Journal articles: 'Lugano (Switzerland)'

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Moccetti, Tiziano. "Cardiocentro Ticino in Lugano, Switzerland." European Heart Journal 38, no. 1 (January 1, 2017): 11–12. http://dx.doi.org/10.1093/eurheartj/ehw588.

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Hauswirth, Matthias, Jan Vahrenhold, Diana Franklin, and Kathi Fisler. "ICER 2022 call for participation." ACM SIGCSE Bulletin 54, no. 2 (April 2022): 6. http://dx.doi.org/10.1145/3538522.3538527.

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The 18th annual ACM Conference on International Computing Education Research (ICER) will be hosted by Università della Svizzera italiana (USI) in beautiful Lugano, Switzerland. This hybrid conference will take place August 7-11, 2022. You can participate physically by traveling to Lugano or virtually through our conference platform.

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Drissner, J., E. Klemt, T. Klenk, R. Miller, G. Zibold, M. Burger, and A. Jakob. "Investigations on the caesium-137 household of Lake Lugano, Switzerland." Czechoslovak Journal of Physics 49, S1 (January 1999): 133–39. http://dx.doi.org/10.1007/s10582-999-0018-3.

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Kovacs, Zoltan. "The First European Aquaphotomics Meeting 28–29 April 2017, Lugano, Switzerland." NIR news 28, no. 6 (September 2017): 7–8. http://dx.doi.org/10.1177/0960336017727448.

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Hills, M. J. "Symposium on the Mediterranean Diet Lugano, Switzerland, 30 September-1 October 1994." European Journal of Cancer Prevention 4, no. 2 (April 1995): 205. http://dx.doi.org/10.1097/00008469-199504000-00014.

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Stevens, David A. "Advances against Aspergillosis and Mucormycosis." Journal of Fungi 6, no. 4 (December 11, 2020): 358. http://dx.doi.org/10.3390/jof6040358.

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The 9th meeting of Advances Against Aspergillosis in beautiful Lugano, Switzerland clearly had the most drama of any of the previous meetings, exceeding even the 1st one, in San Francisco, when we, the Co-Organizers, weren’t sure that although we had a great educational idea, and had put together a great list of speakers and topics, we might have few attendees, and go bankrupt! (The story of the birth efforts in initiating these meetings is described, for the historical record [...]

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Aeschbach-Hertig, W., C. P. Holzner, M. Hofer, M. Simona, A. Barbieri, and R. Kipfer. "A time series of environmental tracer data from deep meromictic Lake Lugano, Switzerland." Limnology and Oceanography 52, no. 1 (January 2007): 257–73. http://dx.doi.org/10.4319/lo.2007.52.1.0257.

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Holzner, C. P., W. Aeschbach-Hertig, M. Simona, M. Veronesi, D. M. Imboden, and R. Kipfer. "Exceptional mixing events in meromictic Lake Lugano (Switzerland/Italy), studied using environmental tracers." Limnology and Oceanography 54, no. 4 (May 8, 2009): 1113–24. http://dx.doi.org/10.4319/lo.2009.54.4.1113.

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Gibson, Angelia D., Amy D'Orazio, Fredrick B. Hagemeister, Michael Grossbard, and Vinay K. Jain. "Highlights From: VIII International Conference on Malignant Lymphoma June 12–15, 2002 Lugano, Switzerland." Clinical Lymphoma 3, no. 2 (September 2002): 75–81. http://dx.doi.org/10.1016/s1526-9655(11)70255-x.

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Lee, David, Angelia Gibson, Vinay K. Jain, and James O. Armitage. "Highlights From: VIII International Conference on Malignant Lymphoma June 12–15, 2002 Lugano, Switzerland." Clinical Lymphoma 3, no. 3 (December 2002): 139–44. http://dx.doi.org/10.1016/s1526-9655(11)70270-6.

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Simpson, Sally. "The European Society for Medical Oncology Conference Lugano 2007, Switzerland; July 5–8, 2007." Lancet Oncology 8, no. 9 (September 2007): 769. http://dx.doi.org/10.1016/s1470-2045(07)70269-3.

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Eska, Joseph F., and Charlene M. Eska. "Epigraphic and linguistic observations on the inscription at the so-called Mur d’Hannibal (Liddes, Valais)." Zeitschrift für celtische Philologie 69, no. 1 (November 22, 2022): 159–82. http://dx.doi.org/10.1515/zcph-2022-0002.

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Abstract This paper argues that the inscription engraved in the Alphabet of Lugano in sinistrograde ductus at the so-called Mur d’Hannibal (Liddes, Valais, Switzerland) should be read as Poenino | ieur{e}u ‘he dedicated to P.’ The first form is a thematic dative singular. The desinence may well be Latin, but a case is made that it could be a Celtic desinence that displays a regional phonological development. The fourth character of the second form is a reversed Roman open Я, well attested in Cisalpine and Transalpine Celtic epigraphy. This form also displays a token of dittography, a phenomenon attested elsewhere in the Continental Celtic epigraphic corpus.

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Blum, A. L., T. C. Chalmers, E. Deutsch, J. Koch-Weser, A. Rosén, N. Tygstrup, and R. Zentgraf. "The Lugano Statements on Controlled Clinical Trials." Journal of International Medical Research 15, no. 1 (January 1987): 2–22. http://dx.doi.org/10.1177/030006058701500102.

