Relevant bibliographies by topics / Lsr2

Academic literature on the topic 'Lsr2'

Author: Grafiati
Published: 7 July 2024
Last updated: 7 July 2024

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Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Journal articles on the topic "Lsr2":

1

Gordon, Blair R. G., Robin Imperial, Linru Wang, William Wiley Navarre, and Jun Liu. "Lsr2 of Mycobacterium Represents a Novel Class of H-NS-Like Proteins." Journal of Bacteriology 190, no. 21 (September 5, 2008): 7052–59. http://dx.doi.org/10.1128/jb.00733-08.

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ABSTRACT Lsr2 is a small, basic protein present in Mycobacterium and related actinomycetes. Our previous in vitro biochemical studies showed that Lsr2 is a DNA-bridging protein, a property shared by H-NS-like proteins in gram-negative bacteria. Here we present in vivo evidence based on genetic complementation experiments that Lsr2 is a functional analog of H-NS, the first such protein identified in gram-positive bacteria. We show that lsr2 can complement the phenotypes related to hns mutations in Escherichia coli, including β-glucoside utilization, mucoidy, motility, and hemolytic activity. We also show that Lsr2 binds specifically to H-NS-regulated genes and the repression of hlyE by Lsr2 can be partially eliminated by overexpression of slyA, suggesting that the molecular mechanisms of Lsr2 repression and depression are similar to those of H-NS. The functional equivalence of these two proteins is further supported by the ability of hns to complement the lsr2 phenotype in Mycobacterium smegmatis. Taken together, our results demonstrate unequivocally that Lsr2 is an H-NS-like protein.
2

Saini, Chaman, H. K. Prasad, Rajni Rani, A. Murtaza, Namita Misra, N. P. Shanker Narayan, and Indira Nath. "Lsr2 of Mycobacterium leprae and Its Synthetic Peptides Elicit Restitution of T Cell Responses in Erythema Nodosum Leprosum and Reversal Reactions in Patients with Lepromatous Leprosy." Clinical and Vaccine Immunology 20, no. 5 (February 27, 2013): 673–82. http://dx.doi.org/10.1128/cvi.00762-12.

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ABSTRACTThe Lsr2 protein ofMycobacterium lepraeand its synthetic peptides have been shown to elicit lymphoproliferation and gamma interferon (IFN-γ) release by peripheral blood mononuclear cells (PBMCs) of patients with lepromatous leprosy (M. Chaduvula, A. Murtaza, N. Misra, N. P. Narayan, V. Ramesh, H. K. Prasad, R. Rani, R. K. Chinnadurai, I. Nath, Infect. Immun. 80:742–752, 2012). PBMCs from 16 patients with lepromatous leprosy who were undergoing erythema nodosum leprosum (ENL) (type 2) and 5 patients with reversal reactions (RR) (type 1) were stimulated withM. leprae, recombinant Lsr2, and six end-to-end synthetic peptides (A through F) spanning the Lsr2 sequence. During the reaction all patients with ENL showed lymphoproliferation (stimulation index, >2) in response to peptides A and F, with other peptides eliciting responses in 75 to 88% of the subjects. In PBMC cultures, both lymphoproliferation and IFN-γ release for peptide E were significantly higher than for peptides B and C and recombinant Lsr2 (P< 0.05, Wilcoxon signed-rank test). Five patients with RR also showed enhanced lymphoproliferative responses and IFN-γ release in response to Lsr2,M. leprae, and peptide E. Six months postreaction, 14 patients with ENL continued to exhibit responses to Lsr2 and its peptides, with the highest responses being elicited by peptide E. However, 5 subjects showed no lymphoproliferation and had reduced IFN-γ release in response to Lsr2 peptides (P< 0.001, Kruskal-Wallis test) but responded to recombinant Lsr2. Six patients with ENL had HLA-A*68.01, which the STFPEITHI program showed to have high peptide-binding scores of 20 to 21 for peptides E, B, and C. Eleven patients had HLA-DRB1*1501 and HLA-DRB1*1502, which had high binding scores for peptides C and E. Thus, Lsr2 and its peptides are recognized in leprosy reactions during and well after the subsidence of clinical signs.
3

Pinault, Lucile, Jeong-Sun Han, Choong-Min Kang, Jimmy Franco, and Donald R. Ronning. "Zafirlukast Inhibits Complexation of Lsr2 with DNA and Growth of Mycobacterium tuberculosis." Antimicrobial Agents and Chemotherapy 57, no. 5 (February 25, 2013): 2134–40. http://dx.doi.org/10.1128/aac.02407-12.

