Dissertations / Theses on the topic 'Lung and breast'
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Cheng, Wing-ming Edward. "Emotional well-being in Chinese lung cancer patients." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B3197157X.
Gupta, Gaorav. "Breast cancer metastasis to the lungs : from genes to mechanisms /." Access full-text from WCMC :, 2007. http://proquest.umi.com/pqdweb?did=1456287491&sid=10&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Cheng, Wing-ming Edward, and 鄭永明. "Emotional well-being in Chinese lung cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B3197157X.
Cong, Chunling. "Statistical Analysis and Modeling of Breast Cancer and Lung Cancer." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3563.
Prochazka, Michaela. "The risk of second primary lung carcinoma in breast cancer patients /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-649-2/.
Hellmold, Heike. "Toxicological and endocrinological aspects of cytochrome P450 in breast and lung /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-2787-1.
Smith, Sarah Jane. "Cancer in Trent region : incidence, mortality and survival." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312199.
Arenas, Lahuerta Enrique Javier. "Identification of novel mechanisms in human breast cancer lung metastasis and chemoresistance." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/404730.
El cáncer de mama (BC, de sus siglas en inglés) es una de las mayores causas de muerte por cáncer en mujeres. El cáncer de mama es una enfermedad heterogénea, y en la heterogeneidad del tumor, las células iniciadoras tumorales (TICs, del inglés) han sido asociadas como importantes responsables en la iniciación y progresión tumoral. Basándonos en estas observaciones, nuestra hipótesis es si estas células contribuyen en la metástasis y quimioresistancia en el cáncer de mama. A través de análisis genéticos, transcriptómicos, moleculares y terapéuticos en xenoinjertos tumorales, líneas celulares y tumores humanos, en esta tesis hemos revelado en primer lugar que RARRES3, es un gen de supresión metastática en pulmón, que previene la adhesión al parénquima pulmonar y la iniciación de lesiones metastáticas, imponiendo las características de diferenciación, y cuya retención es causada por la actividad catalítica PLA1/2. Estos resultados indican que la actividad genética de RARRES3 bloquea específicamente la metástasis a pulmón y las propiedades de iniciación metastática. Además, hemos descrito una relación entre las los genes con características de autorenovación (EVI1 y SOX9) y resistencia a inhibidores de mTOR, que termina con una fenotipo más agresivo y metastático. Conjuntamente, los datos mostrados en esta tesis demuestras evidencias novedosas relacionadas con las propiedades de iniciación tumoral en distintos contextos: I) progresión y metástasis en el cáncer de mama; II) como la progresión tumoral está funcionalmente relacionada con la resistencia a inhibición de mTOR; y III) como la resistencia a terapia que está desencadenada por estas propiedades de iniciación tumoral pueden al final producir un fenotipo más agresivo y metastático
Iliopoulos, Dimitrios. "The role of the WWOX tumor suppressor in breast and lung cancer." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1155142398.
Allaire, Patrick. "Erk12 provides retinoic acid resistance to breast and lung cancer cell lines." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78236.
Iliopoulos, Dmitrio. "The role of the WWOX tumor suppressor in breast and lung cancer." The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1155142398.
Wolstenholme, Jane. "Counting the costs of cancer care : breast, cervical and lung cancer in Trent." Thesis, University of Nottingham, 2001. http://eprints.nottingham.ac.uk/12097/.
Smith, Peter Gerard. "Potentiation of multi-targeted antifolate activity by novel dipyridamole analogues." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311118.
Ramroth, Johanna Rankin. "Radiotherapy dose-fractionations and outcomes in cancer patients." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:8c5a99de-7d8c-4b19-9a91-e6cf4efa7bd2.
Loon, Adriana Johanna Maria van. "Socioeconomic status, lifestyle and the risk of cancer of lung, breast, colon and stomach." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1997. http://arno.unimaas.nl/show.cgi?fid=5808.
Patki, Mugdha. "Novel Actions of Steroid Receptors that Limit Treatment Response in Breast and Lung Cancers." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1382094235.
