Relevant bibliographies by topics / Low molecular weight profiling

Academic literature on the topic 'Low molecular weight profiling'

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Published: 9 March 2023
Last updated: 10 March 2023

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Journal articles on the topic "Low molecular weight profiling"

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Di Girolamo, Francesco, Jhessica Alessandroni, Paolo Somma, and Fiorella Guadagni. "Pre-analytical operating procedures for serum Low Molecular Weight protein profiling." Journal of Proteomics 73, no. 3 (January 2010): 667–77. http://dx.doi.org/10.1016/j.jprot.2009.09.006.

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Jeske, Walter, Ahmad Ahsan, and Jawed Fareed. "Molecular weight profiling of low molecular weight heparins utilizing a heparinase degraded oligosaccharide mixture as a calibrator." Thrombosis Research 70, no. 1 (April 1993): 39–50. http://dx.doi.org/10.1016/0049-3848(93)90222-a.

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Wölk, Michele, Theres Schröter, Ralf Hoffmann, and Sanja Milkovska-Stamenova. "Profiling of Low-Molecular-Weight Carbonyls and Protein Modifications in Flavored Milk." Antioxidants 9, no. 11 (November 23, 2020): 1169. http://dx.doi.org/10.3390/antiox9111169.

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Thermal treatments of dairy products favor oxidations, Maillard reactions, and the formation of sugar or lipid oxidation products. Additives including flavorings might enhance these reactions or even induce further reactions. Here we aimed to characterize protein modifications in four flavored milk drinks using samples along the production chain—raw milk, pasteurization, mixing with flavorings, heat treatment, and the commercial product. Therefore, milk samples were analyzed using a bottom up proteomics approach and a combination of data-independent (MSE) and data-dependent acquisition methods (DDA). Twenty-one small carbonylated lipids were identified by shotgun lipidomics triggering 13 protein modifications. Additionally, two Amadori products, 12 advanced glycation end products (AGEs), and 12 oxidation-related modifications were targeted at the protein level. The most common modifications were lactosylation, formylation, and carboxymethylation. The numbers and distribution of modification sites present in raw milk remained stable after pasteurization and mixing with flavorings, while the final heat treatment significantly increased lactosylation and hexosylation in qualitative and quantitative terms. The processing steps did not significantly affect the numbers of AGE-modified, oxidized/carbonylated, and lipid-carbonylated sites in proteins.
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Nylund, R., E. Lemola, S. Hartwig, S. Lehr, A. Acheva, J. Jahns, G. Hildebrandt, and C. Lindholm. "Profiling of low molecular weight proteins in plasma from locally irradiated individuals." Journal of Radiation Research 55, no. 4 (February 24, 2014): 674–82. http://dx.doi.org/10.1093/jrr/rru007.

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Zaia, Joseph, Kshitij Khatri, Joshua Klein, Chun Shao, Yuewei Sheng, and Rosa Viner. "Complete Molecular Weight Profiling of Low-Molecular Weight Heparins Using Size Exclusion Chromatography-Ion Suppressor-High-Resolution Mass Spectrometry." Analytical Chemistry 88, no. 21 (October 17, 2016): 10654–60. http://dx.doi.org/10.1021/acs.analchem.6b03081.

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Davis, Michael T., Paul Auger, Chris Spahr, and Scott D. Patterson. "Cancer biomarker discoveryvia low molecular weight serum proteome profiling – Where is the tumor?" PROTEOMICS – CLINICAL APPLICATIONS 1, no. 12 (December 2007): 1545–58. http://dx.doi.org/10.1002/prca.200700141.

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Lechner, Matthias, and Josef Rieder. "Mass Spectrometric Profiling of Low-Molecular-Weight Volatile Compounds - Diagnostic Potential and Latest Applications." Current Medicinal Chemistry 14, no. 9 (April 1, 2007): 987–95. http://dx.doi.org/10.2174/092986707780362916.

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Beyerle, Andrea, Sabrina Höbel, Frank Czubayko, Holger Schulz, Thomas Kissel, Achim Aigner, and Tobias Stoeger. "In vitro cytotoxic and immunomodulatory profiling of low molecular weight polyethylenimines for pulmonary application." Toxicology in Vitro 23, no. 3 (April 2009): 500–508. http://dx.doi.org/10.1016/j.tiv.2009.01.001.