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ABSTRACTThe mycobacterial nucleoid-associated protein Lsr2 is a DNA-bridging protein that plays a role in condensation and structural organization of the genome and acts as a global repressor of gene transcription. Here we describe experiments demonstrating that zafirlukast inhibits the complexation between Lsr2 and DNAin vitro. Zafirlukast is shown to inhibit growth in two different species of mycobacteria tested but exhibits no growth inhibition ofEscherichia coli. The Lsr2 inhibitory activity is reflectedin vivoas determined by monitoring of transcription levels inMycobacterium tuberculosis. These data suggest that zafirlukast inhibits Lsr2 functionin vivo, promoting dysregulation of the expression of an array of genes typically bound by Lsr2 and hindering growth. Since zafirlukast likely operates by a mechanism distinct from currentM. tuberculosisdrugs and is currently used as a prophylactic treatment for asthma, it offers an intriguing lead for development of new treatments for tuberculosis.
4

Chen, Jeffrey M., Greg J. German, David C. Alexander, Huiping Ren, Tracy Tan, and Jun Liu. "Roles of Lsr2 in Colony Morphology and Biofilm Formation of Mycobacterium smegmatis." Journal of Bacteriology 188, no. 2 (January 15, 2006): 633–41. http://dx.doi.org/10.1128/jb.188.2.633-641.2006.

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ABSTRACT The lipid-rich cell wall is a defining feature of Mycobacterium species. Individual cell wall components affect diverse mycobacterial phenotypes including colony morphology, biofilm formation, antibiotic resistance, and virulence. In this study, we describe a transposon insertion mutant of Mycobacterium smegmatis mc2155 that exhibits altered colony morphology and defects in biofilm formation. The mutation was localized to the lsr2 gene. First identified as an immunodominant T-cell antigen of Mycobacterium leprae, lsr2 orthologs have been identified in all sequenced mycobacterial genomes, and homologs are found in many actinomycetes. Although its precise function remains unknown, localization experiments indicate that Lsr2 is a cytosolic protein, and cross-linking experiments demonstrate that it exists as a dimer. Characterization of cell wall lipid components reveals that the M. smegmatis lsr2 mutant lacks two previously unidentified apolar lipids. Characterization by mass spectrometry and thin-layer chromatography indicate that these two apolar lipids are novel mycolate-containing compounds, called mycolyl-diacylglycerols (MDAGs), in which a mycolic acid (α- or α′-mycolate) molecule is esterified to a glycerol. Upon complementation with an intact lsr2 gene, the mutant reverts to the parental phenotypes and MDAG production is restored. This study demonstrates that due to its impact on the biosynthesis of the hydrophobic MDAGs, Lsr2 plays an important role in the colony morphology and biofilm formation of M. smegmatis.
5

Arora, Kriti, Danelle C. Whiteford, Dalia Lau-Bonilla, Christine M. Davitt, and John L. Dahl. "Inactivation of lsr2 Results in a Hypermotile Phenotype in Mycobacterium smegmatis." Journal of Bacteriology 190, no. 12 (April 11, 2008): 4291–300. http://dx.doi.org/10.1128/jb.00023-08.

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ABSTRACT Mycobacterial species are characterized by the presence of lipid-rich, hydrophobic cell envelopes. These cell envelopes contribute to properties such as roughness of colonies, aggregation of cells in liquid culture without detergent, and biofilm formation. We describe here a mutant strain of Mycobacterium smegmatis, called DL1215, which demonstrates marked deviations from the above-mentioned phenotypes. DL1215 arose spontaneously from a strain deficient for the stringent response (M. smegmatis ΔrelMsm strain) and is not a reversion to a wild-type phenotype. The nature of the spontaneous mutation was a single base-pair deletion in the lsr2 gene, leading to the formation of a truncated protein product. The DL1215 strain was complicated by having both inactivated relMsm and lsr2 genes, and so a single lsr2 mutant was created to analyze the gene's function. The lsr2 gene was inactivated in the wild-type M. smegmatis mc2155 strain by allelic replacement to create strain DL2008. Strain DL2008 shows characteristics unique from those of both the wild-type and ΔrelMsm strains, some of which include a greatly enhanced ability to slide over agar surfaces (referred to here as “hypermotility”), greater resistance to phage infection and to the antibiotic kanamycin, and an inability to form biofilms. Complementation of the DL2008 mutant with a plasmid containing lsr2 (pLSR2) reverts the strain to the mc2155 phenotype. Although these phenotypic differences allude to changes in cell surface lipids, no difference is observed in glycopeptidolipids, polar lipids, apolar lipids, or mycolic acids of the cell wall.
6

Seo, Jeong-Woo, Ki-Hyo Jang, Soon Ah Kang, Ki-Bang Song, Eun Kyung Jang, Buem-Seek Park, Chul Ho Kim, and Sang-Ki Rhee. "Molecular Characterization of the Growth Phase-Dependent Expression of the lsrA Gene, Encoding Levansucrase of Rahnella aquatilis." Journal of Bacteriology 184, no. 21 (November 1, 2002): 5862–70. http://dx.doi.org/10.1128/jb.184.21.5862-5870.2002.

