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Academic literature on the topic 'MagCAD'

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Published: 14 March 2023

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Journal articles on the topic "MagCAD"

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Soldatova, Kristina I., Oleg Ivanovich Kit, Roman E. Tolmakh, Liubov Yu Vladimirova, and Denis S. Kutilin. "Cancer-testis gene-expression features in various tumors." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e14260-e14260. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e14260.

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e14260 Background: Cancer-testis antigens (CTA) can be an effective target for immunotherapy. Immunotherapeutic approaches targeting CTA in breast cancer (BC), endometrial cancer (EC), ovarian cancer (OC), and colon cancer (CRC) are in the incipient stages of development. The purpose of our study was screening of CTA specific for BC, EC, OC and CRC, based on an analysis of transcriptional profiles of CT-genes. Methods: Tumor and intact tissues of the breast, uterus, ovaries and colon were studied in 35, 30, 20 and 60 patients, respectively. RNAs were isolated using the method described by Chomczynski and Sacchi (2006). The REVERTA-L reagent kit was used for the cDNA synthesis. Relative expression of 16 genes ( MAGEA1, MAGEA2, MAGEA3, MAGEA4, MAGEB1, MAGEB2, GAGE1, GAGE3, GAGE4, MAGEC1, BAGE, XAGE3, NYESO1, SSX2, SCP1, PRAME1) was determined by Real-Time qPCR (with GAPDH and GUSB as reference genes). Statistical analysis was performed using the Mann-Whitney test. Results: BC patients showed significantly (p < 0.005) increased expression of MAGEA3, MAGEA4 and GAGE3 in tumor tissues compared to normal ones; EC patients - significantly (p < 0.05) increased expression of MAGEA1, MAGEA2, MAGEA4, MAGEB2, GAGE3, NY-ESO1, SCP1 and PRAME1 in tumor tissues compared to normal ones; OC patients - significantly (p < 0.05) increased expression of MAGEB1, MAGEB2, GAGE1, NY-ESO1 and decreased expression of MAGEA3, MAGEA4, GAGE3, GAGE4, XAGE3, SSX2, SCP1 and PRAME1; CRC patients - significantly (p < 0.05) increased expression of SSX2 and PRAME1, together with decreased BAGE expression, in tumors compared to normal tissues. Conclusions: Analysis of the transcriptional activity of CT-genes revealed the most common diagnostic markers and immunotherapeutic targets for every malignancy: in BC - MAGEA3, MAGEA4 and GAGE3, in EC - MAGEA1, MAGEA2, MAGEA4, MAGEB2, GAGE3, NY-ESO1, SYCP1 and PRAME1, in OC - MAGEB1, MAGEB2, GAGE1 and NY-ESO, in CRC - SSX2 and PRAME1.
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Andrade, Valéria C. C., André L. Vettore, Manuella S. S. Almeida, José S. R. Oliveira, Maria de Lourdes L. F. Chauffaille, Mihoko Yamamoto, Adagmar Andriolo, et al. "Prognostic Impact of Cancer Testis Antigens Expression in Advanced Stage Multiple Myeloma Patients." Blood 110, no. 11 (November 16, 2007): 4733. http://dx.doi.org/10.1182/blood.v110.11.4733.4733.

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Abstract Background: Cancer testis antigens have become the most extensively studied antigen group in the field of tumor immunology. Aims: This study aims to analyze global expression of 14 CT (cancer/testis) antigens in MM to identify possible prognostic markers and therapeutic targets. Patients and Methods: The expression of MAGEA1, MAGEA2, MAGEA3/6, MAGEA4, MAGEA10, MAGEA12, BAGE1, MAGEC1/CT7, GAGE family, LAGE-1, PRAME, NY-ESO-1, SPA17 and SSX1 was studied by RT-PCR in: 15 normal tissues, one pool of 10 normal bone marrow samples, three normal tonsils and bone marrow aspirates from six normal donors, three monoclonal gammophaties of undetermined significance (MGUS), five solitary plasmacytomas, 39 MM samples (95% advanced stage) and MM cell line U266. CodeLink Human UniSet I Bioarrays 10,000 genes was used for arrays analyses. Results: SPA17 was positive in all normal tissues and was excluded for further analyses. MAGEC1/CT7 was positive in bone marrow aspirates from one MGUS and in one plasmacytoma. U266 cell line was positive for all CT antigens, except SSX1. The frequencies of CT antigens expression in MM patients were: MAGEC1/CT7 = 30/39 (77%); LAGE-1 = 19/39 (49%); MAGEA3/6 = 16/39 (41%); MAGEA2 = 14/39 (36%); GAGE family = 13/39 (33%); NY-ESO-1 = 13/39 (33%); BAGE-1 = 12/39 (28%); MAGEA1 = 10/39 (26%); PRAME = 9/39 (23%); SSX-1 = 10/39 (26%); MAGEA12 = 8/39 (20.5%); MAGEA4 and MAGEA10 = 0%. Cox’s regression model showed that GAGE family positivity and number of positive CT antigens > 6 were independent prognostic factors when all patients were analyzed. However, MAGEC1/CT7 expression was the only independent prognostic factor when non-transplanted patients where analyzed. Three samples predominantly positive (> 6) and three samples predominantly negative (0 or 1) for the 13 analyzed CT antigens were submitted to microarrays analyses. 147 genes were overexpressed in predominantly positive CT antigens samples. Conclusions: Based on our findings, MAGEC1/CT7, MAGEA3/6 and LAGE-1 seem good candidates for immunotherapy, since together they are overexpressed in 85% of our MM cases. Besides, GAGE family expression, number of CT antigens > 6 and MAGEC1/CT7 seem to have impact on MM prognosis. Also, the results of arrays analyses corroborate the hypothesis that MM can be separate in two groups: predominantly positive and predominantly negative for CT antigens, meaning that these antigens may have important role for MM biology.
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Kutilin, D. S., and Kh A. Mogushkova. "EFFECT OF ANTHRACYCLINE ANTITUMOR ANTIBIOTICS UPON TRANSCRIPTION ACTIVITY OF CANCER-TESTIS ANTIGENS IN MODEL EXPERIMENTS WITH HeLa CELLS." Medical Immunology (Russia) 21, no. 3 (July 13, 2019): 539–46. http://dx.doi.org/10.15789/1563-0625-2019-3-539-546.

