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Raghuram, Hanumanthan, Rittik Deb, Diptarup Nandi, and Rohini Balakrishnan. "Silent katydid females are at higher risk of bat predation than acoustically signalling katydid males." Proceedings of the Royal Society B: Biological Sciences 282, no. 1798 (January 7, 2015): 20142319. http://dx.doi.org/10.1098/rspb.2014.2319.
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Males that produce conspicuous mate attraction signals are often at high risk of predation from eavesdropping predators. Females of such species typically search for signalling males and their higher motility may also place them at risk. The relative predation risk faced by males and females in the context of mate-finding using long-distance signals has rarely been investigated. In this study, we show, using a combination of diet analysis and behavioural experiments, that katydid females, who do not produce acoustic signals, are at higher risk of predation from a major bat predator, Megaderma spasma , than calling males. Female katydids were represented in much higher numbers than males in the culled remains beneath roosts of M. spasma . Playback experiments using katydid calls revealed that male calls were approached in only about one-third of the trials overall, whereas tethered, flying katydids were always approached and attacked. Our results question the idea that necessary costs of mate-finding, including risk of predation, are higher in signalling males than in searching females.
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Kusuminda, Tharaka, Amani Mannakkara, Rajika Gamage, Bruce D. Patterson, and Wipula B. Yapa. "Roosting ecology of insectivorous bats in a tropical agricultural landscape." Mammalia 86, no. 2 (November 29, 2021): 134–43. http://dx.doi.org/10.1515/mammalia-2021-0056.
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Abstract Bats spend more than half of their life in roosts, where key life events transpire. Therefore the availability and selection of roosts are important to bats everywhere, and may limit their ability to exploit every habitat, including agricultural landscapes such as paddy fields, orchards and tea plantations. This study aimed to investigate the day roosts used by insectivorous bat species in tea plantations of Sri Lanka. We surveyed 18 tea plantations where we recorded a total of 44 roosts involving five families and nine species of bats (Hipposideros galeritus, Hipposideros lankadiva, Hipposideros speoris, Rhinolophus beddomei, Rhinolophus rouxii, Megaderma spasma, Pipistrellus ceylonicus, Pipistrellus coromandra and Miniopterus cf. fuliginosus). Most (26) of the recorded roosts were geomorphic, (11) were anthropogenic, and (7) were in vegetation. H. lankadiva and M. cf. fuliginosus are the only species known to roost exclusively in geomorphic roosts; all others were opportunistic. Although protecting bat roosts is crucial for their conservation, it is challenging in view of existing tea management practices. Therefore, natural roosts should be maintained and protected. The introduction of artificial roosts might increase the number of bats able to forage over tea plantations and maximize their consumption of agricultural pests, thereby increasing tea production.
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Chandra, Mahua, Narayan Saha, Provat Kumar Sarkar, Most Samsun Nahar Sumi, Shyamal Sarker, Nazmul Haque, and Banita Mistry. "Response and Outcome of Moderate Dose Adrenocorticotropic Hormone in the Treatment of West Syndrome." Journal of National Institute of Neurosciences Bangladesh 7, no. 2 (February 6, 2022): 108–12. http://dx.doi.org/10.3329/jninb.v7i2.58096.
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Background: West Syndrome (WS) consist of a triad of epileptic spasms, hypsarrhythmia on EEG and arrest or regression of psychomotor development. Although ACTH has been found to be effective in the treatment of WS, questions remain regarding the optimum dosage, type of ACTH, duration of therapy, and its comparative efficacy with other treatment options.
Objective: To assess the response and outcome of treatment with moderate dose (100 IU/m2) ACTH in children of west syndrome.
Methodology: This was a prospective observational study and done over 1-year period (July 2017 to June 2018) in Pediatric Neurology OPD, National Institute of Neuroscience and Hospital (NINS&H), Dhaka among the patients with West syndrome. All study participants were treated with moderate dose ACTH (100 unit/m2) (I/M) and treatment completed within 12 weeks. Patients were followed up at 2, 4, 6 and 12 WKs of treatment.
Results: Total 52 cases were for enrolled. In this study it was found that complete cessation of spasm 21/50 (42%), ≥50% reduction of spasm 12/50 (24%), <50% reduction of spasm 8/50 (16%) and non-responder 9/50 (18%). At the end point of 12 weeks observation resolution of hypsarrhythmia occurred in 19/50 (38%) cases. About 78.0% patients developed any kind of the adverse effect.
Conclusion: Moderate dose ACTH is effective in cessation of spasm and resolution of hypsarrhythmia in the studied children.
Journal of National Institute of Neurosciences Bangladesh, July 2021, Vol. 7, No. 2, pp. 108-112
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Asanuma, Hideomi, Shuji Wakai, Tatsuya Tanaka, and Shunzo Chiba. "Brain tumors associated with infantile spasms." Pediatric Neurology 12, no. 4 (May 1995): 361–64. http://dx.doi.org/10.1016/0887-8994(95)00057-m.
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Santoso, Ari, and Eko Budi Prasetyo. "PENATALAKSANAAN FISIOTERAPI PADA KONDISI TRIGGER FINGER DENGAN INTERVENSI ULTRASOUND (US), INFRARED (IR) DAN TRANSVERSE FRICTION DI RSUD BENDAN PEKALONGAN." Jurnal Fisioterapi dan Rehabilitasi 2, no. 2 (July 16, 2018): 44–52. http://dx.doi.org/10.33660/jfrwhs.v2i2.22.
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Trigger finger or tenosyvitis stenosing is described as a condition wherethe finger tendon is locked at the time of movement from the flexion positiontoward the extension position. This is due to local inflammation or the presence ofswelling in the flexor tendon wrap that causes the wrapper can not normally flow.Signs and symptoms that arise is the presence of pain, the spasm M. FleksorDigitorum, decreased strength of M. Fleksor Digitorum, limitations of fingerjoints. Physiotherapy modalities used include: ultrasound, infra red and transversefriction.To know the benefits of therapy with ultrasound modality, infra red andtransverse friction in relieving pain, reducing spasm M. Flexor Digitorum,increasing muscle strength M. Flexor Digitorum, increasing the scope of fingerjoint motion. Management of physiotherapy on finger trigger conditions withultrasound, infrared, and transverse friction modalities.
After receiving physiotherapy treatment (ultrasound, infra red and transferfriction) for 6 times the therapy was obtained: 1) Decreased the tenderness of theflexor tendon from T1: 5.1 cm to T6: 0.9 cm, 2) Increased scope of joint motion inthe left PIP II of T1: S = 20º-0º-30º to T6: S = 28º-0º-60º and MCP II T1: S = 10º0º-30ºto T6:S=14º-0º-59º,3)Increased strength of M.Flexor Digitorum on PIP II Sinistra from T1: 4 to T6: 5, 4) Decreased the spasm of M. Fleksor Digitorum from T1: 1 to T6: 0. Ultasound, infra red and transverse friction can reduce pain,reduce spasm M. Flexor Digitorum, increase strength M. Flexor Digitorum,increase the scope of joint motion.
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Vetiani, Asmin, Wijianto Wijianto, and Arif Pristianto. "Program Fisioterapi Untuk Mengatasi Keluhan Pada Cervical Root Syndrome: Studi Kasus." Physiotherapy Health Science (PhysioHS) 4, no. 1 (August 9, 2022): 1–6. http://dx.doi.org/10.22219/physiohs.v4i1.21864.
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Cervical Root Syndrome (CRS) adalah suatu kondisi yang disebabkan oleh iritasi atau kompresi radikulopati serviks yang disebabkan oleh tonjolan diskus invertebralis dengan hilangnya sensorik atau motorik. Penelitian ini untuk mengetahui manfaat dari pemberian Transcutaneous Electrical Nerve Stimulation (TENS), Ultra Sound (US), Neck Calliet Exercise, Stretching, dan Cervical Traction pada kasus CRS. Pengukuran yang dipakai yaitu pengukuran nyeri menggunakan Numerical Rating Scale (NRS), pengukuran Lingkup Gerak Sendi (LGS) menggunakan meterline, dan pengukuran spasme otot dengan palpasi. Pengukuran kemampuan fungsional menggunakan Neck Disability Index (NDI). Penelitian dilakukan secara langsung kepada seorang pasien dengan kondisi CRS dengan pemberian terapi sebanyak enam kali pertemuan dengan pemberian intervensi fisioterapi. Setelah dilakukan intervensi tersebut didapatkan hasil bahwa terjadi penurunan nyeri pada nyeri gerak dan tekan. Terjadi peningkatan LGS pada bidang gerak leher fleksi, lateral fleksi dekstra dan sinistra, rotasi neck dekstra. Terjadi penurunan nilai spasme pada m. upper trapezius dekstra. Penurunan keluhan menyebabkan perbaikan pada kemampuan fungsional (NDI) dimana tingkatan intensitas nyeri, perawatan diri, aktivitas mengangkat, bekerja, dan tidur. Pemberian intervensi pada kasus CRS terdapat penurunan nyeri gerak dan nyeri tekan, peningkatan LGS, penurunan spasme otot m. upper trapezius, dan peningkatan kemampuan fungsional NDI.
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IKA RAHMAN and ANGGI AGUSTINI. "PENATALAKSANAAN FISIOTERAPI PADA KASUS BELL’S PALSY DEKSTRA DENGAN MODALITAS ELECTRICAL STIMULATION (FARADIK), MASSAGE DAN TERAPI LATIHAN." INFOKES (Informasi Kesehatan) 6, no. 2 (January 6, 2023): 16–33. http://dx.doi.org/10.56689/infokes.v6i2.920.
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Bell’s Palsy adalah kelemahan atau kelumpuhan saraf perifer wajah secara akut pada sisi sebelah wajah. Untuk mengetahui pelaksanaan Fisioterapi dalam meningkatkan kekuatan otot wajah, mengurangi rasa tebal pada sisi wajah yang lesi, merileksasikan otot wajah, memelihara sifat fisiologis otot, danmenggunakan modalitas Electrical Stimualtion arus Faradik, Massage dan Terapi latihan. Setelah dilakukan sebanyak 8 kali terapi didapat hasil penilaian peningkatan kekuatan otot M. Frontalis T1 : 1 menjadi T8 : 5, M. Orbicularis occuli T1 : 3 menjadi T8 : 5, M. Zygomaticus Mayor T1 : 1 menjadi T8 : 5, M. Orbicularis oris T1 : 1 menjadi T8 : 3, M. Procerus T1 : 1 Menjadi T8 : 3, M. Bucinator T1 : 1 menjadi T8 : 5, M. Depresor anguli oris T1 : 1 menjadi T8 : 3, M. Corrugator Supercilli T1 : 1 menjadi T8 : 5, M. Nasalis T1 : 1 menjadi T8 : 3, M. Sepresor labi inferior T1 : 1 menjadi T8 : 5, M. Mentalis T1 : 1 menjadi T8 : 5, M. Platysma T1 : 1 menjadi T8 : 5, peningkatan skala ugo fisch pada posisi istirahat T1 : 14 menjadi T8 : 20, mengerutkan dahi T1 : 3 menjadi T8 : 10, menutup mata T1 : 21 menjadi T8 : 30, tersenyum T1 : 9 menjadi T8 : 30, bersiul T1 : 3 menjadi T8 : 7. Electrical Stimulation arus Faradik dapat membantu meningkatkan kekuatan otot wajah, Massage dan Terapi Latihan dapat memelihara sifat fisiologis otot, mengurangi rasa tebal pada wajah, dan mencegah spasme pada sisi yang sehat.Kata kunci: Bell’s Palsy ,Electrical Stimulation arus Faradik, Massage dan Terapi Latihan. mencegah spasme pada sisi wajah yang sehat pada kasus Bells’s Palsy Dekstra dengan
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KARADURMUŞ, Leyla, Esen Bellur ATİCİ, and Sibel A. ÖZKAN. "ELECTROCHEMICAL INVESTIGATION OF OTILONIUM BROMIDE USING BORON-DOPED DIAMOND AND GLASSY CARBON ELECTRODES." Ankara Universitesi Eczacilik Fakultesi Dergisi 47, no. 3 (August 29, 2023): 30. http://dx.doi.org/10.33483/jfpau.1344014.
