Dissertations / Theses on the topic 'LRHS'
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Borba, Maira de Souza. "Descartes e o ceticismo: o estatuto da dúvida na filosofia cartesiana." Universidade Federal de Minas Gerais, 2011. http://hdl.handle.net/1843/LRMS-8SNH8N.
Full textO objetivo dessa dissertação é analisar o estatuto da dúvida em Descartes, tendo em vista elucidar as raízes de sua constituição e determinar o papel do ceticismo nesse processo. Por meio da comparação com os céticos chega-se a conclusão de que Descartes foi influenciado principalmente pelos modernos contemporâneos a ele (Montaigne, Charron e La Mothe Le Vayer) e que, em relação ao ceticismo antigo, o mais importante é a distinção entre acadêmicos e pirrônicos, que será fundamental para a compreensão do filósofo. A análise da tese de Popkin, que se coloca como central, tendo em vista o objetivo de determinar o papel do ceticismo na filosofia cartesiana, revela que não há provas suficientes para validar a ideia de que a refutação do ceticismo seria o principal objetivo de Descartes. Todavia, o lugar do ceticismo na filosofia cartesiana não pode ser menosprezado, pois a dúvida deve ser vista como um passo necessário na busca da verdade. Há que se destacar o fato de que o ceticismo deve ser visto como exercendo uma influência tanto negativa, quanto positiva em Descartes. É por deixar de lado um, ou outro, desses aspectos que a maioria dos comentadores do filósofo apresenta teorias radicais ou insuficientes a respeito da relação entre Descartes e o ceticismo. Para se escapar a isso se deve atentar para a distinção entre ceticismo acadêmico e pirrônico, pois enquanto o ceticismo pirrônico é recusado por Descartes, muitos dos elementos do ceticismo acadêmico são assimilados por ele.
Kurth, Naëmi Langenegger Corinne. "LRS-Prävention in Literatur und Praxis /." Zürich : Hochschule für Heilpädagogik, 2009. http://www.bscw-hfh.ch/pub/bscw.cgi/d4332387/Masterarbeit.pdf.
Full textAl-Mufaraji, Moosa N. "Libraries and the development of information-handling in the educational system of Oman." Thesis, Loughborough University, 2000. https://dspace.lboro.ac.uk/2134/36044.
Full textCojanu, Alexandru Ioan. "Intrinsic Features of the Multisensory Cortical Area LRSS in the Ferret." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/159.
Full textHagood, Elizabeth. "Multisensory Input to the Lateral Rostral Suprasylvian Sulcus (LRSS) in Ferret." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1743.
Full textSchröter, Carolin. "AVWS »meets« LRS : Erfahrungen aus der therapeutischen Praxis." Universität Potsdam, 2013. http://opus.kobv.de/ubp/volltexte/2013/6852/.
Full textRüdell, Edith. "Lesen: 5 - Rechtschreiben: 6 schulische Fördermöglichkeiten bei LRS." Saarbrücken VDM Verlag Dr. Müller, 2006. http://d-nb.info/989178870/04.
Full textBaltzer, Charlotte. "LR:s inställning till kommunaliseringsreformen : En idé- och ideologianalys av "Skolvärlden" 1980-2010." Thesis, Uppsala universitet, Institutionen för pedagogik, didaktik och utbildningsstudier, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156762.
Full textBytautas, Kęstutis. "LRS Seimo narių grupavimas pagal balsavimą ir balsavimo kitimo aptikimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120620_112756-41462.
Full textPoliticians declare their behavior in different ways, so the only way to control it - monitoring. In this thesis tools for Lithuanian Parliament Members voting behavior are analyzed. The question is following: can Information technologies tool help to determine how membership in a faction or the position (opposition) is related with voting behavior? The main objectives of this work are Lithuanian Parliament members grouping by their voting behavior and its' change detection. In the thesis the 2008-2012 of the Parliament activities are analysed using statistical voting analysis. We use clustering for grouping members of the Parliament. A loose definition of clustering could be the process of organizing objects into groups whose members are similar in some way. A cluster (group) is a collection of objects which are similar between them and are dissimilar to the objects belonging to other clusters. We overviewed different clustering methods and their principles of operation, described the distance between the objects of calculation methods, quality evaluation criteria in this work. Voting data is stored in MySQL database, hence a tool was created for data processing. We describe all the stages of the work: the use of tools, coding of the votes, division of the votes into the periods. The following techniques were chosen: K-Means, Hierarchical Clustering with Complete (furthest neighbor), Average, Single (nearest neighbor) linkage. We use Euclidean and Manhattan methods for... [to full text]
Lehnen, Daniela. "LrhA als Regulator der Flagellen, Motilität, Chemotaxis und Typ-1-Fimbrien in Escherichia coli." [S.l.] : [s.n.], 2002. http://ArchiMeD.uni-mainz.de/pub/2002/0162/diss.pdf.
Full textBrookes, Paul Andrew. "Synthetic studies towards novel inhibitors of Ape1/Ref1 and LRH-1." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39141.
Full textSchwaderer, Juliane [Verfasser]. "LRH-1/NR5a2 in regulation of the immune system / Juliane Schwaderer." Konstanz : Bibliothek der Universität Konstanz, 2017. http://d-nb.info/1140736418/34.
Full textKramer, Holly. "The role of liver receptor homologue-1 (LRH-1) in colorectal cancer." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/50192.
Full textLai, Chun Fui. "The role of liver receptor homologue-1 (LRH-1) in breast cancer." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/30730.