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Cancer-testis antigens (CTA) can be used as a target for immunotherapy of various malignant tumors, including cervical cancer. However, immunotherapy is often used in combination with anthracycline chemotherapy, in particular, doxorubicin (DXR). Their effects upon expression of CTA genes have not been yet studied. Therefore, we studied the effects of doxorubicin at different concentrations and exposure time upon transcriptional profile of 17 cancer-testicular (CT) genes of HeLa CCL-2 cells. A long-term line of human cervical cancer cells (HeLa CCL-2 line) was used in this work. Culturing of HeLa CCL-2 cells was carried out in sterile culture flasks with adhesive surface and ventilated lids at 5% CO2, and 95% humidity at 37 °C, in RPMI-1640 medium with 10% fetal bovine serum, supplied with gentamicin (50 μg/ml), and different concentrations of doxorubicin: 0 μg/ml (control), 2 μg/ml, and 4 μg/ml. Expression levels of 16 RT-genes were determined by quantitative RT-PCR using a Bio-Rad CFX96 thermal cycler. Normalization of results was performed against a reference gene, and expression of tested genes in the control samples. We have found that the time of in vitroexposure, and concentration of doxorubicin exert a significant influence upon expression ofMAGEA1, MAGEA3, MAGEA4, MAGEB1, MAGEB2, GAGE1, GAGE3, BAGE, CTAG1B, XAGE3, NY-ESO1, PRAME1andSYCP1genes, however, without affecting theSSX2, MAGEA2, GAGE4andMAGEC1expression, and DXR concentration as a single factor did not affectMAGEB1andMAGEB2expression. Time of response to DXR effects enabled us to discern early cancer testicular genes with increased expression (MAGEA1, MAGEA3, MAGEA4, NY-ESO1, SYCP1), reduced expression (GAGE1andBAGE), and late inducible testicular genes (GAGE3andXAGE3). These results must be taken into account when carrying out immunotherapy based on the dendritic-cell vaccine technology.
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Riente, Fabrizio, Umberto Garlando, Giovanna Turvani, Marco Vacca, Massimo Ruo Roch, and Mariagrazia Graziano. "MagCAD: Tool for the Design of 3-D Magnetic Circuits." IEEE Journal on Exploratory Solid-State Computational Devices and Circuits 3 (December 2017): 65–73. http://dx.doi.org/10.1109/jxcdc.2017.2756981.

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Zewdu, Eden B., Rachel M. Gonzalez, Yan Ma, Derek Ling, Xiaomin Hu, Qi Ren, Ranran Zhang, et al. "Abstract 2803: A renewable IHC control tool CytoSections࣪ for defining MAGEA3, MAGEA4, and MAGEA9 antibody specificity." Cancer Research 82, no. 12_Supplement (June 15, 2022): 2803. http://dx.doi.org/10.1158/1538-7445.am2022-2803.

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Abstract Melanoma-associated antigen gene A (MAGEA) family proteins are expressed in a variety of tumors with each MAGEA protein having unique roles in cancer pathogenesis. The MAGEA members lack of expression in normal tissue and their role in cancer make them well suited for targeted cancer immunotherapy. Thus, knowing which MAGEA protein expression exists in a tumor is important. However, the MAGEA family shares sequence similarity that makes it difficult to find antibodies that are specific to just one family member. It is also challenging to source tissue generally with HIPAA regulation and even more so to get tissue representation of all 12 MAGEA family members. Here we present CytoSections as an alternative to patient control tissues. CytoSections are formalin fixed, paraffin embedded (FFPE) section of over-expression cell pellets. These cells were transfected with expression plasmids coding for genes of individual MAGES family. In this study, CytoSections are used to screen antibodies to all 12-member MAGEA family of proteins. The MAGEA family members were initially shown positive by targeted protein expression in western and immunohistochemistry using DDK tag antibody. Then multiple MAGEA3, MAGEA4, MAGEA9 antibodies were assessed by IHC to determine their specificity to their intended target. Using MAGEA family as a pilot project, we show that CytoSections is a verified, reproducible, and renewable alternative to human control tissues and serves as an ideal tool for antibody specificity assessment. Citation Format: Eden B. Zewdu, Rachel M. Gonzalez, Yan Ma, Derek Ling, Xiaomin Hu, Qi Ren, Ranran Zhang, Li-Hui Lei, Krishnan Allampallam, Dezhong Yin, Xuan Liu, Wei Fu. A renewable IHC control tool CytoSections࣪ for defining MAGEA3, MAGEA4, and MAGEA9 antibody specificity [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2803.
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Gerdemann, Ulrike, Anne S. Christin, Conrad Russell Cruz, Carlos A. Ramos, Donald R. Shaffer, Stephen Gottschalk, Helen E. Heslop, et al. "Broad Spectrum Tumor Antigen-Specific Cytotoxic T Lymphocytes (CTL) for Therapy of Hematological Malignancy." Blood 114, no. 22 (November 20, 2009): 4083. http://dx.doi.org/10.1182/blood.v114.22.4083.4083.

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Abstract Abstract 4083 Poster Board III-1018 Tumor immunotherapy using cytotoxic T lymphocytes (CTLs) can effectively treat EBV-associated tumors such as Hodgkin's Lymphoma (HL). To extend the benefit of CTL therapy to other non-viral associated tumors we have now developed a means of generating CTLs that recognize a wide spectrum of non-viral tumor-associated antigens (TAA) expressed on a range of hematological malignancies, including Survivin, MAGEA4, Synovial sarcoma X (SSX2), WT1, Prame, Proteinase 3 (PR3), as well as TAAs such as Alpha-fetoprotein (AFP), MAGEA1 and MAGEA3, which are expressed on solid tumors. The generation of TAA-CTL is complicated by the low frequency of circulating reactive T cells which are often anergized or tolerized. We therefore assessed the potency of different cytokine combinations to overcome T cell anergy. The cytokines tested were Th1 polarizing (IL12, IL18, IL27), pro-survival/-proliferative (IL7, IL15, IL4), and Treg inhibitory (IL-6). We first used autologous dendritic cells (DCs) pulsed with overlapping peptide libraries (pepmixes) spanning the different antigens to stimulate T cells in the presence of the optimal cytokine combination. To further optimize the potency of this approach we chose to use combinations of antigens to produce multi TAA-CTL. The use of pepmixes spanning entire antigens as a stimulus both increases the range of suitable patient HLA polymorphisms beyond those matched to individual peptide epitopes and to reduce the risk of tumor immune evasion that is often observed when single defined-epitope TAA peptides are used as a stimulus. Antigen combinations were chosen based on their tumor expression profile; e.g. to target lymphoma we grouped SSX2, Survivin, and MAGEA4, for leukemia we targeted WT1, Prame, PR3, and Survivin and for hepatocellular carcinoma we combined MAGEA1, MAGEA3 and AFP. Using lymphoma as a model system we were consistently able to generate TAA CTL directed against SSX2, Survivin, and MAGEA4 (n=6 healthy donors). The lines were polyclonal comprising CD4+ (mean 57+/-7%) and CD8+ (mean 40+/-16%) T cells, and showed reactivity against SSX2 (median 345 spot forming units (SFU)/1×106 CTL, range 20-4065), Survivin (median 290 SFU/1×106 CTL, range 30-4632.5) and MAGEA4 (median 255 SFU/1×106 CTL, range 27.5-2962.5), using the relevant pepmixes as a stimulus in ELIspot assays. The CTL were also cytolytic against autologous pepmix-pulsed targets; SSX2 (mean 53+/- 32% specific lysis) and Survivin (30%) at an effector:target (E:T) ratio of 40:1, as well as against whole antigen-expressing targets (30% killing of fibroblasts expressing Survivin from a retrovirus vector, E:T 100:1) with no recognition of non-transduced control targets (9%). For leukemia we generated CTL lines with reactivity against WT1 (mean 733 SFU/1×106 CTL +/-88), Prame (mean 555 SFU/1×106 CTL +/-326), PR3 (mean 145 SFU/1×106 CTL +/-156), and Survivin (mean 32 SFU/1×106 CTL +/-25), n=2. We were similarly successful in generating multi TAA-CTL targeting hepatocellular carcinoma with reactivity for MAGEA1, MAGEA3 and AFP (mean 740+/-969, 929+/-624, 163+/-117 SFU/1×106 CTL, respectively), (n=2). These multi TAA-CTL were generated using pepmixes, which may not be well suited to clinical use. To more accurately target tumors expressing naturally processed antigens, we reproduced these experiments using DCs nucleofected with tumor antigen-encoding DNA plasmids. Using this approach we were consistently able to generate polyclonal SSX2- and MAGEA4-specific T cells. Production of Survivin-reactive cells required a plasmid encoding a Survivin-ubiquitin fusion protein to enhance proteosomal processing, degradation and subsequent presentation. By significantly increasing expression of CD70 on DCs [from median 23.4% (range 13.3-48.8) to median 61.9% (range 46.7-83.8)], (p=0.025) using nucleofection (n=4), we could also enhance the production of in vitro expanded MAGEA3-specific T-cells (from 822 SFU/1×106 CTL to 2460 SFU/1×106 CTL). Finally, we successfully substituted CD40L activated autologous B-blasts for DCs to reduce the volume of patient blood required and to facilitate the logistics of preparation. This study shows the successful generation of tumor specific CTL lines targeting multiple tumor antigens simultaneously to reduce the risk of tumor immune escape and describes a technology feasible for clinical application targeting a broad spectrum of hematologic malignancies. Disclosures: No relevant conflicts of interest to declare.
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Fain, Jean S., Aurélie Van Tongelen, Axelle Loriot, and Charles De Smet. "Epigenetic Coactivation of MAGEA6 and CT-GABRA3 Defines Orientation of a Segmental Duplication in the Human X Chromosome." Cytogenetic and Genome Research 159, no. 1 (2019): 12–18. http://dx.doi.org/10.1159/000502933.