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ABSTRACT Expression of the lsrA gene from Rahnella aquatilis, encoding levansucrase, is tightly regulated by the growth phase of the host cell; low-level expression was observed in the early phase of cell growth, but expression was significantly stimulated in the late phase. Northern blot analysis revealed that regulation occurred at the level of transcription. The promoter region was identified by primer extension analysis. Two opposite genetic elements that participate in the regulation of lsrA expression were identified upstream of the lsrA gene: the lsrS gene and the lsrR region. The lsrS gene encodes a protein consisting of 70 amino acid residues (M r, 8,075), which positively activated lsrA expression approximately 20-fold in a growth phase-dependent fashion. The cis-acting lsrR region, which repressed lsrA expression about 10-fold, was further narrowed to two DNA regions by deletion analysis. The concerted action of two opposite regulatory functions resulted in the growth phase-dependent activation of gene expression in Escherichia coli independent of the stationary sigma factor σS.
7

Gerges, Elias, Jean-Louis Herrmann, and Frédéric Crémazy. "Lsr2 : protéine associée au nucléoïde (NAP) et facteur transcriptionnel chez les mycobactéries." médecine/sciences 40, no. 2 (February 2024): 154–60. http://dx.doi.org/10.1051/medsci/2023218.

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Lsr2, une petite protéine conservée chez les actinobactéries, joue un rôle crucial dans la virulence et l’adaptation des mycobactéries aux conditions environnementales. Membre de la superfamille des protéines associées au nucléoïde (NAP), Lsr2 influence l’organisation de l’ADN en facilitant la formation de boucle chromosomique in vitro, ce qui suggère qu’elle pourrait être un acteur majeur du repliement tridimensionnel du génome. Lsr2 agit également comme un facteur de transcription, régulant l’expression de nombreux gènes responsables de la coordination d’une multitude de processus cellulaires et moléculaires essentiels chez les actinobactéries. Tout comme la protéine H-NS, son orthologue chez les entérobactéries, son rôle de répresseur transcriptionnel repose probablement sur son oligomérisation conduisant à la rigidification de l’ADN et, dans certaines situations, sur le pontage de fragments génomiques distants. Ces mécanismes pourraient perturber le recrutement de l’ARN polymérase sur les promoteurs ainsi que l’élongation des transcrits.
8

Li, Yakun, Yuyun Wei, Xiao Guo, Xiaohui Li, Lining Lu, Lihua Hu, and Zheng‐Guo He. "Insertion sequence transposition activates antimycobacteriophage immunity through an lsr2‐silenced lipid metabolism gene island." mLife 3, no. 1 (March 2024): 87–100. http://dx.doi.org/10.1002/mlf2.12106.

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AbstractInsertion sequences (ISs) exist widely in bacterial genomes, but their roles in the evolution of bacterial antiphage defense remain to be clarified. Here, we report that, under the pressure of phage infection, the IS1096 transposition of Mycobacterium smegmatis into the lsr2 gene can occur at high frequencies, which endows the mutant mycobacterium with a broad‐spectrum antiphage ability. Lsr2 functions as a negative regulator and directly silences expression of a gene island composed of 11 lipid metabolism‐related genes. The complete or partial loss of the gene island leads to a significant decrease of bacteriophage adsorption to the mycobacterium, thus defending against phage infection. Strikingly, a phage that has evolved mutations in two tail‐filament genes can re‐escape from the lsr2 inactivation‐triggered host defense. This study uncovered a new signaling pathway for activating antimycobacteriophage immunity by IS transposition and provided insight into the natural evolution of bacterial antiphage defense.
9

Nguyen, Kiet T., Kristina Piastro, Todd A. Gray, and Keith M. Derbyshire. "Mycobacterial Biofilms Facilitate Horizontal DNA Transfer between Strains of Mycobacterium smegmatis." Journal of Bacteriology 192, no. 19 (July 30, 2010): 5134–42. http://dx.doi.org/10.1128/jb.00650-10.

