Academic literature on the topic 'Macaque Neurophysiology'

We describe intracranial local field potentials (LFP) recorded in the anterior cingulate cortex (ACC) of macaque monkeys performing a saccade countermanding task. The most prominent feature at ∼70% of sites was greater negative polarity after errors than after rewarded correct trials. This negative polarity was also evoked in unrewarded correct trials. The LFP evoked by the visual target was much less polarized, and the weak presaccadic modulation was insufficient to control the initiation of saccades. When saccades were cancelled, LFP modulation decreased slightly with the magnitude of response conflict that corresponds to the coactivation of gaze-shifting and -holding neurons estimated from the probability of canceling. However, response time adjustments on subsequent trials were not correlated with LFP polarity on individual trials. The results provide clear evidence that error- and feedback-related, but not conflict-related, signals are carried by the LFP in the macaque ACC. Finding performance monitoring field potentials in the ACC of macaque monkeys establishes a bridge between event-related potential and functional brain-imaging studies in humans and neurophysiology studies in non-human primates.

The paper introduces dyadic brain modelling, offering both a framework for modelling the brains of interacting agents and a general framework for simulating and visualizing the interactions generated when the brains (and the two bodies) are each coded up in computational detail. It models selected neural mechanisms in ape brains supportive of social interactions, including putative mirror neuron systems inspired by macaque neurophysiology but augmented by increased access to proprioceptive state. Simulation results for a reduced version of the model show ritualized gesture emerging from interactions between a simulated child and mother ape.

In texture segregation, an example of scene segmentation, we can discern two different processes: texture boundary detection and subsequent surface segregation [Lamme, V. A. F., Rodriguez-Rodriguez, V., & Spekreijse, H. Separate processing dynamics for texture elements, boundaries and surfaces in primary visual cortex of the macaque monkey. Cerebral Cortex, 9, 406–413, 1999]. Neural correlates of texture boundary detection have been found in monkey V1 [Sillito, A. M., Grieve, K. L., Jones, H. E., Cudeiro, J., & Davis, J. Visual cortical mechanisms detecting focal orientation discontinuities. Nature, 378, 492–496, 1995; Grosof, D. H., Shapley, R. M., & Hawken, M. J. Macaque-V1 neurons can signal illusory contours. Nature, 365, 550–552, 1993], but whether surface segregation occurs in monkey V1 [Rossi, A. F., Desimone, R., & Ungerleider, L. G. Contextual modulation in primary visual cortex of macaques. Journal of Neuroscience, 21, 1698–1709, 2001; Lamme, V. A. F. The neurophysiology of figure ground segregation in primary visual-cortex. Journal of Neuroscience, 15, 1605–1615, 1995], and whether boundary detection or surface segregation signals can also be measured in human V1, is more controversial [Kastner, S., De Weerd, P., & Ungerleider, L. G. Texture segregation in the human visual cortex: A functional MRI study. Journal of Neurophysiology, 83, 2453–2457, 2000]. Here we present electroencephalography (EEG) and functional magnetic resonance imaging data that have been recorded with a paradigm that makes it possible to differentiate between boundary detection and scene segmentation in humans. In this way, we were able to show with EEG that neural correlates of texture boundary detection are first present in the early visual cortex around 92 msec and then spread toward the parietal and temporal lobes. Correlates of surface segregation first appear in temporal areas (around 112 msec) and from there appear to spread to parietal, and back to occipital areas. After 208 msec, correlates of surface segregation and boundary detection also appear in more frontal areas. Blood oxygenation level-dependent magnetic resonance imaging results show correlates of boundary detection and surface segregation in all early visual areas including V1. We conclude that texture boundaries are detected in a feedforward fashion and are represented at increasing latencies in higher visual areas. Surface segregation, on the other hand, is represented in “reverse hierarchical” fashion and seems to arise from feedback signals toward early visual areas such as V1.

Neurons in posterior parietal cortex (PPC) may serve both proprioceptive and exteroceptive functions during prehension, signaling hand actions and object properties. To assess these roles, we used digital video recordings to analyze responses of 83 hand-manipulation neurons in area 5 as monkeys grasped and lifted objects that differed in shape (round and rectangular), size (large and small spheres), and location (identical rectangular blocks placed lateral and medial to the shoulder). The task contained seven stages—approach, contact, grasp, lift, hold, lower, relax—plus a pretrial interval. The four test objects evoked similar spike trains and mean rate profiles that rose significantly above baseline from approach through lift, with peak activity at contact. Although representation by the spike train of specific hand actions was stronger than distinctions between grasped objects, 34% of these neurons showed statistically significant effects of object properties or hand postures on firing rates. Somatosensory input from the hand played an important role as firing rates diverged most prominently on contact as grasp was secured. The small sphere—grasped with the most flexed hand posture—evoked the highest firing rates in 43% of the population. Twenty-one percent distinguished spheres that differed in size and weight, and 14% discriminated spheres from rectangular blocks. Location in the workspace modulated response amplitude as objects placed across the midline evoked higher firing rates than positions lateral to the shoulder. We conclude that area 5 neurons, like those in area AIP, integrate object features, hand actions, and grasp postures during prehension.

