Dissertations / Theses on the topic 'LPV approach'
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Attallah, Aly [Verfasser]. "Distributed Control for Complex Mission Scenarios With Non-Holonomic Agents - An LPV Approach / Aly Attallah." München : Verlag Dr. Hut, 2021. http://d-nb.info/1238423078/34.
Buľák, Marián. "Trendy modernizace technologií pro řízení letů v okolí civilních letišť." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2019. http://www.nusl.cz/ntk/nusl-401509.
Attallah, Aly [Verfasser]. "Distributed control for complex mission scenarios with non-holonomic agents – an LPV approach / Aly Saeed Aly Aly Attallah." Hamburg : Universitätsbibliothek der Technischen Universität Hamburg-Harburg, 2021. http://nbn-resolving.de/urn:nbn:de:gbv:830-882.0135993.
Petersson, Daniel. "A Nonlinear Optimization Approach to H2-Optimal Modeling and Control." Doctoral thesis, Linköpings universitet, Reglerteknik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-93324.
Yamamoto, Kazusa. "Control of electromechanical systems, application on electric power steering systems." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAT069/document.
Nowadays, modern vehicles are equipped with more and more driving assistance systems, among them Electric Power Steering (EPS) helps the driver to turn the wheels. Indeed, EPS provides through an electric motor, an additional torque according to the driver's behaviour and the vehicle's dynamics to reduce the amount of effort required to the driver. Therefore, a torque control is developed based on the torque sensor signal which measures in practice the torsion bar torque (corresponding to an image of the driver torque). Consequently, this component is essential to the functioning of EPS systems.Indeed, a torque sensor failure usually leads to shut-off the assistance which may increase the risk of accident. Regarding functional safety, a back-up mode is recommended and required by more and more car manufacturers. On the other hand, a major challenge for automotive suppliers is to reduce cost production in order to meet growing markets demands and manage in the competitive sector. This issue considering a reduction of sensors' numbers and analysis of vehicle's dynamics is therefore an extension of applying the safety strategy. This thesis, carried out within JTEKT Europe, addresses these various issues.After introducing an overview of the different EPS systems, some models used for the design of controllers and estimators are presented. Then, two methods to estimate the driver torque subject to road disturbances and noise measurements are proposed: the first is a proportional integral observer (PI) with mixed synthesis $H_infty / H_2 $, whereas the second is an $ H_infty $ filtering approach. Then, several control strategies are proposed according to two different cases, either by using a PI observer which estimates the system states and the driver torque (LQR, LPV feedback control) or by not taking into account the driver torque estimation ($ H_infty $dynamic output feedback control). This latter approach has the advantage to require less measurements than the previous one. These approaches have been validated in simulation and implemented on a prototype vehicle where promising results have been obtained
Bouchama, Fawzia. "Synthèse d’observateurs continus-discrets pour les systèmes non linéaires : Application au Train Autonome." Electronic Thesis or Diss., Valenciennes, Université Polytechnique Hauts-de-France, 2024. http://www.theses.fr/2024UPHF0005.
This thesis contributes to the collaborative project "Train de Fret Autonome'' led by the SNCF and aims to control autonomous freight trains in order to guarantee reliable and safe autonomous driving in all environmental conditions. In this context, our contributions concern the development of estimators for accurately reconstructing the train position and longitudinal speed under variable wheel-rail adhesion conditions. The major difficulty arises from the fact that on-board odometric sensors provide a measurement of wheel rotation at axle level, but do not directly detect the phenomenon of wheel slippage, resulting in inaccurate estimation of the longitudinal speed of the train. To overcome this problem, it is necessary to make a precise recalibration using the position of the train measured by radio beacons installed on the rail. Nevertheless, this measurement is discrete with a variable sampling period. One of the challenges is to consider train measurements that combine both continuous and aperiodically sampled measurements. Thus, the main theoretical contribution of this thesis is the design of a continuous-discrete observer for a class of multi-input/multi-output systems with continuous noisy outputs and aperiodically sampled outputs. This observer is designed to meet the specifications of the "Autonomous Freight Train" project, in order to estimate train speed under variable adhesion conditions. The performance of this observer is shown in simulation and compared with other approaches to train speed estimation, then validated experimentally via an experimental test program carried out at the Centre d'Essai Ferroviaire of Tronville-en-Barrois
Hvězda, Michal. "Model systému automatického řízení přesného přiblížení a přistání civilního dopravního letadla za použití informací DGNSS." Doctoral thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-438882.
Do, Anh Lam. "Approche LPV pour la commande robuste de la dynamique des véhicules : amélioration conjointe du confort et de la sécurité." Thesis, Grenoble, 2011. http://www.theses.fr/2011GRENT114/document.
This work concerns the development of advanced control methods for automotive suspensions to improve road holding and passenger comfort, while satisfying the technological constraints related to the suspension actuators (passivity, nonlinearity, structural limit). In the first part, we propose two control schemes by polytopic LPV (Linear Parameter Varying) approach and by Strong Stabilization with genetic algorithm optimization to solve the comfort/handling and comfort/suspension travel conflits. In the second part, to solve the full semi-active suspension problem, we develop first a generic strategy for general LPV systems subject to actuator saturation and state constraints. The problem is studied in the form of resolution matrix of linear inequalities (LMI) that allows synthesizing an LPV controller and an anti-windup gain to ensure the stability and performance of the closed-loop system. Second, the theoretical result is applied to the case of semi-active suspension control. The proposed methods are validated by an evaluation based on an industrial standard and simulations on a nonlinear quarter vehicle model
Petersson, Daniel. "Nonlinear optimization approaches to H2-norm based LPV modelling and control." Licentiate thesis, Linköpings universitet, Reglerteknik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-59886.
Bouali, Anis. "Approche descripteur pour l’analyse et la commande des systèmes LPV rationnels." Nantes, 2008. http://www.theses.fr/2008NANT2119.
Linear parameter dependent models are useful to describe behavior of plants with dynamical characteristics evolving widely with operating conditions. Such models are more general then linear time invariant ones. Among the class of LPV systems those with a rational dependency on the varying parameter are of particular interest. It is shown in this work that such systems can always be recast into equivalent descriptor systems with an affine dependency on the parameters. Original methods for the analysis and the control of LPV descriptor systems have been proposed. In the case of affine descriptor systems, these methods rely on optimization problems having LMI characterizations. Such problems are known to be highly tractable. Based on these results and the properties of the strong equivalence, new conditions for the analysis and the control of rational LPV systems as well as a parameterization of all stabilizing controllers have been presented. Finally, some numerical examples are given in order to appreciate the interest and limitations of the proposed results
Do, Anh Lam. "Approche LPV pour la commande robuste de la dynamique des véhicules : amélioration conjointe du confort et de la sécurité." Electronic Thesis or Diss., Grenoble, 2011. http://www.theses.fr/2011GRENT114.
