Dissertations / Theses on the topic 'LSRC'
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Engwirda, Anthony, and N/A. "Self-Reliance Guidelines for Large Scale Robot Colonies." Griffith University. Griffith School of Engineering, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20070913.100750.
Full textEngwirda, Anthony. "Self-Reliance Guidelines for Large Scale Robot Colonies." Thesis, Griffith University, 2007. http://hdl.handle.net/10072/368079.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Griffith School of Engineering
Faculty of Engineering and Information Technology
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Malheiros, Dorotea Starling. "Estudo descritivo do trauma ortopédico em crianças e adolescentes atendidas em centro de atendimento nível II." Universidade Federal de Minas Gerais, 2009. http://hdl.handle.net/1843/LSPC-8RWH9F.
Full textNo período de 27/04/1995 a 26/04/2005, estudou-se as vítimas de lesões de causa externa atendidas no Ambulatório de Ortopedia Pediátrica do Hospital Maria Amélia Lins. Os objetivos foram identificar as características das lesões ortopédicas; o perfil dos pacientes quanto às variáveis: idade, gênero, mecanismo de trauma, tipo de lesão, lado, localização topográfica e afecções associadas; e comparar os dados epidemiológicos com os da literatura. Foram critérios de inclusão ser vítimas de lesões de causa externa, a localização do prontuário, oregistro nele dos dados necessários à pesquisa, e a presença de fise aberta. No período, foram identificados 2472 pacientes, dos quais 1199 se encaixavam nos critérios de inclusão. Foram extraídos dos prontuários dados de identificação do paciente e dados relativos às lesões observadas. A variável idade foi registrada em números absolutos de anos de vida. Os mecanismos de trauma foram agrupados em acidentes de trânsito; quedas; trauma direto;outros e sem relato. Os tipos de lesões foram subdivididos em amputações; fraturas; epifisiólise; luxações; traumatismo cranioencefálico; contusões; lesões de órgãos internos; lesões de face; e outras lesões. As fraturas, fraturas-luxações, as epifisiólises e luxações foram classificadas, quanto à exposição, em expostas e fechadas. A localização topográfica das lesões foi classificada em relação aos segmentos ósseos nos quais ocorreram. Os pacientes foram agrupados em amostra geral, portadores de lesões isoladas e portadores de lesões múltiplas, considerando-se essas últimas as que acometeram mais de um segmento do esqueleto e/ou lesões de outros órgãos ou sistemas. A lesão musculoesquelética que necessitou mais atenção secundária foi descrita como lesão principal. Da amostra geral, 838 (68,9%) pacientes tiveram lesões isoladas e 361 (30,1%) presentaram 884 lesões. A média de idade foi 7,6±3,4 anos. Houve predomínio do gênero masculino e do lado esquerdo. Os membros superiores preponderaram nas lesões isoladas e os membros inferiores nas lesões múltiplas. O mecanismo de trauma mais comum na amostra geral e no grupo lesões isoladas foi a queda(39,0% e 44,3% respectivamente) e, nas lesões múltiplas, foi o acidente de trânsito (42,7%). O tipo de lesão mais frequente foi a fratura (73,0% - amostra geral, 85,3% - lesões isoladas e 61,1% - nas múltiplas). Quanto à localização topográfica, nas lesões isoladas predominaram asfraturas de cotovelo (24%) e, nas lesões múltiplas, as fraturas dos ossos da perna (12,9%). Nos portadores de lesões múltiplas, 67,1% tinham uma lesão associada, 24,3% duas, 5,3% três, e 3,3% quatro, com destaque para as fraturas de cotovelo com as fraturas de antebraço (25 casos). Concluiu-se que as características descritivas se encontram em conformidade com aliteratura. Os portadores de lesões isoladas podem ser definidos como meninos em idade escolar, vítimas de queda, apresentando fratura fechada de osso longo do membro superior. Os portadores de lesões múltiplas caracterizaram-se por ser meninos, em idade escolar, vítimas de acidente de trânsito apresentando fratura de ossos do membro inferior acompanhada de outra lesão. O desenvolvimento e a implantação de protocolos deatendimento são de fundamental importância para a eliminação de vieses na coleta de dados nesse tipo de estudo.
Zorzi, Giorgia. "Coordination and gapping in Catalan Sign Language (LSC)." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665045.
Full textAquesta tesi ofereix una descripció i una anàlisi sintàctica per a la coordinació i el “gapping” en coordinació conjuntiva en llengua de signes catalana (LSC), dins el marc generativista i minimista. Pel que fa a la coordinació, la categoria sintàctica que es proposa és “Coordination Phrase” (CoP) per a la coordinació conjuntiva, disjuntiva i adversativa. A l’estructura, ramificada a la dreta, els constituents de la conjunció són especificadors i complements de CoP. La derivació per a cada tipus de coordinació s’aplica a partir d’aquest model. Pel que fa al “gapping”, mostra proprietats similars a l’el·lipsi de SV (VP-ellipsis), sobretot perquè pot aparèixer en subordinació. A més, la l’existència només d’un abast distribuït de la negació (¬A&¬B) i la presència de tòpic i focus contrastius mostra la necessitat de tenir una coordinació “àmplia” on els dos conjunts siguin CPs. En la derivació de “gapping”, els arguments es mouen a TopP i FocP, seguits de l’eliminació del TP a PF, ambel tret [E] posicionat al nucli de FocP.
Cañas, Peña Sara. "Polar interrogatives in Catalan Sign Language (LSC): a comprehensive grammatical analysis." Doctoral thesis, Universitat Pompeu Fabra, 2021. http://hdl.handle.net/10803/670760.
