Journal articles on the topic 'Lower-Aragon'

As campuses become increasingly diverse, it is important that faculties maintain inclusive classrooms. Students of underrepresented ethnic/racial groups are more likely to experience disengagement in an academic setting (Nagasawa & Wong, 1999), which can lead to underperformance (Major et al., 1998). Students with LGBTQA+ (lesbian, gay, bisexual, transgender, queer, or asexual) identities are at higher risk of poor mental health and lower academic performance compared to cisgender and heterosexual students (Aragon et al., 2014). These detrimental experiences can lead to even more harm in a remote learning environment, where students have fewer opportunities to feel a sense of belonging and connect with their peers and/or instructors. This paper will consider strategies of inclusiveness in the online classroom and in-person learning environment within a social psychology framework to better support underprivileged students to improve academic performance and the overall educational experience. The suggestions and discussions provided apply to both in-person learning as well as remote delivery.

This work compared the responses of a consumer survey on beliefs and attitudes towards dry-cured ham and protected designation of origin (PDO) Teruel ham carried out in two Spanish regions differing in Teruel ham knowledge: Aragon (high knowledge) and Catalonia (lower knowledge). Results revealed that only small differences were found regarding dry-cured ham consumption habits. With regard to beliefs related to factors affecting ham quality, differences were even lesser; raw material and maturing process, as well as marbling, colour and flavour and proper saltiness were rated as the most important quality factors. Nevertheless, large significant differences were evident between both regions in knowledge, consumption, beliefs and attitudes towards PDO Teruel ham. However, there were no differences regarding the willingness to pay a higher price for PDO ham. Multiple correspondence analysis of all data revealed large effects of age, education, income level and size of the place of residence, independent from the region of origin of the consumer.

Most of the studies analyzing the effect of moderate to vigorous physical activity (MVPA) on children’s health do not contain information on early stages or do not use accurate methods. We investigated the association between PA and body composition using objective methods, perinatal data, lifestyle behaviors, and World Health Organization (WHO) physical activity (PA) recommendations. The CALINA study is a longitudinal observational cohort study of children born in Aragon (Spain) in 2009. A total of 308 7-year-old children (52.3% boys) were assessed. We used dual-energy X-ray absorptiometry (DXA) and accelerometry. Rapid weight gain until 12 months and lifestyle behaviors were considered as covariates both in the ANCOVA and linear regression models. A higher percentage of boys met the WHO PA recommendations compared to girls (69.6% vs. 40.9%, respectively; p < 0.001). There was a negative association between MVPA and subtotal fat and abdominal fat in both girls and boys. After adjusting for perinatal and lifestyle variables, we found that subtotal body fat, abdominal fat, and fat mass index (FMI) were significantly lower in those classified as active. MVPA was associated with body fat both in boys and girls. More research is needed to identify the cutoffs points of MVPA that generate benefit to boys and girls in all body composition components.

The association between APOE genotypes and cardiovascular disease (CVD) is partially mediated by LDL-cholesterol concentration but persists after adjusting for lipid levels and other cardiovascular risk factors. Data from the Aragon Workers Health Study (AWHS) (n = 4159) and the Lipid Unit at the Hospital Universitario Miguel Servet (HUMS) (n = 3705) were used to investigate the relationship between C-reactive protein (CRP) levels and APOE genotype. Lipoprotein particle and GlycA concentrations were analyzed in a subsample from AWHS. APOE genotyping was carried out by the Sanger method in both cohorts. APOE4 carriers had significantly lower levels of CRP than APOE3 carriers. Furthermore, APOE4 carriers had cholesterol-enriched LDL particles compared to APOE2 carriers. APOE4 carriers also had higher concentrations of small, medium, and large LDL particles. CRP levels were not associated with lipoprotein particle number, size, or composition. GlycA levels were not associated with APOE genotypes. However, GlycA levels were significantly associated with the size and the amount of cholesterol contained in HDL, VLDL, and LDL particles. APOE genotype influences CRP concentration regardless of lipid profile. APOE2 carriers showed the highest CRP levels, followed by APOE3 and APOE4. A more atherogenic lipid profile, but not inflammatory markers could partly explain the higher CVD risk observed in APOE4 carriers.

We sought to identify specific profiles of new lipid-lowering drug users based on adherence to a healthy lifestyle and persistence with medication, and to characterize co-morbidities, co-treatments, and healthcare utilization for each of the profiles identified. Observational study in 517 participants in the Aragon Workers’ Health Study (AWHS) without previous cardiovascular disease (CVD) and who initiated lipid-lowering therapy. Data were collected from workplace medical examinations and administrative health databases (2010–2018). Using cluster analysis, we identified distinct patient profiles based on persistence with therapy and lifestyle. We then compared characteristics, morbidity, and healthcare utilization across clusters. Participants were aggregated into four clusters based on persistence with therapy, smoking status, adherence to Mediterranean diet, and physical activity. In cluster 1 (n = 113), comprising those with a healthiest lifestyle (14.2% smokers, 84.0% with medium-high adherence to Mediterranean diet, high physical activity), 16.8% were persistent. In cluster 3 (n = 108), comprising patients with the least healthy lifestyle (100% smokers, poor adherence to the Mediterranean diet, low level of physical activity), all were non-persistent. Clusters 2 (n = 150) and 4 (n = 146) both comprised patients with intermediate lifestyle behaviors, but differed in terms of persistence (100 and 0%, respectively). Compared with other clusters, the burden of morbidity, cardiovascular score, and healthcare utilization were lower in cluster 1. The healthy adherer effect was only observed in new lipid-lowering drug users of certain profiles. Furthermore, we found that differences in adherence to lifestyle and medication recommendations for CVD prevention influenced morbidity burden and healthcare utilization.

Background Long COVID patients suffer a negative impact on their quality of life, as well as their functioning, productivity or socialization. There is a need to better understand the individual experience and circumstances surrounding these patients. Objective To characterize clinical picture of Long COVID patients and to identify factors associated with quality of life. Methods A secondary data analysis from a randomized clinical trial (RCT) was carried out with 100 Long COVID patients treated by Primary Health Care and residents in the territory of Aragon (northeast of Spain). The main variable of the study was quality of life, evaluated using the SF-36 Questionnaire, in relation to socio-demographic and clinical variables. In addition, ten validated scales were used that contemplated their cognitive, affective, functional and social status, as well as personal constructs. Correlation statistics and linear regression model were calculated. Results Long COVID patients suffer a decrease in their levels of physical and mental health. On the one hand, the higher number of persistent symptoms (b = -0.900, p = 0.008), worse physical functioning (b = 1.587, p = 0.002) and sleep quality (b = -0.538, p = 0.035) are predictors of worse quality of life, physical subscale. On the other hand, higher educational level (b = 13.167, p = 0.017), lower number of persistent symptoms (b = -0.621, p = 0.057) and higher affective affectation (b = -1.402, p<0.001) are predictors of worse quality of life, mental subscale. Conclusion It is necessary to design rehabilitation programs that consider both the physical and mental health of these patients, thus obtaining an improvement in their quality of life.