This work concerns the development of advanced control methods for automotive suspensions to improve road holding and passenger comfort, while satisfying the technological constraints related to the suspension actuators (passivity, nonlinearity, structural limit). In the first part, we propose two control schemes by polytopic LPV (Linear Parameter Varying) approach and by Strong Stabilization with genetic algorithm optimization to solve the comfort/handling and comfort/suspension travel conflits. In the second part, to solve the full semi-active suspension problem, we develop first a generic strategy for general LPV systems subject to actuator saturation and state constraints. The problem is studied in the form of resolution matrix of linear inequalities (LMI) that allows synthesizing an LPV controller and an anti-windup gain to ensure the stability and performance of the closed-loop system. Second, the theoretical result is applied to the case of semi-active suspension control. The proposed methods are validated by an evaluation based on an industrial standard and simulations on a nonlinear quarter vehicle model
Abdali, Saba. "Flyktens inverkan på kvinnors liv : En kvalitativ studie om hur kvinnliga flyktingar upplever att de kan forma sina liv i den svenska staten." Thesis, Uppsala universitet, Statsvetenskapliga institutionen, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-352361.
Jaanson, Jenny. "Vardagens sociala liv för föräldrar till ett barn med psykossjukdom - fem föräldrars erfarenheter." Thesis, Linnéuniversitetet, Institutionen för socialt arbete, SA, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-13301.
Akram, Ghorbani. "Får jag lov att vara annorlunda? : en vetenskaplig essä." Thesis, Södertörns högskola, Institutionen för kultur och lärande, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-21875.
Nguyen, Manh Quan. "LPV approaches for modelling and control of vehicle dynamics : application toa small car pilot plant with ER dampers." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAT091/document.
Semi-active suspension system plays a key role in enhancing comfort and road holding of vertical dynamics in automotive vehicles. This PhD thesis research work, focused on that topic, is divided into two main parts. The first one considers the semi-active suspension control problem, the main challenge of which being to handle the dissipativity constraint and suspensions stroke limitation of semi-active dampers. These constraints are recast into input and state constraints in a linear state space representation. Thereby, the semi-active suspension control is designed in the framework of Linear Parameter Varying (LPV) approach with input constraints, and of Model Predictive Control (MPC) approach.The second part is devoted to Fault Estimation and Fault Tolerant Control (FTC) in case of actuator fault, and its application to Semi-Active suspension systems. The fault considered here is the loss of actuator's efficiency (due to an oil leakage of the damper for instance when a ), which is estimated using several observer-based approaches. Then, thanks to the fault information from the estimation step, an LPV/FTC fault scheduling control is designed to limit the vehicle performance deterioration
Do, Anh lam. "Approche LPV pour la commande robuste de la dynamique des véhicules : amélioration conjointe du confort et de la sécurité." Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00822010.
Salameh, Jack. "Approche par contrôle actif dans le cadre de l'optimisation de la durée de vie des éoliennes." Thesis, La Rochelle, 2019. http://www.theses.fr/2019LAROS026.
This thesis entitled "Active control for wind turbine lifetime expectancy optimization" studies the operation of wind turbines and aims to reduce disturbance through an active control strategy. Wind turbines are known to operate under harsh environmental conditions mainly related to random wind speeds. The wind profile induces two disturbance components known as the wind shear and tower shadow. These components produce a disturbed aerodynamic torque causing stress, fatigue, and mechanical component failure. Chapter 1 introduces the wind turbine theory and all related mechanical and electrical subsystem. The extended Kalman filter (EKF) is then introduced to show the necessity of signal processing and diagnosis for disturbance isolation and detection. Chapter 2 presents a new modified Sliding Window Empirical Mode Decomposition (SWEMD) method as a signal processing method capable of better isolating the disturbance component. It is concluded that after the SWEMD one can accurately diagnose the wind shear and tower shadow disturbance frequency signature. In chapter 3 an estimation method based on the Unknown Input Observer (UIO) is applied in order to estimate the disturbance in the wind turbine. The UIO shows great results in accurately estimating the disturbance. Chapter 4 introduces the active control Linear Parameter Varying (LPV)-based strategy for torque ripple attenuation. The isolated disturbance by the SWEMD, and the estimated disturbance through the UIO are used as the LPV control input in order to generate a current control command. The control command is then injected into the generator in order to reduce the disturbance effect on the drivetrain. For both isolation and estimation results show good aerodynamic disturbance attenuation, while the UIO showed better results than those of the SWEMD. Chapter 5 presents the experimental setup used to validate the theoretical work. A test bench at the University of Poitiers is used to imitate the operation of the wind turbine. All the results matched the ones found in the theoretical tests
Tinard, Sophie. "Effets des connaissances sur les souvenirs épisodiques : approche comportementale et neurophysiologique." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0652/document.
Dual-process models of recognition postulate that two independent processes sustained recognition (familiarity and recollection) while single process models consider the familiarity and the recollection as the ends of a continuum reflecting a common process. For now, dual-process models are the most accepted, due to electrophysiological evidences of two distinct components, FN400 and LPC, which have been linked to familiarity and recollection, respectively. However, a debate is growing concerning the independence of these components. The main objective of this thesis was to investigate familiarity, recollection and their neural correlates’ nature. To this end, we studied the influence of perceptual (study 1 and 2), semantic (all study), associative information (study 1 and 2), the repetition (study 3) and the age-related effect (study 4) on familiarity, recollection and corresponding neural correlates using ROC and EEG data. Results support the view that familiarity, as reflected by FN400, is multi-determined but allow to specify the conditioned the hierarchy in the information’s processing: perceptual then semantic and then associative. Recollection, as reflected by the LPC, would also be multi-determined, but was mainly influenced by semantic and associative information and then, in a secondary way, by perceptual information. Taken together, present data support the redundancy model suggesting that familiarity and recollection depend on a common, multi-determined and dynamic process
Yang, Dapeng. "Approche algébrique pour l’analyse de systèmes modélisés par bond graph." Thesis, Ecole centrale de Lille, 2012. http://www.theses.fr/2012ECLI0007/document.
The control synthesis of physical systems is a complex task because it requires the knowledge of a "good model" and according to the choice of a model some specific tools must be developed. These tools, mainly developed from a mathematical and theoretical point of view, must be used from the analysis step (analysis of model properties) to the control synthesis step. It is well-known that in many approaches, the properties of the controlled systems can be analyzed from the initial model. If the system is described with an input-output representation or with a state space representation, two kinds of information are often pointed out: the external structure (infinite structure) and the internal structure (finite structure). The first one is often related to the existence of some control strategies (input-output decoupling, disturbance decoupling...) and the second one gives some focus on the stability property of the controlled system.In this report, the focus has been on the study of invariant zeros of bond graph models in the context of LTV models. The algebraic approach was essential because, even if the problem is already solved for LTI bond graph models, the extension to LTV models is not so easy. The simultaneous use of algebraic and graphical approaches has been proven to be effective and convenient to solve this problem. First, some tools from the algebraic approach have been recalled in chapter one and results for the study of invariant zeros of LTI bond graph models recalled in chapter two. Some new developments are proposed in chapter three and some applications for the unknown input observer problem with some physical applications conclude this work
Oudainia, Mohamed Radjeb. "Contrôle partagé adaptatif et élaboration de stratégies de conduite personnalisées pour le véhicule automatisé : une approche par apprentissage progressif." Electronic Thesis or Diss., Valenciennes, Université Polytechnique Hauts-de-France, 2023. http://www.theses.fr/2023UPHF0038.