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During a consensus conference in Lugano, Switzerland, 175 statements on controlled clinical trials were drafted by 47 representatives from academia, governmental registration agencies and industry in nine countries. Their opinion on these statements was similar to that of 47 ‘matched pairs’ who did not attend the conference. Thus, the opinion of participants and non-participants appears to reflect the general opinion of those currently involved in designing, conducting and analysing controlled clinical trials. The Lugano statements give answers to the following questions: Is the controlled clinical trial in a crisis? What is the motivation to perform controlled clinical trials? Is it possible for a physician participating in a controlled clinical trial to act in the patient's best interest? Is it possible to obtain truly informed consent in a controlled clinical trial? When is it ethical to withhold active treatment in a controlled clinical trial? What are the controversial issues in the design of a good controlled clinical trial? Is there a double standard with respect to efficacy and adverse drug reactions in controlled clinical trials? What are the alternatives to controlled clinical trials and when should they be performed? How can sponsor bias be minimized? How should an ethics committee decide whether a controlled clinical trial is Should? ethical registration agencies become directly involved in the planning and conduct of controlled clinical trials? Do the declarations of Tokyo and Helsinki facilitate the conduct of ethically valid controlled clinical trials? Is it possible to create an international standard for the conduct and regulation of controlled clinical trials? Why do messages from controlled clinical trials filter into medicine so slowly? Is it possible to bridge the gap between controlled clinical trials and clinical reality? What are the costs of doing and not doing controlled clinical trials? When should drug companies decide to start a trial programme with a specific compound? Is there public hostility against controlled clinical trials? If so, how can it be reduced? The respondents almost unanimously felt that controlled clinical trials are a must; the public must be told that progress in medicine depends on controlled clinical trials, that patients often benefit from participating in them and that the alternative, practising in the face of constant uncertainty, is worse than the possible disadvantages related to the conduct of the trial.

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Veronesi, Mauro L., Alberto Barbieri, and Kurt W. Hanselmann. "Phosphorus, carbon and nitrogen enrichment during sedimentation in a seasonally anoxic lake (Lake Lugano, Switzerland)." Journal of Limnology 61, no. 2 (August 1, 2002): 215. http://dx.doi.org/10.4081/jlimnol.2002.215.

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Thomas, B. A. "Behaviour of Some Trace Elements at the Oxic-Anoxic Interface in Lake Lugano (Switzerland, Italy)." Mineralogical Magazine 62A, no. 3 (1998): 1511–12. http://dx.doi.org/10.1180/minmag.1998.62a.3.127.

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Liu, Rongming, Annette Hofmann, Fazil O. Gülaçar, Pierre-Yves Favarger, and Janusz Dominik. "Methane concentration profiles in a lake with a permanently anoxic hypolimnion (Lake Lugano, Switzerland-Italy)." Chemical Geology 133, no. 1-4 (November 1996): 201–9. http://dx.doi.org/10.1016/s0009-2541(96)00090-3.

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Lepori, Fabio, James J. Roberts, and Travis S. Schmidt. "A paradox of warming in a deep peri-Alpine lake (Lake Lugano, Switzerland and Italy)." Hydrobiologia 824, no. 1 (May 24, 2018): 215–28. http://dx.doi.org/10.1007/s10750-018-3649-1.

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Blees, Jan, Helge Niemann, Markus Erne, Jakob Zopfi, Carsten J. Schubert, and Moritz F. Lehmann. "Spatial variations in surface water methane super-saturation and emission in Lake Lugano, southern Switzerland." Aquatic Sciences 77, no. 4 (July 22, 2015): 535–45. http://dx.doi.org/10.1007/s00027-015-0401-z.

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Curosu, Iurie, Viktor Mechtcherine, Daniele Forni, and Ezio Cadoni. "Dynamic Tensile Behaviour of Strain-Hardening Cement-Based Composites (SHCC)." EPJ Web of Conferences 183 (2018): 02015. http://dx.doi.org/10.1051/epjconf/201818302015.

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The paper presents a part of an experimental campaign consisting of quasi-static and impact tensile experiments on three different types of strain-hardening cement-based composites (SHCC) as well as on their constitutive cementitious matrices [1]. The investigation on different SHCC types was intended for analysing the effect of matrix composition and fibre type on the strain rate sensitivity of the composites and for enabling the formulation of material design recommendations for impact resistant SHCC. The dynamic tests were carried out by means of a Modified Hopkinson Bar (MHB) installed in the DynaMat Laboratory in Lugano, Switzerland, which enabled the characterization of the dynamic material behaviour under direct tensile loading in terms of force-displacement relationships.

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Monnerat, M. "Scavenging of Phosphorous by the ‘Ferrous Wheel’ in the Northern Basin of Lake Lugano (Switzerland/Italy)." Mineralogical Magazine 62A, no. 2 (1998): 1013–14. http://dx.doi.org/10.1180/minmag.1998.62a.2.197.

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Bechtel, Achim, and Carsten J. Schubert. "A biogeochemical study of sediments from the eutrophic Lake Lugano and the oligotrophic Lake Brienz, Switzerland." Organic Geochemistry 40, no. 10 (October 2009): 1100–1114. http://dx.doi.org/10.1016/j.orggeochem.2009.06.009.

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Rossi, Federica, and Rico Maggi. "Business travel decisions and high-speed trains: an ordered logit approach." REGION 6, no. 3 (December 20, 2019): 1–16. http://dx.doi.org/10.18335/region.v6i3.249.

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The paper studies the potential impact on business travel of the new high-speed railway line project, called AlpTransit, which will link Lugano, the small economic hub of the southern part of Switzerland, with Zurich, one of the major Swiss economic centres, situated north of the Alps. Thanks to this infrastructure, travel time between the two cities will decrease considerably from about three hours to less than two hours by the end of 2020. The question that we pose in this paper is what impact high-speed trains could have, in the short to medium term, on business travel between the two hubs (ex-ante evaluation). Indeed, given the travel time, firms could increase their business-to-business one-day trips, boosting face-to-face interactions within and among enterprises. Our curiosity more specifically regards the potential impact of the change in travel time on the propensity to travel of employees with different functions in various types of firms. An on-line survey was conducted among firms located in Ticino, the Swiss Canton that includes Lugano. The data are analysed using four ordered logit models, one for each employee category (CEO, administrative staff, sales personnel, specialists), since hierarchical position and professional status influence business travel characteristics. Results show that internal firm characteristics, such as sector, frequency and destination of current business travels significantly influence the propensity to travel to Zurich more often thanks to AlpTransit.