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Baghalabadi, Venus, and Alan A. Doucette. "Mass spectrometry profiling of low molecular weight proteins and peptides isolated by acetone precipitation." Analytica Chimica Acta 1138 (November 2020): 38–48. http://dx.doi.org/10.1016/j.aca.2020.08.057.

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Davis, Michael T., Paul L. Auger, and Scott D. Patterson. "Cancer Biomarker Discovery via Low Molecular Weight Serum Profiling—Are We Following Circular Paths?" Clinical Chemistry 56, no. 2 (February 1, 2010): 244–47. http://dx.doi.org/10.1373/clinchem.2009.127951.

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Dissertations / Theses on the topic "Low molecular weight profiling"

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PADOAN, ANDREA. "Statistical methods for mass spectrometry data analysis and identification of prostaste cancer biomarkers." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50248.

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BACKGROUND Prostate Cancer (PCa) is the most common cancer among males in Europe. Patients developing early PCa sometimes refer non-specific symptoms, namely lower urinary tract symptoms (LUTS), and they usually undergo medical investigations based on Prostate Specific Antigen (PSA) and Digital Rectal Examination (DRE). Suspicious results of one or both testings are prerequisite to Prostate Biopsy. However, due to PSA low sensitivity/specificity in predicting positive prostate biopsy, the identification of new PCa biomarkers is actually a real need. MALDI-TOF/MS protein profiling could be a valuable technology for biomarkers identification. However, up to now its use is laden with lack of reproducibility that confounds scientific inferences and limits its broader use. AIMS Goal of this study is to analyze urine collected after prostatic massage in patients referring LUTS, to identify candidate biomarker for PCa, by using MALDI-TOF/MS. We considered important aspects of MALDI-TOF/MS label-free proteomic profiling, in order to assess features reproducibility and to propose appropriate strategy to handle both measurement error and limit of detection (LOD) problems. The study results should aid in reducing the number of worthless first-biopsied and assist Urologists on differential diagnosis of PCa. METHODS In a cross-sectional study, we collected urine obtained after DRE from 205 patients that referred LUTS to consultants at the Urological Unit at University of Padova. All patients undergone to prostate biopsy for suspicious PCa. Urines were dialyzed and analyzed by MALDI-TOF/MS in reflectron mode. For the MALDI-TOF/MS reproducibility evaluation, we analyzed a urine pooled from 10 reference samples, spiked with 12.58 pmol of a 1589.9 m/z internal standard (IS) peptide. For the inter-run variability assessment, 14 aliquots were dialyzed by MALDI-TOF/MS. For the intra-run study, an aliquot was divided into 26 separate sub-aliquots and analyzed by MALDI- TOF/MS. To estimate the signal detection limit (sLOD), serial dilution up to 1/256 of a urine pool were analyzed in triplicate. We evaluated the sLOD and adjusted the data appropriately to reduce its variability. We investigated six data normalization approaches - the mean, median, internal standard, relative intensity, total ion current and linear rescaling normalization. Between-spectrum and the overall spectra variability were evaluated by the coefficient of variation (CV). An optimized signal detection strategy was also evaluated to overcome peak detection algorithms errors. Measurement errors and with-in subject variances were evaluated by an external dataset, made of urine repeatedly collected from 20 reference subjects. Intra class correlation coefficient (ICC), Regression Calibration (RCAL) and SIMEX analyses were used to estimate unbiased logistic regression coefficients relating MALDI-TOF/MS features with Patients biopsy outcome. Monte Carlo simulations were used to estimate influence of different LOD adjustment methods on ICC and RCAL. RESULTS Initially, we evaluated the intra- and inter-run on data obtained from automatic peak detection. Normalization methods performed almost similarly in both studies, except IS, which resulted in an increased CV. Calculated sLOD varied with spectra m/z. After sLOD adjustment, raw and normalized data showed a reduction in CVs, while median and mean normalizations performed better, especially in the intra-assay study. However, by optimizing the peak signal detection, the overall features variability drastically decreased. Median normalization with sLOD correction remained the preferable choice for further analyses. Evaluating the external dataset, we found that most of the MALDI-TOF/MS variability is intrinsic to the biological matrix. By using substitution of below LOD values by LOD/2, simulation studies showed that ICC estimations were poorly affected by LOD, when measurement error σ is less that 0.36 and values below LOD are less that 50%. Comparing results from naïve logistic regression, RCAL and SIMEX, measurement error appeared to cause a "bias toward the null". However, SIMEX estimations seemed to correct for a smaller amount of bias than RCAL. Overall, we found eight MALDI-TOF/MS features associated with positive biopsy results. CONCLUSION Findings from the reproducibility study showed that the major contributing factor for MALDI-TOF/MS profiling variability is the peak detection process. So, a new algorithm suited for MALDI-TOF reflectron mode is desirable for its applications in profiling studies. However, normalization strategies aid in increasing MALDI-TOF/MS label-free data reproducibility, especially with sLOD correction. Despite urine does not seem to be a promising biological fluid for proteomic biomarker discovers, RCAL and SIMEX appeared valuable approaches to obtain regression coefficients adjusted for biological and instrumental errors on MALDI-TOF/MS features.
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Nightingale, Philip D. "Low molecular weight halocarbons in seawater." Thesis, University of East Anglia, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280971.