Autonomous driving technology is attracting increasing interest from automobile manufacturers, researchers, authorities, and the general public due to its promises in enhancing road safety, providing mobility for the elderly and individuals with reduced mobility, improving energy efficiency, and reducing emissions. However, the full deployment of these vehicles relies on their reliability in all situations, necessitating driver supervision. This raises critical questions about human-machine interaction, particularly concerning sharing control between the automated driving system and the driver, as well as conflict management.The thesis is part of the ANR-CoCoVeIA project (2019-2024), coordinated by LAMIH (Cooperation Driver-Autonomous Intelligent Vehicle). The main objective of this project is to introduce self-learning capabilities into level 2 autonomous vehicles to enhance their skills while adhering to road safety rules. The thesis focuses specifically on managing interactions between the automated system and the driver, with the goal of improving its effectiveness, enhancing driving performance, and promoting the driver's acceptance of the system.To achieve these goals, a multi-level evolutionary cooperation architecture is proposed in the first part of the thesis. This architecture aims to optimally adapt the behavior of the autonomous vehicle to a driver's preferred driving style while ensuring safe and efficient driving. The second part of the thesis delves into personalizing lane change assistance systems, using a stochastic gradient descent-based learning approach to adjust parameters based on the driver's preferences, relying on the detection of their lane change intentions.To address conflicts between the driver and the autonomous driving system, the thesis explores three robust optimal control approaches for linear time-varying parameter systems (LPV) represented in the Takagi-Sugeno (T-S) fuzzy form. The first approach focuses on adaptive shared control by real-time adjustment of a multi-objective cost function based on driver availability and risk assessment. The second approach introduces a driver's dynamic model, with parameters identified online, allowing continuous adaptation to the driver's characteristics. This model is used to develop an adaptive shared control system for lane-keeping, taking into account the neuromuscular dynamics of the driver's parameters. The final approach aims to entirely eliminate conflicts between the driver and the lane-keeping system by combining an adaptive cost function with a dynamic driver behavior model.For the design of the LPV shared controller, stability conditions for closed-loop adaptive shared control (LPV) for all three approaches are established using Lyapunov stability arguments and formulated as a linear matrix inequality (LMI) optimization problem that can be numerically solved using convex optimization algorithms. Experimental validations and user testing experiments were conducted using the SHERPA-LAMIH dynamic driving simulator to assess the acceptability of these approaches, demonstrating their effectiveness in improving safety and driving comfort and validating all of the proposed approaches
Nilsson, Jonas, and Tommy Regin. "Frågan om den samhällsnyttiga medborgaren : En analys av diskursen i utredningarna som föregick Lgy 70 och Lpf 94." Thesis, Linnéuniversitetet, Institutionen för pedagogik (PED), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-31870.
The purpose of this paper was to examine the Swedish school policies that formed the basis for the curriculums Lgy 70 and Lpf 94. Specific focus was on finding the governing effects in the exanimated material by extracting its view on humans and knowledge. The method used was Carol Lee Bacchi’s What’s the problem represented to be?-approach. With this method authors conducted an analysis of the discourse in the material. The investigation of the material found that the overall problem concerning the Upper secondary school was their portrayal as outdated and non-adaptive to the society of that time. However, a group of students were represented to be the problem to which the school needed to adapt. The content of the group differed between the two time-periods (the 1960s and the 1990s), but the group included those who were not capable of managing the school of that time. The solutions to the, by the investigations assumed problem, were directed towards this group of student and resulted in an increased freedom of choice for them. This freedom of choice was however a control strategy used by the government to direct student towards a, by the government considered, “proper” education. The underlying view of humans and knowledge was a behavioural one. The exanimated investigations assumed that young people were largely influenced by their background and social class in their choice of education. In conclusion the Swedish upper secondary school were adapted to the demands of the labour market. Education was considered to make the students more qualified for their future life as workers. The school needed to adapt to those who were not capable of this.
Wahlberg, Elisabeth. ""... och så har jag ju alltid morsan som kan hjälpa mig" : Om unga vuxnas strategier för att hantera sina läs- och skrivsvårigheter i dagligt liv." Thesis, Mälardalens högskola, Akademin för utbildning, kultur och kommunikation, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-12993.
Effeney, Gerard. "A case study investigating changes in students' approaches to learning when exposed to teaching strategies aimed at promoting metacognitive learning." Thesis, Australian Catholic University, 1994. https://acuresearchbank.acu.edu.au/download/6d64d83151bea85db890d23c64cf0cb43a9ac7d318709726568675bd8e466abb/6376502/Effeney_1994_A_case_study_investigating_changes_in.pdf.
Andaloussi, Chafik. "Propriétés structurelles des systèmes linéaires à paramètres variant dans le temps : approche bond-graph." Ecole Centrale de Lille, 2007. http://www.theses.fr/2007ECLI0004.
This thesis aims at the study of the structural properties on the bond-graph models. The principal motivation is to contribute to the resolution of the problems related on the study of the structural properties and calculation of the inverse system of a LTV system using of the properties and the advantages offered by a graphical representation such as the bond-graph. These problems are approached in the case of linear bond-graphs models with time varying parameters and the adequate tools were proposed. To achieve these goals, new concepts and tools were introduced. In particular, defining the concept of noncommutative bond-graph ring, a new gain rule known under the name of “Riegle rule” is introduced in bond-graph. In addition, thanks to the introduction of the notion of the differential algebra and using of the operators (delta and sigma), it became possible to graphically calculate the terms of the matrices of commandability/observability by using appropriate rules based on calculation length of the causal paths inputs-states/states-outputs. It is also shown that the graphic rules of the study of the infinite structure remain applicable in a bond-graph ring. Finally, to go further in the introduction of the algebra tool and modules to the bond-graphs, the study of the properties of inversibility of a bond-graph ring model was approached. In this context and basing on the disjoint input-output causal paths notion, it is possible to make an analysis of the inversibility directly from its BG model. It is also shown that the bicausality concept and graphic determination of the differential parameterization by using the rule of Riegle are made possible
Yang, Dapeng. "Approche algébrique pour l'analyse de systèmes modélisés par bond graph." Phd thesis, Ecole Centrale de Lille, 2012. http://tel.archives-ouvertes.fr/tel-00735082.
Schwudke, Dominik. "Biochemical and genetic approaches for the characterization of Bdellovibrionaceae, unique predatory bacteria." Doctoral thesis, [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=970402368.
Chalh, Zakaria. "Approche algébrique et graphique pour l'analyse des modèles Bond Graph." Ecole Centrale de Lille, 2008. http://www.theses.fr/2008ECLI0002.
