Dissertations / Theses on the topic 'Lung development'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'Lung development.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
Grier, D. G. "Homeobox genes in lung development." Thesis, Queen's University Belfast, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426729.
Full textCherukupalli, Kamala. "Studies on the normal and abnormal lung growth in the human and in the rat with emphasis on the connective tissue fibers of the lung." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/30607.
Full textMedicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate
Gao, Weichen. "Development of human lung query atlas." Thesis, University of Iowa, 2010. https://ir.uiowa.edu/etd/806.
Full textTiozzo, Caterina. "Role of Pten in lung development." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426411.
Full textRationale: Pten e’ un gene coinvolto nell’omeostasi delle cellule staminali e nella formazione di tumori. Nei topi, Pten inizia ad essere presente 7 giorni dopo il concepimento. Pten ha un ruolo critico nello sviluppo embrionale: gli embrioni di topo Pten-/-, infatti, muoiono molto presto durante la gestazione. Scopo dello studio: Studiare il ruolo di Pten nello sviluppo polmonare, eliminando Pten nell’epitelio polmonare, incrociando Ptenflox/flox con topi portatori di Nkx2.1-cre; Pten e’ stato anche eliminato dal mesenchima polmonare incrociando Ptenflox/flox con topi Dermo1-cre. I risultanti PtenNkx2.1cre sono stati analizzati alla ricerca di difetti nello sviluppo polmonare. Risultati: I polmoni PtenNkx2.1-cre hanno evidenziato in vitro una alterata risposta al TGF-?. In vivo non presentavano nessuna alterazione nel branching bensi una iperplasia polmonare nelle vie aerre. Nei topi adulti, I polmoni PtenNkx2.1-cre presentavano un aumentato pool di cellule progenitori in tutti i distretti: nella trachea, le cellule basali, nei bronchi le cellule neuroepiteliali, positive per CGRP/CC10 ed infine, nella giunzione tra gli alveoli e I bronchi terminali (BADJ), le cellule positive per Spc/CC10. L’assenza di Pten ha un impatto nella differenziazione cellulare, con un diminuito aumento delle cellule all’ultimo stadio di differenziazione. Nel tempo, le cellule epiteliali PtenNxk2.1-cre residenti a livello del BADJ proliferano e formano delle masse di tipo tumorale; questi dati supportano l’idea che le cellule presenti in questa niche possano essere l’origine delle cosidette “pro-carcinogenic stem cells”. L’aumento delle cellule progenitrici, inoltre, conferisce un selettivo vantaggio dopo danno polmonare. I topi con Pten eliminato nell’epitelio, invece, non evidenziavano ne uno sviluppo polmonare alterato ne una alterata differenziazione delle cellule mesenchimali; tuttavia, dimostravano un aumentata deposizione di collagene1 e di matrice extracellulare. Conclusioni: Pten ha un ruolo importante nell’omeostasi delle cellule progenitori del polmone, nella differenziazione epiteliale polmonare e nella resistenza dopo danno. Ulteriori studi sono necessary per chiarire l’esatto ruolo di Pten nel mesenchima polmonare.
Mattes, Charlott, and Ulrich H. Thome. "Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells." Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-142643.
Full textSalvati, Valentina. "Development of effective lung cancer therapies based on lung cancer stem cella targeting." Doctoral thesis, Università di Catania, 2015. http://hdl.handle.net/10761/4035.
Full textWu, Mau-Ching. "Mouse models of human lung cancer development." Thesis, University of Cambridge, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624711.
Full textNickel, Jacob. "Development of an electronic lung airway atlas." Thesis, University of Iowa, 2008. http://ir.uiowa.edu/etd/14.
Full textBonner, Allison E. "Organ development and tumorigenesis: a molecular link." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1073936508.
Full textBloor, Claire Alexandra. "Insulin-like Growth Factor-1 (IGF-1) axis : role in development of lung fibrosis." Thesis, Keele University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323715.
Full textHarding-Smith, Rebekka. "Gene transfer vector development to treat lung disease." Thesis, University of Oxford, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711729.
Full textDixit, Radhika Nagaraj. "The contribution of mesothelial cells to lung development." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12825.