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The human genome harbors many duplicated segments, which sometimes show very high sequence identity. This may complicate assignment during genome assembly. One such example is in Xq28, where the arrangement of 2 recently duplicated segments varies between genome assembly versions. The duplicated segments comprise highly similar genes, including MAGEA3 and MAGEA6, which display specific expression in testicular germline cells, and also become aberrantly activated in a variety of tumors. Recently, a new gene was identified, CT-GABRA3, the transcription of which initiates inside the segmental duplication but extends far outside. According to the latest genome annotation, CT- GABRA3 starts near MAGEA3, with which it shares a bidirectional promoter. In an earlier annotation, however, the duplicated segment was positioned in the opposite orientation, and CT-GABRA3 was instead coupled with MAGEA6. To resolve this discrepancy, and based on the contention that genes connected by a bidirectional promoter are almost always co-expressed, we decided to compare the expression profiles of CT-GABRA3, MAGEA3, and MAGEA6. We found that in tumor tissues and cell lines of different origins, the expression of CT-GABRA3 was better correlated with that of MAGEA6. Moreover, in a cellular model of experimental induction with a DNA demethylation agent, activation CT-GABRA3 was associated with that of MAGEA6, but not with that of MAGEA3. Together these results support a connection between CT-GABRA3 and MAGEA6 and illustrate how promoter-sharing genes can be exploited to resolve genome assembly uncertainties.
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Riente, Fabrizio, Umberto Garlando, Giovanna Turvani, Marco Vacca, Massimo Ruo Roch, and Mariagrazia Graziano. "Corrections to “MagCAD: A Tool for the Design of 3-D Magnetic Circuits” [2017 65-73]." IEEE Journal on Exploratory Solid-State Computational Devices and Circuits 3 (December 2017): 111. http://dx.doi.org/10.1109/jxcdc.2018.2794158.

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Seager, RJ, Erik Van Roey, Shuang Gao, Jonathan Andreas, Vincent Giamo, Blake Burgher, Felicia Lenzo, et al. "64 Cancer testis antigen co-expression landscape in solid tumors." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (November 2020): A69. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0064.

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BackgroundCancer testis antigens (CTAs) are tumor antigens that have a highly tissue-restricted expression but are often expressed in diverse malignancies. With their highly immunogenic expression limited to tumor cells, CTAs have become a prime target for cancer vaccinations and T-cell-based therapy with chimeric T-cell receptors. In this study, we investigated the landscape of 17 CTA (NY-ESO-1, LAGE-1A, and 15 other CTAs) in the context of the tumor immune microenvironment of real-world clinical tumors spanning multiple histologies.MethodsRNA-seq was performed on 5450 FFPE tumors, and the expression of each of the 17 CTAs were classified as Positive (nRPM≥20) or Negative (nRPM<20). Pearson correlation analysis was conducted on the nRPM values for each CTA to determine co-expression relationships between any of the 17 CTAs. In order to visualize patterns in the CTA expression landscape, heatmap analysis was performed, using hierarchical clustering with Pearson’s correlation as a distance measure to reveal patterns in CTA status across all samples and CTAs.Results5450 tumor samples analyzed in this study spanned 39 histologic types of tumor and were predominantly composed of lung cancer (40.4%) followed by colorectal cancer (10.6%) and breast cancer (8.6%). Positive CTA prevalence ranged from 2.4% (GAGE13) to 31.5% (XAGE1B). A high degree of significant correlation between the expression of all CTAs was observed, with only GAGE10, XAGE1B, MLANA, MAGEA4, GAGE13, and SSX2 having a no significant correlation with at least one other CTA. Three key groups of co-expressed CTAs were observed: 1) NY-ESO-1, LAGE-1A, MAGEA12, MAGEA3, MAGEA1, MAGEA10, and MAGEA4 (0.36≤R≤0.82); 2) GAGE12J, GAGE2, GAGE1, GAGE13 (0.58≤R≤0.72); 3) SSX2, BAGE, MAGEC2 (0.4≤R≤0.58). The three remaining CTAs (GAGE10, XAGE1B, and MLANA) had little or no (R<0.22) correlation with any other CTA or each other. Clustering CTAs across all samples revealed three CTA expression clusters: 1) samples that express a collection of multiple CTAs; 2) samples that express mostly XAGE1B, over-represented by lung cancer (p=1.51e-296); 3) samples that express mostly GAGE10, over-represented by neuroendocrine tumors (p=1.64e-05).ConclusionsAcross multiple cancer subtypes, the expression of a CTA occurs in the context of other CTAs, and specific groups of CTAs are likely to co-express, forming expression patterns characteristic to tumor subgroups. These findings provide a scientific base for selecting appropriate CTAs and designing multiplex vaccination in immunotherapies of a variety of tumors. Further studies are needed to understand the relationship of these CTAs with traditional and emerging immune-oncology biomarkers.
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Hurtado López, Ana M., Tzu Hua Chen-Liang, Joaquín Panadero, Eduardo José Salido, Victor Beltrán, Begoña Muiña, Noelia Navarro-Villamor, et al. "TFDP3and DDX53 are Highly Re-Expressed after One Cycle of Azacitidine in Myelodysplastic Syndrome Patients Achieving Complete Response: A Cancer Testis Antigen RNA-Seq Screening." Blood 132, Supplement 1 (November 29, 2018): 4340. http://dx.doi.org/10.1182/blood-2018-99-117851.