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Hoogland, J. S. "Properties of low molecular weight food surfactants." Thesis, University of Bristol, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333908.

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Abdel-Hady, Mohamed Helmy Abdel-Rahman. "Molecular genetic profiling of low grade gliomas : towards a molecular genetic classification /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486402957195399.

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Hettiarachchi, Rohan Jagath Kumara. "Venous thromboembolism, cancer and low molecular weight heparin." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/84386.

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Roberts-Thomson, Peter John. "Low molecular weight IgM in health and disease /." Title page, index and abstract only, 1987. http://web4.library.adelaide.edu.au/theses/09MD/09mdr648.pdf.

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Mauron, Thomas. "Influence of low molecular weight heparin and low molecular weight dextran sulfate on the inhibition of coagulation factor XIa by serpins /." Bern : Hämatologisches Zentrallabor der Universität Inselspital, 1998. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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Chen, Qiang. "The major chloroplast low molecular weight heat shock protein." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185849.

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The goal of this dissertation is to provide information critical for understanding the function of the major chloroplast LMW HSP. The results of this research show that the production of a nuclear-encoded, chloroplast LMW HSP is a highly conserved event in the plant HS response, and that the HSP itself is highly homologous in divergent plant species. Three major conserved regions were identified in the chloroplast LMW HSP. The carboxyl-terminal HS domain of the chloroplast LMW HSP is also found in cytoplasmic LMW HSPs and identifies it as a member of the superfamily of eukaryotic LMW HSPs. The amino-terminal region is unique to the chloroplast LMW HSP and is capable of forming a Met-rich amphipathic α-helix. The chloroplast LMW HSP cannot be detected at normal growth temperatures, but accumulates dramatically in both leaves and roots during HS. The chloroplast LMW HSP is a stable protein with a half-life of approximately 52 h. In the chloroplast, the majority of PsHSP21 is localized in the soluble protein fraction. In its native state, PsHSP21 exists in a 200 kDa particle as is observed for cytoplasmic LMW HSPs. However, unlike the cytoplasmic LMW HSPs, the PsHSP21-containing particles do not aggregate into heat shock granules even under severe, abrupt HS conditions. The formation of the PsHPS21-containing particle can be replicated in isolated chloroplasts, but the chloroplasts must be from heat stressed plants. The protein sequence homology and the similar native structure of the LMW cytoplasmic and chloroplast HSPs suggests they perform similar functions in different cellular compartments. I propose that the 200 kDa particle is the functional form of PsHSP21. Furthermore, the chloroplast LMW HSP performs functions in all types of plastids similar to those of the cytoplasmic LMW HSPs, but with unique substrates within the special environment of plastids. This study provides the first information regarding the expression and structure of the chloroplast LMW HSP. Since the chloroplast contains only a single major LMW HSP, this study also provides the basis for developing a simple model system for studies of the function of all members of the ubiquitous LMW HSP family.
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Song, Yang. "OXIDATIVE DEPOLYMERIZATION OF LIGNIN TO LOW MOLECULAR WEIGHT AROMATICS." UKnowledge, 2019. https://uknowledge.uky.edu/chemistry_etds/114.

