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1
1950-, Kenney Charles, ed. Pursuing the triple aim: Seven innovators show the way to better care, better health, and lower costs. San Francisco: Jossey-Bass, 2012.
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J, Potash Warren, ed. Your lower back: You are not alone : a patient and his doctor answer questions and present exercises to help you manage your lower back. Jenkintown, PA: Paragon, 1993.
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Mason, Peggy. Voluntary Motor Control. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0020.
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The motor hierarchy uses muscle twitches as building blocks for complex and consciously driven actions requiring neocortical involvement. Cortical regions operate in concert with the cerebellum and basal ganglia to generate well-timed and organized muscle contractions that produce movements, ranging from simple to complex. Once imbued with meaning, these movements are considered actions. Adjustments in motor commands are made to accommodate changes in muscle load, maintain an upright posture, and anticipate and avoid errors. Brainstem motor control centers employ circuits in lower parts of the motor hierarchy to produce fairly complex movements, such as ingestion or locomotion. Since the brain adds meaning to movements, two different actions can share the same component movements and serve different end goals. Brain lesions may independently impair movements made under different contexts. For example, patients may be unable to smile volitionally while retaining the ability to smile in response to a joke.
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Burke, David. Motor control: spinal and cortical mechanisms. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199688395.003.0003.
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There is extensive machinery at cerebral and spinal levels to support voluntary movement, but spinal mechanisms are often ignored by clinicians and researchers. For movements of the upper and lower limbs, what the brain commands can be modified or even suppressed completely at spinal level. The corticospinal system is the executive pathway for movement arising largely from primary motor cortex, but movement is not initiated there, and other pathways normally contribute to movement. Greater use of these pathways can allow movement to be restored when the corticospinal system is damaged by, e.g. stroke, but there can be unwanted consequences of this ‘plasticity’. There is an extensive literature on cerebral mechanisms in the control of movement, and an equally large literature on spinal reflex function and the changes that occur during movement, and when pathology results in weakness and/or spasticity.
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Cunningham-Hill, Susan, and Karen Elder. 4. The Nature, Extent, and Recovery of Legal Costs. Oxford University Press, 2018. http://dx.doi.org/10.1093/he/9780198823193.003.0004.
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This chapter focuses on the control and recovery of costs. Topics covered include the discretionary nature of costs awards, the general principle that the loser pays, how the court controls costs incurred, the basis upon which costs orders are made. In addition, the aspects of a legal representative’s work that are recoverable and how they are formulated, as well as the different types of costs order, are explained. This chapter also considers and helps to identify the changes or amendments that may be implemented in the future regarding the amount and recovery of costs in civil litigation.
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Sheehan, Michelle. On the difference between exhaustive and partial control. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198815853.003.0006.
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This chapter compares the partial/exhaustive control distinction in Russian, Icelandic and European Portuguese and argues that all three share a common core: genuine partial control readings are only possible where PRO has case. An analysis of these patterns is outlined whereby partial control involves agreement between a higher thematic head and pro in the edge of a lower CP phase. Although this thematic head Agrees with pro, it is unable to attract it to absorb its θ-role. As a result, a distinct controller is merged with said thematic head and a condition is imposed at the interface that the controller and pro must be non-distinct, yielding partial control. New evidence is presented for this analysis based on negative controllers and the interaction with wh-movement.
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Cunningham-Hill, Susan, and Karen Elder. 4. The nature, extent, and recovery of legal costs. Oxford University Press, 2017. http://dx.doi.org/10.1093/he/9780198787655.003.0004.
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This chapter focuses on the control and recovery of costs including: the discretionary nature of costs awards; the general principle that the loser pays; how the court controls costs incurred; the basis upon which costs orders are made; the aspects of a legal representative’s work that are recoverable and how they are formulated; and the different types of costs order. Lord Jackson’s Review is also considered throughout the chapter to help identify the changes in place since 1 April 2013 regarding the amount and recovery of costs in civil litigation and the extent of the potential amendments that may be implemented in the future.
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Couch, James B. Achieving the Quadruple Aim in a Technology-Driven Transformed Health System: Better Care, Improved Health, Lower Costs and Decreased Medical Liability. Nova Science Publishers, Incorporated, 2015.
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Daly, Donna, and Christopher Chapple. Anatomy, neurophysiology, and pharmacological control mechanisms of the bladder. Edited by Christopher R. Chapple. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0034.
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The lower urinary tract has two main functions; the collection and low pressure storage of urine and periodical controlled elimination of urine at an appropriate time. In order to achieve continence during bladder filling and storage and produce efficient and effective bladder emptying, there is accurate coordination between opening and closing of the urethral sphincters and contraction of the detrusor smooth muscle. The process of micturition has two phases: the storage/filling phase and the voiding phase. The analogy for the transition between these two phases has been described as an on-off circuit, rather akin to flicking a light switch, between synchronous bladder contraction and urethral outlet relaxation, and vice versa. These phases are regulated by a complex, integration of somatic and autonomic efferent and afferent mechanisms that coordinate the activity of the bladder and urethra. This chapter provides an overview of our current understanding of these complex mechanisms.
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Couch, James B. Achieving the Quadruple Aim in a Technology-Driven Transformed Health System: Better Care, Improved Health, Lower Costs and Decreased Medical Liability. Nova Science Publishers, Incorporated, 2014.
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11
Gsell, Beate, and Wolfgang Hau, eds. Rechtsmittel im Zivilprozess - Hommage an Bruno Rimmelspacher. Nomos Verlagsgesellschaft mbH & Co. KG, 2019. http://dx.doi.org/10.5771/9783748900764.
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To what extent is control of the lower courts necessary or even indispensable for the administration of justice, and to what extent is such control rather inappropriate and ultimately self-defeating? These are key questions in procedural law in general, but in particular in civil and commercial cases. The contributions collected in this volume deal with this topic from both a German and a French perspective, paying tribute to Professor Bruno Rimmelspacher, a leading expert in the law of appellate proceedings, on the occasion of his 80th birthday. With contributions by Frédérique Ferrand, Herbert Roth, Ulrich Spellenberg and Thomas Winter.
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Panicker, Jalesh N., and Clare J. Fowler. Non-traumatic neurourology. Edited by Christopher R. Chapple. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0046.