The objective of this dissertation is to study the structural properties of linear time varying dynamic systems from their bond graph model and their equivalent module. After a brief reminder of the theory of modules and structural properties of systems by LTI bond graph approach, the various methods used to study the structural properties and their interpretation by the theory of modules, a comparison between the two approaches is proposed. To achieve these objectives, we used tools and concepts such as the notion of ring non-commutative bond graph, the principle of duality on linear time varying systems and bicausality. Thanks to these concepts we have introduced new methodologies. In particular, a new graphic rule for calculating the elements of the controllability and observability matrix, the calculation of the non ordered representing the torsion sub-module of the system equivalent torsion module, and with the principle of duality we deduce the non-observable from the calculation of the non controllable part of the dual system. We propose a graphic method of formal calculation of the invariants zero of systems LTV by using the principle of the bicausality what enables us to apply certain constraints. The determination of the non-controlled and non-observable helps us determine the zeros decoupling inbound and outbound
Stephens, Nathan Wallace. "A Comparison of Microarray Analyses: A Mixed Models Approach Versus the Significance Analysis of Microarrays." BYU ScholarsArchive, 2006. https://scholarsarchive.byu.edu/etd/1115.
Ferrero, Frédéric. "Approche physio-pathologique et exploitation génétique de l'expression de la résistance à l'oïdium (sphaerotheca pannosa lev. , var. Rosae) dans le genre Rosa." Avignon, 2005. http://www.theses.fr/2005AVIG0314.
Powdery mildew of the rose tree induces heavy economic consequences. This disease is due to an external fungus Sphaerotheca pannosa var. Rosae that develops on the host without resulting in his death. This work of thesis points out a study in four steps of the relations host-parasite : 1- the evaluation of the expression of the symptoms of powdery mildew, in two collections, one of botanical species and another of modern rose trees. This approach allowed to identify resistant genotypes. 2- a program of crossings to evaluate the transmission of resistance and abilities for combination. The observation of the segregations, on the progenies from a diallele crossing plan between diploid species, confirmed that the character of resistance was controlled by several genes. The process for introgression of resistance, via a dihaploïd (2x) of modern rose tree (4x) cross with R. Wichuraïana (2x) followed with serial brother-sister crossings revealed as essential to fix the character. 3- the search for tools of sifting. This one led to a biological test of evaluation of resistance to powdery mildew and to methods for the isolation of the inoculum and following for the obtainment of mono-conidial isolates. 4- the study of the installation of the foliar cuticle and its efficiency according to : genotype, age of the organ and environmental conditions. A process was established to modulate the installation of the cuticle on plantlets resulting from in vitro. The cuticular evapotranspiration of resistant genotypes was measured lower than that of sensitive. At last, high calcium level in the nutrition of rose tree would activate the biosynthesis of the cuticle. In conclusion, the whole of these results contributes to the knowledge of the disease and to the definition of a strategy for the selection of the character of Resistance to powdery mildew
Gallab, Maryam. "Développement d’une approche d’aide à la maitrise des risques dans les activités de maintenance d'une chaine logistique : Approche par modélisation et simulation basée sur les systèmes multi-agents." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEM028/document.
The main objective of this thesis is to develop a multi-agent approach to designing a model to overcome risks of maintenance activities. The aim is to explore the maintenance complexity and to indicate the interactions between the maintenance function and the risk assessment.Firstly, we are interested in designing a systemic model to identify and model the industrial system, to show the different interactions between its elements, to analyze and to evaluate risks of maintenance activities. We propose the MOSAR method and the UML language to design a cognitive reference model. This model served as a starting point for designing a database using the SQL language, which is operated by Multi-Agent model to acquire the necessary information for its operation.On the other hand, we develop a framework of a multi-agent system that aims to anticipate failures scenarios and the decision-making by simulating the studied system behaviour. A comparison between the existing platforms dedicated to Multi-Agent Systems is performed to choose the appropriate platform for the simulation.Finally, the developed models are applied in the LPG supply chain (Liquefied Petroleum Gas). A simulator was developed using the AnyLogic platform in order to study the system behaviour and to simulate the failure scenarios chosen by the industry, for the calculation of the criticality from three parameters (Frequency, severity, detectability), and for obtaining a Dashboard containing a set of maintenance performance indicators. The proposed simulation models help to guide the industries toward good decisions to avoid risky situations that may trigger disruptive events damaging
Rohaut, Benjamin. "Relations entre conscience et représentations sémantiques verbales : approche comportementale et neurophysiologique chez le sujet sain et le patient cérébro-lésé." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066413/document.
The study of cognitive functions so complex such as language and consciousness, and of their interactions, is a challenge at the boundaries between medicine (intensive care, anesthesia, neurology) and cognitive neuroscience. Semantic processing provides our perceptual experiences with a level of abstraction allowing a variety of conceptual functions such as object recognition, social cognition, or language. In this thesis, we explored the relationships between verbal semantic processing and consciousness using a double approach: first, by studying healthy subjects in conscious and unconscious condition (using visual masking), and secondly by studying patients with disorders of consciousness. Through this work we provided empirical evidence of unconscious semantic representations. We then proposed that the two main brain signatures of semantic processing observed in ERPs (N400 and LPC / P600) could be integrated in a two stages model: a first unconscious stage (corresponding to the N400), followed or not by a second stage of processing corresponding to conscious semantics (LPC / P600). Exploring the differences between conscious and nonconscious processing, we showed that nonconscious semantic processing is sensitive to conscious top-down influences. These results refute a strictly automatic conception of unconscious cognition. Our results also shed new light on the respective roles of the two hemispheres in the resolution of semantic ambiguity. The exploration of high-level cognitive abilities, - such a verbal semantic processing - in patients affected with disorder of consciousness should enable significant advancements in their medical management
Raab, Raphaelle. "Vers une pédagogie des temps faibles : étude sur les processus d'autonomisation en classe maternelle dans le cadre des espaces-temps intersticiels." Thesis, Lyon 2, 2015. http://www.theses.fr/2015LYO20046/document.
This dissertation studies favorable conditions to empowerment of pupils. The empirical study was carried out in the final year of kindergarten. In most learning/teaching situations, "autonomy moments" are structurally inevitable since the teacher cannot be systematically available to everyone all the time. Interest is focused on moments during which the teacher does not directly intervene, either because he/she is not available or because he/she voluntarily withdraws from the learning situation. We call these moments "low times" because of the teacher's low presence: during these specific moments, each student responds according to his own strengths without the teacher's direct intervention to regulate both learning and behavior. It appears that students are not naturally autonomous: when left unattended, the so-called "autonomous" learning activities contribute to widening the knowledge gap between students in learning situations. Autonomy would be part of this implicitly expected behavior and is "all the more expected and required from teachers rather than being constructed in, with and by school". How can student empowerment be perceived and operationalized in an ordinary class context? Our goal is to identify tools, levers, interactions and devices which enable students to benefit from "low times" for their own learning. The data are collected in 14 classes in 117 half-days of direct observation. Socio-constructivist approach to learning suggests that in order to construct new knowledge, the student must encounter an obstacle in the course of accomplishing his task. Learning results from overcoming this obstacle. We highlight differentiated behaviors of students when facing obstacles in autonomy classroom workshops: some resort to avoidance strategies and refuse to deal with this obstacle by bypassing or circumventing it. Conversely, others draw on (their own) resources in order to overcome it and construct new knowledge. During the study period, remarkable dynamics appear: some students, with usually an "avoidant" attitude, join or maintain a "drawing on resource conduct". The study of the "notable exceptions" leads to the emergence of the favorable conditions which fostered this particular dynamic in terms of tools, activities, interactions and devices. What would have worked to the benefit of the notable exceptions could be further used as a sustainable and pedagogical lever to the benefit of all students. These conditions become then supposedly favorable and are reinvested in experimental devices in order to see if they produce the expected effects, to which extent and within what limits? Il clearly appears that the empowerment process, in classroom context of a large and heterogeneous class, is developed in a special way in "low times" of pedagogical structuration and their articulation with "strong times", notably collective feedbacks on workshops. A pedagogy of "low times" entails providing the teacher with substantial pedagogical status, which would be a crucial step as well as an instrument in the school empowerment process. Such pedagogy would also entail carefully organizing teacher's intervention in an indirect mode, through a class device which would relay it through its various dispositions (tools, rules, activities, interactions). The student would then internalize these dispositions as psychological instruments in referring to oneself in the first person. This pedagogy would finally entail a redefinition of teacher's role: his/her apparent "absence" from the situation which would paradoxically become, a teaching-learning tool to the benefit of school empowerment
Beckman, Bradley. "Ronald Stevenson's Passacaglia on DSCH: Understanding the Composer's Unique Approach to Large-Scaled Structure, a Lecture Recital, together with Three Recitals of Selected Works of L.V. Beethoven, J. Brahms, F. Liszt, F. Mendelssohn, B. Bartók and Others." Thesis, University of North Texas, 1994. https://digital.library.unt.edu/ark:/67531/metadc279229/.