Aim of study: This research explores consumers’ acceptance and sensory evaluation, and measures the willingness to pay (WTP) for the most important attributes of a locally grown fresh potato variety. Area of study: Aragon, Spain. Material and methods: Data were collected from two experiments. Experiment 1 (shopping stage) explored the product positioning and reveals consumers’ acceptance using three measurements: visual appearance rating, purchase intent, and WTP. Experiment 2 (consumption stage) corresponds to a sensory ranking task (e.g., taste, smell, texture) conducted at home once the local potato was fried. Main results: Consumers positively valued the visual appearance and were willing to purchase the local potato. The higher the ratings of visual appearance, the higher the consumers’ intention to purchase the product. Women and participants who purchased food from supermarkets were more likely to buy the local potato. Conversely, consumers over 55 years old and those who belong to a lower level of household monthly income were willing to pay less for the local potato. After tasting, the participants’ rating of the product remained unchanged; however, there was a negative rating of the odor once the local potato was fried. Research highlights: Potato producers and vendors should consider that consumers associate the local origin label with observable (e.g., appearance of color, shape) and unobservable (e.g., taste, smell, texture) attributes. Therefore, in addition to promoting the local origin and the benefits of purchasing and consuming local food, further consideration should be given to featuring physical quality aspects such as the sensory properties of the food that are important to consumers.

IntroductionThe evidence currently available from enhanced recovery after surgery (ERAS) programmes concerns their benefits in the immediate postoperative period, but there is still very little evidence as to whether their correct implementation benefits patients in the long term. The working hypothesis here is that, due to the lower response to surgical aggression and lower rates of postoperative complications, ERAS protocols can reduce colorectal cancer-related mortality. The main objective of this study is to analyse the impact of an ERAS programme for colorectal cancer on 5-year survival. As secondary objectives, we propose to analyse the weight of each of the predefined items in the oncological results as well as the quality of life.Methods and analysisA multicentre prospective cohort study was conducted in patients older than 18 years of age who are scheduled to undergo surgery for colorectal cancer. The study involved 12 hospitals with an implemented enhanced recovery protocol according to the guidelines published by the Spanish National Health Service. The intervention group includes patients with a minimum implementation level of 70%, and the control group includes those who fail to reach this level. Compliance will be studied using 18 key performance indicators, and the results will be analysed using cancer survival indicators, including overall survival, cancer-specific survival and relapse-free survival. The time to recurrence, perioperative morbidity and mortality, hospital stay and quality of life will also be studied, the latter using the validated EuroQol Five questionnaire. The propensity index method will be used to create comparable treatment and control groups, and a multivariate regression will be used to study each variable. The Kaplan-Meier estimator will be used to estimate survival and the log-rank test to make comparisons. A p value of less than 0.05 (two-tailed) will be considered to be significant.Ethics and disseminationEthical approval for this study was obtained from the Aragon Ethical Committee (C.P.-C.I. PI20/086) on 4 March 2020. The findings of this study will be submitted to peer-reviewed journals (BMJ Open, JAMA Surgery, Annals of Surgery, British Journal of Surgery). Abstracts will be submitted to relevant national and international meetings.Trial registration numberNCT04305314.

Abstract Background Patients with Inflammatory Bowel Disease (IBD) suffer from a chronic illness and many of them need immunosuppressive therapy throughout the course of the disease. Consequently, COVID-19 pandemic has caused uncertainty about the possible increased risk of suffering SARS-CoV-2 infection that could confer IBD or its treatments. The aim of this study is to assess SARS-CoV-2 seroprevalence in patients with IBD as well as the existence of potential risk factors for its development. Methods This is a unicentric cross-sectional study developed in IBD unit of University Hospital “Lozano Blesa” of Zaragoza. Patients older than 18 years with established diagnosis of Crohn′s Disease (CD), Ulcerative Colitis (UC) or Indeterminate Colitis (IC) have been included. A blood sample has been drawn from each patient to detect IgG against SARS-CoV-2 (ELISA method) and each patient has completed a questionnaire to know symptoms related to infection and previous comorbidity. We have performed a descriptive analysis and a univariate analysis to study relationship between potential risk factors and seroconversion against SARS-CoV-2. Results 431 patients have been included, with a mean age of 50.2 ± 14.1 years and a 51.3% of women. Of them, 49.7% suffer from UC, 49.2% CD and 1.2% IC. Related to the treatment, 23.5% receive anti-TNF biologic agents, 13.1% other kind of biologic agents, 9.3% immunomodulators, 7.7% combined treatment (biologic agent and immunomodulator), 33.1% other treatment and 13.3% no treatment. According to World Health Organization (WHO) definitions, 85.6% had not suffered the infection, 7.7% were confirmed cases (only 3 admitted patients) and 6.7% were probable cases. The seroprevalence of SARS-CoV-2 obtained is 8.8%, being significantly higher among confirmed cases than among probable cases (71.0% in confirmed vs 6.9% in probable; RR 10.3; p&lt;0.001). A higher risk of seroconversion has been detected among patients without biologic agents (11.8% in patients without biologic agents vs 5.3% in patients with biologic agents; RR 2.2; p=0.021). No differences have been observed in the seroprevalence of patients with other treatments for IBD or in terms of age, active smoking, level of inflammation markers, the presence of symptoms of infection or hospital admission. Conclusion The seroprevalence of SARS-CoV-2 of Aragon′s patients with IBD is similar to that described in national seroprevalence study of Ministry of Health for the region (8.8%). The treatment with biologic agents is associated with a lower risk of seroconversion