Full textKyle, Fiona. "LRH-1 as a target for the development of new breast cancer therapies." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/55285.
Full textThiruchelvam, Paul. "LRH-1 as a key regulator of estrogen responses in breast cancer cells." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/10685.
Full textZhao, Jing. "Protein Kinases can differentially regulate transactivation activities of hLRH-1 through the modulation of cofactors interactions." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1271686070.
Full textMueller, Melanie. "Towards the development of modulators of LRH-1 as potential anti-cancer therapeutic leads." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/29112.
Full textSemrén, Philip. "On the Interaction Between Electromagnetic, Gravitational, and Plasma Related Perturbations on LRS Class II Spacetimes." Thesis, Umeå universitet, Institutionen för fysik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-184078.
Full textSeitz, Carina [Verfasser]. "Role of the nuclear receptor LRH-1 in T cell development and function / Carina Seitz." Konstanz : KOPS Universität Konstanz, 2018. http://d-nb.info/1209055694/34.
Full textFrança, Mônica Malheiros. "O papel do fator de transcrição POD-1 na regulação de SF-1 e LRH-1 em células tumorais da suprarrenal humana." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-03062014-162141/.
Full textSF-1 and LRH-1 have played a critical role in steroid production, adrenal and gonads. Moreover, there are evidences that they have acted in tumorigenesis process in these organs. POD-1 is downregulated in adrenocortical carcinoma (ACC) it seems to regulate Sf-1. In this work, it has been to analyse the role of POD-1 in SF-1 and LRH-1 regulation in adrenocortical tumor cells. The POD-1 overexpression has reduced SF-1/SF-1 expression. However, there was an increase of LRH-1 gene expression due to SHP expression decrease which is negative regulate of LRH-1. The POD-1 and SF-1 gene expression in transfected cells with siRNA-POD-1 has shown POD-1 decrease and SF-1 increase emphasizing a regulatory mechanism between POD-1 and SF-1. By ChIP assay it was shown that POD-1 binded in SF-1 promoter E-box sequence. It was not characterized that POD-1 binded in LRH-1 promoter, although POD-1 can bind in SHP promoter E-box sequence. The reduction of SF-1 expression by POD-1 has decreased the StAR expression, however, it was not enough to change tumor cell proliferation. In summary, POD-1 must have a wider role as regulator of fator transcription which controls tumorigenese process being a possible candidate as tumor supressor gene in adrenocortical cells.
Costa, Mariana Amalia Figueiredo. "Proteção induzida pela imunização de camundongos BALB/c com proteínas ribossomais de Leishmania (LRPs) contra a infecção com L. chagasi." Universidade Federal de Minas Gerais, 2010. http://hdl.handle.net/1843/UCSD-8H7K4N.
Full textA leishmaniose visceral é uma doença causada por protozoários intracelulares obrigatórios do gênero Leishmania (Ross, 1903), que são encontrados em países do Velho Mundo e nas Américas. É uma doença grave e que pode levar à morte, se não tratada. A aquisição de imunidade após a cura da infecção causada por L. major culmina na proteção contra a re-infecção pelo parasito, indicando a possibilidade do desenvolvimento de uma vacina contra a doença. Neste trabalho, a imunização com proteínas ribossomais de Leishmania (LRPs), isoladas da espécie L. infantum, associadas ao adjuvante saponina, foi capaz de induzir uma resposta imune celular do tipo Th1, observada pela produção elevada de IFN-, IL-12p70, GM-CSF e de anticorpos do isotipo IgG2a, específicos às LRPs. Observou-se que essa resposta imune foi capaz de induzir proteção nos animais contra a infecção com L. chagasi, verificada pela redução significativa da carga parasitária no baço e fígado dos animais imunizados, quando comparados aos grupos controle (salina e saponina). A proteção foi relacionada com a produção elevada de IFN-, IL-12p70 e GM-CSF e à baixa produção de IL-4 e IL-10, sendo a produção de IFN- dependente de IL-12 e proveniente principalmente de linfócitos T CD4+ , CD8+ e células natural killer. Portanto, as LRPs, como proteínas altamente conservadas entre as diferentes espécies de Leishmania sp., podem se constituir em candidatas para compor uma vacina pan-Leishmania.
Semrén, Philip. "Dissipative Perturbations on LRS Class II Cosmologies Using the 1+1+2 Covariant Split of Spacetime." Thesis, Umeå universitet, Institutionen för fysik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176037.
Full textBarnouin, Romain. "Étude des fonctions du récepteur nucléaire Liver Receptor Homolog-1 (Lrh-1) dans le système nerveux central." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. https://publication-theses.unistra.fr/restreint/theses_doctorat/2007/BARNOUIN_Romain_2007.pdf.
