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1

E, Lewis Claire, and McGee J. O'D, eds. The Macrophage. Oxford: IRL Press at Oxford University Press, 1992.

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2

Kloc, Malgorzata, ed. Macrophages. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-54090-0.

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Rousselet, Germain, ed. Macrophages. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7837-3.

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Röszer, Tamás. The M2 Macrophage. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-50480-9.

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5

1943-, Zwilling Bruce S., and Eisenstein Toby K, eds. Macrophage-pathogen interactions. New York: M. Dekker, 1994.

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6

Herbein, Georges. HIV and the macrophage. Kerala, India: Transworld Research Network, 2007.

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7

Gupta, Swati, and Yashwant V. Pathak, eds. Macrophage Targeted Delivery Systems. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84164-5.

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8

Russell, Stephen W., and Siamon Gordon, eds. Macrophage Biology and Activation. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77377-8.

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9

Harris, James, and Eric F. Morand, eds. Macrophage Migration Inhibitory Factor. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-4939-9936-1.

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10

1929-, Staub Norman C., ed. The Pulmonary intravascular macrophage. Mount Kisco, NY: Futura Pub. Co., 1989.

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11

Rossi, Bartira Consini. Macrophage function in African trypanosomiasis. Uxbridge: Brunel University, 1986.

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12

Gordon, Siamon, ed. The Macrophage as Therapeutic Target. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-642-55742-2.

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13

Damoiseaux, Jan G. M. C., ed. Macrophage heterogeneity established by immunocytochemistry. Stuttgart: Gustav Fischer, 1993.

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14

Thorsten, Hagemann, and SpringerLink (Online service), eds. Tumour-Associated Macrophages. New York, NY: Springer Science+Business Media, LLC, 2012.

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15

Lawrence, Toby, and Thorsten Hagemann, eds. Tumour-Associated Macrophages. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-0662-4.

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16

David, Evered, Nugent Jonathan, O'Connor Maeve, Ciba Foundation, and Symposium on Biochemistry of Microphages (1985 : Ciba Foundation), eds. Biochemistry of macrophages. Chichester: John Wiley, 1986.

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17

Reiner, Neil E., ed. Macrophages and Dendritic Cells. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-396-7.

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18

Horton, Michael A., ed. Macrophages and Related Cells. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4757-9534-9.

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19

Nicholls, S. E. Control of granulocyte / macrophage progenitor cells bygrowthfactors. Manchester: UMIST, 1993.

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20

Voronov, Irina. Macrophage phagocytosis of polyethylene particulate in vitro. Ottawa: National Library of Canada, 1997.

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21

Perry, V. Hugh. Macrophages and the nervous system. Austin: R.G. Landes Co., 1994.

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22

Harris, J. R., ed. Megakaryocytes, Platelets, Macrophages, and Eosinophils. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4757-9531-8.

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23

R, Harris James, ed. Megakaryocytes, platelets, macrophages, and eosinophils. New York: Plenum Press, 1991.

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24

Paladi, Magdalena. A genetic analysis of Drosophila embryonic macrophage migration. Ottawa: National Library of Canada, 2003.

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25

The human macrophage system: Activity and functional morphology. Basel: Karger, 1988.

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26

Murphy, Colin J. The importance of glutamine metabolism to macrophage function. Dublin: University College Dublin, 1997.

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27

(Editor), Bernard Burke, and Claire E. Lewis (Editor), eds. The Macrophage. 2nd ed. Oxford University Press, USA, 2002.

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28

Bernard, Burke, and Lewis Claire E, eds. The macrophage. 2nd ed. Oxford: Oxford University Press, 2002.

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29

Adams, Dolph O. Macrophage Activation. Springer, 2013.

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30

Adams, Dolph O. Macrophage Activation. Springer, 2013.

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31

Röszer, Tamás. M2 Macrophage. Springer International Publishing AG, 2021.

