Journal articles on the topic 'Mae Hong Son'

We applied remote sensing and aerial photographic techniques to a study of the Mae Hong Son Fault (MHSF), located in the Mae Hong Son region, northern Thailand. Several fault lines are recognized in the region, trending mainly NE–SW, NW–SE, and N–S. The main morphotectonic landforms associated with the MHSF are fault scarps, offset streams, linear valleys, triangular facets, offset ridge crests, hot springs, and linear mountain fronts. A trench, a quarry, and a road cut in Caenozoic strata were used to analyze fault geometries in the area. We identified eight paleoearthquake events from trenching, quarry, and road-cut data, and from optically stimulated luminescence (OSL) and thermoluminescence (TL) dating. The OSL and TL ages of the events are: (1) 78,000 yr BP; (2) 68,000 yr BP; (3) 58,000 yr BP; (4) 48,000 yr BP; (5) 38,000 yr BP; (6) 28,000 yr BP; (7) 18,000 yr BP; and (8) 8,000 yr BP. The recurrence interval of seismic events on the MHSF appears to be ca. 10,000 years, and the slip rate was estimated as ca. 0.03–0.13 mm/yr. There is a low possibility of a large earthquake on the MHSF in the near future.

This study of the identity of Tai-Yai ethnic to promote community tourism in Mae Hong Son province is a participatory action research that aimed to find a format for building a learning center for Tai-Yai identity and to establish a network of Tai-Yai identity conservation groups that is linked to community tourism in Mae Hong Son Province. This study focused on the way of life and identity of Tai-Yai people in five districts in Mae Hong Son province include Pai, Pang Mapha, Muang, Khun Yuam, and Mae La Noi. The results of the research were as follows: the Tai-Yai communities maintain their way of life, the concept of belief in the supernatural, and Buddhism beliefs, pass on their identity to the younger generation, and transfer their identity to the general public. The Tai-Yai community of Pambok village has the potential to build a learning center for the Tai-Yai identity at the community level by linking with the Tai-Yai Education Center, Mae Hong Son province which is a “FICES” model (Sustainable Education Community Identity of Tai-Yai Faith).

Comparative morphometric and morphological studies of eggs under scanning electron microscope (SEM) were undertaken in the three strains of two karyotypic forms of Anopheles aconitus, i.e., Form B (Chiang Mai and Phet Buri strains) and Form C (Chiang Mai and Mae Hong Son strains). Morphometric examination revealed the intraspecific variation with respect to the float width [36.77 ± 2.30 µm (Form C: Chiang Mai strain) = 38.49 ± 2.78 µm (Form B: Chiang Mai strain) = 39.06 ± 2.37 µm (Form B: Phet Buri strain) > 32.40 ± 3.52 µm (Form C: Mae Hong Son strain)] and number of posterior tubercles on deck [2.40 ± 0.52 (Form B: Phet Buri strain) = 2.70 ± 0.82 (Form B: Chiang Mai strain) < 3.10 ± 0.32 (Form C: Chiang Mai strain) = 3.20 ± 0.42 (Form C: Mae Hong Son strain)], whereas the surface topography of eggs among the three strains of two karyotypic forms were morphologically similar.

Meteorological parameters play an important role in determining the prevalence of ambient particulate matter (PM) in the upper north of Thailand. Mae Hong Son is a province located in this region and which borders Myanmar. This study aimed to determine the relationships between meteorological parameters and ambient concentrations of particulate matter less than 10 µm in diameter (PM10) in Mae Hong Son. Parameters were measured at an air quality monitoring station, and consisted of PM10, carbon monoxide (CO), ozone (O3), and meteorological factors, including temperature, rainfall, pressure, wind speed, wind direction, and relative humidity (RH). Nine years (2009–2017) of pollution and climate data obtained from the Thai Pollution Control Department (PCD) were used for analysis. The results of this study indicate that PM10 is influenced by meteorological parameters; high concentration occurred during the dry season and northeastern monsoon seasons. Maximum concentrations were always observed in March. The PM10 concentrations were significantly related to CO and O3 concentrations and to RH, giving correlation coefficients of 0.73, 0.39, and −0.37, respectively (p-value < 0.001). Additionally, the hourly PM10 concentration fluctuated within each day. In general, it was found that the reporting of daily concentrations might be best suited to public announcements and presentations. Hourly concentrations are recommended for public declarations that might be useful for warning citizens and organizations about air pollution. Our findings could be used to improve the understanding of PM10 concentration patterns in Mae Hong Son and provide information to better air pollution measures and establish a warning system for the province.

A new cave-dwelling species of Cyrtodactylus Gray is described from Mae Hong Son Province in northern Thailand. The new species, C. erythrops sp. nov., is characterized by its moderate size (snout-vent length to at least 78 mm), relatively large, closely-spaced, flattened tubercles in 18–20 irregular rows at midbody, low number of ventral scales across midbody (28), absence of precloacal groove, presence of precloacal and femoral pores separated by a diastema, broad subcaudal plates, and dorsal pattern of dark spots and blotches. It is the fifth species of cave-dwelling Cyrtodactylus recorded from Thailand and its discovery adds to the mounting evidence that this genus exhibits unprecedented levels of localized endemism throughout tropical Southeast Asia.

ABSTRACT Desbutyl-benflumetol (DBB) is a novel antimalarial compound closely related to benflumetol (lumefantrine), of which it is a putative metabolite. The in vitro response of Plasmodium falciparum to DBB was studied in Mae Hong Son and Mae Sot, in northwest Thailand, in 1997 and 1998. In total, 155 fresh isolates were successfully tested using the World Health Organization standard in vitro microtest system (Mark II). The mean 50% effective concentration (EC50) and 90% effective concentration of DBB were 6.36 and 31.09 nmol/liter, respectively. The comparison of the activity of DBB and benflumetol yielded a highly significant potency ratio of 4.52, corresponding to a more than four times higher efficacy of DBB. A considerable potency difference was found between isolates from Mae Hong Son and those from Mae Sot, reflecting lesser sensitivity in the area with marked resistance to mefloquine and quinine. This observation is also supported by a highly significant activity correlation with benflumetol (P < 0.001) and to a similar degree with mefloquine (P < 0.001), reflecting a close relationship of DBB with the class II aryl amino alcohol blood schizontocides. A less distinct association was also found with artemisinin, which was significant only at the EC50 level, and there was no correlation at all with chloroquine. DBB is a promising antimalarial compound that merits further investigation in order to define its practical therapeutic potential.

Four laboratory-raised colonies of two karyotypic forms of Anopheles aconitus, i.e., Form B (Chiang Mai and Phet Buri strains) and C (Chiang Mai and Mae Hong Son strains), were experimentally infected with Plasmodium falciparum and P. vivax using an artificial membrane feeding technique and dissected eight and 12 days after feeding for oocyst and sporozoite rates, respectively. The results revealed that An. aconitus Form B and C were susceptible to P. falciparum and P. vivax, i.e., Form B (Chiang Mai and Phet Buri strains/P. falciparum and P. vivax) and Form C (Chiang Mai and Mae Hong Son strains/P. vivax). Comparative statistical analyses of the oocyst rates, average number of oocysts per infected midgut and sporozoite rates among all strains of An. aconitus Form B and C to the ingroup control vectors, An. minimus A and C, exhibited mostly no significant differences, confirming the high potential vector of the two Plasmodium species. The sporozoite-like crystals found in the median lobe of the salivary glands, which could be a misleading factor in the identification of true sporozoites in salivary glands were found in both An. aconitus Form B and C.

