Log in

Relevant bibliographies by topics / Lymph node

Contents

Journal articles
Dissertations / Theses
Books
Book chapters
Conference papers
Reports

Academic literature on the topic 'Lymph node'

Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Lymph node.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Lymph node"

1

Tran, Bao Ngoc N., Arthur R. Celestin, Bernard T. Lee, Jonathan Critchlow, Leo Tsai, Beau Toskich, and Dhruv Singhal. "Quantifying Lymph Nodes During Lymph Node Transplantation." Annals of Plastic Surgery 81, no. 6 (December 2018): 675–78. http://dx.doi.org/10.1097/sap.0000000000001571.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Strauchen, James A., and Lorraine K. Miller. "Lymph Node Infarction." Archives of Pathology & Laboratory Medicine 127, no. 1 (January 1, 2003): 60–63. http://dx.doi.org/10.5858/2003-127-60-ln.

Full text

Abstract:

Abstract Context.—The etiology of lymph node infarction may be difficult or impossible to determine by histologic examination. Lymph node infarction is followed by malignant lymphoma in some but not all patients. The role of immunohistochemistry in the evaluation of lymph node infarction is not well defined. Although it is widely believed that necrotic tissue is not suitable for immunohistochemical study, this view may be inaccurate. Objective.—To determine whether lymphoid antigens are preserved in infarcted lymph nodes and to determine the utility of immunohistochemical staining in the evaluation of lymph node infarction. Design.—Retrospective immunohistochemical study of infarcted lymph nodes using archival formalin-fixed, paraffin-embedded tissue. Setting.—Academic medical center. Patients.—Eleven adult patients with lymph node infarction retrieved from pathology files. Main Outcome Measures.—Results of immunohistochemistry, diagnosis of lymphoma. Results.—Preservation of lymphoid antigens was observed in 4 of 6 cases of lymph node infarction associated with malignant lymphoma, including 3 of 5 cases of diffuse large B-cell lymphoma and 1 case of peripheral T-cell lymphoma. Nonspecific staining was not encountered. In 1 case, in which an infarcted lymph node showed a benign pattern of lymphoid antigen expression, lymphoma has not developed after 5 years. Conclusion.—Lymphoid antigens are frequently preserved in cases of lymph node infarction, and immunohistochemical study of infarcted lymph nodes may provide clinically useful information.

APA, Harvard, Vancouver, ISO, and other styles

3

Li, Jiancheng, and Xiuling Shi. "PS02.131: PATTERN OF LYMPHATIC METASTASIS OF CERVICAL ESOPHAGEAL CANCER." Diseases of the Esophagus 31, Supplement_1 (September 1, 2018): 158. http://dx.doi.org/10.1093/dote/doy089.ps02.131.

Full text

Abstract:

Abstract Background Cervical esophageal cancer were rarely surgeryed Analysis and discussion of lymph node metastasis of cervical esophageal cancer Methods From July 2008 to June 2017, 10 cases of successful esophagectomy of cervical esophageal cance in our hospital underwent radical resection. Surgical dissection range was the neck and the upper mediastinum. A total of 231 lymph nodes were dissected. The lymph nodes were summarized and grouped in different ways, and analyzed the law of lymph node metastasis. Results 7 cases of esophageal cancer, lymph node metastasis occurred, and the rate of lymph node metastasis was 70% (7/10), of which 1 case was T1b stage. 17 lymph node metastases, the degree of lymph node metastasis was 7.36% (17/231), including 4 esophageal lymph nodes, 12 cervical lymph nodes and 1 upper right mediastinal lymph node. Conclusion Cervical esophageal cancer lymph node metastasis can spread occur early metastasis, and the metastasis site were mainly in neck.. Disclosure All authors have declared no conflicts of interest.

APA, Harvard, Vancouver, ISO, and other styles

4

Suciu, Nicolae, Orsolya Bauer, Zalán Benedek, Radu Ghenade, Marius Coroș, and Rareș Georgescu. "Study of Survival in Gastric Cancer with Emphasis on Lymph Node Status as an Independent Prognostic Factor." Journal of Interdisciplinary Medicine 4, no. 4 (December 1, 2019): 185–89. http://dx.doi.org/10.2478/jim-2019-0031.

Full text

Abstract:

Abstract Background: Lymph node status in gastric cancer is known as an independent prognostic factor that guides the surgical and oncological treatment and independently influences long-term survival. Several studies suggest that the lymph node ratio has a greater importance in survival than the number of metastatic lymph nodes. Aim: The aim of this study was to evaluate the clinical and morphological factors that can influence the survival of gastric cancer patients, with an emphasis on nodal status and the lymph node ratio. Material and methods: We conducted a retrospective study in which 303 patients with gastric cancer admitted to the Department of Surgery of the Mureș County Hospital between 2008 and 2018 were screened for study enrolment. Data were obtained from the records of the department and from the histopathological reports. The examined variables included: age, gender, tumor localization, T stage, histological type, grade of differentiation, surgical procedure, lympho-vascular invasion, excised lymph nodes, metastatic lymph nodes, lymph node ratio. After screening, the study included a total number of 100 patients, for which follow-up data was available. Results: The mean age of the study population was 66.43 ± 10 years, and 71% were males. The average survival period was 21.42 months. Statistical analysis showed that the localization of the tumor (p = 0.021), vascular invasion (p ---lt---0.001), T (p = 0.004) and N (p ---lt---0.001) stages, type of surgery (partial gastrectomy 59% vs. total gastrectomy 41%, p = 0.005), as well as the lymph node ratio (p ---lt---0.001) were prognostic factors for survival in patients with gastric cancer undergoing surgical therapy. Conclusions: The survival of gastric cancer patients is significantly influenced by tumor localization, T stage, vascular invasion, type of surgery, N stage and the lymph node ratio based on univariate analysis. Also, the lymph node ratio proved to be an independent prognostic factor for survival.