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This chapter reviews bladder disturbances in non-traumatic neurological conditions and provides an approach to its evaluation and management. The pattern of bladder dysfunction depends upon the level of neurological localisation and accordingly, lesions can be suprapontine, infrapontine/suprasacral (spinal), or infrasacral. The importance of the frontal lobes for bladder control has been confirmed and vascular disease or tumour can result in incontinence. There is better understanding about the very different urological profile of the two sometimes confused conditions, multiple system atrophy and Parkinson’s disease. Guidelines for the management of lower urinary tract dysfunction in multiple sclerosis are reviewed. Lower urinary tract (LUT) dysfunction is common in neurological disease and its importance to patient health and quality of life is now widely recognized.
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Adelstein, Richard. The Exchange Order. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190694272.001.0001.
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This book illuminates a comprehensive social system that comprises explicit markets, tort liability, and criminal liability, and describes each of these three institutions as serving the same function in different social and physical circumstances. It defines exchanges as compensated transfers of rights and objects among individuals, and shows that markets, tort, and crime each operate to organize and facilitate, to govern, exchange of a particular kind of right in a particular exchange environment to which its own rules and procedures are well suited. Under perfect conditions, each operates to move rights and objects from lower- to higher-valuing owners by requiring every taker of rights to compensate every loser in full for the costs of the taking. Markets can organize voluntary exchange of property rights only where theft can be deterred, but when rights or objects are stolen, an involuntary transfer is initiated, and markets are incapable of organizing the completion of the involuntary exchange by compensating the victim. This is the role of tort and criminal liability, which complete the involuntary transaction begun by the theft by imposing a compensatory liability price on every offender equal to the costs imposed by the theft. Marginal-cost pricing in markets controls voluntary, lawful cost imposition by distinguishing inefficient from efficient cost imposition and encouraging the latter, and corrective justice in tort and crime, each in an institutional domain determined by the character of the rights being traded, controls involuntary, unlawful cost imposition in the same way.
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Kirchman, David L. Microbial growth, biomass production, and controls. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789406.003.0008.
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Soon after the discovery that bacteria are abundant in natural environments, the question arose as to whether or not they were active. Although the plate count method suggested that they were dormant if not dead, other methods indicated that a large fraction of bacteria and fungi are active, as discussed in this chapter. It goes on to discuss fundamental equations for exponential growth and logistic growth, and it describes phases of growth in batch cultures, continuous cultures, and chemostats. In contrast with measuring growth in laboratory cultures, it is difficult to measure in natural environments for complex communities with co-occurring mortality. Among many methods that have been suggested over the years, the most common one for bacteria is the leucine approach, while for fungi it is the acetate-in ergosterol method. These methods indicate that the growth rate of the bulk community is on the order of days for bacteria in their natural environment. It is faster in aquatic habitats than in soils, and bacteria grow faster than fungi in soils. But bulk rates for bacteria appear to be slower than those for phytoplankton. All of these rates for natural communities are much slower than rates measured for most microbes in the laboratory. Rates in subsurface environments hundreds of meters from light-driven primary production and high organic carbon conditions are even lower. Rates vary greatly among microbial taxa, according to data on 16S rRNA. Copiotrophic bacteria grow much faster than oligotrophic bacteria, but may have low growth rates when conditions turn unfavorable. Some of the factors limiting heterotrophic bacteria and fungi include temperature and inorganic nutrients, but the supply of organic compounds is perhaps most important in most environments.
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Isett, Philip. The Coarse Scale Flow and Commutator Estimates. Princeton University Press, 2017. http://dx.doi.org/10.23943/princeton/9780691174822.003.0016.
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This chapter derives estimates for the coarse scale flow and commutator. Instead of mollifying the velocity field in the time variable, it derives a Transport equation for vsubscript Element and some estimates that will be necessary for the proof. Here the quadratic term arises from the failure of the nonlinearity to commute with the averaging. Commutator estimates are then derived. To observe cancellation in the quadratic term, the control over the higher-frequency part of v is used, and cancellation is obtained from the lower-frequency parts. It becomes clear that the commutator terms can be estimated using the control of only the derivatives of v. The chapter concludes by presenting the theorem for coarse scale flow estimates.
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Donovan, John E. A Framework for Studying Parental Socialization of Child and Adolescent Substance Use. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190676001.003.0010.
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This chapter presents a model of parental socialization that summarizes the interrelations among parental modeling of substance use, parent approval, parental monitoring and control, parent–child relationship quality, child cognitions, friends’ substance use, and child/adolescent substance use. Parental alcohol consumption, smoking, and drug use are significant predictors of child and adolescent drinking, smoking, and marijuana use. Parental substance use is associated with lower quality parenting and family management practices and lower quality relationships with offspring, both of which are associated with greater offspring substance use. Parental substance use, parental approval, parenting practices, and relationship quality are associated with adolescents’ affiliation with substance-using friends. Parental non-use, effective parenting practices, and good-quality parent–child relationships buffer the relation between friends’ modeling of substance use and adolescent offspring substance use. The model should facilitate the development of targeted tests of its utility for generating new research on the socialization of adolescent substance use.
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Harris-Adamson, Carisa, Stephen S. Bao, and Bradley Evanoff. Musculoskeletal Disorders. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190662677.003.0023.
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This chapter describes the nature and magnitude of work-related musculoskeletal disorders (WRMSDs) and their prevention and control. The incidence and severity of musculoskeletal disorders is described by body region and by occupation, and a conceptual model for the contributors and pathways to developing WRMSDs is described. Neck disorders and upper-extremity disorders as well as low back pain and lower-extremity disorders are described in detail, including evaluation, diagnosis, and prevention. Personal factors, physical exposures, and psychosocial stress that contribute to the development of WRMSDs are described. Ergonomic interventions to reduce or eliminate physical exposures are stressed as critically important preventive measures.
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Swanson, Diane L. Top Managers as Drivers for Corporate Social Responsibility. Edited by Andrew Crane, Dirk Matten, Abagail McWilliams, Jeremy Moon, and Donald S. Siegel. Oxford University Press, 2009. http://dx.doi.org/10.1093/oxfordhb/9780199211593.003.0010.
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This article addresses top managers as drivers for corporate social responsibility (CSR). It summarizes the responsibility roles implied by or assigned to managers in selected models of corporate social performance. Given this backdrop for business and society research, it focuses on the importance of moral leadership in directing the formal and informal organization toward socially responsible goals. In other words, the emphasis is on the focal role of top executive managers in driving social responsibility. This focus is not meant to convey that middle or lower managers are irrelevant to CSR. It is simply that their decision-making discretion is largely circumscribed by top managers, which is why middle and lower managers often face uncomfortable moral dilemmas when their values are incompatible with those established at a higher level of command. Finally, this article points to some contextual factors that impact socially responsible leadership in terms of external and internal controls.