The aim of the present study is to provide directions on coffee tourism administration as well as to establish a coffee tourism network among the communities in Chiang Rai, Chiang Mai, Mae Hong Son, and Lampang provinces. A qualitative method is applied to the data collected from 45 attendees of a meeting on coffee tourism. They discussed several case studies and then visited Doi Chang Village in Chiang Rai to study their successful practice before exchanging views on how similar tourism management can be implemented in their own communities. With a problem tree constructed, they also identified major challenges regarding coffee tourism in Northern Thailand. The findings discusses the initiation of three projects: the community-based tourism by coffee farmers in Chiang Mai, the pilot study of a coffee tour program in Huay Hom Village, Mae Hong Son, and the project “Good Coffee in Lampang.” Also, the six coordinators of the coffee tourism network assist the communities in publicizing tourism information. With growing popularity of special interest tourism, it is surprising Thailand still lacks coffee tourism though it is blessed with several tourism advantages. Therefore, it is critical to explore whether Northern Thailand can flourish as a coffee tourism attraction.

In 2010, the second author found a possible new species of Bulbophyllum in Mae Hong Son Province, northern Thailand. Three years later, Pitak Panyachan (Queen Sirikit Botanic Garden) found the same species on a fallen tree some six km from the first locality. Living plants were collected and brought back to QSBG in Chiang Mai for further investigation. A year later, the plants flowered and proved to be a species of Bulbophyllum new to science.

The new gomphid species, Microgomphus farrelli sp. nov., is described and illustrated on the basis of male and female adult specimens and larvae collected from Chiang Mai and Mae Hong Son province, Northern Thailand. It is compared with other species of the genus. Based on the larvae this species is most closely related to Microgomphus svihleri (Asahina, 1970), comb. nov., which is the senior and valid synonym of Microgomphus thailandicus Asahina, 1981, syn. nov.

A new species of dune cricket in the family Schizodactylidae, Schizodactylus salweenensis sp. nov. is described from Salween River, Mae Hong Son Province, northwestern Thailand based on both males and females. The Schizodactylidae is recorded for the first time in Thailand. The new species is most similar to Schizodactylus tuberculatus Ander, 1938 and Schizodactylus burmanus Uvarov, 1935 in the morphology of male subgenital plate, but mainly differs in the shape of subgenital plate apex, and the spurs of hind tibiae. The type series was collected from sand dunes along the river. This cricket reaches adulthood during the rainy season.

Flash floods are water-related disasters that cause damage to properties, buildings, and infrastructures in the flow path. Flash floods often occur within a short period of time following intense rainfall in the high, mountainous area of northern Thailand. Therefore, the purpose of this study is to generate a flash flood susceptibility map using watershed morphometric parameters and hydrological approaches. In this study, the Pai River basin, located in Mae Hong Son in northern Thailand, is divided into 86 subwatersheds, and 23 morphometric parameters of the watershed are extracted from the digital elevation model (DEM). In addition, the soil conservation service curve number (SCS-CN) model is used to estimate the precipitation excess, and Snyder’s synthetic unit hydrograph method is used to estimate the time to peak and time of concentration. With respect to the rainfall dataset, in this study, we combined CHIRPS data (as satellite gridded precipitation data) with rainfall data measured within the study area for the runoff analysis. According to the analysis results, 25 out of 86 subwatersheds are classified as highly susceptible areas to flash floods. The similarities in the morphometric parameters representing watersheds in highly flash flood-susceptible areas indicate that this categorization included areas with high relief, high relief ratios, high ruggedness ratios, high stream frequencies, high texture ratios, high annual runoff, high peak discharge, low elongation ratios, and low lemniscates ratios.

Clubionidae collected in Laos and Thailand were investigated. Seven new species are described: Clubiona kai spec. nov. (male: Laos, Luang Prabang Prov.), Clubiona lala spec. nov. (female: Laos, Luang Nam Tha Prov.), Clubiona maipai spec. nov. (male: Thailand, Mae Hong Son Prov.), Clubiona kuu spec. nov. (male: Laos, Luang Prabang Prov.), Clubiona vukomi spec. nov. (male: Laos, Luang Nam Tha Prov.), Malamatidia zu spec. nov. (male: Laos, Luang Prabang Prov.) and Malamatidia christae spec. nov. (female: Laos, Luang Nam Tha Prov.). The genus Malamatidia, previously known from Sumatra, Sarawak, the Malaysian peninsular, Kalimantan, and Sulawesi is recorded from Laos (Luang Nam Tha Province) as northernmost distribution locality and is re-diagnosed. Cheiracanthium insulanum (Thorell, 1878), Cheiracanthium unicum Bosenberg and Strand, 1906, Clubiona abnormis Dankittipakul, 2008, Clubiona filicata O. Pickard-Cambridge, 1874, Clubiona melanothele Thorell, 1895 are recorded for the first time from Laos. Cheiracanthium insulanum, Clubiona abnormis, and Clubiona melanothele are additionally illustrated. A map with all records is provided.

The larva, male subimago, female imago, and eggs of V. nanensis sp. n. are described based on specimens from Mae Hong Son and Nan provinces, Thailand. The female subimago is described based on a photograph of a specimen reared to the imago stage. The species previously was distinguished only by DNA barcode data and designated as Vietnamella sp. C. Based on morphology, the larva of the new species can be distinguished with the following combination of characteristics: (i) pattern of serration on the ventral margin of the forefemur, (ii) posterolateral margins of abdominal terga with pairs of acute tubercles, especially terga VI and VII, (iii) a well-developed pair of median ridge projections on tergum X, (iv) the second segment of the maxillary palp being about 1.3× the length of the third segment, and (v) females containing eggs with prominent protuberances on the chorionic surface. A key to larvae of all known species in the genus is provided.

The purpose of this study was to compare the efficiency of native rice straw mixed bricks, prototype bricks and brick blocks that are sold in the market. The comparison looked at four aspects, as follows: (1) compression strength, (2) heat absorption, (3) weight of the brick and (4) price. In this study, the native rice straw species from the Pa Pae sub-district, Mae Sariang District, Mae Hong Son Province, Thailand, were used to replace cement, sand and stone in 200, 300, 400 and 500 g amounts. The ingredients were then mixed and put into a hand-pounded mold. When the extrusion was finished, it was removed from the mold and cured for 7, 14 or 28 days. Brick block performance was then tested. The results showed that 200 g of native rice straw mixed with cement brick had the best performance in all four aspects. The 200 g native rice straw mixed with cement brick was able to bear the weight of 1.26 kg/cm2. It had the best heat transfer and was able to reduce the temperature inside the brick-block construction by 10 degrees Celsius. Its weight per brick was 7.59 kg and the price was only 3.17 baht ($0.09 USD) per brick. In conclusion, the native rice straw mixed bricks had low thermal conductivity, are attractive for energy saving when used as wall insulation and are suitable for environmentally friendly construction.