APA, Harvard, Vancouver, ISO, and other styles

5

Leibold, Tobias, Jinru Shia, Leyo Ruo, Bruce D. Minsky, Timothy Akhurst, Marc J. Gollub, Michelle S. Ginsberg, et al. "Prognostic Implications of the Distribution of Lymph Node Metastases in Rectal Cancer After Neoadjuvant Chemoradiotherapy." Journal of Clinical Oncology 26, no. 13 (May 1, 2008): 2106–11. http://dx.doi.org/10.1200/jco.2007.12.7704.

Full text

Abstract:

Purpose After preoperative chemoradiotherapy of rectal cancer, the number of retrievable and metastatic lymph nodes is decreased. The current TNM classification is based on number and not location of lymph node metastases and may understage disease after chemoradiotherapy. The aim of this study was to examine the prognostic significance of location of involved lymph nodes in rectal cancer patients after preoperative chemoradiotherapy. Patients and Methods We prospectively examined whole-mount specimens from 121 patients with uT3-4 and/or N+ rectal cancer who received preoperative chemoradiotherapy followed by resection. Location of involved lymph nodes was compared with median number of lymph nodes involved as well as presence of distant metastasis at presentation. Results Lymph node metastases were detected in 37 patients (31%). Thirteen patients with lymph node involvement along major supplying vessels (proximal lymph node metastases) had a significantly higher rate of distant metastatic disease at time of surgery than patients without proximal lymph node involvement (P < .001); median number of lymph nodes involved was two for patients with proximal lymph node metastases and 1.5 for patients with mesorectal lymph node involvement alone. Conclusion Our data suggest that, after preoperative chemoradiotherapy, proximal lymph node involvement is associated with a high incidence of metastatic disease at time of surgery. Because the median number of involved lymph nodes is low after preoperative chemoradiotherapy, the TNM staging system may not provide an accurate assessment of metastatic disease. Therefore, the ypTNM staging system should incorporate distribution as well as number of lymph node metastases after preoperative chemoradiotherapy for rectal cancer.

APA, Harvard, Vancouver, ISO, and other styles

6

Picciotto, Franco, Gianluca Avallone, Federico Castellengo, Martina Merli, Virginia Caliendo, Rebecca Senetta, Adriana Lesca, et al. "Non-Sentinel Lymph Node Detection during Sentinel Lymph Node Biopsy in Not-Complete-Lymph-Node-Dissection Era: A New Technique for Better Staging and Treating Melanoma Patients." Journal of Clinical Medicine 10, no. 19 (September 23, 2021): 4319. http://dx.doi.org/10.3390/jcm10194319.

Full text

Abstract:

Sentinel lymph node biopsy has been demonstrated to be an effective staging procedure since its introduction in 1992. The new American Joint Committee on Cancer (AJCC) classification did not consider the lack of information that would result from the less usage of the complete lymph node dissection as for a diagnostic purpose. Thus, this makes it difficult the correct staging and would leave about 20% of the further positive non-sentinel lymph nodes in the lymph node basin. In this paper, we aim to describe a new surgical technique that, combined with single-photon emission computed tomography-computed tomography (SPECT-CT), allows for better staging of melanoma patients. This is a prospective study that includes 104 patients with cutaneous melanoma. Sentinel lymph node biopsy was offered according to the AJCC guideline. Planar lymphoscintigraphy was performed in association with SPECT-CT, identifying and removing all non-biologically “excluded” lymph nodes, guiding the surgeon’s hand in detection and removal of lymph nodes. Even if identification and removal of non-sentinel lymph nodes is unable to increase overall survival, it definitely gives better disease control in the basin. With a “classic” setting, the risk of leaving further lymph nodes out of the sentinel lymph node procedure is around 20%, thus, basically, the surgical sentinel lymph node of first and second lymph nodes would have therapeutic value and complete lymph node dissection classically performed.

APA, Harvard, Vancouver, ISO, and other styles

7

Vogt, H., R. Bares, W. Brenner, F. Grünwald, J. Kopp, C. Reiners, O. Schober, et al. "Verfahrensanweisung für die nuklear medizinische Wächter-Lymphknoten-Diagnostik." Nuklearmedizin 49, no. 04 (2010): 167–72. http://dx.doi.org/10.3413/nukmed-321.