Full textAquesta tesi ofereix una descripció morfosintàctica de les preguntes polars i una anàlisi pragmàtica de les preguntes esbiaixades en llengua de signes` catalana (LSC). Les preguntes polars en LSC es marquen obligatòriament amb una combinació específica de trets no manuals i, opcionalment, amb una partícula interrogativa. Ates que, si més no, el tret més destacat, la posició de les celles, no roman constant, l’LSC mostra diferents combinacions de no manuals per marcar aquesta estructura. L’evidencia científica dona suport a una anàlisi en què cadascuna de les combinacions de no manuals codifica un biaix diferent; un nou sistema de descripció basat en trets explica i prediu aquest comportament. Per tant, cada combinació de no manuals, així com l’aparició de la partícula interrogativa, es realitza no nomes per marcar el tipus d’oració, sinó també per codificar significats pragmàtics.
Esta tesis proporciona una descripción morfosintáctica de las preguntas polares y un analisis pragmático de las preguntas sesgadas en lengua de signos catalana (LSC). Las preguntas polares se marcan obligatoriamente con una combinacion específica de rasgos no manuales y opcionalmente con una partícula interrogativa. Dado que, al menos, el rasgo mas destacado, la posición de las cejas, no permanece constante, la LSC muestra diferentes combinaciones de no manuales para marcar esta estructura. La evidencia empírica sostiene un analisis en el que cada combinación de no manuales transmite un sesgo diferente; un novedoso sistema de descripcion basado en rasgos explica y predice esta conducta. Por ende, cada combinación de no manuales, así como la aparición de la partícula interrogativa, se realiza no solo para marcar el tipo de oración, sino también para codificar significados pragmáticos.
Navarrete-González, Alexandra. "Focus and contrast in Catalan Sign Language (LSC) : form and interpretation." Doctoral thesis, Universitat Pompeu Fabra, 2022. http://hdl.handle.net/10803/673320.
Full textAquesta tesi proporciona una descripció i una anàlisi pragmàtica de l’expressió i la interpretació del focus i el contrast en llengua de signes catalana (LSC). Defenso que l’LSC aporta proves empíriques que el contrast és una noció independent en el camp de l’estructura informativa que se solapa amb el tòpic i els focus de l’oració i que es pot dividir en subtipus que es conformen de manera composicional. Tots els tipus de contrast comparteixen un significat bàsic (paral·lelisme semàntic), que és imprescindible perquè un element sigui contrastiu i que s’expressa a través d’una combinació específica de marcadors no manuals (MNM). MNM addicionals són emprats per expressar significats més complexos, com ara l’exhaustivitat i la contraexpectació. A més, s’ofereix una primera descripció de les partícules focals i les oracions clivellades en LSC, i una anàlisi pragmàtica de l’exhaustivitat i el significat no veritatiu-condicional (implicatures i pressuposicions) que es deriva d’aquestes construccions.
Esta tesis proporciona una descripción y un análisis pragmático sobre la expresión y la interpretación del foco y el contraste en lengua de signos catalana (LSC). Defiendo que la LSC aporta pruebas empíricas de que el contraste es una noción independiente en el campo de la estructura informativa que se solapa con el tópico y el foco de la oración y que se puede dividir en subtipos que se constituyen de manera composicional. Todos los tipos de contraste comparten un significado básico (paralelismo semántico), que es imprescindible para que un elemento sea contrastivo y que se expresa a través de una combinación específica de marcadores no manuales (MNM). MNM adicionales son utilizados para expresar significados más complejos, como la exhaustividad y la contraexpectación. Además, se presenta una primera descripción de las partículas focales y de las oraciones escindidas en LSC, así como un análisis pragmático de la exhaustividad y del significado no veritativo-condicional (implicaturas y presuposiciones) que se deriva de estas construcciones.
Veiga, Busto Raquel. "Person and number in Catalan Sign Language pronouns." Doctoral thesis, Universitat Pompeu Fabra, 2022. http://hdl.handle.net/10803/673364.
Full textLes llengües utilitzen diferents recursos per a expressar el nombre dels referents i designar als participants en els actes de parla. Aquesta tesi descriu les estratègies morfofonològiques utilitzades als pronoms personals de la llengua de signes catalana (LSC) per a codificar aquestes distincions. En resum, es proposa que les categories de persona i nombre s’expressen utilitzant dues estratègies interrelacionades: la persona s’expressa a través de trets espacials (localitzacions a l’espai sígnic definides en relació amb el cos del parlant), el nombre es marca gramaticalment a través d’especificacions en la trajectòria del signe (moviments que connecten localitzacions espacials). La combinació d’aquestes dues operacions es tradueix en la codificació formal de tres distincions de persona (amb una oposició addicional entre exclusivitat, inclusivitat mínima i inclusivitat augmentada en la primera persona) i quatre valors de nombre (singular, dual, paucal i plural).
Las lenguas utilizan diferentes recursos para expresar el número de los referentes y designar a los participantes en el acto de habla. Esta tesis describe las estrategias morfofonológicas usadas en los pronombres personales de la lengua de signos catalana (LSC) para codificar estas distinciones. En síntesis, se propone que las categorías de persona y número se expresan utilizando dos estrategias interrelacionadas: la persona se expresa a través de rasgos espaciales (localizaciones en el espacio sígnico definidas en relación con el cuerpo del hablante), el número se marca gramaticalmente a través de especificaciones en la trayectoria del signo (movimientos que conectan localizaciones espaciales). La combinación de estas dos operaciones se traduce en la codificación formal de tres distinciones de persona (con una oposición adicional entre exclusividad, inclusividad mínima e inclusividad aumentada en la primera persona) y cuatro valores de número (singular, dual, paucal y plural).