The fruit of mulberry trees (Morus sp.), mulberries, are traditionally utilised as a nutritional food and provide health benefits as well as skin nourishment in Thailand. White mulberries (Morus alba L.) from Chiang Mai and Mae Hong Son provinces were evaluated for their antioxidant and antibacterial activities. The antioxidant activities as well as the total phenolic, flavonoid and anthocyanin content of the aqueous and ethanolic extracts were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis-(3-ethylbenzothiazolin-6-sulfonic acid) (ABTS) and ferric reducing antioxidant power (FRAP) assays. The aqueous extracts of mulberries exhibited the highest antioxidant activity, which was associated with a higher phenolic and anthocyanin content. In testing the potent antibacterial activity against Escherichia coli, Salmonella Typhi, Shigella dysenteriae, Staphylococcus aureus and Vibrio cholerae, the mulberry extracts proved to be quite efficient, especially following water extraction. Time-kill and antibacterial adhesion assays further indicated that aqueous mulberry extracts could inhibit bacterial growth and prevent adhesions of pathogenic enteric bacteria on intestinal epithelial cells. It thus appears that mulberries can potentially be consumed as a good source of antioxidants, containing antimicrobial properties against some pathogenic bacteria which cause gastrointestinal tract infections.

Prevalence of goitre was recorded in seven hill tribe villages in Mae Hong Son Province in Northern Thailand. The prevalence rate ranged from 26% to 75% with 47% of the 874 people in the sample having goitre. The prevalence and size of goitre increased with age; a 75% rate was observed in individuals under the age of 40 years. There was no association of prevalence with altitude of residence or with ethnicity. However, socio-economic level was a possible source of variation in prevalence between ethnic groups within the most accessible and best developed village (Sob Pong). No cretins were observed in these villages nor in any of the 26 nearby villages with endemic goitre. There was no evidence that cretins were hidden or subjected to passive Infanticide. In the villages that had any measures to combat iodine deficiency, the measures were inadequate and reflected a lack of knowledge in both the providers and recipients of health care. A successful programme to eradicate iodine deficiency and its accompanying diseases will require careful planning, monitoring and evaluation with the individuality of each village taken into account.

A new gekkonid lizard, Cyrtodactylus maelanoi sp. nov., from Mae Hong Son Province of the Thai Highlands is described using an integrative taxonomic analysis based on morphology, color pattern, and the mitochondrial gene NADH dehydrogenase subunit 2 (ND2) and its flanking tRNAs. Phylogenetic analyses place the new species within clade 1 of the C. sinyineensis group and as the sister species to C. inthanon with an uncorrected pairwise sequence divergence of 3.9%. Collection data gathered in the field indicate that C. maelanoi sp. nov. is a habitat generalist. Reconstruction of the ancestral habitat preference for the C. sinyineensis group by way of stochasitc character mapping (SCM) indicates that karstic environments were the ancestral condition out of which the general habitat preference of the ancestor of C. maelanoi sp. nov. and C. inthanon and that of C. amphipetreaus and C. doisuthep evolved three times independently. Additionally, SCM demonstrated that the evolution of a granitic habitat preference from a karst-adapted ancestor happened in C. aequalis. The discovery of a new upland species in the Thai Highlands brings into focus the understudied nature of the mountain systems of western Thailand and the need for their continued exploration and conservation.

Species of Paramyrothecium that are reported as plant pathogens and cause leaf spot or leaf blight have been reported on many commercial crops worldwide. In 2019, during a survey of fungi causing leaf spots on plants in Chiang Mai and Mae Hong Son provinces, northern Thailand, 16 isolates from 14 host species across nine plant families were collected. A new species Paramyrothecium vignicola sp. nov. was identified based on morphology and concatenated (ITS, cmdA, rpb2, and tub2) phylogeny. Further, P. breviseta and P. foliicola represented novel geographic records to Thailand, while P. eichhorniae represented a novel host record (Psophocarpus sp., Centrosema sp., Aristolochia sp.). These species were confirmed to be the causal agents of the leaf spot disease through pathogenicity assay. Furthermore, cross pathogenicity tests on Coffea arabica L., Commelina benghalensis L., Glycine max (L.) Merr., and Dieffenbachia seguine (Jacq.) Schott revealed multiple host ranges for these pathogens. Further research is required into the host–pathogen relationship of Paramyrothecium species that cause leaf spot and their management. Biotic and abiotic stresses caused by climate change may affect plant health and disease susceptibility. Hence, proper identification and monitoring of fungal communities in the environment are important to understand emerging diseases and for implementation of disease management strategies.

The phonetic realization of nasal vowels produced by Pwo speakers of different ages can vary. The present study investigated mid and low nasal vowels of Pwo speakers from Mae Hong Son province, Thailand. Due to the higher tendency of language contact with Thai, the younger group’s nasal vowels were expected to lose more nasality than the older group. The emergence of final nasal consonants was also expected in the younger group. The nasalization duration and consonant duration of both groups were analyzed. The results showed that, regardless of age, mid nasal vowels of some speakers had final nasal consonants, while low nasal vowels of all speakers did not. Furthermore, the older group had both longer nasalization duration and consonant duration than the younger group, suggesting their higher tendency to preserve nasality. The younger group had shorter nasalization duration and consonant duration, indicating the loss of nasality in vowels without compensatory final nasal consonants. The change might be due to the vowel quality. High vowels were fully denasalized with no compensatory final nasal consonants. Mid vowels were nasalized with the emergence of final nasal consonants. Low vowels remained nasalized without final nasal consonants. We could not confirm that the emergence of final nasal consonants was induced by Thai because it occurred in both groups. The existence of final nasal consonants in the younger group could not be used as evidence of an effect of contact.

The promotion of tourism by the government and the creation of local tourist attractions are becoming extremely popular. This has direct negative impacts on the environment, especially the existence of a significant quantity of garbage and its ineffective management. The upstream areas that experience considerable tourism often face problems in solid waste management (SWM), especially in areas with management limitations. The purpose of this study is to study the various important factors that affect the efficiency of SWM from tourism in the upstream areas by exploring the attitudes of those involved in the Pai district, Mae Hong Son Province, using the questionnaire. The questionnaire has been analysed by statistical methods using the SPSS program, and, then, the data has been analysed by 16 experts from 8 related fields using the analytical hierarchy process (AHP) to prioritise the factors affecting the efficiency of waste management from tourism in upstream areas. The study indicated that a total of 30 factors were grouped into 5 groups. The highest important factor is personnel and knowledge, followed by budget and equipment, area and strategy, cooperation and process, and economy and society. Executive vision is the most important secondary factor towards SWM resulting from tourism in the upstream areas. The summary of this research can be used to effectively drive spatial work, which is suitable for small cities located in upstream areas, and growth in tourism, and such information can be applied to other areas that have similar characteristics, which will lead to efficient spatial SWM.