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Abstract Background and Aim: Azacitidine have shown clinical activity in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), particularly at low, non-cytotoxic doses favoring hypomethylation over cytotoxicity. Cancer/testis antigens (CTAs, encoding for immunogenic proteins which are normally expressed in the testicles and trophoblastic cells of the ovary, have been shown to undergo derepression after the use of demethylating agents in cancer cell line models. We took advantage of the unique model of Aza-treated high risk MDS to in vivocharacterize candidates for immunotherapy following hypometilating therapy. Methods:Targeted RNA-Seq (tRNA-Seq) designed to capture 214 CTA genes was performed in 19 MDS or CMML patients at day 0 and at day +28 after first AZA cycle. In 10 patients the analysis was extended to third and/or four cycles. Sequencing, coverage, mapping and alignment was performed using the Ion Torrent Browser Suite. We used LIMMA package or empirical analysis of digital gene expression data in R (edgeR) to identify differential expressed genes. A homogeneous treatment schedule with AZA (75 mg/m2/day x 7 days) was received by each patient.The response criteria were from IWG 2006, including a bone marrow and cytogenetic reevaluation after 6 cycles. The main candidates selected from de tRNA-seq experiment were characterized at protein level in cell lysate and/or plasma by Western Blot. Primary antibodies used from Thermo Fisher were: ADAM29, DDX53, PRAME, B-TUBULINA, FAM46D, B-ACT, TMPRSS12, MAGEB4, GAPDH, MAGEA1, MAGEA2, TSPY2, Cxorf48, DNAJB8, NY-ES0-1, CT83/Cxorf61 and TFDP3 from Santa Cruz Biotechnology. We used either cell lysate or plasma to study the protein levels in non-reducing SDS-PAGE at different acrylamide concentration depending on the protein size. ImageJ was used to quantify protein levels. Results:The median age of the cohort was 69 (range 48-81 years). The cohort consisted of 16 MDS and 3 CMML patients. MDS Patients were stratified based on IPSS as low or intermediate-1 (n=14) and intermediate-2 or high (n=2) risk groups and CMML patients based on a CPSS of intermediate-2 (n=3). Five patients were classified as complete responders achieving a complete cytogenetic and/or marrow remission (CR). Regarding the tRNA-Seq, on average, we achieved 3.888.308 mapped reads per sample (p25-p75, 1.2x106 - 5.9x106) which represents a sufficient depth for digital gene expression profiling of 214 genes. CTAs re-expressed significantly after one AZA cycle in complete responders were TFDP3 (FC=6,4), ZNF645 (FC=2), MAGEB4 (FC=3,1), MAGEA5 (FC=2), DDX53 (FC=2), VENTPX1 (FC=5,5), TSPY2(FC=3,4) and TSYP3 (FC=3,5). Other potential candidates with significantly re-expression in any responders vs. non responder were:SLCO6A1, ADAM29, DDX53, PRAME, FAM46D, TMPRSS12, MAGEA1, MAGEA2, Cxorf48, DANJB8, NYESO-1 and CT83. In the western-blot experiments, protein expression, longitudinally measured in peripheral blood lysate and/or plasma showed a parallel dynamic to gene expression in the case of TFDP3and DDX53. Conclusions:In this study, targeted RNA-seq is shown as effective and accurate tool to detect weakly expressed transcripts as CTAs. In this work, TFDP3 and DDX53, validated at proteomic level, emerge as most promising candidates for immunotherapy in combination with hypomethylating agents in MDS patients. Disclosures No relevant conflicts of interest to declare.
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Dissertations / Theses on the topic "MagCAD"

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Cardoso, Patrícia Schlithler da Fonseca. "Voces magicae: o poder das palavras nos Papiros Gregos Mágicos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/8/8143/tde-25102016-134116/.

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Os Papiros Gregos Mágicos são uma coletânea de textos sobre magia do Egito Greco-Romano. Seus feitiços mostram uma mistura de várias tradições, em especial a egípcia e a grega. Uma característica dessa coletânea que se destaca é a presença das chamadas voces magicae, palavras mágicas de aspecto misterioso e sem sentido lexical aparente. Esta dissertação se concentra em analisar as voces magicae em seu contexto textual, a fim de compreender melhor como esse elemento ocorre nos encantamentos. Para isso, foi estabelecido um banco de dados com as voces magicae de cada feitiço e as mesmas foram analisadas levando em conta os termos que eram adjacentes à elas. Os tipos de contexto nos quais as palavras mágicas figuram foram discutidos a partir de exemplos retirados do corpus. Com base nessa análise, foi possível levantar algumas hipóteses sobre a natureza das palavras mágicas e o tipo de função que exercem nos feitiços.
The Greek Magical Papyri are a collection of magical texts from Graeco-Roman Egypt. Its contents display a mixture of different traditions, mainly Egyptian and Greek. A noticeable feature in these texts is the so-called voces magicae, mysterious looking words with no apparent lexical meaning. This dissertation focuses on analyzing the voces magicae in their textual context in order to better comprehend how this feature appears on incantations. A database was established with vox magica taken from the spells. The voces magicae were analyzed according to the words next to them. The different contexts in which voces magicae were found were discussed with examples from our corpus. Based on this analysis, it was possible to raise a few hypotheses on the nature of magical words and what kind of function they have on spells.
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Snyder, Darin C. "Processes and Time Scales of Differentiation in Silicic Magma Chambers: Chemical and Isotopic Investigations." Connect to this document online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=miami1113844626.

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Thesis (Ph. D.)--Miami University, Dept. of Geology, 2005.
Title from second page of PDF document. Document formatted into pages; contains [3], viii, 216 p. : ill. Includes bibliographical references (p. 151-159).
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Patrón, Panana Paola Alexandra. "Construyendo y deconstruyendo a las Magical Girls: un estudio sobre la representación de roles de género y orientación sexual en los animes Magical Girl “CardCaptor Sakura” (1998) y “Puella Magi Madoka Magica” (2011)." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2020. http://hdl.handle.net/20.500.12404/17411.

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La presente investigación pretende analizar la representación de roles de género y orientación sexual de los personajes principales y secundarios en los animes Magical Girl. Para esto, se seleccionó dos animes, CardCaptor Sakura (1998) y Puella Magi Madoka Magica (2011), para poder realizar una comparación en varios puntos. Se utilizó una metodología mixta que combina lo cuantitativo con lo cualitativo. Primero, se analizó la representación de roles de género, utilizando matrices para evaluar la presencia de atributos femeninos en los personajes principales de ambos animes. A continuación, se tomó las características básicas del género Magical Girl y se realizó una comparación, que evaluó la manera en que estas características son presentadas en ambos animes. Luego, se analizó la representación de orientaciones sexuales, centrando la investigación en la representación de personajes queer, contabilizando la presencia de instancias que muestren identidades no heteronormativas y la manera cómo son presentadas explícitamente en el texto. Como complemento, se contabilizó la cantidad de personajes queer presentes en los animes. Los hallazgos obtenidos se complementaron con el análisis de una selección de escenas en ambos animes, para profundizar en las acciones y relaciones de los personajes. Como conclusión encontramos que la representación de género sigue siendo diversa pero que el intento de deconstruir el género Magical Girl ocasiona que se castigue la feminidad que caracterizaba a estos animes. A la vez, la representación de orientaciones sexuales ha dejado de ser explícita y los animes han pasado a mostrar subtextos, sin llegar a evidenciar la representación en el texto mismo
Tesis
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Liu, Lei. "The link between convection and crystallization in a sub-axial magma chamber and heat output in a seafloor hydrothermal system." Thesis, Available online, Georgia Institute of Technology, 2007, 2007. http://etd.gatech.edu/theses/available/etd-07072007-142506/.