Huang, Botao. "Mécanismes de vieillissement de l'Assemblage-Membrane-Électrodes dans une pile à combustible de type PEM par approche expérimentale." Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0268/document.
This thesis highlights the aging mechanisms of PEM Fuel Cell submitted to two main aging conditions: air relative humidity (RH) cycling, and MEA (Membrane Electrode Assembly) pinhole test of operation. First, the aging mechanisms of PEMFC main components (membrane, catalyst, carbon support, GDL, bipolar plates and gaskets), have been reviewed from the literature. Then the on-line diagnostic tools (chronopotentiometry, electrochemical impedance spectroscopy, water management and water analysis), off-line ones (cyclic voltammetry and linear sweep voltammetry) and post-mortem analyses (nuclear magnetic resonance, transmission electron microscopy, scanning electron microscopy and X-ray diffraction) have been described. Experimentally, the high and low air RH cycling runs have been carried out with a 25 cm2 single cell: the high air RH cycling run promoted serious loss of the ElectroChemical Surface Area (ECSA); the low air RH cycling run caused significant increase in hydrogen crossover. The low air RH cycling has been also performed with a 100 cm2 single cell and the aging mechanism was different from that of 25 cm2 cell: the hydrogen crossover remained very low but the fuel cell voltage exhibited strong fluctuations at the end of the run: this was attributed to the presence of dead volumes and liquid water retention within the cell. Finally, MEA pinhole effect has been investigated with a 100 cm2 single cell: the perforation by a 0.7 mm diameter pin promoted slight increase in the hydrogen crossover; the perforation by a 1.2 mm diameter pin caused significant cell voltage losses and serious increase in the cathode diffusion resistance due to significant hydrogen crossover
Carneiro, Maria Sylvia Cardoso. "Deficiência mental como produção social : uma discussão a partir de histórias de vida de adultos com síndrome de Down." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/10829.
This piece of research argues that mental deficiency is a condition that arises from social relations established with individuals who present unique characteristics in relation to the major part of population, and not as incapability. Based on a historical-cultural approach, this standpoint goes against traditional concepts of mental deficiency, especially that one informed by Vigotski. Notwithstanding any structural or functional organic alteration in the nervous system, a subject develops himself/herself through social relations – not as a mental handicap. As regards the methods, the story lives’ reports have been used of three adults with Down syndrome, who claimed to be mental deficiency-free. The three of them have been educated in regular schools, in Brazil and Spain, up to undergraduate level. These reports may portray that people develop themselves from interactions established in their groups and according to material resources available, despite their disfavorable organic conditions. Using narrative methods in research on mental deficiency enables one to acknowledge research subjects as actors and authors of their own story. In order to obtain data, target subjects have been interviewed, and mentors and relatives have also supplied additional information, always with respect to the specificities of each case. It was possible to identity challenge apropos the prognostics of mental deficiency and low education level in the three stories in the three different contexts and their very peculiar conditions. Social compensation processes seem to have enabled surpassing limits, which are taken as unsurpassable still in the present. Additionally, this research sought to comprehend constitutive elements of the subjects’ trajectory aforementioned. Directional axes’ analyses involved: breaking down negative prognostics, shaping up varied development possibilities, being educated at regular schools, the self-image each one presented, relations established in their workplace. Looking close at these and other breakthrough stories may help us reassure that one constitutes him/herself a human being relating to others, albeit disfavorable conditions.
Este trabajo presenta un estudio cuyo objetivo central es discutir la deficiencia mental como condición que se desarrolla a partir de las relaciones sociales establecidas con individuos que presentan características singulares en relación a la mayoría de la población y no como una incapacidad propia. Esta visión es contraria a las concepciones tradicionales de deficiencia mental y se apoya en el abordaje histórico/cultural, especialmente en las contribuciones de Vigotski. La idea básica es que, aún frente a cualquier alteración orgánica, aunque ésta sea a nivel estructural o funcional del sistema nervioso, será por y en las relaciones sociales que el individuo se desarrollará, o no, como deficiente mental. Como estrategia metodológica, se utilizaron relatos de historias de vida de tres adultos con síndrome de Down que se constituyeron como individuos sin deficiencia mental. Los tres estudiaron en escuelas comunes, en diferentes contextos de Brasil y de España, llegando a la enseñanza superior. Estas historias pueden mostrar que, aún en presencia de condiciones orgánicas adversas, las personas se desarrollan a partir de las interacciones que establecen en sus grupos y de las condiciones materiales de vida. El uso de métodos narrativos en estudios sobre la deficiencia mental facilita el reconocimiento de los individuos del estudio como actores y autores de su historia. En el caso de este estudio, se realizaron repetidas entrevistas con los individuos específicos, además de buscar informaciones complementarias, con profesores y familiares, respetando las especificaciones de cada caso. Viviendo en diferentes contextos y de formas muy peculiares, se puede identificar en las tres historias el desafío a los pronósticos de deficiencia mental y de baja escolaridad, mostrando procesos de compensación social que permitieron la superación de límites, aún hoy vistos como infranqueables. Se ha buscado comprender los movimientos constitutivos de las trayectorias de esos individuos por medio del análisis de ejes de sentido que involucraron: la ruptura con los pronósticos negativos y la construcción de otras posibilidades de desarrollo, el estudio en la escuela común, la imagen que cada individuo muestra de sí mismo y las vivencias en el mundo del trabajo. La mirada atenta a estas y a otras historias de ruptura nos puede ayudar a reafirmar que la constitución del ser humano en “humano”, aún en condiciones de desventaja, se da en la relación con los demás.
