Dissertations / Theses: 'Low-fat diet'

1

Lee, Wen-Hui. "A comparative analysis of Midwestern attitudes when dining out." Online version, 1998. http://www.uwstout.edu/lib/thesis/1998/1998leew.pdf.

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2

Mitchell, Dorothy T. "The development and piot testing of a Cholesterol Saturated Fat Index (CSI) scorecard for dietary self-monitoring /." This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-10242009-020351/.

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Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1993.
Vita. Abstract. Accompanying booklets in pockets. Includes bibliographical references (leaves 110-121). Also available via the Internet.

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3

Schneider, Mary Katherine. "An Oxidized Fat Containing Diet Decreases Weight Gain but Increases Adiposity in Mice Fed a Low Fat Diet." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/nutrition_theses/1.

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Introduction: Fast and convenience foods are abundant, relatively inexpensive, and accommodating to the fast-paced lifestyle of many Americans. One popular method of cooking used by many fast food establishments is deep-fat frying. Soybean oil is commonly used for frying and is rich in polyunsaturated fatty acids (PUFA) such as linoleic acid (LA). When soybean oil is used for deep-fat frying, LA becomes oxidized (Ox-LA). Endogenous Ox-LA has the capacity to be a ligand to peroxisome proliferator-activated receptor gamma (PPAR¥ã), a nuclear transcription factor that regulates adipocyte maturation. It is not yet known whether or not dietary Ox-LA has the same capacity with respect to PPAR¥ã. Considering the fact that dietary oxidized lipids are abundant in the typical American diet, it is important to know if they regulate weight gain and especially adipose tissue mass. In this study, we investigate the effects of fresh and heated soybean oil on weight gain and adiposity in mice fed isocaloric low fat diets. Methods: Soybean oil was heated on a hot plate, under a hood, at 190¨¬C for three hours. Fresh soybean oil served as the source of unoxidized oil (Unox-oil) and the heated oil served as the source of oxidized oil (Ox-oil). Both the Ox-oil and Unox-oil were incorporated into a low-fat (10% of calories) mouse chow by Research Diets, Inc. (New Brunswick, NJ). Sixteen C57BL/6J mice were divided into two groups and fed low fat diets with Ox-oil (low fat oxidized, LFO) or with Unox-oil (low fat unoxidized, LFU). Another group of 8 mice were pair fed to the LFO group with the Unox-oil containing chow (PLU). Mice in the LFO and LFU groups were fed ad libitum and known amounts of fresh food was added to the cages every three days. Leftover food was weighed. Body weights were measured once a week. After 16 weeks mice were euthanized and epididymal white adipose tissue (EWAT), retroperitoneal white adipose tissue (RWAT), inguinal white adipose tissue (IWAT), and intrascapular brown adipose tissue (IBAT) samples were collected, weighed and stored at -80 degrees Celsius until further analysis. Fat pads were homogenized and cytosolic and nuclear proteins were extracted by standard methods. These extracts were subjected to Western blotting to determine the amount of PPAR¥ã in the cytosol and nuclear compartments of the fat pads. Differences in group means were analyzed by Mann Whitney U test. Comparisons were considered statistically significant at a p-value of < 0.05. Results: Final mean body weights were significantly different when comparing the mice in the LFU group to the pair fed mice (PLU) (mean ¡¾ SD; 29.52 ¡¾ 1.09 grams (g) and 26.85 ¡¾ 1.44 g, respectively; p < 0.05). Mice fed a low fat diet consisting of Ox-oil (LFO) had a final mean body weight of 27.88 ¡¾ 2.03 g. Mice in the LFU group gained significantly more weight on average than did mice in the LFO or PLU groups (mean ¡¾ SD; 8.86 ¡¾ 1.37g, 7.10 ¡¾ 1.47 g, and 5.71 ¡¾ 1.13 g, respectively). Although mean food intakes were not significantly different between any of the three groups, the average food intake was greatest for the LFU mice in comparison to the LFO and the PLU mice (mean ¡¾ SD; 20.65 ¡¾ 0.09 g/week, 18.40 ¡¾ 0.05 g/week, and 18.38 ¡¾ 0.19 g/week, respectively). Feeding efficiency (g of weight gain/g of food consumed) was the highest in the LFU mice compared to the PLU mice (mean ¡¾ SD; 0.031 ¡¾ 0.005 g/g and0.022 ¡¾ 0.004 g/g) and this difference was statistically significant. The LFO mice gained less weight per gram of food consumed than did the LFU mice (mean ¡¾ SD; 0.028 ¡¾ 0.006 g/g). Mean weights of all fat pads in the LFO group were significantly greater than those of the LFU and PLU mice (mean ¡¾ SD; 0.329 ¡¾ 0.109g, 0.199 ¡¾ 0.055g, and 0.219 ¡¾ 0.041 for EWAT, 0.091 ¡¾ 0.039g, 0.050 ¡¾ 0.026g, and 0.051 ¡¾ 0.017 for RWAT, 0.221 ¡¾ 0.065g, 0.135 ¡¾ 0.053g, and 0.144 ¡¾ 0.038 for IWAT, and 0.079 ¡¾ 0.012g, 0.055 ¡¾ 0.013g, and 0.062 ¡¾ 0.011 for IBAT, respectively). PPAR¥ã protein in the cytosol of EWAT fat pads was analyzed and quantified in comparison to the amount of Glyceraldehyde-3-phosphate dehydrogenase (GAPDH; loading control) present. Mean PPAR¥ã /GAPDH ratios for LFU mice was 0.226 ¡¾ 0.082, for LFO mice was 0.264 ¡¾ 0.122, and for PLU mice was 0.234 ¡¾ 0.108. Mean PPAR¥ã:GAPDH ratios were not significantly different between any of the groups. Conclusion: It appears that the consumption of oxidized oil caused a significant decrease in weight gain and food intake (although not significant) and a significant increase in fat pad mass in mice compared to those consuming a diet with unoxidized oil. The lack of difference in the amount of PPAR¥ã among the three groups of mice suggests that the changes in weight gain and fat pad mass among the oxidized oil consuming animals is not mediated through regulation of PPAR¥ã protein. To our knowledge, ours is the first study to report that mice consuming a low fat diet inclusive of dietary oxidized lipids exhibit greater adiposity than do mice consuming a low fat diet consisting of unoxidized lipids.

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Werner, Tim J. "The effect of high-carbohydrate, low-fat & low-carbohydrate, high protein diets on physiologic and performance variables on row ergometry training." Ohio : Ohio University, 2006. http://www.ohiolink.edu/etd/view.cgi?ohiou1140557597.

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5

Schmidt, Amanda E. "Cut the fat 1% or less campaign /." Online version, 2001. http://www.uwstout.edu/lib/thesis/2001/2001schmidta.pdf.

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6

Triyangkulsri, Warintra. "Factors influencing purchasing decision process of low-carbohydrate products." CSUSB ScholarWorks, 2005. https://scholarworks.lib.csusb.edu/etd-project/2658.

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The purpose of this study was to determine attitudes toward low carbohydrate diets among consumers and the attributes that influence their purchase decision. A growing number of diet trends are spreading across the nation in an effort to improve health and lose weight such as the Atkins diet and the South Beach diet.

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Toma, Kumika. "Effects of High-Carbohydrate and Low-Fat Versus High-Protein and Low-Carbohydrate Diets on High-Intensity Aerobic Exercise." View abstract, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3372362.

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Mitchell, Dorothy T. "The development and pilot testing of a Cholesterol Saturated Fat Index (CSI) scorecard for dietary self-monitoring." Thesis, Virginia Tech, 1993. http://hdl.handle.net/10919/45319.

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The National Cholesterol Education Program Adult Treatment Panel guidelines specify that dietary intervention is the cornerstone of treatment for hypercholesterolemia. Self-monitoring is a strategy used to achieve self-direction in adopting and maintaining a cholesterol-lowering dietary pattern. The Cholesterol Saturated Fat Index (CSI) illustrates the atherogenic potential of food. Given that saturated fat and dietary cholesterol are the two major dietary components known to raise serum cholesterol, a CSI Scorecard was developed and pilot tested as a dietary self-monitoring tool. Twelve nutritionists scored the same five food records with known CSI scores, the reference data. The food records represented CSI scores from the 10th, 25th, 50th, 75th, and 90th percentiles from a pool of 400 usual diet food records. Two-tailed, one-sample t-tests demonstrated that the CSI Scorecard scores were not statistically significant at only the 25th and 75th percentiles. Therefore, in three of five food record percentiles, nutritionists’ CSI scores differed from the corresponding reference CSI scores. Small sample size and years of experience may have been factors influencing the results. Comments from the nutritionists’ critique forms were incorporated into the revision of the CSI Scorecard. Twelve participants scored their four-day food records using the booklet. The Spearman’s rho correlation of the CSI Scorecard derived CSI scores to the reference CSI scores was r_S=.8 (p<.05). These preliminary results and comments from the formative evaluation meetings suggested that the CSI Scorecard deserves further validity testing with a larger sample of subjects. The CSI Scorecard appeared to show promise as a dietary self-monitoring tool that would facilitate increased self-direction in the adoption of a cholesterol-lowering diet.
Master of Science

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9

Ranga, Leocardia. "The association between dietary fat knowledge and consumption of foods rich in fat among first-year students in self-catering residence at a university of technology, Cape Town, South Africa." Thesis, Cape Peninsula University of Technology, 2016. http://hdl.handle.net/20.500.11838/2473.