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Conrod, Heidi Jill. "Magical Thinking." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35202.

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In Magical Thinking, Heidi Conrod explores through the act of painting, the depiction of mental states through the cautious release and withholding of visual, conceptual, and autobiographical cues. Reflecting on the nature of memory and time and the fluid ways in which these seemingly immaterial phenomena interact, the paintings represent multiple visions within one viewing experience; commenting not only on the surface of things, but also on what may lie hidden beneath. The works are best understood through introspection rather than a forced rationale. These paintings are intended to read like a stream, or perhaps a pool of consciousness, where the unconscious is expressed through swirls of imagery with surrealist undertones alluding to the seemingly contradictory conditions of dream and reality. Here fact, fiction, memory and imagination, are intertwined in a non-linear style through a multitude of painterly applications.
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Loar, Patrice. "Magical Process." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/honors_theses/40.

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The use of supernatural beings in four of Shakespeare’s plays – A Midsummer Night’s Dream, Romeo and Juliet, Macbeth, and The Tempest – is examined in order to show the change in Shakespeare’s thinking about magic, and how the mortal and supernatural can co-exist. The shift from properly controlled benevolent female power, to out-of-control malevolent female power, to the eradication of female power and triumph of the male magus is examined; the ideal co-existence of the human and supernatural worlds is assessed.
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Santos, Georgina Silva dos. "O sabá do sertão: feiticeiras, demônios e jesuítas no Piauí colonial (1750-58)." reponame:Repositório Institucional da UFF, 2013. https://appdesenv.uff.br/riuff/handle/1/185.

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Submitted by Maria Dulce (mdulce@ndc.uff.br) on 2013-12-09T18:13:40Z No. of bitstreams: 2 Silva, Carolina-Dissert-Historia-2013.pdf: 1393729 bytes, checksum: 1159b41f8f014cee019e1d5f035ff5ae (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)
Made available in DSpace on 2013-12-09T18:13:40Z (GMT). No. of bitstreams: 2 Silva, Carolina-Dissert-Historia-2013.pdf: 1393729 bytes, checksum: 1159b41f8f014cee019e1d5f035ff5ae (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2013
Esta dissertação tem como eixo principal os depoimentos de duas escravas mestiças, Joana e Custódia de Abreu, que assumiram participar de encontros noturnos firmados por pactos diabólicos no Piauí colonial. O documento foi escrito e enviado ao Tribunal do Santo Ofício de Lisboa pelo jesuíta Manuel da Silva e possui descrições muito semelhantes com os elementos que definem o complexo sabático europeu. O texto foi resultado da confluência de diversas crenças mágico-religiosas, a descrição dos encontros noturnos com o diabo se aproximou ora da magia popular, ora dos calundus coloniais e ora do sabá europeu. As intenções do padre ao enviar as confissões para a Inquisição parecem vir da vontade de denunciar o estado de “abandono religioso” dos sertões e de destacar a importância da Ordem do qual fazia parte. As fontes também funcionaram como indícios que levaram a compreensão de um cenário mais amplo e multifacetado, no qual foi possível investigar: o amplo uso de práticas mágicas no reino e na América Portuguesa; o papel da Companhia de Jesus no processo de colonização e catequização dos ameríndios, e as adaptações que a Instituição sofreu no Brasil; a ocupação dos sertões através da “Guerra dos Bárbaros”; e a formação cultural e religiosa do Piauí no século XVIII.
This work has a main axis testimony from two slave crossbred, and Custodian of Jeanne Abreu, who took part in nightly meetings diabo9lical pacts signed by the colonial Piaui. The document whas written and sent to the Court of the Inquisition of Lisbon by the Jesuit Manuel da Silva and has very similar descriptions with the elements that define the complex European sabbatical. The text was the result of the confluence of the several magical-religious beliefs, the description of the nocturnal meetings with the devil approached either of folk magic, sometimes calunduns of colonial and now European Sabbath. The intentions of priest to send the confessions to the Inquisition seem to come from the desire to terminate the state of the “religious abandonment” of the interiors and emphasize the importance of which was part of the Order. The sources also functioned as evidence that led to understanding of a more broad and multifaceted, in which was possible to investigate: the widespread use of magical practices in the kingdom and in Portuguese America, the role of the Society of Jesus in the process of colonization and catechizing the Amerindians, and the adjustments that the institution has suffered in Brazil, the occupation of the hinterland through the “War of the Barbarians” and the cultural and religious formation of Piaui in the eighteenth century.
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Sturesson, Johan, and Edvin Henningsson. "Tillförlitlighet kring beräkningsmetoder av luftdistributionssystem i Revit MagiCAD." Thesis, Linnéuniversitetet, Institutionen för byggteknik (BY), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-87515.

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Utvecklingen och etablerandet av BIM vid projektering av ventilationssystem har förenklat arbetsprocessen för branschens projektörer. BIM har med 3D-objekt förändrat projekteringen i byggbranschen och har successivt etablerat sig och används av projektörer runt om i hela världen. 3D-modeller ger möjlighet att tidigt utföra beräkningar på blivande system och se om kraven som ställs blir uppfyllda.  Det vanligaste använda BIM-verktyget för projektering av VVS-system är MagiCAD, som är en tilläggsapplikation för både Revit och AutoCAD. MagiCAD i Revit-miljö är relativt nytt i byggbranschen som börjar etablera sig och används idag av VVS-projektörer i över 75 länder runt om i världen. Rapporten avser att testa tillförlitligheten för beräkningar i luftbehandlingssystem utförda i Revit MagiCAD. Resultat från traditionella tillvägagångssätt vid liknande beräkningar jämförs mot de resultat som genereras i Revit MagiCAD. Tillförlitligheten ansågs vara hög då resultat från både handberäkningsmetoder och MagiCAD var likvärdiga. Revit MagiCAD kan därför anses vara ett tillförlitligt beräkningsverktyg för distributionssystem i VVS-installationer.
The progress and establishment of BIM for designing ventilation systems have simplified the work process for the industry's projectors. With 3D objects, BIM has revolutionized the design in the construction industry and has gradually established itself and is used by HVAC and MEP designers around the world. 3D models provide the opportunity to perform calculations on projected systems early and see if the requirements are met. The main BIM tool for designing air distribution systems is MagiCAD, which is an application in both Revit and AutoCAD. Revit MagiCAD is relatively new in the construction industry but is also starting to establish itself and is today used by HVAC and MEP engineers in over 75 countries around the world. The report aims to test the reliability of calculations in air distribution systems performed in Revit MagiCAD. Results from traditional approaches in similar calculations are compared against the results generated in Revit MagiCAD. Reliability was considered high when results from both hand calculation methods and MagiCAD were equivalent. Revit MagiCAD can therefore be confirmed as a reliable calculation tool for distribution systems in plumbing installations.
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Pressi, Leonardo Frederico. "Evolução magmática do plúton Piracaia (SP): parâmetros físico-químicos e evidências de mistura entre magmas monzodioríticos e sieníticos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/44/44143/tde-11032013-104316/.