Hand manipulation neurons in areas 5 and 7b/anterior intraparietal area (AIP) of posterior parietal cortex were analyzed in three macaque monkeys during a trained prehension task. Digital video recordings of hand kinematics synchronized to neuronal spike trains were used to correlate firing rates of 128 neurons with hand actions as the animals grasped and lifted rectangular and round objects. We distinguished seven task stages: approach, contact, grasp, lift, hold, lower, and relax. Posterior parietal cortex (PPC) firing rates were highest during object acquisition; 88% of task-related area 5 neurons and 77% in AIP/7b fired maximally during stages 1, 2, or 3. Firing rates rose 200–500 ms before contact, peaked at contact, and declined after grasp was secured. 83% of area 5 neurons and 72% in AIP/7b showed significant increases in mean rates during approach as the fingers were preshaped for grasp. Somatosensory signals at contact provided feedback concerning the accuracy of reach and helped guide the hand to grasp sites. In error trials, tactile information was used to abort grasp, or to initiate corrective actions to achieve task goals. Firing rates declined as lift began. 41% of area 5 neurons and 38% in AIP/7b were inhibited during holding, and returned to baseline when grasp was relaxed. Anatomical connections suggest that area 5 provides somesthetic information to circuits linking AIP/7b to frontal motor areas involved in grasping. Area 5 may also participate in sensorimotor transformations coordinating reach and grasp behaviors and provide on-line feedback needed for goal-directed hand movements.

Computer simulations of an extended version of a neural model of lightness perception [1,2] are presented. The model provides a unitary account of several key aspects of spatial lightness phenomenology, including contrast and assimilation, and asymmetries in the strengths of lightness and darkness induction. It does this by invoking mechanisms that have also been shown to account for the overall magnitude of dynamic range compression in experiments involving lightness matches made to real-world surfaces [2]. The model assumptions are derived partly from parametric measurements of visual responses of ON and OFF cells responses in the lateral geniculate nucleus of the macaque monkey [3,4] and partly from human quantitative psychophysical measurements. The model’s computations and architecture are consistent with the properties of human visual neurophysiology as they are currently understood. The neural model's predictions and behavior are contrasted though the simulations with those of other lightness models, including Retinex theory [5] and the lightness filling-in models of Grossberg and his colleagues [6].

The local field potential (LFP) is of growing importance in neurophysiology as a metric of network activity and as a readout signal for use in brain-machine interfaces. However, there are uncertainties regarding the kind and visual field extent of information carried by LFP signals, as well as the specific features of the LFP signal conveying such information, especially under naturalistic conditions. To address these questions, we recorded LFP responses to natural images in V1 of awake and anesthetized macaques using Utah multielectrode arrays. First, we have shown that it is possible to identify presented natural images from the LFP responses they evoke using trained Gabor wavelet (GW) models. Because GW models were devised to explain the spiking responses of V1 cells, this finding suggests that local spiking activity and LFPs (thought to reflect primarily local synaptic activity) carry similar visual information. Second, models trained on scalar metrics, such as the evoked LFP response range, provide robust image identification, supporting the informative nature of even simple LFP features. Third, image identification is robust only for the first 300 ms following image presentation, and image information is not restricted to any of the spectral bands. This suggests that the short-latency broadband LFP response carries most information during natural scene viewing. Finally, best image identification was achieved by GW models incorporating information at the scale of ∼0.5° in size and trained using four different orientations. This suggests that during natural image viewing, LFPs carry stimulus-specific information at spatial scales corresponding to few orientation columns in macaque V1.