This study evaluated the variation in bioactive compounds (anthocyanins, phenols, and antioxidants) among 22 rice varieties in the same growing locations and among four varieties collected from eight different provinces in Northern Thailand. Wide variation in anthocyanins, phenols, and antioxidant capacity was established, ranging from 1.6 to 33.0 mg/100 g, 249.9 to 477.7 mg gallic acid/100 g, and 0 to 3,288.5 mg trolox equivalent/100 g, respectively. The highest straw anthocyanin and phenol concentrations were found in KDK (a traditional photoperiod-sensitive variety with purple pericarp and leaves) and K4 (an advanced, photoperiod-insensitive variety with purple pericarp and leaves), while the highest antioxidant capacity was found in KH CMU (an improved traditional photoperiod sensitive variety with a purple pericarp and green leaves) and K4. The variation of the bioactive compounds was also found in the same variety grown at different locations, e.g., the KDMl105 grown in Prayao province had a straw anthocyanin concentration higher than when grown in Mae Hong Son province. The effect was also observed in phenol content and antioxidant capacity when the same rice variety was grown across various locations. A significant correlation between total phenol and antioxidant capacity was observed across rice varieties and growing locations but was not found between anthocyanin and antioxidant capacity. This study found that the bioactive compounds in rice straw varied among rice varieties and growing locations. Straw phenol acts as a major antioxidant that can be used as a characteristic for the selection of rice varieties with high antioxidant capacity for use at the industrial scale for the processing of food, pharmaceuticals, and medicinal products.

The aging society of farmers and lack of motivation to pursue a farming career among farmers’ young heirs could induce a severe labor shortage crisis in the farming sector in Thailand in the near future, especially in the upper northern region, which has been officially declared as the base of the organic agricultural production of the country. The main problem is the decision of farmers’ heirs to inherit or not inherit the farming career of their families. The relevant factors and their effects on the decision must be investigated and analyzed. A set of descriptive statistical tools were used to analyze the significance of each factor. A prediction model based on logistic regression was applied to analyze how sensitive of each factor is to the decision to inherit the family farming career. The discovered results could help the federal organization to plan and establish an appropriate strategy in order to cope with the crisis. Here, there are 519 surveyed samples referring to farmers’ heirs from five provinces in the upper northern region, which are Chiang Mai, Chiang Rai, Nan, Lamphun, and Mae Hong Son. The data were collected using a questionnaire. The following 10 relevant factors were found to have direct impacts on the decision to inherit the farming career: gender, increased age, marital status, increased yearly income, the chance to obtain advice from the Federal Department of Agricultural Extension, attitudes towards the farming career, an increase in the land size for farming per family, increase in the land size for farming in the rural area, the variety of agricultural products produced by the family, and an increased set of farming equipment and tools possessed by the family. However, an increase in the number of new family members could lead to unwillingness to inherit the farming career. All these factors in both the willing and unwilling groups had a statistical significance at the level of 0.05. Since the sample size of the willing group was considerably larger than the sample size of the unwilling group, a technique of minority oversampling was adopted to alleviate the problem of the imbalanced datasets. The classification accuracy obtained was 77.56. In addition to the federal planning and strategies applied to ease the crisis, the factors discovered in this study can be used as a stimulus for persuading and stimulating the young generation to inherit the farming career or become a skillful as well as knowledgeable professional farmer capable of producing high-quality agricultural products for the upper northern region of Thailand.

This article points to the importance of religion for refugees and the migration process. After World War II and civil war in China, many refugees flocked to Hong Kong (HK) for safe haven in the British colony, and possible subsequent migration abroad. Christian congregations in HK, and missionaries who themselves were refugees from China, offered hospitality and support services across refugee groups. They advocated for the colonial government to help settle refugees by building low-cost urban housing, schools, medical clinics and new infrastructure. This new workforce was crucial to HK’s industrialization which took-off in the 1950s. With the decline of HK’s trade economy due to the Cold War embargo of China, many refugees became entrepreneurs-of-necessity by starting family businesses that absorbed migrant labour. Religiously-inspired assistance to refugees, from within one’s group and beyond, made a big difference in assimilating newcomers and helping them to rebuild their lives in adverse conditions. Beyond Christian responses, the article also explores the role of the Wong Tai Sin Taoist temple in Kowloon, itself uprooted from Guangzhou and replanted in HK. It reassured displaced people with cultural continuity to their ancestor halls and offered psycho-social assistance through spirit-writing divination, herbal medicine and Taoist worship adapted from rural Chinese villages to urban workers struggling to improve their lives and adapt to Hong Kong.

<p>La transferencia de plántulas de mora de condiciones <em>in vitro </em>a <em>ex vitro </em>es una de las fases más críticas de la técnica de micropropagación debido al alto grado de mortalidad de plántulas (50 a 90%), como consecuencia de una cutícula poco desarrollada, estomas no funcionales y un sistema radical débil que facilita la deshidratación por estrés hídrico. Esta investigación se orientó a la obtención de plántulas limpias procedentes de cultivo de tejidos y endurecidas con micorrizas arbusculares (HMA). La investigación se realizó bajo condiciones controladas; se utilizó un diseño experimental de bloques completos al azar con ocho tratamientos, tres repeticiones y cuatro unidades experimentales, así: tres tratamientos testigo sin inoculación, sin fertilizar (T0), con 50% de fertilización (T50), y con 100% de fertilización (T100), y cinco tratamientos inoculados con HMA (MA1, MA2, MA3, MA4 y Mycobiol) más T50. Los mayores beneficios de la inoculación con HMA se lograron con la cepa MA4 aislada de Silvania (Cundinamarca) y con esporas nativas clasificadas como <em>Glomus </em>sp. y <em>Acaulospora </em>sp. Las plantas inoculadas mostraron mejor adaptación al ambiente, expresada en el porte, la acumulación de biomasa foliar y radical, mayor área foliar y mejor estado nutricional expresado en una mayor absorción de nutrientes esenciales (P, N, Ca y Mg). El uso de la cepa MA4 permitió sustituir el 50% de la fertilización comercial debido a que obtuvo valores similares a T100 en la absorción de P y Ca, y superiores a ésta en la absorción de N y Mg. Este comportamiento vegetal se explicó por los niveles de colonización del hongo en las raíces.</p><p> </p><p><strong>Effect of arbuscular mycorrhizas on the acclimation and hardening of microplantlets of Andean blackberry (Rubus glaucus)</strong></p><p>The transfer of Andean blackberry plantlets from in vitro to ex vitro conditions is one of the most critical phases of the micropropagation technique due to the high mortality rate of plantlets (50-90%), as a consequence of a poorly developed cuticle, non-functional stomates and a weak radicle system that facilitates dehydration by water stress. This investigation focused on obtaining clean plantlets originated from tissue culture and hardened with arbuscular mycorrhizas (HMA). The research was performed under controlled conditions; an experimental design of random complete blocks was used with eight treatments, three repetitions and four experimental units as follows; three control treatments without inoculation, without fertilizing (T0), with 50% fertilizing (T50) and with 100% fertilizing (T100), and five treatments inoculated with HMA (MA1, MA2, MA3, MA4 and Mycobiol®) plus T50. The major benefits of inoculation with HMA were achieved with the strain MA4 isolated from Silvania (Cundinamarca) and with native spores classified as Glomus sp. and Acaulospora sp. The inoculated plants showed better adaptation to the environment, reflected in plant size, accumulation of foliar and radicle biomass, wider foliar area, and better nutritional state reflected in a higher absorption of essential nutrients (P, N, Ca, and Mg). The use of the strain MA4 allowed the substitution of 50% of commercial fertilization since it achieved similar values to T100 in the absorption of P and Ca, and higher absorption for N and Mg. The levels of root colonization by the fungus explained this vegetative behavior. </p>

