanical Response of Cells." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1259076989.

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16

Farr, Tracy Deanne, and University of Lethbridge Faculty of Arts and Science. "A mouse model for studying stroke induced impairments, recovery, and compensation in the motor cortex." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003, 2003. http://hdl.handle.net/10133/156.

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Stroke is the third leading cause of death and survivors suffer motor impairments. The rodent sensorimotor system is similar to the human's, making rodents a good model to study the effects of stroke. Transgenic technology makes the mouse a desirable stroke model, however, there are few behavioural tests to assess behavioural outcome. This thesis evaluates mice subjected to permanent or temporary occlusion focal motor cortex strokes in a skilled reaching task. The first experiment documents changes in skilled movements in mice with a permanent occlusion focal motor cortex stroke. The second ex

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17

Paliobeis, Andrew S. "Effects of Pramlintide on Mitochondrial Dynamics and Health in the Alzheimer's Disease APP/PS1 Mouse Model." Kent State University Honors College / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1494262713896063.

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18

Kennedy, Samantha F. "Possible breakdown of dopamine receptor synergism in a mouse model of Huntington's Disease." ScholarWorks@UNO, 2017. https://scholarworks.uno.edu/td/2415.

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The model of basal ganglia function proposed by Albin, Young and Penney (1989) describes two anatomically independent motor pathways, the direct and indirect. However, under normal conditions striatal dopamine (DA) is required for the expression of motor behavior, and DAergic control of the two pathways (via D1 and D2 receptors, respectively) is dependent on co-activation. We tested for a possible breakdown of D1/D2 synergism using transgenic R6/1 mice bearing the human huntingtin allele (Htt). Motor stereotypy, observed prior to the onset of HD-related symptoms, was rated on a 5-point scale f

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19

Creamer, Michelle. "UVB Exposure and Topical Estrogen Effects on the Development of Skin Cancer in a Pre- and Post-Menopausal Mouse Model." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337631752.

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20

Perlaza, Blanca-liliana. "Analysis of immune responses related to protection against P. Falciparum pre-erythrocytic stages : aotus lemurinus griseimembra as a model for malaria vaccine research." Rouen, 2000. http://www.theses.fr/2000ROUEM008.

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Le paludisme est une des maladies infectieuses les plus meurtrières pour l'homme. Le développement d'un vaccin contre Plasmodium falciparum, l'agent responsable du paludisme léthal, repose sur l'identification des antigènes cibles de mécanismes immuns protecteurs et sur l'utilisation de modèles animaux appropriés pour l'induction et l'étude de tels mécanismes in vivo. Notre laboratoire a identifié et caractérisé une série d'antigènes pré-érythrocytaires de P. Falciparum (LSA1, LSA3, SALSA et STARP). Parmi eux, LSA3 est le plus prometteur du point de vue vaccinal, et ce, dans différents modèles

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21

King, Marie A. "The Humanized Mouse Model: The Study of the Human Alloimmune Response: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/374.

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The transplantation of allogeneic cells and tissues for the treatment of human disease has been a life-saving procedure for many thousands of patients worldwide. However, to date, neither solid organ transplantation nor bone marrow transplantation have reached their full clinical potential. Significant limitations to the advancement of clinical transplantation stem from our current inability to prevent the rejection of allogeneic tissues by the immune system of the host. Similarly, in patients that receive allogeneic bone marrow transplants, we cannot permanently prevent the engrafted immune s

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22

Mercurio, Andrew David. "Effects of Extensive Periosteal Stripping on the Microstructure and Mechanical Properties of Cortical Bone." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306435727.

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23

Tian, Nan. "SLEEP-RELATED GENERALIZED TONIC SEIZURE AND HIGH FREQUENCY OSCILLATION (HFOs) IN A MESIAL TEMPORAL LOBE EPILEPSY MOUSE MODEL." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1277440218.

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24

Durst, Mattea Sophie [Verfasser]. "Evaluating the Pain Management in a Mouse Osteotomy Model - Integrating a Refinement Approach in a Basic Research Study / Mattea Sophie Durst." Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1192755685/34.

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25

Zorko, Nicholas Alexander. "The Role of the Mixed Lineage Leukemia Partial Tandem Duplicationin Acute Myeloid Leukemogenesis." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1374101112.

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26

Kok, Cornelius Wilhelmus. "Molecular characterization of human vaginal mucosa obtained from fresh harvest and implants in an experimental nude mouse model." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6879.