Mesli, Samir. "Rôle du Lipolysis Stimulated Receptor (LSR) : expression chez la souris adulte et au cours de l'embryogénèse : conséquences de l'invalidation du gène LSR." Bordeaux 2, 2005. http://www.theses.fr/2005BOR21308.
Full textThe lipolysis stimulated receptor (LSR) recognizes apolipoprotein B/E-containing lipoproteins in the presence of free fatty acids, and is thought to be involved in the clearance of triglyceride-rich lipoproteins (TRL). The distribution of LSR in mice was studied by Northern blots, quantitative PCR and immunofluorescence. In the adult, LSR mRNA was detectable in all tissues except muscle and heart, and was abundant in liver, lung, intestine, kidney, ovaries and testes. During embryogenesis, LSR mRNA was detectable at 7. 5 days post-coitum (E7) and increased up to E17 in parallel to prothrombin, a liver marker. In adult liver, immunofluorescence experiments showed a staining at the periphery of hepatocytes as well as in fetal liver at E12 and E15. These results are in agreement with the assumption that LSR is a plasma membrane receptor involved in the clearance of lipoproteins by liver, and suggest a possible role in steroidogenic organs, lung, intestine and kidney. To explore the role of LSR in vivo, the LSR gene was inactivated in 129/Ola ES cells by removing a gene segment containing exons 2-5, and 129/Ola-C57BL/6 mice bearing the deletion were produced. Although heterozygotes appeared normal, LSR homozygotes were not viable, with the exception of three males, while the total progeny of genotyped wild-type and heterozygote pups was 376. Mortzality of the homozygote embryos was observed between days 12. 5 and 15. 5 of gestation, a time at which their liver was much smaller than that of their littermates, indicating that the expression of LSR is critical for liver and embryonic devellopment. To evaluate the effect of inactivation of one allele LSR in LDL receptor-deficient mice, we produce double knockout animals [LSR+/-] called LDLSR Total plasma cholesterol concentration were approximately 40 % less as compared with LDLR-/- mice These finding supported the hypothesis of upregulation of other receptors in LDLSR mice
Mosella, Sanz Marta. "Les construccions relatives en llengua de signes catalana (LSC)." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/123717.
Full textThis work contains the first description of Catalan Sign Language (LSC) Relative Clauses (RCs). Also, it proposes an analysis within the Generative framework that takes a typological approach. Regarding the syntactic typology of LSC RCs, they are circumnominal. In other words, they show the pivot (or antecedent) inside the RC. This contrasts with the most common RCs in Indo-European languages, the adnominal ones, in which the pivot appears outside the RC, that is, in the matrix clause. Other evidence that supports the idea that RCs in LSC are circumnominal is put forward. For instance, this structure shows a determiner that nominalizes the whole construction, as usually found in circumnominal RCs across languages. Circumnominal RCs in LSC never appear in its basic position inside the matrix clause. They have to appear or fronted or postposed to the matrix one. This same distribution is also found in other sign language RCs, for instance, in Italian Sign Language (LIS). The analysis presented here essentially follows the raising one (Kayne 1994). However, I have added some modifications in order to take into account crucial LSC data. The resulting analysis can be applied to the circumnominal construction as a whole, that is, in both oral and signed languages. To sum up, this work is a contribution to both typology and theoretical linguistics.
Ribera, i. Llonc Eulàlia. "La categoria verb en la llengua de signes catalana (LSC)." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/300741.
Full textThis thesis focuses on the identification and description of the category verb (V) in Catalan Sign Language (LSC). The research has been developed within the Borer’s theoretical framework (basically 2005a and 2005b), which has provided an approach to LSC different from the one typically found in previous descriptive studies. We describe the Lexical Functors (FL) and Functional Functors (FF) that we have identified for the category V in LSC in the corpus of our study. Following other investigations in sign languages, the present study starts with an analysis of a set of name-verb pairs in LSC, and we identify their morphophonological differences. At this level of morphophonological differences we distinguish two FL that assign an eventive structure to the root and identify it as V-equivalent. We also analyse the set of FF ( and independent f-morph) that may cause morphophonological changes in the verbalized root and contribute to identifying the category V. In this sense, the Functional Projections that are described in this thesis on the category V in LSC are: Agreement, Aspect, Manner and Quantity. Concerning Agreement, we analyse Person Agreement, Spatial Agreement and Number Agreement in LSC from a syntactic perspective. In contrast to most studies on Agreement in signed languages, we highlight the role of location as a part of the of the Person Agreement Functional Projection, even in roots classified as ‘plain roots’. We show that there is a hierarchical order that reflects Agreement with arguments and that depends on different syntactic structures. With respect to Aspect, we argue that ‘telicity’ and ‘atelicity’ are defined as Quantity, according to Borer (2005a,b), and that Aspect is built in syntax. Concerning the two FL identified for verbal roots, we show that one of them (FL1) assigns non-quantity eventive information to the verbalized root and the other (FL2#) a quantity one. We argue that this lexical eventive information is not crucial in syntax, first, because it can be modified, and, second, because verbalized roots can appear in different syntactic contexts, no matter which is its initial morphophonologycal information. Finally, in this study we show the need of a Manner Functional Projection and a Quantity Functional Projection (different from FL) to identify the category V in LSC. They both force a number of morphophonological changes in the V-equivalent roots and, consequently, they help to identify the category V. For each of them, we describe the relevant found in the corpus we have analysed, their different morphophonological realizations and the restrictions they may have.
Fisher, Matthew J. "The search for low scale technicolor in the Z + γ channel in 7 TeV ATLAS data." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343620633.