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Objective: Using cyclic (CV) and differential pulse (DPV) voltammetric techniques, the electrochemical research of otilonium bromide (OTB) was carried out over a wide pH range (0.3–12) at glassy carbon electrodes (GCE) and boron-doped diamond electrodes (BDDE). The typical electrochemical behavior of OTB was identified as being dependent on the type of working electrode and pH. This research aims to provide a brand-new electroanalytical technique for measuring OTB in buffer solutions. Material and Method: All experiments employed the typical three-electrode cell of 10 ml capacity in conjunction with a platinum wire counter electrode, a BDDE and GCE working electrode, and an Ag/AgCl reference electrode. NOVA 1.8 software and an AUTOLAB 204 potentiostat/galvanostat were used for electrochemical measurements. Result and Discussion: The electrochemical behavior of OTB, which belongs to a class of drugs called 'antispasmodics' (spasm and cramps reliever), primarily used to treat irritable bowel syndrome (IBS), and other gastrointestinal conditions characterized by motility problems, painful bowel spasms and distension (swelling and bloating in the belly area), was examined in 0.1 M H2SO4 at BDDE and GCE. The electrooxidation mechanism was also investigated by conducting CV investigations at various pH levels throughout a broad pH range (pH 0.3-12.0). Understanding the mechanism was aided by scan rate investigations, which revealed that diffusion was controlled for both electrodes. The proposed technique was successfully used to determine OTB under optimal conditions.
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Sacknoff, David M., James R. Wilentz, Mark B. Schiffer, Michael Bush, and Neil L. Coplan. "Exercise-induced ST-segment depression: Relationship to nonocclusive coronary artery spasm." American Heart Journal 125, no. 1 (January 1993): 242–44. http://dx.doi.org/10.1016/0002-8703(93)90084-m.
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Angerhausen, Daniel, Haley Sapers, Eugenio Simoncini, Stefanie Lutz, Marcelo da Rosa Alexandre, and Douglas Galante. "An Astrobiological Experiment to Explore the Habitability of Tidally Locked M-Dwarf Planets." Proceedings of the International Astronomical Union 8, S293 (August 2012): 192–96. http://dx.doi.org/10.1017/s1743921313012817.
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AbstractWe present a summary of a three-year academic research proposal drafted during the Sao Paulo Advanced School of Astrobiology (SPASA) to prepare for upcoming observations of tidally locked planets orbiting M-dwarf stars. The primary experimental goal of the suggested research is to expose extremophiles from analogue environments to a modified space simulation chamber reproducing the environmental parameters of a tidally locked planet in the habitable zone of a late-type star. Here we focus on a description of the astronomical analysis used to define the parameters for this climate simulation.
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Hasbiah, Hasbiah, and Nurul Fajriah. "PENATALAKSANAAN FISIOTERAPI PADA GANGGUAN FUNGSIONAL LUMBAL AKIBAT SPONDILOLISTESIS DI RSUP. Dr. WAHIDIN SUDIROHUSODO MAKASSAR." Media Fisioterapi Politeknik Kesehatan Makassar 11, no. 1 (May 30, 2019): 19. http://dx.doi.org/10.32382/mf.v11i1.818.
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Spondylosis lumbal merupakan gangguan degenerative yang terjadi pada corpus dan discus intervertebralis, yang ditandai dengan pertumbuhan osteofit pada corpus vertebra tepatnya pada tepi inferior dan superior corpus. Dari temuan radiografik 13% pada pria usia 30-an, dan 100% pada pria usia 70-an. Sedangkan pada wanita umur 40-an 5% dan umur 70-an 96%. Penyebabnya yaitu faktor usia, jenis kelamin, pekerjaan dan obesitas. Gejala yang sering muncul yaitu nyeri, spasme otot. Penelitian ini merupaka case study dengan menggunakan sampel tunggal untuk mengetahui perubahan nyeri dan spasme otot setelah diberikan intervensi Micro Wave Diathermy (MWD) dan terapi latihan William Flexion Exercise . alat ukur yang digunakan adalah VAS. Penelitian ini dilakukan di RSUP. Dr. Wahidin Sudirohusodo. Pada kajian kasus ini, hasil pemeriksaan ditemukan problematik yaitu adanya nyeri dan spasme otot m. Erector spine. Penatalaksanaa fisioterapi dengan menggunakan MWD dan William Flexion Exercise mengalami penurunan nyeri mulai dari pre test minggu I sebesar 6,5 sampai terapi minggu ke 4 turun menjadi 4,5, pada nyeri tekan juga terjadi penurunan nyeri mulai dari pre test minggu I sebesar 7 sampai pada terapi minggu ke IV turun menjadi 5. Kata kunci : Spondylosis lumbal, Micro Wave Diathermy (MWD), William Flexion Exercise
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Wilkinson, Marshall F., Tumul Chowdhury, W. Alan Mutch, and Anthony M. Kaufmann. "Analysis of facial motor evoked potentials for assessing a central mechanism in hemifacial spasm." Journal of Neurosurgery 126, no. 2 (February 2017): 379–85. http://dx.doi.org/10.3171/2016.2.jns151384.
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OBJECTIVE Hemifacial spasm (HFS) is a cranial nerve hyperactivity disorder characterized by unique neurophysiological features, although the underlying pathophysiology remains disputed. In this study, the authors compared the effects of desflurane on facial motor evoked potentials (MEPs) from the spasm and nonspasm sides of patients who were undergoing microvascular decompression (MVD) surgery to test the hypothesis that HFS is associated with a central elevation of facial motor neuron excitability. METHODS Facial MEPs were elicited in 31 patients who were undergoing MVD for HFS and were administered total intravenous anesthesia (TIVA) with or without additional desflurane, an inhaled anesthetic known to centrally suppress MEPs. All measurements were completed before dural opening while a consistent mean arterial blood pressure was maintained and electroencephalography was performed. The activation threshold voltage and mean amplitudes of the MEPs from both sides of the face were compared. RESULTS There was a significantly lower mean activation threshold of facial MEPs on the spasm side than on the nonspasm side (mean ± SD 162.9 ± 10.1 vs 198.3 ± 10.1 V, respectively; p = 0.01). In addition, MEPs were also elicited more readily when single-pulse transcranial electrical stimulation was used on the spasm side (74% vs 31%, respectively; p = 0.03). Although desflurane (1 minimum alveolar concentration) suppressed facial MEPs on both sides, the suppressive effects of desflurane were less on the spasm side than on the nonspasm side (59% vs 79%, respectively; p = 0.03), and M waves recorded from the mentalis muscle remained unchanged, which indicates that desflurane did not affect the peripheral facial nerve or neuromuscular junction. CONCLUSIONS Centrally acting inhaled anesthetic agents can suppress facial MEPs and therefore might interfere with intraoperative monitoring. The elevated motor neuron excitability and differential effects of desflurane between the spasm and nonspasm sides support a mechanism of central pathophysiology in HFS. Clinical trial registration no.: B2012:099 (clinicaltrials.gov)
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Yulianasari, Hertina, and Nur Susanti. "PENATALAKSANAAN FISIOTERAPI PADA KONDISI ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) DENGAN METODE NEURO SENSO MOTOR REFLEX DEVELOPMENT DAN PLAY THERAPYDI YPAC SURAKARTA." Pena Jurnal Ilmu Pengetahuan dan Teknologi 33, no. 1 (March 27, 2019): 44. http://dx.doi.org/10.31941/jurnalpena.v33i1.841.
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<p>Attention Deficit Hyperactivity Disorder (ADHD) is a behavioral disorder characterized by concentration disorders and impaired concentration, and delayed speech in patients. Factors influencing the occurrence of ADHD are factors prenatal and postnatal prenatal complications, and environmental factors. Problematic on ADHD condition of postural hypotonus, spasm in M. Extensor Trunk, M. Trapesiuz Upper and M. Gastrocnemius, presence of postural hypotonus, sensory impairment with sensory blast, behavioral disorder, presence of reflux, Presence of functional activity disorder.</p><p>Physiotherapy modalities that used under ADHD conditions are by administering <em>Neuro</em><em>Senso Motor Reflex Development &Syncronization</em> modalities and play therapy. In this research use descriptive analytic method, and research design used is case study design. After 6 treatments (1)There is a change of postural tone from sitting 2 seconds to 15 seconds, standing 5 seconds to 10 seconds. (2) there was a decrease of spasm in M. Extensor Trunk, M. Trapesiuz Upper and M. Gastrocnemius on T4-T6. (3) There is a change in sensory examination of visual, auditory, tactile, touch, vestibular, and propioceptive on T4-T6. (4) There is a change in the examination of moro reflex, graps, stnr toward extension and extensor thrust on T4-T6. (5) There is a change in the examination of ADHD Test on T6.</p>From the results obtained can be concluded that using the intervention of physiotherapy with NeuroSenso<em> Motor Reflex Development &Syncronization</em>modality and play therapy can help reduce the problems that arise in Attention Deficit Hyperactyvity Disorder (ADHD).
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Fakhrurrizal, Richan, Sahala Hutabarat, and Agus Hartoko. "ANALISA SEBARAN SPASIAL IKAN CUCUT (Ordo Rajiformes) BERDASARKAN VARIASI KEDALAMAN DI PERAIRAN LAUT JAWA." Management of Aquatic Resources Journal (MAQUARES) 3, no. 1 (January 29, 2014): 71–80. http://dx.doi.org/10.14710/marj.v3i1.4288.
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Ikan cucut atau hiu termasuk dalam kategori ikan-ikan bertulang rawan (elasmobranchii). Cucut merupakan ikan demersal sehingga perlu diketahui kedalaman suatu perairan untuk mengetahui habitatnya. Kedalaman tersebut dapat diketahui dengan menggunakan penginderaan jauh. Penginderaan jauh merupakan suatu cara pengamatan objek tanpa menyentuh objek secara langsung. Tujuan penelitian adalah mengetahui perkembangan hasil tangkapan cucut, sebaran kedalaman di laut Jawa, dan hubungan antara sebaran kedalaman dengan hasil tangkapan cucut. Metode yang digunakan dalam penelitian ini adalah metode eksploratif. Pengambilan data menggunakan metode purposive sampling. Pertimbangan pengambilan data didasarkan pada hasil wawancara dengan nelayan setempat dan ketersediaan data produksi hasil tangkapan cucut yang dilengkapi titik koordinat lokasi penangkapan dari PPN Kejawanan pada tahun 2011 – 2012 adalah yang paling memadai, serta dilakukan pula analisa kedalaman yang berasal dari data batimetri laut Jawa. Analisis data yang digunakan adalah analisis korelasi antara kedalaman dengan hasil tangkapan cucut untuk mengetahui hubungan sebaran spasial ikan cucut dengan variasi kedalaman, didukung dengan studi pustaka tentang habitat ikan cucut. Hasil dari penelitian ini menunjukkan bahwa hasil tangkapan Cucut Junjunan (Rhynchobatus djiddensis) tertinggi didapatkan pada musim barat tahun 2011 dengan total hasil tangkapan 7440 kg, sedangkan tangkapan Cucut Depo (Rhinobatos schegelii) tertinggi didapatkan pada musim timur tahun 2011 dengan total hasil tangkapan 7383 kg. Variasi kedalaman di laut Jawa yang menunjukkan daerah penangkapan cucut pada musim timur berkisar antara 11 – 167 m, dengan kedalaman rata-rata 80 m pada daerah penangkapan cucut Depo. Kedalaman pada musim barat berkisar antara 14 – 134 m, dengan kedalaman rata-rata 50 m pada daerah penangkapan cucut Junjunan. Secara umum nilai koefisien korelasi (r) setiap jenis cucut yang didapat pada musim timur maupun musim barat adalah ≤ 0,5. Hal ini menunjukkan bahwa hubungannya rendah (tidak erat) yang berarti terdapat sedikit pengaruh kedalaman terhadap hasil tangkapan cucut di laut Jawa.