Education is an effort made by humans to hone and maximize the potential that is in them. So to support the achievement of the educational goals listed in the law it is necessary to have good collaboration from various elements of education including educators and students as actors in realizing educational goals. the existence of an independent curriculum is also an effort by the government to overcome the setback in education which is the impact of the existence of covid. In the Independent Curriculum, principals and educators are given the freedom to develop lesson plans, implement learning and develop curricula based on the needs of students. assessment is the initial step for evaluating and planning further learning, in general the purpose of the assessment is to see the learning outcomes of students. Assessment in the independent curriculum is completely left to educators in which the form of assessment is divided into two, namely formative and summative assessment. English is a tool for communicating orally and in writing. The approach used in this study is a qualitative approach. While the type of research used in this research is descriptive by using purposive sampling technique. The data collection method includes three stages, namely observation, interviews and documentation. Data analysis techniques namely data reduction, data presentation, drawing conclusions. Meanwhile, to test the validity of using source triangulation and technique triangulation. With the results of the research that the implementation of the independent curriculum at SDN 07 Kaliwining rambipuji received a good response with the implementation of various assessments listed in the independent curriculum such as written tests, oral tests, portfolios and projects in learning English, and supported by the existence of worksheets for support student knowledge and facilitate educator assessment.

Mount Fansipan, situated in the Hoang Lien Son Range, supports a rich subtropical and temperate flora of over 1700 species, including 25% of Vietnam’s endemic plant taxa (Nguyen & Harder 1996, Sterling et al. 2006). At elevations above 2000 m, Mount Fansipan contains numerous temperate genera including Acer Linnaeus (19 spp., Sapindaceae Jussieu), Alnus Miller (A. nepalensis, Betulaceae Gray), Betula Linnaeus (B. alnoides Buchanan-Hamilton, Betulaceae), Carex Linnaeus (36 spp., Cyperaceae Jussieu), Clematis Linnaeus (9 spp., Ranunculaceae Jussieu), Lithocarpus Blume (13 spp., Fagaceae Dumortier), Quercus Linnaeus (9 spp., Fagaceae), Rhododendron Linnaeus (40 spp., Ericaceae Jussieu), Rubus Linnaeus (36 spp., Rosaceae Jussieu), Tsuga Carrière (T. dumosa Eichler, Pinaceae Sprengel ex F. Rudolphi), Ulmus Linnaeus (U. lancifolia Roxburgh, Ulmaceae Mirbel), Vaccinium Linnaeus (12 spp., Ericaceae), and Viola Linnaeus (12 spp., Violaceae Batsch) (Vietnam Plant Data Center 2015, Nguyen & Harder 1996) with many of these genera being both species-rich and locally common (Nguyen & Harder 1996, pers. obs.). In April 2012, a collection of a specimen, representing the temperate genus Luzula de Candolle (1805: 158), was made while conducting botanical studies on the Carex flora of Mount Fansipan, Lao Cai Province, Vietnam, which is about 30 km south of the border with Yunnan Province, China. While the specimen was immediately recognized as a Luzula, a new genus to the flora of Vietnam (Vietnam Plant Data Center 2015), it was not until our collection was identified using the keys in Wu & Clements (2000) and Kirschner (2002) that it was determined to be Luzula effusa Buchenau (1879: 88) (Figs. 1, 2). A Basic Alignment Search Tool (BLAST) search of an internal transcribed spacer region (ITS1+5.8S+ITS2) sequence obtained from our specimen (KM612280) showed a 100% match with an existing sequence for L. effusa var. chinensis (Brown 1903: 161) Wu (1992: 92) (AY727778.1, see Drábková & Vlcek 2010) in GenBank (National Center for Biotechnology Information 2014), supporting our identification based on morphology (Table 1). Eighteen other Luzula accessions, representing species placed in two different subgenera and four different sections, were found to have 100% coverage and 99% identity with the sequence from our specimen (National Center for Biotechnology Information 2014) (Table 1). In all cases, these sequences came from taxa that occur in regions that are more geographically disparate from Vietnam than the previously known closest location for L. effusa (see below). These taxa are also morphologically dissimilar to our specimen (see text below and Table 1).

Research objectives: This article discusses Joči’s military-political role and status in the Mongol Empire (Yeke Mongol Ulus), beginning in the early thirteenth century and within the intra-dynastic relations of Činggis Khan’s chief sons. In particular, the article seeks to answer questions about Joči’s birth. Discrepancies between the Secret History of the Mongols and other written sources cast doubt on whether Joči was even a legitimate son of Činggis Khan, let alone his eldest one. In addition, this article includes an analysis of Joči’s place within the family and the traditional legal system of the medieval Mongols based on the principles of majorat succession outlined in the Mongol Empire. It establishes evidence of his legitimacy within the Činggisid dynasty’s imperial lineage (altan uruġ) – a point of view supported by his military-political career, his pivotal role in the western campaigns, his leadership at the siege of Khwārazm, and the process of division of the ulus of Činggis Khan. Research materials: This article makes use of Russian, English, and Turkic (Kazakh, Tatar, etc.) translations of key primary sources including the Secret History of the Mongols and works of authors from the thirteenth to seventeenth centuries, including Al-Nasawī, Shіhāb al-Dīn al-Nuwayrī, ‘Alā’ al-Dīn ’Aṭā-Malik Juvāynī, Minhāj al-Dīn Jūzjānī, Zhao Hong, Peng Daya, John of Plano Carpini, William of Rubruck, Jamāl al-Qarshī, Rashīd al-Dīn, Ibn Faḍl Allāh al-ʿUmarī, Uluġbeg, Ötämiš Hājī, Lubsan Danzan, Abu’l-Ghāzī, and Saγang Sečen. New secondary works regarding Joči published by modern Kazakh, Russian, Tatar, American, French, Chinese, Korean and other scholars were also consulted. Results and novelty of the research: Taking into consideration certain economic and legal traits of the medieval Mongols, their traditional practices, military-political events, and longterm developments in the Mongol Empire’s history, descriptions of Joči being no more than a “Merkit bastard” are clearly not consistent. The persisting claims can be traced to doubts about Joči’s birth included in the Secret History of the Mongols, the first extensive written record of the medieval Mongols which had a great impact on the work of later historians, including modern scholars. Some researchers suspect this allegation may have been an indirect result of Möngke Khan inserting it into the Secret History. This article argues that the main motivation was Batu’s high military-political position and prestige in the Yeke Mongol Ulus. After Ögödei Khan’s death, sons and grandsons of Ögödei and Ča’adai made various attempts to erode Batu’s significant position in the altan uruġ by raising questions regarding his genealogical origin. This explains why doubts about Joči’s status in the imperial lineage appeared so widely following his death in an intra-dynastic propaganda struggle waged between the houses of Joči and Тolui and the opposing houses of Ča’adai and Ögödei’s sons. This conflict over the narrative was engendered by the struggle for supreme power in the Mongol Empire and the distribution of conquered lands and property.