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Guillery, Ray. Thalamic higher-order driver inputs as sensorimotor links. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198806738.003.0009.
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This chapter provides a closer look at the branching patterns of driver inputs to higher-order thalamic nuclei, and introduces their functional significance for discussion in later chapters. Their thalamic branches bring information for relay to higher cortical levels, including a copy of the information carried in the motor branches about anticipated cortical contributions to the control of actions and consequent changes in perceptions. In this way, the cortex can add to the control of an action when there is a mismatch between action and perception. Most of these branched axons that have so far been described come from early sensory areas and only a few from other, higher areas have been studied. These branching inputs are a part of the hierarchy of cortical areas that provide an opportunity for higher areas to monitor lower areas and, when needed, contribute to the motor control of the phylogenetically older brainstem and spinal centres. A far more extensive review of the branched thalamic driver inputs and their contributions to the control of actions than we have at present will be crucial for understanding the full complexity of the thalamic relay.
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Oshiro, Thomas, and Lawrence W. Bassett. An Overview of Digital Mammography Technology and MQSA Requirements. Edited by Christoph I. Lee, Constance D. Lehman, and Lawrence W. Bassett. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190270261.003.0006.
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Understanding the fundamentals of mammographic imaging is essential for any practicing physician. The elements described in this section should serve as a brief review of how digital mammography systems acquire and generate images. Equipment including digital receptor design and technical factors to optimize the radiographic contrast and spatial resolution while reducing breast doses to lower levels are outlined. General image processing features as well as commonly encountered clinical artifacts will be reviewed. MQSA (Mammography Quality Standards Act) and ACR standards that define qualifications for personnel (interpreting physicians, radiologic technologists and medical physicists), minimum equipment performance characteristics and methodologies for routine quality control testing are summarized.
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Kearney, Christopher A., and Anne Marie Albano. When Children Refuse School. Oxford University Press, 2018. http://dx.doi.org/10.1093/med-psych/9780190604059.001.0001.
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Problematic school absenteeism is the primary focus of When Children Refuse School: A Cognitive-Behavioral Therapy Approach, Therapist Guide. Youths who complete high school are more likely to experience greater success at social, academic, occupational, and economic aspects of functioning than youths who do not. Youths with problematic school absenteeism are at risk for lower academic performance and achievement, lower reading and mathematics test scores, fewer literacy skills, internalizing and externalizing behavior problems, grade retention, involvement with the juvenile justice system, and dropout. The treatment program presented here is designed for youths with primary and acute school refusal behavior. The program is based on a functional model of school refusal behavior that classifies youths on the basis of what reinforces absenteeism. For children who refuse school to avoid school-based stimuli that provoke negative affectivity, the treatment uses child-based psychoeducation, somatic control exercises, gradual reintroduction (exposure) to the regular classroom setting, and self-reinforcement. For children who refuse school to escape aversive social and/or evaluative situations, the treatment uses child-based psychoeducation, somatic control exercises, cognitive restructuring, gradual reintroduction (exposure) to the regular classroom setting, and self-reinforcement. For youths who refuse school to pursue attention from significant others, parent-based treatment includes modifying parent commands, establishing regular daily routines, developing rewards, reducing excessive reassurance-seeking behavior, and engaging in forced school attendance. For youths who refuse school to pursue tangible rewards outside of school, family-based treatment includes contingency contracts, communication skills, escorting the child to school and from class to class, and peer refusal skills.
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Weaver, Virginia M., Bernard G. Jaar, and Jeffrey J. Fadrowski. Kidney Disorders. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190662677.003.0031.
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This chapter describes kidney disorders related to occupational and environmental exposures and addresses prevention and control. Sections address assessment of kidney function, acute kidney injury, and chronic kidney disease (CKD). Kidney disease from acute, high-level exposures as well as lower level exposures in combination with other CKD risk factors are considered. Established nephrotoxicants, including aristolochic acid, arsenic, cadmium, lead, melamine, mercury, silica, and solvents, are discussed. The limited data available on other agents, such as perfluorooctanoic acid and fine particulate matter, are also presented. The potential for kidney function to impact biomarker levels is considered. A final section addresses a current epidemic of CKD of unknown etiology in agricultural workers in specific countries.
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Shaw, Pamela. The motor neurone disorders. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569381.003.0524.
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The motor neurone diseases are a group of disorders in which there is selective loss of function of upper and/or lower motor neurones in the motor cortex, brainstem, and spinal cord resulting in impairment in the nervous system control of voluntary movement. The term ‘motor neurone disease’, often abbreviated to ‘MND’, is used differently in different countries. In the United Kingdom it is used as an umbrella term to cover the related group of neurodegenerative disorders including amyotrophic lateral sclerosis, the commonest variant, as well as progressive muscular atrophy, primary lateral sclerosis, and progressive bulbar palsy. However, in many other countries amyotrophic lateral sclerosis, referred to as ALS, has been adopted as the umbrella term for this group of clinical variants of motor system degeneration. There is a tendency now internationally to use the ALS/MND abbreviation to cover this group of conditions. Careful diagnosis within the motor neurone diseases is essential for advising about prognosis, potential genetic implications, and for identifying those with acquired lower motor neurone syndromes who may benefit for the administration of immunomodulatory therapy.
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Mishra, Ajit. The Many Faces of Corruption. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198812555.003.0020.
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As is well known, corruption has several faces, ranging from petty corruption, where ordinary citizens have to pay bribes to get goods and services, to high level political corruption. Anti-corruption policies have to take cognizance of the possible trade-offs existing between different forms of corruption such as collusion, extortion, embezzlement, and bribery. Efforts to control one form may encourage another. In such a context, the chapter argues that, despite its lower value and gift-like manifestation, extortive petty corruption is not to be ignored as it creates a ‘culture’ of corruption which contributes to its persistence. This form of corruption spreads easily as victims of bribery are more likely to seek bribes when they are given the chance to do so.
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Kastler, Bruno, and Adrian Kastler. Lumbar Sympathetic Block and Neurolysis: Computed Tomography. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199908004.003.0031.