Benamar, Mohamed Amine. "Développement d’une approche numérique et expérimentale par la mesure VLD pour la propagation acoustique mutimodale en conduit avec écoulement." Thesis, Compiègne, 2021. http://www.theses.fr/2021COMP2624.
Laser Doppler Velocimetry (LDV) is a non-intrusive measurement of particle velocity classically used in fluid mechanics. The acoustic velocity is a very important quantity in acoustics for the characterization of acoustic propagation fields, which is essential for the understanding of certain propagation phenomena in near walls or for complex geometries. The DUCAT bench installed in the laboratory of the Acoustics and Vibration team of the University of Technology of Compiègne aimed at characterizing the acoustic performances of various acoustic absorption systems such as SDOF or metallic porous materials for aeronautical uses through the measurement of the acoustic velocity and pressure through two automated probes containing a hot wire sensor as well as a microphone with ogive. The objective of this thesis is to allow the measurement of acoustic velocity in multimodal propagation and in the presence of flow using the VLD. The signal measured by the VLD is randomly sampled and has a fairly large background noise due to the presence of flow in the duct. The complex nature of the measured signal requires special signal processing methods to extract the acoustic velocity that is important to us. The first part of this thesis presents a benchmark of the different methods available in the literature and their validity for the current experimental conditions of the DUCAT bench. A simulation of the measured VLD signal is developed as a reference to validate the methods, whether they are spectral or temporal. The weighted least squares method is finally selected and adapted following this study for the estimation of the various acoustic parameters from the raw signal. The second part concerns the presentation of the numerical tools used or developed for the simulation of the acoustic propagation in infinite ducts. The main numerical tool is an aeroacoustic finite element code developed in the lab based on Galbrun’s equations coupled to a virtual absorbing layer called PML (Perfect Matched Layer). Due to the presence of the PML, the numerical solution of the inverse problem becomes complicated, which led us to develop a code for solving nonlinear eigenvalue problems based on the Integral Contour method. The third part of this work presents the different components of the modified version of the bench as well as the characteristics of these different components. The bench allows the experimentation of multimodal acoustic propagation (up to 5000 Hz) in the presence of a suction/expiration flow that can reach a speed of Mach 0.25. The fourth and last part, presents a protocol of experimental numerical validation of all the tools presented and developed. The test/calculation comparisons are presented for a multimodal propagation in a straight duct at first. The results allow to conclude on the efficiency of the measurement and signal processing system with a relative error lower than 1 dB. The same protocol is then used for the experimental study of the acoustic trapped modes in the case of a cylindrical duct with an abrupt change of section
Huang, Yun. "Nonlinear optimal control: an enhanced quasi-LPV approach." Thesis, 1999. https://thesis.library.caltech.edu/1917/1/Huang_y_1999.pdf.
Qin, Wubi. "Feedback performance control for self-managing computer systems an LPV control theoretic approach /." 2007. http://www.etda.libraries.psu.edu/theses/approved/WorldWideIndex/ETD-1958/index.html.
Zhang, Hai. "Robust LPV control of a magnetic bearing suspension system with a convex optimization approach /." 2003. http://wwwlib.umi.com/dissertations/fullcit/3083092.
McCloy, Ryan. "A set-theoretic approach to sensor fault tolerant control of constrained linear parameter varying systems." Thesis, 2018. http://hdl.handle.net/1959.13/1398743.
One of the traditional motivators for the use of constrained optimisation in control systems has been its ability to handle safety constraints and equipment limitations over conventional control technologies, whereby operation close to such constraints is often most profitable or efficient. Driven by this, combined with advances in computing power and the development of analytical tools, academic interests have paved the way for expanding practical applications. In competitive markets where efficiency and performance are key, optimisation based control techniques are becoming increasingly popular. Although linear analysis and control tools have been widely studied, nonlinear solutions are still largely under development. The linear parameter varying framework is attractive as it allows for the use of powerful linear design tools to a wide range of complex nonlinear systems. Linear parameter varying models also have a close relationship with gain-scheduling control, which is a well-defined control strategy for a large class of nonlinear systems. The development of techniques to assess linear parameter varying system stability has also motivated the use of this modelling paradigm. Many of these techniques allow for the use of efficient computation methods, such as linear matrix inequality based routines. Whilst performance requirements are essential, another key feature to modern control system design is the robustness and stability of the design. With a heavy reliability upon the plant model in optimised control, it is significantly important to be able to efficiently handle a range of possible system faults/failures. With this in mind, exploration of new methodologies to ensure closed-loop stability, constraint satisfaction and robustness of design to system faults is a lively, interesting and useful topic for modern control system designers. The problems of stability, robustness, and fault tolerance, especially in model predictive control, are very much open problems for nonlinear systems, with no well-defined solution. As such, there is a great realm of opportunity for research and contribution to these areas. This thesis is then concerned with the development of sensor fault tolerant control strategies for mulitsensor constrained linear parameter systems. Fault tolerance is achieved via an invariant set-theoretic approach, in which, appropriately selected residual variables converge to sets based on the healthy or faulty behaviour of corresponding sensors. The established methodologies incorporate this set-based fault detection and isolation strategy combined with an estimate-based controller reconfiguration. Full mathematical description and proof for the robust stability of systems with convex polytopic uncertainty through the construction of attractive invariant sets is obtained. This result is an adaptation from switched systems and is particularly useful for systems modelled using the linear parameter varying framework. Initially, faulty sensors are detected and discarded from the control law utilising the developed analytical tools. The problem and comparison of several solutions of estimating convergence times to invariant sets is investigated as an extension of the set-theoretic tools. Using convergence time estimates, the overall approach is then naturally progressed to permit sensor reintegration, by detecting and tracking the transitions and set-membership of residual signals associated with faulty and recovered sensor behavior. Continuing with the set-theoretic nature of the overall approach, a tube-based model predictive controller is then integrated into the design methodology to provide constraint satisfaction. Driven by a tube-based model predictive control generated reference, conditions are formulated which guarantee satisfaction of hard constraints by defining tubes with cross sections that will contain the predicted state trajectory. Under this approach, bounded disturbances and model uncertainty can also be accounted for by forcing the nominal system to adhere to tighter constraints. Hence, this thesis provides certificates for assessing the robust stability of constrained linear parameter varying systems, in the presence of disturbances, model uncertainty, sensor faults and sensor recovery. Capabilities for instantaneous fault detection and guaranteed closed-loop stability in the presence of hard constraints is provided, whilst permitting the reintegration of recovered sensors with guaranteed convergence times. Simulated and experimental verification of the developed strategies is provided to demonstrate