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ABSTRACT Conjugal transfer of chromosomal DNA between strains of Mycobacterium smegmatis occurs by a novel mechanism. In a transposon mutagenesis screen, three transfer-defective insertions were mapped to the lsr2 gene of the donor strain mc2155. Because lsr2 encodes a nonspecific DNA-binding protein, mutations of lsr2 give rise to a variety of phenotypes, including an inability to form biofilms. In this study, we show that efficient DNA transfer between strains of M. smegmatis occurs in a mixed biofilm and that the process requires expression of lsr2 in the donor but not in the recipient strain. Testing cells from different strata of standing cultures showed that transfer occurred predominantly at the biofilm air-liquid interface, as other strata containing higher cell densities produced very few transconjugants. These data suggest that the biofilm plays a role beyond mere facilitation of cell-cell contact. Surprisingly, we found that under standard assay conditions the recipient strain does not form a biofilm. Taking these results together, we conclude that for transfer to occur, the recipient strain is actively recruited into the biofilm. In support of this idea, we show that donor and recipient cells are present in almost equal numbers in biofilms that produce transconjugants. Our demonstration of genetic exchange between mycobacteria in a mixed biofilm suggests that conjugation occurs in the environment. Since biofilms are considered to be the predominant natural microhabitat for bacteria, our finding emphasizes the importance of studying biological and physical processes that occur between cells in mixed biofilms.
10

Deng, Lina, Rui Wang, Guowei Wang, Mingxu Liu, Guojian Liao, Zhihua Liao, and Min Chen. "Targeted isolation of sulfur-containing metabolites from Lsr2-deletion mutant strain of Streptomyces roseosporus." RSC Advances 7, no. 60 (2017): 37771–77. http://dx.doi.org/10.1039/c7ra06482a.

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Journal articles Dissertations / Theses Books

Dissertations / Theses on the topic "Lsr2":

1

Pinault, Lucile. "Targeting Lsr2/DNA Complexation for Dysregulation of Gene Expression in Mycobacterium tuberculosis." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1365087235.

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Gerges, Elias. "Caractérisation du rôle de la protéine Lsr2 dans la virulence des morphotypes lisse (S) et rugueux (R) de Mycobacterium abscessus." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL131.

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Mycobacterium abscessus (Mabs) est une mycobactérie non tuberculeuse à croissance rapide, qui provoque des infections pulmonaires chez les patients atteints de mucoviscidose. Au cours de l'infection, Mabs évolue entre un morphotype lisse (Mabs-S) et un morphotype rugueux (Mabs-R), ce dernier étant hyper-virulent. Notre équipe a précédemment identifié le gène lsr2 comme étant différentiellement exprimé pendant la transition de Mabs-S à Mabs-R. lsr2 code pour un facteur de transcription pléiotropique qui appartient à la superfamille des protéines associées aux nucléoïdes (NAPs), lesquelles jouent un rôle clé dans la structure du chromosome bactérien. L'objectif de cette thèse est d'élucider le rôle moléculaire de Lsr2 dans la pathobiologie de Mabs en utilisant trois approches de génomique fonctionnelle : RNA-seq, ChIP-seq et Hi-C. L'analyse transcriptomique révèle que Lsr2 régule différemment l'expression des gènes dans les deux morphotypes, dont la plupart sont impliqués dans divers processus cellulaires clés de Mabs, notamment l'adaptation à l'hôte et la résistance aux antibiotiques. Ces résultats ont été confirmés par RT-qPCR, ainsi que par des tests de concentration minimale inhibitrice (CMI) et des tests d'infection sur des macrophages en présence d'antibiotiques. L'analyse ChIP-seq montre que Lsr2 se lie largement au génome de Mabs (10%) au niveau de séquences riches en AT et semble former de longs domaines par oligomérisation qui participent à la répression de ses gènes cibles. Cependant, la similitude de fixation de Lsr2 entre Mabs-S et Mabs-R et la présence d'un grand nombre de gènes liés mais non régulés suggèrent que des mécanismes plus complexes, tels que le pontage d'ADN, pourraient être impliqués pour assurer la sélectivité des gènes cibles. Dans le cadre de cette thèse, nous avons développé un protocole Hi-C pour étudier la structure tridimensionnelle du chromosome de Mabs. Ce travail a également impliqué la mise en place de la technique 3C-qPCR pour analyser les interactions physiques dépendantes de la protéine Lsr2 entre les fragments d'ADN. Ces avancées méthodologiques ouvrent de nouvelles perspectives pour la compréhension de la régulation génomique chez Mabs
Mycobacterium abscessus (Mabs) is a non-tuberculous mycobacterium, causing lung infections in cystic fibrosis patients. During infection, Mabs switches from smooth (Mabs-S) to rough (Mabs-R) morphotypes, the latter being hyper-virulent. Our team previously identified the gene lsr2 as being differentially expressed during the transition from Mabs-S to Mabs-R. lsr2 codes for a pleiotropic transcription factor that belongs to the superfamily of nucleoid-associated proteins (NAPs), which play a key role in the structure of bacterial chromosome. The objective of this thesis is to elucidate the molecular role of Lsr2 in the pathobiology of Mabs using three functional genomics approaches: RNA-seq, ChIP-seq, and Hi-C. Transcriptomic analysis reveals that Lsr2 differentially regulates gene expression in both morphotypes, with most genes being involved in various key cellular processes of Mabs, including adaptation to the host and antibiotic resistance. These results were confirmed through RT-qPCR, as well as by minimum inhibitory concentration (MIC) tests and infection tests on macrophages in the presence of antibiotics. ChIP-seq analysis revealed that Lsr2 extensively binds the Mabs genome at AT-rich sequences and appears to form long domains through oligomerization that participate in the repression of its target genes. However, the similarity in Lsr2 binding between Mabs-S and Mabs-R, and the presence of a large number of bound genes but unregulated suggest that more complex mechanisms, such as DNA bridging, may be involved in ensuring gene target selectivity. As part of this thesis, we developed a Hi-C protocol to study the three-dimensional structure of the Mabs chromosome. This work also involved the implementation of the 3C-qPCR technique to analyze Lsr2-dependent physical interactions between DNA fragments. These methodological advances open up new perspectives for understanding genomic regulation in Mabs
3