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Hellstrom, H. R. "Evidence in support of the spasm of resistance vessel concept of ischemic heart disease: An update in 1993." Medical Hypotheses 41, no. 1 (July 1993): 11–22. http://dx.doi.org/10.1016/0306-9877(93)90026-m.
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Fibriani, Indah Ayu, and Eko Budi Prasetyo. "PENATALAKSANAAN FISIOTERAPI PADA KONDISI LOW BACK PAIN et CAUSA SPONDYLOSIS LUMBAL DENGAN MODALITAS ULTRASOUND, TRANSCUTANEUS ELECTRICAL NERVE STIMULATION DAN WILLIAM’S FLEXION EXERCISE DI RSUD KRATON PEKALONGAN." Jurnal Fisioterapi dan Rehabilitasi 2, no. 2 (July 16, 2018): 104–14. http://dx.doi.org/10.33660/jfrwhs.v2i2.26.
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Low Back Pain et causa Spondylosis Lumbar is a degenerative process that occurs in the corpus and the intervertebral disc due to a decrease in the density ofthe corpus intervertebra and narrowing of the corpus intervertebral causedthinning of the disc, along with lower back pain due to stress back muscles,tendons, ligaments with symptoms such as Local pain not accompanied bytingling, weakness or neurological disorders. Problems of physiotherapy includepain silent press and motion in the lower back spasm, decreased trunk musclestrength, range of motion limitations trunk, decreased functional activity. In thiscase the selected intervention technologies to overcome the above problems byusing ultrasound modality, transcutaneus electrical nerve stimulation andWilliam's flexi exercise. Design research with descriptive method used in thepreparation of scientific papers is a case study. The taking of scientific papers isdone in RSUD Kraton Pekalongan. Based therapy that has been done obtained the following results: (1)decrease in silent pain becomes T6 T1 = 8 = 2, the tenderness T1 = 2 to T6 = 1,and the motion pain becomes T1 = 4.8 T6 = 1, (2) a decrease in muscle spasm atT1 = spasm, at T6 = spasm but decreases, (3) an increase in muscle strength m.Flexor trunk T1 = 2 to T6 = 3, at m. extensor trunk T1 = 2 to T6 = 3, (4) anincrease in the scope of flexion trunk T1 = 4 to T6 = 6, the extension trunk T1 = 4to T6 = 6, lateral dextra trunk T1 = 3 to T6 = 8, lateral sinistra Trunk T1 = 8 to T6= 9 (5) an increase in functional activity T1 = 18% to T6 = 2%. With the results obtained it can be concluded that the use of the modalitiesof physiotherapy with ultrasound, transcutaneus electrical nerve stimulation andWilliam's flexi physiotherapy exercise can help the problems arising from lowback pain lumbar spondylosis et causa.
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Vaney, C., M. Heinzel-Gutenbrunner, P. Jobin, F. Tschopp, B. Gattlen, U. Hagen, M. Schnelle, and M. Reif. "Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study." Multiple Sclerosis Journal 10, no. 4 (August 2004): 417–24. http://dx.doi.org/10.1191/1352458504ms1048oa.
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Objective: Cannabis may alleviate some symptoms associated with multiple sclerosis (MS). This study investigated the effect of an orally administered standardized Cannabis sativa plant extract in MS patients with poorly controlled spasticity. Methods: During their inpatient rehabilitation programme, 57 patients were enrolled in a prospective, randomized, double-blind, placebo-controlled crossover study of cannabis-extract capsules standardized to 2.5 mg tetrahydrocannabinol (THC) and 0.9 mg cannabidiol (CBD) each. Patients in group A started with a drug escalation phase from 15 to maximally 30 mg THC by 5 mg per day if well tolerated, being on active medication for 14 days before starting placebo. Patients in group B started with placebo for seven days, crossed to the active period (14 days) and closed with a three-day placebo period (active drug dose escalation and placebo sham escalation as in group A). Measures used included daily self-report of spasm frequency and symptoms, Ashworth Scale, Rivermead Mobility Index, 10-m timed walk, nine-hole peg test, paced auditory serial addition test (PASAT), and the digit span test. Results: In the 50 patients included into the intention-to-treat analysis set, there were no statistically significant differences associated with active treatment compared to placebo, but trends in favour of active treatment were seen for spasm frequency, mobility and getting to sleep. In the 37 patients (per-protocol set) who received at least 90% of their prescribed dose, improvements in spasm frequency (P- 0.013) and mobility after excluding a patient who fell and stopped walking were seen (P- 0.01). Minor adverse events were slightly more frequent and severe during active treatment, and toxicity symptoms, which were generally mild, were more pronounced in the active phase. Conclusion: A standardized Cannabis sativa plant extract might lower spasm frequency and increase mobility with tolerable side effects in MS patients with persistent spasticity not responding to other drugs.
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Shakurova, D. A., and Kh A. Alimetov. "Birth injury to the cervical spine as a cause of acute ethmoiditis in children." Kazan medical journal 100, no. 3 (June 13, 2019): 516–23. http://dx.doi.org/10.17816/kmj2019-516.
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Aim. Improvement of the efficacy of diagnosis of spondylogenic ethmoiditis in children.
Methods. The study sample included 82 children aged 3 to 10 years: 39 (47.6) boys and 43 (52.4) girls. Patients were divided into three groups. Group 1 included 20 patients with acute ethmoiditis; group 2 included 31 patients with other diseases of ENT-organs; group 3 included 31 relatively healthy children. Apart from physical examination performed by an otorhinolaryngologist, pediatrician, neurologist and other specialists, and X-ray of paranasal sinuses including contrast radiography, the investigation plan included facial electromyography in ethmoid sinus projection area.
Results. Electromyographic parameters in relatively healthy children corresponded to the reference while in patients with acute ethmoiditis muscle tone in ethmoid sinus projection area was increased and amplitude of contractions was decreased, which was caused by muscle spasm. Increased latency of M response was revealed compared to the norm on both sides. In the group of patients with other diseases of ENT organs the following results were obtained: muscle tone in ethmoid sinus projection area was increased as well as in group 2, contraction amplitude was decreased that is a result of spasm and muscle tension. M response latency exceeded normal value only on one side where the most severe inflammatory process was observed.
Conclusion. To confirm the relationship between congenital pathology of the cervical spine and inflammatory process in nasal cavity and cells of ethmoid labyrinth, electromyography is warranted.
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Kaida, Tomoko, Takashi Ono, Tadatoshi Tokunaga, Keita Takada, Shota Tokuda, Naoto Kuwabara, Takushi Kawamorita, Kazutaka Kamiya, Nobuyuki Shoji, and Kazunori Miyata. "Prevalence of Accommodative Microfluctuations in Eyes after Cataract Surgery." Journal of Clinical Medicine 12, no. 15 (August 5, 2023): 5135. http://dx.doi.org/10.3390/jcm12155135.
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Background: We aimed to evaluate the existence of accommodative microfluctuations in eyes after cataract surgery. Methods: This retrospective observational cohort study included 1160 eyes of 713 patients (mean age: 72.5 ± 8.3 years) who underwent phacoemulsification, intraocular lens insertion, and an evaluation of accommodative microfluctuations with an autorefractometer. Patients with posterior segment disorders resulting in visual acuity impairment and those with unavailable medical information were excluded. High-frequency components (HFCs), between 1.0–2.3 Hz, based on fast Fourier transform analysis of the accommodative microfluctuation data were examined at postoperative 2–3 (2 M) and 6 months (6 M). The relationships between the HFCs and patient age, manifest refraction, and axial length were analyzed. Results: Increased HFC values (>65) were observed at a constant rate after cataract surgery, with prevalence rates of 33.4% at 2 M and 34.7% at 6 M. Postoperatively, at 2 M, increased HFC values were significantly more common for eyes with axial length ≥26 mm than for those with axial length <26 mm (p = 0.0056). However, they were not significantly correlated to age or postoperative manifest refraction. Conclusions: At 2 M postoperatively, increased HFC values presented more frequently in eyes with a greater axial length; hence, the precise detection and understanding of postoperative accommodative spasms in high myopia patients is important.
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Wray, Carter D., Marisa W. Friederich, Desiree du Sart, Sarah Pantaleo, Joél Smet, Cathlin Kucera, Laura Fenton, Gunter Scharer, Rudy Van Coster, and Johan L. K. Van Hove. "A new mutation in MT-ND1 m.3928G>C p.V208L causes Leigh disease with infantile spasms." Mitochondrion 13, no. 6 (November 2013): 656–61. http://dx.doi.org/10.1016/j.mito.2013.09.004.
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Hooke, Amber L., Lee Allen, and Luke K. P. Leung. "Clinical signs and duration of cyanide toxicosis delivered by the M-44 ejector in wild dogs." Wildlife Research 33, no. 3 (2006): 181. http://dx.doi.org/10.1071/wr05020.
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Sodium cyanide poison is potentially a more humane method to control wild dogs than sodium fluoroacetate (1080) poison. This study quantified the clinical signs and duration of cyanide toxicosis delivered by the M-44 ejector. The device delivered a nominal 0.88 g of sodium cyanide, which caused the animal to loose the menace reflex in a mean of 43 s, and the animal was assumed to have undergone cerebral hypoxia after the last visible breath. The mean time to cerebral hypoxia was 156 s for a vertical pull and 434 s for a side pull. The difference was possibly because some cyanide may be lost in a side pull. There were three distinct phases of cyanide toxicosis: the initial phase was characterised by head shaking, panting and salivation; the immobilisation phase by incontinence, ataxia and loss of the righting reflex; and the cerebral hypoxia phase by a tetanic seizure. Clinical signs that were exhibited in more than one phase of cyanide toxicosis included retching, agonal breathing, vocalisation, vomiting, altered levels of ocular reflex, leg paddling, tonic muscular spasms, respiratory distress and muscle fasciculations of the muzzle.
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Fix, Isabelle, Lorenz Heidinger, Thorsten Friedrich, and Gunhild Layer. "The Radical SAM Heme Synthase AhbD from Methanosarcina barkeri Contains Two Auxiliary [4Fe-4S] Clusters." Biomolecules 13, no. 8 (August 18, 2023): 1268. http://dx.doi.org/10.3390/biom13081268.