Full text

Abstract:

SummaryThe authors present a procedure guideline for scintigraphic detection of sentinel lymph nodes in malignant melanoma and other skin tumours, in breast cancer, in head and neck cancer, and in prostate and penile carcinoma. Important goals of sentinel lymph node scintigraphy comprise reduction of the extent of surgery, lower postoperative morbidity and optimization of histopathological examination focussing on relevant lymph nodes. Sentinel lymph node scintigraphy itself does not diagnose tumorous lymph node involvement and is not indicated when lymph node metastases have been definitely diagnosed before sentinel lymph node scintigraphy. Procedures are compiled with the aim to reliably localise sentinel lymph nodes with a high detection rate typically in early tumour stages. Radiation exposure is low so that pregnancy is not a contraindication for sentinel lymph node scintigraphy. Even with high volumes of scintigraphic sentinel lymph node procedures surgeons, theatre staff and pathologists receive a radiation exposure < 1 mSv/year so that they do not require occupational radiation surveillance.

APA, Harvard, Vancouver, ISO, and other styles

8

Euscher, Elizabeth. "Pathology of sentinel lymph nodes: historical perspective and current applications in gynecologic cancer." International Journal of Gynecologic Cancer 30, no. 3 (February 19, 2020): 394–401. http://dx.doi.org/10.1136/ijgc-2019-001022.

Full text

Abstract:

Efforts to reduce surgical morbidity related to en bloc lymph node removal associated with cancer surgery led to the development of targeted lymph node sampling to identify the lymph node(s) most likely to harbor a metastasis. Through identification of one or only a few lymph nodes at highest risk, the overall number of lymph nodes removed could be markedly reduced. Submission of fewer lymph nodes affords more detailed pathologic examination than would otherwise be practical with a standard lymph node dissection. Such enhanced pathologic examination techniques (ie, ultra-staging) have contributed to increased detection of lymph node metastases, primarily by detection of low volume metastatic disease. Based on the success of sentinel lymph node mapping and ultra-staging in breast cancer and melanoma, such techniques are increasingly used for other organ systems including the gynecologic tract. This review addresses the historical aspects of sentinel lymph node evaluation and reviews current ultra-staging protocols as well as the implications associated with increased detection of low volume metastases.

APA, Harvard, Vancouver, ISO, and other styles

9

Harold, J. A., D. Uyar, J. S. Rader, E. Bishop, M. Nugent, P. Simpson, and W. H. Bradley. "Adipose-only sentinel lymph nodes: a finding during the adaptation of a sentinel lymph node mapping algorithm with indocyanine green in women with endometrial cancer." International Journal of Gynecologic Cancer 29, no. 1 (January 2019): 53–59. http://dx.doi.org/10.1136/ijgc-2018-000008.

Full text

Abstract:

ObjectiveTo identify factors that affect successful adaptation of sentinel lymph node mapping and those that lead to unintended adipose-only sentinel lymph node identification.MethodsSurgical and pathological data were prospectively collected on patients with endometrial cancer who underwent sentinel lymph node mapping with indocyanine green with or without pelvic and/or para-aortic lymph node dissection between November 2013 and April 2017. All mapping cases were performed with the robotic system. Adipose-only specimens were defined as a sentinel lymph node without a pathologically identified lymph node after ultrastaging.ResultsA total of 202 patients were included: 83% had endometrioid pathology, 12% serous, 3% carcinosarcoma, and 2% clear cell, with mixed pathology noted in 2%. The bilateral sentinel lymph node detection rate was 66%, and the rate of mapping at least a unilateral sentinel lymph node was 86%. Neither the bilateral nor the unilateral sentinel lymph node mapping rate changed with increased surgeon experience. The rate of adipose-only sentinel lymph node identification was more frequent when comparing the first 10 cases (37%), cases 11 – 30 (28%), and > 30 cases (9%) (P = 0.006). Body mass index > 30 kg/m2, uterine fibroids, The International Federation of Gynecology and Obstetrics (FIGO) grade, and histology were not found to have a statistically significant impact on either sentinel lymph node identification or adipose-only sentinel lymph node identification. Adipose-only sentinel lymph nodes were more likely with increased time from cervical injection to identification of the sentinel lymph node in the right hemipelvis. The median range was 28 min (14–73) for true sentinel lymph node identification vs 33 min (23–74) for adipose-only sentinel lymph node identification (P = 0.02).ConclusionPatient and surgeon factors did not impact the identification of sentinel lymph nodes over time. Adipose-only sentinel lymph nodes were more frequently identified in the initial cases and represent a potential complication to adapting sentinel lymph node biopsy without lymphadenectomy. The increase in adipose-only sentinel lymph node identification that was associated with time from cervical injection may represent delayed or disrupted uptake of indocyanine green.

APA, Harvard, Vancouver, ISO, and other styles

10

Vrancken Peeters, Marie-Jeanne TFD, Marieke Evelien Straver, Mila Donker, Claudette Loo, Gabe S. Sonke, Jelle Wesseling, and Emiel J. Rutgers. "Novel surgical technique to selectively remove metastatic axillary lymph nodes in breast cancer patients after neoadjuvant chemotherapy: The MARI procedure—Marking of the axilla with radioactive iodine seeds." Journal of Clinical Oncology 30, no. 27_suppl (September 20, 2012): 196. http://dx.doi.org/10.1200/jco.2012.30.27_suppl.196.