Abstract Background: TAPUR is a phase II basket study evaluating anti-tumor activity of commercially available targeted agents in pts with advanced cancers with specific genomic alterations. Results in a cohort of pts with solid tumors with ATM mutation (mut) or deletion (del) treated with O are reported. Methods: Eligible pts had solid tumors, no standard treatment (tx) options, measurable disease, ECOG Performance Status (PS) 0-2, and adequate organ function. Genomic testing was performed in CLIA-certified, CAP-accredited site selected labs. Pts received O tablets (300mg) or capsules (400mg) orally twice daily until disease progression. Low accruing histology-specific cohorts with the same genomic alteration were collapsed into one histology-pooled cohort for this analysis. Primary endpoint was disease control (DC) (complete (CR) or partial (PR) response or stable disease at 16+ wks (SD16+)) (RECIST v1.1). For histology-specific cohorts a Simon 2-stage design with a null DC rate of 15% vs. 35% (power = 0.85; α = 0.10) requires 28 pts with futility stopping after 10 pts. For histology-pooled cohorts with sample size &gt; 28, if the lower limit of a one-sided 90% CI is &gt;15%, the null hypothesis of a DC rate of 15% is rejected. 2-sided 95% CIs were used for other efficacy endpoint estimates. Secondary endpoints were progression-free survival (PFS), overall survival (OS) and safety. Results: 39 pts with solid tumors (17 histologies) with ATM mut (n=36) or del (n=3) were enrolled from 6/2016 to 1/2019. 3 pts were unevaluable for efficacy. Table 1 shows demographics and outcomes. 1 CR (prostate), 2 PR (unknown primary) and 6 SD16+ were observed in pts with ATM mut for a DC rate of 25% (90% CI: 16%, 100%) and an OR rate of 8% (95% CI: 2%, 23%). The null DC rate was rejected. 9 pts had ≥1 Grade 3 tx-related adverse or serious adverse event related to O. Conclusions: Monotherapy O showed evidence of anti-tumor activity in pts with various solid tumors with ATM mut. Table 1. Demographics and Baseline Characteristics (N=39); Efficacy Outcomes (N=36); Toxicity Outcomes (N=39) Median (Med) age, years (range) 65 (35, 77) Female, % 46 ECOG PS, % 0 33 1 59 2 8 Prior systemic regimens, % 0 3 1 8 2 15 ≥3 74 DC rate, % (OR or SD 16+) (1-sided 90% CI) 25 (16, 100) OR rate, % (95% CI) 8 (2, 23) Med PFS, wks (95% CI) 8.4 (8.0, 15.9) Med OS, wks (95% CI) 40.4 (30.3, 50.7) Med duration OR (range), wks 18.9 (4.3, 24.4) Med duration SD16+ (range), wks 27.3 (19.4, 31.0) Number of pts1 with treatment-related adverse or serious adverse events (all Grade 3) AE2 9 SAE3 4 1Patients may have experienced one or more events2anemia, anorexia, dehydration, fatigue, hypokalemia, nausea 3colitis, dizziness, lung infection, proteinuria, urinary tract infection/obstruction Citation Format: Kathryn F. Mileham, Michael Rothe, Pam K. Mangat, Elizabeth Garrett-Mayer, Eddy S. Yang, Olatunji B. Alese, Angela Jain, Herbert L. Duvivier, Phillip Palmbos, Eugene R. Ahn, Jeanny B. Aragon-Ching, Kathleen W. Beekman, Deepti Behl, Funda Meric-Bernstam, Rodolfo Gutierrez, Amy Sanford, Ramya Thota, Michael Zakem, Song Zhao, Raegan O'Lone, Gina N. Grantham, Susan Halabi, Richard L. Schilsky. Olaparib (O) in patients (pts) with solid tumors with ATM mutation or deletion: Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) Study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT110.

The sources influencing Shakespeare’s representation of racialized queens continue to shape popular media representations of queenship. In this article, I argue that Juan Luis Vives’ Instruction of a Christian Woman influenced Shakespeare’s representation of Katherine of Aragon’s idealized whiteness in All is True (Henry VIII). Moreover, I show how Vives and Shakespeare in turn influence Starz’s 2019 The Spanish Princess. Firstly, I how Vives represents the domestic space of the royal household a form of racial enclosure intended to manage the paradoxical confluence of the queen’s biological reproductivity and the social circulation of her image. Katherine’s patronage of Vives demonstrates her agency in cultivating her cult of queenship through gendered and racially charged notions of kinship, conduct, and labor. These tropes elevate the racial purity of the queen through and at the expense of lower class and enslaved peoples whose work is often rendered invisible. I also argue that Vives and Shakespeare’s praise of Katherine’s exemplary kinship, conduct and labor function as compensatory mechanisms that serve to reify Katherine’s whiteness even as her marriage to Henry VIII is failing. While Starz’s The Spanish Princess recasts Katherine of Aragon’s story through the contemporary lens of #MeToo and #BlackLivesMatter, it nevertheless borrows from Shakespeare and Vives’ construction of queenly whiteness at the expense of racial others.

In recent years, international research has turned with renewed attention to the Hungarian early renaissance and the art patronage of King Matthias Corvinus. indeed, it was in Hungary that italian renaissance art first appeared outside the italian peninsula. in 1476, he married Beatrice, daughter of Ferdinando d’aragona (Ferrante), who brought to Buda a love of books and music she had inherited from her grandfather, alfonso d’aragona. the work of Beatrice’s brother, giovanni d’aragona, previously known mainly from thomas Haffner’s monograph on his library (1997), is presented here from the viewpoint of his influence on Matthias’s art patronage. Ferrante’s children, alfonso, Beatrice, and giovanni were educated by outstanding humanist teachers. giovanni acquired many church benefices, and when Pope sixtus iv created him cardinal at the age of twenty-one, he made a dazzling entrance to rome. John was – together with Marco Barbo, oliviero Carafa, and Francesco gonzaga – one of the principal contemporary patrons of the College of Cardinals.On 19 april 1479 the pope named him legatus a latere to support King Matthias’s planned crusade against the Porte. giovanni went from rome to Hungary via Ferrara and Milan with two noted humanists in his retinue: the encyclopedist raffaele Maffei (volaterranus) and Felice Feliciano, bookbinder and collector of roman inscriptions. He spent much of his eight-month stay in Hungary with Matthias and Beatrice, no doubt exerting a significant influence on them, particularly in the collecting of books. Matthias appointed his brother-in-law archbishop of esztergom, the highest clerical office in Hungary. leaving Hungary in July 1480, giovanni returned to rome via venice and Florence, where lorenzo de’ Medici showed him the most valuable works of art in his palace. giovanni was appointed legate to Hungary again by sixtus iv in september 1483, and – together with Francesco Fontana – he stayed in Buda and esztergom between october 1483 and June 1484. the royal couple presented him with silver church vessels, a gold chalice, vestments, and a miter.Giovanni’s patronage focused on book collecting and building. He spent an annual sum of six thousand ducats on his library, and his acquisitions included contemporary architectural treatises by alberti and Filarete. it was around the time he was in Buda – between 1479 and 1481 – that the first large-format luxury codices were made for Matthias and Beatrice by the excellent Florentine miniaturist, Francesco rosselli. in rome, giovanni (and Francesco gonzaga) employed the Paduan illuminator gaspare da Padova, and his example encouraged Matthias and Beatrice to commission all’antica codices. anthony Hobson has detected a link between Queen Beatrice’s Psalterium and the livius codex copied for giovanni: both were bound by Felice Feliciano, who came to Hungary with the Cardinal. Feliciano’s probable involvement with the erlangen Bible (in the final period of his work, probably in Buda) may therefore be an important outcome of the art-patronage connections between giovanni and the king of Hungary.A passion for building was something else that giovanni shared with Matthias. He built a palace for himself in the monastery of Montevergine and another near Montecassino, of which he was abbot. He also built the villa la Conigliera in Naples. Matthias’ interest in architecture is much mentioned in antonio Bonfini’s history of Hungary, but only fragments of his monumental constructions, which included the renaissance villa Marmorea in the gardens to the west of the royal Palace of Buda, have survived.Giovanni and Matthias also had a connection through the famous Milan goldsmith Cristoforo Foppa (Caradosso), whose workshop was located in giovanni’s palace in rome. after his patron’s death in autumn 1485, he attempted to sell a – subsequently famous – silver salt cellar he had been unable to complete. it may also have been at the Cardinal’s recommendation that Matthias invited Caradosso to Buda for a several-month stay in 1489/90, during which he made silver tableware and possibly – together with three other lombardian goldsmiths who were there at the time – the lower part of the magnificent Matthias Calvary.Further items in the metalware category are our patrons’ seal matrices. My research has uncovered two smaller seals, both with the arms of the House of aragon at the center, that belonged to giovanni d’aragona. one, dating from 1473, is held in the archives of the Benedictine abbey of Montecassino. the other was made after he was created cardinal in late 1477 (it is held in Hungarian National archives). He also had an elaborate prelate’s seal matrix made in the early renaissance style, of which impressions survive on the documents in the archivio apostolico vaticano and the esztergom Primatial archive. at the center of the mandorla-shaped field, sitting on a throne, is the virgin Mary (Madonna lactans type) together with two intervening standing saint figures whose identification requires further research. Beneath it is the cardinal’s coat of arms crowned with a hat. it may date from the time of Caradosso’s first presumed stay in rome (1475–1479), suggesting him as the maker of the matrix, although to my knowledge there is no further evidence for this. the seals of King Matthias have been thoroughly studied, and the form and use of each type have been almost fully established.Giovanni d’aragona was buried in rome, in his titular church, the Dominican Basilica of santa sabina. Johannes Burckard described the funeral procession from the palace to the aventine in his Liber notarum. Matthias died in the vienna Burg, a residence he had only just taken up, in 1490. His body was taken in grand procession to Buda and subsequently to Fehérvár Basilica, the traditional burial place of Hungarian kings. the careers of giovanni and Matthias, full of military, political and ecclesiastical accomplishments, were thus both cut short. the great works of art they engendered, however, mark them out as highly influential patrons of renaissance art and humanist culture.