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Brignone, Stefano, Vanessa De Santis, Tiziano Putelli, Christophe Molina, Armando Piccinini, Richard A. Carmichael, and Pietro Volta. "What’s the effectiveness of stocking actions in small creeks? The role of water discharge behind hatchery trout downstream movement." PeerJ 10 (September 26, 2022): e14069. http://dx.doi.org/10.7717/peerj.14069.

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Fish stocking to enhance freshwater fisheries or to improve the conservation status of endangered fish species is a common practice in many countries. Little is known, however, of the effectiveness of these practices in spite of the high efforts and investments required. The movement of subadult/adult hatchery-released brown trout Salmo trutta L. was studied by passive telemetry in a small tributary of Lake Lugano (i.e., Laveggio Creek, Canton Ticino, Switzerland). Hatchery fish, together with some resident wild individuals sampled during electrofishing surveys, were tagged with Passive Integrated Transponders (PIT) tags. Hatchery fish were released upstream and downstream a submersible monitoring antenna, which was anchored to the streambed in a pass-over orientation. The number of hatchery fish detected daily by the antenna (divided between fish released upstream and downstream the antenna) was analyzed in relation to the daily water discharge, to search for similar patterns in their fluctuation over time. Only the movement of fish released upstream the antenna displayed a significant relationship with water discharge, with the highest number of fish detected during periods of high-water flow, occurring after heavy rains. High-water discharge events had a significant role in hatchery trout downstream movement in our study site, likely acting as a driver for the downstream migration to Lake Lugano. Such events contributed to the poor effectiveness of stocking actions in this small tributary, providing further evidence against stocking strategies based on subadult/adult fish.

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Cannata, M., D. Strigaro, F. Lepori, C. Capelli, M. Rogora, and D. Manca. "FOSS4G BASED HIGH FREQUENCY AND INTEROPERABLE LAKE WATER-QUALITY MONITORING SYSTEM." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVI-4/W2-2021 (August 19, 2021): 25–29. http://dx.doi.org/10.5194/isprs-archives-xlvi-4-w2-2021-25-2021.

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Abstract. Climate, together with human activities, is changing the natural dynamics in lake ecosystems and adding new challenges to the management of water resources. Recent studies on Lake Lugano, in Switzerland, showed for instance that the increased water temperature influence other processes such as lake stratification and mixing dynamics, algal blooms, colonisation by alien species, affecting the lake ecosystem as a whole. In such situation, real-time systems with high frequency measurements, together with the traditional discrete monitoring, can help in understanding dynamics and processes occurring on short time scales. To this aim, an open monitoring system largely composed by open source components is being developed for the high frequency monitoring of Lake Lugano. The system relies on the open source software istSOS either on the server and node sides applying the edge computing paradigm which is more and more adopted in the Internet of Things field. The implementation collects temperature and dissolved oxygen data from sensors positioned at six different depths of the lake and transmits them using the LoRa radio frequency to a data warehouse. At server side, the software architecture adopts the evolving technology based on containers where services can be grouped in a compose and easily deployed on a server. This paper aims to describe the adopted open source technology and demonstrate that it can be successfully used also in environmental monitoring where the accessibility is limited and the weather conditions can be unpredictable.

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Putyrskaya, V., E. Klemt, S. Röllin, J. A. Corcho-Alvarado, and H. Sahli. "Dating of recent sediments from Lago Maggiore and Lago di Lugano (Switzerland/Italy) using 137Cs and 210Pb." Journal of Environmental Radioactivity 212 (February 2020): 106135. http://dx.doi.org/10.1016/j.jenvrad.2019.106135.

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Ferreri, Andrés J. M., Lauren E. Abrey, Jean-Yves Blay, Bettina Borisch, Jacob Hochman, Edward A. Neuwelt, Joachim Yahalom, et al. "Summary Statement on Primary Central Nervous System Lymphomas From the Eighth International Conference on Malignant Lymphoma, Lugano, Switzerland, June 12 to 15, 2002." Journal of Clinical Oncology 21, no. 12 (June 15, 2003): 2407–14. http://dx.doi.org/10.1200/jco.2003.01.135.

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Under the sponsorship of the International Extranodal Lymphoma Study Group, a Multidisciplinary Workshop on primary CNS lymphoma (PCNSL) with over 50 participants from Europe, North America, Israel, and Australia was held as part of the Eighth International Conference on Malignant Lymphoma in Lugano, Switzerland (June 12 to 15, 2002). The main purposes of the Workshop were to exchange the latest scientific information, to analyze methodologic issues in the design of clinical trials, to reach a consensus on treatment recommendations and prognostic factors, to discuss clinical and molecular targets for future studies, and to establish an international collaborative group to conduct laboratory and clinical investigations in PCNSL. This article summarizes the contents of the Workshop, analyzes the current knowledge on the most relevant biologic and clinical issues in PCNSL, and focuses on fundamental challenges to be addressed in future studies.

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Vavassori, Alberto, Daniele Oxoli, and Maria Antonia Brovelli. "Population Space–Time Patterns Analysis and Anthropic Pressure Assessment of the Insubric Lakes Using User-Generated Geodata." ISPRS International Journal of Geo-Information 11, no. 3 (March 18, 2022): 206. http://dx.doi.org/10.3390/ijgi11030206.

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Human activities are one of the main causes of lake-water pollution and eutrophication. The study of human pressure around lakes is of importance to understand its effects on the lakes natural resources. Social media data is a valuable space–time-resolved information source to detect human dynamics. In this study, user-generated geodata, namely users’ location records provided by the Facebook Data for Good program, are used to assess population patterns and infer the magnitude of anthropic pressure in the areas surrounding the Insubric lakes (Maggiore, Como and Lugano) between Northern Italy and Southern Switzerland. Patterns were investigated across different lakes’ neighbouring areas as well as seasons, days of the week, and day hours in the study period May 2020–August 2021. Two indicators were conceived, computed and mapped to assess the space–time distribution of users around lakes and infer the anthropic pressure. The highest pressure was found around lakes Maggiore and Como coastal areas during weekends in summer (up to +14% average users presence than weekdays in winter), suggesting tourism is the primary accountable reason for the pressure. Contrarily, around lake Lugano, the population dynamic is mostly affected by commuters or weekly workers, where the maximum pressure occurs during weekdays in all seasons (+6.6% average users presence than weekends). Results provide valuable input to further analyses connected, for example, to the correlation between human activities and lake-water quality and/or prediction models for anthropic pressure and tourism fluxes on lakes that are foreseen for the future development of this work.

