Dissertations / Theses on the topic 'Longer-term impacts and outcomes'
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Fréchette, Sabrina. "Corporal Punishment: National Trends, Longer-Term Consequences, and Parental Perceptions of Physical Discipline." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35110.
Full textWinter, Joanne. "A mixed methods study exploring the longer term outcomes of 'successful' managed transfers between secondary schools focusing on the students' experience." Thesis, University of Essex, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605582.
Full textGeraci, Angela Ann. "The Impact of Psychosocial Outcomes in Long-Term Bariatric Patients." Diss., North Dakota State University, 2015. https://hdl.handle.net/10365/27937.
Full textHall, Alastair Eaton. "The new survivors : the longer term cognitive, scholastic and motor outcomes of a total Scottish population of surviving very low birthweight infants." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366189.
Full textSissons, P. "The longer-term labour market and community impacts of deindustrialisation : a comparison of the Northumberland coalfield and the Monongahela Valley mill towns." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/15811/.
Full textCheung, Him-chun Horace, and 張謙俊. "The impact of POSSUM score on long-term outcome of patients with colorectal cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45160752.
Full textBrännlund, Annica. "Non-market outcomes of education : the long-term impact of education on individuals' social participation and health in Sweden." Doctoral thesis, Umeå universitet, Sociologiska institutionen, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88369.
Full textChan, Raymond. "A long-term evaluation of the impact of rehabilitation in home (RIO) program on health outcomes in older adults." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/16623/1/Raymond_Chan_Thesis.pdf.
Full textChan, Raymond. "A long-term evaluation of the impact of rehabilitation in home (RIO) program on health outcomes in older adults." Queensland University of Technology, 2008. http://eprints.qut.edu.au/16623/.
Full textFunaki, Takeshi. "Impact of posterior cerebral artery involvement on long-term clinical and social outcome of pediatric moyamoya disease." Kyoto University, 2015. http://hdl.handle.net/2433/195941.
Full textYamane, Keiichiro. "Impact of Platelet Reactivity on Long-term Clinical Outcomes and Bleeding Events in Japanese Patients Receiving Antiplatelet Therapy with Aspirin." Kyoto University, 2013. http://hdl.handle.net/2433/174767.
Full textKim, Grace Eunhae. "The impact of obesity and age at diagnosis on the chronic quality of life and long-term outcomes of psoriasis patients." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17295917.
Full textHascoët, Sébastien. "Thérapies avancée de l'hypertension artérielle pulmonaire associée aux cardiopathies congénitales Pumpless Lung Assist as a Bridge to Medical Therapy in a Teenager With Pulmonary Arterial Hypertension and Partial Anomalous Pulmonary Venous Return Transplantation for Pulmonary Arterial Hypertension with Congenital Heart Disease: Impact of Current Therapeutic Approach Including a High-Priority Allocation Programme on Outcomes Outcome of adults with Eisenmenger syndrome treated with drugs specific to pulmonary arterial hypertension: A French multicentre study Long-term outcomesofpulmonaryarterial hypertension underspecific drugtherapyin Eisenmenger syndrome." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASQ010.