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Thesis (MTech (Consumer Science: Food and Nutrition))--Cape Peninsula University of Technology, 2016.
Objective: To determine the association between the dietary fat knowledge and consumption of foods rich in fat among first-year students in self-catering residence at a university of technology, Cape Town, South Africa. Design: The two concepts – the dietary fat knowledge (represented by dietary fat food knowledge and dietary fat nutrition knowledge) and the consumption of foods rich in fat – were assessed separately. Two norm-referenced, valid and reliable knowledge tests and an intake screening questionnaire were used for the assessments (as subsidiary objectives), before the associations between the concepts were determined (main objective). The dietary fat food and nutrition knowledge as assessed was categorised in the range poor or below average, average and good or above average, and the consumption of foods rich in fat as high, quite high, the typical Western diet, approaching low or desirable. The Pearson‟s chi-square test was applied to these categorical findings to determine if associations (five percent significance) existed between the concepts. Results: The stratified sample included 225 first-year students. Nearly half (48.4%) of them achieved an average fat food knowledge score, while the majority (80.9%) achieved a poor fat nutrition knowledge score. More than half (52.5%) either followed a typical Western diet, a diet quite high in fat or high in fat. While no significant (p > 0.05) association was found between the students‟ dietary fat food knowledge and consumption of foods rich in fat, significant results were found in the association between the students‟ dietary fat nutrition knowledge and consumption of foods rich in fat (p < 0.05) and between their fat food knowledge and fat nutrition knowledge (p < 0.001). Conclusions: An inverse association was found between the students‟ dietary fat nutrition knowledge and fat consumption, a positive association between their dietary fat food knowledge and dietary fat nutrition knowledge, and no association between their dietary fat food knowledge and fat consumption.

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Crabtree, Christopher David. "Effects of Controlled Hypocaloric Ketogenic and Low-Fat Diets on Liver Fat in Overweight/Obese Adults." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586780375128754.

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Cook, Darci L. "The effect of alterations in diet composition upon anthropometric measures, biochemical parameters, and nutrient intakes in overweight women." Virtual Press, 2005. http://liblink.bsu.edu/uhtbin/catkey/1315182.

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Thirty-seven overweight/obese (BMI: 25-35 kg/m2), premenopausal women that were randomly assigned to either an ad libitum low-carbohydrate (LC) (20% CHO, 30-40% protein, 30-40% fat), or an ad libitum low-fat (LF) (55-60% CHO, 15-20% protein, 20-25% fat) diet.All subjects were given weekly menus matching their assigned macronutrient requirements to aid in meal planning and dietary compliance. Baseline and post-diet measures included height, weight, body composition (DXA), blood lipids [total cholesterol (TC), HDL, LDL, and triglycerides (TG)], and plasma insulin levels. There were no significant group differences in any of the above-listed variables prior to the study. Nineteen women completed the 6-wk study (LC=11, LF=8). Compliance to the diets was adequate as indicated by weekly 24-hr recalls and daily urinary ketone levels. Both groups lost a significant amount of weight and body flat, (P<0.05); and weight and body fat losses were not significantly different between the groups. All groups experienced similar decreases in TG, TC, LDL, HDL, and insulin levels. These results indicate a LC diet is no more effective than a LF diet in promoting favorable changes in body weight, body composition, blood lipids and insulin levels.
Department of Family and Consumer Sciences

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12

Barnes, Dawn M. "The effects of a low-fat diet compared to a ketogenic diet on resting metabolic rate and body composition." Virtual Press, 2002. http://liblink.bsu.edu/uhtbin/catkey/1233191.

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The Cerulean Warbler (Dendroica cerulea) is state-listed as threatened or as a species of special concern throughout most of its range, suffering from extensive loss of breeding habitat. Although the Cerulean Warbler has been classified as a species of high conservation concern, little is known about its life history. Conservation and management efforts directed toward protecting forested landscapes on the breeding and non-breeding grounds, with the specific habitat requirements that this species prefers, are paramount. Yet, there is little specific quantitative data in existence regarding the pertinent vegetation structure in which the Cerulean Warbler can successfully breed. During the two field seasons of this project (2000 and 2001), sixty-two territories were located, monitored, and mapped during the nesting season. To determine the habitat selection of Cerulean Warblers, twenty-seven habitat variables were measured within the center of mapped territories and random sites (0.04 ha circle). The size of territories (n = 59) ranged from 0.036 ha to 1.427 ha. The number of large trees (> 38 cm DBH) was significantly higher in territories, as was the total density of all trees than in random sites. Vertical stratification between 0 - < 2 m was also significantly higher in territories than in random sites. Territories were located significantly closer to water bodies, roads, and agricultural fields. The relative abundance of Cerulean Warblers differed greatly among study sites (O/km2-3.86/k m2). In all study sites containing at least two birds throughout the breeding season, territories exhibited a significantly clumped distribution. As expected, canopy gaps were present in all territories, and perch trees were significantly larger than average trees available to males within territories. This species was located almost exclusively along ridgetops and mesic slopes. The greatest number of birds occurred in study sites that were located within state forests that are currently being managed for timber harvest versus national forest.
School of Physical Education

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13

Kist, William B. "The effect of a brief period of low-fat and low-carbohydrate diet on postprandial lipemia, caloric intake, and mood in normal weight and overweight/obese premenopausal women /." free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3074416.

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14

Middleton, Olivia Lane. "A Low-Fat Diet Containing Heated Soybean Oil Promotes Hyperglycemia in C57BL/6J Mice." Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/nutrition_theses/49.

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A Low-fat Diet Containing Heated Soybean Oil Promotes Hyperglycemia in C57BL/6J Mice Introduction: The metabolic effects of consuming mildly oxidized lipids as compared to highly oxidized lipids are not well documented. Consumption of highly oxidized polyunsaturated fatty acids, even in a low-fat diet, may be a threat to one’s health. Previous studies in our lab have shown that mice consuming soybean oil heated for 3 hours, compared to unheated, gain less body weight, but more fat pad mass, and 3T3-L1 adipocytes treated with soybean oil heated for ≥ 6 hours have abrogated triglyceride accumulation. Another study showed that rats fed highly oxidized oil (heated > 24 hrs), as compared to fresh soybean oil and fish oil, had lower fat pad mass and weight gain but developed glucose intolerance. This suggested that the extent of lipid oxidation determined the subsequent metabolic risk. Objective: Our aim, in the current study, is to investigate if a low-fat diet with soybean oil heated for increasing time points (3h, 6h and 9h) alter fat mass and glucose tolerance. Methods: Six week old, male, C57BL/6J mice were randomly divided into six groups (n=8/group). Three groups were fed a low fat diet with soybean oil heated for 3 (3hr-HO), 6 (6hr-HO), or 9 (9hr-HO) hours for 16 weeks. Another three groups were pair-fed to each of the 3hr-HO, 6hr-HO and 9hr-HO groups with a low-fat diet containing unheated oil (PF-UHO). Food consumption was recorded every 3-4 days, and body weights were recorded weekly. Soy oil in the diets was analyzed for products of oxidation. At 16 weeks, blood glucose levels were measured after a 6 hour fast; fat pad and liver weights were recorded, and blood was collected by cardiac puncture for serum insulin analysis. Results: Final weight gain was not significantly different between all HO groups as a percent of their respective PF groups (p >0.05). The feeding efficiency for 3hr, 6hr, and 9hr-HO groups as a percent of PF was 92.75, 113.02, and 111.28, respectively. Mean weights of all fat pads for HO groups decreased with heating time as a percent of PF, although these differences were not statistically significant. Blood glucose was lowest in the 3hr-HO group and significantly increased from 3hr-HO group to 6hr-HO group (p=0.021) as a percent of PF. Serum insulin levels decreased for the HO groups as heating time increased, although these differences were not statistically significant. Conclusion: Consuming a diet with increasing amounts of oxidized lipids decreased fat pad mass and insulin levels, while increasing fasting glucose levels. This paradoxical relationship between increased glucose in the presence of decreased insulin in c57BL/6J mice could be due to either reduced insulin secretion or increased insulin resistance. Further research in our lab will aim to analyze triglyceride accumulation in the liver and muscle cells of these mice to determine if oxidized lipids promote ectopic fat deposition.

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Werner, Tim. "The Effect of High-Carbohydrate, Low-Fat & Low-Carbohydrate, High Protein Diets on Physiologic and Performance Variables on Row Ergometry Training." Ohio University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1140557597.

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White, Jennifer. "Training in acquisition of texture-cued fasting-anticipatory satiety in rats using high- or low-fat diets." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20551.

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Anticipatory satiety is the ability to reduce meal size when the diet at that meal is consistently followed by a short time interval to the next access to food. This prediction of intake is learnt, i.e. based on the association of a food's sensory characteristics with some consequence(s) of ingesting it.
Two pilot studies were conducted using male Sprague-Dawley rats in which (1) the ability of food texture to cue fasting duration was indicated by evidence of anticipatory satiety in the low-fat powder-long/paste-short group and in the high-fat paste-long/powder-short group and (2) the pattern of anticipatory satiety was seen only in the low-fat granules-long/powder-short group.
In the main experiment (n = 9), anticipatory satiety was reached twice in the highfat powder-long/pellet-short group on days 16--23 (p ≤ 0.1) and once in the low-fat pellet-long group/powder-short on days 20--23 (p ≤ 0.1). The acquisition of texture-cued fasting-anticipatory satiety seems to depend upon high-energy density of the diet and the utilisation of textures which make it easier for the rats to eat.

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Entwistle, Timothy. "Implementing a healthy eating strategy after heart and lung transplantation : a randomised controlled feasibility study." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/implementing-a-healthy-eating-strategy-after-heart-and-lung-transplantationa-randomised-controlled-feasibility-study(b38c6367-3be9-4fb0-91a2-43f9b981b9a8).html.