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O presente trabalho investiga processos de interação e mistura parcial de magmas monzodioríticos e sieníticos s.l. no Plúton Piracaia,(~ 580 Ma), que pertence à Província Granítica Itu, de caráter pós-orogênico. O Plúton Piracaia é uma intrusão alongada com cerca de 30 km2, formada por cinco unidades: Monzodioritos grossos (Mdr); Monzodioritos finos (Mdf); Monzonitos heterogêneos (Mh); Sienitos (Sie); quartzo sienitos e quartzo monzonitos (Qsie). Como base para a caracterização dos processos de interação de magmas, foram estimados os parâmetros físico-químicos dos magmas primários e híbridos identificados no plúton. As temperaturas liquidus foram estimadas a partir da saturação em apatita, e são da ordem de 950-1050°C para os magmas mais primitivos (Mdf) e 850-900°C para os mais diferenciados (quartzo sienitos). As temperaturas solidus, estimadas através das relações de equilíbrio entre hornblenda e plagioclásio, são da ordem de 750°C para Mdf, e 650-700°C para Sienitos e quartzo sienitos (Qsie). A profundidade de alojamento do plúton é estimada em ~13-15 km com base nas pressões estimadas para Mdf com base no conteúdo de Al na hornblenda. A concentração de H2O nos magmas foi estimada com base no teor de An do plagioclásio, conhecida a temperatura de cristalização, que indicou valores da ordem de 2,5-3,3% para Mdf, alcançando até 5% nos quartzo sienitos. Estimativas da fO2 a partir da composição química de cristais de magnetita e ilmenita não puderam ser obtidas, devido a reequilíbrio pós-magmático. Deste modo, foram obtidos valores aproximados com base no conteúdo de ulvoespinélio de cristais de magnetita reconstituídos e no conteúdo da molécula ilmenita dos cristais de ilmenita; em paralelo, foram também utilizadas as razões Fe/(Fe/Mg) de anfibólio e biotita. Os resultados revelaram um importante contraste entre as unidades Mdf e Mdr, caracteristicamente oxidadas, com valores próximos aos do buffer NNO, e as demais unidades, onde quartzo sienitos (Qsie) e especialmente Sie mostram-se mais reduzidas. Os baixos valores de susceptibilidade magnética medidos em campo para as unidade Sie e Mh, que a ela se associa, devem ser reflexos do seu caráter mais reduzido. Ao longo da história de construção da câmara, que foi alimentada intermitentemente por magmas de composição variada, dois eventos principais de interação de magmas foram identificados, com características distintas: (i) interação de magmas monzodioríticos (Mdf) e sieníticos (Sie), gerando a unidade de Monzonitos heterogêneos (Mh), na qual a intensa interdigitação de porções monzodioríticas e sieníticas sugere uma forte atuação mecânica, favorecendo a hipótese de que os magmas tenham se misturado previamente ao alojamento final; e (ii) interação de magmas monzodioríticos (Mdf) e quartzo sieníticos (Qsie), gerando diversas estruturas de coexistência, mistura localizada e possivelmente as rochas quartzo monzoníticas da unidade ( Qsie); neste caso, a interação entre os magmas possivelmente ocorreu na câmara magmática, como sugerido pelas características das estruturas indicativas de coexistência (enclaves e pillows de composição monzodiorítica).
The present study investigates the interaction and partial mixing of monzodiorite and syenite s.l. magmas in the Piracaia Pluton (~580 My), which is part of the post-orogenic Itu Granite Province. The Piracaia Pluton is an elongated intrusion with approximately 30 km², composed by five units: Coarse-grained monzodiorites (Mdr); Fine-grained monzodiorites (Mdf); Heterogeneous monzonites (Mh); Syenites (Sie); quartz syenites and quartz monzonites (Qsie). The physico-chemical crystallization parameters of the primary and hybrid magmas identified in the pluton were determined as references for the characterization of the magma interaction processes. The liquidus temperatures were estimated based on apatite saturation, and are in the range of 950-1050º C for the most primitive magmas (Mdf) and 850-900º C for the more differentiated ones (quartz syenites). The solidus temperatures, estimated on the basis of the equilibrium between hornblende and plagioclase, are about 750º C for Mdf, and 650-700º C for and quartz syenites (Qsie). The depth of emplacement is estimated at 13-15 km, as indicated by pressure estimates for Mdf, based on the Al-in-hornblende content. The H2O concentration of the magmas was estimated based on the An content of plagioclase, with results are in the range of 2.5-3.3% for Mdf, reaching up to 5% in quartz syenites. fO2 estimates based on the composition of coexisting magnetite and ilmenite could not be performed, due to post-magmatic re-equilibration. However, approximate values were obtained based on the ulvospinel content of reconstructed titanomagnetite crystals, and on the content of ilmenite molecule in ilmenite crystals; in parallel, the Fe/(Fe/Mg) ratios of amphibole and biotite were also used. The results show an important difference between the Mdf and Mdr units, which are distinctively oxidized, with values near the NNO buffer, and the other units which have lower ?O2, the quartz syenites and especially the syenites being the more reduced units. The lower magnetic susceptibility values measured in the field for the Sie and Mh units must reflect their more reduced nature. During the construction of the magma chamber, which was intermittently recharged by magmas of varied composition, two main events of magma interaction with distinct characteristics were identified: (i) the interaction of monzodiorites (Mdf) and syenites (Sie), generating the Heterogeneous monzonite unit, in which the interfingering of monzodiorite and syenite portions suggest a strong mechanical interaction, favoring the hypothesis that the magmas were already mixing previously to the final emplacement; (ii) interaction of monzodiorite (Mdf) and quartz syenite (Qsie), generating diverse mingling structures, local hybridization and possibly the quartz monzonite rocks of the unit Qsie; in this case, the magma interaction must have occurred at the magma chamber, as suggested by the type of structures indicative of coexistence (enclaves and monzodiorite pillows).
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Perfect, James. "Modern magic and magical practice : understanding the modern magical paradigm." Thesis, University of Wales Trinity Saint David, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683200.

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Books on the topic "MagCAD"

1

Page, Patrick. Gran manual de trucos y magia. Barcelona: Editorial De Vecchi, 1989.

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Page, Patrick. Gran manual de trucos y magia. Barcelona: Editorial De Vecchi, 2001.

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Li-heyot magad. [Moshav Ben Shemen]: Modan, 2013.