Wiechert, Johanna [Verfasser], Julia [Akademischer Betreuer] Frunzke, and Matias [Gutachter] Zurbriggen. "Silencing and counter-silencing of the Lsr2-like protein CgpS in Corynebacterium glutamicum / Johanna Wiechert ; Gutachter: Matias Zurbriggen ; Betreuer: Julia Frunzke." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1229191712/34.

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STOTANI, SILVIA. "Design and synthesis of LsrK kinase inhibitors as Quorum Sensing modulators." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1251369.

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STOTANI, SILVIA. "Design and synthesis of LsrK kinase inhibitors as Quorum Sensing modulators." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1251389.

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STOTANI, SILVIA. "Design and synthesis of LsrK kinase inhibitors as Quorum Sensing modulators." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1251409.

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STOTANI, SILVIA. "Design and synthesis of LsrK kinase inhibitors as Quorum Sensing modulators." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1277366.

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STOTANI, SILVIA. "Design and synthesis of LsrK kinase inhibitors as Quorum Sensing modulators." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1277807.

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STOTANI, SILVIA. "Design and synthesis of LsrK kinase inhibitors as Quorum Sensing modulators." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1281046.

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STOTANI, SILVIA. "Design and synthesis of LsrK kinase inhibitors as Quorum Sensing modulators." Doctoral thesis, Università degli studi di Pavia, 2019. http://hdl.handle.net/11571/1280626.

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Books on the topic "Lsr2":

1

Chubb, Donald L. Scaling results for the liquid sheet radiator (LSR). [Washington, DC]: National Aeronautics and Space Administration, 1989.

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L, Chubb Donald, and United States. National Aeronautics and Space Administration., eds. Design considerations for space radiators based on the liquid sheet (LSR) concept. [Washington, DC]: National Aeronautics and Space Administration, 1991.

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Begines, Juan Luis Pulido. El derecho de información del socio en la Sociedad de Responsabilidad Limitada: Arts. 51 y 86 LSRL. Madrid: Editorial Civitas, 1997.

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Linguistic Symposium on Romance Languages (39th 2009 Tucson, Arizona). Romance linguistics 2009: Selected papers from the 39th linguistic symposium on romance languages (LSRL), Tucson, Arizona, March 2009. Amsterdam: John Benjamins Pub. Co.., 2010.

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Linguistic Symposium on Romance Languages (32nd : 2002 : Toronto, Ont.). Romance linguistics: Theory and acquisition : selected papers from the 32nd Linguistic Symposium on Romance Languages (LSRL), Toronto, April 2002. Amsterdam: John Benjamins, 2003.

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Linguistic Symposium on Romance Languages (32nd 2002 Toronto, Ont.). Romance linguistics: Theory and acquisition : selected papers from the 32nd Linguistic Symposium on Romance Languages (LSRL), Toronto, April 2002. Amsterdam: J. Benjamins, 2003.

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Linguistic, Symposium on Romance Languages (35th 2005 Austin Tex ). New perspectives on Romance linguistics: Selected papers from the 35th Linguistic Symposium on Romance Languages (LSRL), Austin, Texas, February 2005. Amsterdam: John Benjamins, 2006.

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Linguistic Symposium on Romance Languages (33rd 2003 Bloomington, Ind.). Contemporary approaches to Romance linguistics: Selected papers from the 33rd Linguistic Symposium on Romance Languages (LSRL), Bloomington, Indiana, April 2003. Amsterdam: J. Benjamins, 2004.

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Linguistic Symposium on Romance Languages. Contemporary approaches to Romance linguistics: Selected papers from the 33rd Linguistic Symposium on Romance Languages (LSRL), Bloomington, Indiana, April 2003. Amsterdam: John Benjamins, 2000.