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Background: Studies evaluating the possible health-promoting effects of sound nutrition in heart and lung transplant recipients are currently lacking. Despite advances in drug treatment and patient monitoring, lifestyle-associated complications such as obesity, diabetes and cardiovascular disease occur frequently. Following transplantation, a low-fat eating pattern is currently viewed as best standard care. However, a Mediterranean diet based on a varied range of fresh unprocessed foods and supplemented with extra virgin olive oil has demonstrated clinical benefit in various non-transplant populations. The aim of this study was to evaluate the feasibility and acceptability of a Mediterranean vs a low-fat diet intervention in heart and lung transplant recipients, and to assess clinical and biochemical outcomes. Methods: This was a randomised controlled feasibility trial to evaluate a Mediterranean diet supplemented with extra-virgin olive oil, vs a modified low-fat diet in heart and lung transplant recipients at a single centre. In total, 41 clinically stable male and female (median age 55 years) transplant recipients were randomly assigned (1:1) in two separate 12-month waves (n=24 and n=17) to one of these diet interventions. A range of validated food frequency and adherence questionnaires captured changes in participants' reported eating habits to 6 weeks post-study. Clinical and biochemical analysis was conducted at baseline, 25 and 52 weeks. Telephone and outpatient contact provided a support mechanism to reinforce dietary behavioural change. Caloric intake and physical exercise awareness were discussed, but not promoted. Results: Thirty nine participants completed the trial (95%). Adherence to both interventions improved significantly at week 25, and was maintained at 52 and 58 weeks. Compared with baseline, waist circumference decreased in both groups at week 25 (p=0.024). A decrease in blood pressure and heart rate occurred at 52 weeks in the low-fat group only. At 52 weeks, higher adherence resulted in significant improvements in fasting glucose in the Mediterranean (< 4.8%) and low-fat (< 5%) groups. This respective pattern was also observed with total cholesterol (≤ 9% and ≤ 7%), triglycerides (≤ 9% and ≤ 20%) and IGF-1 (≤ 9% and ≤ 15%). A significant decrease in the LDL/HDL ratio (≤ 12%) occurred in the Mediterranean group only. Moreover, clinically relevant lipid and glucose regulation changes were observed in each intervention. Conclusions: The implementation of a prospective 12-month Mediterranean or low-fat diet is feasible and acceptable in a heart and lung transplant outpatient setting. Both interventions were positively associated with improvements in lipid and blood glucose regulation and circulating IGF-1. As part of a multidisciplinary framework, these findings offer an additional therapeutic strategy to optimise outpatient care.

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Kemp, Christopher James. "Plasma Levels of Brain-Derived Neurotrophic Factor in Obese Women Randomly Assigned to a Very Low-Carbohydrate Diet Or an Energy-Restricted Low-Fat Diet." Cincinnati, Ohio : University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc//view?acc_num=ucin1175255390.

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Thesis (M.S.)--University of Cincinnati, 2007.
Advisor: Dr. Kim N. Dietrich . Title from electronic thesis title page (viewed May 30, 2010). Includes abstract. Keywords: BDNF; Hypothalamus; Obesity; Weight loss. Includes bibliographical references.

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Riggs, Amy Jo Gropper Sareen Annora Stepnick. "Changes in energy expenditure associated with injestion of high protein, high fat versus high protein, low fat meals among underweight, normal weight, and overweight females." Auburn, Ala., 2006. http://repo.lib.auburn.edu/2006%20Spring/doctoral/RIGGS_AMY_28.pdf.

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Blocher, Lisa M. "An educational program approach to weight loss in the abdominally obese emphasizing low dietary fat intake." Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/865940.

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The composition of the diet has been recently researched as an important factor in controlling excess body fat, and thus obesity. Along with dietary modifications, it has been stressed to incorporate behavior modification and daily physical activity to promote weight loss. A comprehensive program incorporating all three components is the suggested treatment for long term weight maintenance. This study investigated a 12 week low dietary fat education program including behavior modification and physical activity to promote weight loss in the abdominally obese. There were eight experimental subjects and four controls. Measurements assessed were height, weight, percent body fat, body mass index, waist/hip ratio, ideal body weight, daily caloric intake, percent dietary fat intake, percent saturated fat intake, saturated fat gram intake, physical activity assessments and resting metabolic rate. Results showed significant differences between the experimental and control groups for calorie intake, body weight, ideal body weight and saturated fat gram intake at post-intervention. Percent of dietary fat intake decreased from baseline to follow-up in the experimental group, but did not reach significance. There was a 33% decrease in saturated fat gram intake from baseline to follow-up in the experimental group. A significant decrease in daily caloric intake occurred in the experimental group from baseline to post-intervention. The decrease in body weight could not be directly correlated to dietary fat intake, although they did have a tendency to move in the same direction. These data suggest the weight management program in this study was successful at decreasing body weight, daily caloric intake, dietary fat intake and saturated fat intake.The qualitative interview revealed obstacles faced by the subjects. The most common difficulties in adhering to the program included time constraints, travel, lack of a structured physical activity component, social pressures triggering eating behavior, feeling of guilt when prioritizing time for oneself and lack of continued support and education through class sessions. Individual motivational factors existed. Therefore, personalized attention and a continued support system would be beneficial as part of the treatment program for success in changing lifestyle behaviors.In conclusion, this data suggest an educational program encouraging decreased dietary fat intake, behavior modification and increased daily physical activity without a calorie controlled plan can promote weight management in the abdominally obese.
Institute for Wellness

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Wright, Colleen R. "Social barriers to the maintenance of a very low fat cardiac diet, a qualitative study." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1995. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq23774.pdf.

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22

Kudlas, Jane Michele. "Low-fat diet vs. education support in the treatment of late luteal phase dysphoric disorder." Diss., Virginia Tech, 1992. http://hdl.handle.net/10919/39719.

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A treatment outcome study was conducted comparing a low-fat diet intervention with an education-support group and a waiting-list control group in the treatment of premenstrual tension syndrome (PMS) or Late Luteal Phase Dysphoric Disorder (LLPDD). Subjects met provisional diagnostic criteria for LLPDD and symptoms were monitored prospectively. A low-fat diet was hypothesized too be an effective intervention for reducing the severity of both physical and emotional symptoms in women suffering from LLPDD. This was based on the theory relating raised estrogen levels to premenstrual distress, and research suggesting low-fat diets reduce estrogen levels. The hypothesis that a low-fat diet would decrease premenstrual suffering was not supported by the results of this study. However, there appeared to be an advantage to participating in a group which provided support and information on LLPDD compared to receiving no treatment. Implications for future research, treatment recommendations, and methodological issues are discussed.
Ph. D.

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23

Bye, Asta. "Low fat, low lactose diet used as prophylactic treatment of acute intestinal reactions during pelvic radiotherapy. A prospective randomised study." Doctoral thesis, Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, 2002. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-36.

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Purpose. The main aim of the present study was to evaluate the effect of a low fat, low lactose diet on acute and late gastrointestinal side effects of pelvic radiotherapy. We also wanted to evaluate if such a treatment would influence the patients health related quality of life (HRQOL) in any way.

Background. Cancer therapies and their side effects may cause nutritional problems and malnutrition. Pelvic radiotherapy, a common treatment modality for patients with carcinoma of the endometrium or cervix, is associated with both acute and late side effects that may affect nutritional status. Acute injury may lead to impaired absorption of nutrients and fluid. The patients experience diarrhoea, weight loss, nausea and vomiting. Bile salt malabsorption may be a factor in the pathogenesis of the diarrhoea. In cases of bile salt malabsorption a low fat diet will cause decreased bile salt excretion and thereby relief of symptoms. This assumption was evaluated in a small, non-randomised study in 1985. The results indicated that a low fat diet may reduce the frequency of diarrhoea and use of anti-diarrhoeal agents during radiotherapy. These findings were regarded as promising and since nutrition management guidelines for radiation enteritis were lacking in the literature, a clinical trial was planned.

Methods. The study was designed as an open randomised clinical trial and conducted at the Norwegian Radium Hospital (NRH). The intervention diet (low fat, low lactose) was to be followed during and six weeks after radiotherapy. Measurements were performed at basement, the 3rd and last week of radiotherapy, six week after and then every 8th week. The entire period was one year. In November 1993 the surviving patients were approached again and asked to complete a questionnaire package similar to the one completed during the clinical trial. The study population was recruited from the department of gynaecology at NRH. The main selection criteria were pelvic radiotherapy (dose above 40 Gy) age = 75 years and a WHO functional status = 2. Patients were consecutive included from May 1988 through May 1990 and 143 women were included. Seventy-one were assigned to the intervention diet and 72 to the control group. In November 1993, 94 women were alive without any known relapse and 79 (84%) accepted participation. The women registered use of Loperamid and the daily number and consistency of bowel movements. The data on bowel movements was categorised and used to evaluate if diarrhoea was present or not. Nutritional status was evaluated by the means of weight development, arm muscle circumference (AMC), serum transferring (STF) and serum albumin (s-Alb). Dietary intake was assessed by 48-hour recall prior to radiotherapy, 4-days unweighed dietary record during radiotherapy and 7-days weighed dietary records during follow-up. 24-hour urinary nitrogen was used to validate the food records. HRQOL was defined as the patients' self-reported subjective physical and psychosocial situation as a consequence of disease and treatment. It was measured with the EORTC Core Quality of Life Questionnaire 36-item version (EORTC QLQ-C36).