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Lepori, Fabio, Camilla Capelli, and Danilo Foresti. "Changes in phytoplankton composition hinder the recovery from eutrophication in a perialpine lake (Lake Lugano, Switzerland and Italy)." Journal of Plankton Research 44, no. 1 (December 15, 2021): 22–35. http://dx.doi.org/10.1093/plankt/fbab083.

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Abstract We investigated the factors shaping the response of summer phytoplankton biomass to declining phosphorus (P) concentrations in a lake undergoing restoration (South basin of Lake Lugano, Switzerland and Italy). During 1989–2019, summer P concentrations declined from values typical of eutrophic lakes (>30 μg L−1) to values typical of mesotrophic lakes (10–30 μg L−1). Contrary to expectations, this decline was not followed by a decline in phytoplankton biomass. Instead, phytoplankton biomass showed the highest values in summers with lowest P concentrations. This paradoxical effect was associated with a change in phytoplankton composition. Higher P concentrations were associated with higher relative biomass of green algae, lower P concentrations with higher biomass of cyanobacteria and diatoms. We interpreted this change as a shift from edible and P-demanding phytoplankton to inedible and P-efficient phytoplankton, leading to different trophic structures. The pattern observed may be prompted by the particular conditions of deep lakes approaching mesotrophy, including occurrence of deep-water P reserves and high N concentrations, which can benefit inedible metalimnetic cyanobacteria. To attain reductions in summer phytoplankton biomass, restoration efforts may need to further reduce P concentrations and, possibly, address N enrichment.

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Lepori, Fabio, and Camilla Capelli. "Seasonal variation in trophic structure and restoration effects in a deep perialpine lake (Lake Lugano, Switzerland and Italy)." Journal of Great Lakes Research 46, no. 4 (August 2020): 870–80. http://dx.doi.org/10.1016/j.jglr.2019.12.008.

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Braschler, Martin, Linda Cappellato, Fabio Crestani, Nicola Ferro, Gundula Heinatz Bürki, David E. Losada, Henning Müller, Andreas Rauber, and Jacques Savoy. "Report on CLEF 2019." ACM SIGIR Forum 53, no. 2 (December 2019): 108–18. http://dx.doi.org/10.1145/3458553.3458571.

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This is a report on the tenth edition of the Conference and Labs of the Evaluation Forum (CLEF 2019), held from September 9--12, 2019, in Lugano, Switzerland. CLEF was a four day event combining a Conference and an Evaluation Forum. The Conference featured keynotes by Bruce Croft, Yair Neuman, and Miguel Martínez, and presentation of peer reviewed research papers covering a wide range of topics in addition to many posters. The Evaluation Forum consisted to nine Labs: CENTRE, CheckThat, eHealth, eRisk, ImageCLEF, LifeCLEF, PAN, PIR-CLEF, and ProtestNews, addressing a wide range of tasks, media, languages, and ways to go beyond standard test collections. CLEF 2019 marked the 20th anniversary of CLEF, which was celebrated with a dedicated session and a book on the lessons learnt in twenty years of evaluation activities and the future perspectives for CLEF. CLEF 2019 also introduced the Industry Days to further extend the reach and impact of CLEF.

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Rogerson, Pippa. "AUTONOMOUS CHARACTERISATION UNDER THE BRUSSELS I REGULATION RECAST." Cambridge Law Journal 76, no. 01 (March 2017): 22–25. http://dx.doi.org/10.1017/s0008197317000198.

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IN Arcadia Petroleum Ltd. v Bosworth [2016] EWCA Civ 818, three companies in the Arcadia Petroleum Group sued their de facto CEO and CFO and others in England for siphoning off money for their own benefit. One of the companies was incorporated in England, the others in Singapore and Switzerland. The companies claimed for unlawful means conspiracy, breach of fiduciary duty, dishonest assistance and knowing receipt. Could these claims all be litigated in England under the Lugano Convention, which allocates jurisdiction to determine disputes among the members of EFTA (the provisions at issue are identical to those of the Brussels I Regulation (No 44/2001) applicable in the EU)? The conclusion depended on whether the claims related to a contract of employment, or were contractual or were tortious. Each characterisation led to a different court with jurisdiction. The Court of Appeal held that mostly they could be litigated in England; only those for breach of fiduciary duty arising during the period of the directors' employment could not.

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Gaal, L., P. Molnar, and J. Szolgay. "Selection of intense rainfall events based on intensity thresholds and lightning data in Switzerland." Hydrology and Earth System Sciences Discussions 11, no. 1 (January 14, 2014): 593–628. http://dx.doi.org/10.5194/hessd-11-593-2014.

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Abstract. This paper presents a method to identify intense warm season storms of convective character based on intensity thresholds and lightning, and analyzes their statistical properties. Long records of precipitation and lightning data at 4 stations and 10 min resolution in different climatological regions in Switzerland are used. Our premise is that thunderstorms associated with lightning generate bursts of high rainfall intensity. We divided all storms into those accompanied by lightning and those without lightning and found the threshold I* that separates intense events based on peak 10 min intensity Ip ≥ I* for a chosen misclassification rate α. The performance and robustness of the selection method was tested by investigating the inter-annual variability of I* and its relation to the frequency of lightning strikes. The probability distributions of the main storm properties (rainfall depth R, event duration D, average storm intensity Ia and peak 10 min intensity Ip) for the intense storm subsets show that the event average and peak intensities are significantly different between the stations, and highest in Lugano in southern Switzerland. Non-parametric correlations between the main storm properties were estimated for the subsets of intense storms and all storms including stratiform rain. The differences in the correlations between storm subsets are greater than those between stations, which indicates that care must be exercised not to mix events when they are sampled for multivariate analysis, e.g. copula fitting to rainfall data.

