Relevant bibliographies by topics / Locus Coeruleus

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Locus Coeruleus'

Author: Grafiati
Published: 4 June 2021
Last updated: 24 February 2024

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Journal articles on the topic "Locus Coeruleus"

1

KOÇ, Gizem Gül. "Ergonomi ve Locus Coeruleus." Arşiv Kaynak Tarama Dergisi 31, no. 4 (December 30, 2022): 284–92. http://dx.doi.org/10.17827/aktd.1220966.

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Pons ta tüp şeklinde bir anatomik şekle sahip olan locus coeruleus küçük yapısına rağmen nerdeyse tüm merkezi sinir sistemini (M.S.S’yi) etkilemektedir. Yaklaşık iki yüzyıl önce fark edilen locus coeruleus, noradrenalin kaynağı olup hücrelerinin içerdiği nöromelanin pigmentinden kaynaklı koyu mavi olarak görülmektedir. Bu nedenle, Latince’de coeruleus (gökyüzü mavisi) olarak isimlendirilmiştir. Ponsta bilateral olarak yerleşim gösteren bu hücre grubu yaklaşık olarak 45,000 ile 50,000 hücre içermektedir. Son yıllarda gelişen teknoloji ve optogenetik çalışmalar, fonksiyonel manyetik rezonans görüntüleme (MRG) teknikleri ile locus coeruleus ile ilgili pek çok bilginin elde edilmesini sağlamıştır. Bu anatomik yapının dikkat, uyanıklık, stress gibi bilişsel özelliklerde anahtar rol oynadığı bilinmektedir. Okülomotor fonksiyonların zihinsel işlevleri yansıtması nedeniyle özellikle ergonomi alanında çalışan mühendislerin ilgi odağı olmuştur. Sunulan bu derleme çalışmasında locus coeruleusun anatomik yapısı, fizyolojik özellikleri ve nöroergonomi alanında klinik öneminin ortaya konması amaçlanmıştır. Ayrıca, nörobilim ve beyin görüntüleme konusunda meydana gelen gelişmeler ışığında bu anatomik yapının nöroergonomide de ele alınması gerektiğini ve bu alanda yapılacak çalışmaların artması görüşündeyiz.
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2

Benarroch, Eduardo E. "Locus coeruleus." Cell and Tissue Research 373, no. 1 (July 7, 2017): 221–32. http://dx.doi.org/10.1007/s00441-017-2649-1.

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3

Bouret, Sebastien, and Susan Sara. "Locus coeruleus." Scholarpedia 5, no. 3 (2010): 2845. http://dx.doi.org/10.4249/scholarpedia.2845.

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Betts, Matthew J., Evgeniya Kirilina, Maria C. G. Otaduy, Dimo Ivanov, Julio Acosta-Cabronero, Martina F. Callaghan, Christian Lambert, et al. "Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases." Brain 142, no. 9 (July 20, 2019): 2558–71. http://dx.doi.org/10.1093/brain/awz193.

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Abstract Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathological manifestations in Alzheimer’s disease, atypical neurodegenerative dementias and Parkinson’s disease. Moreover, as the functional sensitivity of the noradrenergic system is likely to change with disease progression, in vivo measures of locus coeruleus integrity could provide new pathophysiological insights into cognitive and behavioural symptoms. Locus coeruleus imaging also holds the promise to stratify patients into clinical trials according to noradrenergic dysfunction. In this article, we present a consensus on how non-invasive in vivo assessment of locus coeruleus integrity can be used for clinical research in neurodegenerative diseases. We outline the next steps for in vivo, post-mortem and clinical studies that can lay the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenerative diseases.
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Morris, Laurel S., Jordan G. McCall, Dennis S. Charney, and James W. Murrough. "The role of the locus coeruleus in the generation of pathological anxiety." Brain and Neuroscience Advances 4 (January 2020): 239821282093032. http://dx.doi.org/10.1177/2398212820930321.

