Journal articles on the topic 'LNK'
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Takaki, Satoshi, Julian D. Watts, Katherine A. Forbush, Nhan T. Nguyen, Jun Hayashi, Jose Alberola-Ila, Ruedi Aebersold, and Roger M. Perlmutter. "Characterization of Lnk." Journal of Biological Chemistry 272, no. 23 (June 6, 1997): 14562–70. http://dx.doi.org/10.1074/jbc.272.23.14562.
Full textkoren-Michowitz, Maya, Sigal Gery, Daniel Nowak, Arnon Nagler, Aiko Matsubara, Takayuki Tabayashi, Seishi Ogawa, and H. Phillip Koeffler. "Adaptor Protein LNK Binds to and Is Phosphorylated by JAK3 and May Serve as a Scaffold for JAK3 Autophosphorylation In the Absence of An Appropriate Cytokine Receptor." Blood 116, no. 21 (November 19, 2010): 2785. http://dx.doi.org/10.1182/blood.v116.21.2785.2785.
Full textDou, Huijuan, Andriana Kotini, Wenli Liu, Trevor Fidler, Kaori Endo-Umeda, Xiaoli Sun, Malgorzata Olszewska, et al. "Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency." Circulation 144, no. 24 (December 14, 2021): 1940–54. http://dx.doi.org/10.1161/circulationaha.121.056414.
Full textTabayashi, Takayuki, Sigal Gery, Maya Koren-Michowitz, and H. Phillip Koeffler. "Adaptor Protein Lnk Negatively Regulates Bcr-Abl-Induced Cell Proliferation through Inhibition of the Stat5 Signaling Pathway." Blood 116, no. 21 (November 19, 2010): 3406. http://dx.doi.org/10.1182/blood.v116.21.3406.3406.
Full textGery, Sigal, Saskia Gueller, Julia Sohn, Shayne Nabavinouri, Amanda Leiter, and H. Phillip Koeffler. "Adaptor Protein Lnk Negatively Regulates Mutant MPL and JAK2 Alleles Associated with Myeloproliferative Disorders." Blood 110, no. 11 (November 16, 2007): 1531. http://dx.doi.org/10.1182/blood.v110.11.1531.1531.
Full textKiladjian, Jean-Jacques, Fanny Baran-Marszak, Christophe Desterke, Bruno Cassinat, Hajer Magdoud, Elisabeth Mazoyer, Pierre Fenaux, et al. "Abnormal Expression and Function of the Lnk Adaptor Protein in Myeloproliferative Neoplasms (MPN)." Blood 114, no. 22 (November 20, 2009): 2897. http://dx.doi.org/10.1182/blood.v114.22.2897.2897.
Full textEto, Koji, Hitoshi Takizawa, Satoshi Takaki, Hidekazu Nishikii, Atsushi Oda, and Hiromitsu Nakauchi. "The Cytokine Signal Inhibitor Lnk Promotes αIIbβ3 Integrin Outside-In Signaling through β3 Tyrosine Phosphorylation in Platelets." Blood 110, no. 11 (November 16, 2007): 3651. http://dx.doi.org/10.1182/blood.v110.11.3651.3651.
Full textde Leone, María José, Carlos Esteban Hernando, Andrés Romanowski, Mariano García-Hourquet, Daniel Careno, Joaquín Casal, Matías Rugnone, Santiago Mora-García, and Marcelo Javier Yanovsky. "The LNK Gene Family: At the Crossroad between Light Signaling and the Circadian Clock." Genes 10, no. 1 (December 20, 2018): 2. http://dx.doi.org/10.3390/genes10010002.
Full textTong, Wei, Jing Zhang, and Harvey F. Lodish. "Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways." Blood 105, no. 12 (June 15, 2005): 4604–12. http://dx.doi.org/10.1182/blood-2004-10-4093.