the performance characteristics and preservation of closed-loop stability through the implementation and testing of targeted applications. Although linear analysis and control tools have been widely studied, nonlinear solutions are still largely under development. The linear parameter varying framework is attractive as it allows for the use of powerful linear design tools to a wide range of complex nonlinear systems. Linear parameter varying models also have a close relationship with gain-scheduling control, which is a well-defined control strategy for a large class of nonlinear systems. The development of techniques to assess linear parameter varying system stability has also motivated the use of this modelling paradigm. Many of these techniques allow for the use of efficient computation methods, such as linear matrix inequality based routines. Whilst performance requirements are essential, another key feature to modern control system design is the robustness and stability of the design. With a heavy reliability upon the plant model in optimised control, it is significantly important to be able to efficiently handle a range of possible system faults/failures. With this in mind, exploration of new methodologies to ensure closed-loop stability, constraint satisfaction and robustness of design to system faults is a lively, interesting and useful topic for modern control system designers. The problems of stability, robustness, and fault tolerance, especially in model predictive control, are very much open problems for nonlinear systems, with no well-defined solution. As such, there is a great realm of opportunity for research and contribution to these areas. This thesis is then concerned with the development of sensor fault tolerant control strategies for mulitsensor constrained linear parameter systems. Fault tolerance is achieved via an invariant set-theoretic approach, in which, appropriately selected residual variables converge to sets based on the healthy or faulty behaviour of corresponding sensors. The established methodologies incorporate this set-based fault detection and isolation strategy combined with an estimate-based controller reconfiguration. Full mathematical description and proof for the robust stability of systems with convex polytopic uncertainty through the construction of attractive invariant sets is obtained. This result is an adaptation from switched systems and is particularly useful for systems modelled using the linear parameter varying framework. Initially, faulty sensors are detected and discarded from the control law utilising the developed analytical tools. The problem and comparison of several solutions of estimating convergence times to invariant sets is investigated as an extension of the set-theoretic tools. Using convergence time estimates, the overall approach is then naturally progressed to permit sensor reintegration, by detecting and tracking the transitions and set-membership of residual signals associated with faulty and recovered sensor behavior. Continuing with the set-theoretic nature of the overall approach, a tube-based model predictive controller is then integrated into the design methodology to provide constraint satisfaction. Driven by a tube-based model predictive control generated reference, conditions are formulated which guarantee satisfaction of hard constraints by defining tubes with cross sections that will contain the predicted state trajectory. Under this approach, bounded disturbances and model uncertainty can also be accounted for by forcing the nominal system to adhere to tighter constraints. Hence, this thesis provides certificates for assessing the robust stability of constrained linear parameter varying systems, in the presence of disturbances, model uncertainty, sensor faults and sensor recovery. Capabilities for instantaneous fault detection and guaranteed closed-loop stability in the presence of hard constraints is provided, whilst permitting the reintegration of recovered sensors with guaranteed convergence times. Simulated and experimental verification of the developed strategies is provided to demonstrate the performance characteristics and preservation of closed-loop stability through the implementation and testing of targeted applications.
Hamdi, Habib. "Approche Multi-Modèle pour l'Observation d'état et le Diagnostic des Systèmes Singuliers Non Linéaires." Phd thesis, 2012. http://tel.archives-ouvertes.fr/tel-00757821.
Pathak, Gopal Prasad [Verfasser]. "A metagenomic approach towards novel LOV domain containing blue-light photoreceptors / vorgelegt von Gopal Prasad Pathak." 2010. http://d-nb.info/1006921540/34.
Gameiro, Mafalda Martins de Campos. "A person-centred approach to the job demands-control model : testing strain and learning hypotheses through lpa." Master's thesis, 2018. http://hdl.handle.net/10451/36771.
We used a cross-sectional design and a person-centred approach in order to test the strain and learning hypothesis of Karasek’s Job Demands-Control Model among a sample of Portuguese nurses, bankers, retail traders and contact centre employees (n = 5641). Through Latent Profile Analysis (LPA), we first identified latent profiles of demands and control and then examined how these groups differed in well-being (engagement, exhaustion and cynicism levels) and motivation- related outcomes (engagement), through an ANCOVA. LPA revealed five profiles: “High-strain”, “Moderate-strain”, “Moderate Active”, “Moderate” and “Active”. The strain hypothesis was supported in both direct effects and interactive effects (buffer hypothesis), suggesting that the difficulty in finding consistent support for the buffer hypothesis might be related to the use of variable-centred approaches. Moreover, this shows that, in organizational practice, if control is provided there is no necessary need in reducing demands at work, as control will buffer demands’ harmful effects on well-being. Learning hypothesis could not be tested due to the fact that a Passive profile was not found in this sample. However the comparisons between the “Active” and the “Moderate” profiles suggests that motivation is higher in the presence of both high job demands and control. This leads us to believe that when people are presented with considerable demands and have control over they jobs, they will be more motivated to grow professionally and consequently obtain better outcomes.
Utilizou-se um desenho experimental transversal e uma abordagem centrada na pessoa por forma a testar a hipóteses de strain e a hipótese de aprendizagem propostas no Modelo de Exigências e Controlo (Job Demands-Control Model) de Karasek. Para tal, usou-se uma metodologia de análise de perfis latentes numa amostra de enfermeiros, bancários, comerciais de retalho e empregados de contact centre portugueses (n = 5641), para identificar os perfis latentes de exigências e controlo. Dessa análise surgiram cinco perfis: “High-strain”, “Moderate-strain”, “Moderate Active”, “Moderate” e “Active”. A seguir, através de uma ANCOVA examinou-se como é que estes grupos diferiam em termos de bem-estar (i.e. engagement, exaustão e cinismo) e motivação (i.e. engagement). A hipótese de strain foi corroborada, tanto em termos de efeitos diretos como interativos (hipótese de buffer), sugerindo que a anterior dificuldade em encontrar resultados neste sentido, poderá dever-se ao uso de abordagens centradas nas variáveis. Mais ainda, em termos práticos, estes resultados reforçam que quando existe controlo suficiente no trabalho não é impreterível que se reduzam as exigências uma vez que o controlo sentido irá atenuar os efeitos negativos das mesmas no bem-estar do indivíduo. A hipótese de aprendizagem não pode ser testada uma vez que não surgiu um perfil passivo como se tinha proposto inicialmente. Contudo, as comparações entre os perfis “Active” e “Moderate” sugerem que há maiores níveis de motivação na presença conjunta de altas exigências e alto controlo. Isto leva-nos a crer que trabalhadores com elevadas exigências mas também com alto níveis de controlo sobre o seu trabalho, estarão mais motivados a crescer profissionalmente e, a obter melhores resultados.
Gousseva, Anastasia. "Investigating the Expansion of Angiosperms during the Cretaceous Period using a Modeling Approach." Thesis, 2010. http://hdl.handle.net/1807/25601.
Lin, Ming-Ching, and 林明靜. "Study on anti-lipopolysaccharide factor modulation of LPS-mediated inflammatory response in murine macrophage RAW264.7 cell by microarray approach." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/78458898982082378176.