IntroductionPrevious research has indicated that the COVID-19 outbreak had a negative impact on the diagnosis and management of cardiometabolic diseases. Our aim was to analyze the impact of the COVID-19 pandemic on the management of dyslipidemia and type 2 diabetes (T2D) in the Aragon region of Spain.MethodsWe conducted an observational retrospective study, which included data from all patients diagnosed with active T2D or dyslipidemia in Aragon during 2019–2021. Data was collected from the BIGAN platform, a big database that includes all healthcare data from the Aragon population. Clinical, biochemical, and pharmacological prescription information was obtained for each patient and for each year.ResultsOut of the total population of 1,330,000 in the Aragon region, 90,000 subjects were diagnosed with T2D each year, resulting in a prevalence of approximately 7%. The COVID-19 pandemic resulted in a decrease in the prevalence of this disease and a lower incidence during the year 2020. In addition, patients with T2D experienced a deterioration of their glucose profile, which led to an increase in the number of patients requiring pharmacological therapy. The prevalence of dyslipidemia was approximately 23.5% in both 2019 and 2020 and increased to 24.5% in 2021. Despite the worsening of the anthropometric profile, the lipid profile improved significantly throughout 2020 and 2021 compared to 2019. Moreover, the number of active pharmacological prescriptions increased significantly in 2021.DiscussionOur findings suggest that the overload of the health system caused by the COVID-19 pandemic has resulted in an underdiagnosis of T2D. Moreover, patients with T2D experienced a worsening of their glycemic profile, an increase in their pharmacological requirements, and lower performance of their analytical determinations. Dyslipidemic subjects improved their lipid profile although the value of lipid profile determination decreased between 2020 and 2021.

Abstract Background There is little verified information on global healthcare utilization by irregular migrants. Understanding how immigrants use healthcare services based on their needs is crucial to establish effective health policy. We compared healthcare utilization between irregular migrants, documented migrants, and Spanish nationals in a Spanish autonomous community. Methods This retrospective, observational study included the total adult population of Aragon, Spain: 930,131 Spanish nationals; 123,432 documented migrants; and 17,152 irregular migrants. Healthcare utilization data were compared between irregular migrants, documented migrants and Spanish nationals for the year 2011. Multivariable standard or zero-inflated negative binomial regression models were generated, adjusting for age, sex, length of stay, and morbidity burden. Results The average annual use of healthcare services was lower for irregular migrants than for documented migrants and Spanish nationals at all levels of care analyzed: primary care (0.5 vs 4 vs 6.7 visits); specialized care (0.2 vs 1.8 vs 2.9 visits); planned hospital admissions (0.3 vs 2 vs 4.23 per 100 individuals), unplanned hospital admissions (0.5 vs 3.5 vs 5.2 per 100 individuals), and emergency room visits (0.4 vs 2.8 vs 2.8 per 10 individuals). The average annual prescription drug expenditure was also lower for irregular migrants (€9) than for documented migrants (€77) and Spanish nationals (€367). These differences were only partially attenuated after adjusting for age, sex, and morbidity burden. Conclusions Under conditions of equal access, healthcare utilization is much lower among irregular migrants than Spanish nationals (and lower than that of documented migrants), regardless of country of origin or length of stay in Spain.

Abstract Purpose It is suggested that polyphenols back the cardiovascular protection offered by the Mediterranean diet. This study evaluates the association of specific types of dietary polyphenols with prevalent subclinical atherosclerosis in middle-aged subjects. Methods Ultrasonography and TC were performed on 2318 men from the Aragon Workers Health Study, recruited between 2011 and 2014, to assess the presence of plaques in carotid and femoral arteries and coronary calcium. Polyphenol intake was assessed using a validated semi-quantitative 136-item food frequency questionnaire. The Phenol Explorer database was used to derive polyphenol class intake. Logistic and linear regressions were used to estimate the cross-sectional association of polyphenols intake with femoral and carotid subclinical atherosclerosis and coronary calcium. Results A higher intake of flavonoids (third vs. first tertile) was associated with a lower risk of both carotid (OR 0.80: CI 95% 0.62–1.02; P trend 0.094) and femoral (0.62: 0.48–0.80, P trend < 0.001) subclinical atherosclerosis. A higher intake of stilbenes was associated with a lower risk of femoral subclinical atherosclerosis (0.62: 0.46–0.83; P trend 0.009) and positive coronary calcium (0.75: 0.55–1.03; P trend 0.131). A higher intake of tyrosols was also associated with a lower risk of positive coronary calcium (0.80: 0.62–1.03; P trend 0.111). The associations remained similar when adjusted for blood lipids and blood pressure. Conclusion Dietary flavonoids, stilbenes, and tyrosols, whose main sources are red wine and virgin olive oil, are associated with lower prevalence of subclinical atherosclerosis in middle-aged subjects.