Full textAbstract: Congenital heart disease is the most common birth defect. Thanks to advances in surgical management, about 90% of children with congenital heart disease now live to adulthood. Nevertheless, the clinical course of these patients may be marked by complications, including pulmonary arterial hypertension. It may develop secondary to the absence or delay of treatment in childhood or to residual lesions. It is associated with an altered prognosis, primarily due to ventricular failure. Pulmonary arterial hypertension in these patients is characterized by variability in hemodynamic aspects depending on the underlying anatomical lesions. Its management remains variable, complex and controversial. Correction of underlying predisposing congenital heart disease is recommended or contraindicated depending on the degree of severity of pulmonary arterial hypertension. Specific pulmonary vasodilator drug therapies may be beneficial in more advanced disease. Patients with end stage disease may benefit from cardiopulmonary transplantation. The main objective of this thesis was to study the hemodynamic and prognostic impact of the different advanced therapeutic approaches currently available for the management of pulmonary arterial hypertension associated with congenital heart disease. Specific drug therapies, percutaneous shunt correction, circulatory support and cardiopulmonary transplant were studied. This thesis has shown that proactive management of pulmonary arterial hypertension in patients with congenital heart disease is associated with improved hemodynamic parameters, clinical parameters and improved prognosis. The results of this thesis call for further use and evaluation of advanced therapies to refine clinical management algorithms
Hamy, Anne-Sophie. "Identification of Factors Predicting Sensitivity or Resistance to Neoadjuvant Chemotherapy in Breast Cancer Neoadjuvant treatment : the future of patients with breast cancer Neoadjuvant treatment for intermediate/high-risk HER2-positive and triple-negative breast cancers: no longer an “option” but an ethical obligation Long-term outcome of the REMAGUS 02 trial, a multicenter randomised phase II trial in locally advanced breast cancer patients treated with neoadjuvant chemotherapy with or without celecoxib or trastuzumab according to HER2 status BIRC5 (survivin) : a pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy Beyond Axillary Lymph Node Metastasis, BMI and Menopausal Status Are Prognostic Determinants for Triple-Negative Breast Cancer Treated by Neoadjuvant Chemotherapy Pathological complete response and prognosis after neoadjuvant chemotherapy for HER2-positive breast cancers before and after trastuzumab era: results from a real-life cohort The presence of an in situ component on pre-treatment biopsy is not associated with response to neoadjuvant chemotherapy for breast cancer Chemosensitivity, tumor infiltrating lymphocytes (TILs), and survival of postpartum PABC patients treated by neoadjuvant chemotherapy Lymphovascular invasion after neoadjuvant chemotherapy is strongly associated with poor prognosis in breast carcinoma New insight for pharmacogenomics studies from the transcriptional analysis of two large-scale cancer cell line panels Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis A Stromal Immune Module Correlated with the Response to Neoadjuvant Chemotherapy, Prognosis and Lymphocyte Infiltration in HER2-Positive Breast Carcinoma Is Inversely Correlated with Hormonal Pathways Stromal lymphocyte infiltration after neoadjuvant chemotherapy is associated with aggressive residual disease and lower disease-free survival in HER2-positive breast cancer Interaction between molecular subtypes, stromal immune infiltration before and after treatment in breast cancer patients treated with neoadjuvant chemotherapy COX2/PTGS2 Expression Is Predictive of Response to Neoadjuvant Celecoxib in HER2-negative Breast Cancer Patients Celecoxib With Neoadjuvant Chemotherapy for Breast Cancer Might Worsen Outcomes Differentially by COX-2 Expression and ER Status: Exploratory Analysis of the REMAGUS02 Trial Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancer." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS129.
Full textNeoadjuvant chemotherapy (NAC i.e. chemotherapy before surgery) is increasingly being used for aggressive or locally advanced breast cancer (BCs). Beyond clinical benefits, it represents an opportunity to monitor in vivo sensitivity to treatment. Based on the analysis of datasets of BCs patients treated with NAC, we aimed at identifying mechanisms associated with resistance or sensitivity to treatment.In the first part, we evaluated biological, clinical, pathological and transcriptomic patterns. We demonstrated that unexplored pathological features such as post-NAC lymphovascular invasion may carried an important prognostic information.In a second part, we analyzed impact of imune infiltration in BC and we described extensively the changes of tumor infiltrating lymphocytes (TILs) between pre and post-NAC samples. We showed that the prognostic impact of TILs was different before and after NAC, and was opposite in TNBC and HER2-positive BCs. Finally, we investigated the impact of comedications use during NAC. We found both positive effects - while enhancing immune infiltration and response to treatment - and negative effects with deleterisous oncologic outcomes in specific patients subgroups. In conclusion, the neoadjuvant setting represents a platform to both generate and potentially validate research hypotheses aiming at increasing the efficacy of treatment. The public release of real-life datasets of BC patients treated with NAC would represent a major resource to accelerate BC research
(9183350), Laura Elizabeth Leavens. "After the Project is Over: Measuring Longer-Term Impacts of a Food Safety Intervention in Senegal." Thesis, 2020.