Stantic, Marina. "Targeting Breast Tumour-Initiating Cells with Vitamin E Analogues." Thesis, Griffith University, 2012. http://hdl.handle.net/10072/366928.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Griffith Health
Full Text
Khan, Zareen A. "The role of integrins in the activation of fibroblasts from skin, lung and breast tissue." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25902.
Mendes, Odete Rodrigues. "Role of MMP2, MMP3 and MMP9 in the development of breast cancer brain and lung metastasis in a syngeneic rat model." Texas A&M University, 2005. http://hdl.handle.net/1969.1/2645.
Padua, David M. "Identifying a role for TGF-beta signaling in breast cancer metastasis to the lungs /." Access full-text from WCMC, 2008. http://proquest.umi.com/pqdweb?did=1619237911&sid=4&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Yousuf, Ghadah Khaled. "The Effect of Violacein Extracted from Chromobacterium violaceum on Growth of Breast, Colon, Lung, and, Prostate Cancer Cell Lines." Thesis, Tennessee State University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10243226.
Chromobacterium violaceum (CV) produces a violet color pigment known as Violacein. It has been reported that violacein has anticancer activity. This compound is produced by CV a gram-negative facultatively anaerobic bacterium found in soil and water environmental samples. The purpose of this study was to determine the effect of purified violacein on select cancer cell lines. Violacein used in this study was purified from CV strain (14N23), a strain isolated from environmental samples collected in the Tennessee Copper Basin. The previous reports used a crude extract preparation of violacein; thus, it was of interest to determine the effect of the pure compound on cancer cell growth was similar to that of the crude extracts. The compound purified following the method of Mehta, et al. was exposed to cancer cells and cell death assessed using the Alamar Blue procedure. It was found that violacein had no effect on A549, BT549, and PC3 cancer cell growth; however, there was a significant effect on Colo-320 cancer cells. It was concluded that further studies are required to assess the effect of violacein on enzymes and proteins involved in the cancer cell apoptotic pathways. Such studies will explain why cancer cell death was observed in certain cancer cells and not others.
Valerio, Ciccone. "Endothelium as therapeutic target in breast and lung cancer progression: the role of nitric oxide and stemness marker ALDH1A1." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1069378.
KIM, Young-Hak. "Expression of breast cancer resistance protein is associated with a poor clinical outcome in patients with small-cell lung cancer." Kyoto University, 2011. http://hdl.handle.net/2433/135385.
Guajardo, Olga A. "A critical assessment of geographic clusters of breast and lung cancer incidences among residents living near the Tittabawassee River, Michigan /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1594501451&sid=11&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Nordman, Ina IC Clinical School St Vincent's Hospital Faculty of Medicine UNSW. "Surrogate endpoints of survival in metastatic carcinoma." Publisher:University of New South Wales. Clinical School - St Vincent's Hospital, 2008. http://handle.unsw.edu.au/1959.4/42791.
Morris, Eva. "The impact of the Calman-Hine report on the processes and outcomes of care for Yorkshire's breast, colorectal and lung cancer patients." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414496.
Nilsson, Kenneth. "Radiation induced pneumonitis : clinical and experimental studies with special emphasis on the effect of smoking." Doctoral thesis, Umeå universitet, Onkologi, 1992. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100545.
Diss. (sammanfattning) Umeå : Umeå universitet, 1992, härtill 5 uppsatser.
digitalisering@umu
FERRUCCI, VERONICA. "PRUNE-1 DRIVES THE RECRUITMENT AND THE POLARIZATION OF TUMOUR-ASSOCIATED MACROPHAGES (TAMS) PREPARING THE SOIL FOR LUNG METASTASES IN TRIPLE NEGATIVE BREAST CANCER." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/563230.
Ascha, Mustafa Steven. "Incidence and Treatment of Brain Metastases Arising from Lung, Breast, or Skin Cancers: Real-World Evidence from Primary Cancer Registries and Medicare Claims." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1554481284740082.
