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1

McCann, Michael L. Prescription for Health: Healthy RX for Prevention, Maintenance and Recovery. Lanham, MD, USA: Pneuma Life Publishing, 2002.

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2

Green, Mark. Compromising your drug of choice: How HMOs are dictating your next prescription. New York, NY: [New York Public Advocate's Office], 1996.

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3

Scanlon, William. Prescription drug benefits: Impact of Medicare HMOs' use of formularies on beneficiaries : statement of William J. Scanlon, Director, Health Financing and Public Health Issues, Health, Education, and Human Services Division, before the Special Committee on Ag. Washington, D.C: The Office, 1999.

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4

Office, General Accounting. Prescription drug benefits: Implications for beneficiaries of medicare HMO use of formularies : report to Congressional Requesters. Washington, D.C. (P.O. Box 37050, Washington, D.C. 20013): U.S. General Accounting Office, 1999.

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5

Insurance, California Legislature Senate Committee on. Informational hearing on how can the state protect senior citizens from dwindling prescription drug benefits? Sacramento, Calif: Senate Publications, 2000.

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6

California. Legislature. Senate. Committee on Insurance. Informational hearing on how can the state protect senior citizens from dwindling prescription drug benefits? Sacramento, CA (1020 N Street, Sacramento): Additional copies, Senate Publications, 2000.

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7

California. Bureau of State Audits. Department of Health Services: Its drug management techniques are similar to those of health maintenance organizations. Sacramento, Calif: Bureau of State Audits, 1997.

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8

Incorporated, CCH, ed. Medicare part D: Medicare prescription drug benefit : January 28, 2005 : including CCH explanations and new and revised regulations from 42 C.F.R. parts 400, 403, 411, 417, and 423. Chicago: CCH, 2005.

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9

Office, General Accounting. Medicare+Choice: Plan withdrawals indicate difficulty of providing choice while achieving savings : report to Congressional Requesters. Washington, D.C. (P.O. Box 37050, Washington, D.C. 20013): The Office, 2000.

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10

Office, General Accounting. Medicare+choice: New standards could improve accuracy and usefulness of plan literature : report to Congressional requesters. Washington, D.C. (P.O. Box 37050, Washington, D.C. 20013): The Office, 1999.

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11

Office, General Accounting. Medicare+Choice: Recent payment increases had little effect on benefits or plan availability in 2001 : report to Congressional requesters. Washington, D.C: U.S. General Accounting Office, 2001.

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12

Office, General Accounting. Medicare+Choice: Oversight lapses in HCFA's review of Humana's 1998 Florida contract. Washington, DC: GAO, United States General Accounting Office, 2000.

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13

Office, General Accounting. Medicare+Choice: Payments exceed cost of fee-for-service benefits, adding billions to spending : report to Congressional requesters. Washington, D.C. (P.O. Box 37050, Washington, D.C. 20013): The Office, 2000.

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14

Office, General Accounting. Medicaid: States' efforts to educate and enroll beneficiaries in managed care. Washington, D.C: The Office, 1996.

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15

Office, General Accounting. Medicaid: States turn to managed care to improve access and control costs : report to the Chairman, Subcommittee on Oversight and Investigations, Committee on Energy and Commerce, House of Representatives. Washington, D.C: The Office, 1993.

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16

Office, General Accounting. Medicaid: Changes in best price for outpatient drugs purchased by HMOs and hospitals : fact sheet for the Chairman, Subcommittee on Regulation, Business Opportunities, and Technology, Committee on Small Business, House of Representatives. Washington, D.C: The Office, 1994.

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17

Office, General Accounting. Medicaid: Data improvements needed to help manage health care program : report to the Honorable Daniel K. Inouye, U.S. Senate. Washington, D.C: U.S. General Accounting Office, 1993.

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18

Office, General Accounting. Medicaid: Tennessee's program broadens coverage but faces uncertain future : report to the Ranking Minority Member, Committee on Commerce, House of Representatives. Washington, D.C: The Office, 1995.

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19

Office, General Accounting. Medicaid: Outpatient drug costs and reimbursements for selected pharmacies in Illinois and Maryland : fact sheet for Congressional committees. Washington, D.C: U.S. General Accounting Office, 1993.

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20

Office, General Accounting. Medicaid: Methods for setting nursing home rates should be improved : report to the Secretary of Health and Human Services. Washington, D.C: GAO, 1986.

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21

Office, General Accounting. Medicaid: Restructuring approaches leave many questions : report to the Chairman, Committee on the Budget, House of Representatives. Washington, D.C: The Office, 1995.