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N.Y.) Linguistic Symposium on Romance Languages (43rd 2013 New York. Romance linguistics 2013: Selected papers from the 43rd Linguistic Symposium on Romance Languages (LSRL), New York, 17-19 April, 2013. Amsterdam: John Benjamins Publishing Company, 2015.

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Book chapters on the topic "Lsr2":

1

McIntire, John, Caroline Bosire, and Tim Robinson. "African livestock systems research, 1975-2018." In The impact of the International Livestock Research Institute, 515–600. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789241853.0515.

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Abstract Livestock systems research (LSR) at the International Livestock Research Institute (ILRI) sought to answer two questions: (1) What are the major livestock systems in the sub-Saharan Africa tropics and subtropics? (2) What technical and organizational changes can be introduced into these systems to make them productive? This chapter reports the answers of decades of research at ILRI, its predecessors and its principal partners to these questions. The chapter also examines the scientific and development impacts of LSR since the 1970s, and whether the development impacts of LSR be distinguished from long-term trends in African livestock systems.
2

Danared, Håkan, Anders Källberg, and Ansgar Simonsson. "CRYRING at the LSR at FLAIR." In EXA/LEAP 2008, 477–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-02803-8_69.

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Vasanthan, R., and R. Nandhini. "Integrating the Sub-Skills of LSRW for ESL Learners." In Contemporary ELT Strategies in Engineering Pedagogy, 95–116. London: Routledge India, 2022. http://dx.doi.org/10.4324/9781003268529-9.

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Hiltrud Dave Eve, P. "Teaching LSRW Skills through the Test, Teach, Test (TTT) Method." In Contemporary ELT Strategies in Engineering Pedagogy, 83–94. London: Routledge India, 2022. http://dx.doi.org/10.4324/9781003268529-8.

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Chen, Jintai, Yanjie Wang, Ruoqian Guo, Bohan Yu, Tingting Chen, Wenzhe Wang, Ruiwei Feng, Danny Z. Chen, and Jian Wu. "LSRC: A Long-Short Range Context-Fusing Framework for Automatic 3D Vertebra Localization." In Lecture Notes in Computer Science, 95–103. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-32226-7_11.

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Park, Bok-Nyong, Jihoon Myung, and Wonjun Lee. "LSRP: A Lightweight Secure Routing Protocol with Low Cost for Ad-Hoc Networks." In Information Networking. Convergence in Broadband and Mobile Networking, 160–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/978-3-540-30582-8_17.

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Topal, Cihan, and Cuneyt Akinlar. "Implementing IPv4+4 Addressing Architecture with IPv4 LSRR Option for Seamless Peer-to-Peer (P2P) Communication." In Parallel and Distributed Processing and Applications, 809–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-74742-0_72.

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Baharom, M. B., Salah E. Mohammed, Najaf Hussain, A. Rashid A. Aziz, Z. Ezrann A. Zainal, and Mhadi A. Ismael. "A Study on the Effect of Structural Properties and Configuration of Low-Stiffness-Resilient-Shaft (LSRS) on Torsional Behavior." In Lecture Notes in Mechanical Engineering, 995–1011. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-1939-8_74.

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Moal, E., J. Seifert, and K. Rädlinger. "Comparison of Laboratory Test, Field Station and Service Performance of HTV and LSR Hollow Core Housings." In Lecture Notes in Electrical Engineering, 459–71. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-31680-8_47.

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Wang, Jiagang, Tu Qian, Anbang Yang, Hui Wang, and Jiangbo Qian. "LSR-Forest: An LSH-Based Approximate k-Nearest Neighbor Query Algorithm on High-Dimensional Uncertain Data." In Communications in Computer and Information Science, 167–77. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-2810-1_17.

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Conference papers on the topic "Lsr2":

1

Brown, David C., and Scott J. Hamlin. "Neodymium Laser-Pumped Ytterbium-Activated Erbium-Doped Phosphate Glass Laser." In Advanced Solid State Lasers. Washington, D.C.: OSA, 1991. http://dx.doi.org/10.1364/assl.1990.lsr2.

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Goncharov, A. A., and O. Yu Inkova. "IMPLICIT LOGICAL-SEMANTIC RELATIONS AND A METHOD OF THEIR IDENTIFICATION IN PARALLEL TEXTS." In International Conference on Computational Linguistics and Intellectual Technologies "Dialogue". Russian State University for the Humanities, 2020. http://dx.doi.org/10.28995/2075-7182-2020-19-310-320.