DE, LUCA FABRIZIO. "In vivo evaluation of the neuroprotective effects of a medicinal mushroom blend on breast metastases: cellular and molecular studies in CNS and lung." Doctoral thesis, Università degli studi di Pavia, 2022. http://hdl.handle.net/11571/1452905.
Hasim, Mohamed Shaad. "The Role of Activating Transcription Factor 3 as a Regulator of DNA-Damaging Chemotherapy Cytotoxicity." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39897.
Leonardi, Antonio. "Design, synthesis of substituted purines, phenylpyrrolidine derivatives, cyclic and acyclic bis (p-nitrobenzenesulfonamides), and in vitro anti-cancer activity against lung, breast and prostate cell lines." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1175.
Sanchez, Crespo Alejandro. "Novel computational methods for image analysis and quantification using position sensitive radiation detectors." Doctoral thesis, Stockholm University, Medical Radiation Physics (together with KI), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-754.
The major advantage of position sensitive radiation detector systems lies in their ability to non invasively map the regional distribution of the emitted radiation in real-time. Three of such detector systems were studied in this thesis, gamma-cameras, positron cameras and CMOS image sensors. A number of physical factors associated to these detectors degrade the qualitative and quantitative properties of the obtained images. These blurring factors could be divided into two groups. The first group consists of the general degrading factors inherent to the physical interaction processes of radiation with matter, such as scatter and attenuation processes which are common to all three detectors The second group consists of specific factors inherent to the particular radiation detection properties of the used detector which have to be separately studied for each detector system. Therefore, the aim of this thesis was devoted to the development of computational methods to enable quantitative molecular imaging in PET, SPET and in vivo patient dosimetry with CMOS image sensors.
The first task was to develop a novel quantitative dual isotope method for simultaneous assessments of regional lung ventilation and perfusion using a SPET technique. This method included correction routines for photon scattering, non uniform attenuation at two different photon energies (140 and 392 keV) and organ outline. This quantitative method was validated both with phantom experiments and physiological studies on healthy subjects.
The second task was to develop and clinically apply a quantitative method for tumour to background activity uptake measurements using planar mammo-scintigraphy, with partial volume compensation.
The third stage was to produce several computational models to assess the spatial resolution limitations in PET from the positron range, the annihilation photon non-collineairy and the photon depth of interaction.
Finally, a quantitative image processing method for a CMOS image sensor for applications in ion beam therapy dosimetry was developed.
From the obtained phantom and physiological results it was concluded that the methodologies developed for the simultaneous measurement of the lung ventilation and perfusion and for the quantification of the tumour malignancy grade in breast carcinoma were both accurate. Further, the obtained models for the influence that the positron range in various human tissues, and the photon emission non-collinearity and depth of interaction have on PET image spatial resolution, could be used both to optimise future PET camera designs and spatial resolution recovery algorithms. Finally, it was shown that the proton fluence rate in a proton therapy beam could be monitored and visualised by using a simple and inexpensive CMOS image sensor.
Kunath, Tobias. "Analyse des Langzeitüberlebens von Patientinnen mit Mammakarzinom nach Lungenmetastasenresektionen mit 1318 nm Laser zweier Generationen und des Rezeptorverhaltens von Primärtumor und Lungenmetastasen." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-232601.