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Lumbar sympathetic block and neurolysis are accepted treatment procedures in patients with sympathetic mediated lower limb pain and patients with advanced peripheral arterial disease. The use of imaging guidance is highly recommended in order to achieve best possible results and to avoid complications. The high image resolution (as opposed to fluoroscopy) and high availability (as opposed to MRI) offered by CT makes it the imaging guidance technique preferred. This chapter reviews the indications of lumbar sympathetic chain blockade and neurolysis and the basic anatomical background. Then it demonstrates how CT guidance allows a step-by-step control of positioning the needle tip at the target for either lumbar blockade or alcohol neurolysis and the advantages and disadvantages of each technique are summarized.
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Eriksson, Olle, Anders Bergman, Lars Bergqvist, and Johan Hellsvik. Ultrafast Switching Dynamics. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198788669.003.0011.
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The time-integrated amount of data and stored information, is doubled roughly every eighteen months, and since the majority of the worlds information is stored in magnetic media, the possibility to write and retrieve information in a magnetic material at ever greater speed and with lower energy consumption, has obvious benefits for our society. Hence the seemingly simple switching of a magnetic unit, a bit, is a crucial process which defines how efficiently information can be stored and retrieved from a magnetic memory. Of particular interest here are the concepts of ultrafast magnetism and all-optical control of magnetism which have in recent decades become the basis for an intense research field. The motivation is natural; the mechanisms behind these phenomena are far from trivial and the technological implications are huge.
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Neumann, Peter J., Joshua T. Cohen, and Daniel A. Ollendorf. The Right Price. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780197512883.001.0001.
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New medications can provide substantial benefits, but high prescription drug prices have led to calls to contain costs. Even after accounting for discounts and rebates, average prices of leading brand-name drugs in the United States are two to four times higher than in other wealthy countries, raising questions about what these higher prices are buying us. With the advent of ever more targeted and powerful treatments, including cell- and gene-based therapies with multimillion dollar price tags, the need for sensible drug pricing policies will intensify. Price controls, common in other countries, seem appealing, but these measures can discourage innovation. Moreover, on what basis should policymakers develop such controls? This book argues that pricing prescription drugs to reflect the value they bring to patients, families, and society achieves the right balance. The book reviews the distinguishing features of the prescription drug market and explains why simple solutions like price controls and importing drugs from countries with lower drug prices are problematic without explicit assessments of value. It then describes how economists measure value, how value assessment for drugs is now being used in the United States, and what must happen going forward to overcome challenges.
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Barnes, Rosemary A., and Matthijs Backx. Fungal infections in intensive therapy units. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0036.
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Invasive candidiasis remains the main cause of invasive fungal disease in the intensive care unit. The risk of infection is often overestimated and most units will have incidences of 1–2% or lower. Units with higher incidences may have specific geographical and epidemiological factors, or may need to address infection control issues contributing to transmission. Routine use of prophylaxis or empiric therapy is not warranted at this level of disease. Discriminatory risk factors for this low incidence of disease are poorly defined and Candida specific biomarkers have not been validated for pre-emptive therapy. Insights into human response to invasive fungal disease gained from proteomic and genomic studies will increase our understanding, enabling us to target fungal diagnostics and antifungal treatments more accurately.
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Craig, Paul, and Gráinne de Búrca. 27. Competition Law:. Oxford University Press, 2015. http://dx.doi.org/10.1093/he/9780198714927.003.0027.
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All books in this flagship series contain carefully selected substantial extracts from key cases, legislation, and academic debate, providing able students with a stand-alone resource. This chapter focuses on another principal provision concerned with competition policy: Article 102 TFEU. The essence of Article 102 is the control of market power, whether by a single firm or, subject to certain conditions, a number of firms. Monopoly power can lead to higher prices and lower output than would prevail under more normal competitive conditions, and this is the core rationale for legal regulation in this area. Article 102 does not, however, prohibit market power per se. It proscribes the abuse of market power. Firms are encouraged to compete, with the most efficient players being successful.
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Guillery, Ray. The Brain as a Tool. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198806738.001.0001.
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We don’t perceive the world and then react to it. We learn to know it from our interactions with it. All inputs that reach the cerebral cortex about events in the brain, the body, or the world bring two messages: one is about these events, the other, travelling along a branch of that input, is an instruction already on its way to execution. This second message, not a part of standard textbook teaching, allows us to anticipate our actions, distinguishing them from the actions of others, and thus providing a clear sense of self. The mammalian brain has a hierarchy of cortical areas, where higher areas monitor actions of lower areas, and each area can modify actions to be executed by the phylogenetically older brain parts. Brains of our premammalian ancestors lacked this hierarchy, but their descendants are still strikingly capable of movement control: frogs can catch flies. The cortical hierarchy itself appears to establish and increase, from lower to higher levels, our conscious access to events. This book explores the neural connections that provide us with a sense of self and generate our conscious experiences. It reveals how much yet needs to be learnt about the relevant neural pathways.
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Moodie, Deonnie. Resisting Middle-Class Modernizing Projects. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190885267.003.0005.
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Middle-class modernizers frame their projects at Kālīghāṭ as being in the best interests of the Hindu public in Kolkata. However, so many who frequently worship at the temple or who live and work on temple grounds do not share the desire to transform the temple so that it represents Indian modernity. Lower-class men and women are successful in resisting modernizing projects because they employ tactics that make state control difficult or impossible. These include protests, the formation of political organizations, as well as obstinacy and deception. This chapter demonstrates that while middle-class actors may use the tools of civil society to gain state support for their projects, they are not guaranteed success. Even informal and non-legal tools of what Partha Chatterjee calls “political society” are effective in blocking the enactment of modernizing projects.
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Ness, Immanuel. Who Can Organize? Trade Unions, Worker Insurgency, Labor Power. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252036279.003.0007.
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This chapter investigates the policy and practice of established U.S. labor unions toward migrant labor and guest workers and provides alternative models for building worker power on a global basis. Organized labor operates at a disadvantage as it typically responds rather than acts as capital changes the nature of work to lower wages. Ideally, a proactive labor movement would shape the nature of work. Therefore, U.S. national labor unions and peak organizations have historically opposed all forms of migration. Most notably, in 1986, national unions were instrumental in shaping the employer-sanction provision in the 1986 Immigration Reform and Control Act (IRCA). However, because legal penalties for hiring undocumented workers are minimal, the law has not deterred employers from hiring them. Furthermore, because minimum wage and hour standards are often unenforced by state and federal government regulatory agencies, undocumented immigrants are frequently more desirable to employers than U.S.-born workers.