Find full textWe followed up with about 2,000 smallholder households in Senegal, two years after these households participated in a randomized controlled trial (RCT) aimed at reducing levels of aflatoxins in smallholders’ stored maize. In the initial intervention, treated households were provided with training on proper post-harvest practices, low-cost moisture meters for testing if maize was sufficiently dry to store, plastic tarps for drying maize of the ground, and hermetic (airtight) storage bags to mitigate aflatoxin development in stored maize. Using cross-sectional follow up data on aflatoxins levels and drying and storage practices from 2019 along with baseline demographic data from 2016, we estimate both the longer-term intention-to-treat (ITT) effects and the treatment on the treated (TOT) effects that the four inputs provided on households’ aflatoxins levels in stored maize. The ITT analyses estimate the intervention’s average effect by treatment group, but this may underestimate the true impact for households who complied with recommended post-harvest practices and adopted the recommended technologies. The TOT analyses estimate the local average treatment effects (LATE) of the intervention, that is its impacts on those who were driven by the intervention to follow best practices or use a given technology. Since the decision to follow these practices or adopt a technology was not random, we instrumented the usage decision with the exogenous, random treatment group assignment to get an unbiased estimate. Outside of our main models, we conducted a heterogeneity analysis to test if households with different characteristics benefit differently from the intervention. We interacted each treatment assignment with various household characteristics, including the woman’s level of involvement in the intervention. Additionally, we estimate the cost-effectiveness of providing training and a tarp, according to WHO guidelines for public health interventions.
Guo, Fei. "The impact of term-time working on college outcomes in China." Thesis, 2014. https://doi.org/10.7916/D8ZC811D.
Full textNenshi, Rahima N. "The Ontario Structures of Care in Colorectal Cancer Surger Study (OSCRC): Assessing Hospital Level Variation and Impact on Short Term Patient Outcomes." Thesis, 2009. http://hdl.handle.net/1807/18932.
Full textSun, Yanni. "The long term outcome and impact of multidrug-resistant tuberculosis in Henan Province, China." Phd thesis, 2013. http://hdl.handle.net/1885/150662.
Full textFerreira, Francisca Isabel Barros. "The Impact of Very Short-term Variability of Blood Pressure in Outcome after Successful Thrombectomy." Master's thesis, 2020. https://hdl.handle.net/10216/128810.
Full textBackground and Purpose: We aim to determine if the very short-term blood pressure variability (BPV) after successful endovascular treatment of acute ischemic stroke has a relevant impact in the clinical outcome. Methods: This is a prospective multicenter study with inclusion of consecutive AIS patients with occlusion of intracranial anterior circulation vessels who achieved successful recanalization (modified Treatment In Cerebral Ischemia grades 2b-3) after thrombectomy. Very short-term BPV was assessed by spectral analysis of spontaneous fluctuations of beat-to-beat systolic blood pressure values recorded by finger plethysmography with Finometer device. Outcomes included independence at 90 days (modified Rankin scale 0-2) and the initial clinical response to mechanical thrombectomy. Results: We included 121 patients. Increased BPV at high frequencies (rapid oscillations) was independently associated with poor functional outcome at 90 days (normalized units, odds ratio (OR) = 0.56, 95% confidence interval (CI) 0.35 - 0.88, p=0.01; low/high frequency ratio OR = 1.38, CI 1.09 - 1.76, p<0.01) and early neurological recovery (normalized units, OR = 0.67, CI 0.46 - 0.98, p=0.04) in multivariate analysis. Conclusions: The magnitude of rapid oscillations of blood pressure has a significant impact in early neurological recovery and late functional outcome of ischemic stroke patients after successful recanalization. Very short-term BPV can be assessed quickly throughout the post intervention period and potentially contribute to a more efficient blood pressure control in AIS patients submitted to endovascular treatment.
Ferreira, Francisca Isabel Barros. "The Impact of Very Short-term Variability of Blood Pressure in Outcome after Successful Thrombectomy." Dissertação, 2019. https://hdl.handle.net/10216/128810.
Full textBackground and Purpose: We aim to determine if the very short-term blood pressure variability (BPV) after successful endovascular treatment of acute ischemic stroke has a relevant impact in the clinical outcome. Methods: This is a prospective multicenter study with inclusion of consecutive AIS patients with occlusion of intracranial anterior circulation vessels who achieved successful recanalization (modified Treatment In Cerebral Ischemia grades 2b-3) after thrombectomy. Very short-term BPV was assessed by spectral analysis of spontaneous fluctuations of beat-to-beat systolic blood pressure values recorded by finger plethysmography with Finometer device. Outcomes included independence at 90 days (modified Rankin scale 0-2) and the initial clinical response to mechanical thrombectomy. Results: We included 121 patients. Increased BPV at high frequencies (rapid oscillations) was independently associated with poor functional outcome at 90 days (normalized units, odds ratio (OR) = 0.56, 95% confidence interval (CI) 0.35 - 0.88, p=0.01; low/high frequency ratio OR = 1.38, CI 1.09 - 1.76, p<0.01) and early neurological recovery (normalized units, OR = 0.67, CI 0.46 - 0.98, p=0.04) in multivariate analysis. Conclusions: The magnitude of rapid oscillations of blood pressure has a significant impact in early neurological recovery and late functional outcome of ischemic stroke patients after successful recanalization. Very short-term BPV can be assessed quickly throughout the post intervention period and potentially contribute to a more efficient blood pressure control in AIS patients submitted to endovascular treatment.