This year’s history matching and forecasting selections, made by reviewer Gopi Nalla of DeGolyer and MacNaughton, reflect the importance of accurate and innovative methodology in the approach toward development of unconventional or challenging plays, from tight oil to highly heterogeneous gas fields to coalbed methane. The authors of paper URTEC 208352 evaluate and compare the performance of rate-normalization and pressure-deconvolution techniques for both synthetic and tight-oil examples. While the synopsis is devoted mostly to the authors’ work in applying these techniques to synthetic cases, much of the complete paper is devoted to tight-oil examples. Ultimately, the authors recommend the pressure-deconvolution approach generally. In paper SPE 207933, the authors apply an integrated approach of using reservoir pressure/gas compressibility (P/Z) calculations to obtain a field gas initially in place (FGIIP) estimation that is then incorporated into an integrated asset model. The technique is applied to a giant onshore gas field. The authors conclude that the new FGIIP estimation can be applied as a reference to re-review the static modeling legacy and to narrow static modeling uncertainties, leading to reliable forecasting and more-efficient field development. An application of the iterative ensemble Kalman smoother to a scenario involving horizontal coalbed-methane wells for a low-permeability field in Australia is the subject of paper URTEC 208291. A forecast study was conducted to validate the history-matched ensemble, with the results showing a good match of 12 months of the new production data not used in history matching, highlighting the robust prediction capabilities of the presented approach. SPE papers continue to a be a vital resource for industry professionals; arguably, such work is more important than ever as the industry and the world adjusts to new modes of collaboration and realities in both the office and the field. I invite you to read the full text of these papers on OnePetro and to find further recent works that advance the literature of this specialized but critical Tech Focus topic. Recommended additional reading at OnePetro: www.onepetro.org. URTEC 208361 - Effect of Relative Permeability on Modeling of Shale Oil and Gas Production by Hamid Behmanesh, University of Calgary, et al. SPE 204835 - Successful Case Study of Machine-Learning Application To Streamline and Improve History-Matching Process for Complex Gas-Condensate Reservoirs in Hai Thach Field, Offshore Vietnam by Son Hoang, Bien Dong Petroleum Operating Company, et al. SPE 207855 - Unleashing the Potential of Relative Permeability Using Artificial Intelligence by Abdur Rahman Shah, Schlumberger, et al.

Abstract Background: Adoptive cellular therapies (ACT) have met with significant success in hematologic malignancies. The number of ACT trials in solid tumors has been increasing, however data are limited on the overall safety and efficacy of ACT in this population. We aimed to conduct a systematic review and meta-analysis looking specifically at TCR and CAR-T in solid tumors and rates of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) relative to the current approved agents in hematologic malignancies. Methods: We conducted a systematic review of published studies/abstracts from January 2015 up to and including July 2021, selecting those that included ≥ 5 patients. Endpoints included rates and differences in CRS and ICANS. Response rates were evaluated. Statistical tests in the pooled data included χ2 and multivariable logistic regression. Results: This meta-analysis included a total of 1,250 patients [566 patients with solid tumors who had received ACT in phase I, II or I/II clinical trials; a comparison was made with five phase 2 clinical trials in hematologic malignancies used for the first FDA approvals of these agents (JULIET, ZUMA-1, ZUMA-2, TRANSCEND and KARMMA), encompassing 684 heme malignant patients]. Rates of CRS of any grade, CRS ≥ grade 3, ICANS of any grade, and ICANS ≥ grade 3 in solid tumors were 33.0%, 3.8%, 2.3% and 2.1%, respectively. Fever, hypotension, and hypoxia were experienced by 37.4%, 18.5%, and 8.5% of solid tumor patients, respectively. CRS, ICANS, fever and hypoxia in solid tumor patients did not differ by whether the ACT received was TCR or CAR T. Objective response (ORR = CR + PR) in patients with solid tumors was higher with TCR compared with CAR-T [odds ratio (OR) = 3.1, P=0.001] and with NY-ESO-1 than other targets (OR=2.0, P=0.031). Compared to hematologic patients treated with ACT, solid tumor patients treated with adoptive cellular therapies were significantly less likely to experience CRS of any grade (62.4% vs. 33.0%, P&lt;0.001), CRS ≥ grade 3 (7.3% vs. 3.8%, P=0.043), fever (50.3% vs. 37.4%, P=0.001), hypoxia (34.1% vs. 8.5%, P&lt;0.001) or hypotension (29.5% vs. 18.5%, P=0.006), ICANS of any grade (29.7% vs. 2.3%, P&lt;0.001), or ICANS ≥ grade 3 (13.9% vs. 2.1%, P&lt;0.001). However, objective response (20.1% vs. 75.4%, P&lt;0.001) and clinical benefit (CBR = CR + PR + SD) (62.6% vs. 90.9%, P&lt;0.001) rates for ACT were lower in patients with solid tumors than in patients with hematologic malignancies. Conclusions: CRS and ICANs were less prevalent in solid tumor cellular therapies. Based on this analysis, T-cell therapies in solid tumors are relatively safe, but further studies with larger populations and longer follow up are needed to address the role of these treatments in cancer. Citation Format: Mirella Nardo, Ji Y. Son, Goldy G. George, David S. Hong. Safety and efficacy of CAR T and TCR therapies in solid tumors: A systematic review and meta-analysis, including a comparison with five phase II trials in hematologic malignancies used for the first FDA approvals of these agents [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2764.