Full textPinault, Lucile. "Targeting Lsr2/DNA Complexation for Dysregulation of Gene Expression in Mycobacterium tuberculosis." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1365087235.
Full textCôté, Jean-Philippe. "L'héritage religieux du discours de la League for Social Reconstruction, LSR." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ60708.pdf.
Full textFujimoto, Shinji. "Beam commissioning and suppression of transverse coherent instability at S-LSR." 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/136765.
Full textLewis, Spenser M. "Simplified core physics and fuel cycle cost model for preliminary evaluation of LSCR fueling options." Thesis, Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51772.
Full textLee, Byeong-Seok. "Linear Switched Reluctance Machine Drives with Electromagnetic Levitation and Guidance Systems." Diss., Virginia Tech, 2000. http://hdl.handle.net/10919/29751.
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El, Hajj Aseel. "Rôle du LSR dans la régulation de l’homéostasie du cholestérol dans le système nerveux central." Electronic Thesis or Diss., Université de Lorraine, 2019. http://www.theses.fr/2019LORR0317.
Full textCholesterol is a crucial lipid in the central nervous system (CNS) and its strict regulation ensures proper neuronal development and function. Cholesterol is synthesized in the CNS by glial cells which produce and secrete cholesterol to meet neuronal needs. Lipoproteins and their receptors are key elements of this intercellular transport: where the latter recognize, bind and endocytose lipoproteins containing cholesterol. The lipolysis stimulated lipoprotein receptor (LSR) is the most recently discovered receptor in the CNS. It is a multimeric protein complex that undergoes conformational changes during the binding of free fatty acids, thus revealing a binding site which recognizes apolipoproteins B and E. Complete inactivation of the LSR gene is lethal at embryonic level, probably due to a leaky blood brain barrier. In addition, studies in LSR +/- mice have revealed a change in the distribution of cholesterol and cognitive functions. Our first goal was to perform LSR profiling at the tissue and cell level. Our results revealed a differential expression of the LSR subunits. In vitro studies in primary cell cultures have shown that LSR is highly expressed in different regions of the CNS, both in glial and neuronal cells. Our hypothesis was that a strong expression of LSR in glial cells could play a role in controlling the synthesis of cholesterol, by limiting the cholesterol circulating in the extracellular fluid of the brain. To verify this hypothesis, we have developed an inducible Cre-lox system specifically targeting glial cells. Behavioral phenotyping demonstrated a deficit in olfactory function which has an impact on the social memory of these animals. Although no visual problems were detected, the object recognition test showed that the visual memory was affected. Additionally, Y and Barnes mazes tests revealed an impacted short- and long-term memory. Our results suggest that specific inactivation of LSR in glial cells impairs animal memory, affecting spatial and social memory. Interestingly and similarly to AD, the early signs monitored olfactory deficits. Using a strategy combining behavioral phenotyping, immunostaining and biochemical analysis of specific markers of synaptic plasticity, this model could also be used to determine the role of LSR in brain cognition and cholesterol trafficking in the CNS, and could provide the means to validate LSR as a potential therapeutic target for the treatment of damage caused by lipid storage and the development of neurodegenerative diseases in the aging brain
Kertmen, Aykut. "Evaluation of the lLttoral Combat Ship (LSC) potential for the Turkish Navy." Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2006. http://library.nps.navy.mil/uhtbin/hyperion/06Sep%5FKertmen.pdf.
Full textThesis Advisor(s): Edward Fisher. "September 2006." Includes bibliographical references (p. 83-88). Also available in print.
Seehara, Panpailin. "Mixed-conducting LSC/CGO and Ag/CGO composites for passive seperation membranes." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517682.
Full textShirai, Toshiyuki. "One-dimensional beam ordering of protons at ion storage ring, S-LSR." 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/59310.
Full textKertmen, Aykut. "Evaluation of the Littoral Combat Ship (LSC) potential for the Turkish Navy." Thesis, Monterey California. Naval Postgraduate School, 2006. http://hdl.handle.net/10945/2625.
Full textDenis-Lagache, Nicolas. "Commutation ou extinction de l'expression du BCR et impact sur la cellule B." Thesis, Limoges, 2015. http://www.theses.fr/2015LIMO0071/document.
Full textAfter antigen recognition, B cells are activated and interact with other cells within secondarylymphoid organs (dendritic cells, T lymphocytes …) to form a germinal center. In the GC, the IgH locusis reorganized in order to increase the affinity of immunoglobulins for antigen through somatichypermutation (SHM) of V(D)J regions and to configure them into several forms harboring diversifiedmodes of action after “class switc recombination” (CSR). Both mechanisms are initiated by ActivationInduced Deaminase (AID) which targets DNA cytosines to convert them into uracil, then causing singleor double strand breaks in DNA when the mismatchs are located close to each other. It has been shownthat AID can target the IgH locus 3’ regulatory region on specific regions called LS, then leading to thetotal deletion of IgH locus C genes, loss of BCR expression and cell death by locus suicide recombination(LSR). In our study, we created a human Cμ knock-in model distal to the hs4 element of the 3’RR, in anattempt to rescue cells after the LSR event. Our model showed that this insertion indeed succeededinto replacing LSR by “class switching to humanized IgM” and also qualitatively modulated someaspects of the humoral response. This new LSR reporter model additionally supports the hypothesisthat LSR is regulated and increases with B cell activation. Studies of ex vivo B cells from the modelsuggest that LSR can occur in T dependent and independent manners, but is induced by triggering TLR4but not TLR9. Studies of the human IgM repertoire showed a biased use of VH families, and notably themouse VH5 family was used more frequently than in the control group. The BCR repertoire bias stronglysuggests that LSR is at least in part a matter of affinity of the BCR variable regions for antigens andligands that remain to be characterized
Danielsson, Johan, and Gustav Gistvik. "Estimation, model selection and evaluation of regression functions in a Least-squares Monte-Carlo framework." Thesis, Linköpings universitet, Produktionsekonomi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-110927.