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To date, most lignocellulosic biorefinery strategies have focused on optimizing conversion of cellulose to ethanol, leaving lignin as an underutilized biomass constituent. Lignin is engineered by nature with the intent to protect plants from chemical and biological attack; this leaves lignin with high structural irregularity and recalcitrance, rendering conversion of the lignin macromolecule to valuable products particularly challenging. Nevertheless, given that the economics of cellulosic ethanol production are strongly dependent on the value that can be obtained for the lignin co-product, the successful valorization of lignin is a crucial step in the transition towards a bio-based economy. This thesis focuses on lignin depolymerization using oxidative methods, specifically, the oxidation and cleavage of the β-O-4 linkage. Heterogeneous catalysis in this case is more desirable than homogenous catalysis as the catalyst easily recovered, and it is better suited for industrial applications. Initially, layered double hydroxide (LDH) supported gold nanoparticles were characterized and screened in the oxidation of various lignin model compounds using molecular oxygen, leading to the discovery of an Au/Li-Al LDH heterogeneous catalyst active for oxidative cleavage of the β-O-4 linkage. The Au/Li-Al LDH catalyst was then applied to oxidatively depolymerize Indulin AT kraft lignin and γ-valerolactone (GVL) extracted lignin, high yields of monomers being observed when the oxidized lignins underwent subsequent base-catalyzed hydrolysis. Thereafter, different literature oxidative lignin depolymerization methods were tested on kraft lignin and GVL lignin, and the results compared to the Au/Li-Al LDH catalyst (coupled with hydrolysis) system to determine the most effective oxidative depolymerization method.
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Rodríguez, Seco Cristina. "Low-Molecular Weight Semiconductors for Organic and Perovskite Solar Cells." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/667660.

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Actualment, les fonts d'energia renovables estan atraient molta atenció degut a l'impacte negatiu que els combustibles fòssils estan causant al planeta. Les tecnologies basades en les cel·les fotovoltaiques són una alternativa sostenible per cobrir la demanda energètica mundial. El principal objectiu d'aquest treball és el disseny i la síntesis de noves molècules per tal de reemplaçar els polímers habitualment utilitzats com a molècules captadores de llum en cel·les solars orgàniques i el spiro-OMeTAD usat com a transportador de buits (HTM per les sigles en anglès "hole transporting material") en dispositius solars de perovskita. D'una banda, els polímers són coneguts per ser bons transportadors de buits, posseir una elevada solubilitat i una bona habilitat per a la formació de capes, però entre els diferents lots existeix una baixa reproductibilitat degut a la seva síntesi complexa. D'altra banda, el spiro-OMeTAD és la molècula que millor reproductibilitat i eficiència presenta en cel·les solars de perovskita. No obstant això, la seva síntesi complexa i d’alt cost impedeix la possibilitat d'escalat a nivell industrial. Per tal de solucionar aquests problemes, aquesta tesi s'ha enfocat en el disseny, síntesi i caracterització d'un conjunt de molècules petites de baix pes molecular per a la seva aplicació en aquests dispositius.
Actualmente, las fuentes de energía renovables están atrayendo mucha atención debido al impacto negativo que los combustibles fósiles están causando al planeta. Las tecnologías basadas en las celdas fotovoltaicas son una alternativa sostenible para cubrir la demanda energética mundial. El principal objetivo de este trabajo fue el diseño y la síntesis de nuevas moléculas que reemplacen los polímeros comúnmente utilizados como moléculas captadoras de luz en celdas solares orgánicas y el spiro-OMeTAD usado como transportador de huecos (HTM por sus siglas en inglés “hole transporting material”) en dispositivos solares de perovskita. Por una parte, los polímeros son conocidos por ser buenos transportadores de huecos, su alta solubilidad y su favorable habilidad en la formación de capas, pero tienen muy poca reproducibilidad entre distintos lotes. Por otra parte, el spiro-OMeTAD es la molécula que mejor reproducibilidad y eficiencia presenta en celdas solares de perovskita. Sin embargo, su síntesis compleja y de alto coste impide la posibilidad de escalado a nivel industrial. Con el fin de solucionar estos problemas, esta tesis se ha enfocado en el diseño, síntesis y caracterización de un conjunto de moléculas pequeñas de bajo peso molecular para su aplicación en dichos dispositivos
Nowadays, renewable energy sources are attracting a lot of attention due to the undesired environmental impact the fossil fuels are causing to the Earth. Solar cells technologies are a sustainable alternative to the increasing world energy demand. The main aim of this work was to design and synthetize novel molecules that could replace the polymers widely used as absorbers in organic solar cells and spiro-OMeTAD used as a hole transporting material (HTM) in perovskite solar cells. On the one hand, polymers are known for their good hole transporting properties, high solubility and good film forming abilities but they have a poor batch-to-batch reproducibility. Furthermore, spiro-OMeTAD is the best molecule to achieve reproducible and highly efficient perovskite solar cells. However, its complex and expensive synthesis and purification hinder its usage in industrial scale photovoltaics. In order to overcome these problems, the rational design, synthesis and characterization of a variety of small molecules for both applications have been on a focus of this thesis.
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Books on the topic "Low molecular weight profiling"

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Barrowcliffe, Trevor W. Low molecular weight heparin. Chichester, West Sussex, England: Wiley, 1992.