In 1954, India did a ‘Himalayan Blunder’ of having fallen into China’s trap of accepting Tibet to be a part of China. In ‘1962 Indo- China War’, China’s biggest argument of its having claim over Ladakh was that since Ladakh was a part of Tibet and thus belongs to China. But the historical perspective, altogether, contradicts it. Having annexed Tibet and forcefully occupying Aksai Chin, there was no looking back for China; be it in 1965, 1967, 1987, 2013, 2017; and now in 2020. Every time, the Chinese rulers would invent one lie or the other. Xi Jinping, the present Chinese President, imbibes the qualities of both- Mao Tse Tung, Chinese ideologue, a protagonist of the ‘Expansionist Ideology’ and the philosopher- Sun Yat-sen who wrote “The Art of War” and believed that“The greatest victory is that which requires no battle”. Xi Jinping is an expert in both. He did ‘land grabbing’ not just of India and Tibet rather China has 17 territorial disputes with its neighbours, on land and sea. He has also applied ‘Debt- Diplomacy’; mostly on the nascent, economically weak, fragile democracies to subjugate them without firing a bullet. What to talk of entrapping India’s immediate friendly neighbours under his ‘Debt-net’ by using it as a political ideology called “String of Pearls” (weaning away friendly Indian neighbours with the money power), China has loaned over $ 1.5 trillion(5% of its GDP) to more than 150 countries that make it a bigger lender than even W.B. and IMF that compares it well with the USA. China's stance along LAC fits well with a larger pattern of the ‘Expansionist Ideology of Mao. Modi, unlike Nehru, chose to follow Multi-Alignment and befriended countries both the Indian Ocean Region (IOR) and the South China Sea lying in the periphery of China by garlanding China with a ‘Necklace of Diamonds’ which gave India the strategic access and fast-developing routes to Central Asians, East Asian and South-East Asian countries. Moreover, the USA, India, Australia and Japan formed ‘The Quadrilateral Security Dialogue QUAD’ in case of any emergency. India’s ‘Look East Policy; has paid it the dividends with the USA openly playing the role of a deterrent to China in South China; Australia gave a military base in Cocos Islands, France supplied Rafales and good-humoured Russia, unlike the Russia of 1962, is supplying India with the much needed Military pieces of Equipment while refusing the S-400 to China. The suspected role of China in the pandemic COVID-19 has made it ‘a persona non- grata’ in the eyes of many countries. The anti-democracy Security Law in Hong Kong and the USA’s open support to the ‘Independent Tibet’ and recognizing ‘Taiwan as a Sovereign State’ has threatened ‘One China Principle’ which has resulted in the taming China by India.

Abstract Background: The National Comprehensive Cancer Network guideline on Genetic/Familial High Risk: Breast, Ovarian and Pancreatic Cancer (NCCN) recommends offering increased screening and risk-reduction options to women with a pathogenic/likely pathogenic variant (PV/LPV) in 8 clinically-actionable hereditary breast and ovarian cancer (HBOC) genes: ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, PTEN, and TP53. These options range from biannual clinical breast exams and annual breast MRI screening to risk-reducing mastectomy (RRM) and salpingo-oophorectomy (RRSO). Yet health insurance company policies addressing the medical necessity of genetic testing for these genes vary widely. While some payers have adopted the NCCN testing criteria verbatim, others have made specific changes or have developed their own criteria. We sought to quantify the potential impact of this variability on access to enhanced medical management for carriers of PV/LPV in these 8 HBOC genes in a large cohort of patients undergoing genetic testing at a single commercial laboratory. Methods: We reviewed clinical and family histories for patients undergoing multigene panel testing that included testing for the 8 genes of interest and identified 107,344 patients who met NCCN testing criteria (excluding prostate cancer criteria, which were not assessed in this study) for HBOC (v.2.2021). We then compared the histories of these patients to testing criteria for 3 different payer groups: Aetna, Blue Shield of California/Federal Blue Cross-Blue Shield, and eviCore (used by over 30 payers including AmeriHealth, Highmark and Horizon). These are the largest payer groups in our cohort and together represent 19% of patients tested. For each patient we determined whether they met testing criteria for the 3 payer groups. For individuals found to have a PV/LPV we determined the potential missed management opportunities for those who would not have been tested under each payer’s criteria. In addition, we sought to estimate the maximal impact of this missed management for patients with BRCA PV/LPV (not accounting for patient age or medical history). Results: Among patients meeting NCCN testing criteria for HBOC, 10,10,477 (9.8%) were found to have PVs/LPVs in one of the 8 genes. Under the three payer policies 2% to 10.3% of all patients, and up to 4.0% (n=423) of PV/LPV carriers, would not have been eligible for genetic testing. Based on NCCN management guidelines, up to 423 eligible patients would not have been offered annual breast MRI, 208 patients would not have been offered RRM, and 163 eligible patients would not have been offered RRSO. This lack of testing access due to misaligned medical policies also represents missed opportunities for offering potentially life-saving screening and risk reduction measures to these patients as well. Assuming lifetime cancer risks of 85% for breast cancer and 40% for ovarian cancer, and risk-reduction of 95% with RRM and 80% with RRSO. Had all policies matched NCCN testing criteria, up to 132 breast cancers could have potentially been detected earlier or prevented and 52 ovarian cancers could potentially have been prevented in our cohort. Conclusions: In addition to complicating clinical practice, varying testing guidelines have broader implications. Our data show that a significant number of mutation carriers are being missed by payer policies that deviate from NCCN testing criteria. In turn, this represents missed opportunities to offer proactive screening and risk-reduction options that could potentially save lives for those at risk for hereditary cancer. Based on findings from other studies, these actions would likely reduce health insurer costs as well. Citation Format: Robert T Pilarski, Stephanie Noble, Lily Hoang, Randy Hew, Stephanie Gandomi, Holly LaDuca, Jill Dolinsky. Inequitable access to genetic testing leads to missed screening and prevention opportunities for individuals at risk for hereditary breast and ovarian cancer [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-09-19.