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Carnes, Nicholas. The Cash Ceiling. Princeton University Press, 2018. http://dx.doi.org/10.23943/princeton/9780691182001.001.0001.
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Why are Americans governed by the rich? Millionaires make up only three percent of the public but control all three branches of the federal government. How did this happen? What stops lower-income and working-class Americans from becoming politicians? This book is a compelling and comprehensive account of why so few working-class people hold office—and what reformers can do about it. It debunks popular misconceptions (like the idea that workers are unelectable or unqualified to govern), identifies the factors that keep lower-class Americans off the ballot and out of political institutions, and evaluates a variety of reform proposals. The book shows that in the United States elections have a built-in “cash ceiling,” a series of structural barriers that make it almost impossible for the working-class to run for public office. Elections take a serious toll on candidates, many working-class Americans simply cannot shoulder the practical burdens, and civic and political leaders often pass them over in favor of white-collar candidates. But these obstacles are not inevitable. Pilot programs to recruit, train, and support working-class candidates have the potential to increase the economic diversity of our governing institutions and ultimately amplify the voices of ordinary citizens. Who runs for office goes to the heart of whether the USA has a democracy that is representative or not. The book shows that the best hope for combating the oversized political influence of the rich might simply be to help more working-class Americans become politicians.
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Eder, Lihi. The clinical course and outcome of psoriatic arthritis. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198737582.003.0021.
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In contrast to early reports, it is now appreciated that psoriatic arthritis (PsA) can present as a destructive, progressive, and disabling arthritis with consequences as severe as those of rheumatoid arthritis. Longitudinal cohort studies of PsA patients contributed important knowledge about long-term outcomes, such as development of structural joint damage, remission achievement, and physical function. These studies identified predictors for improved outcomes including male gender and lower burden of inflammation at presentation while delayed diagnosis, disability, and joint damage are associated with worse long-term outcomes. These findings suggest early diagnosis and aggressive control of inflammation are important as they may prevent the occurrence of subsequent joint damage. The latter is strongly correlated with long-term outcomes, such as reduced physical function and increased mortality. Development of prediction models using clinical measures, laboratory biomarkers, and imaging is warranted to stratify patients with early disease into risk groups for long-term outcomes.
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Rascher, Wolfgang. Treatment of hypertension in children. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0219_update_001.
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Management of hypertension is dependent on the underlying cause and the magnitude of the blood pressure abnormality. Healthy behavioural changes are the primary management tool for treating primary hypertension in adolescents and other cardiovascular risk factors and obesity. In children and adolescents with renal hypertension, high blood pressure requires pharmacological treatment. There is randomized controlled trial evidence to support a blood pressure target for those with proteinuria of not higher than the 50th centile for age. The use of angiotensin-converting enzyme inhibitors is safe in patients with proteinuria, and assumed to be equally beneficial. For those without proteinuria, less stringent targets may be acceptable. Often a combination of two or three drugs is required to lower arterial blood pressure to the target blood pressures. In children and adolescents at or near end-stage renal failure, fluid removal by dialysis may be necessary to control hypertension.
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Smith, David M. Evaluating Hedge Fund Performance. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190607371.003.0023.
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A diverse set of measures allow investors to evaluate hedge fund portfolio managers’ performance across different dimensions. The various measures quantify the effectiveness of security selection; account for investor flows, operating risk, and worst-case investment scenarios; net out benchmark and peer-fund performance; and control for risk factors that are unique to hedge fund investment strategies. Hedge fund return information in published databases is usually self-reported, which is a conflict of interest that produces several reporting biases and inflated published average returns. After adjusting for these biases, hedge fund average returns trail equity market returns and in fact almost exactly equal U.S. Treasury bill average returns between January 1994 and March 2016. Yet, after risk adjustment, the hedge fund performance picture brightens. In the aggregate, hedge funds have higher Sharpe ratios and multifactor alphas, and lower maximum drawdown levels than equity market benchmarks.
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Kashyap, Sangeeta. Medical Management of Endocrine Disorders after Bariatric Surgery. Edited by Tomasz Rogula, Philip Schauer, and Tammy Fouse. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190608347.003.0015.
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Endocrine complications after bariatric surgery include persistent hyperglycemia in patients with type 2 diabetes who experience initial success with weight loss. This complication occurs in those with a prolonged duration of diabetes (> 8 years) and is related to poor residual pancreatic beta-cell function. Often, weight regain is associated with recurrent diabetes, and strategies that target both weight loss and glycemic control are required. New diabetes agents, such as the SGLT2 inhibitor drug class, offer advantages to diabetes treatment after bariatric surgery. On the other end of the glycemic spectrum, hyperinsulinemic hypoglycemia occurs in patients with and without diabetes prior to surgery and often presents with little or no symptoms (i.e., neuroglycopenia). Treatment strategies involve careful monitoring of blood glucose levels and the use of low-glycemic/high-fiber diets as well as drugs that lower glucose absorption and insulin secretion. Glycemic management after bariatric surgery requires close observation.
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Falk, Bareket, and Raffy Dotan. Temperature regulation. Edited by Neil Armstrong and Willem van Mechelen. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198757672.003.0014.
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Under all but the most extreme environmental heat conditions, children control their body temperature (at rest and during exercise) as well as adults. Children, however, use a different thermoregulatory strategy. Compared with adults, children rely more on dry heat dissipation and less on evaporative cooling (sweating). Their larger skin surface-area relative to mass does put children at increasing disadvantage, relative to adults, as ambient temperatures rise above skin temperature. Similarly, they become increasingly disadvantaged upon exposure to decreasing temperatures below the thermo-neutral zone. Like adults, children inadvertently dehydrate while exercising in hot conditions and are often hypohydrated, even before exercise, and their core temperature rises considerably more than adults in response to a given fluid (sweat) loss, which may put them at higher risk for heat-related injury. However, epidemiological data show rates of both heat- and cold-related injuries among children and adolescents as similar or lower than at any other age.
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Haas, Jacqui Greene. Dance Anatomy. 2nd ed. Human Kinetics, 2018. http://dx.doi.org/10.5040/9781718212800.