Abstract Background Lipoprotein(a) (Lp(a)) is a significant cardiovascular risk factor. Knowing the mechanisms that regulate its concentration can facilitate the development of Lp(a)-lowering drugs. This study analyzes the relationship between triglycerides (TG) and Lp(a) concentrations, cross-sectionally and longitudinally, and the influence of the number and composition of TG-rich lipoproteins, and the APOE genotype. Methods Data from Aragon Workers Health Study (AWHS) (n=5467), NHANES III (n=3860), and Hospital Universitario Miguel Servet (HUMS) (n=2079) were used for cross-sectional TG and Lp(a) relationship. Lp(a) intra-subject variation was studied in AWHS participants and HUMS patients with repeated measurements. TG-rich lipoproteins were quantified by nuclear magnetic resonance in a subsample from AWHS. Apolipoproteins B and E were quantified by Luminex in VLDL isolated by ultracentrifugation, from HUMS samples. APOE genotyping was carried in AWHS and HUMS participants. Regression models adjusted for age and sex were used to study the association. Results The three studies showed an inverse relationship between TG and Lp(a). Increased VLDL number, size and TG content were associated with significantly lower Lp(a). There was an inverse association between the apoE concentration in VLDL and Lp(a). No significant association was observed for apoB. Subjects carrying the apoE2/E2 genotype had significantly lower levels of Lp(a). Conclusion Our results show an inverse relationship Lp(a)-TG. Subjects with larger VLDL size have lower Lp(a), and lower values of Lp(a) were present in patients with apoE-rich VLDL and apoE2/E2 subjects. Our results suggest that bigger VLDLs and VLDLs enriched in apoE are inversely involved in Lp(a) plasma concentration.

AbstractSome studies suggest that being an apolipoprotein e4 (APOE e4) carrier increases the risk of atherosclerosis, and others suggest that cardiorespiratory fitness (CRF) could play a key role in atherosclerotic prevention. Our aim was to analyze the association of APOE e4 with carotid atherosclerosis and the association of CRF with atherosclerosis in APOE e4 carriers. A cross-sectional analysis based on a subsample of 90 participants in the Aragon Workers’ Health Study was carried out. Ultrasonography was used to assess the presence of plaques in carotid territory; the submaximal Chester Step Test was used to assess CRF; and behavioral, demographic, anthropometric, and clinical data were obtained by trained personnel during annual medical examinations. APOE e4e4 participants were categorized into Low-CRF (VO2max < 35 mL/kg/min) and High-CRF (VO2max ≥ 35 mL/kg/min) groups. After adjusting for several confounders, compared with APOE e3e3, those participants genotyped as APOE e3e4 and APOE e4e4 showed an OR = 1.60 (95% CI 0.45, 5.71) and OR = 4.29 (95% CI 1.16, 15.91), respectively, for carotid atherosclerosis. Compared to Low-CRF APOE e4e4 carriers, the odds of carotid plaque detection were 0.09 (95% CI 0.008, 0.98) times lower among High-CRF APOE e4e4 carriers. The APOE e4e4 genotype was associated with increased carotid atherosclerosis. However, CRF is a modifiable factor that may be targeted by APOE e4e4 to decrease the elevation of atherosclerotic risk due to this genetic condition.

Abstract Purpose The COVID-19 pandemic has impacted medication needs and prescribing practices, including those affecting pregnant women. Our goal was to investigate patterns of medication use among pregnant women with COVID-19, focusing on variations by trimester of infection and location. Methods We conducted an observational study using six electronic healthcare databases from six European regions (Aragon/Spain; France; Norway; Tuscany, Italy; Valencia/Spain; and Wales/UK). The prevalence of primary care prescribing or dispensing was compared in the 30-day periods before and after a positive COVID-19 test or diagnosis. Results The study included 294,126 pregnant women, of whom 8943 (3.0%) tested positive for, or were diagnosed with, COVID-19 during their pregnancy. A significantly higher use of antithrombotic medications was observed particularly after COVID-19 infection in the second and third trimesters. The highest increase was observed in the Valencia region where use of antithrombotic medications in the third trimester increased from 3.8% before COVID-19 to 61.9% after the infection. Increases in other countries were lower; for example, in Norway, the prevalence of antithrombotic medication use changed from around 1–2% before to around 6% after COVID-19 in the third trimester. Smaller and less consistent increases were observed in the use of other drug classes, such as antimicrobials and systemic corticosteroids. Conclusion Our findings highlight the substantial impact of COVID-19 on primary care medication use among pregnant women, with a marked increase in the use of antithrombotic medications post-COVID-19. These results underscore the need for further research to understand the broader implications of these patterns on maternal and neonatal/fetal health outcomes.

Anatomy and Physiology are gateway courses for students to enter allied health professions. One of the primary ways that students originating from a low socioeconomic class are able to rise to the middle class is through entry into these allied health fields (Hlinka et al 2015). At the same time, those same students of low social and cultural capital are least likely to persist in higher education (Aragon 2000) (Wells et al 2011) (Wells 2008) (Smith et al 2015). The objective of this study was to determine if students of low social and cultural capital will report a higher sense of engagement, satisfaction, perception of group work, and retention of knowledge in introductory Anatomy and Physiology as well as grit, social‐belonging, perceptions of the school's culture and peer‐interactions compared to those of high social and cultural capital when focused active learning is increased. Data were collected by pre and post class surveys of students in a second semester introductory Anatomy and Physiology course using focused active learning exercises in lecture. Control surveys were sent to students in the same course in previous semesters with no active learning exercises during lecture. Pilot study data (n=14) revealed student preference for active learning over traditional lecture and general satisfaction and engagement in the active learning activities. Additionally, lower achieving students performed slightly better on active learning‐specific exam questions compared to higher achieving students (p>0.05). Preliminary data suggest that students of low social and cultural capital have increased perceptions of learning, and an increased sense of belonging due to increased peer and faculty interactions and practical applications inherent to active learning.