AbstractThe validity of the Barten theoretical model for describing the vertebrate spatial contrast sensitivity function (CSF) and acuity at scotopic light levels has been examined. Although this model (which has its basis in signal modulation transfer theory) can successfully describe vertebrate CSF, and its relation to underlying visual neurophysiology at photopic light levels, significant discrepancies between theory and experimental data have been found at scotopic levels. It is shown that in order to describe scotopic CSF, the theory must be modified to account for important mechanistic changes, which occur as cone vision switches to rod vision. These changes are divided into photon management factors [changes in optical performance (for a dilated pupil), quantum efficiency, receptor sampling] and neural factors (changes in spatial integration area, neural noise, and lateral inhibition in the retina). Predictions of both scotopic CSF and acuity obtained from the modified theory were found to be in good agreement with experimental values obtained from the human, macaque, cat, and owl monkey. The last two species have rod densities particularly suited for scotopic conditions.

Consideration of available evidence suggests that primate vision utilises two parallel cortical pathways to process visual information. The ventral pathway processes form or shape information, while the dorsal pathway processes motion information. In the macaque monkey, the superior temporal sulcus in the temporal lobe is one of the few cortical areas that receives input from both these pathways. In this thesis recordings from visually responsive neurons in the macaque superior temporal sulcus are described. The cell response properties of three cell groups are investigated. One cell population show selectivity for the sight of static images of particular views of the body. The second group of cells shows selectivity for the sight of objects moving in the environment, independent of the object's form. The final group of cells show selectivity for particular views of the body providing that they are moving in particular directions. The responses from these three groups of cell types are subjected to an analysis technique that allows insights into possible computational processes underlying the observed neural selectivity's. In particular, it is argued that the primate visual system processes form information primarily in a feedforward way, a property few computational models of visual processing employ. These data are combined with data from other studies to produce a speculative outline for a biologically plausible model of primate visual form processing. The recordings also revealed cell responses to walking bodies that showed a remarkable selectivity for "structure from motion". It is suggested that this selectivity is developed by associative learning between the initially separate form and motion inputs. Investigation of the integration of form and motion information onto single cells indicated a hitherto unforeseen problem: a temporal asynchrony between the arrival times of form and direction information. This asynchrony indicates that previously proposed mechanisms for binding of information about the same object are incorrect.

Nous possédons la faculté de reconnaître individuellement des centaines d'individus. Ceci nous permet d'évoluer dans une société complexe dont l'organisation est en partie forgée par les relations interindividuelles. La reconnaissance individuelle peut être réalisée par l'identification de divers éléments distincts, comme le visage ou la voix, qui forment chez l'Homme une seule représentation conceptuelle de l'identité de la personne. Nous avons démontré que les singes rhésus, comme les humains, reconnaissent individuellement leurs congénères familiers, mais également les individus humains connus. Ceci montre que la reconnaissance fine est une compétence partagée par un éventail d'espèces de primates pouvant servir de fondement à la vie en réseaux sociaux sophistiqués, et également que le cerveau s'adapte de façon flexible pour reconnaître les individus d'autres espèces lorsque ceux-ci ont une importance socioécologique. Par la suite, au niveau neuronal, ce projet a mis en lumière que les connaissances sociales concernant autrui sont représentées par les neurones hippocampiques ainsi que par les neurones inférotemporaux. Ainsi nous avons observé l'existence de neurones sélectifs aux visages non seulement dans le cortex inferotemporal, comme ceci a été décrit précédemment, mais également dans l'hippocampe. La comparaison des propriétés de ces neurones au sein de ces deux structures, suggère que les deux régions joueraient des rôles complémentaires au cours de la reconnaissance individuelle. Enfin, parce que l'hippocampe est une structure qui a évolué à des degrés divers chez différents mammifères pour soutenir la mémoire autobiographique et les représentations spatiales, la caractérisation des différents types de neurones et de leur connectivité a fourni un cadre commun pour comparer les fonctions de l'hippocampe à travers les espèces