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This review aims to synthesise a large pre-clinical and clinical literature related to a hypothesised role of the locus coeruleus norepinephrine system in responses to acute and chronic threat, as well as the emergence of pathological anxiety. The locus coeruleus has widespread norepinephrine projections throughout the central nervous system, which act to globally modulate arousal states and adaptive behavior, crucially positioned to play a significant role in modulating both ascending visceral and descending cortical neurocognitive information. In response to threat or a stressor, the locus coeruleus–norepinephrine system globally modulates arousal, alerting and orienting functions and can have a powerful effect on the regulation of multiple memory systems. Chronic stress leads to amplification of locus coeruleus reactivity to subsequent stressors, which is coupled with the emergence of pathological anxiety-like behaviors in rodents. While direct in vivo evidence for locus coeruleus dysfunction in humans with pathological anxiety remains limited, recent advances in high-resolution 7-T magnetic resonance imaging and computational modeling approaches are starting to provide new insights into locus coeruleus characteristics.
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Hansen, Niels. "The Longevity of Hippocampus-Dependent Memory Is Orchestrated by the Locus Coeruleus-Noradrenergic System." Neural Plasticity 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/2727602.

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The locus coeruleus is connected to the dorsal hippocampus via strong fiber projections. It becomes activated after arousal and novelty, whereupon noradrenaline is released in the hippocampus. Noradrenaline from the locus coeruleus is involved in modulating the encoding, consolidation, retrieval, and reversal of hippocampus-based memory. Memory storage can be modified by the activation of the locus coeruleus and subsequent facilitation of hippocampal long-term plasticity in the forms of long-term depression and long-term potentiation. Recent evidence indicates that noradrenaline and dopamine are coreleased in the hippocampus from locus coeruleus terminals, thus fostering neuromodulation of long-term synaptic plasticity and memory. Noradrenaline is an inductor of epigenetic modifications regulating transcriptional control of synaptic long-term plasticity to gate the endurance of memory storage. In conclusion, locus coeruleus activation primes the persistence of hippocampus-based long-term memory.
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Maeda, Toshihiro. "The locus coeruleus: history." Journal of Chemical Neuroanatomy 18, no. 1-2 (February 2000): 57–64. http://dx.doi.org/10.1016/s0891-0618(99)00051-4.

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Halliday, Glenda, and Kerry Baker. "NORADRENERGIC LOCUS COERULEUS NEURONS." Alcoholism: Clinical and Experimental Research 20, no. 1 (February 1996): 191–92. http://dx.doi.org/10.1111/j.1530-0277.1996.tb01064.x.

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Pohl, Robert, John M. Rainey, Aurelio Ortiz, Vikram K. Yeragani, and Kenneth I. Kaitin. "Locus coeruleus and anxiety." Biological Psychiatry 22, no. 1 (January 1987): 116–17. http://dx.doi.org/10.1016/0006-3223(87)90141-7.

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Bulhões, Margarida, Maria Margarida Ribeiro, and Luísa Veiga. "Ressonância Magnética no estudo do Locus Coeruleus e a relação com o processo cognitivo de atenção: revisão sistemática." ROENTGEN-Revista Científica das Técnicas Radiológicas 3, no. 2 (July 20, 2022): 40–51. http://dx.doi.org/10.46885/roentgen.v3i2.86.

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Introdução: A degeneração progressiva dos neurónios do Locus Coeruleus associada à diminuição de recetores adrenérgicos, alvos da Noradrenalina, conduz a uma diminuição da função cerebral, provocando uma baixa resposta hemodinâmica e atividade neuronal. A disfunção noradrenérgica pode, ainda, interromper a capacidade de monitorizar estímulos externos e alterar o processo cognitivo da atenção, como acontece na Doença de Alzheimer e na Doença de Parkinson. Objetivos: A investigação procurou unir estudos estruturais e funcionais do Locus Coeruleus, incluindo estudos pupilométricos na avaliação da atenção seletiva visual, que atendessem à resposta cerebral bem como à progressão da doença, com a finalidade de correlacionar o processo cognitivo de atenção com a imagem obtida por Ressonância Magnética do Locus Coeruleus. Materiais e Métodos: A estratégia de pesquisa foi desenvolvida para encontrar todos os potenciais artigos relevantes num conjunto de fontes, como: as bases de dados bibliográficas de biomedicina; bases de registos de ensaios clínicos randomizados e quase randomizados; repositórios científicos e sites agregadores de bases bibliográficas. Resultados: Estudos que avaliaram o Locus Coeruleus por Ressonância Magnética demonstram variações morfológicas dependentes da idade e estudos funcionais, juntamente com testes pupilométricos, apresentaram alterações na neuromodulação percutindo-se na seletividade da atenção. Conclusão: A compilação da análise dos estudos forneceu dados para o estudo do Locus Coeruleus e a relação com o processo cognitivo de atenção. Cientificamente, todos os aspetos morfológicos e funcionais sugerem possibilitar a análise da disfunção noradrenérgica sob o campo da imagem de Ressonância Magnética para compreender a incapacidade do Locus Coeruleus em monitorizar estímulos externos e alterar o processo cognitivo da atenção.
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Dissertations / Theses on the topic "Locus Coeruleus"