Bovine brucellosis in South Africa is caused mainly by Brucella abortus biovar (bv.) 1 and less frequently by B. abortus bv. 2. Bacterial isolation is regarded as the gold standard for diagnosis of Brucella species; however, it is not very sensitive. The aim of this study was to determine the selective medium with optimum antibiotic composition that will allow the growth of Brucella species (spp.) while inhibiting moulds, yeast and most, if not all, Gram-negative contaminants in South Africa. In the controlled experiment, modified Agrifood Research and Technology Center of Aragon (CITA) medium (mCITA) seemed to be the optimum selective medium for isolation of Brucella spp. as compared with Farrell’s medium (FM) and modified Thayer Martin (mTM), while FM inhibited the growth of most fungal and bacterial contaminants. Mean comparison between the three media used to culture B. abortus resulted in lower mean difference ranging from 0 to 2.33. In case of Brucella ovis, high mean difference was obtained when comparing FM with mCITA (10.33) and mTM (12). However, the mean differences of 0.67 and 1.67 were obtained when comparing mCITA and mTM media used to, respectively, culture pasteurised and raw milk spiked with B. ovis. Further optimisation at the Agricultural Research Council – Onderstepoort Veterinary Research Institute resulted in a comparable performance between FM and mCITA; however, mCITA allowed optimal growth of the fastidious B. ovis, which is generally inhibited on FM. Generally, mCITA seemed to be the optimum selective medium for isolation of Brucella spp., while FM inhibits the growth of most fungal and bacterial contaminants. Thus, veterinary laboratories can use mCITA and/or FM but should take into consideration the detection of factious Brucella isolated in the country or region.

Abstract Background The restrictions introduced to stop the spread of the COVID-19 virus have also had a direct impact on people with chronic diseases and especially on diseases to which lifestyles are relevant in their control and management, such as diabetes, hypertension, chronic obstructive pulmonary disease (COPD), etc. The purpose of this paper is to conduct a longitudinal analysis of new comorbidities, mortality, medication use, and the use of health resources in patients with chronic diseases who did not contract COVID-19, comparing the six months before the strict lockdown to the 12 months following the end of the strict lockdown. Method An observational real world data pre-post study of 668,974 people was undertaken. The patients studied were over 16 years of age, had been receiving care from the Aragon Health Service (Northeastern Spain), were diagnosed with one or more chronic diseases, and had not contracted COVID-19. Sociodemographic, comorbidity, pharmacological and health resource use variables were collected during the six months before the onset of the lockdown and during the six and 12 months following the end of the lockdown. The comparisons by sex were carried out using a Student T-test or chi-squared test to analyse differences. Results Dyslipidaemia (42.1%) followed by hypertension (35.1%) and anxiety and depression (34.6%) were the most prevalent chronic diseases among the study population. 78.% of patients had between one and four chronic illnesses. There was a decrease in new diagnoses of other chronic comorbidities in this population and a decrease in medications prescribed and the use of health services. Although women received more diagnoses of chronic diseases, the number of medications dispensed was lower, but the use of health services was higher. These figures were maintained throughout the pandemic. Conclusion Our results suggest an underdiagnosis of new chronic comorbidities and a decrease in mortality rates from causes unrelated to COVID-19 due to the closure of health centres in Aragón (Spain) during the lockdown. This trend was exacerbated in women. The underdiagnosis of new chronic comorbidities during confinement can cause the disease to worsen, with the consequent increase in symptoms and the worsening of chronic pathologies in patients with a severe evolution.

IntroductionThe incidence of preeclampsia (PE) is about 2–8%, making it one of the leading causes of perinatal morbidity and maternal mortality in the world. Early prophylactic low dose administration (150 mg) of acetylsalicylic acid is associated with a significant reduction in the incidence of early-onset PE, intrauterine growth restriction (IUGR), and neonatal mean stay in the intensive care unit (ICU). Universal implementation of a first-trimester screening system including angiogenic and antiangiogenic markers [the Placental Growth Factor (PlGF) and/or soluble fms-like Tyrosine Kinase-1 (sFlt-1)] has shown a prediction rate of 90% for early-onset PE but entails a high financial cost. The aim of this study is to determine the predictive and preventive capacity of a universal PE first-trimester two-step sequential screening model, determining the PlGF only in patients previously classified as intermediate risk by means of a multivariate model based on resources already used in the standard pregnancy control, in a real clinical setting. We hypothesize that this screening model will achieve similar diagnostic performance as the universal determination of PlGF but at a lower economic cost.Methods and AnalysisThis is a prospective, multicentric, cohort study in a real-world clinical setting. Every singleton pregnancy will be recruited at the routine first pregnancy visit. In a first step, the first-trimester risk of PE will be calculated using a multivariate Gaussian distribution model, based on medical history, mean blood pressure, Pregnancy-Associated Plasma Protein A (PAPP-A), and Uterine Artery Doppler Pulsatility Index (UTPI). Patients will be classified into three risk groups for PE: (1) risk ≥ 1/50, high-risk with no further testing (blinded PlGF); (2) risk between 1/51 and 1/500, medium-risk requiring further testing; and (3) risk ≤ 1/501, low-risk with no further testing. In a second step, the PlGF will only be determined in those patients classified as intermediate risk after this first step, and then reclassified into high- or low-risk groups. Prophylactic administration of aspirin (150 mg/day) will be prescribed only in high risk patients. As a secondary objective, sFlt-1 values will be blindly determined in patients with high and intermediate risk to assess its potential performance in the screening for PE.Ethics and DisseminationThe study will be conducted in accordance with the principles of Good Clinical Practice. This study is approved by the Aragon Research Ethics Committee (CEICA) on 3 July 2020 (15/2020).Clinical Trial RegistrationClinicalTrials.gov, identifier: NCT04767438.