Full textHagström, Adrian, and Rustam Stanikzai. "Writer identification using semi-supervised GAN and LSR method on offline block characters." Thesis, Högskolan i Halmstad, Akademin för informationsteknologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-43316.
Full textSeeharaj, Panpailin. "Mixed-conducting LSC/CGO and Ag/CGO composites for passive oxygen separation membranes." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5724.
Full textMasuda, Sayuri. "Angulin/LSR defines cell corners for tricellular tight junction formation in epithelial cells." Kyoto University, 2011. http://hdl.handle.net/2433/142056.
Full textReilly, Liam. "LSRP : defence styles, alexithymia, illness perceptions, and HRQOL in IBD ; Systematic lit : neurodegenerative diseases and third wave therapies." Thesis, Queen's University Belfast, 2018. https://pure.qub.ac.uk/portal/en/theses/lsrp-defence-styles-alexithymia-illness-perceptions-and-hrqol-in-ibd-systematic-lit-neurodegenerative-diseases-and-third-wave-therapies(15fb8a2d-8e69-4740-a18e-095c495b9cae).html.
Full textHu, Jiancheng. "Regulation of Lsc activity and role in B cell migration and antigen receptor signaling /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.
Find full textTypescript. Includes bibliographical references (leaves 103-118). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
Pinçon, Anthony. "Implication du récepteur LSR (lipolysis stimulated lipoprotein receptor) dans le contrôle de l’homéostasie du cholestérol cérébral et les capacités cognitives au cours du vieillissement." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0141/document.
Full textAlzheimer's disease (AD) is a neurodegenerative disease affecting millions of people. The origin of AD is multifactorial. Studies suggest that disturbance of cholesterol metabolism contributes to AD development. However, data in the literature is conflicting. It is therefore crucial to better characterize the metabolism and involvement of cholesterol in AD. This work focused on the Lipolysis Stimulated Lipoprotein Receptor (LSR), a hepatic lipoprotein receptor involved in the clearance of lipoproteins during the postprandial phase. The objectives of this thesis were to characterize LSR receptor expression profile in the mouse brain, and to determine its role in both brain cholesterol homeostasis and in the pathophysiology of AD. We identified and characterized LSR expression in brain structures that are involved in cognitive abilities and the regulation of energy metabolism. Next, using a mouse model heterozygous for the LSR receptor, we were able to demonstrate that the deletion of one allele LSR causes impaired brain cholesterol metabolism in aging, which was correlated with increased susceptibility to amyloid stress. These results suggest a role of LSR receptor in brain cholesterol homeostasis and show that alterations of the brain cholesterol metabolism can impact AD pathophysiology. Finally, we observed that the deficiency of an LSR allele in mice on a high fat diets affected peripheral lipid metabolism and the anxiety in these mice
Dalloul, Iman. "Switch Canonique en Cis ou Trans et Recombinaisons Suicides du Locus IgH." Thesis, Limoges, 2018. http://www.theses.fr/2018LIMO0049.
Full textB-cell activation is accompanied by remodeling of immunoglobulin genes resulting in affinity maturation of Ig variable regions by somatic hypermutation (SHM) and class switch recombination (CSR). These two processes are under the control of the 3' regulatory region (3’RR) of the IgH locus. During CSR, the IgH locus undergoes three dimensional changes bringing the AID-targeted switch regions near the 3'RR region to facilitate recombination. The MED1 subunit of the Mediator complex promotes this long-distance interaction with the 3'RR, but it is also implicated in germinal transcription preceding CSR in order to facilitate AID activity. As recently demonstrated in mice, the 3'RR region can also be targeted by AID-mediated recombination, but unlike CSR, this type of recombination joining the Sμ region and 3'RR (called Locus Suicide Recombination or LSR) results in a complete deletion of all the constant genes leading to B-cell death by loss of B Cell Receptor expression. We now show that AID-mediated LSR also occurs in activated human B cells with the two 3'RR (3'RR1downstream of Cα1 and 3'RR2 downstream of Cα2) and affects the functional allele. It can also be bi-allelic marked by the absence of this type of recombination in plasma cells of the bone marrow but also in quiescent blood memory B cells. LSR occurs at high level when the memory B cells are reactivated. All in-vitro stimulations induce LSR, without identifying conditions favoring either CSR and the LSR. Our results also show that the MED1 subunit appears to influence 3’ RR transcription and LSR in mice. Conditional inactivation of MED1 influences transcriptional accessibility and therefore recombination without affecting epigenetic markers of the IgH locus. This study also revealed that all the processes controlled by the 3'RR are "mediator -dependent" (SHM, CSR without distinction between Cis and Trans -CSR, increased expression of the IgH locus in the plasma cells ...), as well as the choice of varia ble segments during VDJH rearrangements
Xie, Ting. "Interactions épistatiques et modifications épigénétiques pour la stratification moléculaire des maladies chroniques." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0339/document.