Full textLiver receptor homolog-1 (Lrh-1, Nr5a2) belongs to the family of the nuclear receptors. The objective of this PhD was to understand the functions of Lrh-1 in the various areas of the murine nervous system where it is expressed. Lrh-1 is detected in the ventral spinal cord and the dorsal root ganglia (DRG) during the development. In the adult mouse, Lrh-1 is expressed in several areas of the brain, in particular in the arcuate nucleus of the hypothalamus. Fonctions of Lrh-1 in the development of the neural network of the ventral spinal cord and the DRG. Lrh-1 is expressed in a sub-population of interneurons of the ventral spinal cord and DRG. These neurons belong to the locomotor and proprioceptive network. The absence of Lrh-1 leads to defects of proprioception by the reduction of related fibers of the DRG towards the ventral spinal cord. Moreover, the expression of several proteins of axonal guidance is modified in the mutant mice and could contribute to the phenotype. Functions of Lrh-1 in the arcuate nucleus of the hypothalamus: Lrh-1 is expressed in a sub-population of neurons expressing the neuropeptides Pomc and Agrp. The deletion of Lrh-1 in the neurons leads to the modification of the transcriptional profile of the hypothalamus, in particular the genes involved in energy and stress homeostasis. These alterations in genes expression are associated with impaired leptin production and glucocorticoids homeostasis, indicating that, in mice that lack Lrh-1 specifically in the CNS, several adaptive mechanisms to maintain homeostasis are severely disrupted
Barnouin, Romain Auwerx Johan. "Étude des fonctions du récepteur nucléaire Liver Receptor Homolog-1 (Lrh-1) dans le système nerveux central." Strasbourg : Université de Strasbourg, 2009. http://eprints-scd-ulp.u-strasbg.fr:8080/00001140.
Full textMagnier, Benjamin. "Rôle du récepteur nucléaire Liver Receptor Homolog-1 (LRH-1) dans l’homéostasie du cholestérol et des acides biliaires." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. https://publication-theses.unistra.fr/restreint/theses_doctorat/2007/MAGNIER_Benjamin_2007.pdf.
Full textThe goal of this work was to evaluate the in vivo role of the nuclear receptor Liver receptor homolog 1 (LRH-1) in the control of cholesterol and bile acid homeostasis. To this end, a mouse model in which the LRH-1 gene is specifically deleted in the hepatocytes was generated. These mice show a massive reduction of CYP8B1 and fail to produce cholic acid. In addition, we also show that the profound remodeling of the BA composition reduces significantly the efficacy of intestinal absorption of lipids and re-uptake of BAs and facilitates the removal of lipids from the body. Our studies hence unequivocally demonstrate a pivotal role for LRH-1 in determining the composition of BAs, which, in turn, has major consequences on the whole body lipid homeostasis. The second step of this work was to study the impact of the absence of LRH-1 on the hepatic transcriptome. The preliminary outcome of this study is suggestive for a predominant role of LRH-1 in both lipid metabolism and immune defense
Magnier, Benjamin Auwerx Johan. "Rôle du récepteur nucléaire Liver Receptor Homolog-1 (LRH-1) dans l'homéostasie du cholestérol et des acides biliaires." Strasbourg : Université de Strasbourg, 2009. http://eprints-scd-ulp.u-strasbg.fr:8080/00001130.
Full textThèse soutenue sur un ensemble de travaux. Titre provenant de l'écran-titre. Bibliogr. 21 p.
Williams, Jolin Shan. "Dynamics of Discrete Irregular Cosmological Models." Thesis, Stockholms universitet, Fysikum, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-110841.
Full textDenna avhandling undersöker konfigurationer av 8-600 Schwarzschild-massor, som är slumpmässigt utplacerade inom celler som tessellerar en 3-sfär. Utöver det är även innehållet i varje cell en spegelbild av granncellen. Denna symmetri ger upphov till en lokalt rotationssymmetrisk (LRS) kurva där Einsteins fältekvationer som beskriver dynamiken längs med är exakt integrerbara. Resultatet är en oregelbunden modell som består av diskreta massor, men vars dynamik är enkel att beräkna. Vi ser att dessa lokala inhomogeniteter ger upphov till beteenden som avviker från den sfäriska partikel-fyllda FLRW-modellen. Till exempel uppstår konfigurationer som uppvisar acceleration längs med LRS-kurvan, trots att innehållet består endast av ordinära massor med vakuum utanför och ingen kosmologisk konstant.
Annicotte, Jean-Sébastien. "Etude de fonctions pancréatiques du récepteur nucléaire orphelin Liver Receptor Homolog-1 (LRH-1) et du facteur de transcription E2F1." Université Louis Pasteur (Strasbourg) (1971-2008), 2004. https://publication-theses.unistra.fr/public/theses_doctorat/2004/ANNICOTTE_Jean-Sebastien_2004.pdf.
Full textThe liver receptor homolog 1 (LRH-1) and the pancreatic-duodenal homeobox-1 (PDX-1) are coexpressed in the pancreas during mouse embryonic development. Analysis of the regulatory region of the human LRH-1 gene demonstrates the presence of three functional binding sites for PDX-1. Electromobility shift assays and chromatin immunoprecipitation analysis show that PDX-1 binds to the LRH-1 promoter, both in cultured cells in vitro and during pancreatic development in vivo. Retroviral expression of PDX-1 in pancreatic cells induces the transcription of LRH-1, whereas reduced PDX-1 levels by RNA interference attenuate its expression. Consistent with a direct regulation of LRH-1 expression by PDX-1, PDX-1-/- mice expressed lower amounts of LRH-1 mRNA in the embryonic pancreas. Taken together, our data indicate that PDX-1 controls LRH-1 expression and identify LRH-1 as a novel downstream target in the PDX-1 regulatory cascade governing pancreatic development, differentiation and function. We evaluated the effects of E2F1 on glucose homeostasis using E2F1-/- mice. E2F1-/- mice show an overall reduction in pancreatic size, as the result of impaired postnatal pancreatic growth. These animals furthermore have dysfunctional b-cells, linked to impaired PDX-1 activity. Because of the disproportionate small pancreas and dysfunctional islets, E2F1-/- mice secrete insufficient amounts of insulin in response to a glucose load, resulting in glucose intolerance. Despite this glucose intolerance, E2F1-/- mice do not develop overt diabetes mellitus because they are insulin hypersensitive, secondary to a diminished adipose tissue mass and altered adipocytokine levels, which compensates for the defect in insulin secretion. These data demonstrate that factors controlling cell proliferation, such as E2F1, determine pancreatic growth and function, subsequently affecting metabolic homeostasis
Weißmann, Katja [Verfasser], Bernhard [Akademischer Betreuer] Blanz, Marcus [Akademischer Betreuer] Wilke, and Christian [Akademischer Betreuer] Gaser. "Hirnmorphologische Unterschiede zwischen Kindern, Jugendlichen, Erwachsenen mit Lese-Rechtschreibstörung (LRS) und Kontrollprobanden / Katja Weißmann. Gutachter: Bernhard Blanz ; Marcus Wilke ; Christian Gaser." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2013. http://d-nb.info/1036873137/34.