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22

United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Oversight and Investigations., ed. Medicaid: States turn to managed care to improve access and control costs : report to the Chairman, Subcommittee on Oversight and Investigations, Committee on Energy and Commerce, House of Representatives. Washington, D.C: The Office, 1993.

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23

Office, General Accounting. Medicaid: Methods for setting nursing home rates should be improved : report to the Secretary of Health and Human Services. Washington, D.C: The Office, 1986.

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24

Office, General Accounting. Medicaid: States' efforts to educate and enroll beneficiaries in managed care : report to the Chairman, Special Committee on Aging, U.S. Senate. Washington, D.C: The Office ; Gaithersburg, Md. (P.O. Box 6015, Gaithersburg 20884-6015) : The Office [distributor, 1996.

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25

Office, General Accounting. Medicaid: Oregon's managed care program and implications for expansions : report to the Chairman, Subcommittee on Health and the Environment, Committee on Energy and Commerce, House of Representatives. Washington, D.C: The Office, 1992.

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26

Office, General Accounting. Medicaid: The Texas disproportionate share program favors public hospitals. Washington, D.C: U.S. General Accounting Office, 1993.

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27

Office, General Accounting. Medicaid: Methods for setting nursing home rates should be improved : report to the Secretary of Health and Human Services. Washington, D.C: The Office, 1986.

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28

Office, General Accounting. Medicaid: Tennessee's program broadens coverage but faces uncertain future : report to the ranking minority member, Committee on Commerce, House of Representatives. Washington, D.C: The Office, 1995.

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29

Office, General Accounting. Medicaid: Three states' experiences in buying employer-based health insurance : report to the Chairman, Committee on Commerce, House of Representatives. Washington, D.C: The Office, 1997.

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30

Office, General Accounting. Medicaid: Elevated blood lead levels in children : report to the Ranking Minority Member, Committee on Government Reform and Oversight, House of Representatives. Washington, D.C. (P.O. Box 37050, Washington, D.C. 20013): The Office, 1998.

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31

Office, General Accounting. Medicaid: Lessons learned from Arizona's prepaid program : report to the Secretary of Health and Human Services. Washington, D.C: The Office, 1987.

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32

Office, General Accounting. Medicaid: Three states' experiences in buying employer-based health insurance : report to the chairman, Committee on Commerce, House of Representatives. Washington, D.C: The Office, 1997.

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33

Office, General Accounting. Medicaid: Waiver program for developmentally disabled is promising but poses some risks : report to Congressional requesters. Washington, D.C: The Office, 1996.

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34

Office, General Accounting. Medicaid: HealthPASS : an evaluation of a managed care program for certain Philadelphia recipients : report to the Chairman, Subcommittee on Health and the Environment, Committee on Energy and Commerce, House of Representatives. Washington, D.C: U.S. General Accounting Office, 1993.

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35

United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Oversight and Investigations., ed. Medicaid: States turn to managed care to improve access and control costs : report to the Chairman, Subcommittee on Oversight and Investigations, Committee on Energy and Commerce, House of Representatives. Washington, D.C: The Office, 1993.

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36

Office, General Accounting. Medicaid: Sustainability of low 1996 spending growth is uncertain : report to the Chairman, Committee on the Budget, U.S. Senate, and to the Chairman, Committee on the Budget, House of Representatives. Washington, D.C: The Office, 1997.

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37

Office, General Accounting. Medicaid: Restructuring approaches leave many questions : report to the Chairman, Committee on the Budget, House of Representatives. Washington, D.C: The Office, 1995.

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38

Office, General Accounting. Medicaid: Legislation needed to improve collections from private insurers : report to the chairman, Subcommittee on Health and the Environment, Committee on Energy and Commerce, House of Representatives. Washington, D.C: GAO, 1990.

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39

Lubowitz, Sydnie. METHAD0NE: A Prescription Drug Used for Maintenance Treatment of Opioid Addiction. Independently Published, 2019.

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40

(Editor), Felix Gutzwiller, and Thomas Steffen (Editor), eds. Cost-Benefit Analysis of Heroin Maintenance Treatment (Medical Prescription of Narcotics, Vol. 2). S. Karger Publishers (USA), 1999.

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41

Prescription drug benefits: Implications for beneficiaries of Medicare HMO use of formularies : report to congressional requesters. Washington, D.C: The Office, 1999.

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42

Souza, Dmitri, Denis Snegovskikh, and Julia K. Hunter. Patients with Substance Abuse and Chronic Pain. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190271787.003.0032.