Results. During the last week of radiotherapy 14 patients (23%) in the intervention group and 32 (48%) in the control group reported diarrhoea (p< 0.01). The intervention group also used less anti-diarrhoea medication than the control group, 0.6 tablets per day versus 1.1 (p<0.01). Six weeks after end of radiotherapy, no group differences were found with regard to bowel movements or medication. The intervention group had a lower energy intake than the control group during radiotherapy, 5.7 MJ versus 6.5 MJ (p<0.05). The mean daily fat intake was respectively 34.3 g and 60.1 g (p<0.001). The intervention group received a significant lower part of the energy from milk products, meats, fats and sugar than the control group, and consumed more energy from vegetables and fruits, cereals and fish. Weight loss was more pronounced in the intervention group (mean reduction of 2.6 kg versus 1.7 kg) than in the control group (ns) during treatment. Mean values of AMC, s-Alb and STF were within the reference range in both groups during the entire observation period. During the last week of radiotherapy six patients (9%) in the intervention group and 4 (6%) in the control group were mildly depleted (ns). At 12 weeks and after one year none of the patients could be categorised as malnourished. No major differences in HRQOL were found between the two groups during radiotherapy and one-year follow up. Within the control group an association between diarrhoea and deteriorated role functioning, physical functioning and fatigue was found during the last week of radiotherapy that was not found in the intervention group. Regarding late effects of radiotherapy (3-4 years after radiotherapy) both groups had more diarrhoea than in the general population, 23.8 versus 9.5 (p<0.01). There was however a tendency to more pronounced diarrhoea in the control group (29.6 (SD=27.3)) than in the intervention group (19.4 (SD=25.4)) though not statistical significant. Substantial diarrhoea was associated deteriorated SF and fatigue.

Conclusions. The intervention group had less diarrhoea and used less Loperamide during radiotherapy than the control group. This finding did not affect nutritional status since no differences in nutritional status were found between the two groups. Both groups had a reduced energy intake and weight loss during radiotherapy. In the control group diarrhoea increased fatigue and had negative effects on physical functioning and role functioning. The intervention did not lead to differences in late radiation injury and chronic diarrhoea 3-4 years after treatment but diarrhoea was most prominent in the control group. Diarrhoea as a late effect increased fatigue and had a negative influence on social well being.

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Murphy, Tamzyn. "Diet composition and perceptions around food in individuals with Type 2 Diabetes Mellitus following a long-term low carbohydrate high fat diet." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31053.

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Background: Type II diabetes mellitus (T2D) is described as a progressive metabolic disease, characterised by disrupted glycaemic regulation, and is associated with high rates of morbidity and mortality. Low carbohydrate high fat (LCHF) diets may be particularly effective and sustainable for the treatment of T2D and have become a popular ‘self-therapy’. This study investigates the real-world dietary composition and potential effects of a long-term LCHF diet on T2D. Materials and Methods: A multi-method descriptive study investigating the diet and related aspects in 28 adult T2D patients perceiving to follow an LCHF diet for ≥ 6 months. Data collection included a quantitative phase (general detailed health and a food frequency (FFQ) questionnaires, 24-hour diet recall (24HR), 3-day food record, anthropometry, blood pressure, blood sampling, past medical records) and a qualitative phase (semi-structured interviews). Results: LCHF (duration 2.1 ± 1.5 y) consisted of 67% fat (143.2 ± 67.9 g, mainly saturated fat from added fat, eggs, meat, poultry, seafood and full cream dairy), 10% carbohydrate (64.0 ± 27.9 g, primarily from full cream dairy, nuts and seeds), 20 % protein (96.0 ± 37.4 g, primarily animal origin) and 3% alcohol (primarily wine). Cholesterol intake (616.3 (402.8–804.2) mg) was higher, and fibre (14.7 ± 7.5 g), calcium and folate lower than recommendations. Added sugar (0.5% of energy intake) and processed foods were seldom consumed. Daily energy intake was 1946.3 ± 807.2 kcal (436.7 ± 728.3 kcal. d-1 calculated energy deficit). Intermittent fasting (≥ 16 h. d-1) was followed by 61% of the group. From pre-LCHF to the time of the study, reductions were seen in obesity prevalence (- 50 %), body weight (- 16.9 ± 11.7 %), HbA1c concentration (- 2.45 ± 2.59 %) and T2D prevalence (36 % were no longer classified as T2D based on HbA1c and T2D pharmacotherapy). Non-pharmacologically-induced changes in HbA1c concentrations showed HbA1c reductions in 75 % of the group during the time on LCHF. LCHF was generally reported as sustainable, linked to reduced hunger and cravings and improvements in overall health and health-related quality of life (HRQoL). Challenges included constipation, initial adaptation and social difficulties related to LCHF. Discussion and conclusion: These findings are the first to describe the nature and composition of a self-selected ad libitum real-world LCHF diet and coexisting health parameters. LCHF can be sustainable in T2D patients and may be linked to improvements in glycaemic control, medication reduction, hunger, health and HRQoL.

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Wagner, Jana Louise. "Promoting one low-fat, high-fiber choice in a fast-food restaurant: use of point-of-purchase prompts." Thesis, Virginia Polytechnic Institute and State University, 1987. http://hdl.handle.net/10919/80169.

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This research project investigated a method to promote one low-fat, high-fiber choice in a national chain fast-food restaurant. It is an extension of efforts toward large-scale dietary change. A procedural extension of a prompting strategy was used in an attempt to influence customers to choose a salad. A simple visual and print message based on themes derived from formative and pilot research at the restaurant was presented during two intervention phases of a reversal design. The message, "Be Fit and Healthy; Eat a Low-fat SALAD as Your Meal or Add a Side Salad," was displayed in colorful posters and tent cards which were placed on all the tables. Data from a comparison base in a neighboring town were obtained. A one-month follow-up phase was included in the design. Prices and in-store advertisements were identical in both locations. The existing computerized cash register system was used to obtain accurate, objective data. Daily and weekly sales percentages of several entrees were obtained. Results of analysis using a correction procedure indicate that when graphically represented, salad sales across phases increased with the introduction of the prompts, and decreased with their removal. In addition, three entrees not represented by associated prompts remained stable across phases. For Salads-combined, results indicate that sales increased about 15% and 9%, respectively, for the first and second intervention phases. Daily temperature during this project was variable. Although a comparison site was used to control for the effects of weather, results indicate that salad prompting may have increased sales more during warmer temperature. Population demographics were recorded. Analyses of the customer population during this project indicate customers were about equal by gender, and consisted primarily of white, 18-39 years old individuals. The cost for each added salad bought during the intervention was about $.22, and the cost to raise the percent of salad sales, each percent, across the four weeks was about $16.00. Future research should attempt to foster longer term behavior change and integrate multifaceted promotions.
Master of Science

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26

Lidgren, Agnetha. "Högfettskost till obesa barn : Pilotstudie." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-132431.

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Syftet med denna pilotstudie var att studera om man hos pediatriska patienter som lider av sjuklig fetma kan se förändringar i metabolismen genom att ersätta den traditionella kosten med en kost bestående av hög andel fett och låg andel kolhydrater. De frågeställningar som används är om den förändrade kosten leder till en gynnsam förändring av metabola markörer samt hur patientupplevelsen av de nya kostråden är. Studien har både en kvantitativ och kvalitativ design. Totalt ingår 4 barn i åldern 4-17 år. Två av dessa har under fyra veckor ätit en kost bestående av hög andel fett (50-60E%) och låg andel kolhydrater (15-20E%). Efter avslutad intervention undersöktes hur metabola parametrar förändrats (blodprov) samt hur patienterna upplevt kosten (frågeformulär). Resultatet visar på att kostråden leder till en sänkning av triglycerider, glukos, HDL, total kolesterol och ASAT. Bland kontrollpatienterna ser man en ökning av triglycerider, HDL och total kolesterol. Upplevelsen av kostråden beskrivs som positiva, trots att nackdelar finns. Det finns en positiv attityd till att fortsätta med kostråden.

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Meuser, Ashley R. "Changes in Social Cognitive Theory Constructs Influence Changes in Consumption of Fruits, Vegetables, Low-Fat Dairy Products, and High Fat/High Sodium Foods in Adolescents with Hypertension." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282167496.

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Beijer, Emelie, and Renate Cerljen. "LCHF - Low Carb High Fat : en experimentell studie av 3 veckors LCHF-kost på hälsomarkörer hos normalviktiga kvinnor." Thesis, Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-1783.

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Sammanfattning Syfte och frågeställningar Syftet med denna uppsats var att undersöka hurvida en LCHF (Low Carb High Fat) kost skulle kunna vara en hälsosam livsstil utifrån hur den påverkar olika hälsomarkörer hos normalviktiga personer där en viktminskning ej har eftersträvats. Frågeställningen var följande: Hur påverkar en LCHF-kost med maximalt 30 gram kolhydrater per dag under 3 veckor normalviktiga kvinnors BMR (Basal Metabolic Rate), blodlipider, blodglukos, blodtryck, kroppssammansättning, midje- och höftmått samt deras kroppsvikt? Metod En experimentell studie har genomförts på 8 normalviktiga kvinnor mellan 20 och 35 år. Samtliga försökspersoners BMR, blodlipider, blodglukos, blodtryck, kroppssammansättning, midje- och höftmått samt kroppsvikt mättes vid normala levnadsförhållanden innan studiens start samt efter 3 veckor av en strikt LCHF-kost med endast 30 gram kolhydrater per dag. Resultat BMR sänktes i genomsnitt med 4,4% vilket var signifikant (P<0,05). HDL (High-density lipoproteins), LDL (Low-density lipoproteins) samt totalkolesterol höjdes signifikant (P<0,01) med 21%, 25% respektive 22%. Ingen signifikant skillnad i LDL/HDL-kvot, triglycerider eller blodtryck erhölls. Blodglukos sänktes med 12%, skillnaden var dock ej signifikant. Andel kroppsfett sänktes signifikant med 8,7% (P<0,01) och fettmassan med 11% (P<0,01). Den fettfria massan visade ingen signifikant skillnad. Midjemåttet minskade signifikant med 2,3% (P<0,05) och kroppsvikten i genomsnittt med 1,24 kg (P<0,05). Höftmåttet visade ingen signifikant skillnad mellan mätningen före och efter 3 veckors LCHF-kost. Slutsats Studiens resultat tyder på övervägande negativa effekter av 3 veckors LCHF-kost på olika hälsomarkörer, vilket skulle kunna få allvarliga följder så som kardiovaskulära sjukdomar och depression förutsatt att verkan successivt ökar.
Abstract Aim The aim of this study is to examine if LCHF (Low Carb High Fat) could be a healthy lifestyle based on how it affects various health markers in normal weight people where weight loss has not been pursued. Specific question: How does intake of a LCHF diet with a maximum of 30 grams of carbohydrates per day during 3 weeks affect normal-weight women´s BMR, blood lipids, blood glucose, blood pressure, body composition, waist and hip dimensions and body weight? Method An experimental study was performed on 8 normal-weight women aged 20 to 35 years old. All subject´s BMR, blood lipids, blood glucose, blood pressure, body composition, waist and hip dimensions and body weight were measured at normal living conditions before the study began. Each subject was put on a strict 3 week Low Carb High Fat diet consisting of only 30 grams of carbohydrates per day. Results BMR was reduced by an average of 4,4% which was significant (P<0,05). HDL, LDL and total cholesterol were increased significantly (P<0,01) by 21, 25 and 22%, respectively. There were no significant differences in LDL/HDL ratio, triglycerides or blood pressure. Blood glucose concentration was reduced by an average of 12%, however the reduction was not statistically significant. Percentage body fat was significantly lowered with 8,7% (P<0,01) and fat mass with 11% (P<0,01). The fat free mass showed no significant difference between pre- and post-tests. The waist circumference was significantly decreased by 2,3% (P<0,05) and average body weight of 1,24 kg (P<0,05). The hip dimension showed no significant difference between pre- and post-tests. Conclusion The results of this study indicate negative effects on the blood lipid profile after 3 weeks of LCHF diet, which could lead to serious consequences such as cardiovascular disease and depression provided that the effect is progressively enhanced.