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In archaea and sulfate-reducing bacteria, heme is synthesized via the siroheme-dependent pathway. The last step of this route is catalyzed by the Radical SAM enzyme AhbD and consists of the conversion of iron-coproporphyrin III into heme. AhbD belongs to the subfamily of Radical SAM enzymes containing a SPASM/Twitch domain carrying either one or two auxiliary iron–sulfur clusters in addition to the characteristic Radical SAM cluster. In previous studies, AhbD was reported to contain one auxiliary [4Fe-4S] cluster. In this study, the amino acid sequence motifs containing conserved cysteine residues in AhbD proteins from different archaea and sulfate-reducing bacteria were reanalyzed. Amino acid sequence alignments and computational structural models of AhbD suggested that a subset of AhbD proteins possesses the full SPASM motif and might contain two auxiliary iron–sulfur clusters (AuxI and AuxII). Therefore, the cluster content of AhbD from Methanosarcina barkeri was studied using enzyme variants lacking individual clusters. The purified enzymes were analyzed using UV/Visible absorption and EPR spectroscopy as well as iron/sulfide determinations showing that AhbD from M. barkeri contains two auxiliary [4Fe-4S] clusters. Heme synthase activity assays suggested that the AuxI cluster might be involved in binding the reaction intermediate and both clusters potentially participate in electron transfer.
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Putra, Andikha, and Harnavi Harun. "Gitelman Syndrome in a 32-Years-Old Female Patient." Bioscientia Medicina : Journal of Biomedicine and Translational Research 6, no. 3 (January 19, 2022): 1485–89. http://dx.doi.org/10.37275/bsm.v6i3.464.
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Introduction. Gitelman syndrome is an autosomal recessive disorder that is milder than Bartter syndrome and is often not diagnosed until late childhood or even adulthood. However, this syndrome is usually symptomatic and can result in serious clinical manifestations, such as muscle spasms that can be severe and involve the hands and feet. These symptoms are frequently observed in almost all patients, partly due to hypokalemia and hypomagnesemia.
Case presentation. A 32-year-old female patient is being treated in the Internal Medicine ward of Dr. M. Djamil Padang General Hospital with the main complaint of cramping of the left hand, which has gotten worse since 1 day ago. The patient also complained that both legs were prone to cramping that went on and on since 1 month ago. The patient had been hospitalized with the same complaint and is currently taking slow release potassium (KSR) medication. Examination of the patient's limbs revealed a positive trousseau sign and carpopedal spasms. Laboratory examination of the patient showed potassium levels of 1.8 mmol/L, calcium levels of 5.7 mg/dl, Magnesium levels of 0.8 mg/dl, and electrolyte disturbances in the patient's urine. ECG results revealed a prolonged QT interval.
Conclusion. Gitelman syndrome is an autosomal recessive disorder and often goes undiagnosed. However, this syndrome is usually symptomatic and can lead to serious clinical manifestations. Most patients require oral potassium and magnesium supplementation, as drug therapy is usually not fully effective.
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Prasoppokakorn, Thaninee. "Acupuncture-Associated Mycobacterium massiliense and Scedosporium Infections Superimposed by Tetanus." Case Reports in Infectious Diseases 2022 (July 7, 2022): 1–4. http://dx.doi.org/10.1155/2022/8918020.
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Background. Tetanus has rarely been reported in Thailand since 1982 due to 100% tetanus vaccination coverage during the neonatal period of life. However, the reemergence of tetanus has been observed in our country during the past decade, mainly due to the increasing number of migrants traveling from neighboring countries in search of work. Acupuncture has become an essential part of alternative and complementary medicine. To our knowledge, acupuncture-associated Mycobacterium abscessus and Scedosporium infections superimposed by tetanus have never been reported. Case Presentation. A 55-year-old Thai female with schizophrenia was hospitalized due to a 4-day course of trismus, dysphagia, and back muscle spasms. Upon admission, a clinical diagnosis of tetanus was made, which included muscle rigidity and reflex muscle spasms, despite a recent history of diphtheria-tetanus (dT) vaccination for tetanus prophylaxis after 2 episodes of falling complicated by two lacerations on the left shoulder and head. Endotracheal intubation for airway protection was given, in addition to tetanus immunoglobulin, metronidazole, and diazepam which were prescribed to the patient. Incision and drainage of the wound on the left shoulder yielded 40 mL of pus, which subsequently grew Clostridium species, Mycobacterium massiliense, and Scedosporium on anaerobic bacterial, mycobacterial, and fungal cultures, respectively. An incision of an acupuncture wound on the abdominal wall yielded 1 mL of pus, which exhibited positive acid-fast bacilli (AFB) on AFB stain. Mycobacterial culture finally grew M. massiliense. The organism was susceptible to amikacin and clarithromycin. Amikacin, clarithromycin, ciprofloxacin, and voriconazole were then added. The patient gradually improved and was discharged after one month of hospitalization. The patient was reported to be doing well, with no neurological sequelae, when last seen one month after discharge. Conclusions. To our knowledge, this is the first case of acupuncture-associated M. massiliense and Scedosporium infections superimposed by tetanus. In Thailand, the occurrence of acupuncture by nonqualified individuals and the reemergence of tetanus remain prevalent. Hence, it is not uncommon to see tetanus in association with acupuncture-related nontuberculous mycobacterial/fungal infection.
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Meynier, Alexandra, Jeanine Lherminier, Joelle Demaison-Meloche, Christian Ginies, Andre Grandgirard, and Luc Demaison. "Effects of dietary oxysterols on coronary arteries in hyperlipidaemic hamsters." British Journal of Nutrition 87, no. 5 (May 2002): 447–58. http://dx.doi.org/10.1079/bjn2002555.
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The aim of this study was to evaluate the effect of dietary oxysterols on coronary atherosclerosis and vasospasm. Golden Syrian hamsters were fed three diets with different lipid contents for 3 months: (1) a normolipidaemic diet containing 25 g corn oil–fish oil (4:1, w/w)/kg (group Low L); (2) a hyperlipidaemic diet composed of the normolipidaemic diet supplemented with 150 g lard+30 g cholesterol/kg (group High L); (3) a third diet, similar to the hyperlipidaemic diet, in which 4 g cholesterol/kg was replaced by a mixture of oxysterols (group High L+OS). The oxysterol mixture contained (g/kg): 5,6α-epoxycholesterol 211, 5,6β-epoxycholesterol 179, 7α-hydroxycholesterol 67, 7β-hydroxycholesterol (7βOH) 185, 7-ketocholesterol (7 K) 235; and trace amounts of 7-hydroperoxycholesterols (approximately 30 g/kg). Atherosclerosis was evaluated by measuring myocardial Ca, oxysterols and acyl-CoA cholesterol acyl transferase (ACAT) activity; furthermore, coronary reactivity to sodium nitroprusside (5×10-6 m) was measured and the morphology of coronary arteries was visualized by transmission electron microscopy. Coronary spasm was determined by evaluating reactivity to serotonin (5×10-6 m). Feeding the high-lipid diet (group High L) increased the plasma level of 7βOH, 7 K and cholestanetriol. The presence of oxysterols in the diet (group High L+OS) further increased the concentrations of 7βOH and 7 K in the plasma. However, as evidenced by myocardial Ca, ACAT activity and coronary reactivity to sodium nitroprusside, severe atherosclerosis did not develop during the 3-month diet. 7 K was increased in myocardial lipids of groups High L and High L+OS. Electron microscopy did not show the development of atherosclerosis in group High L, whereas vascular wall thickening, endothelial damage and smooth muscle cell proliferation and migration occurred when oxysterols were present in the food. Serotonin (5×10-6 m) induced exacerbated coronary vasoconstriction in group High L that was completely reversed by dietary oxysterols. In conclusion, dietary oxysterols exhibit anti-spasmodic properties, but they cannot be used as agents against excess dietary lipid-induced coronary spasm because of their atherogenic properties.
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Tanaka, Yuichiro, and Shigetoshi Chiba. "Potentiating effects of extraluminal oxyhemoglobin to intraluminal 5-hydroxytryptamine in isolated canine internal carotid arteries." Journal of Neurosurgery 69, no. 2 (August 1988): 263–68. http://dx.doi.org/10.3171/jns.1988.69.2.0263.
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✓ The interaction between oxyhemoglobin (oxyHb) and 5-hydroxytryptamine (5-HT) was investigated in an experimental model of isolated canine internal and common carotid arteries with insertion of stainless steel cannulae. Extraluminal application of 10−5 M oxyHb induced marked and long-lasting vasoconstriction in the internal carotid but not in the common carotid arteries. The 5-HT-induced vasoconstriction was potentiated significantly in both the internal and common carotid arteries. These potentiations were not influenced by the presence or absence of endothelium, a finding which was confirmed by vascular responses to intraluminal acetylcholine. It is concluded that the interaction between extraluminal oxyHb and intraluminal 5-HT may be one of the possible etiological factors behind the chronic phase of vascular spasm following subarachnoid hemorrhage.
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Becheva, Maria. "Kinesitheraphy in trimalleolar fracture – case report." Pharmacia 67, no. 2 (July 31, 2020): 101–3. http://dx.doi.org/10.3897/pharmacia.67.e39045.
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The purpose of the paper is to prove the efficacy of a kinesitherapeutic program intherecovery of a patient with trimalleolar fractureofthe left lower limb.We present a 42-year-old patient with a trimalleolar fracture and paresis of n. peroneus communis. Kinesitherapy was performed after thirteen weeks of surgery for ten consecutive days. The kinesitherapeuticmeans included: cryotherapy, lymphatic drainage massage, isometric contractions for the femur muscles, active exercises with and without resistance, active exercises with and on gymnastic apparatuses, post-isometric relaxation for the sciatic musculature and m. triceps surai, training in walking.As a result of the kinesitherapeutic exercises, the ankle swelling decreased.The volume of movement increased, pain was reduced as well as the muscle spasm in the ankle joint. The gait improved.
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Serikov, К. V., L. М. Smirnova, G. А. Shifrin, and V. I. Dariy. "Integrative monitoring of systemic hemodynamics and the oxygen-transport status and the choice of the intensive therapy tactics in patients, suffering an ischemic cerebral insult." Klinicheskaia khirurgiia 86, no. 6 (June 27, 2019): 19–24. http://dx.doi.org/10.26779/2522-1396.2019.06.19.
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Objective. To elaborate the intensive therapy tactic in patients, suffering ischemic cerebral insult (ICI) depending on changes in the systemic hemodynamics indices and the oxygen-transportation status.Маterials and methods. In 42 patients, suffering the ICI of middle severity, ageing 45 - 88 years old, the integrative monitoring of the neurological state severity, systemic hemodynamics indices and the oxygen-transportation status on background of targeted intensive therapy was conducted.
Results. In the patients, suffering initial hypoxemia, a hypokinetic heart index (HI) - (2,0±0,1) l×min-1×m-2 and the lowered systemic delivery of oxygen (DO2) - (356±21) ml×min-1×m-2were revealed. Prophylactic oxygenation is needed if the value of the oxygen content in arterial blood (SаO2) exceeds 95% and DO2 is lesser than 520 ml×min-1×m-2. Aiming the achievement of eukinetic values of the HI, correction of vascular spasm and antihypertensive therapy was conducted, using alpha-adrenoblocking agent (urapydil) up to stabilization of the DO2 indices on the level of 520-600 ml×min-1×m-2. In hyperoxidal state a hyperkinetic HI - (3.6±0.1) l×min-1×m-2 and a raised DO2 - (699±14) ml×min-1×m-2 were revealed. Prophylactic oxygenation is not indicated if the value of the SаO2 index exceeds 95% and DO2 exceeds 600 ml×min-1×m-2. Aiming to achieve eukinetic values of HI it is mandatory to conduct antihypertensive therapy, using therapy with аlpha-beta-аdrenoblocking agent (labetalol).