Full textVan, Ghelder Cyril. "Le locus de résistance Ma des Prunus vis-à-vis des nématodes à galles : Originalité structurale et évolution dans la famille des NBS-LRRs chez les plantes." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://www.theses.fr/2019AZUR6006.
Full textRoot-knot nematodes (RKNs), Meloidogyne spp., are extremely polyphagous pests that severely challenge plants worldwide and especially perennials. The specific genetic resistance of plants mainly relies on NBS-LRR receptor genes (or NLRs grouping TNL, CNL and RNL subfamilies) that are pivotal factors for control of pests and pathogens. In Prunus spp., the Ma plum TNL gene confers resistance to all RKNs tested, whereas the RMja almond gene displays a more restricted spectrum of resistance (R). Moreover, the Ma predicted protein shows a peculiar TNL structure due to a C-terminal region made of five repeated domains, designated post-LRR domains (PLs). In this context, this thesis work has characterised the originality and the distribution of this uncommon structure among diverse plant proteomes and has revealed the genetic relationship between the Ma and RMja genes.We first studied the frequency, distribution and structural characteristics of TNL genes and PL domains within the peach genome, the reference genome for Rosaceae. The finding of PL domains, which have been identified in two thirds of the 195 TNLs, allowed us to define specific motifs that improve the detection of this poorly known domain in Angiosperms. We found that the PL domain is specific of TNLs and is present in Angiosperm genomes in a proportion similar to the one established for peach. Besides, TNLs displaying multiple PL domains are rare in plants. The five-PL domain pattern is probably unique to Ma and its orthologues and was probably inherited from their common ancestor in the order Rosales. We then investigated the NBS-LRR repertoire of the conifers (Gymnosperms), an ancient taxonomic group, for which the data related to this gene family are unclear. By analysing seven reference transcriptomes, we highlighted a large and diverse NBS-LRR arsenal in conifers but, surprisingly, no PL signatures have been detected. The examination of ancient plant proteomes revealed that only Ginkgo biloba displayed a few PL signatures. Our results suggest that a partial acquisition of the PL domain occurred early in seed plants and was followed by an adaptive expansion in Angiosperms. Additionally, we showed that conifers and Rosaceae have numerous RNLs and TNLs. By enlarging our study to other land plant genomes, we uncovered an average ratio of 1:10 between RNLs and TNLs numbers.We finally carried out a high-resolution mapping of the RMja gene in almond. Using a BAC library, RMja was localised into the Ma resistance cluster and the Ma orthologue is by far the best candidate. The sequence comparison between three orthologous regions of the Ma locus, i.e. plum (complete R spectrum), almond (incomplete R spectrum) and peach (null R spectrum) highlighted a unique conserved structure of the Ma orthologues. Our results suggest that the polymorphism contained in the PL-domain repeats might underlie differential resistance interactions with RKNs and an original immune mechanism in woody perennials. In these immune processes for recognition or signalling, other components such as RNLs might be involved. This work paves the way for future comparative and functional approaches aiming to unravel the molecular determinants involved in the resistance to RKNs
Ничипорчук, Артем Олексійович. "Дослідження стандартів сумісності систем e-learning з метою створення системи дистанційного навчання ВНЗ." ЗДІА, 2016. http://dspace.zsea.edu.ua:8080/jspui/handle/12345/5.
Full textRepass, Lawrence M. "Optimal stationing of radar pickets and anti-ballistic missile defenders for long range surveillance and tracking (LRS & T) and ballistic missile defense (BMD) operations." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2006. http://library.nps.navy.mil/uhtbin/hyperion/06Sep%5FRepass.pdf.
Full textThesis Advisor(s): Gerald Brown. "September 2006." Includes bibliographical references (p. 51-52). Also available in print.
Bott, Christof. "Welches Trainingsverfahren ist zur Therapie von Kindern mit LRS am effektivsten? Auswirkungen auf die Lese- und Rechtschreibleistung und die funktionale Organisation von Sprache im Gehirn /." [S.l. : s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975678280.
Full textHoffman, Bradley R. "Evaluation of the Automated Laser Rut Measurement System Used by the Ohio Department of Transportation." Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1321627068.
Full textFreudenberger, Martin [Verfasser]. "Analytische Untersuchungen plutoniumhaltiger Loesungen mittels Laser-Raman-Spektroskopie (LRS) unter besonderer Beruecksichtigung der Reaktionen Pu(IV)-Ru(III)-HNO₃ und Pu(VI)-H₂O₂ / Martin Freudenberger." Karlsruhe : KIT-Bibliothek, 2018. http://d-nb.info/1197076743/34.
Full textLefèvre, Lise. "Rôle de la polarisation M2 des macrophages dans le contrôle d'infections fongiques et parasitaires : implication des récepteurs nucléaires PPARgamma et LRH-1 et des récepteurs lectine de type C." Toulouse 3, 2013. http://www.theses.fr/2013TOU30088.