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Ollberding, Nicholas Jay. "Changes in Food Sources of Fat, Cholesterol, and Protein in the Diets of Adolescents with Hypertension in Response to a Dietary Intervention Focusing on Fruits, Vegetables, and Low-fat Dairy Foods." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211902693.

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30

Alhindi, Yosra. "Effects of low citrate synthase activity on physiological responses of mice to high fat diet and palmitate induced lipotoxicity." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231391.

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The main aim of this thesis was to examine the hypothesis that the A/J strain variant of H55N substitution affects citrate synthase (CS) enzyme activity and metabolic health in mice fed a high fat diet (HFD). C57BL/6J (B6) mice and congenic B6.A-(rs3676616-D10Utsw1)/KjnB6 (B6.A) mice, a strain which carries the A/J allele of Cs on the B6 strain background, were fed a HFD (45% kcal from fat) for 12 weeks. CS activity, but not that of ß-hydroxyacyl-coenzyme dehydrogenase was lower in the gastrocnemius muscle of B6.A mice compared to B6 mice (P< 0.001). During HFD feeding the glucose tolerance of mice decreased progressively and to a greater extent in B6.A females compared to B6 females, with males showing a similar trend. Interestingly, after 12 weeks of HFD feeding only B6.A males showed increases (P< 0.05) in their resting metabolic rate; moreover; core body temperature were also increased (P< 0.05) for congenic B6.A of both sexes by the end of the study. However, body weight and fat gain did not differ between B6.A and B6 mice. The second aim of the thesis was to test the hypothesis that low CS activity promotes palmitate-induced lipotoxicity in muscle cells. After 18 hours of incubation in 0.8 mM palmitate, C2C12 muscle cells with a ~50% reduction in CS activity showed low (P< 0.001) viability, increased (P< 0.001) levels of cleaved Caspase-3, high levels of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation (P< 0.05), low levels of protein kinase B phosphorylation, high mitogen-activated protein kinases activation (P< 0.001) compared to the control shRNA cells. This was coupled with higher levels of mitochondrial proteins (P< 0.05), which are involved in oxidative phosphorylation. C2C12 cells with reduced CS activity also showed high reactive oxygen species production (P< 0.05), low intracellular ATP levels (P< 0.05), and lower basal mitochondrial respiration (P< 0.001). In summary, the A/J strain variant of H55N is associated with low CS enzyme activity and impaired metabolic health when fed HFD. Palmitate has a lipotoxic effect on Cs shRNA transfected cells and can lead to cell death.

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Moore, Rebecca. "The relationship between a dietary pattern high in fruits, vegetables, low fat dairy, and whole grains and low in red meat and vascular structure and function in individuals with type 2 diabetes." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439307990.

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32

Naples, Scott Thyfault John P. "Metabolic responses to a high fat diet in skeletal muscle of rats bred for high or low endurance running capacities." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/6585.

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The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on November 19, 2009). Thesis advisor: Dr. Thyfault. Includes bibliographical references.

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Rodrigues, Manuela Ortega Marques. "Efeitos da perda de peso corporal induzida por dieta hipolip?dica ad libitum e pela restri??o cal?rica com dieta hiperlip?dica na inflama??o do tecido adiposo de camundongos obesos." UFVJM, 2017. http://acervo.ufvjm.edu.br/jspui/handle/1/1614.

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Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq)
Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)
Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais (FAPEMIG)
A expans?o do tecido adiposo branco na obesidade leva ? express?o alterada de prote?nas em seus adip?citos, bem como a infiltra??o de c?lulas do sistema imune, especialmente macr?fagos, cujas secre??es levam ao desenvolvimento da inflama??o cr?nica de baixo grau, a qual ? considerada subjacente ao desenvolvimento de in?meras comorbidades. Dentre as formas de tratamento da obesidade, dietas de restri??o cal?rica (RC) nutricionalmente balanceadas induzem a perda de peso e melhorias em marcadores sist?micos da inflama??o, mas os efeitos diretos no tecido adiposo visceral ainda s?o controversos. No entanto, existe uma lacuna sobre qual o impacto dessas dietas na inflama??o local, mesmo em condi??es de sobrecarga lip?dica. Assim, o objetivo deste estudo foi avaliar os efeitos da perda de peso corporal induzida por dieta hipolip?dica ad libitum e pela restri??o cal?rica com dieta hiperlip?dica na inflama??o do tecido adiposo visceral de camundongos obesos. Para tal, inicialmente, camundongos C57BL/6 com 12 semanas de idade, machos, foram divididos em dois grupos: LF ? alimentados com dieta controle hipolip?dica ? do ingl?s low fat (10% das calorias, fonte ?leo de soja, rica em ?cidos graxos poli-insaturados); e HF ? alimentados com dieta controle hiperlip?dica ? do ingl?s high fat (60% calorias, fonte banha de porco, rica em ?cidos graxos saturados) para indu??o da obesidade. Ap?s oito semanas, seis animais de cada grupo foram eutanasiados para verifica??o da adiposidade visceral e estado inflamat?rio (dosagens de prote?na C reativa ? PCR s?rica e hep?tica). Em seguida, os animais HF foram aleatoriamente divididos em tr?s grupos HF ? continuaram recebendo dieta HF; LFAL ? submetidos ao emagrecimento pela substitui??o da dieta HF pela LF e acesso livre (ad libitum) e RHF ? submetidos ao emagrecimento por receberem quantidades restritas em calorias da dieta HF para atingir o mesmo peso corporal dos animais LFAL. A partir deste momento, esses grupos foram alimentados, juntamente com os animais LF, por mais sete semanas. Ao final, foram avaliados o ganho/perda de peso corporal, a adiposidade, as concentra??es s?ricas e hep?ticas de PCR, e as concentra??es de leptina, adiponectina, e das citocinas IL-6, TNF e MCP-1 no tecido adiposo retroperitoneal, al?m da morfologia dos adip?citos e a presen?a de infiltrados inflamat?rios no tecido adiposo retroperitoneal. Ao final da fase de indu??o da obesidade, os animais HF estavam obesos e inflamados. Ao final da fase de indu??o da perda de peso, os grupos LFAL e RHF tiveram pesos corporais semelhantes, menores que o HF e se igualaram ao LF. No entanto, houve maior dificuldade em perder peso pelo grupo RHF em compara??o ao LFAL, dado pelas diferen?as significativas entre os deltas de perda de peso, que foram menores para RHF e pelos coeficientes de efici?ncia energ?tica, que foram maiores para o grupo RHF. Os animais LFAL retornaram a adiposidade e a hipertrofia dos adip?citos viscerais a valores semelhantes ao grupo LF. Isto provavelmente foi o que levou ? menor concentra??o de leptina com concomitante aumento da adiponectina e menor infiltra??o de c?lulas inflamat?rias neste tecido, igualando-se tamb?m ao LF. Em consequ?ncia, houve menor concentra??o tecidual de citocinas pr?-inflamat?rias, al?m de menor concentra??o hep?tica e circulante de PCR. J? para os animais RHF, houve apenas atenua??o da adiposidade e da hipertrofia dos adip?citos retroperitoneais. Isso foi suficiente para restabelecer a concentra??o local de leptina a n?veis semelhantes ao grupo LF, embora n?o tenha elevado a concentra??o de adiponectina. Al?m disso, a infiltra??o de c?lulas inflamat?rias menteve-se tamb?m elevada. N?o houve redu??o da concentra??o de citocinas pr?-inflamat?rias, ? exce??o da IL-6, que reduziu levemente. A concentra??o hep?tica de PCR foi atenuada, o que n?o refletiu na concentra??o s?rica dessa prote?na. Concluiu-se que a restri??o cal?rica com dieta hiperlip?dica foi menos eficiente em promover a perda de peso e de adiposidade e n?o melhorou a inflama??o do tecido adiposo visceral, comparada com a dieta hipolip?dica ad libitum. Inferiuse que a ingest?o de dieta com sobrecarga de lip?deos (60% das calorias) e de ?cidos graxos saturados foi mais determinante da inflama??o local do que a restri??o cal?rica per se.
Disserta??o (Mestrado) ? Programa Multic?ntrico de P?s-gradua??o em Ci?ncias Fisiol?gicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2017.
The expansion of white adipose tissue in obesity leads to altered protein expression in its adipocytes, as well as the infiltration of immune cells, especially macrophages, whose secretions lead to the development of chronic low-grade inflammation, which underlies the development of several comorbidities. Among treatments, caloric restriction (CR) nutritionally balanced diets induce weight loss and ameliorates inflammation systemic markers, but adipose tissue effects are still controversial. Moreover, there is a gap on the impact of these diets on local inflammation, even under lipid overload. Thus, the aim of this study was to evaluate effects of body weight loss induced by a low fat ad libitum diet and a CR in a high fat diet in the visceral adipose tissue inflammation of obese mice. Firstly, 12 weeks of age male C57BL/6 mice were divided into two groups: LF - fed a control low fat diet (10% calories, source soybean oil, high in polyunsaturated fatty acids); and HF - fed a control high fat diet (60% calories, source lard, high in saturated fatty acids) for obesity induction. After eight weeks, six animals from each group were euthanized to verify visceral adiposity and inflammatory status (serum and hepatic C-reactive protein-CRP). Then, HF animals were randomly divided into three groups: HF ? keept at HF diet; LFAL - a weight loss group that was switched from HF to LF and maintained on it ad libitum; RHF - a weight loss group that received restricted amounts of HF to maintain the same body weight as LFAL. Thereafter, these groups were fed, along with the LF animals, for another seven weeks. At end, body weight gain / loss, adiposity, serum and hepatic CRP concentrations, and adipose retroperitoneal tissue concentrations of leptin, adiponectin, IL-6, TNF and MCP-1 were evaluated, as well as adypocite morphology and the presence of inflammatory infiltrates in the retroperitoneal adipose tissue. Obesity was induced, since HF animals had higher weights, adiposity and were inflamed. At the end of the weight loss period, both LFAL and RHF had similar body weight, lower than HF and equal to LF. However, it was more dificcult to loose wheight by the RHF group compared to LFAL, since weight loss deltas were lower for RHF and energy efficiency ratios were higher for RHF group. LFAL animals returned visceral adiposity and retroperitoneal adipocyte hypertrophy similarly to the LF group. Also, there was a lower leptin level with concomitant increase of adiponectin and less infiltration of inflammatory cells in this tissue, also matching to LF. Still, there was a lower tissue concentration of proinflammatory cytokines, and a lower hepatic and serum CRP. For RHF animals, there was only an attenuation in adiposity and visceral adipocyte hypertrophy, although it was sufficient to restore local leptin concentration similarly to LF. However, this regimen was not able to elevate the adiponectin concentration. In addition, the inflammatory cells infiltration was highly elevated. There was no reduction in proinflammatory cytokines concentration, despite IL-6, which was reduced slightly. Hepatic CRP concentration was attenuated, which did not reflect in its serum concentrations. In mice with diet-induced obesity, the weight loss by means a CR in a high fat diet was less effective in promoting wheight and adiposity losses and it did not improve visceral adipose tissue inflammation. It can be inferred that a lipid overload (60% from calories) as well as a saturated fatty acid surplus from the high fat diet were more determinant of local inflammation than caloric restriction per se.