Full text

Abstract:

196 Background: An important benefit of neoadjuvant chemotherapy (NAC) is the increase in breast-conserving surgery. At present the response of axillary lymph node metastases to chemotherapy cannot be accurately assessed. Therefore axilla-conserving therapy is not yet a benefit. We aimed to assess a new surgical method to evaluate the axillary response: the MARI procedure, which stands for Marking of the Axillary lymph node with Radioactive Iodine seeds. Methods: Prior to NAC, proven tumor-positive axillary lymph nodes were marked with a Iodine-125 seed. After NAC, the marked lymph node was selectively removed with the use of a gamma-detection probe. A complementary axillary lymph node dissection was performed to assess whether pathological response in the marked node was indicative for the pathological response in the additional lymph nodes. Results: Tumor-positive axillary lymph nodes were successfully marked with Iodine-125 seeds in 68 patients. The marked lymph node (MARI-node) was surgically detected and selectively removed after NAC in all patients. The pathological response to chemotherapy in the MARI-node was indicative for the overall response in the additionally removed lymph nodes. In 47 patients the MARI-node contained residual disease (n=45 macrometastasis, n= 2 ITC). Thirty-five of them had macro- or micro metastases in the complementary axillary lymph node dissection specimen. In 21 patients the MARI-node was tumor negative. In 2 patients a macro metastasis was found in the additionally removed nodes, in 2 patients ITC were found and in the remaining 17 patients no residual tumor was found in the additionaly removed lymphnodes. (false negative rate of the MARI procedure: 9.5%). Conclusions: This study shows that marking and selectively removing metastatic lymph nodes after NAC is feasible. The tumor-response in the marked lymph node may be used to tailor further axillary treatment, and herewith enabling axilla-conserving surgery after neoadjuvant chemotherapy.

APA, Harvard, Vancouver, ISO, and other styles

More sources

Dissertations / Theses on the topic "Lymph node"

1

Shubitz, Lisa. "Coccidioides Lymph Node Histopathology." The University of Arizona, 2016. http://hdl.handle.net/10150/620043.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

White, Andrea Jane. "Mechanisms regulating lymph node organogenesis." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487169.

Full text

Abstract:

The fonnation of organised microenvironments within lymph nodes(LN) occurs during development and is essential to support effective immune responses. Organogenesis ofLNs requires interactions between LTI* expressing mesenchymal stromal organiser cells and LTaJI32 expressing hematopoietic LTi cells. This activates the NF-KB signalling pathway, inducing expression of chemokines and adhesion molecules that are essential for the continued recruitment and retention ofLTi cells, and ultimately the recruitment oflymphocytes to the iLN. However the cellular and molecular mechanisms ofLN development are still unclear. This study has developed novel techniques to study iLN development, including the isolation ofiLN from embryos, the generation of LTi cells in vitro, and the reaggregation and transplantation ofdifferent cellular subsets to study their interactions in vivo. We have identified a programme ofstromal cell development, related this to the role of LTi cells in iLN organogenesis and identified LT independent and LT dependent phases ofiLN development. Finally a potential precursor/product relationship between fetal LTi cells and adult CD4+CD3- cells has also been highlighted as a result ofphenotypic analysis and precursor-product relationships. To conclude, this thesis contains a detailed study into the cellular requirements and molecular mechanisms involved in iLN organogenesis.

APA, Harvard, Vancouver, ISO, and other styles

3

Kelder, Wendy. "Lymph node staging in colon cancer." [S.l. : Groningen : s.n. ; University Library of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/305609017.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Woolgar, Julia Anne. "Lymph node metastasis in oral cancer." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260368.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

LeBedis, Christina. "Lymph node involvement in breast carcinoma metastasis." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31255.

Full text

Abstract:

Since lymph node stromal cells remain largely uncharacterized with respect to cell surface markers and function, their role in regulating the growth and invasion of disseminated cancer cells, including breast carcinoma has, to date, been virtually unexplored. In the present study, we asked whether peripheral lymph node cells could modulate the growth of breast carcinoma cells and, thereby, contribute to the progression of the metastatic process. Primary cultures of rat peripheral lymph node stromal cells were obtained by limiting dilution and two sublines, STA4 and STB12, with breast carcinoma growth-promoting activities were isolated. Immunocytochemistry performed on these cells revealed that they express vimentin, S-100 and fibronectin, but neither cytokeratin nor von Willebrand factor indicating that they are stromal and dendritic in origin. Several functional studies were performed using media conditioned by STA4 and STB12 cells. (Abstract shortened by UMI.)

APA, Harvard, Vancouver, ISO, and other styles

6

Cronin, Laura. "The chronic lymphocytic leukaemia lymph node microenvironment." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6787/.

Full text

Abstract:

The lymph node (LN) microenvironment in Chronic Lymphocytic Leukaemia (CLL) is the main site of disease progression and maintenance. Whilst isolated components of the LN niche have been studied in vitro, to date, no comprehensive architectural overview of the microenvironment has been attempted. A more holistic view is essential in order to fully understand this disease. LN CLL cells are likely to receive a complex array of survival signals from accessory cells which drive disease and protect against conventional therapeutics. This study embarked upon establishing reliable combinations of primary and secondary antibodies that permit multicolour immunohistochemistry (IHC) interrogation of the CLL LN in formalin fixed paraffin embedded samples (FFPE). This work serves to demonstrate that the architecture of the CLL microenvironment is complex, dynamic and heterogeneous and highlights the advantages multicolour IHC can present to the field for understanding the therapeutic opportunities in this disease.

APA, Harvard, Vancouver, ISO, and other styles

7

Sahalan, Mariaulpa. "Diffusion-weighted Imaging of Lymph Node Tissue." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20070.