The ultimate goal of the nervous systems of all animals is conceptually simple: Manipulate the external environment to maximize one's own survival and reproduction. The myriad means animals employ in pursuit of this goal are astoundingly complex, but constrained by common factors. For example, to ensure survival, all animals must acquire the necessary nutrients to sustain metabolism. Similarly, social interaction of some form is necessary for mating and reproduction. For some animals, the required social interaction goes far beyond that necessary for mating. Humans and many other primates exist in complex social environments, the navigation of which are essential for adaptive behavior. This dissertation is concerned with processes of transforming sensory stimuli regarding both nutritive and social information into motor commands pursuant to the goals of survival and reproduction. Specifically, this dissertation deals with these processes in the rhesus macaque. Using a task in which monkeys make decisions simultaneously weighing outcomes of fruit juices and images of familiar conspecifics, I have examined the neurophysiology of social and nutritive factors as they contribute to choice behavior; with the ultimate goal of understanding how these disparate factors are weighed against each other and combined to produce coherent motor commands that result in adaptive social interactions and the successful procurement of resources. I began my investigation in the lateral intraparietal cortex, a well-studied area of the primate brain implicated in visual attention, oculomotor planning and control, and reward processing. My findings indicate the lateral intraparietal cortex represents social and nutritive reward information in a common neural currency. That is, the summed value of social and nutritive outcomes is proportional to the firing rates of parietal neurons. I continued my investigation in the striatum, a large and functionally diverse subcortical nuclei implicated in motor processing, reward processing and learning. Here I find a different pattern of results. Striatal neurons generally encoded information about either social outcome or juice rewards, but not both, with a medial or lateral bias in the location of social or juice information encoding neurons, respectively. In further contrast to the lateral intraparietal cortex, the firing rates of striatal neurons coding social and nutritive outcome information is heterogeneous and not directly related to the value of the outcome. This dissertation represents a few incremental steps toward understanding how social information and the drive toward social interaction are incorporated with other motivators to influence behavior. Understanding this process is a necessary step for elucidating, treating, and preventing pathologies

Dissertation

The effect of visual attention on neural signals has been extensively studied using various techniques such as macaque neurophysiology and human electro/magneto encephalogram (EEG/MEG). Depending on the technique, different neural measures are typically used for studying attention. For example, in neurophysiology experiments involving macaques, many studies have focused on the modulation in spiking activity or the change in oscillatory power at different frequency bands such as alpha (8-12 Hz) or gamma (30-80 Hz) with attention, or the change in the relationship of spikes with these oscillations. In contrast, human EEG studies, in addition to studying alpha and gamma modulation, often use flickering stimuli that produce a specific neural response called steady-state visually evoked potential (SSVEP), which is also modulated by attention. However, due to the differences in stimuli and task paradigms in such studies, it is difficult to determine the effectiveness of these various neural measures for capturing attentional modulation. To address this, we designed a task paradigm which included both static and counterphase flickering stimuli to generate all the relevant neural measures (alpha/gamma power as well as SSVEPs) under identical recording conditions, which allowed us to compare their effectiveness in studying attention. Since several reports suggest that attention modulates these neural measures through a canonical neural mechanism called normalization, in the first study of this thesis, we varied the normalization strength parametrically as a proxy for attentional modulation and tested its effect on various neural measures. We manipulated normalization strength by presenting static as well as flickering orthogonal superimposed gratings (plaids) at varying contrasts to two female monkeys while recording multiunit activity (MUA) and LFP from the primary visual cortex (area V1). We quantified the modulation in MUA, gamma (32-80 Hz), high-gamma (104-248 Hz) power, and SSVEP. Even under similar conditions, normalization strength was different for the four measures; and increased as: spikes, high-gamma, SSVEP, and gamma. However, these results could be explained using a normalization model, modified for population responses by varying the tuned normalization parameter and semi-saturation constant. In the second part of the thesis, we tested the predictions of the gamma phase coding hypothesis in the context of stimulus contrast and visual attention. The gamma phase coding hypothesis posits that the intensity of the incoming stimulus is encoded in the position of the spike relative to the gamma rhythm. Using chronically implanted microelectrode arrays in the primary visual cortex of macaques engaged in an attention task while presenting stimuli of varying contrasts, we tested whether the phase of the gamma rhythm relative to spikes varied as a function of stimulus contrast and attentional state. We analyzed spikes and LFP from different electrodes and found a weak but significant effect of attention, but not stimulus contrast, on the gamma phase relative to spikes. Although we found a significant effect of attention, we argue that a small magnitude of phase shift as well as the dependence of phase angles on gamma power and center frequency, limits the potential role of gamma in phase coding in area V1. In the third part of the thesis, we recorded EEG signals from 26 human participants while they were engaged in an attention task and analyzed alpha and gamma band powers for both static and flickering stimuli and SSVEP power for flickering stimuli. We report two main results. First, attentional modulation was comparable for SSVEP and alpha. Second, we found that non-foveal stimuli produced weak gamma despite various stimulus optimizations and therefore showed a negligible effect of attention although the same participants showed robust gamma activity for full-screen gratings. Thus, alpha and SSVEP won over gamma in capturing attentional modulation in human EEG. This result was in contrast to the findings of a comparable study in monkeys, where gamma and alpha won over SSVEPs. This study highlights the effectiveness of various neural measures in studying visual spatial attention and further implicates their usefulness in decoding behavior and attentional state in humans.
DBT-Wellcome Trust India Alliance (Grant IA/S/18/2/504003), Tata Trusts, DBT-IISc Partnership Programme