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Academic literature on the topic 'Lyme, Maladie de – imagerie diagnostique'
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Journal articles on the topic "Lyme, Maladie de – imagerie diagnostique"
Dalmat, Yann-Mickael. "Bréve : Maladie de Lyme : errance diagnostique ?" Option/Bio 31, no. 615-616 (May 2020): 10. http://dx.doi.org/10.1016/s0992-5945(20)30109-4.
Full textPiednoir, E. "Maladie de Lyme : modélisation du risque d’erreur diagnostique en pratique courante." Médecine et Maladies Infectieuses 50, no. 6 (September 2020): S108. http://dx.doi.org/10.1016/j.medmal.2020.06.221.
Full textForestier, E., F. Gonnet, A. Revil-Signorat, and A. C. Zipper. "Cheminement diagnostique et vécu des patients se pensant atteints de « maladie de Lyme chronique »." La Revue de Médecine Interne 39, no. 12 (December 2018): 912–17. http://dx.doi.org/10.1016/j.revmed.2018.04.002.
Full textSégard-Weisse, Émilie, Bianca Drumond, Thomas-Cancian Aurélie, and Schramme Michael. "IRM bas champ debout du pied chez le cheval de sport : bilan de deux décennies d’examens." Le Nouveau Praticien Vétérinaire équine 17-18, no. 61-62 (2023): 70–88. http://dx.doi.org/10.1051/npvequi/2024031.
Full textHenry, C. "Le trouble bipolaire et ses biomarqueurs : quoi de neuf ?" European Psychiatry 29, S3 (November 2014): 557. http://dx.doi.org/10.1016/j.eurpsy.2014.09.364.
Full textGARNIER, C., B. BASTIAN, H. COLINEAUX, JB CATHELAIN, M. ESVAN, A. CHAPRON, PE BIGOTTE, and P. LE DOUARON. "DYSTHIROIDIE EN FRANCE : EVALUATION DES PRATIQUES DIAGNOSTIQUES DES MEDECINS GENERALISTES." EXERCER 35, no. 204 (June 1, 2024): 260–67. http://dx.doi.org/10.56746/exercer.2024.204.260.
Full textDupuis-Tricaud, Marie-Capucine, and Marianne Depecker. "La maladie de Lyme chez le cheval : un défi clinique et diagnostique." Bulletin de l'Académie Vétérinaire de France, no. 3 (2019). http://dx.doi.org/10.4267/2042/70201.
Full textAdmin - JAIM. "Résumés des conférences JRANF 2021." Journal Africain d'Imagerie Médicale (J Afr Imag Méd). Journal Officiel de la Société de Radiologie d’Afrique Noire Francophone (SRANF). 13, no. 3 (November 17, 2021). http://dx.doi.org/10.55715/jaim.v13i3.240.
Full textDissertations / Theses on the topic "Lyme, Maladie de – imagerie diagnostique"
Toska, Antonia. "Development of a new analytical approach for the diagnosis of Lyme disease." Electronic Thesis or Diss., Pau, 2024. http://www.theses.fr/2024PAUU3081.
Full textThe diagnosis of Lyme disease, caused by tick-borne Borrelia bacteria, is difficult due to their low concentration in clinical samples, as well as the existence of several pathogenic species. The recommended diagnostic method is an indirect serological approach, which is associated with the risk of both false-positive and false-negative results. The aim of this PhD work was to develop a methodological proof-of-concept for the ultra-sensitive and highly specific detection of Borrelia burgdorferi using functionalized nanoparticles and inductively coupled plasma mass spectrometry (ICP-MS) analysis. Nanoparticle synthesis and functionalization were carried out and optimized using surface analysis techniques such as XPS and Auger spectroscopy. Several analytical routes were followed, based on the use of different particle types combined with a panel of ICP-MS experimental conditions enabling significant specificity and sensitivity for Borrelia burgdorferi from buffer solutions or artificial blood samples used as model blood matrix
Vannetzel, Daniel. "Les rhombencéphalites aiguës et subaiguës : approche diagnostique et thérapeutique : à propos de quinze observations." Bordeaux 2, 1989. http://www.theses.fr/1989BOR25057.