Full textMesothelium-derived progenitors have been demonstrated to contribute to differentiated mesenchymal components of the heart, liver, and gut during organogenesis. The precise contribution of the mesothelium to lung development, however, has not been fully clarified and the key signals regulating mesothelial cell entry have not been identified. To rigorously address this issue, we employed mice with an inducible Cre expressed from the Wilm's tumor-1 (WT1) locus for high fidelity lineage tracing after confirming that Cre-recombinase was mesothelial-specific and faithfully recapitulated endogenous WT1 gene expression. We visualized WT1+ mesothelial cell entry into the fetal lung by live imaging and identified their progenies in subpopulations of bronchial smooth muscle cells, vascular smooth muscle cells, and desmin+ fibroblasts by lineage tagging. In view of the role of Sonic Hedgehog (Hh) signaling in regulating mesenchymal cell differentiation and epithelial-mesenchymal transition, we hypothesized that this pathway regulates events associated with migration of mesothelial cells into the developing lung. To examine for this, we first used two independent reporter mice to show that Hh signaling is active within the lung mesothelium at time points coinciding with the appearance of mesothelium-derived cells in the lung parenchyma. Using loss-of-function assays in organ cultures, and targeted mesothelial-restricted loss-of hedgehog function mice, we demonstrated that mesothelial cell movement into the lung requires the direct action of Hh signaling. In order to examine whether WT1 interacts with Hh pathway, we conducted ChIP assays on fetal lung mesothelial cells, and found that WT1 directly binds and regulates promoter elements of downstream targets of Hh pathway. Consistent with this observation, Hh pathway gene expression was down-regulated in isolated WT1 deficient fetal lung mesothelial cells. Taken together, these findings lend further support to a paradigm in which mesothelial cells are an important source of progenitors for mesenchymal structures. Our findings also reveal a role for Hh pathway in the early events associated with mesothelial cell entry and indicate that WT1 likely acts upstream of Hh signaling.
Gardner, Margaret A. B. S. "Cell and developmental stage specific role of Dicer1 in the lung epithelium." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427797752.
Full textBlachford, Karen Grace. "Effects of loss of amniotic fluid on lung growth and maturation in rat fetuses." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24482.
Full textMedicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate
McElroy, Mary Catherine. "The role of antioxidant enzymes in human lung development." Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293725.
Full textChawsheen, Hedy. "ROLE OF SULFIREDOXIN INTERACTING PROTEINS IN LUNG CANCER DEVELOPMENT." UKnowledge, 2016. http://uknowledge.uky.edu/toxicology_etds/13.
Full textWAN, HUAJING. "CRITICAL ROLES OF FORKHEAD BOX A2 DURING LUNG DEVELOPMENT." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1091650603.
Full textKulkarni, Rishikesh Manohar. "Regulation of Lymphatic Endothelial Development and Function in Lung." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1242673402.
Full textPouliot, Robert A. "DEVELOPMENT AND CHARACTERIZATION OF LUNG DERIVED EXTRACELLULAR MATRIX HYDROGELS." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4465.
Full textWang, Hui. "Development of nicotine loaded chitosan nanoparticles for lung delivery." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/108006/1/Hui_Wang_Thesis.pdf.
Full textMaas, Janet Catherine. "Development of corticosteroid liposomes for delivery to airway macrophages." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243075.
Full textLaube, Mandy, Miriam Bossmann, and Ulrich H. Thome. "Glucocorticoids distinctively modulate the CFTR channel with possible implications in lung development and transition into extrauterine life." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-169679.
Full textBerg, Tove. "C/EBP transcription factors in lung cellular differentiation and development /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-586-0/.
Full textBoland, Rochelle Elizabeth 1974. "Factors affecting structural development of the lung in fetal sheep." Monash University, Dept. of Physiology, 2002. http://arrow.monash.edu.au/hdl/1959.1/8135.
Full textXu, Li Jing. "Oxygen and lung development in newborn rats and chick embryos." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61955.
Full textBustani, Porus C. "The role of hyperoxia in abnormal development of fetal lung." Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/4567.
Full textSitaraman, Sneha. "Alveolar type 2 epithelial cells in lung development and disease." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1571062200291287.
Full textPozarska, Agnieszka [Verfasser]. "Tgfbr3 regulates alveolarisation in late lung development / Agnieszka Ewa Pozarska." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1216142548/34.