Full textMacrophages are key cells of the innate immune response and have phenotypic and functional plasticity which allows them to adapt to their microenvironment. Among these signals, the inflammatory and metabolic states, as well as the pathogenic agents, will influence the macrophage polarization. In this work, we focused on two environmental factors (i) the type 2 diabetes, characterized by a low grade inflammation and an increased susceptibility to fungal infections (ii) a parasitic infection, the visceral leishmaniasis. We have shown that a high fat diet induced-insulin resistance promoted an inflammatory M2b polarization of macrophages associated with an increased susceptibility to gastrointestinal candidiasis. We then demonstrated that ligands of the nuclear receptor PPARgamma shift the M2b polarization toward M2a phenotype, effective to eliminate Candida albicans. This macrophage polarization is characterized by the overexpression of Dectin-1 and Mannose (MR), two membrane macrophage C-type lectin receptors involved in the yeast internalization and in the production of reactive oxygen intermediates (ROS). This work is published in PLoS One, 2010, September 20, 5 (9): e12828. Doi: 10. 1371/journal. Pone. 0012828. Thus, the study of the signaling pathways leading to PPAR? activation could be of therapeutic interest during fungal infections. Therefore, we focused on the LRH-1 nuclear receptor, known to regulate the expression of enzymes involved in the synthesis of potential PPARgamma ligands. Here, we demonstrated for the first time the involvement of LRH-1 in the M2 macrophage polarization. Indeed, LRH-1 is implicated in the production of PPARgamma endogenous ligands and hence in its activation. We also showed that mice deficient for LRH-1 specifically in macrophages exhibit increased susceptibility to Candida albicans infection, associated with altered M2 polarization related-candidacidal functions. These results suggest that LRH-1 could be a novel therapeutic target in the treatment of fungal infections, promoting M2 polarization favorable for the host. This work is currently under submission. In the second part of this work, we studied the influence of visceral leishmaniasis on the macrophage polarization. Interestingly, we report that the macrophage response in vivo against Leishmania infantum is characterized by a M2b-like phenotype displaying a C-type lectin receptors signature composed of Dectin-1, MR and the DC-SIGN homologue SIGNR3. We also demonstrated that these receptors influenced the outcome of L. Infantum infection. Indeed, Dectin-1 and MR are involved in the L. Infantum internalization by macrophages and in the production of ROS, inflammatory bioactive lipids, and cytokines such as leukotriene B4 (LTB4) and interleukin 1beta, which enable parasite elimination. By contrast, SIGNR3/DC-SIGN favors parasite resilience through inhibition of the microbicidal functions of macrophages. Confirmation of these results in primary human macrophages highlights the divergent role for these C-type lectin receptors to the pathogenesis of Leishmania infantum. This work demonstrates the importance of lectins/LTB4/LXA4 axis in the control of the inflammatory mediator's production responsible for parasite elimination. Our findings suggest that effective modulation of these cellular and molecular factors might shift the Leishmania-macrophage interaction for the benefit of the patient. This work is published in Immunity, 2013, May 23;38(5):1038-49. Doi: 10. 1016/j. Immuni. 2013. 04. 010
Venteclef, Nicolas. "Etude du rôle << Liver Receptor Homolog-1 >> dans la régulation de la réponse inflammatoire hépatique et dans l'homéostasie du cholestérol." Paris 6, 2007. http://www.theses.fr/2007PA066268.
Full textGuitarra, Silvana Raquel. "Modélisation multi-échelles des mémoires de type résistives (ReRAM)." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0537/document.
Full textA model for the switching of resistive random-access memories (ReRAM) is presented. This model is based on two hypotheses: (1) the resistive switching is caused by changes that occur in the narrow zone (active region) of the conductive filament under the influence of the electric field and (2) the resistive switching is a stochastic process governed by a switching probability. The active region is represented by a net of vertical connections, each one composed of three electrical elements: two of them are always low resistive (LR) while the third one acts as a breaker and can be low or high resistive (HR). In the model, the change of the breaker's state is governed by a switching probability (P$_{s}$) that is compared with a random number $p$. P$_{s}$ depend on the voltage drop along the breaker and the threshold voltage, V$_{set}$ or V$_{reset}$ for set (HR to LR) or reset (LR to HR) processes. Two conduction mechanism has been proposed: ohmic for the low resistive state and trap-assisted tunneling (TAT) for the high resistive state. The model has been implemented in Python and works with an external C-library that optimizes calculations and processing time. The simulation results have been successfully validated by comparing measured and modeled IV curves of HfO$_{2}$-based ReRAM devices of nine different areas. It is important to note that the flexibility and easy implementation of this resistive switching model allow it to be a powerful tool for the design and study of ReRAM memories
Jacquemin, Godefroy. "Implication des monocytes-macrophages dans le développement de l'inflammation colique et de la carcinose péritonéale d'origine colorectale : rôle des récepteurs lectine de type-c et des récepteurs nucléaires PPARy et LRH-1." Thesis, Toulouse 3, 2021. http://www.theses.fr/2021TOU30277.