Full textCarey, Guillaume. "Imaging anxiety in Parkinson's disease." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. https://pepite-depot.univ-lille.fr/ToutIDP/EDBSL/2024/2024ULILS023.pdf.
Full textAnxiety in Parkinson's disease (PD) is a frequent and disabilitating non-motor symptom. It is difficult to manage, partly due to a poor knowledge of the underlying mechanisms. The objective of this thesis was to identify the underlying mechanisms of PD-related anxiety, using multimodal brain MRI.A systematic review of the literature on imaging data in PD-related anxiety was first carried out, allowing the generation of initial hypotheses. Then, several studies including structural and functional brain MRI analyses were carried out in PD patients with or without clinically significant anxiety. Our analyses focused on the fear circuit, known to be involved in anxiety disorders and fear processing, and the limbic cortico-striato-thalamo-cortical circuit, known for its involvement in the neuropsychiatric symptoms of PD.Our results suggest that PD-related anxiety is the consequence of a functional and structural imbalance between these two circuits. Certain overlapping structures, such as the thalamus, the striatum or the brainstem nuclei, could be key areas whose alteration could explain the high prevalence of these disorders in PD. Further works based in particular on technological advances in imaging and new concepts concerning the pathophysiology of PD will be necessary to answer the remaining questions
Coatnoan, Nicolas. "La Trypanosoma cruzi proline racemase, un marqueur diagnostique et de suivi pour la Maladie de Chagas ?" Electronic Thesis or Diss., Sorbonne université, 2018. http://www.theses.fr/2018SORUS315.
Full textChagas disease caused by Trypanosoma cruzi occurs in Latin and Central America. The parasite is difficult to detect outside the acute phase of infection. No diagnostic means is 100% reliable and does not allow detection of the parasite in the tissues and no vaccine is available. The laboratory characterized the first eukaryotic proline racemase which is also a mitogen for B cells: Trypanosoma cruzi proline racemase (TcPRAC). It is a virulence factor for the parasite, essential for its survival. TcPRAC genes are present in all genotypes of the parasite and are absent in other infectious trypanosomatids. TcPRAC could be a specific marker for the disease. We have demonstrated, using the experimental model, that TcPRAC is indeed a specific diagnostic marker of the infection but especially a marker that would make it possible to assert the effectiveness of a treatment. We were able to follow the infectious process in real time by in vivo imaging. We have produced anti-TcPRAC VHHs capable of binding to intracellular TcPRAC expressed by live parasites in vitro. We have initiated the development of a prototype for the detection of intracellular parasites in vivo. We have been able to optimize new trypanocidal compounds in order to develop new chemotherapies against the disease
Quinlivan, Mitchell. "Rôles du système cholinergique dans le disfonctionnement cognitif associé à la maladie Alzheimer et évaluation d'outils pour l'imagerie moléculaire." Tours, 2007. http://www.theses.fr/2007TOUR3324.
Full textCholinergic neuron degeneration is a prominent hallmark of Alzheimer’s disease (AD). Using a specific immunotoxin (SAP), basal forebrain cholinergic neurons in the rat were lesioned, as assessed by immunohistochemistry (IHC), to model this facet of AD. Behavioural testing, utilising models with two different routes of SAP administration, further demonstrated the necessity of this system for normal attentional function and its relatively minor role in mnemonic function, cognitive domains greatly affected by AD. Studies with radioligands specific for the nicotinic receptor (nAChR) or the Vesicular Acetylcholine Transporter were both able to demonstrate the lesion validated by IHC, the first time a nAChR radioligand has done this in a SAP model. Although eventually it was unable to be used for the in vivo continuation of this work, studies for the development of a small-animal molecular imaging system initially intended for such a continuation are also reported
Artero, Sylvaine. "Détection des troubles cognitifs légers (MCI) : algorithmes diagnostiques, dépistage et validité prédictive." Montpellier 1, 2004. http://www.theses.fr/2004MON1T004.