Full textBalcerek, Joanna, Jing Jiang, Alexey Bersenev, Yiwen Song, Chao Wu, and Wei Tong. "14-3-3 Regulates the Lnk/JAK2 Pathway In Hematopoietic Stem and Progenitor Cells." Blood 116, no. 21 (November 19, 2010): 86. http://dx.doi.org/10.1182/blood.v116.21.86.86.
Full textLin, De-Chen, Tong Yin, Maya Koren-Michowitz, Ling-Wen Ding, Saskia Gueller, Sigal Gery, Takayuki Tabayashi, et al. "Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3." Blood 120, no. 16 (October 18, 2012): 3310–17. http://dx.doi.org/10.1182/blood-2011-10-388611.
Full textNobuhisa, Ikuo, Makiko Takizawa, Satoshi Takaki, Hirofumi Inoue, Keisuke Okita, Masaya Ueno, Kiyoshi Takatsu, and Tetsuya Taga. "Regulation of Hematopoietic Development in the Aorta-Gonad-Mesonephros Region Mediated by Lnk Adaptor Protein." Molecular and Cellular Biology 23, no. 23 (December 1, 2003): 8486–94. http://dx.doi.org/10.1128/mcb.23.23.8486-8494.2003.
Full textLasho, Terra, Ayalew Tefferi, Alessandro M. Vannucchi, Christy Finke, Paola Guglielmelli, Lisa Pieri, and Animesh Pardanani. "LNK Mutation Studies In Chronic- and Blast-Phase Myeloproliferative Neoplasms and JAK2 Mutation-Negative Erythrocytosis." Blood 116, no. 21 (November 19, 2010): 4105. http://dx.doi.org/10.1182/blood.v116.21.4105.4105.
Full textVelazquez, Laura, Alec M. Cheng, Heather E. Fleming, Caren Furlonger, Shirly Vesely, Alan Bernstein, Christopher J. Paige, and Tony Pawson. "Cytokine Signaling and Hematopoietic Homeostasis Are Disrupted in Lnk-deficient Mice." Journal of Experimental Medicine 195, no. 12 (June 17, 2002): 1599–611. http://dx.doi.org/10.1084/jem.20011883.
Full textHao, Meihua, Feng Yuan, Chenchen Jin, Zehong Zhou, Qi Cao, Ling Xu, Guanlei Wang, et al. "Overexpression of Lnk in the Ovaries Is Involved in Insulin Resistance in Women With Polycystic Ovary Syndrome." Endocrinology 157, no. 10 (July 26, 2016): 3709–18. http://dx.doi.org/10.1210/en.2016-1234.
Full textSimon, Clotilde, Elisabetta Dondi, Amandine Chaix, Paulo de Sepulveda, Terrance J. Kubiseski, Nadine Varin-Blank, and Laura Velazquez. "Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells." Blood 112, no. 10 (November 15, 2008): 4039–47. http://dx.doi.org/10.1182/blood-2008-05-154849.
Full textGueller, Saskia, Helen S. Goodridge, Hongtao Xing, Sigal Gery, Hubert Serve, and H. Phillip Koeffler. "Adaptor Protein Lnk Inhibits C-Fms Mediated Macrophage Function." Blood 112, no. 11 (November 16, 2008): 3555. http://dx.doi.org/10.1182/blood.v112.11.3555.3555.
Full textGueller, Saskia, Sigal Gery, Verena Nowak, Liqin Liu, Hubert Serve, and H. Phillip Koeffler. "Adaptor protein Lnk associates with Tyr568 in c-Kit." Biochemical Journal 415, no. 2 (September 25, 2008): 241–45. http://dx.doi.org/10.1042/bj20080102.
Full textEto, Koji, Hitoshi Takizawa, Hidekazu Nishikii, Jun Seita, Atsushi Oda, Noriko Tamura, Shinya Goto, Kiyoshi Takatsu, Satoshi Takaki, and Hiromitsu Nakauchi. "Negative Hematopoietic Scaffold Lnk Upregulates Integrin Outside-In Signaling in Platelets." Blood 106, no. 11 (November 16, 2005): 382. http://dx.doi.org/10.1182/blood.v106.11.382.382.