Full textInvolvement of monocytes/macrophages in the development of colonic inflammation and peritoneal carcinomatosis of colorectal origin: Role of C-type lectin receptors and nuclear receptors PPARγ and LRH-1.Monocytes and macrophages, key cells of innate immunity, express a large panel of membrane and nuclear receptors allowing them to modulate their phenotypes and functions in response to environmental stimuli. Due to this cellular adaptability, monocytes/macrophages control the innate and adaptive immune responses. Thus, these cells play a central role in the development of many pathologies, and consequently, represent relevant therapeutic targets. In this work, we first focused on the role of macrophage C-type lectin receptors in the control of colonic inflammation. We show, using two mouse models specifically invalidated for Dectin-1 and mannose receptor (MR) in the myeloid lineage, that Dectin-1 participates in the development of intestinal inflammation, whereas MR prevents it. Indeed, in a DSS (Dextran Sodium Sulfate)-induced colitis model, the Dectin-1 receptor on macrophages induces an increase in the recruitment of inflammatory monocytes in the colon in a CCL2-dependent manner. We also demonstrate that Dectin-1 is involved in the polarization of colonic macrophages towards a pro-inflammatory phenotype. Indeed, Dectin-1 promotes the synthesis of leukotriene B4 (LTB4) which, in turn, induces the secretion of interleukin-1β (IL-1β). These results highlight the involvement of the Dectin-1/CCL2/LTB4/IL-1β axis in the development of colonic inflammation and conversely assign a protective role to MR in this context. These data were correlated with an increase in Dectin-1 expression and a decrease in MR expression in the colon of inflammatory bowel disease (IBD) patients. This work is published in Cell Reports 2020: Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response. Cell Rep. 30, 4386-4398.e5In a second step, we investigated the roles of the nuclear receptors PPARγ (peroxisome proliferator-activated receptor) and LRH-1 (Liver receptor homolog-1) of macrophages in the development of peritoneal carcinomatosis of colorectal origin (PCR). We have demonstrated for the first time, using two mouse models deleted for LRH-1 or PPARγ specifically in the myeloid lineage, that these nuclear receptors play a major role in the differentiation of myeloid precursors into myeloid-derived suppressor cells (MDSC) during PCR. Indeed, the absence of LRH-1 and PPARγ in myeloid cells inhibits MDSC differentiation and promotes the reactivation of the anti-tumor immune system. Associated with this immune reactivation, the mice show a strong decrease in tumor burden, identifying LRH-1 and PPARγ as novel therapeutic targets capable of removing immunosuppression. Using an in vitro model of MDSC differentiation, we demonstrated the interdependence of LRH-1 and PPARγ in MDSC differentiation via the activation of the LRH-1/15-HETE/PPARγ axis. In parallel, we demonstrated the ability of an LRH-1 inverse agonist (ML-180) to inhibit PCR development, MDSC differentiation and colon tumor cell proliferation. This work identifies the nuclear receptor LRH-1 as a key element in PCR progression and opens new therapeutic perspectives allowing both to remove immunosuppression by blocking MDSC differentiation and to directly inhibit colon tumor cell proliferation. This work is in progress
Wu, Marcio Jolhben. "Análise do efeito do investimento inicial no dilema do prisioneiro contínuo iterado simultâneo e alternado na presença e ausência de ruído em diferentes cenários de incerteza: contrapondo as estratégias RTS e LRS por meio da simulação bas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/47/47132/tde-02032016-153429/.
Full textThe prisoner\'s dilemma is generally seen as the starting point for understanding the problem of cooperation. In comparison with the discreet and iterated prisoner\'s dilemma, few studies exist on the continuous iterated prisoner\'s dilemma. Most of the works that have investigated the continuous iterated prisoner\'s dilemma has concentrated in the period from 1990 to 2000, not getting conclusive results on the best strategy to be adopted in this type of game. Two different strategies stand out in this kind of dilemma. The first is the RTS strategy (Raise-the-Stakes) of Roberts and Sherrat (1998) that tests the ground before increasing investment in the relationship. The second is the model deriva LRS (Linear Reactive Strategies) de Wahl and Nowak (1999a). This last strategy being in Nash equilibrium cooperative presents three characteristics: (i) generosity, i.e., investing as much as possible at the beginning of the cooperation relationship; (ii) optimism, i.e., rely on the best scenario for the next rounds, and (iii) intransigence. This research has as main goal to reconcile opposing RTS strategies and LRS in a continuous iterated prisoner\'s dilemma, in the presence and absence of noise, with simultaneous moves and alternate and for different values of the parameter w (probability of interacting again). We restrict our analysis to a set of six strategies: ALLC, ALLD, TFT, RTS, LRS and RTSM (halfway between RTS and LRS). The method used was the agent-based simulation (ABM) in tournament format, similar to that of Axelrod (2006), Roberts (1998), Sherratt & Nowak & Sigmund (1992) and Nowak & Sigmund (1993). We use the NetLogo software and document the whole process of design and construction of the tool model TRACE (TRAnsparent and Comprehensive model Evaludation). The results show that most strategies are more favoured unions when the game consists of alternating plays rather than simultaneous. The RTS strategy had better performance in simultaneous games for intermediate values of w, in the presence or absence of noise. In turn, the IRS strategy had better performance when simultaneous games, in the presence or absence of noise, or switched, and in the presence of noise, in both cases, for large values of w
Hofsten, Jonas von. "Developmental and reproductive regulation of NR5A genes in teleosts." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-374.
Full textSantos, Pablo Vieira dos. "Utiliza??o de m?todos n?o destrutivos na avalia??o da qualidade da madeira de Cariniana legalis (Mart.) Kuntze proveniente de plantios de restaura??o florestal." Universidade Federal Rural do Rio de Janeiro, 2016. https://tede.ufrrj.br/jspui/handle/jspui/1793.