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Abstract:
One of the main characteristics of logical-semantic relations (LSRs) between two fragments of a text is that these relations can be either explicit (expressed by some marker, e.g. a connective) or implicit (derived from the interrelation of these fragments’ semantics). Since implicit LSRs do not have any marker, it is difficult to find them in a text (whether automatically or not). In this paper, approaches to analysing implicit LSRs are compared, an original definition for them is offered and differences between implicit LSRs and LSRs expressed by non-prototypical means are described. A method is proposed to identify implicit LSRs using a parallel corpus and a supracorpora database of connectives. Based on the well-known statement that LSRs can be explicitated by adding connectives in the translation, it is argued here that through selecting pairs in which fragments where a connective is used to express an LSR in the translation correspond to those containing any of the translation stimuli standard for this connective in the source language, it is possible to get an array of contexts in which this LSR is implicit in the source text (or expressed by means other than connectives). This method is then applied to study the French causal connectives car, parce que and puisque using a Russian-French parallel corpus. The corpus data are analysed to obtain information about LSRs particularly about cases where the causal LSR in Russian is implicit, as well as about the use of causal connectives in French. These results are used to show that the method proposed allows to quickly create a representative array of contexts with implicit LSRs, which can be useful in both text analysis and in machine learning.
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Ye, Tao, Danny Bickson, Nicholas Ampazis, and Andras Benczur. "LSRS'15." In RecSys '15: Ninth ACM Conference on Recommender Systems. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2792838.2798715.

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Ye, Tao, Denis Parra, Vito Ostuni, and Tao Wang. "LSRS'17." In RecSys '17: Eleventh ACM Conference on Recommender Systems. New York, NY, USA: ACM, 2017. http://dx.doi.org/10.1145/3109859.3109970.

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Ye, Tao, Danny Bickson, and Denis Parra. "LSRS'16." In RecSys '16: Tenth ACM Conference on Recommender Systems. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2959100.2959206.

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Hashemi, Saeed, Steven Sobojinski, and William K. Durfee. "Low-Friction Antagonist Hydraulic Transmission Using Long-Stroke Rolling Diaphragm Cylinders." In ASME/BATH 2017 Symposium on Fluid Power and Motion Control. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/fpmc2017-4348.

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Hydraulic cylinders are the most common actuators for small, passive hydraulic systems. Friction and leakage of the actuators are the most crucial factors for force and volume efficiency. Development of a frictionless and leak-free cylinder would enable implementation of a passive human body controlled device. Due to the limitation of short stroke length in commercial rolling diaphragm (RD) cylinders, a novel fabric-elastomer long-stroke rolling diaphragm (LSRD) cylinder was developed, evaluated, and compared to the commercial rolling diaphragm, O-ring, and gap seal cylinders. The LSRD cylinder has low friction, zero leakage, and can operate at up to 700 kPa (100 psi). The performance of the LSRD cylinders was evaluated using an antagonist hydraulic transmission benchtop device. Axial motion of the LSRD cylinders was converted to a rotary motion on the input and output shafts using timing belts and pulleys. Two LSRD cylinders were engaged on each shaft and two lever arms were used to control the transmission device. A rotation of 90 degrees was achieved using LSRD cylinders with 1.5-inch stroke length. Friction, stiffness, tracking, impulse response, and step response tests were performed at 70, 170, and 275 kPa (10, 25, and 40 psi) preload pressures to evaluate the transmission device and LSRD cylinder dynamic performance. The results demonstrated that at least 275 kPa preload pressure is needed to have a satisfactory performance. The passive antagonist hydraulic transmission can be used in applications such as wearable robots and telepresence devices.
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Abanum, Andrew Monday, Ibidabo David Alebere, and Chinemerem Patricks-E. "Determinants of IOGP Life-Saving Rules Compliance Among Nigerian Petroleum Industry Workers." In SPE Nigeria Annual International Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/208227-ms.

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Abstract Life-saving rules (LSRs) are a set of defined rules that support and complement general site-specific safety rules and procedures (SRPs). LSRs are popular in the oil & gas (O&G) industry and are part of the safety management system framework designed to prevent incidents in the workplace. Complying with LSRs ensures its intent of incident prevention, drives the goal of creating decent work, economic growth and sustainable development. With the continuum of incidents in the industry, total compliance with LSRs and SRPs still remains a mirage. Even though the introduction of LSRs in the O&G caused a paradigm shift from fair to better safety performance, incident investigations continue to unveil cases of violations/non-compliance. In the space of continuous improvement, it becomes expedient to determine possible causes of these LSRs and SRPs non-compliance, with a view to nipping the causal factors in the bud. A descriptive cross-sectional study was conducted to determine the factors affecting the level of workers compliance with IOGP LSRs in selected O&G companies operating in Delta State, Nigeria. The research recruited 317 sharp end workers and selected leaders, through a multistage sampling technique. A semi-structured, self-administered questionnaire was used as instrument for data collection. The study in its findings was able to elicit numerous compliance determinants arising from socio-demography, occupational and organisational factors. These factors are barriers to strengthen if the goal of total compliance and zero incident must be achieved in the workplace. The study recommends that management should comply with Thomas Legge's aphorisms 1 & 4 on SRPs and design training programmes for employees to be imparted with requisite knowledge needed for compliance, commit to safety and lead a positive safety culture to drive continuous improvement. Furthermore, there is the need to pursue total compliance with LSRs, SRPs and any site-specific safety rules to achieve zero incidents in the O&G industry.
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Griffin, Lisa W., and Kelly A. Belford. "Prediction of the Aerodynamic and Thermal Environment in Turbines." In ASME 1990 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1990. http://dx.doi.org/10.1115/90-gt-227.