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Thesis (MMedSc )--University of Stellenbosch, 2011.<br>ENGLISH ABSTRACT: The present study investigated in particularly the specific nature of the supporting stromal layer located between the implanted human cyst and host murine tissue, which has yet to be reported. During an initial phase of this study, the particular light microscopic properties of the existing hematoxylin and eosin (H&E) stained experimental cyst was investigated, with regards to the presence or absence of specific morphological features, namely spongiosis, exocytosis, epithelial keratinization, epithelial thickness an

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27

Burke, Steven Russell Alan. "Assessment of In Vivo Muscle Force in the R6/2 Mouse Model of Huntington's Disease Using Newly Designed Force Rig." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1610360658382723.

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28

Gao, Juehua. "Biological functions and molecular mechanisms of the interleukin-4 signaling pathways in autoimmune exocrinopathy using the nod.b10.h2b mouse model of sjogren's syndrome." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0006639.

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Thesis (Ph. D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 152 pages. Includes Vita. Includes bibliographical references.

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29

Henninger, Nils. "Inhibiting Axon Degeneration in a Mouse Model of Acute Brain Injury Through Deletion of Sarm1." eScholarship@UMMS, 2017. http://escholarship.umassmed.edu/gsbs_diss/900.

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Traumatic brain injury (TBI) is a leading cause of disability worldwide. Annually, 150 to 200/1,000,000 people become disabled as a result of brain trauma. Axonal degeneration is a critical, early event following TBI of all severities but whether axon degeneration is a driver of TBI remains unclear. Molecular pathways underlying the pathology of TBI have not been defined and there is no efficacious treatment for TBI. Despite this significant societal impact, surprisingly little is known about the molecular mechanisms that actively drive axon degeneration in any context and particularly followi

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30

Cromwell, Mary A. "The Role of T Lymphocytes in the hu-PBMC-SCID Mouse Model of Epstein-Barr Virus-Associated Lymphoproliferative Disease." eScholarship@UMMS, 1995. https://escholarship.umassmed.edu/gsbs_diss/158.

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Epstein-Barr virus (EBV) is associated with a spectrum of benign and malignant lymphoproliferative disorders, including acute infectious mononucleosis (IM), Burkitt's lymphoma (BL) and immunosuppression-associated B cell lymphoproliferative disease (LPD). Immunosurveillance mediated by virus-specific cytotoxic T lymphocytes is believed to protect immunocompetent hosts from EBV-associated lymphoma and LPD. Due to the lack of an adequate animal model, however, the precise immunologic mechanisms which provide this protection have not been directly demonstrated in vivo. Human peripheral blood mono

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31

Painter, Palak Rajeshkumar. "Quantitative analysis of glycinergic neurons including Ia inhibitory interneurons in the ventral spinal cord using a BAC-GlyT2-eGFP transgenic mouse model." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1347911464.

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32

Golden, Jackelyn B. "Abnormalities in the Adhesion and Aggregation Profiles of Circulating Monocytes in Psoriasis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1441361209.

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33

Akiel, Maaged A. "CHARACTERIZATION OF THE ROLE OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7 (IGFBP7) USING A GENETIC KNOCKOUT MOUSE MODEL." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4695.

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In the US, the incidence and mortality rates of hepatocellular carcinoma (HCC) are alarmingly increasing since no effective therapy is available for the advanced disease. Activation of IGF signaling is a major oncogenic event in diverse cancers, including HCC. Insulin-like growth factor binding protein-7 (IGFBP7) inhibits IGF signaling by binding to IGF-1 receptor (IGF-1R) and functions as a potential tumor suppressor for hepatocellular carcinoma (HCC). IGFBP7 abrogates tumors by inducing cancer-specific senescence and apoptosis and inhibiting angiogenesis. We now document that Igfbp7 knockout

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34

Huettner, Lauren E. "Development and Characterization of Ectromelia Virus-Moscow in the BALB/c Mouse Model for Smallpox Therapeutic and Prophylaxis Drug Efficacy Testing Under the FDA Animal Rule." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397642415.

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35

Balaji, Swathi. "In situ tissue engineering using angiogenic peptide nanofibers to enhance diabetic wound healing." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1291151135.

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36

Dai, Lu. "EFFECTS OF CHROMIUM ON MOUSE SPLENIC T LYMPHOCYTES AND EFFECTS OF ETHANOL EXPOSURE DURING EARLY NEURODEVELOPMENT ON BEHAVIORS IN MICE." UKnowledge, 2017. https://uknowledge.uky.edu/toxicology_etds/18.