Conclusion. Targeted intensive therapy, oriented towards balance with general oxygenation of the organism tissues, normalizes the oxygen-transport homeostasis in shortest terms, what impacts the results of treatment in patients, suffering ICI, immediately.
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Kakushkin, N. "M. Kalmykov. - A case of incorrect births with twins. - (Protocol. General Donskikh doctors for 1894, the tenth year, Novocherkassk, 1895. Appendices, p. 84)." Journal of obstetrics and women's diseases 9, no. 9 (December 23, 2020): 813–14. http://dx.doi.org/10.17816/jowd99813-814.
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The patient's first child (8-raga, 42 years old), gave birth safely. Then the attempts stopped. The patient, with the umbilical cord sticking out of the vagina, was engaged in the usual chores around the house. Only on the 4th day after the birth of the first child, the author saw the patient and, stating the presence of a living fetus in the uterus, burst the bubble. Despite the contractions, the presenting part, the buttocks, did not drop. Then the author undertook a manual extraction of the fetus, but met a strong obstacle in the release of the legs thrown upward: there was a spasm of the upper and middle sections of the uterus. All the same it was possible to free the legs. Extracted live fruit; squeezed out 2 small separate after. The author attaches to the article, not devoid of interest, a description of the situation in which he has to work as an obstetrician.
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Sinaga, Erikson, Nahitma Ginting, and Edy Suwarso. "Uji Aktivitas Antikejang Ekstrak Etanol Daun Titanus (Leea Aequata L.) Terhadap Ileum Marmut Terpisah (Cavia Porcellus) Secara In Vitro." Talenta Conference Series: Tropical Medicine (TM) 1, no. 1 (October 2, 2018): 320–30. http://dx.doi.org/10.32734/tm.v1i1.66.
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Titanus (Leea aequata L.) merupakan tumbuhan dari suku leeaceae yang digunakan dalam pengobatan tradisional di daerah Tanah Karo, Provinsi Sumatera utara, sebagai obat luka dan obat anti tetanus. Salah satu tanda utama dari penyakit tetanus adalah spasme otot atau kejang disebagian atau seluruh tubuh. Penelitian ini bertujuan untuk mengetahui efek antikejang berupa relaksasi dari ekstrak etanol daun titanus terhadap kontraksi ileum marmut terisolasi yang dikontrasikan dengan asetilkolin. Penelitian ini dilakukan secara in vitro menggunakan alat organ bath. Tahapan penelitian adalah persiapan bahan dan pengujian efek relaksasi ileum terpisah. Parameter yang diukur dalam penelitian ini adalah relaksasi otot polos ileum terpisah. Sebelum dilakukan pengujian, ileum marmut terpisah diekuilibrasi selama 45 menit sampai diperoleh kondisi yang stabil didalam larutan tyrode dengan suhu 37o C yang diaerasi dengan gas karbogen (O2:CO2) 95% : 5%. Pengujian efek relaksasi dilakukan setelah ileum marmut dikontraksi dengan asetilkolin, kemudian masing masing ileum diberikan konsentrasi kumulatif ekstrak daun titanus dan atropin sulfat . Hasil pengujian yang diperoleh menunjukkan bahwa pemberian ekstrak etanol daun titanus memiliki efek relaksasi. Ekstrak etanol daun titanus pada konsentrasi 2,5mg/ml (105,4203±2,9151) mempunyai kemampuan yang tidak berbeda dengan atropin sulfat 1 x 10-5 (113,9796±4,5825) dalam menurunkan kontraksi otot polos ileum yang diinduksi oleh asetilkolin 1,889 x 10-4 M (p>0,005). Jadi dapat disimpulkan bahwa ekstrak etanol daun titanus mempunyai efek relaksasi terhadap otot polos ileum terpisah dengan kemampuan yang tidak jauh berbeda dengan atropin sulfat.
Titanus (Leeaaequata L.) is a plant from Leeaceae family used in traditional medication in Tanah Karo, North Sumatera as wound and anti-tetanus medicine. One of the main signs of tetanus is muscle spasm or seizure in some or all parts of body. This research aimed to evaluatethe anti-seizure effect of titanus leaves ethanol extractsuch as relaxation isolated ileum of marmot which was contacted with acetylcholine. This research was conducted byin vitro studyusing organ bath instrument. The stages of this research were the material preparation and isolated ileum relaxation effect evaluation. The parameter measured in this research was the isolated ileum smooth muscle relaxation. Before the test, isolated marmot ileum was equilibrated for 45 minutes until the stable condition in tyrode solution was obtained at 37°C temperature which aerated with carbogen gas (O2:CO2) 95%:5%. The relaxation effect test was conducted aftermarmot ileum was contracted with acetylcholine, and then, titanus leaves extract and atropine sulfate were added to each ileumswith cumulative concentration. The result indicated that the titanus leaves ethanol extract had relaxation effect. Titanus Leaves ethanol extract in 2.5 mg/ml concentration (105.4203±2.9151) had the same ability as atropine sulfate 1x10-5 (113.9796±4.5825)in decreasing the ileum smooth muscle contraction induced with acetylcholine 1.889x10-4 M (p>0.005).It could be concluded that titanus leaves ethanol extract hasrelaxation effect to isolated ileum smooth muscle and it was not so different with atropine sulfate.
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Marks, CA, F. Gigliotti, F. Busana, M. Johnston, and M. Lindeman. "Fox control using a para-aminopropiophenone formulation with the M-44 ejector." Animal Welfare 13, no. 4 (November 2004): 401–7. http://dx.doi.org/10.1017/s0962728600028657.
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AbstractThe M-44 ejector (‘ejector‘) has proven to be a highly target-specific means of delivering toxicants to the exotic European red fox (Vulpes vulpes) in south-eastern Australia. Para-aminopropiophenone (PAPP) is a potent methaemoglobin (MetHb) forming compound in canids. A formulation of PAPP, dimethylsulphoxide (DMS0) and condensed milk was investigated as a new toxicant formulation for delivery by the ejector. Dosage of eight foxes in the laboratory with a sequential dose demonstrated that the formulation caused a dose-dependent and rapid elevation of MetHb. A strong inverse correlation between MetHb and oxyhaemoglobin concentrations was detected in each case. The symptoms of the toxicosis in the laboratory included progressive cyanosis, lethargy and then collapse when MetHb levels reached 56-76%. A polynomial model was a good fit for describing the relationship between sub-lethal doses of PAPP and the resulting peak MetHb levels. In a pen trial, an ejector was fitted with a bait and loaded with a standard dose of 226 mg PAPP in the same formulation and set at one end of a pen. After voluntarily triggering the ejector, all five foxes in this trial became progressively more lethargic and either lay prostrate or collapsed after 14-25 min, and death was confirmed after a mean of 43 min. We compared some clinical features of PAPP toxicosis with 15 cases of lethal sodium fluoroacetate (1080) poisoning using 0.5 mg kg-1 1080. PAPP produced a mean time to death that was 7.7 times faster than 1080, with the onset of first symptoms being 15 times faster. It was associated with much less activity prior to death and convulsions, spasms and paddling commonly associated with 1080 poisoning after collapse were not detected during PAPP toxicosis. We conclude that the PAPP formulation appears to be a rapidly acting and apparently humane lethal agent for fox control when used in conjunction with the ejector.
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McKeefry, Declan J., Neil R. A. Parry, Ian J. Murray, and Athanasios Panorgias. "SPALVOTO STIMULO SUVOKIMAS REGIMOJO LAUKO PERIFERIJOJE." Psichologija 38 (January 1, 2008): 19–28. http://dx.doi.org/10.15388/psichol.2008.0.2607.
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Mes tyrėme, kaip pakinta stimulo spalvos suvokimas, kai stimulas matomas regimojo lauko centre ir kai periferijoje. Lygindami L-M ir S-(L+M) oponentinių sistemų, gaunančių signalus iš centrinės ir periferinės tinklainės dalies, aktyvumą, nustatėme, kad spalvų suvokimo pokyčiai atspindi L-M oponentinės sistemos aktyvumo silpnėjimą periferijoje. S kūgelių įtaka oponentinės sistemos aktyvumui kinta mažiau negu L-M kūgelių. Taigi, dviejų oponentinių sistemų santykinė įtaka spalvos suvokimui periferijoje ir centre pakinta. Straipsnyje tiriama, kokią reikšmę šiems pokyčiams turi tinklainėje ir smegenų žievėje vykstantys procesai. Pagrindiniai žodžiai: spalva, suvokimas, oponentinės ląstelės, centrinė ir periferinė tinklainė.The Perception of Chromatic Stimuli in the Peripheral Human RetinaDeclan J. McKeefry, Neil R. A. Parry, Ian J. Murray, Athanasios Panorgias SummaryWe have studied the changes that occur in human colour perception in the peripheral retina. By modelling the magnitude of activation produced in the L-M and S-(L+M) cone-opponent systems for matched para-foveal and peripheral chromatic stimuli, we have found that variations in perceived appearance are mirrored by a reduction in function of the L-M opponent system. The operation of the S-cone opponent system is affected to a much lesser degree, implying that there is a changing pattern of predominance between the two cone-opponent mechanisms in the peripheral retina. We will explore possible retinal and cortical bases for these changes.Key words: color, perception, opponent processes, central and peripheral retina.
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Heitzmann, E., and H. Javelot. "À propos d’un cas de dyskinésie tardive d’évolution fatale induite par l’aripiprazole." European Psychiatry 30, S2 (November 2015): S157. http://dx.doi.org/10.1016/j.eurpsy.2015.09.317.
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L’aripiprazole peut être considéré comme un antipsychotique de 3e génération et présente théoriquement un faible risque d’induire des symptômes extrapyramidaux. Cependant, des cas de dyskinésies tardives et de dystonies induites par l’aripiprazole sont désormais rapportés assez fréquemment dans la littérature. Nous décrivons ici le cas d’un patient ayant présenté une dyskinésie d’évolution dramatique. À l’automne 2011, alors âgé de 74 ans, M X., qui n’a pas d’antécédent psychiatrique connu, présente un syndrome dépressif majeur pris en charge initialement par une association aripiprazole/escitalopram. En 2012, l’apparition progressive de dyskinésies bucco-linguo-faciales et de mouvements choréiques des membres inférieurs conduisent à l’arrêt de l’aripiprazole. Une IRM ne révèle aucune lésion des noyaux gris ou du tronc cérébral, notamment. Courant 2013 les symptômes sont amandés par l’utilisation de la tétrabénazine. Au cours de l’année suivante, on note successivement l’apparition d’une dyspnée d’effort bruyante sur spasmes diaphragmatiques, puis d’un stridor permanent sur spasme laryngé. La tétrabénazine est arrêtée en novembre 2014 dans un contexte d’aggravation de la symptomatologie dépressive. Le spasme laryngé est amélioré début 2015 par l’injection de toxine botulique, mais l’effet bénéfique s’estompe rapidement. Une nouvelle IRM réalisée en décembre 2014 ne révèle pas d’élément pour une étiologie alternative à l’hypothèse d’une dyskinésie iatrogène. En mars, la tétrabénazine est finalement réintroduite face aux dyskinésies qui persistent et deviennent de plus en plus sévères dans leur intensité. Mr X décède début juillet 2015 suite à un arrêt cardiaque dans un contexte d’insuffisance respiratoire terminale. Ce cas rappelle la prudence indispensable qu’il convient d’adopter dans l’utilisation de l’aripiprazole perçu comme un traitement antipsychotique avec un bon profil de sécurité clinique. Notre patient présentait plusieurs facteurs de risque de dyskinésie tardive incluant un âge avancé, la présence d’un trouble de l’humeur et une exposition à l’antipsychotique sur une durée supérieure à 6 mois.