國立宜蘭大學
生物技術研究所碩士班
97
The shrimp anti-lipopolysaccharide factor peptide (anti-LPS), SALF, has been demonstrated to protect animals against sepsis. Gram-negative bacterial sepsis may be due to the activation of host immune responses by LPS. LPS may go through the MAPK or NFκB pathway to increase the level of the proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL-12, and IL-10, which may damage cells and lead to organ injury. The most important proinflammatory cytokine was TNF-α. RAW264.7 cell was treated with LPS (10 or 100 ng/ml) with different concentrations of SALF (0~100 μg/ml) for 4h, and the cell culture supernatants were screened for TNF-α by ELISA. The observation showed that SALF (20 μg/ml) was able to modulate the inflammatory responses by inhibiting the release of the TNF-α in LPS (100μg/ml)-stimulated mouse macrophage cells (RAW264.7). Treatment of SALF for 2h followed by LPS for 24h in RAW264.7 cells inhibited the TNF-α production around 79.1%. The microarray results showed that some genes had been modulated by two-fold changes. We selected the genes encoding immune-related proteins such as CD36, SCAR, ITGAX, CLU, ACTB, MYC, ANP32A, KLF2, CDC25L, SLPI, KS1, NOD1 and NFκB, which changed two-fold up or down for further analysis. Furthermore, we checked the expression of selected genes by real-time PCR in SALF and LPS treated RAW264.7 cells with the presence of specific inhibitors or activators to confirm the NFκB mediated mechanism. Finally, we found that SALF not only inhibited TNF-α, but also inhibited the cytokine of IL-1β and IL-6.
Teixeira, Santos Ana Carolina. "Working memory and neuroplasticity in older people: a behavioural and neurofunctional approach." Doctoral thesis, 2020. http://hdl.handle.net/1822/76490.
Working memory training (WMT) has been used to promote neuroplasticity in older people and tDCS has been proposed to boost WMT effects. Nevertheless, there is not robust evidence of WMT effectiveness and the few studies assessing the combination of tDCS with WMT used cognitive tasks as endpoints. However, the use of different markers, as the event-related potentials (ERPs), can be useful to better understand the combined or individual effects of these interventions. Thus, the studies presented in this dissertation aimed to assess WMT effects, as well as, the add-on effects of tDCS. Given the need to use different endpoints to measures WMT-induced neuroplasticity, an additional aim was to assess if the ERPs can be used as indexes of fluid intelligence (Gf), a commonly assessed constructed to infer generalization of WMT. In the first study, we presented a meta-analysis on the effects of WMT in healthy elderly. Small significant and long-lasting gains were observed in working memory (WM), but not in short-term memory (STM) and Gf tasks. Type of training tasks, the adopted outcome measures, the training duration, and the total number of training hours moderated WMT effects. In the second study, we performed a systematic review on the uses of tDCS to boost WM in healthy older adults. The studies suggest that tDCS may modulate WM in this population, improving the accuracy and shortening the reaction time. In the third study, we performed a randomized double-blind controlled experiment to evaluate the effects of 5-day WMT coupled with tDCS in healthy older adults. Fifty-four participants were assigned to one of three groups: 1) WMT (dual n-back task)+active tDCS (atDCS); 2) WMT+sham tDCS (stDCS); or 3) sham task + sham tDCS. During the training, both groups that performed the dual n-back task (WMT+atDCS; WMT+stDCS) improved throughout sessions, with no significant differences between them. However, the “WMT+atDCS” was the only group that presented gains in Gf and verbal STM after training (i.e., next day after the intervention) and at follow-up (i.e., 15 days follow-up). Finally, in the fourth study, we explored whether ERP components (i.e., P2, P3b and the LPC - late positive complex) are associated with Gf in the elderly. Fifty-seven participants performed a continuous performance task and a visual oddball paradigm while EEG was recorded. They were divided into high-performance (HP) and low performance (LP) groups according to their performance in the Raven’s Advanced Progressive Matrices test (RAPM). HP group presented significant higher LPC amplitudes in the CPT and shorter P3b latencies in the oddball task when compared to the LP group.
O treino da memória de trabalho (WMT) tem sido usado para promover neuroplasticidade em idosos e a ETCC tem sido adotada para potencializar seus efeitos. No entanto, não há evidências robustas da eficácia do WMT e os poucos estudos que avaliaram a combinação da ETCC com o WMT usaram tarefas cognitivas como medidas. O uso de diferentes marcadores, como os potenciais evocados (ERPs), pode ser útil para entender melhor os efeitos dessas intervenções. Assim, os estudos desta dissertação objetivaram avaliar os efeitos do WMT, bem como, os efeitos adicionais da ETCC. Dada a necessidade de usar diferentes parâmetros para mensurar a neuroplasticidade induzida pelo WMT, um objetivo adicional foi avaliar se os ERPs procedem como índices de inteligência fluida (Gf), um construto comumente avaliado para inferir generalização do WMT. No primeiro estudo, apresentamos uma meta-análise sobre os efeitos do WMT em idosos. Foram observados pequenos e duradouros ganhos na memória de trabalho (WM), mas não na memória a curto prazo (STM) e Gf. O tipo de tarefas treinadas, as medidas adotadas e a duração/número total de horas de treino moderaram os efeitos. No segundo estudo, realizamos uma revisão sistemática sobre o uso de ETCC para melhorar a WM em idosos saudáveis. Os estudos sugerem que a ETCC pode modular a WM nessa população, aumentando a precisão e reduzindo o tempo de reação. No terceiro estudo, foi realizado um experimento aleatório duplo-cego para avaliar os efeitos do WMT associados à ETCC. Cinquenta e quatro idosos foram designados para um de três grupos: 1) WMT (tarefa dual n-back) + ETCC ativa (aETCC); 2) WMT + sham ETCC (sETCC); ou 3) tarefa placebo + sham ETCC. Durante o treino, os dois grupos que realizaram a tarefa dual n-back (WMT+aETCC; WMT+sETCC) melhoram ao longo das sessões, sem diferenças significativas entre eles. No entanto, o "WMT + aETCC" foi o único grupo que apresentou ganhos na Gf e STM após o treino e no seguimento de 15 dias. Por fim, no quarto estudo, exploramos se os componentes dos ERPs (P2, P3b e LPC – late positive complex) estão associados à Gf. Cinquenta e sete idosos realizaram uma tarefa de desempenho contínuo (CPT) e um oddbball visual enquanto o EEG era gravado. Participantes foram divididos em grupos de alto desempenho (HP) e baixo desempenho (LP) de acordo com seu desempenho na Matrizes Progressivas Avançadas de Raven (RAPM). O grupo HP apresentou amplitudes superiores no LPC evocado pela tarefa CPT e latências mais curtas na P3b evocada pela oddball quando comparado com o grupo LP.
Fundação BIAL
Fundação para a Ciência e a Tecnologia (FCT)
Mutale, Oswald Levy. "Climate change mitigation: an analysis of liquefied petroleum gas (LPG) as an alternative domestic energy source to charcoal in Zambia." Diss., 2019. http://hdl.handle.net/10500/25775.
Development Studies
M. A. (Development Studies)
Amaro-Leal, Ângela. "Peripheral multiorgan dysfunction induced by sepsis : the role of NFκB pathway and its impact on brain and heart function." Doctoral thesis, 2018. http://hdl.handle.net/10451/48472.
Srivastava, Shweta. "Stabilization Schemes for Convection Dominated Scalar Problems with Different Time Discretizations in Time dependent Domains." Thesis, 2017. http://etd.iisc.ac.in/handle/2005/3574.
Srivastava, Shweta. "Stabilization Schemes for Convection Dominated Scalar Problems with Different Time Discretizations in Time dependent Domains." Thesis, 2017. http://etd.iisc.ernet.in/2005/3574.