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Signoret-Genest, Jérémy. "Implication physiopathologique du locus coeruleus dans la migraine." Thesis, Université Clermont Auvergne‎ (2017-2020), 2017. http://www.theses.fr/2017CLFAS018.

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Résumé indisponible
Twelve percent of the world population suffers from migraine and its cost is estimated at $18 billion per year in Europe. The frequency of attacks may increase over time in some migraineurs, evolving from episodic migraine (0 to 14 days of migraine/month) to chronic migraine (more than 15 days of migraine/month). Propranolol is one of the major prophylactic treatments of migraine, used to decrease the frequency of the attacks. However, its mechanism of action is largely unknown. Thus, using an animal model of repeated chemical stimulation of the dura, along with behavioural, electrophysiological, and immunohistochemical approaches, we assessed the prophylactic effect of per os propranolol on central sensitisation. It was able to prevent (i) the aggravation and persistence of central sensitisation as well as (ii) the alteration of descending controls of pain (iii) dural stimulation-induced activation of the locus coeruleus (LC). Recording simultaneously from Sp5C and LC then allowed us to demonstrate that (iv) LC integrates both cutaneous and meningeal nociceptive information and (v) LC exerts a facilitatory effect on Sp5C excitability, while in pathological conditions, (vi) integration of trigeminal nociception by LC was decreased while (vii) the modulation of Sp5C by LC was altered. We then tested the effect on central sensitisation of propranolol microinjection in the LC. It (viii) prevented central sensitisation but (ix) couldn’t reverse it. Finally, we investigated the mechanism of action of propranolol in the LC; the results suggested that (x) propranolol alters intrinsic properties of LC, thereby dampening its ability to facilitate Sp5C. In conclusion, our results revealed the facilitatory influence of the LC on trigeminal nociception, suggesting that the LC could play a facilitating role in triggering migraine headaches
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Finlayson, Paul George. "Electrophysiological studies of locus coeruleus neurons in culture." Thesis, University of Ottawa (Canada), 1986. http://hdl.handle.net/10393/21038.

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Delagrange, Philippe. "Locus coeruleus et comportements d'attention chez le chat." Paris 6, 1990. http://www.theses.fr/1990PA066471.

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Des donnees anterieures, chez le chat, ayant indique l'importance de la mediation noradrenergique dans la modulation de l'attente, nous avons recherche la structure noradrenergique controlant ce comportement ainsi que le rythme electrocortical mu, localise dans l'aire si, qui lui est associe. Le marquage par transport retrograde de hrp a mis en evidence la projection du locus coeruleus (lc) sur le foyer thalamique commandant les rythmes mu. Une etude immunocytochimique nous a permis d'etudier des terminaisons noradrenergiques pericellulaires au niveau de ce foyer. Afin de determiner le type de modulation exercee par le lc sur le comportement et l'ecog d'attente, nous avons pratique des desafferentations noradrenergiques par un neurotoxique (dsp4) detruisant specifiquement les terminaisons noradrenergiques issues du lc ainsi que des lesions du lc. Nous concluons que les neurones noradrenergiques du lc exercent une influence inhibitrice sur le comportement d'attente et une exacerbation du comportement d'attention focalisee et des rythmes beta l'accompagnant. Enfin nous avons voulu connaitre le devenir des messages somesthesiques sous l'effet soit du developpement du rythme mu, soit lorsque le systeme noradrenergique est mis en jeu, c'est-a-dire lors d'un accroissement du niveau de vigilance. Nous montrons que pour un stimulus somesthesique donne, le message transthalamique est desorganise seulement pendant les episodes de mu. D'autre part, il nous est apparu que le rapport signal/bruit est plus faible en vigilance intense et augmente lorsque le niveau baisse. Le message serait attenue lorsque l'animal entre dans un etat d'immobilite vigilante
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Dubé, Gilles R. "Modulation of neurotransmission in locus coeruleus by metabotropic glutamate receptors." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ28337.pdf.