Full textFryer, Anthony Alan. "Studies on the biochemical development of human lung and brain." Thesis, Keele University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306225.
Full textNakamura, Tomonori. "Essential roles of ECAT15-2/Dppa2 in functional lung development." Kyoto University, 2011. http://hdl.handle.net/2433/151943.
Full textPozarska, Agnieszka Ewa [Verfasser]. "Tgfbr3 regulates alveolarisation in late lung development / Agnieszka Ewa Pozarska." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1216142548/34.
Full textMuranishi, Yusuke. "Development of a novel lung-stabilizing device for VATS procedures." Kyoto University, 2019. http://hdl.handle.net/2433/242353.
Full textLee, Matthew John. "Ultrastructural localisation of drug-metabolising enzymes within lung and their role in the development of cell-specific lung injury." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282748.
Full textMcColm, Janet R. "Inflammatory mediators in the lungs of preterm infants and their role in the development of chronic lung disease." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/21402.
Full textBovard, Joshua Maschio. "Does competitive swimming during puberty affect lung development in pubertal females?" Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62896.
Full textEducation, Faculty of
Kinesiology, School of
Graduate
Deimling, Julie F. "Epithelial-mesenchymal interactions and the Notch pathway in mammalian lung development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0002/MQ46042.pdf.
Full textGroenman, Frederick Anton. "Hypoxia inducible factor a breath of fresh air in lung development /." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10347.
Full textChari, Rajagopal. "Development and application of an integrative genomics approach to lung cancer." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/26001.
Full textCornejo, Perales Salomon. "Mechanisms of glucocorticoid responsiveness in the lung during development and inflammation." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116918.
Full textLes glucocorticoïdes (GC) sont des hormones vitales impliquées dans le développement des poumons et de la régulation de la réponse inflammatoire/immunitaire. Une grande variation interindividuelle de la réactivité des GC existe chez les patients utilisant des stéroïdes comme traitement pour les maladies inflammatoires. Les preuves suggèrent que la vitamine D (VitD), une autre molécule impliquée dans le développement des poumons, améliore la fonction des GC. Même si des progrès ont été réalisés dans l'étude de l'insensibilité aux stéroïdes, les mécanismes moléculaires ne sont pas complètement élucidés et les effets de la réponse compromise aux GC au cours du développement pulmonaire n'ont pas été explorés. Le premier objectif de cette thèse est d'étudier les mécanismes de réactivité des stéroïdes dans l'asthme en utilisant des modèles murins de la maladie. La souche Balb/c a démontré un phénotype d'insensibilité aux stéroïdes associé à des quantités accrues de p38 MAPK sous forme active et l'inactivation subséquente du récepteur des GC (GR) après provocation par un allergène. De plus, des lignées cellulaires lymphoblastiques provenant d'enfants asthmatiques ont été utilisées pour étudier les mécanismes de réactivité variable des GC et ont permis d'explorer le rôle modulateur de la VitD sur la fonction des GC. Chez les enfants asthmatiques, une faible réactivité aux stéroïdes a été associée à une biodisponibilité nucléaire limitée du GR à la suite de l'expression basale diminuée du GR et de la rapide régulation négative induite par l'hormone. Des évidences suggérant un effet bénéfique de la VitD sur la sensibilité aux stéroïdes sont présentées. Enfin, la réactivité des stéroïdes et la modulation de la fonction des GC par la VitD ont été étudiées dans les cellules épithéliales du poumon en développement des modèles de rats normaux et atopiques. L'épithélium des voies respiratoires du rat atopique semble être plus sensible aux stéroïdes, en rendant possiblement les poumons plus susceptibles aux effets néfastes des GC, et la réponse des GC est atténuée par la VitD. Cette thèse met en évidence la complexité de la fonction de stéroïdes et de sa régulation par des mécanismes multiples allant de l'expression altérée, l'activation réduite, la translocation nucléaire anormale et l'augmentation de la régulation négative homologue des GC.
Sokolova, Natalia Valerievna. "The role of vitamin A in embryonic lung development in mice." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320687.
Full textWang, Jau-Yi. "Development of multiple-breath-helium-washout system for lung function studies." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/14451/.
Full textChudasama, Dimple. "Discovery and development of liquid biomarkers for ovarian and lung cancer." Thesis, Brunel University, 2018. http://bura.brunel.ac.uk/handle/2438/16174.