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Abstract:
Treating chronic pain in patients with a substance abuse history is challenging. Patients abusing opioids may have a high pain tolerance, making pain control difficult. Available treatments for acute pain include regional and multimodal analgesia. Non-opioid and nonpharmacological analgesia (including interventional modalities, physical rehabilitation, chiropractic manipulations, and pain psychology) can be used to treat chronic pain. Patients’ past and present opioid use—illicit drug or nonmedical prescription opioid use, maintenance on medication-assisted treatment, or abstinence—should be taken into consideration when choosing between chronic pain treatments. Consultation with an addictionologist can facilitate this population’s successful treatment.
43

Wójcik-Gładysz, Anna. Ghrelin – hormone with many faces. Central regulation and therapy. The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 2020. http://dx.doi.org/10.22358/mono_awg_2020.

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Discovered in 1999, ghrelin, is one of the peptides co-creating the hypothalamicgastrointestinal axis, otherwise known as the brain-gut axis. Ghrelin participates in many physiological processes and spectrum of its activity is still being discovered. This 28 amino acid peptide ‒ a product of the ghrl gene, was found in all vertebrates and is synthesized and secreted mainly from enteroendocrine X/A cells located in the gastric mucosa of the stomach. Expression of the ghrelin receptor has been found in many nuclei of the hypothalamus involved in appetite regulation. Therefore it’s presumed that ghrelin is one of the crucial hormones deciphering the energy status required for the maintenance of organism homeostasis. Ghrelin acts as a signal of starvation or energy insufficiency and its level in plasma is reduced after the meal. Neuropeptide Y (NPY) and agouti-related peptide (AgRP; NPY/AgRP) neurons located in the arcuate nucleus (ARC) area are the main target of ghrelin in the hypothalamus. This subpopulation of neurons is indispensable for inducing orexigenic action of ghrelin. Moreover ghrelin acting as a neurohormone, mainly in the hypothalamus area, plays an important role in the regulation of growth and reproduction processes. Indeed, ghrelin action on reproductive processes has been observed in the systemic effects exerted at both hypothalamus-pituitary and gonadal levels. Similarly the GH-releasing ghrelin action was observed both on the hypothalamus level and directly on the somatotrophic cells in the pituitary and this dose-related GH releasing activity was found in in vitro as well as in in vivo experiments. In recent years, numerous studies revealed that ghrelin potentially takes part in the treatment of diseases associated with serious disturbances in the organism energy balance and/or functioning of the gastrointestinal tract. It was underlined that ghrelin may be a hormone with a broad spectrum of therapeutic effect on obesity and anorexia nervosa, as well as may also have protective effect on neurodegenerative diseases, inflammatory disorders or functional changes in the body caused by cancers. In overall, ghrelin treatment has been tested in over 100 preclinical studies with healthy volunteers as well as patients with various types of cancer, eating disorders such as anorexia nervosa and bulimia nervosa. It was observed that ghrelin has an excellent clinical safety profile and emerging side effects occurred only in 3–10% of patients and did not constitute a sufficient premise to discontinue the therapy. In general, it can be concluded that ghrelin may be sufficiently used as a prescription drug.
44

Medicaid: HealthPASS : an evaluation of a managed care program for certain Philadelphia recipients : report to the Chairman, Subcommittee on Health and the Environment, Committee on Energy and Commerce, House of Representatives. Washington, D.C: The Office, 1993.

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45

Medicaid: HealthPASS : an evaluation of a managed care program for certain Philadelphia recipients : report to the Chairman, Subcommittee on Health and the Environment, Committee on Energy and Commerce, House of Representatives. Washington, D.C: The Office, 1993.

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46

Medicaid: Three states' experiences in buying employer-based health insurance : report to the chairman, Committee on Commerce, House of Representatives. Washington, D.C: The Office, 1997.

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47

Medicaid: Changes in drug prices paid by HMOs and hospitals since enactment of rebate provisions : report to congressional committees. Washington, D.C: The Office, 1993.

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48

Medicaid: The Texas disproportionate share program favors public hospitals. Washington, D.C: The Office, 1993.

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49

Medicaid: Alternatives for improving the distribution of funds to states : fact sheet for Congressional requesters. Washington, DC: The Office, 1993.

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50

Medicaid: HealthPASS : an evaluation of a managed care program for certain Philadelphia recipients : report to the Chairman, Subcommittee on Health and the Environment, Committee on Energy and Commerce, House of Representatives. Washington, D.C: The Office, 1993.

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