Background: Breast carcinoma is the most common type of cancer in women worldwide and is still regarded as a systemic disease. After primary treatment five-year survival rates around 80% are reported. However, the mean survival time of stadium-IV classified patients is 20-30 months. 5-15% of patients appear with isolated metastases of the lungs which can be considered as an oligometastatic and, therefore, stable intermediate stage in disease process. Several studies point out that especially these women are more likely to benefit from resection of lung metastases than from systemic therapy alone. Furthermore, there is the possibility of a discordant expression of typical receptors (Estrogen-, Progesterone- and HER2-receptor) between primary breast cancer and its paired metastases. As a result a change in treatment regimen might be necessary. Objective: The aim of the present study was to evaluate long-time survival of patients with lung metastases from breast cancer who have been operated exclusively with a new parenchyma-saving and lobe-sparing 1318-nm-lasertechnique. Additionally, the identification of independent prognostic factors was of interest. Furthermore, existence and magnitude of receptor discordance, specifically for distant pulmonary metastases, should be proved. Patients and methods: Within this retrospective study between 1996 and 2012 102 patients (mean age 58; range 33-78 years) underwent curative laser metastasectomy and systematic lymphadenectomy. Inclusion criteria were complete resection of primary breast cancer and absence of extrapulmonary/-thoracal metastases or its previous total treatment. Although there were no limitations regarding the number of metastases, technical resectability and functional operability had to be assumed after the preoperative diagnostics. Kaplan-Meier-analysis was performed to assess overall survival in all patients and selected subgroups. Uni- and multivariate analyses of prognostic factors were performed using the Cox-proportional-hazard model. Comparison of the receptor status of primary breast cancer and paired lung metastases was assessed by the McNemare method. Significant results were assumed if p-values were <0.05. Results: In total 936 intrapulmonary nodules had been resected, including 716 histopathologically confirmed breast cancer metastases. The amount reached from a single metastasis up to 61 two-staged removed pulmonary nodules (mean 7 per patient). The lobectomy rate was 0.98%. In 7.8% of all cases segment-resections, also performed by laser, were possible. Complete resection was achieved in 73.5% (n=75). The median overall survival time was 43 months and the five-year survival rate was 46.1%. As independent prognostic factors resection status (p=0.02), involvement of intrathoracal lymph nodes (p=0.001) and expression of estrogen receptor (p=0.018) were identified. The mortality rate in case of lymph node involvement and negative estrogen receptor status was increased by 3.2- and 2-fold, respectively. The number of resected metastases, type of lung affection (uni-/bilateral), disease free interval after primary breast surgery ( 36 months), and expression of progesterone receptor had no significant influence on survival. Data concerning the primary and metastatic hormone receptor- and HER2-status were available in 88.2% (n=90) and 62.7% (n=64) of all cases, respectively. Discordant results appeared in 26.7%, 41.1%, and 28.1% regarding the estrogen-, progesterone- and HER2-receptor. Significance of these findings had only been proved for estrogen receptor (p=0.002). A subanalysis of the present study revealed that 65.5% of 157 breast cancer patients who presented with newly occurred radiologically detectable pulmonary nodules had histopathologically confirmed paired metastases. The remaining results showed malignancies other than known breast cancer, and in approximately 20% of all cases there were benign lesions. Conclusions: The results of the present study emphasize the favorable effect of the lung metastasectomy on survival of selected breast cancer patients with isolated pulmonary oligometastatic disease. Via the use of the parenchyma-saving 1318nm-lasertechnique even in case of distinct and bilateral pulmonary metastatic involvement, increased rates of complete resection without substantial loss of lung function can be achieved. Therefore, an adequate quality of life is provided. In comparison with conventional surgery practices, this procedure creates similar survival rates despite higher numbers of resected lung metastases. That is why the number of preoperatively diagnosed metastases should have little influence on decision upon surgery. Thus, an extension of inclusion criteria seems reasonable. Again, complete resection appeared as one of the most important prognostic parameters and should, therefore, be the main objective of the surgeon. The poorer outcome for women with incomplete resections and the results of studies on systemic therapy implicate once more that breast cancer patients are more likely to benefit from the resection of their pulmonary metastases than from medical treatment alone. Furthermore, for the first time according to our knowledge, despite radical excision intrathoracal lymph node involvement has been proved as a significant negative predictive determinant in a collective of patients with isolated pulmonary metastases of breast cancer. Nevertheless, an intraoperative systematic lymph node sampling should be considered, at least until further studies are presented. In reference to the surgical approach of lung carcinoma, as circumstances require, a complete lymph node dissection should be performed to provide potential curative treatment to those affected. Moreover, according to the present findings, in case of the appearance of lung metastases the constancy of metastatic steroid hormone- and HER2 receptor expression, especially of the estrogen receptor, cannot always be assumed. Changes in comparison to the primary carcinoma appear in a relevant number of cases. Thus, the current metastatic receptor status should be evaluated obligatorily after pulmonary metastasectomy. Regarding the origin of pulmonary nodules of patients with history of breast cancer, their surgical resection with subsequent histopathological analysis can reliably differentiate between metastases, lung carcinoma or benign tumors. Altogether this facilitates specific and accurate treatment decisions. However, to identify patients with a limited and stable oligometastatic state of disease and to introduce optimal treatment, including surgical resection, an early, continuous, and also instrument-based follow-up is necessary. This matter is still only slightly taken into account, while the authors of the current guidelines refer to out of date studies, which have to be seen critically. As limitations of the present investigation, the retrospective study design, inconsistent evaluation of the primary receptor status, and also heterogeneity of postoperative medical therapy must be mentioned. In the future larger, multicentric, prospective, randomized trials are necessary to acquire further data, to conceivably continue to establish the pulmonary laser metastasectomy in multimodal therapy settings and also to determine the value of an extended follow-up
Šimonková, Karolína. "Porovnání účinnosti vybraných metod léčení rakoviny prostaty a prsu pomocí analýzy přežití." Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-359539.