Full textHett, Kilian. "Multi-scale and multimodal imaging biomarkers for the early detection of Alzheimer’s disease." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0011/document.
Full textAlzheimer’s disease (AD) is the most common dementia leading to a neurodegenerative process and causing mental dysfunctions. According to the world health organization, the number of patients having AD will double in 20 years. Neuroimaging studies performed on AD patients revealed that structural brain alterations are advanced when the diagnosis is established. Indeed, the clinical symptoms of AD are preceded by brain changes. This stresses the need to develop new biomarkers to detect the first stages of the disease. The development of such biomarkers can make easier the design of clinical trials and therefore accelerate the development of new therapies. Over the past decades, the improvement of magnetic resonance imaging (MRI) has led to the development of new imaging biomarkers. Such biomarkers demonstrated their relevance for computer-aided diagnosis but have shown limited performances for AD prognosis. Recently, advanced biomarkers were proposed toimprove computer-aided prognosis. Among them, patch-based grading methods demonstrated competitive results to detect subtle modifications at the earliest stages of AD. Such methods have shown their ability to predict AD several years before the conversion to dementia. For these reasons, we have had a particular interest in patch-based grading methods. First, we studied patch-based grading methods for different anatomical scales (i.e., whole brain, hippocampus, and hippocampal subfields). We adapted patch-based grading method to different MRI modalities (i.e., anatomical MRI and diffusion-weighted MRI) and developed an adaptive fusion scheme. Then, we showed that patch comparisons are improved with the use of multi-directional derivative features. Finally, we proposed a new method based on a graph modeling that enables to combine information from inter-subjects’ similarities and intra-subjects’ variability. The conducted experiments demonstrate that our proposed method enable an improvement of AD detection and prediction
Puy, Laurent. "Mécanismes et Conséquences de l’Oedème Cérébral sur le Pronostic des Hémorragies IntraCérébrales Spontanées." Thesis, Université de Lille (2018-2021), 2021. http://www.theses.fr/2021LILUS058.
Full textSpontaneous intracerebral haemorrhage (ICH) is associated with a dramatic prognosis and remains devoid of specific treatment. Therefore, understanding the mechanisms of ICH pathology and repair is a matter of high priority. The peri-haemorrhagic zone, commonly called "peri-haematomal oedema" (PHE), might be a promising candidate for therapeutic interventions. However, its underlying mechanisms, natural evolution and prognostic value remain to date unclear. This thesis aimed at studying the mechanisms and consequences of this PHE. To do so, we combined an experimental (animal model of ICH) and a neuropathological (post-mortem study on human tissue) approach.We used the double autologous blood injection model to reproduce ICH in a large cohort of male and female rats. In a first study, we showed how multimodal MRI is a reliable tool to track the dynamic progression of peri-haematomal injuries and we characterized the kinetics of different PHE components (water content, [micro]-vessel injuries, neuro-inflammation and iron deposits). In a second study, we investigated the short and long-term consequences of ICH. We reported that a deep ICH provokes long term cognitive impairments in rats that affects both hippocampal and non hippocampal aspects of cognition contrasting with early spontaneous locomotor recovery. We also showed that focal striatal ICH induces distant brain atrophy and hypometabolism involving limbic system structures and cortical areas. We included 19 cases of patients who died from ICH in a post-mortem study. We provided evidence for Neutrophil extracellular Traps (NETs) infiltration within the haematoma core but also and within the PHE. We also investigated the natural kinetic of natural blood clearance process after ICH in human brain tissue with a focus on the monocyte-macrophage scavenger receptor (CD163)/hemoxygenase-1 (HO-1) pathway. Our findings contribute to refine our perception of PHE, to optimize the translational pipeline and, hopefully, to identify innovative therapeutic strategies for ICH