Full textMade available in DSpace on 2017-06-20T15:28:09Z (GMT). No. of bitstreams: 1 2016 - Pablo Vieira dos Santos.pdf: 2713237 bytes, checksum: 034b9528933152d64f409aa5701ceba6 (MD5) Previous issue date: 2016-02-26
Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
Forest restoration is an important mechanism which can recover anthropized environments. In this context, the use of native species in order to wood production has become a very positive alternative in the economic viability of this activity, so that, know information about native species with potential for production of high quality wood, used in forest restoration, is an important task. Concerning this, the objective of this study was to evaluate the quality of the wood Cariniana legalis (Mart.) Kuntze from forest restoration plantings, through non-destructive methods. Were selected 20 individuals in the field through a silvicultural assessment and then were determined dendrometric characteristics: diameter at breast height (DBH), total height, tree standing volume and bark thickness. Four different non-destructive methods of assessing wood quality based on the DBH (1.30 m from the base of the tree): extensometry, resistograph, impulse tomograph and x-ray densitometry (pulling out wood samples by Pressler probe). The longitudinal residual strain (LRS) average of wood was 0.054 mm, a value lower than that found in the literature for many species, as for the Eucalyptus genus. The amplitudes generated by resistograph allowed the estimation the basic density values of wood Cariniana legalis, presenting a positive and significant correlation (r = 0.68) at 1% significance level. The average apparent density average, obtained by X-ray densitometry, was 0.528 g / cm3. In general, Cariniana legalis threes were homogeneous, with good sanity wood (without internal rot or hollow) and moderately dense density being easy workability and suitable for the furniture industry.
A restaura??o florestal ? um importante mecanismo, no qual se consegue recuperar ambientes antropizados. Neste contexto, o uso de esp?cies nativas visando a produ??o madeireira tem se tornado uma alternativa bastante positiva na viabiliza??o econ?mica desta atividade, de modo que, conhecer informa??es a respeito de esp?cies nativas com potencial na produ??o de madeira de alta qualidade, utilizadas na restaura??o florestal, ? uma tarefa de grande import?ncia. Nesse sentido, o objetivo deste trabalho foi avaliar a qualidade da madeira de Cariniana legalis (Mart.) Kuntze proveniente de plantios de restaura??o florestal, atrav?s de m?todos n?o destrutivos. Foram selecionados 20 indiv?duos no campo por meio de uma avalia??o silvicultural e em seguida determinou-se as caracter?sticas dendrom?tricas (di?metro ? altura do peito (DAP), altura total, volume da ?rvore em p? e a espessura da casca). Quatro diferentes m?todos n?o destrutivos de avalia??o da qualidade da madeira foram utilizados, sendo eles a extensometria, resistograf?a, tomografia de impulso e densitometria de raios X (retirando-se amostras do lenho por meio da sonda de Pressler), todos os ensaios tiveram como refer?ncia a altura do DAP (1,30m a partir da base da ?rvore). A deforma??o residual longitudinal (DRL) m?dia da madeira foi de 0,054 mm, valor este inferior ao encontrado na literatura para muitas esp?cies, como para o g?nero Eucalyptus. As amplitudes geradas pelo resist?grafo permitiram estimar os valores de densidade b?sica da madeira de Cariniana legalis, apresentando uma correla??o positiva e significativa (r = 0,68) ao n?vel de 1% de signific?ncia. A densidade aparente m?dia, obtida por meio da densitometria de raios X, foi de 0,528 g/cm3. De maneira geral os indiv?duos de Cariniana legalis se mostraram homog?neos, apresentando boa sanidade do lenho (sem ocos internos ou podrid?es) e densidade moderadamente densa, sendo de f?cil trabalhabilidade e indicada para a ind?stria moveleira
Křížová, Martina. "Indexování dat pohybujících se objektů." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2010. http://www.nusl.cz/ntk/nusl-237256.
Full textBischof, Dorothea. "Modellorientierte Therapie bei Störungen des Leseerwerbs." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21345.
Full textIn order to follow the lessons in school, children must be able to read with speed as well as with accuracy and a proven ability to comprehend texts. International school performance studies show that a high proportion of students already have inadequate reading skills in elementary school and therefore need additional support or therapy measures. Based on this observation, an evaluation of two different interventions among second- and third-graders is reported: A pre-post follow-up design with double pre-measurement, aiming at the increase of the students' reading skills. A model-guided therapy method for improving the reading speed of words and a parental training course for the improvement of reading accuracy and reading speed of pseudowords. 58 second- and third-graders with a serious reading backlog were selected to participate in the interventions and were assigned to either the therapy program or the parental training. Both groups received daily 45-minute training over a 5 week period. While the training of the therapy group was held by a therapist and took place at school, the training of the support group was carried out by parents at home. Changes in reading speed, reading comprehension and various eye movement parameters were evaluated.
Guitarra, Silvana Raquel. "Modélisation multi-échelles des mémoires de type résistives (ReRAM)." Electronic Thesis or Diss., Aix-Marseille, 2018. http://theses.univ-amu.fr.lama.univ-amu.fr/181210_GUITARRA_584ohbsor62rwx899lsxvt26qyx_TH.pdf.