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34

Belfer, Bonnee. "Factors associated with diet behaviour among individuals with type 2 diabetes mellitus attending an outpatient clinic." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80224.

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Diet recommendations to achieve target metabolic control for prevention of micro and macrovascular complications have been outlined. Although previous studies in individuals with type 2 diabetes have identified certain factors associated with adherence to diet recommendations, adherence is multi-factorial in nature and includes demographic, biological and psychosocial variables. Our main objective was to identify factors associated With dietary behaviour among individuals with type 2 diabetes attending an out-patient clinic. Furthermore, we attempted to identify factors associated with frequency of seeing the dietitian and stages of change far lower fat intake. Principal hypothesis: those who are younger, female, lower in body mass index (BMI), higher in education level, exposed to a dietitian in the past year, higher in stage of change, having greater nutrition knowledge, greater perception of risk and benefits as well as fewer perceived barriers, would consume less total and saturated fat. (Abstract shortened by UMI.)

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Camhi, Sarah Michelle. "The effects of low-fat diet and exercise on C-reactive protein and metabolic syndrome findings from a randomized controlled trial /." College Park, Md.: University of Maryland, 2008. http://hdl.handle.net/1903/8340.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2008.
Thesis research directed by: Dept. of Kinesiology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Tsihlias, Elizabeth Bessie. "Comparison of low- and high-fibre breakfast cereals and a high monounsaturated fat diet without breakfast cereals in the dietary management of type 2 diabetes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0007/MQ46135.pdf.

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VAGEDES, KASEY M. "CHANGES IN DIET QUALITY AND BLOOD PRESSURE AMONG ADOLESCENTS WITH HYPERTENSION IN RESPONSE TO A DIETARY INTERVENTION EMPHASIZING FRUITS, VEGETABLES AND LOW-FAT DAIRY PRODUCTS." University of Cincinnati / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1123090947.

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Panchal, Kunjal. "Determining the effects of low-dose ultraviolet radiation on the circadian rhythm of thermogenesis in brown adipose tissue of mice fed a high fat diet." Thesis, Panchal, Kunjal (2018) Determining the effects of low-dose ultraviolet radiation on the circadian rhythm of thermogenesis in brown adipose tissue of mice fed a high fat diet. Honours thesis, Murdoch University, 2018. https://researchrepository.murdoch.edu.au/id/eprint/43145/.

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Obesity and its resulting co-morbidities place a huge burden on the Australian healthcare system and economy. Alterations to the body’s normal circadian rhythm increase the risk of developing obesity and metabolic dysfunction. Like most metabolically active tissues, circadian rhythm has been observed in brown adipose tissue (BAT) a site of thermogenesis, whereby heat is released via the process of uncoupled respiration, involving uncoupling protein-1 (UCP-1). Activation of thermogenesis in BAT has potential to treat metabolic dysfunction. We have previously shown that ongoing exposure to low dose ultraviolet radiation (UVR) curbed weight gain and limited metabolic dysfunction in mice fed a high fat diet through mechanisms involving skin release of nitric oxide(1). We hypothesised that regular exposure to low dose UVR (1 kJ/m2 UVB radiation, twice a week) would alter the circadian rhythm of thermogenesis in BAT of mice fed a high fat diet, through skin release of nitric oxide. The circadian rhythm of thermogenesis in BAT was examined by monitoring expression of the UCP-1, using UCP-1 luciferase transgenic (‘thermomouse’, FVB/NJ background, n=12/treatment) male mice. In this mouse, UCP-1 expression in the interscapular BAT (iBAT) was tracked by monitoring bioluminescence following their injection with the substrate luciferin. The circadian rhythm analyses involved measuring UCP-1 bioluminescence in iBAT, as well as blood glucose and and interscapular skin temperature at 4-6 hourly intervals over a 28 hours time-course. This was done at baseline, and after 6 and 12 weeks of feeding mice a high or low fat diet.. There were four treatment groups in this 12-week study: 1. Mice fed a low-fat diet, and mock-irradiated (n=20); 2. Mice fed a high fat diet, and mock-irradiated (n=20); 3. Mice fed a high fat diet, and exposed twice a week to low dose UVR (1 kJ/m2)(n=20); or, 4. Mice fed a high fat diet and exposed twice a week to low dose UVR (1 kJ/m2) and topically treated with the nitric oxide scavenger, cPTIO (1 mM) (n=20). Signs of adiposity and metabolic dysfunction were also monitored by weighing mice, performing glucose and insulin tolerance tests, and measuring levels of liver steatosis via histopathology. Weak trends of circadian rhythmicity was noted in interscapular skin temperature during week 12. Ongoing UVR exposure to mice fed a high fat diet had moderately altered the level of UCP-1 expression in interscapular brown adipose tissue. Ongoing UVR exposure seemed to increase the potential of metabolic buffering in response to the high fat diet, and thus reducing the need for diet induced thermogenesis. More so, ongoing UVR suppressed the development of fatty liver disease in mice fed a high fat diet. The outcome of this study provides evidence that UVR exposure may suppress need for metabolic compensation in terms of diet-induced thermogenesis. The suppressive effects of UVR on signs of adiposity (e.g. hepatic steatosis and reduced WAT weights) were not linked with increased rates of thermogenesis in iBAT, in the absence of a circadian rhythm of UCP-1 expression in iBAT). And so if it is not the thermogenesis in BAT, it is important to examine the effects of UVR on other metabolic pathways and tissues as future focus.

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Dikotope, Sekgothe Abram. "Response of serum lipids to a fat meal in Black South African subjects with different apoe genotypes." Thesis, University of Limpopo (Turfloop Campus), 2013. http://hdl.handle.net/10386/1059.