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Sekti, Fitri Milenia, and Eko Budi Prasetyo. "PENATALAKSANAAN FISIOTERAPI PADA PLANTAR FASCIITIS DENGAN MODALITAS TENS, IR DAN TERAPI LATIHAN DI RSUD KAJEN KABUPATEN PEKALONGAN." Pena Jurnal Ilmu Pengetahuan dan Teknologi 35, no. 2 (October 4, 2021): 40. http://dx.doi.org/10.31941/jurnalpena.v35i2.1567.
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<span style="font-size: 10.0pt; mso-bidi-font-size: 12.0pt; line-height: 115%; font-family: 'Calibri','sans-serif'; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: 'Times New Roman'; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: 'Times New Roman'; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Plantar fasciitis is an inflammation of the plantar fascia. Physiotherapy problems that occur are: (1) The presence of pain in the soles of the feet, (2) The presence of muscle spasm m. gastrocnemius, (3) the limited range of motion of the bilateral ankle joint (4) the presence of bilateral ankle muscle weakness, (5) There is a decrease in functional activity, (6) The presence of tenderness in the calcaneus. This research was conducted at Kajen Hospital, Pekalongan Regency with the design used was a case study on bilateral plantar fasciitis et causa calcaneus spur patients who had been given physiotherapy interventions in the form of tens (transcutaneous eletrical nerve stimulation), infrared, and exercise therapy (free active exercise, calf raises). and active stretching). Methods of data collection and data analysis using auto history. Instruments focused on pain conditions, muscle spasm, LGS, muscle strength, functional activity. Based on the therapy carried out 4 times, the following results were obtained: (1) there was a decrease in pain from T1: 1.8 to T4: 0 (2) there was a decrease in spasm from T1: 1 to T4: 0 (3) there was an increase in ROM dorso flexion right from T1: 15<sup>o</sup> to T4: 25<sup>o</sup>, right eversion from T1: 10<sup>o</sup> to T4: 15<sup>o</sup>, dorso left flexion from T1: 10<sup>o</sup> to T4: 20<sup>o</sup>, left eversion from T1: 5<sup>o</sup> to T4: 15<sup>o</sup>, (4) there is an increase in strength muscle from T1: 4 to T5: 5 (5) there is an increase in daily functional activities. The conclusion of this study is that the TENS (transcutaneous electrical nerve stimulation), infrared, and exercise therapy (free active exercise, calf raises, active stretching) modality can reduce the problems caused by bilateral plantar fasciitis et causa calcaneus spur conditions.</span><h1 style="margin: 0cm; margin-bottom: .0001pt; text-align: justify; text-indent: 1.0cm; line-height: normal;"><span style="font-size: 10.0pt; mso-bidi-font-size: 12.0pt; font-weight: normal; mso-bidi-font-weight: bold;" lang="IN">Plantar fasciitis is an inflammation of the plantar fascia. Physiotherapy problems that occur are: (1) The presence of pain in the soles of the feet, (2) The presence of muscle spasm m. gastrocnemius, (3) the limited range of motion of the bilateral ankle joint (4) the presence of bilateral ankle muscle weakness, (5) There is a decrease in functional activity, (6) The presence of tenderness in the calcaneus. This research was conducted at Kajen Hospital, Pekalongan Regency with the design used was a case study on bilateral plantar fasciitis et causa calcaneus spur patients who had been given physiotherapy interventions in the form of tens (transcutaneous eletrical nerve stimulation), infrared, and exercise therapy (free active exercise, calf raises). and active stretching). Methods of data collection and data analysis using auto history. Instruments focused on pain conditions, muscle spasm, LGS, muscle strength, functional activity. Based on the therapy carried out </span><span style="font-size: 10.0pt; mso-bidi-font-size: 12.0pt; mso-ansi-language: EN-US; font-weight: normal; mso-bidi-font-weight: bold;">4</span><span style="font-size: 10.0pt; mso-bidi-font-size: 12.0pt; font-weight: normal; mso-bidi-font-weight: bold;" lang="IN"> times, the following results were obtained: (1) there was a decrease in pain from T1: 1.8 to T4: 0 (2) there was a decrease in spasm from T1: 1 to T4: 0 (3) there was an increase in ROM dorso flexion right from T1: 15<sup>o</sup> to T4: 25<sup>o</sup>, right eversion from T1: 10<sup>o</sup> to T4: 15<sup>o</sup>, dorso left flexion from T1: 10<sup>o</sup> to T4: 20<sup>o</sup>, left eversion from T1: 5<sup>o</sup> to T4: 15<sup>o</sup>, (4) there is an increase in strength muscle from T1: 4 to T5: 5 (5) there is an increase in daily functional activities. The conclusion of this study is that the TENS (transcutaneous electrical nerve stimulation), infrared, and exercise therapy (free active exercise, calf raises, active stretching) modality can reduce the problems caused by bilateral plantar fasciitis et causa calcaneus spur conditions.</span></h1>
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Reunanen, Justus, Ingemar von Ossowski, Antoni P. A. Hendrickx, Airi Palva, and Willem M. de Vos. "Characterization of the SpaCBA Pilus Fibers in the Probiotic Lactobacillus rhamnosus GG." Applied and Environmental Microbiology 78, no. 7 (January 13, 2012): 2337–44. http://dx.doi.org/10.1128/aem.07047-11.
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ABSTRACTLactobacillus rhamnosusGG is a human intestinal isolate that has been studied intensively because of its probiotic properties. We have previously shown thatL. rhamnosusGG produces proteinaceous pili that earlier had been observed only in Gram-positive pathogens (M. Kankainen et al., Proc. Natl. Acad. Sci. U. S. A.106:17193–17198, 2009). These pili were found to be encoded by thespaCBAgene cluster, and the pilus-associated SpaC pilin was shown to confer on the cells a mucus-binding ability. In addition to thespaCBAcluster, another putative pilus cluster,spaFED, was predicted from theL. rhamnosusGG genome sequence. Herein, we show that only SpaCBA pili are produced byL. rhamnosus, and we describe a detailed analysis of cell wall-associated and affinity-purified SpaCBA pili by Western blotting and immunogold electron microscopy. Our results indicate that SpaCBA pili are heterotrimeric protrusions with a SpaA subunit as the shaft-forming major pilin. Only a few SpaB subunits could be observed in pilus fibers. Instead, SpaB pilins were found at pilus bases, as assessed by immunogold double labeling of thin sections of cells, suggesting that SpaB is involved in the termination of pilus assembly. The SpaC adhesin was present along the whole pilus length at numbers nearly equaling those of SpaA. The relative amount and uniform distribution of SpaC within pili not only makes it possible to exert both long-distance and intimate contact with host tissue but also provides mucus-binding strength, which explains the prolonged intestinal residency times observed forL. rhamnosusGG compared to that of nonpiliated lactobacilli.
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Morgoshiia, Temuri Sh, and Nikolai A. Siroejin. "Professor Max Wilms: 150th anniversary of birth - in memoriam." Pediatrician (St. Petersburg) 8, no. 6 (December 28, 2017): 131–34. http://dx.doi.org/10.17816/ped86131-134.
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The research activity of M. Wilms is characterized by diversity of its objects and breadth of breadth of its scope. A surgeon-oncologist, he is known to have devoted a number of his studies, to purely theoretical issues of Oncology. On the other hand, M. Wilms contributed to the development of clinical surgery and Oncology, offering a number of new methods of diagnostics and treatment of major forms of malignant tumors of the genital organs and kidney, making a significant contribution to the practice of world medicine. Classical studies of teratogenic tumors of the ovaries and testicles, mixed tumors, tumors of kidney belong to M. Wilms. The tumor described by M. Wilms in 1899 which is named after him is one of the most frequent malignancies in children usually occurring at the age of 2-5 years but which can also occur at any age, even in very old patients. In the same year his famous monograph “Mixed tissue tumor of the kidney” was published. In 1904 M. Wilms was awarded the title of Professor, and two years later he published his fundamental work “Intestinal obstruction – pathology and clinic” (1906), which brought M. Wilms fame and recognition among surgeons, oncologists and pathologists all over the world. M. Wilms also made contribution into pediatric surgery. In 1906 he proposed to classify the intussusception types, depending on the name of the colon which forms the intussusception head (the iliac colon, caecum, etc.). Analyzing the etiology of Hirschsprung's disease Max Wilms is known to have adhered to the theory of prolonged spasm of the anal canal and, consequently, to inception of secondary megacolon (1904). His assumptions he confirmed by performing manometric studies at the level of the anal canal of the rectum, and in the treatment he applied the method of anal bougienage. A talented scientist and teacher, demanding and fastidious towards himself and his disciples, Max Wilms published more than 130 research papers, of most of which he was the sole author.
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Bai, Ruifeng, Xinrui Liu, Shan Jiang, and Haijiang Sun. "Deep Learning Based Real-Time Semantic Segmentation of Cerebral Vessels and Cranial Nerves in Microvascular Decompression Scenes." Cells 11, no. 11 (June 2, 2022): 1830. http://dx.doi.org/10.3390/cells11111830.
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Automatic extraction of cerebral vessels and cranial nerves has important clinical value in the treatment of trigeminal neuralgia (TGN) and hemifacial spasm (HFS). However, because of the great similarity between different cerebral vessels and between different cranial nerves, it is challenging to segment cerebral vessels and cranial nerves in real time on the basis of true-color microvascular decompression (MVD) images. In this paper, we propose a lightweight, fast semantic segmentation Microvascular Decompression Network (MVDNet) for MVD scenarios which achieves a good trade-off between segmentation accuracy and speed. Specifically, we designed a Light Asymmetric Bottleneck (LAB) module in the encoder to encode context features. A Feature Fusion Module (FFM) was introduced into the decoder to effectively combine high-level semantic features and underlying spatial details. The proposed network has no pretrained model, fewer parameters, and a fast inference speed. Specifically, MVDNet achieved 76.59% mIoU on the MVD test set, has 0.72 M parameters, and has a 137 FPS speed using a single GTX 2080Ti card.
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Grossniklaus, Hans E. "Microvascular decompression to treat hemifacial spasm: long-term results for consecutive series of 143 patients. Samii M, Gunther T, Iaconetta G, Muehling M, Vorkapic P, Samii A. Neurosurgery 2002;50:712–719." American Journal of Ophthalmology 134, no. 3 (September 2002): 476. http://dx.doi.org/10.1016/s0002-9394(02)01661-6.
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Thomas, Christine K., Charlotte K. Häger, and Cliff S. Klein. "Increases in human motoneuron excitability after cervical spinal cord injury depend on the level of injury." Journal of Neurophysiology 117, no. 2 (February 1, 2017): 684–91. http://dx.doi.org/10.1152/jn.00676.2016.