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Kampen, Thorsten U. Low Molecular Weight Organic Semiconductors. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2010. http://dx.doi.org/10.1002/9783527629978.

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Bäckvall, Helena, and Janne Lehtiö, eds. The Low Molecular Weight Proteome. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7209-4.

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Thromoprophylaxis with low-molecular-weight heparins. London: Current Medicine Group, 2006.

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Nightingale, Philip D. Low molecular weight halocarbons in seawater. Norwich: University of East Anglia, 1991.

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Hyers, Thomas M. Treatment handbook of low-molecular-weight heparin. London: Science Press, 2000.

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Christian, Doutremepuich, ed. Low molecular weight heparins in clinical practice. New York: Dekker, 1992.

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Haug, G., and H. Hoffmann, eds. Pyrethroid Residues, Immunoassays for Low Molecular Weight Compounds. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-74846-2.

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Blass, W. Pyrethroid residues, immunoassays for low molecular weight compounds. Berlin: Springer-Verlag, 1990.

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Bäckvall, Helena. The low molecular weight proteome: Methods and protocols. New York: Springer, 2013.

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Book chapters on the topic "Low molecular weight profiling"

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Rainer, Matthias, Constantin Sajdik, and Günther K. Bonn. "Mass Spectrometric Profiling of Low-Molecular-Weight Proteins." In Methods in Molecular Biology, 83–95. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7209-4_5.

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Davis, James W., Dana Forman, La Scienya M. Jackson, James W. Davis, Javier Garau, David N. O’Dwyer, Elisa Vedes, et al. "Low Molecular Weight Heparin." In Encyclopedia of Intensive Care Medicine, 1341–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_716.

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Pineo, G. F., and R. D. Hull. "Low Molecular Weight Heparin." In Antithrombotics, 305–29. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-59942-2_10.

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Terech, P. "Low-molecular weight organogelators." In Specialist Surfactants, 208–68. Dordrecht: Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-009-1557-2_8.

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Uchegbu, Ijeoma F. "Low Molecular Weight Micelles." In Fundamentals of Pharmaceutical Nanoscience, 9–25. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9164-4_2.

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Wrona, Monika Z., and Glenn Dryhurst. "Low Molecular Weight Neurotransmitters." In Bioelectrochemistry IV, 117–69. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-2576-9_8.

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Elliott, C. Gregory. "Low Molecular Weight Heparins." In Pulmonary Embolism, 161–71. Tokyo: Springer Japan, 1999. http://dx.doi.org/10.1007/978-4-431-66893-0_12.

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Reichelt, K. L. "16 Low Molecular Weight Peptides." In Handbook of Neurochemistry and Molecular Neurobiology, 401–11. Boston, MA: Springer US, 2007. http://dx.doi.org/10.1007/978-0-387-30373-4_16.

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Stütz, P., and E. Liehl. "Low Molecular Weight Cytokine Inducers." In Strategies for Immunointerventions in Dermatology, 207–16. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60752-3_18.

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Vanholder, Raymond. "Low molecular weight uremic toxins." In Critical Care Nephrology, 855–68. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5482-6_71.

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Conference papers on the topic "Low molecular weight profiling"

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Fareed, J., J. M. Walenga, D. Hoppensteadt, R. N. Emanuele, and A. Racanell. "PHARMACOLOGIC INEQUIVALENCE OF LOW MOLECULAR WEIGHT HEPARINS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644163.