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A numerical study of the steady, viscous flow prediction capabilities of the three-dimensional turbine stage code R0T0R3 is presented. Computations were performed with RAI3DC, a cascade version of R0T0R3 capable of being run in a planar or annular mode. Computed results are compared with experimental data obtained for Hodson’s cascade, Kopper’s cascade, and United Technologies Research Center’s Large Scale Rotating Rig (LSRR) first-stage stator. The code’s predictive capability is assessed in terms of the accuracy of predicted airfoil loadings, performance (including secondary flows in the LSRR case), boundary layers, and heat transfer. A grid refinement study was conducted in the LSRR case in an effort to more accurately model the boundary layers on the airfoil and endwall surfaces. The effects of the inlet total pressure profile in secondary flow prediction were also assessed.
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Zhu, Mingmin, Xiaoqing Qiang, Zhenzhou Ju, Yuchen Ma, and Jinfang Teng. "Experimental and Numerical Researches in a Four-Stage Low Speed Research Compressor Facility." In ASME Turbo Expo 2020: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/gt2020-16239.

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Abstract The flow fields in rear stages of multi-stage axial compressor is difficult to measure in detail owing to the limited height and space. Thus, low speed research compressor (LSRC) facilities which are modelled from rear stages have been widely used to explore the internal flow fields and improve compressor design. A newly-designed vertical LSRC facility is established and put into used in Shanghai Jiao Tong University. The construction and design features of this LSRC facility are introduced in this paper. A cantilevered stage has been tested in this test rig. Compressor performance, inter-stage parameters distributions and contours are measured at design point and near stall point. Steady single passage simulations for four-stage compressor are carried out to validate numerical methods and further interpret the internal flow fields in test stages. This vertical LSRC facility consists of inlet guide vane (IGV) and four repeated stages with an external diameter of 1.5 meter and a rotating speed of 900 RPM. The third stage is the mainly tested one, while the first and second stages provide the inlet conditions and the fourth stage provides the outlet conditions. Complete measuring methods and systems are established for this newly-built LRSC facility. The measurements of overall performance and inter-stage flow fields are carried out for test stage with cantilevered stator rows. The simulation for four-stage compressor are also performed for cantilevered configuration. The results of steady single-passage simulation have a similar trend with experimental ones, in terms of overall performance and parameters distributions.
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Kinoshita, Y., J. Kitajima, M. Shiraha, and A. Tatara. "Combustion Study on Methane-Fuel Laboratory Scaled Ram Combustor." In ASME 1992 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1992. http://dx.doi.org/10.1115/92-gt-413.

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Fundamental flameholding and combustion tests using simple V-gutters for the flame holders were investigated in order to obtain basic design data of a natural gas fueled ram combustor. Then Laboratory Scaled Ram Combustor (LSRC) was designed and fabricated in the first phase of the HYPR project using the fundamental flameholding and combustion tests results. Various tests were conducted to study combustion performance, such as flame stabilization, combustion efficiency, pressure loss and so on, of the LSRC at the simulated conditions of flight Mach number 3. The results indicate that high combustion efficiency is attainable with controlling the concentration of methane air mixture flowed into a flame holder even at a low equivalence ratio.

Reports on the topic "Lsr2":

1

Widjaja, I., and A. Elwalid. Performance Issues in VC-Merge Capable ATM LSRs. RFC Editor, September 1999. http://dx.doi.org/10.17487/rfc2682.

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Srinivasan, C., A. Viswanathan, and T. Nadeau. Multiprotocol Label Switching (MPLS) Label Switching Router (LSR) Management Information Base (MIB). RFC Editor, June 2004. http://dx.doi.org/10.17487/rfc3813.

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Nadeau, T., and A. Farrel, eds. Generalized Multiprotocol Label Switching (GMPLS) Label Switching Router (LSR) Management Information Base. RFC Editor, February 2007. http://dx.doi.org/10.17487/rfc4803.

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Yasukawa, S., S. Previdi, P. Psenak, and P. Mabbey. Routing Extensions for Discovery of Multiprotocol (MPLS) Label Switch Router (LSR) Traffic Engineering (TE) Mesh Membership. RFC Editor, July 2007. http://dx.doi.org/10.17487/rfc4972.

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To the bibliography