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McFadzean, I. "Kappa opioid actions in the rat locus coeruleus in vitro." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233318.

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Intracellular recordings were made from neurones of the rat locus coeruleus (lc) contained within a brain slice maintained in vitro. When applied to the slice in known concentrations, K opioid receptor agonists produced a concentration-dependent, naloxone-reversible depression of the electrically evoked excitatory post-synaptic potential (epsp). This effect of K agonists was observed in the absence of changes in the membrane potential or input resistance of the post-synaptic cell. Similarly, the K agonists had no effect on the tetrodotoxin-resistant action potential waveform. Naloxone antagonised the response to U50488 with an apparent dissociation equilibrium constant (Kd) of 28 nM, consistent with the response being mediated via K opioid receptors. In contrast, u opioid receptor agonists caused a membrane hyperpolarisation concomitant with a fall in neuronal input resistance, and depressed the tetrodotoxin-resistant action potential. These effects were concentration-dependent and antagonised by naloxone; the hyperpolarising action of [D-Ala2 , NMePhe4 , Gly-ol5 ] enkephalin (DAGO) was antagonised by naloxone with a Kd of 1.5 nM. These findings are in agreement with previous reports that u receptor activation increases a potassium conductance in lc neurones. The epsp was depressed, but not abolished, by the excitatory amino acid antagonists, 2-amino-5-phosphonovaleric acid (2APV) and kynurenic acid, suggesting that the epsp was at least partly mediated by an excitatory amino acid. U50488 did not depress the depolarisation produced by local application of L-glutamic acid. In addition to the epsp, a noradrenergic inhibitory post-synaptic potential (ipsp) could be evoked in lc neurones. U50488 depressed the ipsp, but this effect was not reversed by naloxone and therefore not mediated via opioid receptors. U50488 had no effect on the all or nothing depolarising potential which could be evoked in a proportion of lc neurones. The effect of U50488 on the epsp was reduced when experiments were performed in the presence of agents - either barium, quinine or 4-aminopyridine - which block potassium conductances. An in vitro autoradiographic study of 3 H bremazocine binding within the lc revealed that the majority of binding was displaced by a combination of unlabelled DAGO and [D-Ser2 ] Leu enkephalin Threonine (DLSET) and so represented u sites. A significant proportion however, was displaceable by unlabelled U50488 and thus represented K binding sites. It is concluded that K opioid receptors are situated pre-synaptically within the lc and when activated depress excitatory synaptic transmission.
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Perna, Marla K., Katalin Szebeni, Craig A. Stockmeier, and Gregory A. Ordway. "Glia in the Locus Coeruleus in Major Depression and Suicide." Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/8623.