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After human spinal cord injury (SCI), motoneuron recruitment and firing rate during voluntary and involuntary contractions may be altered by changes in motoneuron excitability. Our aim was to compare F waves in single thenar motor units paralyzed by cervical SCI to those in uninjured controls because at the single-unit level F waves primarily reflect the intrinsic properties of the motoneuron and its initial segment. With intraneural motor axon stimulation, F waves were evident in all 4 participants with C4-level SCI, absent in 8 with C5 or C6 injury, and present in 6 of 12 Uninjured participants ( P < 0.001). The percentage of units that generated F waves differed across groups (C4: 30%, C5 or C6: 0%, Uninjured: 16%; P < 0.001). Mean (±SD) proximal axon conduction velocity was slower after C4 SCI [64 ± 4 m/s ( n = 6 units), Uninjured: 73 ± 8 m/s ( n = 7 units); P = 0.037]. Mean distal axon conduction velocity differed by group [C4: 40 ± 8 m/s ( n = 20 units), C5 or C6: 49 ± 9 m/s ( n = 28), Uninjured: 60 ± 7 m/s ( n = 45); P < 0.001]. Motor unit properties (EMG amplitude, twitch force) only differed after SCI ( P ≤ 0.004), not by injury level. Motor units with F waves had distal conduction velocities, M-wave amplitudes, and twitch forces that spanned the respective group range, indicating that units with heterogeneous properties produced F waves. Recording unitary F waves has shown that thenar motoneurons closer to the SCI (C5 or C6) have reduced excitability whereas those further away (C4) have increased excitability, which may exacerbate muscle spasms. This difference in motoneuron excitability may be related to the extent of membrane depolarization following SCI. NEW & NOTEWORTHY Unitary F waves were common in paralyzed thenar muscles of people who had a chronic spinal cord injury (SCI) at the C4 level compared with uninjured people, but F waves did not occur in people that had SCI at the C5 or C6 level. These results highlight that intrinsic motoneuron excitability depends, in part, on how close the motoneurons are to the site of the spinal injury, which could alter the generation and strength of voluntary and involuntary muscle contractions.
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Amin, Abd Samad. "Stellate Ganglion Block as Pain Management in Post Herpetic Neuralgia: A Case Report." Journal of Anesthesiology and Clinical Research 3, no. 2 (October 28, 2022): 332–35. http://dx.doi.org/10.37275/jacr.v3i2.254.
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Introduction: Stellate ganglion block (SGB) has been used in various conditions. Medical conditions include complex regional pain syndrome and peripheral vascular disease. This study aims to describe the use of stellate ganglion block for pain management in post-herpetic neuralgia.
Case presentation: A 68-year-old man came with a complaint of severe headache. Complaints of severe headache since 1 month ago, pain until tears come out. This complaint is accompanied by red blisters, pain on the left side of the face, weakness, and decreased appetite. Physical examination showed compos mentis consciousness, appeared moderately ill, blood pressure 160/90 mmHg, heart rate 112x/minute, respiratory rate 20x/minute, temperature 37.2oC, numeric rating scale 7/10. In the head region, there was cicatricial, paresis of N VII, positive hypersensibility, positive allodynia, spasm neck muscles, right joint shoulder stiffness, and stiffness in the m. right rotator cuff. The patient was given intervention in the form of a stellate ganglion block (SGB). Follow-up 1 day after the GBS procedure showed that the headache and left facial pain were greatly reduced.
Conclusion: Ultrasonographic-guided stellate ganglion block can reduce post-herpetic neuralgia symptoms with minimal complications.
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Ellegård, Alvar, Sabina Kielow, Arne Olofsson, Ronald Paul, Ted Tapper, Magnus Ankarsjö, Monica Armini, et al. "Reviews and notices." Moderna Språk 93, no. 2 (December 1, 1999): 238–55. http://dx.doi.org/10.58221/mosp.v93i2.9703.
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Includes the following reviews:
p. 238. Alvar Ellegård. Svartvik, J., Engleska - öspråk, världsspråk, trendspråk.
p. 239. Sabina Kielow. Ryan, M., Literary Theory. + Widdowson, P., Literature. The New Critical Idiom.
p. 239-243. Arne Olofsson. Olsson, H., Språket - så fungerar det. Lärobok i allmän grammatik och lingvistik.
p. 243-244. Ronald Paul. Ellegård, A., Jesus, One Hundred Years Before Christ: A Study in Creative Mythology.
p. 244-245. Ted Tapper. Löfgre, H. & Shima, A. (eds), After Consensus: Critical Challende and Social Change in America.
p. 245-246. Magnus Ankarsjö. Mahood, M.M., Playing Bit Parts in Shakespeare.
p. 246-247. Monica Armini. Mikalachki, J., The Legacy of Boadicea: Gender and Nation in Early Modern England.
p. 247-249. Esbjörn Nyström. Packalén, S., Im Spiegel der Literatur. Den tyskspråkiga litteraturen under tolv hundra år.
p. 249-251. Christine Pankow/Ingmar Söhrman. Nordstedts bildordbok. Svenska, Engelska, Tyska, Franska.
p. 251-253. Gösta Björn. Kirsch, F. -M., Stille aber ist Mangelware. Deutschland und die Deutschen in schwedischen Schulbüchern für das Fach Deutsch 1970-1995.
p. 253-254. Frank-Michael Kirsch. Müller Waldeck, G. & Ulrich, R. (Hrsg.), Hans Fallada: Sein Leben in Bildern und Briefen.
p. 254-255. Ingmar Söhrman. Nordstedts spanska ordbok. Spansk - svensk, svensk - spansk.
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Karademir, F., A. E. Yildiz, T. Firat, and O. Ulger. "AB1819-HPR INTRA-RATER RELIABILITY OF SHEAR WAVE ELASTOGRAPHY FOR THE QUANTIFICATION OF THUMB MUSCLE ELASTICITY." Annals of the Rheumatic Diseases 82, Suppl 1 (May 30, 2023): 2141.2–2141. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2931.
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BackgroundShear wave elastography (SWE) is a technique that evaluates tissue elasticity by applying an acoustic radiation force impulse [1]. It is undetermined how reliable this modality is in assessing thumb muscles. Quantitative evaluation of muscle stiffness in conditions such as trapeziometacarpal osteoarthritis where increased fibrosis, muscle tone, spasm, and contractures can be seen can provide important information about the pathophysiology and prognosis of the diseases [2].ObjectivesThis study aimed to assess the intra-rater reliability of thumb muscle elasticity and thickness in healthy people.MethodsTen healthy participants (20 hands) enrolled in the study. Thickness and shear wave velocity (SWV) of adductor pollicis (AdP) and first dorsal interosseous (FDI) muscles were obtained using an ACUSON S3000 Ultrasonography System and a 9L4 probe (4-9 MHz) (Siemens Medical Solutions, Mountain View, California). Ultrasound data (SWV, thickness) were collected and analyzed by an experienced radiologist. Three repeated SWV and thickness measurements were recorded in the resting position and an average was taken. Two sessions were performed at a 15-minutes interval.ResultsTen healthy participants (20 hands; 5 female; 5 male; mean age: 25.9±2.68 years; BMI: 22.4±1.39 kg/m2) were included in this study. Nine subjects had right-hand dominancy and 1 had left-hand dominancy. The mean (±SEM) shear wave velocity for the AdP was 1.86 ± 0.6 m/s (=10.86 kPa), and for the FDI was 1.76 ± 0.5 m/s (=9.72 kPa). The intra-rater trial agreement was excellent, with intraclass correlation coefficients of 0.887 and 0.828 respectively. The mean (±SEM) muscle thickness for the AdP was 12.4 ± 3.93 mm, and for the FDI was 12.0 ± 3.68 mm. The intra-rater trial agreement was excellent, with intraclass correlation coefficients of 0.953 and 0.984 respectively.ConclusionSWE ultrasound was a reliable imaging technique to assess the stiffness and thickness of thumb muscles.References[1]Taljanovic, M. S., Gimber, L. H., Becker, G. W., Latt, L. D., Klauser, A. S., Melville, D. M., Witte, R. S. (2017). Shear-wave elastography: basic physics and musculoskeletal applications. Radiographics, 37(3), 855-870.[2]Neumann, D. A., & Bielefeld, T. (2003). The carpometacarpal joint of the thumb: stability, deformity, and therapeutic intervention. Journal of Orthopaedic & Sports Physical Therapy, 33(7), 386-399.Acknowledgements:NIL.Disclosure of InterestsNone Declared.
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Farag, Zahra Hassan Abdelaziz, and Elhadi Mohieldin Awooda. "Dental Erosion and Dentin Hypersensitivity among Adult Asthmatics and Non-asthmatics Hospital-based: A Preliminary Study." Open Dentistry Journal 10, no. 1 (November 4, 2016): 587–93. http://dx.doi.org/10.2174/1874210601610010587.
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Background: Asthma is a chronic inflammatory condition affecting the airways leading to spasm and swelling of the airways. The medications taken for the treatment of asthma can result in dental erosion and dentin hypersensitivity. Objectives: The aims of this study were to investigate the severity of dental erosion amongst adult asthmatics according to: gender, type and duration of medication taken and to compare dental erosion and dentin hypersensitivity between asthmatics and non-asthmatics. Subjects and Methods: Comparative, cross-sectional hospital based study among 40 asthmatics (M=15 & F=25) and 40 non-asthmatics (M=18 & F=22) in the age range of 18-60 year selected purposefully from Al-Shaab Teaching Hospital in Khartoum city. The Basic Erosive Wear Index was used for dental erosion assessment. Dentine hypersensitivity was determined by giving ice cold water and rated using the Visual Analogue Scale. Chi-square and Student’s t-test were used for statistical analysis with P value ≤.05. Results: There was an association between severity of dental erosion and presence of asthma (P=0.03), where asthmatics had a higher degree of erosion (moderate and severe) and non-asthmatics a lower degree. No significant association was found between dental erosion and gender, type and duration of medication among asthmatics group. A statistically significant difference was revealed in the degree of dentin hypersensitivity (P=0.00) among asthmatics (35.13%) and non-asthmatics (14.13%). Conclusion: Asthmatic patients had a higher degree of dental erosion and dentin hypersensitivity compared to non-asthmatics. Among asthmatic patients there was no association between severity of dental erosion and gender, type and duration medication was taken for.
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Yoshikawa, Kenichi, Hirotaka Mutsuzaki, Kazunori Koseki, Yusuke Endo, Yuko Hashizume, Ryo Nakazawa, Toshiyuki Aoyama, Arito Yozu, and Yutaka Kohno. "Gait Training Using a Wearable Robotic Device for Non-Traumatic Spinal Cord Injury: A Case Report." Geriatric Orthopaedic Surgery & Rehabilitation 11 (January 1, 2020): 215145932095696. http://dx.doi.org/10.1177/2151459320956960.
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Introduction: We aimed to report the clinical evaluation results of gait training with the Honda Walking Assist Device® (HWAT) in a patient with spinal cord injury (SCI). Patients and Methods: A 63-year-old male with SCI (grade D on the American Spinal Injury Association Impairment Scale) underwent 20 HWAT sessions over 4 weeks. The self-selected walking speed (SWS), mean step length, cadence, 6-minute walking test (6MWT), Walking Index for SCI score, SCI Functional Ambulation Inventory gait score, American Spinal Injury Association Impairment Scale grade, neurological level, upper and lower extremity motor scores, modified Ashworth Scale, Penn Spasm Frequency Scale, and Spinal Cord Independence Measure version III were measured on admission, at the start of HWAT, at 2 and 4 weeks post-HWAT, and at discharge. Three-dimensional kinematic gait analysis and electromyographic assessments were performed before and after HWAT. Results: The patient safely completed 20 HWAT sessions. We found improvements above the clinically meaningful difference in SWS and 6MWT as well as increased hip extension, ankle plantar- and dorsi-flexion range of motion and increased hip extensor, abductor, adductor, and ankle plantar flexor muscle activity. Discussion: The SWS improved more markedly during the HWAT intervention, exceeding the minimal clinically important difference (0.10 to 0.15 m/s) in walking speed for people with SCI until discharge. Moreover, the 6MWT results at 2 weeks after the start of HWAT exceeded the cutoff value (472.5 m) for community ambulation and remained at a similar value at discharge. Conclusion: The walking distance (6MWT) and the walking speed (SWS) both demonstrated clinically important improvements following 20 treatment sessions which included HWAT.