Full textChronic diseases, like cardiovascular diseases (CVD), Alzheimer’s disease (AD), depression and osteoporosis, are major causes of mortality in the world. Identification of common to those diseases risk factors could help for a better-monitored ‘healthy’ aging, by promotion of personalised strategies for risk prediction, early prevention and adequate treatment, all taking into account the very often existing comorbidities. In this thesis, 8 publications have been developed. Initially, in a review paper, I have summarised the current challenges and opportunities of pharmacogenomics of CVD medications. I have participated in the formation of an international consortium, the VEGF Consortium, and I have participated in a study that identified significant epistatic interactions between polymorphisms that regulate the levels of VEGF and their effects on blood pressure and adiposity indexes. I have also demonstrated that one genetic marker of VEGF, rs4416670, was significantly associated with an increased risk for depression. Furthermore, I have reported two significant interactions between VEGF-related variants affecting the femoral neck bone mineral density in post-menopausal women. I have focused also on two markers linked with lipids metabolism: the apolipoprotein E (APOE) and the lipolysis-stimulated receptor (LSR). I have found that the LSR variant rs916147 can interact with APOE in a way that reverses the protective effect of the ε2 allele of APOE on blood lipids, thus providing new insights in the mechanisms underlying type III hyperlipoproteinemia. Epistatic interactions between these two genes have also been shown to increase the risk of AD, even in the absence of the known risk allele APOE ε4. Finally, I have performed epigenome-wide association studies (EWAS) on central obesity and blood lipid traits in healthy individuals. The results suggest that one methylation probe could affect waist circumference through an insulin-signaling pathway. Furthermore, two methylations probes were associated with triglycerides levels through genes linked with genetic heart diseases (PRKAG2) and with inhibition of the Wnt/beta-catenin signaling that is involved in CVD and AD development (KREMEN2). In conclusion, this thesis used the study of epistasis and epigenetics and identified complex inter-relationships between VEGF, LSR, APOE and different chronic diseases (CVD, AD, osteoporosis, depression) and novel mechanisms that link disease development with DNA methylation, thus demonstrating their role as common denominators of diseases that can be used as valuable markers in personalised medicine
Han, Cheng-Yu. "Clock Synchronization and Localization for Wireless Sensor Network." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS453/document.
Full textWireless sensor networks (WSNs) play an important role in applications such as environmental monitoring, source tracking, and health care,... In WSN, sensors have the ability to perform data sampling, distributed computing and information fusion. To perform such complex tasks, clock synchronization and localization are two fundamental and essential algorithms. WSNs have been widely studied in the past years, and the scientific literature reports many outcomes that make them applicable for some applications. For some others, research still needs to find solutions to some of the challenges posed by battery limitation, dynamicity, and low computing clock rate. With the aim of contributing to the research on WSN, this thesis proposes new algorithms for both clock synchronization and localization. For clock synchronization, sensors converge their local physical clock to perform data fusion. By applying the clock synchronization algorithm, sensors converge the time difference and therefore work at the same rate. In view of dynamicity, low computing and sparsity of WSN, a new pulse-coupled decentralized synchronization algorithm is proposed to improve the precision of the synchronization. The benefit of this kind of algorithm is that sensors only exchange zero-bit pulse instead of packets, so not only the communication is efficient but also robust to any failure of the sensors in the network. Localization of sensors has been widely studied. However, the quality and the accuracy of the localization still have a large room to improve. This thesis apply Leave-out Sign-dominant Correlated Regions (LSCR) algorithm to localization problem. With LSCR, one evaluates the accurate estimates of confidence regions with prescribed confidence levels, which provide not only the location but also the confidence of the estimation. In this thesis, several localization approaches are implemented and compared. The simulation result shows under mild assumptions, LSCR obtains competitive results compared to other methods
Barberà, Altimira Gemma. "The meaning of space in Catalan Sign Language (LSC). Reference, specificity and structure in signed discourse." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/81074.
Full textAquesta tesi se centra en l’ús de l’espai en llengua de signes catalana (LSC) a nivell discursiu. Defenso que les localitzacions no descriptives s’estableixen en els tres plans espacials i en descric els trets gramaticals. Les localitzacions espacials es representen morfofonològicament amb un punt abstracte a l’espai que no té una direcció específica en els plans espacials i que s’interpreta categòricament en el sistema lingüístic. En LSC, el pla frontal és gramaticalment important i denota especificitat: les localitzacions baixes correlacionen amb especificitat, mentre que les localitzacions altes correlacionen amb no especificitat. A més, la incorporació de l’estructura del discurs a l’anàlisi demostra que les localitzacions espacials baixes també denoten prominència discursiva. Les localitzacions espacials són, per tant, part de la gramàtica de la LSC i aquí les analitzo en relació al rol que tenen en l’expressió de l’especificitat i l’estructura discursiva. L’anàlisi s’emmarca en la formalització de la Discourse Representation Theory, tot basant-se en les dades d’un corpus en LSC a petita escala.
Hornuß, Daniel [Verfasser], and Klaus [Akademischer Betreuer] Aktories. "Untersuchungen zur Wechselwirkung zwischen dem C. difficile-Toxin CDT und seinem zugehörigen Zellrezeptor LSR an Plasmamembranen." Freiburg : Universität, 2014. http://d-nb.info/1123478481/34.
Full textWiechert, Johanna [Verfasser], Julia [Akademischer Betreuer] Frunzke, and Matias [Gutachter] Zurbriggen. "Silencing and counter-silencing of the Lsr2-like protein CgpS in Corynebacterium glutamicum / Johanna Wiechert ; Gutachter: Matias Zurbriggen ; Betreuer: Julia Frunzke." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1229191712/34.
Full textRajendran, Kaliaperumal. "The development and application of an analytical method for the determination of technetium-99 in the aquatic environment." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321830.
Full textXiaoyu, Dang, Zhang Yong, and Zhou Tingxian. "A METHOD TO ENHANCE THE BIT RATE OF LINEAR CODE GENERATOR IN SPREAD-SPECTRUM COMMUNICATION SYSTEM." International Foundation for Telemetering, 1999. http://hdl.handle.net/10150/607337.