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Sanna, Piero, Florian Strasser, and Hans Neuenschwander. "Highlights of the 4th San Salvatore Meeting on Palliative Care, Lugano and St. Gallen, Switzerland, 23–25 October 2001." Supportive Care in Cancer 10, no. 6 (August 6, 2002): 509–14. http://dx.doi.org/10.1007/s00520-002-0369-9.

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Blees, Jan, Helge Niemann, Christine B. Wenk, Jakob Zopfi, Carsten J. Schubert, Mathias K. Kirf, Mauro L. Veronesi, Carmen Hitz, and Moritz F. Lehmann. "Micro-aerobic bacterial methane oxidation in the chemocline and anoxic water column of deep south-Alpine Lake Lugano (Switzerland)." Limnology and Oceanography 59, no. 2 (January 27, 2014): 311–24. http://dx.doi.org/10.4319/lo.2014.59.2.0311.

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Gasparri, Maria Luisa, Ilary Ruscito, Filippo Bellati, Fabio Corsi, Rosa Di Micco, Oreste Davide Gentilini, Thorsten Kuehn, et al. "Abstract OT3-12-01: Immunological predictors of nodal response in breast cancer patients undergoing neoadjuvant therapy." Cancer Research 83, no. 5_Supplement (March 1, 2023): OT3–12–01—OT3–12–01. http://dx.doi.org/10.1158/1538-7445.sabcs22-ot3-12-01.

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Abstract Immunological predictors of nodal response in breast cancer patients undergoing neoadjuvant therapy Maria Luisa Gasparri1, Ilary Ruscito2, Filippo Bellati2, Fabio Corsi3, Rosa Di Micco4, Oreste D. Gentilini4, Thorsten Kuehn5, Andrea Papadia1, Donatella Caserta2, Lorenzo Rossi6, Arianna Calcinotto7 1 Department of Gynecology and Obstetrics, Ente Ospedaliero Cantonale, Ospedale Regionale di Lugano, Lugano, Switzerland 2 Department of Medical and Surgical Science and Translational Medicine, Sapienza University of Rome, Azienda Ospedaliera Sant’Andrea, Rome, Italy 3 Breast Unit, Department of Surgery, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy; Department of Biomedical and Clinical Sciences "Luigi Sacco", Università di Milano, Milan, Italy 4 Breast Surgery Unit, San Raffaele University Hospital, Milan, Italy 5 Interdisciplinary Breast Center, Department of Gynecology and Obstetrics, Klinikum Esslingen, Esslingen, Germany 6 Oncology Institute of Southern Switzerland, Bellinzona, Switzerland 7 Cancer Immunotherapy lab, IOR Institute of Oncology Research, Bellinzona, Switzerland Background: Almost 20% of breast cancer patients present at diagnosis with clinically positive nodes. Most of these patients undergo neoadjuvant therapy in order to de-escalate the axillary surgery in case of response (sentinel lymph node biopsy, targeted axillary dissection or targeted axillary dissection, instead of an axillary lymphadenectomy). The conversion from positive to negative nodes after neoadjuvant therpy is expected in approximately the 60% of the cases, depending by tumor subtypes. Several models have been proposed with the goal of identifying predictors of nodal response prior to neoadjuvant treatment. The immune system plays a pivotal role in cancer invasion and progression. Its role in treatment response is currently under investigation in several settings. Primary endpoint: to identify a preoperative immune profiling of breast cancer patients with nodal involvement at diagnosis and to correlate the immune changes after neoadjuvant therapy with the nodal response (macrometastases, micrometastasis, isolated tumor cells, complete response). Trial design: It is an international prospective cohort study including breast cancer patients undergoing standard neoadjuvant therapy, who present initially with biopsy-proven axillary lymph node metastasis. Ten immune markers will be analyzed using immunohistochemistry and tissue microarray in primary tumor and nodal tissue samples (tumor associated neutrophils, CD4 lymphocytes, CD8 lymphocytes, T regulatory cells, Macrophages, Follicular dendritic cells(DC), plasmocytoid DC, interdigitant DC, mature DC, Lysosomal associated membrane protein 3). The tissue analysis will be performed on the biopsy collected at diagnosis (prior to neoadjuvant therapy) and during the axillary surgery (after neoadjuvant therapy). Target accrual/sample size: 210 patients Statistical analysis: To compare the distribution of immune cells according to the state of lymph node metastasis, Student’s t test will be performed. Pearson’s chi-square test will be used to evaluate the correlation between immune profile and nodal response, based on clinic-pathological features. Odds ratios (ORs) and 95% confidence intervals (CIs) will be calculated using logistic regression analysis. Multivariable analysis will be performed using the multivariable logistic regression model. Logistic regression models will be used to identify the clinical, pathologic and immunological variables associated with the nodal response. P-values less than 0.05 will be considered significant. Analyses will be performed using Microsoft IBM SPSS® version 20.0 for Mac. Current status: Recruitment has not started yet. Contact information: marialuisa.gasparri@eoc.ch Citation Format: Maria Luisa Gasparri, Ilary Ruscito, Filippo Bellati, Fabio Corsi, Rosa Di Micco, Oreste Davide Gentilini, Thorsten Kuehn, Andrea Papadia, Donatella Caserta, Lorenzo Rossi, Arianna Calcinotto. Immunological predictors of nodal response in breast cancer patients undergoing neoadjuvant therapy [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr OT3-12-01.

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Ab-Kadir, Mohd. "Lightning severity in Malaysia and some parameters of interest for engineering applications." Thermal Science 20, suppl. 2 (2016): 437–50. http://dx.doi.org/10.2298/tsci151026028a.