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Recent postmortem studies have demonstrated deficits in glia in major depressive disorder, including reductions in the astrocyte specific interfilament glial fibrillary acidic protein (GFAP) in the prefrontal cortex and cerebellum of depressed patients. Astrocytes serve important roles in influencing neuronal activity in the CNS, one of which is to remove neurotransmitters from the extracellular space. The present study investigated the levels of GFAP in the locus coeruleus (LC) of human subjects. The LC is the principal source of norepinephrine in the brain and neurochemical pathology of the LC has been demonstrated in major depressive disorder (MDD) and suicide. Tissue punches of the LC were obtained from postmortem brains collected from subjects with MDD who died by suicide and psychiatrically normal control subjects (n=9 per group). The age of the subjects ranged from 17 to 65 years (control 37±4 y; MDD 39±5 y) and postmortem intervals ranged from 17 to 44 h (control 20±1 h; MDD 25±3 h). GFAP-immunoreactivity (ir) was measured by quantitative Western blotting. Alpha-tubulin-ir was used to control for protein loading and transfer. Amounts of GFAP-ir were highly variable within both control and MDD subjects, ranging 15-fold across control subjects and 24-fold across MDD subjects. There was a modest trend for lower GFAP-ir in the LC from MDD subjects relative to control subjects, but this difference was not significantly different. In control subjects, there was no significant correlation of GFAP-ir levels with age. In contrast, GFAP-ir levels were positively correlated with age in MDD subjects. In younger MDD subjects (<40 y), GFAP-ir was consistently lower as compared to matched control subjects. Amounts of GFAP-ir did not correlate with postmortem intervals. These findings are consistent with a previous report demonstrating age effects on GFAP in frontal cortex in depressed but not control subjects. Glia deficits reported in frontal cortex and cerebellum from depressed subjects may also occur in the brainstem, and these deficits may contribute to disruption of monoamine chemistry in depression. Given the variability of GFAP levels in the LC between subjects, other markers of glia should be pursued to evaluate the potential role of glia in brainstem pathology associated with MDD.
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ISAIAS, IOANNIS UGO. "A ROLE FOR LOCUS COERULEUS IN PARKINSON TREMOR - EXPERIMENTAL STUDIES." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/215235.

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Although Parkinson disease (PD) is characterized by the degeneration of nigrostriatal dopamine (DA) neurons, historic and more recent anatomopathological studies documented also an involvement of the serotonergic and cholinergic systems as well as a profound loss of neurons from the locus coeruleus (LC), the major noradrenergic (NAergic) nucleus in the brain. In the following studies, I will provide preliminary evidence of a new provocative hypothesis on the significance of LC in conditioning Parkinson tremor. In particular, I speculate that, early at a disease stage, patients with PD and tremor might have an (hyper-)active LC-NAergic system, which would play a key role in the appearance of tremor itself. Furthermore, given a putative compensatory and possibly neuroprotective mechanism of noradrenaline (NA), an intact or hyper-active NAergic system would be responsible for, and support the clinical observation of, a slower disease progression in PD patients with tremor. When verified, this hypothesis will define, for the first time at a physio-pathological level, two different clinical phenotypes (i.e. tremor dominant and akinetic-rigid PD) and possibly suggest new interventional strategies (targeting the NAergic system) to modify disease progression. A number of drugs that can modulate the NAergic system already exist, ripe for testing. There is no cure for PD, and understanding the cause and progression of the neurodegenerative process is as challenging as it is necessary.
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Grindstaff, Ryan Jerrod. "Arterial baroreceptor regulation of vasopressin release." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9974636.

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Berglöf, Elisabet. "Dopamine neurons in ventral mesencephalon : interactions with glia and locus coeruleus." Doctoral thesis, Umeå universitet, Histologi med cellbiologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1667.