Full textGery, Sigal, Saskia Gueller, Katya Chumakova, Norihiko Kawamata, Liqin Liu, and H. Phillip Koeffler. "Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders." Blood 110, no. 9 (November 1, 2007): 3360–64. http://dx.doi.org/10.1182/blood-2007-05-089326.
Full textTakizawa, Hitoshi, Chiyomi Kubo-Akashi, Ikuo Nobuhisa, Sang-Mo Kwon, Masanori Iseki, Tetsuya Taga, Kiyoshi Takatsu, and Satoshi Takaki. "Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk." Blood 107, no. 7 (April 1, 2006): 2968–75. http://dx.doi.org/10.1182/blood-2005-05-2138.
Full textTong, Wei, and Harvey F. Lodish. "Lnk Inhibits Tpo–mpl Signaling and Tpo-mediated Megakaryocytopoiesis." Journal of Experimental Medicine 200, no. 5 (August 30, 2004): 569–80. http://dx.doi.org/10.1084/jem.20040762.
Full textPérez-García, Pablo, Yuan Ma, Marcelo J. Yanovsky, and Paloma Mas. "Time-dependent sequestration of RVE8 by LNK proteins shapes the diurnal oscillation of anthocyanin biosynthesis." Proceedings of the National Academy of Sciences 112, no. 16 (April 6, 2015): 5249–53. http://dx.doi.org/10.1073/pnas.1420792112.
Full textYano, Mio, Toshihiko Imamura, Kenichi Sakamoto, Daisuke Asai, Gen Kano, Hajime Hosoi, Takao Deguchi, et al. "Clinical Significance of LNK (SH2B3) Expression in Pediatric B Cell Precursor Acute Lymphoblastic Leukemia." Blood 124, no. 21 (December 6, 2014): 3772. http://dx.doi.org/10.1182/blood.v124.21.3772.3772.
Full textKomartin, Raluca Sanda, Brindusa Balanuca, Madalina Ioana Necolau, Anca Cojocaru, and Raluca Stan. "Composite Materials from Renewable Resources as Sustainable Corrosion Protection Coatings." Polymers 13, no. 21 (November 2, 2021): 3792. http://dx.doi.org/10.3390/polym13213792.
Full textBaran-Marszak, Fanny, Hajer Magdoud, Christophe Desterke, Anabell Alvarado, Claudine Roger, Stéphanie Harel, Elizabeth Mazoyer, et al. "Expression level and differential JAK2-V617F–binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms." Blood 116, no. 26 (December 23, 2010): 5961–71. http://dx.doi.org/10.1182/blood-2009-12-256768.
Full textMorris, Rhiannon, Liesl Butler, Andrew Perkins, Nadia J. Kershaw, and Jeffrey J. Babon. "The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis." Pharmaceuticals 15, no. 1 (December 24, 2021): 24. http://dx.doi.org/10.3390/ph15010024.
Full textKoren-Michowitz, Maya, Sigal Gery, Daniel Nowak, and Phillip H. Koeffler. "Adaptor Protein Lnk Binds to JAK3 and Negatively Regulates a Mutant Activating Allele Associated with Megakaryocytic Leukemia." Blood 114, no. 22 (November 20, 2009): 5044. http://dx.doi.org/10.1182/blood.v114.22.5044.5044.
Full textLin, Dechen, Tong Yin, Maya koren-Michowitz, Ling-Wen Ding, Saskia Gueller, Sigal Gery, Takayuki Tabayashi, et al. "Adaptor Protein Lnk Binds to and Inhibits Normal and Leukemic FLT3." Blood 120, no. 21 (November 16, 2012): 1312. http://dx.doi.org/10.1182/blood.v120.21.1312.1312.
