Academic literature on the topic 'Lofredes'

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Journal articles on the topic "Lofredes"

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Koga, Takayuki, Hiroshi Kida, Yutaro Yamasaki, Loreto B. Feril, Hitomi Endo, Keiji Itaka, Hiroshi Abe, and Katsuro Tachibana. "Intracranial Gene Delivery Mediated by Albumin-Based Nanobubbles and Low-Frequency Ultrasound." Nanomaterials 14, no. 3 (January 30, 2024): 285. http://dx.doi.org/10.3390/nano14030285.

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Research in the field of high-intensity focused ultrasound (HIFU) for intracranial gene therapy has greatly progressed over the years. However, limitations of conventional HIFU still remain. That is, genes are required to cross the blood-brain barrier (BBB) in order to reach the neurological disordered lesion. In this study, we introduce a novel direct intracranial gene delivery method, bypassing the BBB using human serum albumin-based nanobubbles (NBs) injected through a less invasive intrathecal route via lumbar puncture, followed by intracranial irradiation with low-frequency ultrasound (LoFreqUS). Focusing on both plasmid DNA (pDNA) and messenger RNA (mRNA), our approach utilizes LoFreqUS for deeper tissue acoustic penetration and enhancing gene transfer efficiency. This drug delivery method could be dubbed as the “Spinal Back-Door Approach”, an alternative to the “front door” BBB opening method. Experiments showed that NBs effectively responded to LoFreqUS, significantly improving gene transfer in vitro using U-87 MG cell lines. In vivo experiments in mice demonstrated significantly increased gene expression with pDNA; however, we were unable to obtain conclusive results using mRNA. This novel technique, combining albumin-based NBs and LoFreqUS offers a promising, efficient, targeted, and non-invasive solution for central nervous system gene therapy, potentially transforming the treatment landscape for neurological disorders.
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2

Gimbernat González, Esther. "Sobre Gino Lofredo, Tráfico de identidades." Revista Iberoamericana 60, no. 166 (June 5, 1994): 588–90. http://dx.doi.org/10.5195/reviberoamer.1994.6534.

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3

GORMLEY, LANE. "PARACONSISTENT LOGIC (in Italian), by Nicola Grana. Lofredo Editore, Naples, 1983. 134 pp." International Journal of General Systems 13, no. 4 (November 1987): 361–63. http://dx.doi.org/10.1080/03081078708934985.

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Sobczak, Jober Fernando, Jullyana Cristina Magalhães Silva M. Sobczak, Yuri Fanchini Messas, Hebert da Silva Souza, and João Vasconcellos-Neto. "A New Record of a Host-Parasitoid Interaction: Hymenoepimecis veranii Lofredo & Penteado-Dias, 2009 (Hymenoptera: Ichneumonidae) Parasitizing Araneus orgaos Levi, 1991 (Araneae: Araneidae)." Journal of Insect Behavior 27, no. 6 (September 19, 2014): 753–58. http://dx.doi.org/10.1007/s10905-014-9467-z.

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Procopé, J. F. "(G.) Casertano (ed.) Democrito dall' atomo alla città. Naples: Lofredo. 1983. Pp. 193. - (G.) Ibscher Demócrito y sus sentencias sobre ética y educación. Una introducción al pensamiento del atomista de Abdera. Lima-Perú: Universidad Nacional Mayor de San Marcos. I. 1983. Pp. 444, II. 1984, Pp. 568." Journal of Hellenic Studies 109 (November 1989): 238–39. http://dx.doi.org/10.2307/632092.

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de Beer, CS (Fame). "'n Lofrede vir taal." Tydskrif vir Geesteswetenskappe 60, no. 3 (2020). http://dx.doi.org/10.17159/2224-7912/2020/v60n3a16.

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de Beer, CS (Fame). "'n Lofrede vir taal." Tydskrif vir Geesteswetenskappe 60, no. 3 (2020). http://dx.doi.org/10.17159/2224-7912/2020/v60n3a16.

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Dissertations / Theses on the topic "Lofredes"

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Lofredi, Roxanne [Verfasser]. "Characterization of inhibitory and projection specific neurons of the presubiculum / Roxanne Lofredi." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1126505005/34.

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Books on the topic "Lofredes"

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Antologija srpskih pohvala: XIII-XX vek. Beograd: Draslar partner, 2006.

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2

Moor, Piet de. Brieven aan mijn postbode, Will Tura en Peter Vandermeersch: Een lofrede op vrijheid, schoonheid en verbeeldingskracht. Amersfoort: Aspekt, 2006.

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Moor, Piet de. Brieven aan mijn postbode, Will Tura en Peter Vandermeersch: Een lofrede op vrijheid, schoonheid en verbeeldingskracht. Amersfoort: Aspekt, 2006.

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