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R, Carroll Michael, and Holloway John R, eds. Volatiles in magmas. Washington, D.C: Mineralogical Society of America, 1994.

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1931-1986, Varmā Śrīkānta, Varmā Śrīkānta 1931-1986, and Soni Rahul translator, eds. Magadh. Mumbai: Almost Island Books, 2013.

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Delta, Pēnelopē Stephanou. Magkas. 2nd ed. Athēna: Vivliopōleion tēs Hestias, 2011.

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Sėrzhėė, Zh, Zhu̇mpėrėliĭn Saruulbui︠a︡n, and T︠S︡ T︠S︡ėrėndorzh. Manzhiĭn u̇nėn magad khuulʹ. Ulaanbaatar Khot: Mongolyn U̇ndėsniĭ Muzeĭ, 2009.

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America, Mineralogical Society of, Geochemical Society, and AGU Fall Meeting (2008 : San Francisco, Calif.), eds. Minerals, inclusions and volcanic processes. Chantilly, Va: Mineralogical Society of America, 2008.

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Barker, Marjorie. Magical Hands. Saxonville, MA: Picture Book Studio, 1989.

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Brink, Carol Ryrie. Magical melons. New York: Aladdin Books, 1990.

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Book chapters on the topic "MagCAD"

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Kumar, Saurabh, R. Marimuthu, and S. Balamurugan. "Design and Analysis of 4-Bit Squarer Circuit Using Minority and Majority Logic in MagCAD." In Advances in Intelligent Systems and Computing, 409–17. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0184-5_36.

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Dalal, Anshul, Manoj Choudhary, and S. Balamurugan. "Design Framework of 4-Bit Radix-4 Booth Multiplier Using Perpendicular Nanomagnetic Logic in MagCAD." In Communications in Computer and Information Science, 387–403. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-5048-2_31.

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Perugini, Diego. "The Beginning: Mafic Magmas Invading Felsic Magma Chambers." In The Mixing of Magmas, 77–86. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-81811-1_6.

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Gibson, Marion. "Magical realism, magical romance." In Rediscovering Renaissance Witchcraft, 111–30. 1 [edition]. | New York: Routledge, 2017.: Routledge, 2017. http://dx.doi.org/10.4324/9781315147802-8.

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Soreanu, Raluca. "Magmas." In Working-through Collective Wounds, 51–82. London: Palgrave Macmillan UK, 2018. http://dx.doi.org/10.1057/978-1-137-58523-3_3.

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Levesque, Roger J. R. "Magical Thinking." In Encyclopedia of Adolescence, 1635–37. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-1695-2_443.

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Roch, Eckhard. "Laterna Magica." In Psychodrama, 73–123. Stuttgart: J.B. Metzler, 1995. http://dx.doi.org/10.1007/978-3-476-03571-4_5.

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Hoyer, Gert, and Uta Hoyer. "Ungarisch – Magyar." In Ärztlicher Dolmetscher, 113–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-48739-6_8.

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Smith, Warren S. "Magical Thinking." In Religion and Apuleius' Golden Ass, 17–42. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003258469-2.

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Jayne, Lucy. "Magical Horses." In Using Art, Play, Metaphor, and Symbol with Hard-to-Reach Young Clients, 150–63. London: Routledge, 2022. http://dx.doi.org/10.4324/9781003163015-11.

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Conference papers on the topic "MagCAD"

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Garlando, U., F. Riente, G. A. Cirillo, M. Graziano, and M. Zamboni. "Design and Characterization of Circuit based on Emerging Technology: the MagCAD Approach." In 2018 IEEE 18th International Conference on Nanotechnology (IEEE-NANO). IEEE, 2018. http://dx.doi.org/10.1109/nano.2018.8626232.

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Garlando, Umberto, Fabrizio Riente, Deborah Vergallo, Mariagrazia Graziano, and Maurizio Zamboni. "ToPoliNano & MagCAD: A Complete Framework for Design and Simulation of Digital Circuits Based on Emerging Technologies." In 2018 15th International Conference on Synthesis, Modeling, Analysis and Simulation Methods and Applications to Circuit Design (SMACD). IEEE, 2018. http://dx.doi.org/10.1109/smacd.2018.8434919.

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Habash, Nizar, and Owen Rambow. "MAGEAD." In the 21st International Conference. Morristown, NJ, USA: Association for Computational Linguistics, 2006. http://dx.doi.org/10.3115/1220175.1220261.

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Xu, Ding, Ali Momeni, and Eric Brockmeyer. "MagPad." In the 28th Annual ACM Symposium. New York, New York, USA: ACM Press, 2015. http://dx.doi.org/10.1145/2815585.2815740.

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Tóth, Gábor, and Mónika Merczi. "Ács-Öbölkúti-dűlő lelőhely római kori sírjainak embertani eredményei." In Hadak útján XXIV. : A népvándorláskor fiatal kutatóinak XXIV. konferenciája. PPKE BTK Régészeti Tanszék, MTA BTK Magyar Őstörténeti Témacsoport, 2015. http://dx.doi.org/10.55722/arpad.kiad.2015.3.1_05.

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2008 novembere és 2009 áprilisa között a Kulturális Örökségvédelmi Szakszolgálat megbízásából a Scott és Csoma szélerőmű-park területén, az Ács-Öbölkúti-dűlő lelőhelyen Fűköh Dániel vezetésével végeztek régészeti feltárást. A helyszínen egy késő római (3–4. századi) telep és a hozzá tartozó temető részletét sikerült feltárni. A feltárt 38 római kori sír a Magyar Nemzeti Múzeum leltározott gyűjteményébe tartozik. A nemi eloszlás alapján 18 esetben férfi, 13 esetben nő nyugodott a sírban. Az alacsony sírszám és a mennyiségében és minőségében nem reprezentatív temetőrészlet ellenére, a szükséges korrekciók után, kísérlet történt a halandósági viszonyok meghatározására. Mindenképpen figyelemre méltó a rövidfejűség magas aránya. Ha ezt a népességet is a római korban általános hosszúfejűség jellemezné, akkor azoknak a vizsgálható koponyák között is meg kellene jelenni. Ez az embertani megfigyelés mindenesetre szükségessé teszi a régészeti leletanyag körültekintő és alapos vizsgálatát.
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Ungváry, Rudolf. "A földrajzi személyi hungarikum feldolgozásának problematikája." In Networkshop. HUNGARNET Egyesület, 2021. http://dx.doi.org/10.31915/nws.2021.4.

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A magyar vagy magyar vonatkozású szerzőknek, csakúgy, mint külföldi társaiknak, van két alapvető földrajzi meghatározottsága: a születési és a halálozási helyük. Ezeknek azért van jelentőségük, mert arról tájékoztatnak, hogy honnan származik a szerző, illetve arról, hogy hol halt meg. A magyar és magyar vonatkozású szerzők esetében tárgyalt földrajzi nevek mind magyar vonatkozásúak, ezért hungarikumnak tekinthetőek. Így bevezethetjük a földrajzi személyi hungarikum fogalmát. Ennek minősül minden olyan földrajzi hely, amely magyar vonatkozású személyek születési és halálozási helye, külföldi állomáshelye, hungarikum kiadási helye.
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Liao, Qianru, Yongzhi Huang, Yandao Huang, Yuheng Zhong, Huitong Jin, and Kaishun Wu. "MagEar." In MobiSys '22: The 20th Annual International Conference on Mobile Systems, Applications and Services. New York, NY, USA: ACM, 2022. http://dx.doi.org/10.1145/3498361.3538921.