<p>Resumen: El reconocimiento de privilegios en la sociedad del Antiguo Régimen obligó a dar a cada persona un trato diferenciado en los tribunales de justicia y a imponer penas distintas a nobles y a plebeyos. Por otra parte, las aspiraciones hegemonistas de la dinastía de los Habsburgo en Europa les obligó a guerrear continuamente contra sus adversarios y a concebir una idea muy utilitaria de la administración de justicia y de la penalidad. Sobre la penalidad de los Habsburgo existen en España visiones muy contradictorias. Si atendemos a las penas previstas en el derecho y a las sentencias pronunciadas por los tribunales sacaremos una visión terrorífica del sistema judicial. Por el contrario, si nos quedamos con las fuentes que nos refieren la existencia de prácticas muy frecuentes de composiciones y acuerdos al margen del sistema judicial, obtendremos una visión edulcorada de la justicia, la cual toleraba límites de impunidad bastante elevados, sobre todo en la Corona de Aragón. En realidad ambas cosas son ciertas. El margen de arbitrio concedido a los jueces permitía una represión cruel de los delitos, eventualmente atemperada por el paternalismo atribuido a la corona y por el hecho de que primaba la actuación a petición de parte sobre la actuación de oficio, lo que permitía en una sociedad con presencia de redes clientelares profundas y extensas, resolver muchos litigios fuera del ámbito judicial. Hubo una impunidad asociada a las limitaciones de la administración de justicia en la época y otra relacionada con la existencia de componendas extrajudiciales sostenidas por el mutuo interés de las partes. Este fenómeno existió también en otros países europeos; pero, al menos en el ámbito hispánico, no debe interpretarse a priori como una manifestación de desconfianza de los súbditos en la justicia oficial. Aunque no podemos cuantificar en estos momentos el porcentaje de composiciones particulares, se puede estimar que fue inferior al de países como Inglaterra.</p><p>Abstract: Privileges recognition in the Ancient Regime forced to give a different treatment to each person in the Courts of Justice and to set different penalties to nobles and commoners. On the other hand, the hegemonic aspirations of the Habsburg dynasty in Europe continually forced them to war against their enemies and to conceive an utilitarian idea of the administration of justice and penalty. There are very contradictory ideas about Habsburgs´s penalty in Spain. By looking at the penalties provided by the law and the judgements delivered by the courts, we get a terrifying sight of the judicial system. On the contrary, analysing the sources that refer to the existence of very frequent practices of compositions and arrangements outside the court system, we get a pleasant view of justice, which was quite tolerant with the limits of impunity, especially in the Crown of Aragon. And in fact both are true. The discretion margin conceded to judges allowed a cruel repression of crime, eventually moderated because of the paternalism attributed to the crown, and also because the individual action took priority over the court-appointed action, enabling -in a society where there was deep and extensive patronage networks- to resolve many disputes out of court. There were impunity limitations associated with the administration of justice and another related to the existence of extra-judicial compromise supported by the mutual interest of the parties. This case also existed in other European countries, but, at least in the Hispanic sphere, it should not be interpreted as a display of distrust of subjects in the official justice. Although we cannot quantify the percentage of individual compositions at the moment, we can estimate that it was lower than in countries like England.</p>