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32

Grom, Alexei A., and Athimalaipet V. Ramanan. Macrophage activation syndrome. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0168.

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Abstract:
Macrophage activation syndrome (MAS) is a life-threatening condition caused by excessive activation and proliferation of T lymphocytes and haemophagocytic macrophages. Although MAS has been reported in association with almost any rheumatic disease, it is by far most common in systemic juvenile idiopathic arthritis. Flares of the underlying disease or infection are most common triggers of MAS. The pathognomonic feature of MAS is typically found in bone marrow: numerous, well-differentiated macrophagic histiocytes phagocytosing normal haematopoietic elements. The expansion of these histiocytes leads to a massive systemic inflammatory reaction associated with three cardinal clinical features: severe cytopenias, liver dysfunction, and coagulopathy consistent with disseminated intravascular coagulation. Clinically, MAS is strikingly similar to the autosomal recessive disorders collectively known as familial haemophagocytic lymphohistiocytosis (FHLH). FHLH has been associated with various genetic defects affecting the cytolytic pathway. Cytolytic function is profoundly depressed in MAS patients as well, and this abnormality is caused by both genetic and acquired factors. Studies in animals suggest that uncontrolled expansion of activated CD8+ T lymphocytes secreting cytokines that activate macrophages is central to the pathophysiology of haemophagocytic syndromes. Consistent with this view, the combination of steroids and ciclosporin, an immunosuppressant that preferentially inhibits T lymphocytes, is an effective treatment for the majority of MAS patients. Patients in whom MAS remains active despite this treatment present a serious challenge and require more aggressive immunosuppression. However, in MAS triggered by infection, the optimal level of immunosuppression is difficult to determine. As a result, reported mortality rates reach 20%.
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33

Paulnock, Donna M. Macrophages. Oxford University Press, 2000.

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34

REICHARD, S. Reichard Macrophage Biology. John Wiley & Sons Inc, 1986.

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35

Clemens, Sorg, and Immunologische Tage. (1987 : Münster, West Germany), eds. The Alveolar macrophage. Münster: Regensberg & Biermann Wissenschaftliche Verlagsgellschaft, 1988.

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36

Bondarenko, Olesja, and Fernando Torres Andón, eds. Nanoparticle-Macrophage Interactions. MDPI, 2022. http://dx.doi.org/10.3390/books978-3-0365-4600-1.

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37

Fink, Mary. Macrophage in Neoplasia. Elsevier Science & Technology Books, 2012.

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38

Röszer, Tamás. The M2 Macrophage. Springer, 2020.

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39

Bucala, Richard. Mif Handbook. World Scientific Publishing Co Pte Ltd, 2012.

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40

Bucala, Richard. Mif Handbook. World Scientific Publishing Co Pte Ltd, 2012.

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41

Gordon, Siamon, and Stephen W. Russell. Macrophage Biology and Activation. Springer London, Limited, 2012.

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42

Nelson, David S. Immunobiology of the Macrophage. Elsevier Science & Technology Books, 2014.

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43

W, Russell Stephen, and Gordon Siamon, eds. Macrophage biology and activation. Berlin: Springer-Verlag, 1992.

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44

Gordon, Siamon, and Stephen W. Russell. Macrophage Biology and Activation. Springer London, Limited, 2011.

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45

Unanue, Emil. Macrophage Regulation of Immunity. Elsevier Science & Technology Books, 2012.

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46

Gordon, Siamon. Macrophage As Therapeutic Target. Springer London, Limited, 2012.

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47

Gordon, Siamon. The Macrophage as Therapeutic Target. Springer, 2012.

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48

The Macrophage as Therapeutic Target. Springer, 2003.

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49

Clemens, Sorg, ed. Macrophage-derived cell regulatory factors. Basel: Karger, 1989.

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50

Hussain Bhat, Khalid, ed. Macrophage Activation - Biology and Disease. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.79065.

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