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Bianchi, Andrea, and Ian Oakley. "MagnID." In TEI '15: Ninth International Conference on Tangible, Embedded, and Embodied Interaction. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2677199.2680582.

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Csehy, Zoltán. "„Róka maga farkát szokta csak dicsérni” : Beniczky Péter a magyar és a szlovák irodalomban." In Zrínyi Miklós és a magyarországi barokk költészet : Tudományos konferencia. Eszterházy Károly Egyetem Líceum Kiadó, 2021. http://dx.doi.org/10.17048/zrinyimiklos.2021.313.

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Hunyadi, Attila. "A kémiai tér bővítése." In XV. Magyar Gyógynövény Konferencia. Szeged: Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztálya, 2018. http://dx.doi.org/10.14232/mgyk.2018.e1.

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Reports on the topic "MagCAD"

1

Neyedley, K., J. J. Hanley, Z. Zajacz, and M. Fayek. Accessory mineral thermobarometry, trace element chemistry, and stable O isotope systematics, Mooshla Intrusive Complex (MIC), Doyon-Bousquet-LaRonde mining camp, Abitibi greenstone belt, Québec. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/328986.

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The Mooshla Intrusive Complex (MIC) is an Archean polyphase magmatic body located in the Doyon-Bousquet-LaRonde (DBL) mining camp of the Abitibi greenstone belt, Québec, that is spatially associated with numerous gold (Au)-rich VMS, epizonal 'intrusion-related' Au-Cu vein systems, and shear zone-hosted (orogenic?) Au deposits. To elucidate the P-T conditions of crystallization, and oxidation state of the MIC magmas, accessory minerals (zircon, rutile, titanite) have been characterized using a variety of analytical techniques (e.g., trace element thermobarometry). The resulting trace element and oxythermobarometric database for accessory minerals in the MIC represents the first examination of such parameters in an Archean magmatic complex in a world-class mineralized district. Mineral thermobarometry yields P-T constraints on accessory mineral crystallization consistent with the expected conditions of tonalite-trondhjemite-granite (TTG) magma genesis, well above peak metamorphic conditions in the DBL camp. Together with textural observations, and mineral trace element data, the P-T estimates reassert that the studied minerals are of magmatic origin and not a product of metamorphism. Oxygen fugacity constraints indicate that while the magmas are relatively oxidizing (as indicated by the presence of magmatic epidote, titanite, and anhydrite), zircon trace element systematics indicate that the magmas were not as oxidized as arc magmas in younger (post-Archean) porphyry environments. The data presented provides first constraints on the depth and other conditions of melt generation and crystallization of the MIC. The P-T estimates and qualitative fO2 constraints have significant implications for the overall model for formation (crystallization, emplacement) of the MIC and potentially related mineral deposits.
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2

Alvarez, Diana, and Mikyoung Whang. A Magical Labyrinth. Ames: Iowa State University, Digital Repository, November 2015. http://dx.doi.org/10.31274/itaa_proceedings-180814-1181.

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3

Daniel M. Ibrahim, Daniel M. Ibrahim. The LilBubome - Sequencing LilBub's Magical Genome. Experiment, June 2014. http://dx.doi.org/10.18258/2682.

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4

Csiffáry, Gabriella. Bárczy István, a legsportosabb főpolgármester... : Ismeretlen ismerős 3. Budapest Főváros Levéltára, 2021. http://dx.doi.org/10.56045/blm.2021.12.

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Budapest egykori főpolgármestere (1918-1919), a rövid ideig igazságügy-miniszteri tisztséget is betöltő Bárczy István fiatal korában sokoldalú és sikeres sportolóként kezdte pályafutását. Sport iránti szeretete mindvégig megmaradt. Atlétikában, vívásban és birkózásban és más sportágban is jeleskedett. A Magyar Atlétikai Szövetség (MASz) elnökeként, amely tisztséget 1907 és 1918 között töltötte be, sokat tett a magyar sport érdekében.
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5

Sarusi Kiss, Béla. Lengyel menekült közjegyzők Magyarországon 1939–1944. Budapest Főváros Levéltára, 2020. http://dx.doi.org/10.56045/blm.2020.6.

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A második világháború kitörése után Magyarország a német követelésnek helyt nem adva befogadta és széleskörű társadalmi szolidaritás mellett támogatta a lengyel menekülteket. A Budapesti Közjegyzői Kamara irataiban lengyel közjegyzők segélykérelmei, valamint magyar, német és lengyel nyelvű levelek segítségével ismerhető meg a magyar–lengyel kapcsolatok egy eddig kevéssé ismert mozzanata. A levelek további információkkal szolgálnak a lengyel menekülteket befogadó magyarországi táborokra vonatkozóan is.
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6

Koltai, Gábor. Krassó György és a Magyar Október Szabadsajtó Tájékoztatószolgálat. Budapest Főváros Levéltára, 2021. http://dx.doi.org/10.56045/blm.2021.3.

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A cikk a Krassó által működtetett Magyar Október Szabadsajtó Tájékoztatószolgálat iratainak és hangkazettáinak archívumát és annak feldolgozására létrejött projekt eredményeit ismerteti. Az 1986–89 között készült magyar és angol nyelvű londoni hírlevelek naprakész tudósítást adnak a hazai ellenzék rendszerváltás felé vezető küzdelmeiről, az ellenzéki megmozdulásokról és az emigráns szervezetekről. Alapjuk emigránsok és hazai ellenzéki vezetők által folytatott rögzített telefonbeszélgetések voltak.
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7

Yeaw, Christopher T. MagRad: A code to optimize the operation of superconducting magnets in a radiation environment. Office of Scientific and Technical Information (OSTI), January 1995. http://dx.doi.org/10.2172/531085.

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8

Grondahl, C., A. Tsay, and Z. Zajacz. Controls on the ore fertility of arc magmas. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 2019. http://dx.doi.org/10.4095/315007.

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9

Fehér, Csaba. 95 éve szól a rádió... Budapest Főváros Levéltára, 2020. http://dx.doi.org/10.56045/blm.2020.21.

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1925-ben hangzott el a Magyar Telefonhírmondó és a Magyar Rádió első közös adása. Előzményeinek, Puskás Tivadar találmányának, az 1893-ban indult telefonhírmondó működésének bemutatásával indít a cikk, majd végigkíséri a kísérleteket, a technikai és jogi feltételeket és hátteret, kapcsolatát az MTI-hez, az első, immár a vezeték nélküli hálózat segítségével felhangzó műsor hátterét és a résztvevőket. A rádió népszerűségét az előfizetők számának gyors emelkedése is alátámasztja.
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10

D. Krier. Magma Dynamics at Yucca Mountain, Nevada. Office of Scientific and Technical Information (OSTI), August 2005. http://dx.doi.org/10.2172/859089.

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