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Compared to unfractionated heparin, low molecular weight heparins (LMWHs) have been found to exhibit marked variations in in vitro effects due to variations in molecular weight and structure. Moreover, when the in vitro potency of these agents is equally adjusted bypharmacopeial assay (current and proposed) wide variations in the in vivo responses have been noted. These variations were strongly dependent on the route of administration. Utilizing defined animal models, a systematic comparative study of the in vivo responses of seven commercial LMWHs was undertaken. Choay Fraxiparine (CY 216} Choay CY 222, NovoLHN, Kabi Fragmin, Opocrin 2123 (OP), Hepar RD 11885 (RD), Pharmuka Enoxaparin (PK) and Choay porcine mucosal heparin (PMH) were tested in identical settings at equigravimetric dosages. The graded results are given in the following.Wide variations in the in vivo pharmacologic and toxicity responseswere noted suggesting that different LMWHs are not bioequivalent at equigravimetric levels. When these responses were expressed in anti-factor Xa or pharmacopeial potency, these differences were further magnified. The clinically reported dosimetric and safety problems may be minimized by profiling LMWHs in defined in vivo test systems to optimize their safety/efficacy ratio.
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Al-Hajri, Nasser M., Sulaiman Ureiga, and Akram Barghouti. "High Performance Software Computing Enables Accurate Downhole Pressure Predications for Gas Wells." In International Petroleum Technology Conference. IPTC, 2022. http://dx.doi.org/10.2523/iptc-22608-ms.

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Abstract A reservoir's static bottomhole pressure is an integral component of many reservoir evaluation disciplines. The static bottomhole pressure is normally acquired through gauge measurements; however, this method has disadvantages such as cost and mechanical risk. Accordingly, the ability to accurately estimate the static bottomhole pressure would provide a cost-effective and safe alternative to well intervention. In this work, a new cloud computing method is introduced to predict the static bottomhole pressure of a natural gas well. The method reaps the benefits of available IR 4.0 technologies, namely multi-layered high performance software computing. The utilization of an advanced software codes enabled accurate and timely prediction of gas wells’ bottomhole pressures. This method differs from existing methods by utilizing the apparent molecular weight profiling concept. Based on the inputs of pressure and temperature gradient data, an iterative calculation scheme is applied to produce a well-specific molecular weight profile. This profile is used along with a modified form of the equation of state to perform top node pressure calculations and ultimately predict the static bottomhole pressure for gas wells. The new calculation method was applied on two calculation modes: calibration mode and time lapse mode. In the calibration mode, the static bottomhole pressure is predicted on the same gradient survey used to generate the apparent molecular weight profile. On the other hand, the time lapse calculation mode predicts the static bottomhole pressure after a period of time has elapsed from the gradient survey used to build the molecular weight profile. The top node method was tested rigorously, and the prediction results were found accurate with low error percentages.
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Al-Hajri, Nasser M., Akram R. Barghouti, and Sulaiman T. Ureiga. "Gas Deviation Factor Calculation Made Easy and Accurate Using an IR 4.0 Tool." In Abu Dhabi International Petroleum Exhibition & Conference. SPE, 2021. http://dx.doi.org/10.2118/207999-ms.

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Abstract Gas deviation factor (z-factor) and other gas reservoir fluid properties, such as formation volume factor, density, and viscosity, are normally obtained from Pressure-Volume-Temperature (PVT) experimental analysis. This process of reservoir fluid characterization usually requires collecting pressurized fluid samples from the wellbore to conduct the experimental work. The scope of this paper will provide an alternative methodology for obtaining the z-factor. An IR 4.0 tool that heavily utilizes software coding was developed. The advanced tool uses the novel apparent molecular weight profiling concept to achieve the paper objective timely and accurately. The developed tool calculates gas properties based on downhole gradient pressure and temperature data as inputs. The methodology is applicable to dry, wet or condensate gas wells. The gas equation of state is modified to solve numerically for the z-factor using the gradient survey pressure and temperature data. The numerical solution is obtained by applying an iterative computation scheme as described below:A gas apparent molecular weight value is initialized and then gas mixture specific gravity and pseudo-critical properties are calculated.Gas mixture pseudo-reduced properties are calculated from the measured pressure and temperature values at the reservoir depth.A first z-factor value is determined as a function of the pseudo-reduced gas properties.Gas pressure gradient is obtained at the reservoir depth from the survey and used to back-calculate a second z-factor value by applying the modified gas equation of state.Relative error between the two z factor values is then calculated and compared against a low predefined tolerance.The above steps are reiterated at different assumed gas apparent molecular weight values until the predefined tolerance is achieved. This numerical approach is computerized to perform the highest possible number of iterations and then select the z-factor value corresponding to the minimum error among all iterations. The proposed workflow has been applied on literature data with known reservoir gas properties, from PVT analysis, and showed an excellent prediction performance compared to laboratory analysis with less than 5% error.
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Hamblin, Mark J., Yee Chan-Li, Samuel L. Collins, Robert W. Hallowell, and Maureen R. Horton. "Low Molecular Weight Statin Derivatives Inhibit Low Molecular Weight Hyaluronan Induced Inflammatory Signals." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2855.