Tseng, Li-Jung, and 曾麗蓉. "Impact of Age-Adjusted Charlson Comorbidity Index on Hospital Survival and Short-Term Outcome of Patients with Extracorporeal Cardiopulmonary Resuscitation." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/27779r.
Full text國立陽明大學
急重症醫學研究所
107
Extracorporeal cardiopulmonary resuscitation (ECPR) has gradually come to be regarded as an effective therapy, but the hospital mortality rate after ECPR is still high and unpredictable. The present study tested whether age-adjusted Charlson comorbidity index (ACCI) can be used as an objective selection criterion to ensure the most efficient utilization of medical resources. Adult patients (age 18 years) receiving ECPR at our institution between 2006 and 2015 were included. Data regarding ECPR events and ACCI characteristics were collected immediately after the extracorporeal membrane oxygenation (ECMO) setup. Adverse events during hospitalization were also prospectively collected. The primary endpoint was survival to hospital discharge. The second endpoint was the short-term (2-year) follow-up outcome. A total of 461 patients included in the study were grouped into low ACCI (ACCI 0-3) (240,52.1%) and high ACCI (ACCI 4-13) (221,47.9%) groups. The -median ACCI was 2 (interquartile range,IQR:1-3) and 5 (IQR:4-7) for the low and high ACCI groups, respectively. Cardiopulmonary resuscitation (CPR)-to-ECMO duration was comparable between the groups(ACCI 0-3=42.1±25.6,ACCI 4-13=41.3±20.7 min;p = 0.754). Regarding the hospital survival rate, 256 patients (55.5%) died on ECMO support. A total of 205 patients (44.5%) were successfully weaned off ECMO, but only 138 patients (29.9%) survived to hospital discharge (32.1% and 27.6% in low and high ACCI group,p = 0.291). Multivariate logistic regression analysis revealed CPR duration before ECMO run (CPR-to-ECMO duration) and a CPR cause of septic shock to be significant risk factors for hospital survival after ECPR (p = 0.043 and 0.014, respectively), whereas age and ACCI were not ( p = 0.334 and 0.164, respectively). The 2-year survival rate after hospital discharge for the 138 hospital survivors was 96% and 74% in the low and high ACCI groups, respectively ( p = 0.002). High ACCI before ECPR does not predict a poor outcome of hospital survival. Therefore, ECPR should not be rejected solely due to high ACCI. However, high ACCI in hospital survivors is associated with a higher 2-year mortality rate than low ACCI, and patients with high ACCI should be closely followed up.
Brown, Ryan. "The Impact of a Mother's Wellbeing During Pregnancy on the Human Capital Endowment and Long Term Economic Outcomes of the In Utero Child." Diss., 2014. http://hdl.handle.net/10161/8702.
Full textThe focus of this dissertation is to help explore, disentangle, and mechanize the role of the social and physical environment during gestation on the in utero child's later life outcomes. Specifically this work uses theoretical underpinnings adopted from the medical and epidemiological literature to inform the use of various applied econometric techniques on population representative data to rigorously examine the impact of a mother's mental and physical wellbeing during pregnancy on the human capital endowment and long-term economic outcomes of the in utero child. After a brief introduction, the second chapter reexamines the pioneering work by Douglas Almond (2006), which is thought to establish that in utero exposure to an adverse disease environment has a large, negative impact on health and socioeconomic prosperity that reaches well into adulthood. The analysis in this section casts doubt on the identification strategy used in that seminal work, and suggests that conclusions about the deleterious impact of in utero exposure to the influenza pandemic on socioeconomic prosperity in adulthood are, at best, premature. The third and fourth chapters delve into the topic of the impact of a mother's mental health during pregnancy on the birth outcomes of the in utero child. Utilizing two traumatic and unanticipated events, the terrorist attacks of September 11th, 2001 and the surge in Mexican Drug War violence, these chapters provide strong evidence that exposure to increased maternal anxiety has a significant negative impact on the early-life health of the in utero child.
Dissertation