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Experience the raw energy and aesthetic beauty of dance as you perfect your technique with Dance Anatomy. Featuring hundreds of full-color illustrations, Dance Anatomy presents more than 100 of the most effective dance, movement, and performance exercises, each designed to promote correct alignment, improved placement, proper breathing, and prevention of common injuries. The exercises are drawn in stunning detail, capturing the dancer in motion and highlighting the active muscles associated with each movement so you can develop and strengthen different areas of the body. You will clearly see how muscular development translates into greater poise and elegance on the stage. Each chapter addresses a key principle of movement to help you improve performance, beginning with the center of the body, where dance begins. You will learn exercises to target specific areas, such as shoulders and arms, pelvis, and lower legs to enhance flexibility and ensure safety. You will also discover more efficient ways of improving your lines and technique by implementing a supplementary conditioning program that takes into account your changing cycles of classes, practices, and times of rest. Regardless of your ability level or dance style, Dance Anatomy will help you master the impeccable balance, intense muscular control, and grace to prepare you for your next leading role!
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O'Brien, Carl Séan, and John Dillon, eds. Platonic Love from Antiquity to the Renaissance. Cambridge University Press, 2022. http://dx.doi.org/10.1017/9781108525596.
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Platonic love is a concept that has profoundly shaped Western literature, philosophy and intellectual history for centuries. First developed in the Symposium and the Phaedrus, it was taken up by subsequent thinkers in antiquity, entered the theological debates of the Middle Ages, and played a key role in the reception of Neoplatonism and the etiquette of romantic relationships during the Italian Renaissance. In this wide-ranging reference work, a leading team of international specialists examines the Platonic distinction between higher and lower forms of eros, the role of the higher form in the ascent of the soul and the concept of Beauty. They also treat the possibilities for friendship and interpersonal love in a Platonic framework, as well as the relationship between love, rhetoric and wisdom. Subsequent developments are explored in Plutarch, Plotinus, Augustine, Pseudo-Dionysius, Eriugena, Aquinas, Ficino, della Mirandola, Castiglione and the contra amorem tradition.
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Rello, Jordi, and Bárbara Borgatta. Pathophysiology of pneumonia. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0115.
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Airway colonization, ventilator-associated tracheobronchitis (VAT), and hospital-acquired (HAP) and ventilator-associated pneumonia (VAP) are three manifestations having the presence of micro-organisms in airways in common. Newer definitions have to consider worsening of oxygenation, in addition to purulent respiratory secretions, chest-X rays opacities, and biomarkers of inflammation. Bacteria are the main causes of HAP/VAP. During hospitalization there’s a shift of airway’s colonizing flora from core organisms to enteric and non-fermentative ones. Macro- and micro-aspiration is the most important source of pneumonia. Endotracheal tube secretion leakage is an important source, serving biofilm as a reservoir. Exogenous colonization is infrequent, but it may contribute to cross-infection with resistant species. Prevention of VAP can be achieved by implementing multidisciplinary care bundles focusing on oral/hand hygiene and control of sedation. Pneumonia develops when micro-organisms overwhelm host defences, resulting in a multifocal process. Risk and severity of pneumonia is determined by bacterial burden, organism virulence and host defences. Innate and adaptive immune responses are altered, decreasing clearing of pathogens. Some deficits of the complement pathway in intubated patients are associated with increased risk for VAP and higher mortality. Micro-arrays have demonstrated specific different immunological signatures for VAP and VAT. Early antibiotic therapy is associated with a decrease in early HAP/VAP incidence, but selects for MDR organisms. Attributable mortality is lower than 10%, but HAP/VAP prolongs length of stay, and dramatically increase costs and use of health care resources.
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Financial management: DOD needs to lower the disbursement prevalidation threshold : report to congressional requesters. Washington, D.C: The Office, 1996.
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Barclay, Katie. Caritas. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780198868132.001.0001.
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Caritas, a form of divine grace that transformed neighbourly love into moral action, was a key concept in early modern Europe, guiding ideas about morality, the self, and becoming an embodied ethic. This book introduces the concept of an ‘emotional ethic’ to help explain the role of caritas in early modern communities, where love was not simply how one should feel about one’s neighbour but the ways that our bodies and emotions guide us to ethical action. It explores how an emotional ethic operates through a study of how caritas was deployed amongst the lower orders in eighteenth-century Scotland. With chapters that focus on marriage, childhood and youth, ‘sinful sex’, privacy and secrecy, and hospitality towards the itinerant poor, the ways in which caritas was learned and deployed as part of everyday social practice are highlighted. Caritas enjoined Christians to modesty, chastity, control of dress, and passion, but also to a generous love and care, imagined in familial terms. As an ethic that was enacted through the body, caritas produced a particular form of sociable self. Over the eighteenth century, new ideas of romantic love, as well as more secular social emotions like fraternity and benevolence, offered alternative mechanisms for justifying feeling and behaviour. This book explores how new ideas about emotion intertwined with an older model of neighbourly love, explaining not only deviant behaviours but also how the self came to be formed in this new context.
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Jha, Vivekanand. Acute kidney injury in the tropics. Edited by Norbert Lameire. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0241.
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The spectrum of acute kidney injury (AKI) encountered in the hospitals of the tropical zone countries is different from that seen in the non-tropical climate countries, most of which are high-income countries. The difference is explained in large part by the influence of environment on the epidemiology of human disease. The key features of geographic regions falling in the tropical zones are climatic, that is, high temperatures and absence of winter frost, and economic, that is, lower levels of income. The causes and presentation of tropical AKI reflect these prevailing cultural, socioeconomic, climatic, and eco-biological characteristics.Peculiarities of tropical climate support the propagation of several infectious organisms that can cause AKI and the disease-transmitting vectors. In contrast to the developed world, where AKI usually develops in already hospitalized patients with multiorgan problems and iatrogenic factors play a major role, tropical AKI is acquired in the community due to issues of public health importance such as safe water, sanitation, infection control, and good obstetric practices. Infections such as malaria, leptospirosis, typhus, HIV, and diarrhoeal diseases; envenomation by animals or insects; ingestion of toxic herbs or chemicals; intravascular haemolysis; poisoning; and obstetric complications form the bulk of AKI in the tropics. Poor access to modern medical facilities and practices such as seeking treatment from traditional faith-healers contribute to poor outcomes.AKI extracts macro- and microeconomic costs from the affected population and reduces productivity. Improvement in the outcomes of tropical AKI requires improvement in basic public health through effective interventions, and accessibility to effective medical care.