Full text

Abstract:

Purpose: The study investigates the hypothesis of clinically observed decreased apparent diffusion coefficient (ADC) of cancerous lymph nodes can be attributed to increased cellularity. The study characterises the mean diffusivity (MD) of lymph node sub-structures and investigates correlation between MD and cellularity metrics. The study also investigates the theoretical information content of single and multi-biophysical models. Methods:. A 3 mm diameter core sample was extracted from a formalin fixed lymph node tissue post-surgery and imaged using 9.4T and 16.4T Bruker MRI system. Samples were sectioned and stained with haematoxylin and eosin (H&E). Diffusion tensor model was fitted voxelwise and MD values were computed using Matlab. Cellularity metrics includes measurement of nuclear count and nuclear area. Eleven models with combinations of isotropic, anisotropic, and restricted components were tested for diffusion modelling and ranked using the Akaike information criterion (AIC). Results: The findings showed distinct diffusivities of lymph node sub-structures (capsule and parenchyma). Parenchyma in normal lymph node tissues had higher MD (0.71 ± 0.17 µm2/ms) than metastatic parenchyma (0.52 ± 0.08 µm2/ms) and lymphoma (0.47 ± 0.19 µm2/ms). No correlation were observed between MD and nuclear count (r = 0.368) and nuclear area (r = 0.368) respectively at 95 % confidence intervals. The single biophysical models (ADC and DTI) were ranked lowest by AIC. Multi-biophysical models consist of anisotropic and restricted diffusion (Zeppelin-sphere, Ball-stick-sphere, and Ball-sphere) were ranked highest in the majority of voxels of the tissue samples. Conclusion: A distinct diffusivity value were found in lymph node sub-structures with no correlation to cellularity. Multi-biophysical models were ranked highest and extract more information from the measurement data than simple single biophysical models.

APA, Harvard, Vancouver, ISO, and other styles

8

Newman, Lisa. "Intranasal infection with streptococcus pneumoniae induces pericyte relaxation and subsequent lymph node hypertrophy in the lung draining lymph node." Thesis, University of York, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516369.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Malhotra, Deepali. "Insights into the Transcriptional Identities of Lymph Node Stromal Cell Subsets Isolated from Resting and Inflamed Lymph Nodes." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10678.

Full text

Abstract:

Non-hematopoietic stromal cells (SCs) promote and regulate adaptive immunity through numerous direct and indirect mechanisms. SCs construct and support the secondary lymphoid organs (SLOs) in which lymphocytes crawl on stromal networks and inspect antigen-presenting cells for surface-display of cognate antigens. SCs also secrete survival factors and chemotactic cues that recruit, organize, and facilitate interactions among these leukocytes. They influence antigen access by secreting and ensheathing extracellular matrix-based conduit networks that rapidly convey small, soluble lymph-borne molecules to the SLO core. Furthermore, lymph node stromal cells (LNSCs) directly induce \(CD8^+\) T cell tolerance to peripheral tissue restricted antigens and constrain the proliferation of newly activated T cells in these sites. Thus, stromal-hematopoietic interactions are crucial for the normal functioning of the immune system. LNSCs are extremely rare and difficult to isolate, hampering the thorough study of their biology. In order to better understand these stromal subsets, we sorted fibroblastic reticular cells (FRCs), lymphatic endothelial cells, blood endothelial cells, and podoplanin \(^−CD31^−\) cells (double negative stromal cells; DNCs) to high purity from resting and inflamed murine lymph nodes. We meticulously analyzed the transcriptional profiles of these freshly isolated LNSCs as part of the Immunological Genome Project Consortium. Analysis of the transcriptional profiles of these LNSC subsets indicated that SCs express key immune mediators and growth factors, and provided important insights into the lymph node conduit network, FRC-specialization, and the DNC identity. Examination of hematopoietic and stromal transcription of ligands and cognate receptors suggested complex crosstalk among these populations. Interestingly, FRCs dominated cytokine and chemokine transcription among LNSCs, and were also enriched for higher expression of these genes when compared with skin and thymic fibroblasts, consistent with FRC-specialization. LNSCs that were isolated from inflamed lymph nodes robustly upregulated expression of genes encoding cytokines, chemokines, antigen-processing and presentation machinery, and acute-phase response molecules. Little-explored DNCs showed many transcriptional similarities to FRCs, but importantly did not transcribe interleukin-7. We identified DNCs as consisting largely of myofibroblastic pericytes that express integrin \(\alpha 7\). Together these data comprehensively describe the transcriptional characteristics of four major LNSC subsets isolated from resting and inflamed SLOs, offering many avenues for future study.

APA, Harvard, Vancouver, ISO, and other styles

10

Woodruff, Matthew Charles. "Structure and Function of the Murine Lymph Node." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13102331.