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To the electric utility engineer, the parameters of the flash that are of primary interest are the crest current for the first and subsequent strokes, the waveshape of these currents, correlation between the parameters, the number of strokes per flash and flash incidence rates where the ground flash density, denoted as flashes per square km-year and symbolized by Ng. The first three parameters, as we know them today, are to a very large extent based on the measurements of Berger. Berger's masts, 70 and 80 meters high, were mounted atop Mt. San Salvatore (Switzerland), which is 650 meters above Lake Lugano, where it can be readily noted that these 125 records represent one of the best and most extensive set of data available to the industry to date. This paper focuses on the lightning severity scenario in Malaysia, which could also applicable to other tropic countries, and some of the useful parameters for lightning protection system design and forensic study. Some specific engineering applications have also been summarised, taking into account various lightning parameters, available from past and current measurements available.

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Carrion, D., E. Pessina, C. A. Biraghi, and G. Bratic. "CROWDSOURCING WATER QUALITY WITH THE SIMILE APP." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLIII-B4-2020 (August 24, 2020): 245–51. http://dx.doi.org/10.5194/isprs-archives-xliii-b4-2020-245-2020.

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Abstract. This paper aims at presenting the application for lake water quality monitoring which has been developed in the framework of SIMILE (Informative System for the Integrated Monitoring of Insubric Lakes and their Ecosystems) Interreg Italy-Switzerland project. The objective of SIMILE project is to facilitate the monitoring of the Maggiore, Como, and Lugano lakes through the integration of different techniques: in situ monitoring with buoys, remote sensing and citizen science. A mobile application has been designed in agreement with the project partners, who are also actors working for lake quality monitoring, such as CNR (Italian National Research Council) and ARPA (Agency for prevention and environmental protection). The developed application allows to collect data over the area of interest, such as pictures and parameters which can be acquired by visual inspection as well as with appropriate tools, depending on the user typology. The application has then been implemented with open source software to foster its use also for other projects with similar goals. In the paper, the design choices, the architecture and the implementation details are described.

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Lepori, Fabio, Maciej Bartosiewicz, Marco Simona, and Mauro Veronesi. "Effects of winter weather and mixing regime on the restoration of a deep perialpine lake (Lake Lugano, Switzerland and Italy)." Hydrobiologia 824, no. 1 (March 15, 2018): 229–42. http://dx.doi.org/10.1007/s10750-018-3575-2.

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Tu, Luyao, Klaus A. Jarosch, Tobias Schneider, and Martin Grosjean. "Phosphorus fractions in sediments and their relevance for historical lake eutrophication in the Ponte Tresa basin (Lake Lugano, Switzerland) since 1959." Science of The Total Environment 685 (October 2019): 806–17. http://dx.doi.org/10.1016/j.scitotenv.2019.06.243.

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Terrin, Jean-Jacques. "High Speed Railway Hubs in European Medium-Sized Cities: The Case of the ENTER.HUB Network." Open Transportation Journal 10, no. 1 (April 30, 2016): 119–23. http://dx.doi.org/10.2174/1874447801610010119.

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This contribution relates to the ENTER.HUB project implemented between 2012 and 2015 in the framework of the European URBACT II programme$. ENTER.HUB involved twelve medium-sized cities fitting into Trans-European Transport Networks (TENT-T) corridors, realizing or forecasting a High Speed Railway (HSR) Hub and planning multimodal interfaces of regional relevance. The ENTER.HUB project questioned the role of HSR Hubs in integrated urban development and in economic, social and cultural regeneration. The cities participating to ENTER.HUB network had in common to be in the process of redefining their territorial mobility systems, expecting that a Hub infrastructure would reinforce their links to other national and European cities, narrow their citizens and enterprises to diverse regional and interregional activities, and strength their connectivity from local to European level. The major objective of this project was to help these medium-sized cities to become more competitive and improve their mobility systems in connection with the HSR Hub to come. The twelve cities composing the ENTER HUB network are: Reggio Emilia (Italy), Lead Partner; IMPEFE - Ciudad Real (Spain); Creil Agglomeration (France); Gdynia (Poland); Girona (Spain); Łódź (Poland); Lugano (Switzerland); Örebro Region (Sweden); Porto (Portugal); Preston (UK); Rostock (Germany); Ulm (Germany).

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Gerosa, C., M. Bresciani, G. Luciani, C. A. Biraghi, D. Carrion, M. Rogora, and M. A. Brovelli. "ZONATION OF SUBALPINE LAKES BASED ON REMOTELY SENSED WATER QUALITY PARAMETERS." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLIII-B3-2021 (June 29, 2021): 551–58. http://dx.doi.org/10.5194/isprs-archives-xliii-b3-2021-551-2021.

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Abstract. SIMILE is an INTERREG Italy-Switzerland project that aims to preserve water quality of the subalpine lakes Como, Lugano and Maggiore (Northern Italy), through an integrated innovative monitoring system. For this purpose, satellite images are processed to map and monitor Chlorophyll-a (CHL-a), Total Suspended Solids (TSM) and Lake Water Surface Temperature (LWST). This study combines these remotely sensed water quality parameters (WPQs) maps, produced for the SIMILE project during 2019–2020, to propose and discuss a zonation approach that can support the monitoring of the study lakes through the analysis of spatial and temporal dynamics of the selected parameters. The approach consists in performing a cluster analysis on a combined sample of WQPs maps, on a monthly basis, for each lake; then the different lake clusters are compared over time, through time series analysis of the WQPs patterns. Finally, the clusters patterns are aggregated over time to map the lakes’ areas that have experienced higher or lower WQPs values during 2019–2020. The results show a high spatial variability for the lakes under study, both during the different seasons and years; a North-South gradient has been identified for all WQPs pattern, requiring for further investigation.

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Geminiani, Ludovico, Francesco Paolo Campione, Cristina Corti, Moira Luraschi, Sila Motella, Sandro Recchia, and Laura Rampazzi. "Differentiating between Natural and Modified Cellulosic Fibres Using ATR-FTIR Spectroscopy." Heritage 5, no. 4 (December 13, 2022): 4114–39. http://dx.doi.org/10.3390/heritage5040213.