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Parkinson’s disease is a progressive neurodegenerative disorder, characterized by a depletion of the dopaminergic neurons in the substantia nigra. The cause of the disease is yet unknown but age, oxidative stress, and neuroinflammation are some of the features involved in the degeneration. In addition, substantial cell death of noradrenergic neurons occurs in the locus coeruleus (LC). Noradrenaline has been suggested to protect the dopamine neurons from oxidative stress and neuroinflammation. The main treatment of Parkinson’s disease is Levo-dopa, although severe side effects arise from this therapy. Hence, grafting fetal ventral mesencephalic (VM) tissue into the adult striatum has been evaluated as an alternative treatment for Parkinsons’s disease. However, the survival of the grafted neurons is limited, and the dopamine-denervated striatum does not become fully reinnervated. Therefore, elucidating factors that enhance dopamine nerve fiber formation and/or survival of the grafted neurons is of utmost importance. To investigate dopamine nerve fiber formation and the interactions with glial cells, organotypic VM tissue cultures were utilized. Two morphologically different nerve fiber outgrowths from the tissue slice were observed. Nerve fibers were initially formed in the absence of migrating astrocytes, although thin vimentin-positive astrocytic processes were detected within the same area. A second, persistent nerve fiber outgrowth was observed associated with migrating astrocytes. Hence, both of these nerve fiber outgrowths were to some extent dependent on astrocytes, and appeared as a general feature since this phenomenon was demonstrated in β-tubulin, tyrosine hydroxylase (TH), and aldehyde dehydrogenase A1 (ALDH1)-positive nerve fibers. Neither oligodendrocytes (NG2-positive cells), nor microglia (Iba-1-positive cells) exerted any effect on these two neuronal growths. Since astrocytes appeared to influence the nerve fiber formation, the role of proteoglycans, i.e. extracellular matrix molecules produced by astrocytes, was investigated. β-xyloside was added to the cultures to inhibit proteoglycan synthesis. The results revealed a hampered astrocytic migration and proliferation, as well as a reduction of the glia-associated TH-positive nerve fiber outgrowth. Interestingly, the number of cultures displaying the non-glia-mediated TH-positive nerve fibers increased after β-xyloside treatment, although the amount of TH-protein was not altered. Thus, proteoglycans produced by astrocytes appeared to be important in affecting the dopamine nerve fiber formation. The noradrenaline neurons in LC have been suggested to protect dopamine neurons from damage. Therefore, the interaction between VM and LC was evaluated. Using the intraocular grafting method, fetal VM and LC were grafted either as single grafts or as VM+LC co-grafts. Additionally, the recipient animals received 2% blueberry-enriched diet. The direct contact of LC promoted graft volume and survival of TH-positive neurons in the VM grafts. The number of dopamine neurons, derived preferably from the A9 (ALDH1/TH-positive) was increased, whereas the dopamine neurons from the A10 (calbindin/TH-positive) were not affected. A dense dopamine-β-hydroxylase (DBH)-positive innervation was correlated to the improved survival. Blueberry-enriched diet enhanced the number of TH-positive neurons in VM, although the graft size was not altered. The combination of blueberries and the presence of LC did not yield additive effects on the survival of VM grafts. The attachment of VM or the addition of blueberries did not affect the survival of TH-positive neurons in LC grafts. The number of Iba-1-positive microglia was decreased in co-grafted VM compared to single VM transplants. The addition of blueberries reduced the number of Iba-1-positive microglia in single VM transplants. Hence, the direct contact of LC or the addition of blueberries enhanced the survival of VM grafts. Taken together, these data demonstrate novel findings regarding the importance of astrocytes for the nerve fiber formation of dopamine neurons. Further, both the direct attachment of LC or antioxidant-enriched diet promote the survival of fetal VM grafts, while LC is not affected.
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Karolewicz, Beata, Laurel Johnson, Katalin Szebeni, Craig A. Stockmeier, and Gregory A. Ordway. "Glutamate Signaling Proteins and Tyrosine Hydroxylase in the Locus Coeruleus of Alcoholics." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/8610.

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It has been postulated that alcoholism is associated with abnormalities in glutamatergic neurotransmission. This study examined the density of glutamate NMDA receptor subunits and its associated proteins in the noradrenergic locus coeruleus (LC) in deceased alcoholic subjects. Our previous research indicated that the NMDA receptor in the human LC is composed of obligatory NR1 and regulatory NR2C subunits. At synapses, NMDA receptors are stabilized through interactions with postsynaptic density protein (PSD-95). PSD-95 provides structural and functional coupling of the NMDA receptor with neuronal nitric oxide synthase (nNOS), an intracellular mediator of NMDA receptor activation. LC tissue was obtained from 10 alcohol-dependent subjects and eight psychiatrically healthy controls. Concentrations of NR1 and NR2C subunits, as well as PSD-95 and nNOS, were measured using Western blotting. In addition, we have examined tyrosine hydroxylase (TH), the rate-limiting enzyme in the synthesis of norepinephrine. The amount of NR1 was lower in the rostral (-30%) and middle (-41%) portions of the LC of alcoholics as compared to control subjects. No differences in the amounts of NR2C, PSD-95, nNOS and TH were detected comparing alcoholic to control subjects. Lower levels of NR1 subunit of the NMDA receptor in the LC implicates altered glutamate-norepinephrine interactions in alcoholism.
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Books on the topic "Locus Coeruleus"

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1935-, Barnes Charles D., Pompeiano O, Universitá di Pisa. Dipartimento di Fisiologia e Biochimica., and Washington State University. Dept. of Veterinary and Comparative Anatomy, Pharmacology, and Physiology., eds. Neurobiology of the locus coeruleus. Amsterdam: Elsevier, 1991.