Full textBecause of the limits of feedback devices, high-speed pseudo-noise code generators cannot depend simply on the improvement of clock rate. Based on the characteristic equation of linear feedback registers and the m-sequence sampling theory as well, deduction is made to indicate a novel way to improve the speed of pseudo-noise code generators 2^l (2^l < n, n is the length of registers) times as fast as the conventional one. Also, we extend our applications to non-reducible and non-primitive polynomials. It could be a good way to generate these linear codes at higher rates.
Kadir, Joanne, and Petra Forsberg. "Logistik och distribution ur ett hållbarhetsperspektiv : I vilken utsträckning läkemedelsföretag har LSR som en del i sitt övergripande hållbarhetsarbete." Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-417815.
Full textKiška, Martin. "Technologie MultiProtocol Label Switching v sítích Ethernet." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220653.
Full textAlsharairi, Naser Abdel Hamid Abdel Rahman. "Psychosocial Determinants of Food Choices among Australian Children: An Analysis of the Longitudinal Study of Australian Chiildren Database." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/365441.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Public Health
Griffith Health
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Chan, Gordon. "The role of Vav-1, Vav-2 and Lsc in NK T-cell development and NK cell cytotoxicity." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966206258.
Full textHanse, Marine. "Rôle du récepteur aux lipoprotéines, LSR, dans la régulation du transport et de la distribution des lipides alimentaires." Thesis, Vandoeuvre-les-Nancy, INPL, 2011. http://www.theses.fr/2011INPL086N/document.
Full textThe hepatic lipoprotein receptor LSR is involved in the clearance of triglyceride-rich lipoproteins including chylomicrons remnants during the post-prandial phase. Reduced LSR protein expression in mice (LSR+/-) is associated with dyslipidemia and increased postprandial lipemia; these mice exhibit increased weight gain with aging or when placed under a high-fat diet. In order to better understand the regulation of the distribution of dietary lipids, we looked for factors that could regulate LSR protein levels. Leptin is a hormone secreted by the adipose tissue that is a centrally-acting satiety factor, and was demonstrated to modulate LSR mRNA and protein expression through the modulation of transcription of the gene lsr. Leptin has been reported be involved in the control of lipogenesis through SREBP-1c. Using Garcinia cambogia extract containing an inhibitor of ATP citrate lyase, we demonstrated that there is an important link between lipogenic enzymes and LSR protein levels and with other lipoprotein receptors that provides the means to maintain a balance between endogenous lipid synthesis and dietary intake of exogenous lipids. When exogenous lipid intake is increased in the form of a high-fat diet, mice exhibited a decrease in hepatic lipogenic enzymes expression, but a deficiency of LSR led to increased lipid content in the peripheral tissues. These results suggest the presence of mechanisms for the maintenance for the balance between lipogenesis (de novo endogenous lipid synthesis), lipolysis (lipids used as energy substrate), and lipid storage through an important link between lipogenic enzymes and LSR
Mesquita, Fernanda Cristina de. "Efeito da liraglutida sobre a fibrose hep?tica e c?lulas estreladas ativadas." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2017. http://tede2.pucrs.br/tede2/handle/tede/7593.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
Liver fibrosis is the wound healing response to repeated injury of the liver. This process begins with the damage of the parenchymal cells and subsequent inflammation, characterized by the rupture of the hepatic architecture associated to the increase of the expression of the components of the extracellular matrix. The development of hepatic fibrosis is based on the activation of hepatic stellate cells (HSC) that undergo phenotypic changes and are characterized by loss of vitamin A deposition and increased cell proliferation, triggering hepatic microcirculatory dysfunction and fibrogenesis in patients with chronic liver disease (CLD). Liraglutide is a GLP-1 agonist (glucagon-like peptide 1) well established as an antidiabetic drug, but also has anti-inflammatory properties, in addition to the effectiveness for NAFLD (non-alcoholic fatty liver disease). Therefore, the aim of this study was to evaluate the effects of liraglutide on the HSC phenotype and liver microvascular function using diverse pre-clinical models of CLD. The results obtained demonstrate that Liraglutide de-activated human and rat HSC phenotype through a GLP1-Rindependent mechanism. Liraglutide did not affect the HSC viability but decreased cell proliferation. CLD-rats receiving liraglutide exhibited significantly lower portal pressure (-20%) with a consequent reduction in intrahepatic vascular resistance. There was also a marked improvements in hepatic vascular function, fibrosis, HSC phenotype and sinusoidal endothelial phenotype. The anti-fibrotic effects of liraglutide were confirmed in human liver tissue. In conclusion, this study demonstrates for the first time that liraglutide improves hepatic sinusoidal endothelium in clinically relevant experimental models of cirrhosis, which leads to improvement in fibrosis and portal hypertension, and therefore is valid in the treatment of advanced chronic liver disease.