Full textA model for the switching of resistive random-access memories (ReRAM) is presented. This model is based on two hypotheses: (1) the resistive switching is caused by changes that occur in the narrow zone (active region) of the conductive filament under the influence of the electric field and (2) the resistive switching is a stochastic process governed by a switching probability. The active region is represented by a net of vertical connections, each one composed of three electrical elements: two of them are always low resistive (LR) while the third one acts as a breaker and can be low or high resistive (HR). In the model, the change of the breaker's state is governed by a switching probability (Ps) that is compared with a random number p. Ps depend on the voltage drop along the breaker and the threshold voltage, V_{set} or V_{reset} for set (HR to LR) or reset (LR to HR) processes. Two conduction mechanism has been proposed: ohmic for the low resistive state and trap-assisted tunneling (TAT) for the high resistive state. The model has been implemented in Python and works with an external C-library that optimizes calculations and processing time. The simulation results have been successfully validated by comparing measured and modeled IV curves of HfO₂-based ReRAM devices of nine different areas. It is important to note that the flexibility and easy implementation of this resistive switching model allow it to be a powerful tool for the design and study of ReRAM memories
Pan, Chien-Ting, and 潘建廷. "Preparation of LRH-1 Antibody & Regulation of CYP11A1 Gene by LRH-1." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/20779153362660582943.
Full text國立臺灣大學
生理學研究所
93
CYP11A1 gene encodes P450scc enzyme, which controls the first and rate-limiting step of steroidogenesis by conversion of cholesterol to pregnenolone. CYP11A1 gene is expressed in many steroidogenic tissues like adrenal and gonad. Liver receptor homolog-1 (LRH-1) is a transcription factor and belongs to a member of nuclear receptor NR5A family. LRH-1 is expressed in some steroidogenic tissues such as ovary and may play a role in the regulation of steroidogenic gene. To study the function of LRH-1, two peptides of mouse LRH-1 were produced in E. coli for the generation of antibody. This antibody was used to detect the presence of LRH-1 in rat primary luteal cells by Western blotting. Transfection of LRH-1 expression vector in 293T cell line also can be detected by Western blotting. To examine the ability of LRH-1 in the regulation of CYP11A1 gene expression, we cotransfected LRH-1 expression vector and human CYP11A1 promoter construct into 293T cell line. LRH-1 can enhance the shortest 1.5 kb CYP11A1 promoter activity. Two functional SF-1 binding sites were located at -40 and -1600 in CYP11A1 promoter. By mutating the SF-1 binding sites, we found that SF-1 binding site located at -40 is the major site of LRH-1 binding to CYP11A1 promoter. Induction of CYP11A1 promoter activity by LRH-1 was inhibited by Dax-1. LRH-1 can be conjugated with post-translation modification protein SUMO-1 and we found that lysine 289 is the major conjugation site of SUMO-1. When LRH-1 was conjugated with SUMO-1 the ability of LRH-1 inducing CYP11A1 promoter activity was inhibited and that was independent of Dax-1 function. We found that LRH-1 may not be stable in the transfected cell.The proteasome inhibitor, MG-132, can increase the amount of LRH-1 protein in transfected cell.
Ferguson, Ronald Aubrey. "Units in integral cyclic group rings for order LRPS." Thesis, 1997. http://hdl.handle.net/2429/6770.
Full textWu, Mei-Ling, and 吳美伶. "Regulation of LRH-1 transcriptional activity." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/57874887924244892222.
Full text國立臺灣大學
生理學研究所
94
Liver receptor homolog-1 (LRH-1) is a member of nuclear receptor 5A subfamily. LRH-1 is expressed in steroidogenic tissues and has been shown to possess the ability to regulate the expression of steroidogenic genes. The aim of this study is to evaluate the regulation of mouse LRH-1 (mLRH-1) transcriptional activity. Our previous studies indicated that mLRH-1 stimulated the expression of human CYP11A1 promoter and N-terminal deletion of mLRH-1 enhanced the transcriptional activity of mLRH-1. In this study, two C-terminal deletions of mLRH-1 were constructed to examine the effect of C-terminus on mLRH-1. We found that mLRH-11-240 lacking of ligand binding domain almost lose transcriptional activity and had a dominant negative effect on mLRH-1 mediated transcription. The mLRH-11-191 with further deletion of hinge region and a part of DNA binding domain still located in the nucleus but had no dominant negative effect on mLRH-1-mediated transcription. LRH-1 can be conjugated with a post-translational modifier protein, small ubiquitin-related modifier-1 (SUMO-1). By mutating the potential SUMO-1 binding sites, we found that the lysine 289 of mLRH-1 is the major SUMO-1 conjugation site. In addition, the sumoylation at lysine 289 may inhibit mLRH-1 transcriptional activity. The members of PIAS family are recently known to be E3-like ligases that control the conjugation of SUMO-1 to target protein. Our cotransfection experiment showed that PIASxα, PIASxβ and PIASy can repress mLRH-1-induced transcription and PIASy had a most significant effect. And it’s suggested that PIASxαand PIASy-mediated repression of mLRH-1 is independent of mLRH-1 sumoylation. We further proved that mLRH-1 could interact with PIASy in vitro. In this study we found that: 1、The C-terminus of mLRH-1 is necessary for its transcriptional activity. Deletion of C-terminus increases the protein amount of mLRH-1. 2、SUMO-1 is mainly conjugated to lysine 289 of mLRH-1 that represses the transcriptional activity of mLRH-1. 3、SUMO E3 ligase PIASxα, PIASxβ and PIASy can repress mLRH-1-induced transcription. The repression of mLRH-1 transcriptional activity mediated by PIASxαand PIASy is independent of mLRH-1 sumoylation. 4、PIASy can directly interact with mLRH-1.
Richards, Gregory R. "The regulator LrhA and lipase activity in Xenorhabdus nematophila insect pathogenesis." 2008. http://www.library.wisc.edu/databases/connect/dissertations.html.
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