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September 2015 in Heidelberg, Heidelberg 2017, Heidelberg University Publishing, 338 S., € 54,90. (Elisabeth Lobenwein, Klagenfurt) Mallinckrodt, Rebekka von / Angela Schattner (Hrsg.), Sports and Physical Exercise in Early Modern Europe. New Perspectives on the History of Sports and Motion, London / New York 2016, Routledge, XII u. 272 S. / Abb., £ 110,00. (Michael Jucker, Luzern) Mulryne, James R. / Krista De Jonge / Pieter Martens / Richard L. M. Morris (Hrsg.), Architectures of Festival in Early Modern Europe. Fashioning and Re-fashioning Urban and Courtly Space (European Festival Studies: 1450 – 1700), London / New York 2018, Routledge, XXIV u. 335 S. / Abb., £ 105,00. (Jill Bepler, Wolfenbüttel) Adelman, Howard T., Women and Jewish Marriage Negotiations in Early Modern Italy. For Love and Money (Routledge Research in Early Modern History), London / New York 2018, Routledge, XIV u. 206 S., £ 120,00. (Bettina Pfotenhauer, München) Cristellon, Cecilia, Marriage, the Church, and Its Judges in Renaissance Venice, 1420 – 1545 (Early Modern History: Society and Culture), Cham 2017, Palgrave Macmillan, XVII u. 286 S., € 96,29. (Bettina Pfotenhauer, München) Sweet, Rosemary / Gerrit Verhoeven / Sarah Goldsmith (Hrsg.), Beyond the Grand Tour. Northern Metropolises and Early Modern Travel Behaviour, London / New York 2017, Routledge, IX u. 228 S., £ 110,00. (Michael Maurer, Jena) Naum, Magdalena / Fredrik Ekengren (Hrsg.), Facing Otherness in Early Modern Sweden. Travel, Migration and Material Transformations 1500 – 1800 (The Society for Post-Mediaeval Archaeology Monograph, 10), Woodbridge 2018, Boydell Press, XVI u. 367 S. / Abb., £ 40,00. (Heiko Droste, Stockholm) Klaniczay, Gábor / Éva Pócs (Hrsg.), Witchcraft and Demonology in Hungary and Transylvania (Palgrave Historical Studies in Witchcraft and Magic), Cham 2017, Palgrave Macmillan, XIV u. 412 S., € 96,29. 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(Rotraud Ries, Würzburg) Stalljohann-Schemme, Marina, Stadt und Stadtbild in der Frühen Neuzeit. Frankfurt am Main als kulturelles Zentrum im publizistischen Diskurs (Bibliothek Altes Reich, 21), Berlin / Boston 2017, de Gruyter Oldenbourg, X u. 493 S. / Abb., € 89,95. (Johannes Arndt, Münster) Schmidt-Funke, Julia A. / Matthias Schnettger (Hrsg.), Neue Stadtgeschichte‍(n). Die Reichsstadt Frankfurt im Vergleich (Mainzer Historische Kulturwissenschaften, 31), Bielefeld 2018, transcript, 483 S. / Abb., € 49,99. (Holger Th. Gräf, Marburg) Huber, Vitus, Beute und Conquista. Die politische Ökonomie der Eroberung Neuspaniens (Campus Historische Studien, 76), Frankfurt a. M. 2018, Campus, 432 S. / Abb., € 39,95. (Laura Dierksmeier und Anna Weininger, Tübingen) Caravale, Giorgio, Preaching and Inquisition in Renaissance Italy. Words on Trial, übers. v. Frank Gordon (Catholic Christendom, 1300 – 1700), Leiden / Boston 2016, Brill, VIII u. 274 S., € 115,00. (Andreea Badea, Frankfurt a. M.) Mertens, Dieter, Humanismus und Landesgeschichte. Ausgewählte Aufsätze, 2 Teile, hrsg. v. Dieter Speck / Birgit Studt / Thomas Zotz (Veröffentlichungen der Kommission für geschichtliche Landeskunde in Baden-Württemberg. Reihe B: Forschungen, 218), Stuttgart 2018, Kohlhammer, XIV u. 1042 S. / Abb., € 88,00. (Ulrich Muhlack, Frankfurt a. M.) Grimmsmann, Damaris, Krieg mit dem Wort. Türkenpredigten des 16. Jahrhunderts im Alten Reich (Arbeiten zur Kirchengeschichte, 131), Berlin / Boston 2016, de Gruyter, XII u. 317 S., € 109,95 (Alexander Schunka, Berlin) Bauer, Joachim / Stefan Michel (Hrsg.), Der „Unterricht der Visitatoren“ und die Durchsetzung der Reformation in Kursachsen (Leucorea-Studien zur Geschichte der Reformation und der Lutherischen Orthodoxie, 29), Leipzig 2017, Evangelische Verlagsanstalt, 278 S., € 58,00. (Thomas Fuchs, Leipzig) Stegmann, Andreas, Die Reformation in der Mark Brandenburg, Leipzig 2017, Evangelische Verlagsanstalt, 279 S. / Abb., € 34,00. (Thomas Fuchs, Leipzig) Mariotte, Jean-Yves, Philipp der Großmütige von Hessen (1504 – 1567). Fürstlicher Reformator und Landgraf, übers. v. Sabine Albrecht (Veröffentlichungen der Historischen Kommission für Hessen, 24; Quellen und Darstellungen zur Geschichte des Landgrafen Philipp des Großmütigen, 10), Marburg 2018, Historische Kommission für Hessen, 301 S. / Abb., € 28,00. (Thomas Fuchs, Leipzig) Doll, Eberhard, Der Theologe und Schriftsteller Friedrich Dedekind (1524/25 – 1598). Eine Biographie. Mit einem Beitrag von Britta-Juliane Kruse zu Dedekinds geistlichen Spielen und der Erstedition der „Hochtzeit zu Cana in Galilea“ (Wolfenbütteler Forschungen, 145), Wiesbaden 2018, Harrassowitz in Kommission, 623 S. / Abb., € 92,00. (Julia Zech, Sarstedt) Bullinger, Heinrich, Tigurinerchronik, 3 Teilbde., hrsg. v. Hans U. Bächtold (Werke. Vierte Abteilung: Historische Schriften, 1), Zürich 2018, Theologischer Verlag Zürich, XXVII u. 1388 S. (Teilbde. 1 u. 2); V u. 425 S. / Abb. (Teilbd. 3), € 450,00. (Volker Leppin, Tübingen) Francisco de Vitoria, De iustitia / Über die Gerechtigkeit, Teil 1 u. 2, hrsg., eingel. u. ins Deutsche übers. v. Joachim Stüben, mit Einleitungen v. Thomas Duve (Teil 1) bzw. Tilman Repgen (Teil 2) (Politische Philosophie und Rechtstheorie des Mittelalters und der Neuzeit, Reihe I: Texte, 3 bzw. 4), Stuttgart-Bad Cannstatt 2013 bzw. 2017, Frommann-Holzboog, CXII u. 191 S. bzw. CIX u. 355 S., € 168,00 bzw. € 188,00. (Nils Jansen, Münster) Der Portulan-Atlas des Battista Agnese. Das Kasseler Prachtexemplar von 1542, hrsg., eingel. u. komm. v. Ingrid Baumgärtner, Darmstadt 2017, Wissenschaftliche Buchgesellschaft, 144 S. / Abb., € 99,95. (Christoph Mauntel, Tübingen) Brevaglieri, Sabina / Matthias Schnettger (Hrsg.), Transferprozesse zwischen dem Alten Reich und Italien im 17. Jahrhundert. Wissenskonfigurationen – Akteure – Netzwerke (Mainzer Historische Kulturwissenschaften, 29), Bielefeld 2018, transcript, 341 S. / Abb., € 39,99. (Christiane Liermann, Como) Asmussen, Tina, Scientia Kircheriana. Die Fabrikation von Wissen bei Athanasius Kircher (Kulturgeschichten, 2), Affalterbach 2016, Didymos-Verlag, 220 S. / Abb., € 39,00. (Mona Garloff, Stuttgart / Wien) Schlegelmilch, Sabine, Ärztliche Praxis und sozialer Raum im 17. Jahrhundert. Johannes Magirus (1615 – 1697), Wien / Köln / Weimar 2018, Böhlau, 352 S. / Abb., € 50,00. (Pierre Pfütsch, Stuttgart) Félicité, Indravati, Das Königreich Frankreich und die norddeutschen Hansestädte und Herzogtümer (1650 – 1730). Diplomatie zwischen ungleichen Partnern, übers. aus dem Französischen v. Markus Hiltl (Quellen und Darstellungen zur hansischen Geschichte. Neue Folge, 75), Köln / Weimar / Wien 2017, Böhlau, 439 S., € 60,00. (Guido Braun, Mulhouse) Renault, Rachel, La permanence de l’extraordinaire. Fiscalité, pouvoirs et monde social en Allemagne aux XVIIe et XVIIIe siècles (Histoire moderne, 57), Paris 2017, Éditions de la Sorbonne, 389 S. / Abb., € 25,00. (Claire Gantet, Fribourg) Godsey, William D., The Sinews of Habsburg Power. Lower Austria in a Fiscal-Military State 1650 – 1820, Oxford 2018, Oxford University Press, XX u. 460 S. / Abb., £ 90,00. (Simon Karstens, Trier) Riotte, Andrea, Diese so oft beseufzte Parität. Biberach 1649 – 1825: Politik – Konfession – Alltag (Veröffentlichungen der Kommission für geschichtliche Landeskunde in Baden-Württemberg. Reihe B: Forschungen, 213), Stuttgart 2017, Kohlhammer, LII u. 779 S., € 64,00. (Stephanie Armer, Nürnberg) Müller, Andreas, Die Ritterschaft im Herzogtum Westfalen 1651 – 1803. Aufschwörung, innere Struktur und Prosopographie (Veröffentlichungen der Historischen Kommission für Westfalen. Neue Folge, 34), Münster 2017, Aschendorff, 744 S. / Abb., € 69,00. (Nicolas Rügge, Hannover) Lange, Johan, Die Gefahren der akademischen Freiheit. Ratgeberliteratur für Studenten im Zeitalter der Aufklärung (1670 – 1820) (Beihefte der Francia, 84), Ostfildern 2017, Thorbecke, 339 S., € 45,00. 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(Georg Eckert, Wuppertal) Ducheyne, Steffen (Hrsg.), Reassessing the Radical Enlightenment, London / New York 2017, Routledge, XII u. 318 S., £ 32,99. (Bettina Dietz, Hongkong) Lehner, Ulrich (Hrsg.), Women, Enlightenment and Catholicism. A Transnational Biographical History, London / New York 2018, Routledge, XI u. 236 S. / Abb., £ 100,00. (Elisabeth Fischer, Hamburg) Möller, Horst / Claus Scharf / Wassili Dudarew / Maja Lawrinowitsch (Hrsg.), Deutschland – Russland. Stationen gemeinsamer Geschichte, Orte der Erinnerung, Bd. 1: Das 18. Jahrhundert, Berlin / Boston 2018, de Gruyter Oldenbourg, 410 S. / Abb., € 29,95. (Martina Winkler, Kiel) Bittner, Anja, Eine königliche Mission. Der französisch-jakobitische Invasionsversuch von 1708 im europäischen Kontext (Schriften des Frühneuzeitzentrums Potsdam, 6), Göttingen 2017, V&amp;R unipress, 277 S., € 45,00. (Torsten Riotte, Frankfurt a.M.) Schmidt-Voges, Inken / Ana Crespo Solana (Hrsg.), New Worlds? 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