Uthoff, Johanna Mariah. "Cancer risk assessment using quantitative imaging features from solid tumors and surrounding structures." Diss., University of Iowa, 2019. https://ir.uiowa.edu/etd/6869.
Rossdeutscher, Lionel Philip David. "The role of tumoral 1,25 dihydroxyvitamin D3 in inhibition of tumor growth and progression in the PyVMT MMTV#634 transgenic breast cancer model /." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112354.
Dixon, Christina L. "Examining Fear of Recurrence in Cancer Survivors." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/6417.
Rosell, Johan. "Long-term effects of adjuvant tamoxifen treatment on cardiovascular disease and cancer." Doctoral thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-112085.
May, Peter [Verfasser], and Sebastian [Akademischer Betreuer] Kobold. "Characterization of CD4-memory T helper cell populations as a source of interleukin-22 production in murine and human breast and lung cancer models / Peter May ; Betreuer: Sebastian Kobold." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1199265438/34.
Mount, David, Charles Putnam, Sara Centouri, Ann Manziello, Ritu Pandey, Linda Garland, and Jesse Martinez. "Using logistic regression to improve the prognostic value of microarray gene expression data sets: application to early-stage squamous cell carcinoma of the lung and triple negative breast carcinoma." BioMed Central, 2014. http://hdl.handle.net/10150/610040.
most of them were B-cell related. When the same data set of stage I and II cases was analyzed using a conventional Kaplan Meier (KM) approach, we identified fewer immune-related genes among the most statistically significant hits
when stage III cases were included, most of the prognostic genes were missed. Interestingly, logistic regression analysis of the breast cancer data set identified many immune-related genes predictive of clinical outcome.CONCLUSIONS:Stratification of cases based on clinical data, careful selection of two groups for comparison, and the application of logistic regression analysis substantially improved predictive accuracy in comparison to conventional KM approaches. B cell-related genes dominated the list of prognostic genes in early stage SQCC of the lung and triple negative breast cancer.
Burgess, Joshua T. "The role of SAM and SH3 domain-containing protein 1 (SASH1) in DNA damage repair and tumourigenesis." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/98661/1/Joshua_Burgess_Thesis.pdf.
Woods, Tonya M. "Extracting meaningful statistics for the characterization and classification of biological, medical, and financial data." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/53857.
Niksic, Maja. "Public cancer awareness and cancer survival in England : recognition of cancer symptoms and perception of barriers to seeking medical help in relation to breast, lung and bowel cancer survival in England." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/public-cancer-awareness-and-cancer-survival-in-england(d8715922-6635-4840-8c4f-66c26adbf0c2).html.
Velazquez, Quesada Ines. "Identification et caractérisation de nouveaux mécanismes moléculaires et cellulaires dépendant de la Ténascine-C et impliqués dans l'agressivité du cancer du sein." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ082/document.