Full textAlmurshedi, A. "Development of Afatinib lipid nanoparticles targeting non small cell lung cancer." Thesis, Liverpool John Moores University, 2018. http://researchonline.ljmu.ac.uk/9111/.
Full textXu, Zizhao. "Development of Lipid-based Nano Formulations of Miriplatin Against Lung Cancer." Scholarly Commons, 2020. https://scholarlycommons.pacific.edu/uop_etds/3699.
Full textMETZGER, DAVID EDWARD. "THE ROLE OF THE ETS TRANSCRIPTION FACTOR Elf5 IN LUNG DEVELOPMENT." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1197664589.
Full textMoncada, Benavides Camilo Andres. "EFFECT OF NICOTINE ON LUNG S-ADENOSYLMETHIONINE AND PNEUMOCYSTIS PNEUMONIA DEVELOPMENT." Diss., Temple University Libraries, 2012. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/206623.
Full textPh.D.
Infection with "Pneumocystis" causes a ≥ 99% depletion of plasma S-adenosylmethionine (AdoMet) levels in both "Pneumocystis" pneumonia (PcP) animal models and patients. AdoMet is a critical cellular metabolic intermediate, with a pivotal role as methyl donor in a myriad of biochemical processes and necessary for the synthesis of the essential polyamines spermidine and spermine. In the target tissue of "Pneumocystis", the lung, levels of AdoMet were previously shown to be depleted experimentally using nicotine. Here we show that chronic administration of nicotine in an animal model of PcP resulted in decreased lung AdoMet content. Since "Pneumocystis" is dependent on this metabolite, PcP burden was also relived. We hypothesized that the underlying mechanism behind nicotine-induced AdoMet depletion was an increased consumption of AdoMet through the polyamine pathway where the increased activity of N-1-spermidine/spermine acetyl transferase raises the catabolic / anabolic cycling of polyamines, a process that utilizes AdoMet. In a critical test of our hypothesis, we found that blockage of polyamine metabolism via inhibition of the polyamine biosynthetic enzyme ornithine decarboxylase (ODC) hinders the effect of nicotine on lung AdoMet levels. Further support is provided by metabolite analyses showing nicotine to cause a strong diversion of AdoMet toward polyamine synthesis and away from methylation reactions; these shifts are also reversed by inhibition of ODC. Because the nicotine effect on "Pneumocystis" is so striking, we considered the possibility of tissue specificity. Using laser capture microdissection (LCM), we collected samples of lung alveolar regions (site of infection) and respiratory epithelium for controls. We found nicotine to cause increased ODC activity in alveolar regions but not airway epithelium; we conclude that tissue specificity likely contributes to the effect of nicotine on "Pneumocystis" pneumonia. Our studies demonstrate the feasibility of pharmacological manipulation of the polyamine pathway in order to reduce AdoMet levels in the lung and prompted the assessment of compounds alternative to nicotine with the potential to achieve a comparable effect. In vitro evaluation of the polyamine analog DENSPM along with putrescine in type II alveolar cell lines, indicates that although such a combination has the potential to induce polyamine flux, an apparent competition for the same polyamine transport system impairs simultaneous uptake of both compounds at effective concentrations. In conclusion, we showed that chronic nicotine administration causes reduction of AdoMet levels in rat lung following 21 days of treatment, by a mechanism involving the induction of polyamine flux, which is responsible of increased AdoMet utilization for polyamine biosynthesis. According to LCM-based analysis, this effect seems to be confined to the alveolar regions of the lung.
Temple University--Theses
Ntokou, Aglaia [Verfasser]. "The role of pulmonary fibroblast subtypes in lung development / Aglaia Ntokou." Gießen : Universitätsbibliothek, 2018. http://d-nb.info/1152943898/34.
Full textKolck, Johannes [Verfasser]. "The role of miR-154 in early lung development / Johannes Kolck." Gießen : Universitätsbibliothek, 2020. http://d-nb.info/1216145245/34.
Full textAmelon, Ryan. "Development and characterization of a finite element model of lung motion." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3422.
Full textLatzin, Philipp. "Lung development in health and disease : early-life risk factors and their impact on lung function, inflammation and respiratory symptoms /." [S.l.] : [s.n.], 2009. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Full text