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M, Briley, and Marien M, eds. Noradrenergic mechanisms in Parkinson's disease. Boca Raton, Fla: CRC Press, 1994.

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3

Lotos im alten Ägypten: Vorarbeiten zu einer Kulturgeschichte von Nymphaea lotus, Nymphaea coerulea und Nelumbo nucifera in der dynastischen Zeit. Pfaffenweiler: Centaurus-Verlagsgesellschaft, 1985.

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P, Illes, and Zimmermann Herbert 1944-, eds. Nucleotides and their receptors in the nervous system. Amsterdam: Elsevier, 1999.

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Masao, Norita, Bando Takehiko, and Stein Barry E, eds. Extrageniculostriate mechanisms underlying visually-guided orientation behavior. Amsterdam: Elsevier, 1996.

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J, Allum J. H., ed. Natural and artificial control of hearing and balance. Amsterdam: Elsevier, 1993.

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A, Nordberg, and International Symposium on Nicotinic Receptors on the CNS - Their Role in Synaptic Transmission (1988 : Uppsala, Sweden), eds. Nicotinic receptors in the CNS: Their role in synaptic transmission. Amsterdam: Elsevier, 1989.

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C, Polosa, and Weaver Lynne C. 1945-, eds. Autonomic dysfunction after spinal cord injury. Amsterdam: Elsevier, 2006.

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S, Martinez-Conde, and European Conference on Visual Perception (28th : 2005 : La Coruña, Spain), eds. Visual Perception. Amsterdam: Elsevier, 2006.

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H, Yu Albert C., ed. Neuronal-astrocytic interactions: Implications for normal and pathological CNS function. Amsterdam: Elsevier, 1992.

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Book chapters on the topic "Locus Coeruleus"

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Noggle, Chad A. "Locus Coeruleus." In Encyclopedia of Child Behavior and Development, 896. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-79061-9_1678.

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Sara, Susan J. "Selective Attention, Memory, and the Locus Coeruleus." In Brain Plasticity, Learning, and Memory, 211–17. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-5003-3_21.

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Marshall, Kenneth C., and Paul G. Finlayson. "Synaptic Regulation of Locus Coeruleus Neuronal Activity." In Neurotransmitters and Cortical Function, 373–90. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-0925-3_24.

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Velley, Lydia, Eliane Kempf, Jeanne Velly, and Bernard Cardo. "Role of the Locus Coeruleus System in Behavioral Plasticity." In Brain Plasticity, Learning, and Memory, 85–96. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-5003-3_10.

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Pompeiano, O. "Noradrenergic Locus Coeruleus Influences on Posture and Vestibulospinal Reflexes." In Alpha and Gamma Motor Systems, 429–34. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1935-5_92.

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Harley, Carolyn W., and Suzanne Evans. "Locus-Coeruleus-Induced Enhancement of the Perforant-Path Evoked Potential." In Cellular Mechanisms of Conditioning and Behavioral Plasticity, 415–23. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4757-9610-0_39.

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Weiss, Jay M., and Peter E. Simson. "Electrophysiology of the Locus Coeruleus: Implications for Stress-Induced Depression." In Animal Models of Depression, 111–34. Boston, MA: Birkhäuser Boston, 1989. http://dx.doi.org/10.1007/978-1-4684-6762-8_7.

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Mallick, Birendra Nath, Vibha Madan, and Dinesh Pal. "Locus Coeruleus and Adrenergic Modulation of Rapid Eye Movement Sleep." In Neuroendocrine Correlates of Sleep/Wakefulness, 163–78. Boston, MA: Springer US, 2006. http://dx.doi.org/10.1007/0-387-23692-9_8.