Full text

Abstract:

Lymph nodes (LNs) are dynamic organs responsible for providing a supportive and centralized environment for the generation of immune response. Utilizing a highly organized network of non-hematopoietic stromal cells, the LN serves as the context in which the immune system collects and presents antigen, promotes innate and adaptive immune interaction, and generates protective cell-mediated and humoral immunity. In this way, proper organization and function of the LN environment is a critical component of effective immunity, and understanding its complexity has direct impact on the ability to generate and modulate primary immune response to specific antigens. To this end, the LN architecture, underlying stromal networks, and environmental and cellular responses to influenza vaccination were investigated. Using novel approaches to conduit imaging, details of the collagen network that comprises the LN scaffolding have been integrated into current understandings of LN architecture. The cellular compartment responsible for the maintenance of that scaffolding, fibroblastic reticular cells (FRCs), have been studied using an induced diptheria toxin receptor model. By specifically ablating the FRC population in mice, their role in the maintenance of T cell homeostasis has been confirmed in vivo. More surprisingly, a disruption of the FRC network resulted in a loss of B cell follicle structure within LNs, and a reduction in humoral immunity to influenza vaccination. These findings led to the identification of a new subset of FRCs which reside in B cell follicles, and serve as a critical source of the B cell survival factor BAFF. Turning towards the hematopoietic response to influenza vaccination, a highly unexpected lymph node resident dendritic cell (LNDC) response has been identified following vaccine antigen deposition within specialized sites in the LN medulla. Rapid migration of LNDCs into these sites optimizes exposure of the population to viral antigen, and de novo synthesis of a CXCL10 chemokine gradient by activated LNDCs ensures efficient antigen specific \(CD4^+\) T cell response, and protective humoral immunity - independent of migratory dendritic cell status. Altogether, these studies highlight a highly dynamic, responsive LN environment with direct influence on primary immune response - the understanding of which has broad implications in vaccine biology.

APA, Harvard, Vancouver, ISO, and other styles

More sources

Books on the topic "Lymph node"

1

Ioachim, Harry L. Lymph node pathology. 2nd ed. Philadelphia: J.B. Lipincott Co., 1993.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

2

Pambuccian, Stefan E., and Ricardo H. Bardales. Lymph Node Cytopathology. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-6964-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Addis, B. J. (Bruce J.) and Leong, Anthony S. -Y. (Anthony Siew-Yin), 1945-, eds. Diagnostic lymph node pathology. 2nd ed. London: Hodder Arnold, 2011.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

4

Richter, Eckart, and Thomas Feyerabend. Normal Lymph Node Topography. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-58193-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Harisinghani, Mukesh G., ed. Atlas of Lymph Node Anatomy. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-80899-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Miranda, Roberto N., Joseph D. Khoury, and L. Jeffrey Medeiros. Atlas of Lymph Node Pathology. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7959-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Harisinghani, Mukesh G., ed. Atlas of Lymph Node Anatomy. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9767-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Nasr, Michel R., Anamarija M. Perry, and Pamela Skrabek. Lymph Node Pathology for Clinicians. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11515-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Diagnostic histopathology of the lymph node. New York: Oxford University Press, 1998.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

10

Richter, E. Normal lymph node topography: CT atlas. Berlin: Springer, 2004.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

More sources

Book chapters on the topic "Lymph node"

1

Remstein, Ellen D., and Paul J. Kurtin. "Lymph Node." In Essentials of Anatomic Pathology, 423–65. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1007/978-1-60327-173-8_9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

van den Brand, Michiel. "Lymph Node." In Encyclopedia of Pathology, 292–99. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-95309-0_3860.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

McPhail, Ellen D., and Paul J. Kurtin. "Lymph Node." In Essentials of Anatomic Pathology, 751–89. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-23380-2_15.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

van den Brand, Michiel. "Lymph node." In Encyclopedia of Pathology, 1–8. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-28845-1_3860-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Elmore, Susan A., and Schantel A. Bouknight. "Lymph Node." In Immunopathology in Toxicology and Drug Development, 59–79. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-47385-7_3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

McPhail, Ellen D., and Paul J. Kurtin. "Lymph Node." In Essentials of Anatomic Pathology, 681–721. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6043-6_15.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Zhang, Xiaohong, and Nadine S. Aguilera. "Lymph Node." In Handbook of Practical Immunohistochemistry, 591–628. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-1578-1_30.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Gooch, Jan W. "Lymph Node." In Encyclopedic Dictionary of Polymers, 905. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_14152.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Cai, Guoping. "Lymph Node." In Rapid On-site Evaluation (ROSE), 119–50. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-21799-0_6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Zhang, Xiaohong Mary, and Yi Ding. "Lymph Node." In Handbook of Practical Immunohistochemistry, 751–98. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-83328-2_31.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Lymph node"

1

Yang, Chun-Lin, Nandan Shettigar, and C. Steve Suh. "A Proposition for Describing Real-World Network Dynamics." In ASME 2021 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/imece2021-73360.

Full text

Abstract:

Abstract This study presents a proposition for describing the dynamics of real-world networks under the general framework of complex networks. Outward behaviors of complex networks are the manifestation of the coupled dynamics at the macroscopic level and the individual dynamics at the microscopic level. At the macroscopic level a law of coupling governs the interactions of network constituents. At the microscopic level, the dynamics of individual constituent is defined by energy that follows normal distribution. Constituent dynamics are bounded by physical constraints. Consequently, network dynamics can be quantified using information entropy which is a function of constituent energy. In real-world networks, differences between individual constituents exist due to differing mechanical properties and dynamics. Consequently, network dynamics are of different layers and hierarchies. Construct of network governing equations formulated under the general framework of complex networks are demonstrated using two real-world networks — a brain network and a lymph node network. Brain network is constructed by the neurons that each connected by the synapse. Brain network dynamics is composed by the law of coupling defined by the synaptic dynamics through the transmitting of neurotransmitters that couples the individual neuron dynamics. Since different classifications exist among neurotransmitters and neurons, the post synaptic neuron can present either inhibitory or excitatory action. The inhibitory and excitatory behavior of the neurons changes the mechanical properties of each neuron and further alters the brain network dynamics. Consequently, the brain network emerges dynamics with different layers. Lymph node network drains fluid from blood vessels, filter the lymph (the interstitial fluid lymphatic system collects from the blood circulation) through lymph nodes, and transport the lymph back to the blood circulation. Lymph node dynamics is composed by the dynamics of lymph transportation along the lymph node network and the individual lymph node dynamics that involves lymphocytes-pathogens interactions (adaptive immune response). In each lymph node, lymphocytes fight off the pathogens which also emerges a network dynamics such as the interaction between T cells and HIV viruses. Finally, the lymph is collected from each lymph nodes and drained back to the blood circulation. As a result, the lymph node network has the dynamics of different hierarchies where the lymphocytes-pathogens dynamics exists within each lymph node at the lower hierarchy is further under the influence of the lymph transportation dynamics among the whole lymph node network on the higher hierarchy. Since the constituent dynamics of the brain network and lymph node network can be defined by energy that follows normal distribution and both are bounded by physical constraints, the network dynamics of both cases can be quantified through information entropy. Features pertaining to the global as well as individual constituent dynamics of the networks are identified that are insightful to the control of such complex networks.

APA, Harvard, Vancouver, ISO, and other styles

2

Irakleidis, Foivos, Ashutosh Tondare, Hisham Hamed, and Ashutosh Kothari. "MANAGEMENT OF THE AXILLA IN PATIENTS WITH BREAST CANCER AND ONE OUT OF ONE POSITIVE SENTINEL LYMPH NODE. CAN WE OMIT AXILLARY LYMPH NODE CLEARANCE?" In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2063.

Full text

Abstract:

Background: Over the past three decades, the treatment of the axilla in breast cancer management continues to change. Current treatment strategies aim to achieve regional nodal control associated with reduced incidence of lymphedema and other long-term complications. In this study, we analyzed our tertiary center’s database of patients who had a single retrieved sentinel node (SN) that was positive for macrometastatic disease. We focused on AMAROS trial outcomes and the future view of treating this cohort of patients with axillary radiotherapy (RT) instead of axillary node clearance (ANC). Methods: Both the literature review and the 5-year retrospective analysis of our database were performed, focusing on the management of the axilla in patients with breast cancer with one-in-one positive SN. Results: A total of 24 patients who had surgery as primary treatment had one-in-one positive SN. All patients had the clinical and radiological assessment of their axilla prior to their sentinel lymph node biopsy (SNB). In all, 92% of these patients had a complete ANC, 50% of them had zero additional positive nodes, 21% had only one additional positive node, and a further 21% had more than one additional positive node. One patient was planned for ANC but died from chemotherapy-related complications and one more patient had alternative axillary RT instead of ANC. Of note, 80% of patients who had three or more positive axillary lymph nodes following ANC had indeed evidence of advanced locoregional disease and thus would not be eligible for alternative axillary RT, as compared with one patient who had a multifocal disease, could have axillary RT but had a heavy axillary burden on ANC. Finally, 71% of patients could have been offered alternative axillary RT but had ANC instead. Fourteen patients from this group had chest wall and supraclavicular fossa RT after their initial surgery, and thus, the addition of axillary RT instead of ANC could have been offered. Conclusion: In patients with early breast cancer and clinically node-negative axilla, disease burden in non-SN is limited and ANC may entail overtreatment. In view of low recurrence and complication rates seen in the AMAROS trial, axillary irradiation appears to be a valid and safe alternative when compared with ANC in patients with one-in-one positive SN.

APA, Harvard, Vancouver, ISO, and other styles

3

Pappa, C., S. Smith, HJ Jiang, and M. Alazzam. "1115 Inguinofemoral lymph node dissection technique." In ESGO 2021 Congress. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/ijgc-2021-esgo.637.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Honea, David M., Yaorong Ge, Wesley E. Snyder, Paul F. Hemler, and David J. Vining. "Lymph node segmentation using active contours." In Medical Imaging 1997, edited by Kenneth M. Hanson. SPIE, 1997. http://dx.doi.org/10.1117/12.274116.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Kwon, Sunkuk, and Eva M. Sevick-Muraca. "Changes in lymph node metastasis patterns after surgical removal of a popliteal lymph node in mice." In Optical Tomography and Spectroscopy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/ots.2016.ptu3a.1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Kwon, Sunkuk, and Eva M. Sevick-Muraca. "Changes in lymph node metastasis patterns after surgical removal of a popliteal lymph node in mice." In Clinical and Translational Biophotonics. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/translational.2016.ptu3a.1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Bushhouse, David Z., and Kristian M. Hargadon. "Abstract 159: Chemokine receptor expression profiling of lymph node invasive versus lymph node non-invasive melanomas." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-159.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Bushhouse, David Z., and Kristian M. Hargadon. "Abstract 159: Chemokine receptor expression profiling of lymph node invasive versus lymph node non-invasive melanomas." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-159.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Kwon, Sunkuk, and Eva M. Sevick-Muraca. "Changes in lymph node metastasis patterns after surgical removal of a popliteal lymph node in mice." In Optics and the Brain. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/brain.2016.ptu3a.1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Kwon, Sunkuk, and Eva M. Sevick-Muraca. "Changes in lymph node metastasis patterns after surgical removal of a popliteal lymph node in mice." In Cancer Imaging and Therapy. Washington, D.C.: OSA, 2016. http://dx.doi.org/10.1364/cancer.2016.ptu3a.1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Lymph node"