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Jayne, David. Treatment of ANCA-associated vasculitis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0132.
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The goals of treatment in anti-neutrophil cytoplasm antibody (ANCA) vasculitis are to stop vasculitic activity, to prevent vasculitis returning, and to address longer-term comorbidities caused by tissue damage, drug toxicity, and increased cardiovascular and malignancy risk. Cyclophosphamide and high-dose glucocorticoids remain the standard induction therapy with alternative immunosuppressives, such as methotrexate or azathioprine, to prevent relapse. Refractory disease resulting from a failure of induction or remission maintenance therapy requires alternative agents and rituximab has been particularly effective. Replacement of cyclophosphamide by rituximab for remission induction is supported by recent evidence. Additional therapy with intravenous methylprednisolone and plasma exchange is employed in severe presentations with failing vital organ function. Drug toxicity contributes to comorbidity and mortality and has led to newer regimens with reduced cyclophosphamide exposure. Glucocorticoid toxicity remains a major problem, with controversy over the rapidity with which glucocorticoids can be reduced or withdrawn. Disease relapse occurs in 50% and requires early detection at a stage when it will not adversely affect outcomes. Rates of cardiovascular disease and malignancy are higher than in control populations but strategies to reduce their risk, apart from cyclophosphamide-sparing regimens, have not been developed. Thromboembolic events occur in 10% and may be linked to the recently identified autoantibodies to plasminogen and tissue plasminogen activator. Outcomes of vasculitis depend heavily on the level of tissue damage at diagnosis, especially renal dysfunction, but are also influenced by patient age, ANCA subtype, disease extent, and response to therapy. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)is treated along similar principles to granulomatosis with polyangiitis (GPA) and microscopic polyangiitis but the persistence of steroid-dependent asthma in over one-third and differences in pathogenesis has suggested alternative treatment approaches. Chronic morbidity results from tissue damage and is especially common in the upper and lower respiratory tract and kidneys. Tracheobronchial disease is a severe late complication of GPA, while deafness, nasal obstruction, and chronic sinusitis are sequelae of nasal and ear vasculitis. Chronic infection of damaged epithelial surfaces acts as a drive for vasculitic activity and adequate infection control is necessary for stable remission. Chronic kidney disease can stabilize for many years but the risks of endstage renal disease (ESRD) are increased by acute kidney injury at presentation or renal relapse. Renal transplantation is successful, with similar outcomes to other causes of ESRD.
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Inglis, Patrick. Narrow Fairways. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190664763.001.0001.
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Despite India’s three decades of economic liberalization, access to quality education, well-paying jobs, and high standards of living align with prior class and caste advantages, leaving many poor and working-class people stuck in place and obligated to seek handouts from the rich. The study draws on ten years of ethnographic fieldwork at three private golf clubs in Bangalore, India’s Silicon Valley, to explore the ties of dependence wealthy club members generate with the poor lower-caste golf caddies who carry their bags, and in a manner that reproduces their positions of privilege and authority. The caddies are not employees, and yet neither do they have complete control over their rates and schedules. Making $3–5 for a five- or six-hour round, caddies deploy acts servility and deference to yield additional money for healthcare, children’s school fees, and other household expenses. While a rare few caddies win sufficient support to put them and their families on a path of social mobility, most struggle to make ends meet, living in less-than-secure housing, going without food in some cases, and sending their children to low-quality schools that all but guarantee they will take up similar work as their fathers. The necessity but ultimate limitation of such relationships between the rich and poor underscores the failure of India’s development strategy, which favors private over public interests, and has yet to establish well-funded healthcare, education, and basic social services that would improve chances of social mobility and independence among the poor.
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Márquez-Peláez, Sergio, Juan Antonio Blasco-Amaro, and Mª José Aguado-Romeo. Incompatible living-donor kidney transplantation (an update). AETSA Área de Evaluación de Tecnologías Sanitarias de Andalucía, Fundación Progreso y salud. Consejería de Salud y Familias. Junta de Andalucía, 2022. http://dx.doi.org/10.52766/kpnf6027.
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Background This report responds to a need to update the available information about incompatible living-donor kidney transplantation (LDKT) previously published in 2014 which, based on 14 case series and 1 cohort study, concluded that this type of transplants could be a therapeutic option with survival, graft and patient outcomes, adequate and similar to a compatible living-donor kidney transplant, however, these report only included ABO-incompatible information. Objective The purpose of the report is to provide updated evidence on effectiveness and safety in terms of graft survival and survival of patients undergoing incompatible LDKT. Method To answer the question a systematic review of the literature was carried out, by updating the structured searches of the previous existing report. The selection of the references was carried out first by title and abstract. Next, the full-text papers were selected by applying the inclusion and exclusion criteria, defined a priori, by a single researcher. In the same way, we proceeded to extract the data from the articles finally selected, and their synthesis in tables similar to those of the previous report, with special attention to the HLA incompatibility LDKT data, since no information was collected in the previous report. Results From 232 localized references, 35 papers on incompatible LDKT have finally been included, 16 with information on HLAi transplant patients and 19 with ABO incompatible transplant patients. In all cases, case series with or without a control group and a very limited number of patients were treated, only 1 study registered more than 1000 patients undergoing incompatible LDKT in 22 centers (Orandi et al. 2014) in the case of HLAi. The information on graft survival in patients undergoing HLA-incompatible LDKT at 1 year is between 90 % (Laftavi et al. 2011) and 100 % (Blumberg et al. 2013; Yamanaga et al. 2013), while the data recorded over five years survival were lower, from 69 % (Couzi et al. 2015) to 94.7 % (Jakson et al. 2015). The 1-year patient survival registered was found between 90.5 % by Sharif et al. 2014 and 100 % (Blumberg et al. 2013 and Laftavi et al. 2011). The 5-year patient survival recorded is in the range of 59.2 % (in one of the subgroups described by Orandi et al. ) when the other HLAi subgroup does offer similar figures to the rest of the studies, around 86 % survival and the 5-year value provided by Kim et al. which registered 95.8 %. In general, for LDKT with ABO incompatibility, the results of the previous review from 2012 are maintained, with a 1-year graft survival in ABOi-type living donor kidney transplants recorded in up to 8 of the 19 included studies and one 84 % minimum (Bachmann et al. 2018). For patient survival at 1 year, it is 100 % or very close in all the studies on ABOi and figures are high, but somewhat lower, for patient survival at five years (between 92 % of Melexopoulus et al. and 97.7 % from Subramanian et al.). Conclusions There is great variability in the information presented by the studies, so that it make difficult to group together. The quality of the evidence is very limited, as these are case series studies with a high risk of bias, many without a control group, and others with comparative cohort results (historical retrospectives). However, the results shown are consistent and the claims of the previous 2012 report are maintained. Graft survival and patient survival for patients undergoing HLA-incompatible LDKT are high and comparable to values offered by ABOi transplants and ABO compatible transplants. In the studies on LDKT with ABOi data, the results collected on both survival variables maintain the statements of the previous report, remaining at high values. A single localized study about economic efficiency aspects was carried out in the United States, the authors conclude that the LDKT can be an efficient option in terms of cost per QALY, although this conclusion is not directly transferable to our National Health System.