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Thesis (M.Sc. (Chemical Pathology)) --University of Limpopo, 2013
Objectives The present study investigated how the serum lipids responded to a high-fat meal in black South African subjects with different APOE genotypes, a population that until recently was reported to be consuming a traditional diet of low fat and high carbohydrates. Methods Sixty students (males and females) of the University of Limpopo, Turfloop Campus were successfully genotyped using Restriction Fragment Length Polymorphism (RFLP) and grouped into four APOE genotype groups; ε2, ε2/ε4, ε3 and ε4. Only thirty-three subjects volunteered to participate in the oral fat-tolerance test (OFTT), but two were excluded for having abnormal total cholesterol (6.05 mmol/l) and LDL cholesterol (3.12 mmol/l) so only 31 subjects were left. The numbers per group were ε2=5, ε2/ε4=8, ε3=9 and ε4=9. After an overnight fast blood was drawn for measurements of baseline serum parameters. Subjects were administered a high fat meal 30 minutes after the baseline blood sample was drawn. Blood was drawn at intervals of 20, 40, 60, 120, 180, 240, 300 and 360 minutes for measurements of postprandial serum parameter levels. Serum parameters measured were triglyceride, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, glucose and insulin. Results Mean levels of serum lipids at baseline in mmol/l were as follows; group 1[TG=0.69(0.55-0.81), TCHOL=3.10±0.29, HDL-C=1.12±0.32, LDLC= 1.67±0.28]; group 2 [TG=0.61(0.53-1.00), TCHOL=2.98±0.53, HDLC= 1.20±0.37, LDL-C=1.43±0.37]; group 3 [TG=0.67(0.28-0.86), TCHOL=2.96±0.54, HDL-C=1.22±0.30, LDL-C=1.46±0.47]; group 4 [TG=0.76(0.51-1.16), TCHOL=3.27±0.51, HDL-C=1.12±0.17, LDLC= 1.79±0.47]. There was no significant difference in the mean levels of baseline triglyceride, total cholesterol, low density lipoprotein cholesterol, and ix high density lipoprotein cholesterol between the APOE groups hence no significant difference in the response to a fatty meal. Conclusions There was no significant change in serum lipid concentrations after a fatty meal in individuals with different APOE genotypes in a population that consume a traditional diet of low fat and high carbohydrates. Due to the small sample size, the results should be interpreted with caution. A larger study is recommended to ascertain the role of APOE genotypes on serum lipid response to a fatty meal in Black South African population.

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Johnson-Down, Louise. "A nutritional assessment of low income and multi-ethnic school children 9-12 years old and validation of alternative tools to measure fat intake." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23898.

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Despite the recognition that culturally diverse groups of children in low income areas are at elevated risk for future health problems, no dietary/nutritional studies have been reported on this population. Children aged 9-12 were sampled from schools selected on the basis of a poverty index and ethnicity. Nutritional information (24-hour recall, heights and weights) indicated children were growing well but a high proportion were overweight. A comparison of reported energy intake to calculated BMR indicated that overweight children under-estimated their intakes. Mean intakes met the Canadian RNIs except for calcium in 10-12 year old girls. Nutrient intake was related to family size, income and ethnic origin. Validation of two alternative tools to measure fat intake proved unsuccessful. In conclusion, dietary intake for these school children was adequate for all nutrients except calcium in 10-12 year old girls, but for approximately 40% of children, intake exceeded energy requirements.

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Thomas, Ingrid M. "Changes in Food Sources of Calcium, Potassium, and Magnesium in the Diets of Adolescents with Hypertension in Response to a Behavioral Nutrition Intervention Emphasizing Fruit, Vegetable, and Low-fat Dairy Foods." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1311775395.

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Bone, Julia Lizet. "The effects of environment, diet and exercise on the reliability and validity of measurements of resting metabolic rate and body composition in athletes." Phd thesis, Australian Catholic University, 2017. https://acuresearchbank.acu.edu.au/download/1b15286247babb3611beb870c0638a9665e6db2ec7481937bead51b19c647080/13327631/Bone_2017_The_effects_of_environment_diet_and.pdf.

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Resting energy expenditure (REE) can be reduced in situations of Low Energy Availability (LEA) in athletes, providing both a diagnostic sign of LEA and a potent risk factor for illness, injury and sub-optimal health. Current protocols regarding pre-measurement standardisation for REE are based on non-athlete populations, often following stringent rest and fasting protocols that would not be practical in a high performance environment. Furthermore, the reliability of measurements derived from these protocols has often been assessed in general and clinical populations and is unknown in an athlete population. Characteristics of the test protocol which alter an athlete's presentation (e.g. the location of the test, the duration of recovery from the last exercise bout) and changes in the athlete's own characteristics (changes in intramuscular solute and water content) were identified as variables that could affect the reliability of measurement of REE. This thesis presents a series of distinct but related studies which examine the how these variables affect the measurement and interpretation of REE in athletes. Study 1 examined the effect of testing location on REE in 32 elite and sub-elite athletes. REE was measured either at their bedside upon waking (inpatient) and as an outpatient (laboratory) protocol in a cross-over design following 8 h overnight fasts prior to each measurement. The day to day variation and reliability of each protocol was also assessed. There was no difference in REE when measured under the inpatient or outpatient protocols (7302 ± 1272 and 7216 ± 1119 kJ/d respectively). Both protocols showed good day to day reliability (inpatient 96%, outpatient 97%), however, the outpatient protocol was found to have a greater typical error (TE) (478 kJ/d) and to be less sensitive to changes in REE than the inpatient protocol (336kJ/d). Study 2 was a pilot study that investigated the effect of acute exercise on REE. A cross-over intervention was used in ten male athletes. Measurements were undertaken following training sessions in the morning and afternoon to determine REE approximately 12, 24, 36 and 48 h post exercise. There was a trend for REE to decrease with increasing rest time from exercise, with REE measured 48 h post exercise being significantly lower than REE measured at 12 h. However, the difference of 375 kJ/d was within the typical error determined in Study 1. Study 3 focused on the reliability of DXA estimates of lean mass (LM), which is important in the interpretation of REE relative to fat free mass (FFM). Intramuscular solutes and fluid were manipulated through a series of glycogen depletion, glycogen loading and creatine loading protocols in 18 male cyclists. Main outcome measures were total body and leg LM measured by dual x-ray absorptiometry (DXA), and total body water (TBW) measured by bioelectrical impedance spectroscopy (BIS). Changes in the mean were considered substantial if they reached the threshold for the smallest worthwhile effect of the treatment. There were substantial increases in TBW (2.3 and 2.5%), total body (2.1 and 3.0%) and leg LM (2.6 and 3.1%) following glycogen loading and the combined glycogen-creatine loading protocols respectively. Glycogen depletion caused a substantial decrease in leg LM (- 1.4%) and trivial decrease in total body LM (-1.3%). Creatine loading resulted in substantial increases in TBW and in trivial increases in LM measures. Study 4 addressed the potential development of a practical method to determine an athlete's glycogen stores in combination with DXA-derived estimates of LM by investigating the validity of measuring muscle glycogen via a non-invasive ultrasound technique. The same cohort and design involved in Study 2 was used in this investigation, with the ultrasound derived estimates of muscle glycogen concentration and changes in glycogen concentration being compared with results derived from direct (biopsy-derived) measurements. Poor correlations and substantially large or unclear errors were determined for the ultrasound estimates of muscle glycogen compared to muscle biopsy. Therefore, under the conditions employed in the current study design, the ultrasound technique was unable to accurately predict either single measures of muscle glycogen or changes in muscle glycogen stores. Study 5 applied the findings from Study 3 to investigate how changes in muscle glycogen influence the measurement and interpretation of REE in athletes, with particular interest in its effect on the sensitivity to detect changes in REE over time or as a result of an intervention. The investigation was undertaken within a larger study of the effect of adaptation to a low carbohydrate, high fat (LCHF) diet during a 21 day training camp for endurance athletes. Nineteen elite male race-walkers participated in this study; ten were assigned to the control group (CHO) where they received a diet providing 60% of energy from carbohydrate while nine were in the intervention group in which carbohydrate was restricted to70% of their energy intake for this period. Before and after the dietary interventions, measurements were made of REE, body composition (DXA) and TBW (BIS). Information derived from Study 3 to distinguish acute changes in TBW associated with changes in intramuscular glycogen and its bound water, from true (chronic) changes in muscle mass, was applied to the baseline and post-intervention measures of LM in all athletes. There was a significant decrease in FFM between Baseline and uncorrected Post-Intervention values FFM (-1.4; 95% CI -2.0, -0.80 kg). Using the uncorrected measures of FFM, we interpreted that no change in relative REE between baseline and post intervention occurred in either group. However, when the correction factor was applied to FFM of the LCHF group, correcting for the artefact of reduced muscle glycogen levels associated with restricted carbohydrate intake, we detected a decrease in relative REE post intervention measurements compared to baseline. The conclusions from this series of studies are; 1) Inpatient and outpatient protocols should not be used interchangeably when tracking changes in REE over time. 2) An 8 h overnight fast has good day to day reliability for both inpatient and outpatient protocols. 3) Rest time from exercise should be kept consistent between measures of REE for longitudinal monitoring. 4) Manipulations of muscle glycogen and creatine supplementation cause an artefact in the DXA which changes the estimate of LM accordingly. 5) Measurement of TBW via BIS is better suited to track changes in muscle glycogen than proprietary ultrasound technology. 6) A reduction in muscle glycogen stores, such as that achieved by the consumption of a LCHF diet, creates an artefact in the DXA-derived measurement of FFM, which could potentially alter the interpretation of relative REE. This knowledge should be integrated into best practice guidelines for the measurement of REE in athletes to enhance the reliability and validity of measurement as well as the interpretation of the results.

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Blomquist, Caroline. "Metabolic consequences of a Paleolithic diet in obese postmenopausal women." Doctoral thesis, Umeå universitet, Institutionen för folkhälsa och klinisk medicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-143133.