Abstract Background: CTX + dual HER2-targeting monoclonal antibodies (mAb) remains a standard of care for treatment (Tx) of both HER2+ early-stage and MBC. However, when the SOPHIA trial was launched, limited Tx options existed after progression on T, pertuzumab (P), and ado-trastuzumab emtansine. M, an Fc-engineered anti-HER2 mAb, targets the same epitope as T and exerts similar antiproliferative effects. M enhances CD16A-mediated ADCC compared to T. Furthermore, M treatment is associated with increased HER2-specific T- and B-cell responses and increased T-cell clonality compared to baseline. The phase 3 SOPHIA (NCT02492711) study demonstrated PFS benefit of M vs T, both + CTX, in HER2+ MBC pts. M improved PFS over T, with a 24% relative risk reduction (HR .76; 95% CI .59-.98; P=.033; median, 5.8 [95% CI 5.5-7.0] months (mo) vs 4.9 [95% CI 4.2-5.6] mo (Rugo HS, et al. JAMA Oncol 2021), resulting in FDA approval. Median OS after 270 mortality events (2nd interim analysis) was 21.6 mo with M vs 19.8 mo with T (HR .89; 95% CI .69-1.13; P=.33). Here we report final OS after 385 events, as well as updated safety.Methods: Pts with disease progression after ≥2 lines of anti-HER2 Tx, including P, and 1-3 lines of Tx for HER2+ MBC were randomized 1:1 to CTX + either M (15 mg/kg) or T (8 mg/kg loading dose, then 6 mg/kg), both given IV every 3 weeks. Randomization was stratified by number of metastatic sites (≤2, &gt;2), lines of Tx for MBC (≤2, &gt;2), and CTX choice (capecitabine, eribulin, gemcitabine, or vinorelbine). Sequential primary end points were central-blinded review of PFS and OS.Results: The intent-to-treat (ITT) population comprised 536 pts (M, 266; T, 270). At the median follow-up of 20.2 mo among all ITT pts, pts received a median of 7 cycles of M + CTX vs 6 cycles of T + CTX. Median OS after 385 events in the ITT population was 21.6 mo with M vs 21.9 mo with T (HR .95; 95% CI .77-1.17; P=.62; Table). Based on a prespecified, non-α-allocated exploratory analysis, a numerical OS advantage in favor of the M arm was observed in the subgroup of pts homozygous for the CD16A-158F low-affinity allele (median OS, 23.6 vs 19.2 mo; HR .72; 95% CI .52-1.00; nominal P=.05). In contrast, in the small subgroup of CD16A-158V homozygotes, median OS was longer for T vs M (31.1 mo vs 22.0 mo; HR 1.77; 95% CI 1.01-3.12; nominal P=.04). Grade ≥3 adverse events (AE) occurred in 146 pts (55.3%) receiving M vs 141 pts (53.0%) receiving T. Serious AEs were seen in 47 pts (17.8%) receiving M vs 51 pts (19.2%) receiving T. Incidence of infusion-related reactions was higher with M (36 [13.6%]) vs T (9 [3.4%]). Left ventricular dysfunction requiring delay or cessation of M/T administration occurred in 4 pts (1.5%) receiving M and in 7 pts (2.6%) receiving T. Conclusions: The median OS in the ITT population was not statistically different between the 2 arms. An exploratory analysis of CD16A genotyping indicates a numerical OS advantage in favor of M in F homozygous pts, along with a numerical OS advantage in favor of T in V homozygous pts. Safety of M + CTX was similar to previous reports and consistent with M FDA-approved label. Studies of M in HER2+ breast cancer pts with different CD16A allelic variants are warranted, including MARGOT, the neoadjuvant investigator-initiated study on the efficacy of M vs T in pts carrying F-allelic variants of CD16A. Median OSITT analysisPrespecified, non-α-allocated exploratory analysis (n=506)N=536CD16A-158F carriers (F/F and F/V)(n=437)CD16A-158F homozygotes (F/F)(n=192)CD16A-158F/V heterozygotes(n=245)CD16A-158V homozygotes (V/V)(n=69)aM + CTX, mo21.6 (n=266)23.3 (n=221)23.6 (n=102)21.3 (n=119)22.0 (n=37)T + CTX, mo21.9 (n=270)20.8 (n=216)19.2 (n=90)22.0 (n=126)31.1 (n=32)HR (95% CI)0.95 (0.77-1.17)0.86 (0.69-1.08)0.72 (0.52-1.00)0.96 (0.71-1.30)1.77 (1.01-3.12)P value0.620.19b0.05b0.78b0.04bAbbreviations: CTX, chemotherapy; HR, hazard ratio; ITT, intent to treat; M, margetuximab; mo, months; OS, overall survival; T, trastuzumab. Cutoff date: June 14, 2021. aThis subgroup was characterized by an imbalance in poor prognostic features. bNominal P value. Citation Format: Hope Rugo, Seock-Ah Im, Fatima Cardoso, Javier Cortes, Giuseppe Curigliano, Antonino Musolino, Mark D. Pegram, Thomas Bachelot, Gail S. Wright, Cristina Saura, Santiago Escrivá-de-Romaní, Michelino De Laurentiis, Gary N. Schwartz, Timothy Pluard, Francesco Ricci, William Gwin, III, Christelle Levy, Ursa Brown-Glaberman, Jean-Marc Ferrero, Maaike de Boer, Sung-Bae Kim, Katarína Petráková, Denise A. Yardley, Orit Freedman, Erik H. Jakobsen, Einav Nili Gal-Yam, Rinat Yerushalmi, Peter A. Fasching, Emily Ashley, Shengyan Hong, Minori Rosales, William J. Gradishar. Phase 3 SOPHIA study of margetuximab (M) + chemotherapy (CTX) vs trastuzumab (T) + CTX in patients (pts) with HER2+ metastatic breast cancer (MBC) after prior anti-HER2 therapies: Final overall survival (OS) analysis [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD8-01.

Can Gio mangrove forest (CGM) is located downstream of Ho Chi Minh City (HCMC), situated between an estuarine system of Dong Nai - Sai Gon river and a part of Vam Co river. The CGM is the largest restored mangrove forest in Vietnam and the UNESCO’s Mangrove Biosphere Reserve. The CGM has been gradually facing to numeric challenges of global climate change, environmental degradation and socio-economic development for the last decades. To evaluate sediment quality in the CGM, we collected 13 cores to analyze for sediment grain size, organic matter content, and trace element concentration of Cd, Cr, Cu, Ni, Pb, Zn. Results showed that trace element concentrations ranged from uncontaminated (Cd, Cu, and Zn) to very minor contaminated (Cr, Ni, and Pb). The concentrations were gradually influenced by suspended particle size and the mangrove plants.ReferencesAnh M.T., Chi D.H., Vinh N.N., Loan T.T., Triet L.M., Slootenb K.B.-V., Tarradellas J., 2003. 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The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or indirectly involved events in precipitating mental health issues. The human species is a wanderer and hunter-gatherer by nature, and physical social distancing and nationwide lockdown have confined an individual to physical isolation. The present review article was conceived to address psychosocial and other issues and their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath of SARS-CoV-2, and social isolation as a preventive measure may further induce mental health issues. Animal model studies have demonstrated an inappropriate interacting endogenous neurotransmitter milieu of dopamine, serotonin, glutamate, and opioids, induced by social isolation that could probably lead to observable phenomena of deviant psychosocial behavior. Conflicting and manipulated information related to COVID-19 on social media has also been recognized as a global threat. Psychological stress during the current pandemic in frontline health care workers, migrant workers, children, and adolescents is also a serious concern. Mental health issues in the current situation could also be induced by being quarantined, uncertainty in business, jobs, economy, hampered academic activities, increased screen time on social media, and domestic violence incidences. The gravity of mental health issues associated with the pandemic of COVID-19 should be identified at the earliest. Mental health organization dedicated to current and future pandemics should be established along with Government policies addressing psychological issues to prevent and treat mental health issues need to be developed. References World Health Organization (WHO) Coronavirus Disease (COVID-19) Dashboard. 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The Mae Hong Son Fault (MHSF) is a north-trending active fault in northern Thailand. The largest earthquake ever recorded in Thailand occurred in February 1975 with a magnitude of 5.6 and was associated with the southern end of the MHSF. Paleoearthquake magnitudes, recurrence intervals, and slip rates for the MHSF are evaluated using the morphological characteristics of the MHSF aided with a 12.5-m-resolution digital elevation model (DEM) and using fault trenching. Morphotectonic analysis, including studies of offset streams, linear valleys, triangular facets, and fault scarps, helps illustrate dextral fault movements within the MHSF zone. Two separated N–S trending basins, the Mae Hong Son to the north and the Mae Sariang to the south, are present along the MHSF. Between these basins, fault displacements decrease toward the Khun Yuam area. Surface rupture length investigation from fault segments in both basins indicates maximum credible earthquake magnitudes between 5.8 and 6.3. Fault trenching and road-cut studies show that nine earthquakes occurred along the MHSF over the past ∼43 ka. Optically stimulated luminescence (OSL) dating help define the timing of the earthquakes to ∼43, ∼38, ∼33, ∼28, ∼23, ∼18, ∼13, ∼8, and ∼3 ka. The recurrence interval of earthquakes on the Mae Hong Son Fault is ∼5,000 years and the fault has a slip rate of ∼0.04–0.15 mm/a.