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Dünnwald, Max, Matthew J. Betts, Emrah Düzel, and Steffen Oeltze-Jafra. "Localization of the Locus Coeruleus in MRI via Coordinate Regression." In Bildverarbeitung für die Medizin 2021, 10–15. Wiesbaden: Springer Fachmedien Wiesbaden, 2021. http://dx.doi.org/10.1007/978-3-658-33198-6_5.

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Aston-Jones, Gary, Janusz Rajkowski, and Jonathan Cohen. "Role of the Locus Coeruleus-Norepinephrine System in Attention and Behavioral Flexibility." In Catecholamine Research, 357–60. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4757-3538-3_85.

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Conference papers on the topic "Locus Coeruleus"

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Dahl, Martin J., Tiantian Li, Matthew R. Nassar, Mara Mather, and Markus Werkle-Bergner. "Locus coeruleus-related insula activation supports implicit learning." In 2023 Conference on Cognitive Computational Neuroscience. Oxford, United Kingdom: Cognitive Computational Neuroscience, 2023. http://dx.doi.org/10.32470/ccn.2023.1383-0.

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Hussain, Sana, Mahsa Alizadeh Shalchy, Kimia C. Yaghoubi, Jason Langley, Xu Chen, Ilana J. Bennett, Ringo Huang, et al. "Locus Coeruleus Engagement Drives Network Connectivity Dynamics In Humans And Rats." In 2019 Conference on Cognitive Computational Neuroscience. Brentwood, Tennessee, USA: Cognitive Computational Neuroscience, 2019. http://dx.doi.org/10.32470/ccn.2019.1366-0.

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Norris, Makenzie, Chao-Cheng Kuo, Jenny Kim, Samantha Dunn, Gustavo Borges, and Jordan McCall. "Dynamic Role of Intra-Locus Coeruleus Mu Opioid Receptors in Nociception." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.246940.

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Kim, Jenny. "Social Isolation Stress Leads to Synaptic Changes in Locus Coeruleus Noradrenergic Neurons." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.540090.

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Gaspert, Anastasia, Rasmus Schülke, Tabea Bätge, Thorsten Folsche, Nima Mahmoudi, Mike Wattjes, Christopher Sinke, et al. "Functional connectivity analysis of locus coeruleus in patients with major depressive episode." In Abstracts of the 3rd Symposium of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) and Deutsche Gesellschaft für Biologische Psychiatrie (DGBP). Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0042-1757657.

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Dünnwald, Max, Philipp Ernst, Emrah Düzel, Klaus Tönnies, Matthew J. Betts, Andreas Nürnberger, and Steffen Oeltze-Jafra. "Deep Coordinate Regression for Weakly Supervised Segmentation of the Locus Coeruleus in MRI." In 2023 IEEE 36th International Symposium on Computer-Based Medical Systems (CBMS). IEEE, 2023. http://dx.doi.org/10.1109/cbms58004.2023.00259.

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Kuo, Chao-Cheng, and Jordan McCall. "Multiplexed pharmacological calcium imaging reveals distinct GPCR-mediated response profiles of locus coeruleus neurons." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.237540.

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Романова, И., Е. Михайлова, and А. Михрина. "АНАЛИЗ РАСПРЕДЕЛЕНИЯ МЕЛАНОКОРТИНОВЫХ РЕЦЕПТОРОВ 1-ГО ТИПА В НЕЙРОНАХ LOCUS COERULEUS МЫШИ С57BL/6J." In Современная нейробиология: фундаментальные исследования и практические аспекты. Baskir State University, 2022. http://dx.doi.org/10.33184/snfipa-2022-10-19.26.

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Smiley, Cora, Samantha Bouknight, Brittany Pate, Alexandria Nowicki, Evelynn Harrington, and Susan Wood. "Microglia in the Locus Coeruleus Mediate the Behavioral and Neuronal Consequences of Social Stress in Females." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.286760.

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Pineda, Joseba, Irati Rodilla, and Aitziber Mendiguren. "Functional characterization of α1 adrenergic receptor in the rat locus coeruleus in vitro." In MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd edition. Basel, Switzerland: MDPI, 2017. http://dx.doi.org/10.3390/mol2net-03-05082.

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