Full textBersenev, Alexey, Chao Wu, Joanna Balcerek, and Wei Tong. "Lnk Constrains Oncogenic JAK2-Induced Myeloproliferative Disease in Mice." Blood 114, no. 22 (November 20, 2009): 1437. http://dx.doi.org/10.1182/blood.v114.22.1437.1437.
Full textCheng, Ying, Kudakwashe Chikwava, Chao Wu, Anchit Bhagat, John K. Choi, and Wei Tong. "LNK (SH2B3) Synergizes with TP53 in Suppressing B-Precursor Acute Lymphoblastic Leukemia through IL-7 Receptor Signaling." Blood 124, no. 21 (December 6, 2014): 1074. http://dx.doi.org/10.1182/blood.v124.21.1074.1074.
Full textBersenev, Alexey, Chao Wu, Joanna Balcerek, and Wei Tong. "Lnk Controls Hematopoietic Stem Cell Self-Renewal through Direct Interactions with JAK2 and Contributes to Oncogenic JAK2-Induced Myeloproliferative Diseases in Mice." Blood 112, no. 11 (November 16, 2008): 895. http://dx.doi.org/10.1182/blood.v112.11.895.895.
Full textHoldreith, Nicholas, Grace Lee, Vemika Chandra, Carlo Salas Salinas, Peter Nicholas, Timothy S. Olson, and Wei Tong. "LNK (SH2B3) inhibition expands healthy and Fanconi anemia human hematopoietic stem and progenitor cells." Blood Advances 6, no. 3 (January 27, 2022): 731–45. http://dx.doi.org/10.1182/bloodadvances.2021004205.
Full textMatsumoto, Tomoyuki, Masaaki Ii, Hiromi Nishimura, Taro Shoji, Yutaka Mifune, Atsuhiko Kawamoto, Ryosuke Kuroda, et al. "Lnk-dependent axis of SCF–cKit signal for osteogenesis in bone fracture healing." Journal of Experimental Medicine 207, no. 10 (September 20, 2010): 2207–23. http://dx.doi.org/10.1084/jem.20100321.
Full textGueller, Saskia, Sigal Gery, and H. Phillip Koeffler. "Adaptor Protein Lnk Binds to PDGFRA, PDGFRB and FIP1L1-PDGFRA, but Not to the TEL-PDGFRB Fusion Protein." Blood 110, no. 11 (November 16, 2007): 2213. http://dx.doi.org/10.1182/blood.v110.11.2213.2213.
Full textTakaki, Satoshi, Hatsue Morita, Yoshinari Tezuka, and Kiyoshi Takatsu. "Enhanced Hematopoiesis by Hematopoietic Progenitor Cells Lacking Intracellular Adaptor Protein, Lnk." Journal of Experimental Medicine 195, no. 2 (January 14, 2002): 151–60. http://dx.doi.org/10.1084/jem.20011170.
Full textBunting, Kevin D. "Another Lnk to STAT activation." Blood 116, no. 6 (August 12, 2010): 862–64. http://dx.doi.org/10.1182/blood-2010-05-283176.
Full textMcMullin, Mary Frances, and Holger Cario. "LNK mutations and myeloproliferative disorders." American Journal of Hematology 91, no. 2 (January 22, 2016): 248–51. http://dx.doi.org/10.1002/ajh.24259.
Full textWang, Wei, Yang Tang, Ying Wang, Joanna Balcerek, Wei Tong, Ross L. Levine, Carrie Welch, Alan Tall, and Nan Wang. "SH2B3/LNK Loss of Function Promotes Atherosclerosis and Thrombosis." Blood 126, no. 23 (December 3, 2015): 3443. http://dx.doi.org/10.1182/blood.v126.23.3443.3443.
Full textOh, Stephen T., Jacob M. Zahn, Carol D. Jones, Bing Zhang, Mignon L. Loh, Hagop Kantarjian, Erin F. Simonds, et al. "Identification of Novel LNK Mutations In Patients with Chronic Myeloproliferative Neoplasms and Related Disorders." Blood 116, no. 21 (November 19, 2010): 315. http://dx.doi.org/10.1182/blood.v116.21.315.315.