1

Sutton, Richard. Sentinel Lymph Node Biopsy. Touch Surgery Simulations, October 2014. http://dx.doi.org/10.18556/touchsurgery/2014.s0033.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Park, Serk I. Role of c-Src Activation on Prostate Cancer Lymph Node Metastases. Fort Belvoir, VA: Defense Technical Information Center, October 2008. http://dx.doi.org/10.21236/ada493721.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Goodwin, Andrew P. Multifunctional Polymer Microbubbles for Advanced Sentinel Lymph Node Imaging and Mapping. Fort Belvoir, VA: Defense Technical Information Center, June 2012. http://dx.doi.org/10.21236/ada583372.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Goodwin, Andrew P. Multifunctional Polymer Microbubbles for Advanced Sentinel Lymph Node Imaging and Mapping. Fort Belvoir, VA: Defense Technical Information Center, March 2012. http://dx.doi.org/10.21236/ada591061.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Deng, Chun, Zhenyu Zhang, Zhi Guo, Hengduo Qi, Yang Liu, Haimin Xiao, and Xiaojun Li. Assessment of intraoperative use of indocyanine green fluorescence imaging on the number of lymph node dissection during minimally invasive gastrectomy: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2021. http://dx.doi.org/10.37766/inplasy2021.11.0062.

Full text

Abstract:

Review question / Objective: Whether is indocyanine green fluorescence imaging-guided lymphadenectomy feasible to improve the number of lymph node dissections during radical gastrectomy in patients with gastric cancer undergoing curative resection? Condition being studied: Gastric cancer was the sixth most common malignant tumor and the fourth leading cause of cancer-related death in the world. Radical lymphadenectomy was a standard procedure in radical gastrectomy for gastric cancer. The retrieval of more lymph nodes was beneficial for improving the accuracy of tumor staging and the long-term survival of patients with gastric cancer. Indocyanine green(ICG) near-infrared fluorescent imaging has been found to provide surgeons with effective visualization of the lymphatic anatomy. As a new surgical navigation technique, ICG near-infrared fluorescent imaging was a hot spot and had already demonstrated promising results in the localization of lymph nodes during surgery in patients with breast cancer, non–small cell lung cancer, and gastric cancer. In addition, ICG had increasingly been reported in the localization of tumor, lymph node dissection, and the evaluation of anastomotic blood supply during radical gastrectomy for gastric cancer. However, it remained unclear whether ICG fluorescence imaging would assist surgeons in performing safe and sufficient lymphadenectomy.

APA, Harvard, Vancouver, ISO, and other styles

6

Ying, Hongan, Jinfan Shao, Xijuan Xu, Wenfeng Yu, and Weiwen Hong. Perineural Invasion is an Indication of Adjuvant Chemotherapy in Node Negative Colorectal cancer. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2021. http://dx.doi.org/10.37766/inplasy2021.12.0103.

Full text

Abstract:

Review question / Objective: Perineural invasion (PNI) is a possible route for metastatic spread in various cancer types, including colorectal cancer (CRC). PNI is linked to poor prognosis. For patients with lymph node positive colorectal cancer, a number of large-scale RCT studies have confirmed that they can benefit from chemotherapy, but there are still many controversies about whether colorectal patients with negative lymph nodes need adjuvant chemotherapy. At present, there is a general consensus that patients with stage II colorectal cancer who have risk factors such as PNI+ need chemotherapy. However, there are many recent literatures that show that patients with stage II colorectal cancer with nerve invasion risk factors can not prolong the OS and DFS of patients. At the same time, chemotherapy increases the toxicity, economic and mental burden of patients. Therefore, we hope to write this review to summarize the current research findings and provide some clinical guidance on whether patients with lymph node negative colon cancer who have perineural invasion should receive chemotherapy. Condition being studied: Patients with high-risk such as PNI+ stage II colon cancer (CC) are recommended to undergo adjuvant chemotherapy (ACT). However, whether such patients can benefit from ACT remains unclear. And recently studies shown that, ACT had no significant benefit among patients with PNI.

APA, Harvard, Vancouver, ISO, and other styles

7

Hassett, Mary. Outcomes by Ethnicity: Sentinel Lymph Node Status in Women with Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, April 2007. http://dx.doi.org/10.21236/ada495304.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Cavalli, Luciane R. Detection of Genetic Alterations in Breast Sentinel Lymph Node by Array-CGH. Fort Belvoir, VA: Defense Technical Information Center, October 2005. http://dx.doi.org/10.21236/ada444833.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Cavalli, Luciane R. Detection of Genetic Alterations in Breast Sentinel Lymph Node by Array-CGH. Fort Belvoir, VA: Defense Technical Information Center, October 2006. http://dx.doi.org/10.21236/ada460808.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Datta, Kaustubh. Elucidation of the Molecular Mechanism Underlying Lymph Node Metastasis in Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2006. http://dx.doi.org/10.21236/ada469826.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!