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This paper presents the limitations and potential of ATR-FTIR spectroscopy applied to the study of cellulosic textile collections The technique helps to differentiate natural fibres according to the content of lignin, pectin, hemicellulose, and wax, although some problematic issues should be considered. The spectral differences derived from the environmental humidity uptake and the plant composition are reviewed and discussed in the light of new experimental data. Diagnostic bands are proposed that can discriminate between different fibres from different plants. The contribution of ageing is also considered, demonstrating that sometimes aged fibres cannot be reliably recognised. In contrast, the potential of ATR-FTIR spectroscopy to discriminate between natural and modified fibres is discussed and proven. The best results were obtained when microinvasive ATR-FTIR spectroscopy was coupled with SEM observations. The proposed protocol was tested on microsamples of various cellulosic materials from traditional Japanese samurai armours dating from the 16th to the 20th centuries (Morigi Collection, Museo delle Culture, Lugano, Switzerland). The results facilitated a complete characterisation of the materials and demonstrated that the protocol can be used to study a wide variety of cellulosic materials, including both natural and man-modified fibres, and paper.

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Castelnovo, A., R. Ferri, K. Tanioka, N. Tachibana, C. Carelli, G. Riccitelli, C. Zecca, C. Gobbi, and M. Manconi. "1122 Sleep Architecture and Leg Movement Activity During Sleep in Patients with Multiple Sclerosis." Sleep 43, Supplement_1 (April 2020): A427—A428. http://dx.doi.org/10.1093/sleep/zsaa056.1117.

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Abstract Introduction Although sleep in patients with Multiple Sclerosis (MS) has been investigated in several studies using subjective measures, objective sleep data collected using polysomnography (PSG) are still scanty and often divergent. We herein present the largest study to date evaluating sleep architecture and total leg movement activity during sleep (LMS) in patients with MS. Methods We collected PSG recordings from 80 patients affected by multiple sclerosis (MS, 48.1±10.61yo 67.5% females), and 60 age and gender matched healthy control subjects (HC, 48.5±17.20 yo, 56% females). Group differences were computed using non-parametric statistics for all traditional sleep architecture parameters, LMS, short-interval (SILMS), periodic (PLMS), isolated LMS (ISOLMS) indices and duration, inter-movement interval (IMI) graphs and time-of-night distribution of LMS. Results Patients with MS showed a significantly decreased total sleep period, an increased number of awakenings and stages shifts per hour of sleep, and an increased representation of stage 1 (min and %) compared to the HC group; 26 (32.5%) MS patients had PLMS ≥15/hour versus 8 (13.3%) HC subjects. On average, the comparison between MS and HC groups yielded significant results in terms of an increase in LMS, PLMS, SILMS and ISOLMS indices but not durations. Moreover, MS patients displayed a higher periodicity index, an increased PLMS activity at all inter-movement intervals considered and their PLMS time-of-night distribution revealed that the PLMS increase was stable over the course of the night. Conclusion Sleep continuity is significantly impaired in patients with MS. Moreover, MS patients also an increased total LMS activity, including PLMS, which may contribute to disrupt sleep continuity. A disinhibition of lower spinal network due to cervical or supraspinal MS lesions might be implicated in the mechanisms underlying this latter finding. Support The Employer Department of Neurology, Regional Hospital Lugano (EOC), Lugano, Switzerland receives financial support from Teva, Merck Serono, Biogen Idec, Bayer Schering, Genzyme, Roche and Novartis. The submitted work is not related to these agreements.

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Willey, A. Elwood. "International Conference on Fire-protection Halons and the Environment, held at the Palazzo dei Congressi, Lugano, Switzerland, during 28–29 June 1988." Environmental Conservation 15, no. 4 (1988): 373–74. http://dx.doi.org/10.1017/s0376892900030010.

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Canellos, G. P., J. Armitage, P. Ernst, A. Gianni, A. H. Goldstone, N. C. Gorin, T. Philip, G. Santini, and T. Takvorian. "Bone marrow transplantation in malignant lymphoma. Report of a workshop at the third international conference in lymphoma at Lugano, Switzerland, June 1987." Hematological Oncology 5, no. 4 (October 13, 2006): 295–98. http://dx.doi.org/10.1002/hon.2900050407.

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Cheson, Bruce D., Richard I. Fisher, Sally F. Barrington, Franco Cavalli, Lawrence H. Schwartz, Emanuele Zucca, and T. Andrew Lister. "Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification." Journal of Clinical Oncology 32, no. 27 (September 20, 2014): 3059–67. http://dx.doi.org/10.1200/jco.2013.54.8800.

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The purpose of this work was to modernize recommendations for evaluation, staging, and response assessment of patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). A workshop was held at the 11th International Conference on Malignant Lymphoma in Lugano, Switzerland, in June 2011, that included leading hematologists, oncologists, radiation oncologists, pathologists, radiologists, and nuclear medicine physicians, representing major international lymphoma clinical trials groups and cancer centers. Clinical and imaging subcommittees presented their conclusions at a subsequent workshop at the 12th International Conference on Malignant Lymphoma, leading to revised criteria for staging and of the International Working Group Guidelines of 2007 for response. As a result, fluorodeoxyglucose (FDG) positron emission tomography (PET)–computed tomography (CT) was formally incorporated into standard staging for FDG-avid lymphomas. A modification of the Ann Arbor descriptive terminology will be used for anatomic distribution of disease extent, but the suffixes A or B for symptoms will only be included for HL. A bone marrow biopsy is no longer indicated for the routine staging of HL and most diffuse large B-cell lymphomas. However, regardless of stage, general practice is to treat patients based on limited (stages I and II, nonbulky) or advanced (stage III or IV) disease, with stage II bulky disease considered as limited or advanced disease based on histology and a number of prognostic factors. PET-CT will be used to assess response in FDG-avid histologies using the 5-point scale. The product of the perpendicular diameters of a single node can be used to identify progressive disease. Routine surveillance scans are discouraged. These recommendations should improve evaluation of patients with lymphoma and enhance the ability to compare outcomes of clinical trials.