The microenvironment, which comprises the extracellular matrix (ECM), plays instrumental roles during tumor formation and progression. Tenascin-C (TNC) is a major ECM component highly expressed in breast cancer, correlating with poor prognosis, tamoxifen resistance and lung metastasis formation. TNC exerts pleiotropic effects by promoting tumor cell survival, proliferation and invasion as well as angiogenesis , inflammation and metastasis. The main goal of my thesis was to try to comprehensively understand the several contributions of TNC during breast cancer establishment and progression to metastatic disease. My analyses revealed that the absence of TNC does not affect breast tumorigenesis in the MMTV-PyMT breast cancer mouse model, confirming a previous study. More interestingly, using the MMTV-NeuNT model, we show that TNC promotes primary tumor initiation and lung metastatic colonization. In the lung, TNC increases of cancer cell survival in intravascular metastases and promotes their progression. Additionally, we established breast cancer cell lines from MMTV-PyMT and MMTV-NeuNT mouse models that grow in vitro and are tumorigenic when re-Implanted in syngeneic, fully immuno-Competent mice. In this work we had shown that TNC participates in tumor initiation and in lung metastasis colonization in an ErbB2-Driven transgenic breast cancer mouse model. The established cell lines are alternative tools useful for in vivo and in vitro studies in breast cancer research
Toullec, Alexis. "Dispositif d’aiguille fibrée pour la spectroscopie de fluorescence endogène de lésions mammaires et pulmonaires ex vivo et in vivo ; vers le développement d'une méthode d’ histopathologie in situ." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS154/document.
The third Cancer Plan, launched in 2013, identifies early diagnosis as one of the major challenges for improving patient care. Despite the growth in medical imaging modalities and performance, challenges remain in diagnosis aid and optimizing the use of biopsy.Photonic imaging and especially spectrally resolved fluorescence has already been tested for the ex vivo characterization of breast and lung tumors, without contrast agent or sample processing. Our goal is to characterize the capabilities of an innovative medical device, developed in the laboratory, using a low-caliber fibered needle for the spectral analysis of the endogenous fluorescence of these lesions in situ. Our early work in preclinical and clinical studies showed significant differences in spectral signatures between benign and malignant tumors ex vivo and in vivo. Our results also highlighted the limits the device, in terms of specificity, for certain types of lesions.Another study was conducted on mammary tumors in order to identify the major tissue entities at the origin of the spectral signatures obtained with our fibered device. Spectral imaging in confocal and second harmonic microscopy (SHG), in multiphoton, has been implemented in order to establish a mapping of endogenous biomarkers of mammary tissues. We compare its results with the data obtained with the fibered needle device in order to position it not only as an aid to diagnosis but also as a promising method for in situ histopathology
Mijnes, Jolein [Verfasser], Edgar Akademischer Betreuer] Dahl, Ralph [Akademischer Betreuer] [Panstruga, and Gabriele [Akademischer Betreuer] Pradel. "Identification, validation and characterization of novel DNA methylation biomarkers for liquid biopsy based early breast cancer detection and therapy monitoring in non-small cell lung cancer / Jolein Mijnes ; Edgar Dahl, Ralph Panstruga, Gabriele Pradel." Aachen : Universitätsbibliothek der RWTH Aachen, 2020. http://d-nb.info/1225401690/34.
Mijnes, Jolein Verfasser], Edgar [Akademischer Betreuer] Dahl, Ralph [Akademischer Betreuer] [Panstruga, and Gabriele [Akademischer Betreuer] Pradel. "Identification, validation and characterization of novel DNA methylation biomarkers for liquid biopsy based early breast cancer detection and therapy monitoring in non-small cell lung cancer / Jolein Mijnes ; Edgar Dahl, Ralph Panstruga, Gabriele Pradel." Aachen : Universitätsbibliothek der RWTH Aachen, 2020. http://d-nb.info/1225401690/34.
Hall, Charles. "Ex vivo reprogramming of tumor-reactive immune cells from FVBN202 mice bearing lung metastatic mammary carcinoma: an immunotherapeutic opportunity revealed against recurrence." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3176.
Johansson, David. "Bacterial toxins for cancer treatment." Doctoral thesis, Umeå universitet, Medicinsk biovetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1637.