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The dissertation consists of three major projects with the focus on the immunotoxicity of chromium and the behavior disorders caused by early ETOH exposure respectively. Hexavalent chromium [Cr(VI)] is widely used in various industrial processes and has been recognized as a carcinogen. As the first line of host defense system, the immune system can be a primary target of Cr(VI). T cell population represents a major arm of the immune system that plays a critical role in host anti-tumor immunity. Dysfunction of T cells compromises host anti-tumor immunity resulting in oncogenesis. Using mouse sp

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37

Wyse, Ana Paula Pintado. "Controle ótimo do vetor da malária para o modelo matemático sazonal." Laboratório Nacional de Computação Científica, 2007. https://tede.lncc.br/handle/tede/69.

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Made available in DSpace on 2015-03-04T18:50:52Z (GMT). No. of bitstreams: 1 Tese_Ana_Wyse.pdf: 2000846 bytes, checksum: 92bfb0c607fa7c1745d9424164c49c63 (MD5) Previous issue date: 2007-04-09<br>Conselho Nacional de Desenvolvimento Cientifico e Tecnologico<br>In the Amazonian region occurs a variation in the malaria incidence, which is related to the pluviometric variation annual. The mathematical model proposed here considers this seasonality and different treatment intensities accessible to the infected people. The numerical evidence the seasonal fluctuation and the relationship between

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38

Smith, Porsha L. "Protein Arginine Methyltransferase 5 as a Driver of Lymphomagenesis." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1468975682.

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39

Toro, Gabriela. "Gene Therapy for Amyotrophic Lateral Sclerosis: An AAV Mediated RNAi Approach for Autosomal Dominant C9ORF72 Associated ALS." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1020.

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Amyotrophic lateral sclerosis (ALS) is a terminal neurodegenerative disease that affects motor neurons causing progressive muscle weakness and respiratory failure. In 2011, the presence of a hexanucleotide repeat expansion within chromosome 9 open reading frame 72(C9ORF72) was identified in ALS patient samples, becoming the major known genetic cause for ALS and frontotemporal dementia (FTD). Carriers of this mutation present reduced levels of C9ORF72 mRNA, RNA foci produced by the aggregating expansion and toxic dipeptides generated through repeat-associated non-ATG translation. These findings

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40

Nun, Nicholas. "Improving Skin Wound Healing Using Functional Electrospun Wound Dressings and 3D Printed Tissue Engineering Constructs." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1617985844538101.

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41

Chambers-Turner, Ruth C. "The IM-9 cell line: a model for evaluating TCDD-induced modulation of the polymorphic human hs1,2 enhancer within the 3' immunoglobulin heavy chain regulatory region." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1269027538.

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42

Smith, Jordan L. "Reversing Cancer Cell Fate: Driving Therapeutic Differentiation of Hepatoblastoma to Functional Hepatocyte-Like Cells." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1067.

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Background & Aims: Despite advances in surgical care and chemotherapeutic regimens, the five-year survival rate for Stage IV Hepatoblastoma (HB), the predominant pediatric liver tumor, remains at 27%. YAP1 and β-Catenin co-activation occurs in 80% of children’s HB; however, a lack of conditional genetic models precludes exploration of tumor maintenance and therapeutic targets. Thus, the clinical need for a targeted therapy remains unmet. Given the predominance of YAP1 and β-catenin activation in children’s tumors, I sought to evaluate YAP1 as a therapeutic target in HB. Approach & Results: Her

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43

"Mouse orthotopic model for therapeutic bladder cancer research." 2014. http://library.cuhk.edu.hk/record=b6116078.

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Objectives: To establish a mouse orthotopic bladder cancer model with consistent tumor-take rate. This orthotopic model was subsequently used to evaluate small animal imaging techniques and investigate new therapeutic agents for bladder cancer treatment.<br>Materials and Methods: Different orthotopic implantation techniques have been tested. MBT-2 cells and syngeneic C3H/He mice were used in all experiments. Chemical bladder pre-treatment with different agents (saline, hydrochloric acid, trypsin and poly-L-lysine) and different concentration of instilled tumor cells (1 x 10⁶ or 2 x 10⁶) were i