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Takada, Rei, Takenori Tozawa, Hidehito Kondo, Zenro Kizaki, Yoshihito Kishita, Yasushi Okazaki, Kei Murayama, Akira Ohtake, and Tomohiro Chiyonobu. "Early infantile-onset Leigh syndrome complicated with infantile spasms associated with the m.9185 T > C variant in the MT-ATP6 gene: Expanding the clinical spectrum." Brain and Development 42, no. 1 (January 2020): 69–72. http://dx.doi.org/10.1016/j.braindev.2019.08.006.
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Antivalle, M., M. Agosti, A. Batticciotto, S. Costi, V. Giorgi, and P. Sarzi Puttini. "THU0454 SOMATIC SYMPTOMS IN FIBROMYALGIA AND THEIR CORRELATION WITH DRUG TREATMENT." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 464.2–464. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6427.
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Background:Drug treatment in fibromyalgia (FM) is often disappointingly ineffective, and there are currently very few data to support therapeutic choices towards a personalized medicine approach.Objectives:To evaluate the prevalence of selected somatic symptoms in FM, and to study their relationship with drug treatments.Methods:The study population consisted of 526 patients (471 F 55 M, mean age 47.31±11.33 yrs) affected by FM not associated with other rheumatic diseases. All patients were required to compile a questionnaire reporting the presence of 42 somatic symptoms -as suggested (1) – in the last 7 days. Drug usage was assessed by interview.Results:On average, patients reported the presence of 17.04±6.68 symptoms (range 4-35), with ample variations in the prevalence of different symptoms (Fig. 1), ranging from over 95% (fatigue and muscle pain) to less than 10 %, seizures being reported by only 2 patients (0.4%). 31.1% of patients were not taking any drug for their FM. The most frequently used drugs were analgesics (ANA, 41.7%) followed by benzodiazepines (BD, 29.1%), SSRIs (16%), gabapentinoids (GABA, 14,4%), and NSRI (14.3%) (Fig. 2). Different drugs were associated with a different spectrum of somatic symptoms: as compared to non users, BD users reported a significantly higher (p< 0.05 by chi-square test) prevalence of irritable bowel (65.4% vs 52.3%), fatigue (98.7% vs 94.9%), thinking difficulties (78.4% vs 68.5%), muscle weakness (94.1% vs 81.7%), abdominal pain (55.6% vs 43.9%), insomnia (73.9% vs 56.6%), depression (63.4 % vs 37.2%), constipation (60.1% vs 42.9%), pain in upper abdomen (50.3% vs 40.2%), nausea (53.6% vs 38.3%), nervousness (71.9% vs 61.5%), chest pain (49.0 vs 37.75), blurred vision (65.4% vs 53.6%), dry mouth (72.5% vs 52.3%), itching (56.2% vs 44.5%), vomiting (13.7% vs 7.8%), taste change (22.2% vs 12.7%), dry eyes (55.6% vs 41.0%), breath shortness (56.9% vs 47.7%), appetite loss (33.3% vs 19.7%), painful urination (15.0% vs 8.4%), and bladder spasms (18.3% vs 8.6%). NRSI users reported a significantly higher prevalence of thinking difficulties, constipation, blurred vision, dry mouth, wheezing, dry eyes, easy bruising. Among GABA users, there was a higher prevalence of thinking difficulties, numbness, insomnia, constipation, nausea, dry mouth, dry eyes, appetite loss, sun sensitivity, easy bruising, and bladder spasms. In no cases a higher prevalence of symptoms was recorded in drug non users vs users.Conclusion:The usage of different drugs in FM is associated with different somatic symptoms. The higher prevalence of symptoms in drug users as compared to non users raises serious questions concerning the opportunity or the appropriateness of drug selection in FM.References:[1]Wolfe F., et al. Arthritis Care Res (Hoboken). 2010 May;62(5):600-10Disclosure of Interests: :None declared
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Pradhan, Rabindra Lal, Bimal Kumar Pandey, Sashmit Sharma, Shishir Lakhey, Rajiv Raj Manadhar, Kiran Prasad Rijal, and Tanup Prasai. "Conservative treatment of TB Spondylitis in Dorsolumbar and Lumbar spine." Nepal Orthopaedic Association Journal 3, no. 2 (January 8, 2014): 33–37. http://dx.doi.org/10.3126/noaj.v3i2.9526.
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Introduction: Tuberculosis (TB) is endemic in South Asia including Nepal. TB spine is the most common musculoskeletal manifestations and can have devastating complications. Early diagnosis by proper history, physical and radiological examination is mandatory. Chemotherapy is effective in most cases while some require surgical treatment. Methods: Forty-four patients with clinico-radiological evidence of TB were treated with four drug regime for 18 months and all patients were followed up till the end of the chemotherapy. Results: All 44 patients (M-28/ F-16) had back pain not responding to analgesics and physiotherapy while few had constitutional symptoms. Localized tenderness and paravertebral muscle spasm was present in 32/44 (72.7%) and the rest had palpable swelling at the dorsolumbar and lumbar regions. According to the classification by Oguz et al. the majority of the patients were in the Type I B. Six patients who did not show any improvement in pain and resolution of swelling were admitted and two more drugs (Steptomycin and Ofloxacin) were added. Conclusions: Conservative treatment of TB spondylitis of the lumbar spine can be treated with chemotherapy and appropriate investigations should be performed in patients with back pain who do not respond to rest, analgesics and physiotherapy. DOI: http://dx.doi.org/10.3126/noaj.v3i2.9526 NOAJ July-December 2013, Vol 3, Issue 2, 33-37
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Djezzar, S., F. Vorspan, D. Chataigner, E. Burin, R. Garnier, and J. P. Lépine. "Mephenesin dependence: A case series." European Psychiatry 26, S2 (March 2011): 29. http://dx.doi.org/10.1016/s0924-9338(11)71740-0.
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IntroductionMephenesin is a central muscle relaxant, acting through a depression of the activity of some neurones in the caudate nucleus. It was proposed as a potential treatment of alcohol withdrawal syndrome in the 50s. This over the counter medicine is now mainly prescribed to treat spasticity or as an adjunctive treatment of painful muscle spasm. We know little about this substance except that side effects are venous thrombosis, haemolysis or cutaneous intolerance. Yet, no case of abuse or dependence has been reported.AimsTo report a series of 5 clinical cases in patients who developed abuse or dependence to mephenesin.MethodsWe performed a systematic search in data bases of both Paris addictovigilance and poison centres from 1999 to 2010. Clinical details were obtained from clinicians when possible. A literature search was also performed to describe mephenesin mechanisms of actions that could be implied.ResultsThree (3) women et 2 men aged 35 to 52 years (m : 43.6) were identified as abusing mephenesin, among which 4 patients had a full DSM IV criteria of dependence. All had a previous history of abuse or substance dependence (alcohol, heroin, codeine, ketamine…).The average mephenesin daily intake was 13 g (9 to 24 g) when the maximum recommended dosage is 3 gr/d. In one case, a withdrawal syndrome was observed (tremor, aggressiveness).ConclusionMephenesin may be abused by patients with previous risk factors, especially a personal history of alcohol dependence.
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Qaiyyum, Ifra Abdul, Mohammad Nawab, Ayesha Aijaz, and Anam Farah. "A REVIEW ON PHYTOCONSTITUENTS AND THERAPEUTIC USES OF MUQIL (COMMIPHORA MUKUL)." Indian Journal of Unani Medicine 15, no. 01 (2022): 33–41. http://dx.doi.org/10.53390/ijum.2022.15106.
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Muqilis one of the best drugs in traditional system of medicine since ancient. It belongs to Burseraceae family, has 540 species and is found in dry area of India known as Indian bdellium. It is bushy plant 1.2-1.8 m can provide yellowish gum resin also called as gugulipid. Most commonly gum of this plant used for therapeutic and medicinal purpose. According to Unani system of medicine (USM) it has two types: 1. Muqil-e-Saqalibi, 2. Muqil-e-Arabi. The plant Commiphora mukul is also known as Balsamodendron mukul Stock. Muqil has active constituents producing number of biological activities such as Antiinflammatory effect (guggulsterones Z and E), Osteoprotective effect (guggulsterone), Anti- inflammatory, analgesic antiarthritic activities (Guggulsterone), Anti-diabetic effect (gum resin 900 mg daily), Antimicrobial, antibacterial, antiviral and antifungal activities (Eugenol, ellagic acid alpha-pinene, masumbinoic acid and masumbinone), Anti-hemorrhoid activity (Muqil resin), Anti-neoplastic activity (GS, gugulipid and Z-guggusterone), Cardioprotective effect (gugulipid and guggusterone), Nephroprotective effect, Nodulocystic Acne (Guggulipid), Neuroprotective effects (guggulipid), Immunomodulatory effect, Stimulate Thyroid gland activity (Commiphora mukul gum) Anti-asthmatic (300 mg of gum resin thrice daily), Inflammatory Bowel Disease (gum resin at a dose of 900 mg daily). It is also useful for systemic disease such as Osteoarthritis, Rheumatoid arthritis, Gout, Cadio-protective effect and thyro-protective effect, nervous diseases and urinarydiseases. Skin disorders are leprosy, pyorrhea, muscle spasm, demulcent, and depurative.
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Pepó, Péter. "Correlation analysis of the SPAD readings and yield of sweet potato (Ipomoea batatas L.) under different agrotechnical conditions." MAY 2020, no. 14(05):2020 (May 20, 2020): 761–65. http://dx.doi.org/10.21475/ajcs.20.14.05.p2124.
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We studied the effect of planting method (flat and ridge planting) and row spacing (0.75-1.0 m) on the yield and SPAD readings of sweet potato (Ásotthalmi 12 variety) in a small-plot field experiment in 2017 and 2018. The experiment was set up in lattice design with 4 replications. The SPAD readings of sweet potato were measured four (2017) and three (2018) times during vegetation period (by Konica Minolta 502). A high yield level was reached both in 2017 (23.23-50.69 t ha-1 marketable yield) and 2018 (33.26-47.34 t ha-1) due to the effects of the favourable soil (chernozem), the near-optimal agrotechnical background, irrigation and the warmer-than-average vegetation period. In both years, higher yields were obtained with flat planting and 0.75 m row spacing. The proportion of non-marketable tubers was between 9.97-15.57% in 2017 and 8.65-11.01% in 2018. The SPADmax values were measured in July (39.61-50.31 in 2017) and in August (49.90-55.33 in 2018). Strong correlation observed among SPAD readings, the whole yield and the marketable yield in both years (r = 0.632*, r = -0.664* and r = 0.709**, respectively). Also, a strong correlation was observed between the planting method and the obtained SPAD readings (r = -0.847**, -0.682* in 2017 and r = -0.634*, -0.488 in 2018, respectively), while there was no correlation between row spacing and SPAD readings (r = -0.006NS-0.190NS). Crop year had a strong effect on SPAD readings (r = 0.639**-0.871**).