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Wautelet, Patrick R. "Swiss Bundesgericht, 26 September 1997, a Strong Incentive to the Litigants to Act Promptly." European Review of Private Law 9, Issue 1 (March 1, 2001): 81–92. http://dx.doi.org/10.54648/335689.

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When it comes to parallel proceedings in the European judicial area, Article 21 of the Brussels and the Lugano Conventions gives a strong incentive to the litigants to act promptly. By launching proceedings before the other party, one can block with a guillotine-like certainty all other proceedings between the same parties concerning the same dispute. Article 21 of the twin Conventions grants indeed priority to the court first seised in time. The present case shows that this 'crude but simple' rule - priority is given to one of the two courts seised not on account of its competence to deal with the particular litigation, or of its geographical proximity with the case - can give rise to a very sophisticated litigation strategy. In 1993 proceedings were launched both in Switzerland and in England in a dispute concerning liability for the losses incurred by an English company which had been placed under administration. The administrator threatened to sue three companies - two domiciled in Switzerland and one in New York - which were owned by the principal shareholder and managing director of the English company. According to the administrator, the three companies had illegaly benefited from the transfer by the director of assets from the English company. He granted the three companies 14 days to react and submit a comprehensive repayment plan. Two days before the end of this term, the three companies seised the Swiss court of a claim for a declaration that they were not liable for the money claimed. The day after these proceedings were issued, the administrator referred the matter to the English court. There ensued a conflict between the two parties as to the date on which an action is pending for the purposes of Article 21 (II). Before answering this vexed question, the Swiss Supreme Court had to determine whether the English and the Swiss proceedings were identical (I). While remaining true to the European nature of the lis pendens rule, the Court managed to curb certain abuses Article 21 can lead to. This decision will certainly make Switzerland less attractive for forum shoppers.

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Katsaprakakis, Kagiamis, Zidianakis, and Ambrosini. "Operation Algorithms and Computational Simulation of Physical Cooling and Heat Recovery for Indoor Space Conditioning. A Case Study for a Hydro Power Plant in Lugano, Switzerland." Sustainability 11, no. 17 (August 22, 2019): 4574. http://dx.doi.org/10.3390/su11174574.

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This article presents the computational simulation process and the operation algorithms of the VAV and VRV systems, for indoor space conditioning, with extensive physical cooling and heat recovery. Through the introduction of appropriate operation algorithms, the article aims to highlight the high energy saving potential on indoor space conditioning, by exploiting physical cooling and heat recovery processes. The proposed algorithms are evaluated with a case study for a hydro power plant building located in the area of Lugano, Switzerland, with significant cooling needs for the whole year, due to high internal heat gains from indoor electrical equipment. This fact enables physical cooling during winter, for the cooling load coverage, and heat recovery, for the concurrent heating load coverage in different thermal zones of the building. Analytical operation algorithms are developed for a VAV and a VRV system. Both algorithms are computationally simulated. With the VAV system, 86.1% and 63.7% of the annual cooling and heating demand, respectively are covered by physical cooling and heat recovery. With the VRV system, 58.5% of the annual heating demand is covered by heat recovery. The set-up cost of the VAV system is almost twice higher than the set-up cost of the VRV system.

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Geminiani, Ludovico, Francesco Paolo Campione, Cristina Corti, Sila Motella, Laura Rampazzi, Sandro Recchia, and Moira Luraschi. "Unveiling the Complexity of Japanese Metallic Threads." Heritage 4, no. 4 (October 28, 2021): 4017–39. http://dx.doi.org/10.3390/heritage4040221.

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In the framework of an extensive survey campaign on a collection of Japanese samurai armors, metallic threads from different parts of the traditional equipment were studied by several analytical techniques. The collection of armors belongs to Museo delle Culture (Lugano, Switzerland) and it is composed of ten elements, which date back from the 15th to 20th century. Metallic threads under study come from six of ten elements of the collection and represent a complex and unique multimaterial, which shows specific characteristics in Japanese tradition (kinran). The multianalytical approach based on ATR-FTIR (Attenuated Total Reflection-Fourier Transform Infrared) spectroscopy and SEM-EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray) analysis, together with a careful observation with optical and digital microscopy, permitted to obtain a complete characterization of materials, which have shown a great variability in metal foils and in organic adhesives (urushi, animal glue, starch). Gold and silver turned out to be not so largely used as scholars thought, while aluminum showed a great diffusion. Within the collection of analyzed armors, the obtained results allowed us for the first time to get a complete comprehension of materials and techniques used by Japanese craftsmen, and to observe differences in the quality of the materials and in manufacture technology over the centuries.

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Belliardi, Marco, Nerio Cereghetti, Paola Caputo, and Simone Ferrari. "A Method to Analyze the Performance of Geocooling Systems with Borehole Heat Exchangers. Results in a Monitored Residential Building in Southern Alps." Energies 14, no. 21 (November 7, 2021): 7407. http://dx.doi.org/10.3390/en14217407.

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Geothermal heat is an increasingly adopted source for satisfying all thermal purposes in buildings by reversible heat pumps (HP). However, for residential buildings located in moderate climates, geocooling, that implies the use of geothermal source for cooling buildings without the operation of HP, is an efficient alternative for space cooling not yet explored enough. Geocooling allows two main benefits: to cool the buildings by high energy efficiencies improving summer comfort; to recharge the ground if space heating is provided by HP exploiting the geothermal source (GSHP). In these cases, geocooling allows to avoid the decreasing of the performances of the GSHP for space heating over the years. To explore these issues, a method has been developed and tested on a real case: a new residential building in Lugano (southern Switzerland) coupled with 13 borehole heat exchangers. The system provides space heating in winter by a GSHP and space cooling in summer by geocooling. During a 40 months monitoring campaign, data such as temperatures, heat flows and electricity consumptions were recorded to calibrate the model and verify the benefits of such configuration. Focusing on summer operation, the efficiency of the system, after the improvements implemented, is above 30, confirming, at least in similar contexts, the feasibility of geocooling. Achieved results provides knowledge for future installations, underlining the replication potential and the possible limits.

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Journal articles on the topic 'Lugano (Switzerland)'

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