Full textRumi, Elisa, Ashot S. Harutyunyan, Daniela Pietra, Jelena D. Milosevic Feenstra, Chiara Cavalloni, Elisa Roncoroni, Ilaria Casetti, et al. "LNK mutations in familial myeloproliferative neoplasms." Blood 128, no. 1 (July 7, 2016): 144–45. http://dx.doi.org/10.1182/blood-2016-04-711150.
Full textBersenev, Alexey, Chao Wu, Joanna Balcerek, Jiang Jing, Mondira Kundu, Gerd A. Blobel, Kudakwashe R. Chikwava, and Wei Tong. "Lnk constrains myeloproliferative diseases in mice." Journal of Clinical Investigation 120, no. 6 (June 1, 2010): 2058–69. http://dx.doi.org/10.1172/jci42032.
Full textNorddahl, Gudmundur L., Martin Wahlestedt, Santiago Gisler, Mikael Sigvardsson, and David Bryder. "Enhanced Cytokine Responsiveness Counteracts Age-Induced Decline in Hematopoietic Stem Cell Function." Blood 118, no. 21 (November 18, 2011): 2342. http://dx.doi.org/10.1182/blood.v118.21.2342.2342.
Full textOh, Stephen T., Erin F. Simonds, Carol Jones, Matthew B. Hale, Yury Goltsev, Kenneth D. Gibbs, Jason D. Merker, James L. Zehnder, Garry P. Nolan, and Jason Gotlib. "Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms." Blood 116, no. 6 (August 12, 2010): 988–92. http://dx.doi.org/10.1182/blood-2010-02-270108.
Full textEma, Hideo, Jun Seita, Jun Ooehara, Akiko Iseki, Hina Takano, and Hiromitsu Nakauchi. "Adaptor Protein Lnk Negatively Controls the Likelihood of Self-Renewal in Hematopoietic Stem Cells." Blood 108, no. 11 (November 16, 2006): 1316. http://dx.doi.org/10.1182/blood.v108.11.1316.1316.
Full textVila González, Patricia Elizabet, and María Noel Pereyra. "Interpretación a partir del análisis cinético de los resultados del ensayo acelerado (IRAM 1674) para la reacción álcali-sílice pavimentos." Métodos y Materiales 7 (May 22, 2018): 1–10. http://dx.doi.org/10.15517/mym.v7i1.29716.
Full textBalcerek, Joanna, Jing Jiang, Qinqin Jiang, Kaosheng Lyu, Roger Greenberg, and Wei Tong. "LNK (SH2B3) Deficiency Ameliorates Hematopoietic Stem Cell Defects in Fanconi Anemi." Blood 128, no. 22 (December 2, 2016): 2670. http://dx.doi.org/10.1182/blood.v128.22.2670.2670.
Full textChen, Jingbo, Jiawen Xu, Yan Sun, Yuhuan Xue, Yang Zhao, Dongzi Yang, Shuijie Li, and Xiaomiao Zhao. "Gut Microbiota Dysbiosis Ameliorates in LNK-Deficient Mouse Models with Obesity-Induced Insulin Resistance Improvement." Journal of Clinical Medicine 12, no. 5 (February 22, 2023): 1767. http://dx.doi.org/10.3390/jcm12051767.
Full textDale, Bethany L., and Meena S. Madhur. "Linking inflammation and hypertension via LNK/SH2B3." Current Opinion in Nephrology and Hypertension 25, no. 2 (March 2016): 87–93. http://dx.doi.org/10.1097/mnh.0000000000000196.
Full textDing, L.-W., Q.-Y. Sun, D.-C. Lin, W. Chien, N. Hattori, X.-M. Dong, S. Gery, et al. "LNK (SH2B3): paradoxical effects in ovarian cancer." Oncogene 34, no. 11 (April 7, 2014): 1463–74. http://dx.doi.org/10.1038/onc.2014.34.
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