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Background Obesity, in particular abdominal adiposity, is associated with elevated fatty acids and pro-inflammatory adipokines, which are linked to ectopic fat storage and insulin resistance. During menopause, there is a redistribution of fat from the peripheral to abdominal depots. This transition is associated with an increased risk of type 2 diabetes and cardiovascular diseases. We hypothesized that a Paleolithic diet, with high proportions of lean meat, fish, vegetables, fruits, and oils, but devoid of dairy products and cereals, might have long-term beneficial effects on inflammation, fat metabolism, and circulating fatty acids. These effects might potentially reduce the risk of metabolic complications in postmenopausal women that are obese. Methods Postmenopausal women with obesity were studied before, after six months, and after 24 months of one of two specified ad libitum diets. One diet was a Paleolithic diet, in which approximately 30% of the total energy (E%) was protein, 30 E% was fat, and 40 E% was carbohydrate. The other diet was a prudent control diet, consistent with Nordic Nutrition recommendations of 15 E% protein, 25 E% fat, and 55 E% carbohydrate. Dietary intakes of polyunsaturated fatty acids and protein were validated objectively by measuring circulating and urinary biomarkers. Anthropometrics and diet reports were analyzed, and abdominal subcutaneous fat samples were evaluated for the expression of proteins key in inflammation and fat metabolism and for lipoprotein lipase mass and activity. In addition, blood samples were analyzed to determine concentrations of specific serum proteins, serum lipids, and the fatty acids carried in cholesterol esters. Results The Paleolithic diet group reported reduced intakes of saturated fatty acids and carbohydrates and elevated intakes of protein and unsaturated fatty acids, compared to baseline. The elevated intakes of polyunsaturated fatty acids and protein were objectively verified for this group. After 24 months, both diets were found to have beneficial effects on the expression of inflammation-related genes in adipose tissue and pro-inflammatory factors in the circulation. Compared to the control group, the Paleolithic diet group exhibited more pronounced reductions of circulating cardiometabolic risk factors, including the ratio of triglycerides to high density lipoprotein, lipogenic index, specific fatty acids, and indices of desaturase activities. After six months, the Paleolithic group also exhibited more pronounced reductions in lipogenesis-promoting factors, including the expression of key proteins in fat synthesis, the activity of lipoprotein lipase, and the activity of stearoyl-CoA desaturase 1, compared to the control group. Conclusion Long-term weight loss in postmenopausal obese women was accompanied by reductions in low-grade inflammation in adipose tissue and in the circulation. In addition, a Paleolithic diet, with a high content of unsaturated fatty acids and a low content of refined carbohydrates, appeared to provide greater reductions in cardiometabolic risk factors associated with insulin resistance and lipogenesis, compared to a prudent control diet.
Bakgrund De senaste decennierna har förekomsten av övervikt och fetma ökat kraftigt i stora delar av världen. Detta beror på en kombination av olika faktorer såsom specifika gener vilka främjar fettinlagring, men kanske främst ett överintag av energirik mat i kombination med minskad fysisk aktivitet. Fetma och specifikt bukfetma, vilket tilltar hos kvinnor efter klimakteriet (postmenopausala), ökar risken för höjda blodfettsnivåer och låggradig inflammation, vilket kan leda till utveckling av typ 2-diabetes samt hjärt- och kärlsjukdomar. Kost och viktnedgång är avgörande för bibehållen hälsa och av stort intresse är att urbefolkningar runt om i världen har låg förekomst av fetma, diabetes, hjärt- och kärlsjukdom, troligtvis kopplat till olika livsstilsfaktorer som högre fysisk aktivitet samt kostfaktorer. Syfte Vårt syfte var att undersöka metabola förändringar i fettväv och cirkulation hos postmenopausala kvinnor med fetma kopplat till en 24 månaders paleolitisk kostintervention. Den paleolitiska kosten, som ingick i studien består av en hög andel magert kött, fisk, grönsaker, frukt, nötter, oliv- och rapsolja och där mjölkprodukter och spannmål är uteslutna. Vår hypotes var att en paleolitisk kost med hög andel protein och omättade fettsyror har fördelaktiga långtidseffekter på inflammation, fettmetabolism och cirkulerande fettsyror jämfört med en kost baserad på Nordiska näringsrekommendationer med ett högt intag av kolhydrater. Metoder Postmenopausala kvinnor med fetma studerades före, vid sex månader och efter 24 månaders intag, utan energirestriktioner, av antingen en paleolitisk kost eller en kost enligt Nordiska näringsrekommendationer. Kroppsmätningar, kostregistreringar, genuttryck av nyckelproteiner i inflammation och fettmetabolism i fettväv samt koncentrationer av blodfetter, specifika proteiner och fettsyror bestämdes i plasma. Resultat I linje med rekommendationerna så rapporterade gruppen som åt den paleolitiska kosten ett minskat intag av mättat fett och kolhydrater samt ett ökat intag av protein och omättat fett jämfört med baslinjenivåerna. Det ökade intaget av fleromättade fettsyror och protein bekräftades med objektiva mätmetoder. Efter 24 månaders intervention uppvisade båda grupperna en jämförbar viktnedgång och en minskning av flertalet proinflammatoriska faktorer i såväl fettväv som i cirkulation. Den grupp som åt paleolitisk kost uppvisade en kraftigare reduktion av cirkulerande kardiometabola riskfaktorer som index för fettsyntes och desaturaser, specifika fettsyror samt kvoten triglycerider till HDL (high density lipoprotein). Efter sex månader bidrog den paleolitiska kosten också till en mer påtaglig minskning av faktorer involverade i fettinlagring, som uttryck av specifika nyckelproteiner i fettsyntes, aktivitet för lipoprotein lipas och stearoyl-CoA desaturase 1 index jämfört med kontrollkosten. Slutsatser En långvarig viktminskning hos postmenopausala kvinnor med fetma åtföljs av en minskad låggradig inflammation i fettväv och i cirkulation. En paleolitisk kost med hög andel omättade fettsyror och låga halt kolhydrater är kopplat till en kraftigare minskning av riskparametrar för insulinresistens och nyckelfaktorer för fettinlagring jämfört med en kontrollkost enligt Nordiska näringsrekommendationer.

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Lawrence, Judy Margaret. "To what extent do socio-economic status, knowledge, and confidence in cooking skills account for young women's choice of a diet low in fat and high in fruit and vegetables : what other factors may influence food choice in this group?" Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268774.

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Koutsari, Christina. "High-carbohydrate diets, exercise and postprandial lipaemia." Thesis, Loughborough University, 2000. https://dspace.lboro.ac.uk/2134/35001.

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Low-fat, high-carbohydrate diets are recommended by various scientific bodies for the prevention of coronary heart disease. However, these diets increase postprandial lipaemia and so their net benefit for coronary heart disease risk has been the subject of vigorous debate. Exaggerated postprandial lipaemia has been implicated in the development of atherosclerosis. Previous research suggests that physical exercise improves triacylglycerol metabolic capacity. The present thesis investigated whether exercise, when simultaneously adopted with a high-carbohydrate diet, could prevent the augmentation of postprandial lipaemia observed with this dietary change.

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Stonehouse, Gary George. "The effect of low protein diets on muscle and fat deposition in the pig." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520633.

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White, Jennifer. "Training in acquisition of texture-cured fasting-anticipatory satiety in rats using high- or low-fat diets." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0006/MQ44110.pdf.

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Park, Sunmin. "Effects of high unsaturated fat diets on low density lipoprotein receptor activity in freshly isolated human mononuclear cells /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487779120908357.

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Webster, Christopher. "Preliminary investigations for studying the effects of low carbohydrate high fat diets on gluconeogenesis in type 2 diabetes patients." Doctoral thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32363.

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Type 2 diabetes (T2D) is currently one of the major health challenges across the globe. Lifestyle changes are a key component of T2D management and there is growing interest in low carbohydrate high fat (LCHF) diets as a potential dietary strategy to improve glycaemic control, reduce T2D medication requirements, and improve body weight and lipid profiles. However, carbohydrate restriction is controversial. Results from observational studies generally do not support the food choices associated with carbohydrate restriction while results from short-term randomised controlled trials (RCTs) are more likely to show significant benefits of LCHF diets. Additionally, both study designs have limitations and opinion on LCHF diets is polarised due to ambiguities in how to interpret the available data. Chapter 1 of this thesis reviews the impact of prospective cohort studies, randomised controlled trials, and dietary policies on current opinions towards LCHF diets for the management of T2D. Uncertainty over the safety of LCHF diets remains a concern and additional observational studies and short-term RCTs of the same quality as existing research are unlikely to add any further clarity. For this reason, research focused on understanding the underlying mechanisms of carbohydrate restricted diets may be an alternative approach to alleviate or validate some of the concerns being expressed about LCHF diets. One such mechanism is the dysregulation of glucose production via gluconeogenesis, which is a key pathology of T2D but which has been incompletely studied. Indeed, the effects of LCHF eating on gluconeogenesis in T2D patients has not yet been studied, nor has gluconeogenesis been investigated in the context of T2D remission. This is an area of interest for future research and the aim of this thesis was to conduct preliminary studies to prepare the groundwork for such studies. There is large heterogeneity in the low carbohydrate diets that have been prescribed in controlled trials and the composition and characteristics of the LCHF diets that patients are finding effective in the real world is unknown. Study 1 (Chapter 2 of this thesis) aimed to better understand the LCHF diet by investigating the diet, diabetes status, and personal experiences of T2D patients who had self-selected and followed an LCHF diet of their own accord. This study was a multi-method investigation which consisted of quantitative assessments of diet and diabetes status, as well as in-depth interviews which were analysed using qualitative methods. Results from this study will be used to inform design and protocol decisions in future controlled trial studies. Study 2 (Chapter 3 of this thesis) piloted the use of stable isotope tracers for the quantification of endogenous glucose production and gluconeogenesis in the early postabsorptive state (5 hours after a meal). For methodological reasons, prior investigations have usually measured gluconeogenesis after an overnight fast and therefore, little is known about the effects of dietary composition on gluconeogenesis within the early post-absorptive state. Study 2 quantifies gluconeogenesis 5 hours after a meal and the validity of the data is discussed. Finally, Chapter 4 outlines future perspectives for research based on findings from Chapter 2 and Chapter 3.

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Mehling, Christine. "Comparison of low glycemic index high carbohydrate, high glycemic index high carbohydrate and monounsaturated fat-enriched diets on insulin sensitivity in the treatment of impaired glucose tolerance." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0017/MQ54157.pdf.

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Dissertations / Theses on the topic 'Low-fat diet'

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