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44

Abeysekera, Irushi Shamalka. "Effect of Epigallocatechin-3-gallate on Skeletal and Cognitive Phenotypes in a Down Syndrome Mouse Model." Thesis, 2014. http://hdl.handle.net/1805/5628.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Down syndrome (DS), a genetic disorder that affects ~1 in 700 live births, is caused by trisomy of human chromosome 21 (Hsa21). Individuals with DS are affected by a wide spectrum of phenotypes which vary in severity and penetrance. However, cognitive and skeletal impairments can be commonly observed in all individuals with DS. To study these phenotypes, we utilized the Ts65Dn mouse model that carries three copies of approximately half the gene orthologs found on Hsa21 and exhibit similar phenotypes as observed in humans with DS. Ind

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45

Stringer, Megan Elizabeth. "Effect of Epigallocatechin-3-gallate on a pattern separation task and hippocampal neurogenesis in a mouse model of Down syndrome." Thesis, 2015. http://hdl.handle.net/1805/10037.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Down syndrome (DS) is caused by three copies of human chromosome 21 (Hsa21) and results in an array of phenotypes including intellectual disability. Ts65Dn mice, the most extensively studied DS model, have three copies of ~50% of the genes on Hsa21 and display many phenotypes associated with DS, including cognitive deficits. DYRK1A is found in three copies in humans with Trisomy 21 and in Ts65Dn mice, and is involved in a number of critical pathways including CNS development and osteoclastogenesis. Epigallocatechin-3-gallate (EGCG)

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46

Deitz, Samantha L. "Molecular Basis and Modification of a Neural Crest Deficit in a Down Syndrome Mouse Model." 2013. http://hdl.handle.net/1805/3354.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Down syndrome (DS) is the result of trisomy of human chromosome 21 (Hsa 21) and occurs in approximately 1/700 live births. Mouse models of DS have been crucial in understanding the gene-phenotype relationships that underlie many DS anomalies. The Ts65Dn mouse model, trisomic for half of the Hsa 21 orthologs replicates many DS phenotypes including craniofacial alterations such as a small, dysmorphic mandible, midface, and maxilla. Other mouse models, such as the Ts1Rhr which contains a triplication of 33 Hsa 21 orthologs, have been us

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47

Jurado, Jiménez Ángeles [Verfasser]. "Role of the co-inhibitory molecule PD-1 (CD279) and its ligand PD-L1 (CD274) in a mouse (Mus musculus; Linnaeus, 1758) model of malaria / submitted by Ángeles Jurado Jiménez." 2009. http://d-nb.info/998103292/34.

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48

Knowles, Kellen A. "Adipose stromal cells enhance keratinocyte survival and migration in vitro, and graft revascularization in mouse wound healing model." Thesis, 2013. http://hdl.handle.net/1805/3752.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>In the US, more than 1 million burn injuries are reported annually. About 45,000 injuries due to fires and burns result in hospitalization and ten percent of these result in death every year. Advances in burn treatment have led to a reduction in mortality rate over the last decades. Since more patients are surviving the initial resuscitation phase even with very large areas of skin being burned away, wound care has become increasingly important to ensure continued patient survival and improvement. While currently a common treatment f

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49

Rhodes, Steven David. "Dissecting the cellular and molecular mechanisms mediating neurofibromatosis type 1 related bone defects." Thesis, 2014. http://hdl.handle.net/1805/3793.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Skeletal manifestations including short stature, osteoporosis, kyphoscoliosis, and tibial dysplasia cumulatively affect approximately 70% of patients with neurofibromatosis type 1 (NF1). Tibial pseudarthrosis, the chronic non-union of a spontaneous fracture, is a debilitating skeletal malady affecting young children with NF1. These non-healing fractures respond poorly to treatment and often require amputation of the affected limb due to limited understanding of the causative mechanisms. To better understand the cellular and molecula

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50

Knoch, Bianca. "The effects of dietary eicosapentaenoic acid and arachidonic acid on gene expression changes in a mouse model of human inflammatory bowel diseases : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Nutritional Science at Massey University, Palmerston North, New Zealand." 2010. http://hdl.handle.net/10179/1529.

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Nutrigenomics studies the genome-wide influence of nutrients to understand the association between nutrition and human health. Studies in animal models and humans have demonstrated that dietary n-3 polyunsaturated fatty acids (PUFA) from fish oil may be beneficial in inflammatory bowel diseases (IBD). This thesis aimed to test the hypothesis that dietary n-3 PUFA eicosapentaenoic acid (EPA) reduced and n-6 PUFA arachidonic acid (AA) increased colitis in the interleukin- 10 gene-deficient (Il10–/–) mouse model of IBD, and that these PUFA altered the intestinal bacteria community during colitis

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