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Barsoum, Rashad S. Schistosomiasis. Edited by Neil Sheerin. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0182_update_001.
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AbstractSchistosomiasis is a parasitic disease that affects millions of people in 78 countries, where it is held responsible for considerable morbidity and mortality. It is caused by a blood fluke, which provokes an immunological response to hundreds of its antigens. This induces multi-organ pathology through the formation of tissue granulomata or circulating immune complexes. In addition, it is amyloidogenic and carcinogenic, through the interaction of immunological perturbation with confounding metabolic and genetic factors. The primary targets of schistosomiasis are urinary and hepatointestinal.The lower urinary tract is mainly affected in S. haematobium infection, and may lead to chronic pyelonephritis and/or obstructive nephropathy. The colon and liver are the targets of S. mansoni and S. japonicum infection, leading to hepatic fibrosis, portal hypertension, and liver failure. S. mansoni may also lead to immune complex glomerulonephritis, which is discussed elsewhere. Both S. haematobium and S. mansoni ova may be carried with the venous circulation to the lungs, where they provoke granulomatous and immune-mediated endothelial injury leading to cor-pulmonale. Ova may be subsequently carried with the arterial circulation to form ‘metastatic’ granulomas in other tissues, notably the brain (S. japonicum), spinal cord (S. haematobium), skin, conjunctiva, and genital organs.Schistosomiasis is preventable. World Health Organization programmes have successfully eradicated or reduced the incidence of infection in many countries, particularly Egypt and China. Prevention strategies include health education, raising hygiene standards, and interruption of the parasite’s life cycle by snail control and mass treatment. The search for a vaccine continues. Effective antiparasitic treatment is now possible with high elimination rates. Available agents include praziquantel and artemether for all species, metrifonate for S. haematobium, and oxamniquine for S. mansoni. Successful outcome correlates with early intervention, before fibrosis has occurred.
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Carrero, Juan Jesús, Hong Xu, and Bengt Lindholm. Diet and the progression of chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0101.
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The dietary management of non-dialysed CKD patients has focused on limiting the intake of substances which lead to accumulation of urea, potassium, phosphorus, and sodium. Recent advances in nutritional epidemiology have given us the opportunity to examine the relationships between diet and CKD. This chapter focuses on evidence relating to retarding progression of renal impairment in the early to mid stages of CKD. Limits may need to change if GFR falls. The hypothesis that a high dietary protein intake leads to progressive CKD through a mechanism of glomerular hyperfiltration has been taught for decades, and it appears effective in animals. However, the evidence that low-protein diets (LPDs) halt CKD progression in patients is weak. Their management is of course likely to include other interventions such as blood pressure control. There is risk to low-protein diets. There is some evidence that high protein intakes are harmful. We therefore recommend moderate protein intake (not low; not high – no protein supplements; around 1g/kg/day). Salt handling is impaired in most patients with CKD, probably even early stages, and hypertension is an early feature, except in salt-losing patients, to whom different rules apply. Salt intake tends to raise blood pressure, worsen proteinuria, and reduce the effects of angiotensin converting enzyme inhibitors on blood pressure and proteinuria. Very low salt intakes are difficult to comply with and limit diet. In early stages of CKD we therefore recommend restriction to moderately low levels (below 6g/day of salt; 100 mmol of sodium). Lower levels may have additional benefits, and these limits may need to be reduced as GFR declines. Potassium is associated with healthy, desirable foods such as fruit and vegetables. It should only be restricted if high serum values make this necessary.
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Thurston, Anne, ed. A Matter of Trust. University of London, 2020. http://dx.doi.org/10.14296/1220.9781912250356.
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The United Nations Sustainable Development Goals initiative has the potential to set the direction for a future world that works for everyone. Approved by 193 United Nations member countries in September 2016 to help guide global and national development policies in the period to 2030, the 17 goals build on the successes of the Millennium Development Goals, but also include new priority areas, such as climate change, economic inequality, innovation, sustainable consumption, peace and justice. Assessed against common agreed targets and indicators, the goals should facilitate inter-governmental cooperation and the development of regional and even global development strategies. However, each goal presents considerable challenges in terms of collecting and analysing relevant data and producing the statistics needed to measure progress. Most governments in lower resourced countries simply do not yet have the systems and controls in place to produce high quality, reliable data and statistics, and it is questionable whether the quality and integrity of the available information is adequate to support meaningful decisions and set direction for the future. There are substantial implications: where progress cannot be measured accurately because of inadequate or flawed statistics, the result can be misguided decisions, doubts about achievement of the goals and significant wasted resources. Getting statistics ‘right’ depends upon the quality and integrity of the data used to produce them and on the quality of the processes for collecting, manipulating and analysing the data. Without a documentary records as evidence of how the data were gathered and analysed or how statistics were produced and disseminated, it is not possible to confirm that the statistics are complete, accurate and relevant. Various global organisations do recognise the importance of high quality data and statistics for measuring the SDG indicators reliably, but there has been little attention to the role of records in providing the evidence needed to trust the data and statistics. There is, moreover, a lack of awareness that digital information simply will not survive without policies and procedures to manage and preserve it through time. As a result, digital data, statistics and records are being lost regularly on a large scale, particularly in lower resource countries, where the structures needed to protect and preserve them are not yet in place. This book explores, through a series of case studies, the substantial challenges for assembling reliable data and statistics to address pressing development challenges, particularly in Africa. Hopefully, by highlighting the enormous potential value of creating and using high quality data, statistics and records as an interconnected resource and describing how this can be achieved, the book will contribute to defining meaningful and realistic global and national development policies in the critical period to 2030.