A fibrose hep?tica ? a resposta cicatricial do f?gado ? les?es repetidas. Este processo inicia com o dano das c?lulas parenquimatosas e consecutiva inflama??o, caracterizado pelo rompimento da arquitetura hep?tica associada ao aumento da express?o dos componentes da matriz extracelular. O desenvolvimento da fibrose hep?tica ? baseado na ativa??o das c?lulas hep?ticas estreladas (HSC) que sofrem mudan?as fenot?picas e se caracterizam pela perda do dep?sito de vitamina A e aumento da prolifera??o celular, desencadeando disfun??o microcirculat?ria hep?tica e fibrog?nese nos pacientes com doen?a hep?tica cr?nica (CLD). A liraglutida ? um an?lago do GLP-1 (glucagon-like peptide 1) bem estabelecido como f?rmaco antidiab?tico, mas que tamb?m possui propriedades antinflamat?rias, al?m da efetividade para NAFLD (doen?a hep?tica gordurosa n?o alco?lica). Por essa raz?o, o objetivo deste estudo foi avaliar os efeitos da liraglutida sobre o fen?tipo das HSC e a fun??o microvascular hep?tica utilizando diversos modelos pr?-cl?nicos de CLD. Os resultados obtidos demonstram que a liraglutida desativou o fen?tipo das HSC humanas e de ratos atrav?s de um mecanismo independente do receptor GLP1. A liraglutida n?o afetou a viabilidade das HSC mas diminuiu a prolifera??o celular. Os ratos com CLD que receberam liraglutida apresentaram press?o portal significativamente menor (-20%) com consequente redu??o da resist?ncia vascular intra-hep?tica. Houve tamb?m uma acentuada melhoria na fun??o vascular hep?tica, fibrose, fen?tipo das HSC e fen?tipo endotelial sinusoidal. Os efeitos anti-fibr?ticos da liraglutida tamb?m foram confirmados em tecido hep?tico humano. Como conclus?o, este estudo demonstra pela primeira vez que a liraglutida melhora o endotelio sinusoidal hep?tico em modelos experimentais clinicamente relevantes de cirrose, o que leva a melhora no quadro fibr?tico e na hipertens?o portal e, portanto, pode ser v?lido no tratamento da doen?a hep?tica cr?nica avan?ada.
Williams, Kate Elizabeth. "Self-regulation from birth to age seven : associations with maternal mental health, parenting, and social, emotional and behavioural outcomes for children." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/71568/1/Kate_Williams_Thesis.pdf.
Full textHayes, Nicole. "Continuity and change in family engagement in home learning activities across the early years." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/84653/1/Nicole_Hayes_Thesis.pdf.
Full textSutanto, Taufik Edy. "Scalable fine-grained document clustering via ranking." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/107459/1/Taufik%20Edy_Sutanto_Thesis.pdf.
Full textHarkous, Ali. "Analyse du comportement thermo-rhéo-cinétique et de l’adhésion des silicones liquides." Nantes, 2015. http://archive.bu.univ-nantes.fr/pollux/show.action?id=de408d5c-1177-445f-bdc1-27f99ba483c1.
Full textThe Liquid Silicone Rubber (LSR) is a two-component elastomer that crosslinks at high temperature, its formulation can be adjusted depending on the application domain. The self-adhesive formulation of LSR allows its overmolding onto plastic parts through bi-material injection methods. In this study, the LSR-plastic overmolding is analyzed in industrial implementation conditions in order to identify the key factors influencing the adhesion quality. Initially, thermo-rheo-kinetic characterization of LSR allows us to understand the thermal and rheological behavior, and calculate the kinetic model that describes the material crosslinking process. The model and the measured parameters are used in the design of a mold dedicated for performing the LSR-plastic overmolding tests under controlled conditions. As such, the mold is instrumented and thermally controlled to simulate and reproduce the industrial implementation conditions. Thermocouples instrumentation is also integrated into the mold for in-situ detection of the LSR crosslinking reaction. It uses the modulation of signal method. Then, influential factors on the overmolding process are studied and presented in an experimental design. The overmolded parts are characterized by shear test to measure the adhesion criteria, including the breaking stress and the shear strain. The analysis of the results determines the influence of each factor on the quality of adhesion and computes the models that describe the phenomenon
Sandin, Måns. "Least Squares Monte Carlo-metoden & korgoptioner : En kvantitativ studie." Thesis, Umeå universitet, Institutionen för matematik och matematisk statistik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-159925.
Full textIn the banking and insurance industry, there exists a need for forecasting and measures of risk connecting to financial instruments. To create price distributions, used to create measures of risk, nested simulations are sometimes used. This is done by simulating a large amount of outer scenarios, for some asset in a financial instrument. Which is done by simulating prices over a certain time period. This now outlines the time horizon of the price distribution. From each outer scenario, some inner scenarios are simulated. Which in turn are used to price the financial instrument in the outer scenario. A common method for pricing the outer scenarios is the Monte Carlo method, which uses a large amount of random numbers for the pricing to be accurate. This makes the method time consuming, as well as requiring large amounts of computing power. The Least Squares Monte Carlo method is an alternative method, using regression and the least squares method to perform the pricing using a smaller amount of inner scenarios. A regression function is fitted to the values of the outer scenarios and then used to revalue these, reducing the error which a smaller number of random numbers otherwise would give. The regression function can also be used to price outside of the values used for the fitting, making it reusable in similar computations. This paper examines how well the Least Squares Monte Carlo-method describes the price distribution of basket options, which are options containing several underlying assets. Tests are made for different values for the parameters used and an emphasis is laid on the effect of the time length of the outer scenarios, also, how accurate the tails of the distribution are. The results are somewhat hard to analyze,due to some extreme values, but showed difficulties for the method, when pricing longer outer scenarios. This can be due to the regression function having problems fitting to - and valuing - broader price distributions. The method also performed worse in the lower parts of the distribution, something it shares with the standard Monte Carlo method. More research is needed to ascertain the effects of other regression functions.
Dalbom, Axel, and Tim Svensson. "Implementing the Load Slice Core on a RISC-V based microarchitecture." Thesis, Uppsala universitet, Datorarkitektur och datorkommunikation, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-424385.
Full textSiengchum, Tritti. "Electrochemical Oxidation of Methane on Ni-Doped Perovskite Anode Solid Oxide Fuel Cell." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1248205545.
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