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Shirai, Masamitsu, Akitaka Kurosima, Haruyuki Okamura, Koji Kaneyama, and Toshiro Itani. "EUV resist based on low molecular weight PHS." In SPIE Advanced Lithography, edited by Clifford L. Henderson. SPIE, 2008. http://dx.doi.org/10.1117/12.771774.

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Kumar, P. Naveen, U. Sasikala, P. Chandra Sekhar, V. B. S. Achari, V. V. R. N. Rao, A. K. Sharma, Alka B. Garg, R. Mittal, and R. Mukhopadhyay. "Discharge Characteristics of Low Molecular Weight Solid Polymer Electrolyte." In SOLID STATE PHYSICS, PROCEEDINGS OF THE 55TH DAE SOLID STATE PHYSICS SYMPOSIUM 2010. AIP, 2011. http://dx.doi.org/10.1063/1.3606028.

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Lasker, S. E., B. Y. Lee, and R. E. Madden. "LOW MOLECULAR WEIGHT HEPARINS s ORAL ABSORPTION IN MONKEYS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644855.

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An orally administered low molecular weight heparin-like derivative of the commercial polydisperse polysaccharide is desirable clinically. The dissociation of antithrombotic properties and the induction of bleeding as well as minimal effect on platelet function are characteristics of some low-molecular weight heparins; however the circulating level of the anti Xa activity associated with demonstrable theraputic efficacy is not yet defined.The availability of a variety of low molecular weight heparins provided us with the opportunity to evaluate the gastrointestinal absorption characteristics of the preparations in the primate.Average molecular weight is only one of a spectrum of variables associated with absorbability, while Xa/APTT ratio differences and non-equivalent structural alterations may be responsible for functional differences in a living test system. Nevertheless, because of the clinical potential it is instructive to evaluate the GI absorbability of several preparations for which we have precise molecular weight data.Preparations: Low molecular weight heparins were prepared by a variety of methods including isolationby alcohol fractionation from broadly polydisperse commercial or crude heparins, depolymerization of commercial or crude heparin and franctionation of depolymerization products.Methods:Molecular weights were established by equilibrium ultracentrifugation and anti Xa activity was assayed by the Yin-Wessler coagulation method. Faste rhesus monkeys weighing 8-13 kg. were anesthestized and intubated with a radio opaque catheter. One cubic centimeter of a heparin preparation in saline was instilled directly into the duodenum. Blood samples assayed for anti Xa activity and thromboelasticity were drawn at periodic intervals from an indwelling femoral catheter.Results:Standard unfractionated heparin was detectable in blood only after one-half hour. The maximum activity for low molecular weight preparations was achieved after one-half to one hour.One fraction demonstrated activity in the plasma after four hours. Thedose response curve for one fraction at half-hour wascuyvilineal between 7 and 16 Mg/Kg.
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Briel, R. C., P. C. Hermann, and P. Doller. "LOW MOLECULAR WEIGHT HEPARIN (FRAGMIN) PROPHYLAXIS IN GYNECOLOGIC SURGERY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643223.

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In a prospective, randomized study patients undergoing hysterectomy were treated either by the low molecular weight heparin Fragmin or by the combination of unfractionated sodium heparin + dihydroergotamin (HDHE). The dosage in the Fragmin group was 2× 2500 anti Xa-U on day 1 = day of surgery, from day 2-8: 1× 5000 anti Xa-U, in the HDHE-group from day 1-8: 2× 5000 IU heparin + 0.5 mg DHE. 99 patients were randomly allocated to prophylaxis with Fragmin, 101 to HDHE prophylaxis. 95 and 96 respectively were evaluated, the others excluded for different reasons. The 2 groups were comparable for general data and risk factors. Duration of surgery, intraoperative blood loss, transfusion rates and postoperative hemoglobin levels were identical. Blood volumes in subcutaneous and subfascial drainages were slightly but not significantly higher in the Fragmin group. In patients with an additional Marshall-Marchetti-operation, blood volumes in the drainages of the spatium retzii were significantly higher in patients on Fragmin. No differences were observed in the incidence of minor and major wound hematoma. Painful injections and sugillations at the injection sites were more frequently observed in the HDHE-group. The thermographic DeVeTherm test, which was carried out daily for diagnosis of DVT, gave positiv results (= temperature difference 1°C) on one day only in 14 patients of each group. The test was positive on 2 or more consecutive days in 4 patients on Fragmin and 2 patients on HDHE. Phlebography, which was carried out in the latter patients, gave a positive result in 1 patient of each group. Localization of DVT was mainly the lower limb. Plasma anti-Xa activity (S-2222) 4 hrs. after injection of 5000 anti-Xa IU Fragmin was 0.45 IU/ml being 10 fold higher than after HDHE. aPTT was slightly prolonged in both groups, thrombin time and thrombelastogramm gave even more pronounced changes in the Fragmin group. The present data indicate that Fragmin dosage should be further decreased to avoid bleeding complications.
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Hada, H., T. Hirayama, D. Shiono, J. Onodera, T. Watanabe, Seung Yoon Lee, and H. Kinoshita. "Outgassing characteristics of low molecular weight resist for EUVL." In Digest of Papers. 2004 International Microprocesses and Nanotechnology Conference, 2004. IEEE, 2004. http://dx.doi.org/10.1109/imnc.2004.245813.

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Kéna-Cohen, S., P. N. Stavrinou, D. D. C. Bradley, and S. A. Maier. "Random Lasing in Low Molecular Weight Organic Thin Films." In Frontiers in Optics. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/fio.2011.fwm5.

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Reports on the topic "Low molecular weight profiling"

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Roberts, Christine Cardinal, Alan Graham, Martin Nemer, Leslie M. Phinney, Robert M. Garcia, Melissa Marie Soehnel, and Emily Kate Stirrup. Physical Properties of Low-Molecular Weight Polydimethylsiloxane Fluids. Office of Scientific and Technical Information (OSTI), February 2017. http://dx.doi.org/10.2172/1343365.

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Gao, H. Crosslinked, flexible, low-molecular-weight polyacrylamide gels for mobility control. Office of Scientific and Technical Information (OSTI), December 1989. http://dx.doi.org/10.2172/5405561.

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Scharf, Michael E., Sam N. Nguyen, Cheol Song, and Phillip G. Koehler. Bioassay for Volatile Low Molecular Weight Insecticides and Methods of Use. Fort Belvoir, VA: Defense Technical Information Center, July 2007. http://dx.doi.org/10.21236/ada605489.

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Woods, W. T., and Jr. Mechanisms of Action of Low Molecular Weight Toxins in the Cardiovascular System. Fort Belvoir, VA: Defense Technical Information Center, October 1987. http://dx.doi.org/10.21236/ada225113.

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Ren, Tong. Hydrolytic and Peroxyhydrolytic Degradation of Nerve Agent Analogs with Low Molecular Weight Bimetallic Catalysts. Fort Belvoir, VA: Defense Technical Information Center, January 2005. http://dx.doi.org/10.21236/ada429791.

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Arenson, D. R., and C. J. King. Separation of low molecular weight alcohols from dilute aqueous solutions by reversible chemical complexation. Office of Scientific and Technical Information (OSTI), April 1989. http://dx.doi.org/10.2172/6094599.

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Wingate, Hannah F., and Khandan Keyomarsi. The Role of the Low Molecular Weight (LMW) Isoforms of Cyclin E in Breast Cancer Tumorigenesis. Fort Belvoir, VA: Defense Technical Information Center, June 2005. http://dx.doi.org/10.21236/ada443238.

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Wingate, Hannah. The Role of the Low Molecular Weight (LMW) Isoforms of Cyclin E in Breast Cancer Tumorigenesis. Fort Belvoir, VA: Defense Technical Information Center, June 2006. http://dx.doi.org/10.21236/ada457665.

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Wingate, Hannah. The Role of the Low Molecular Weight (LMW) Isoforms of Cyclin E in Breast Cancer Tumorigenesis. Fort Belvoir, VA: Defense Technical Information Center, June 2007. http://dx.doi.org/10.21236/ada475188.

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Kemppainen, B. W., M. Mehta, R. G. Stafford, R. T. Riley, and C. R. Clark. In Vitro and In Vivo Measurement of Percutaneous Penetration of Low Molecular Weight Toxins of Military Interest. Fort Belvoir, VA: Defense Technical Information Center, January 1989. http://dx.doi.org/10.21236/ada206485.

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