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1
Lester, Krystal L. "Characterisation of Oncogenic LMO Transcriptional complexes." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13754.
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The LIM only (LMO) family of proteins are transcriptional regulators that are critical for the regulation of many developmental processes. In early red blood cell development one family member, LMO2, regulates blood cell development (erythropoiesis) through involvement in a transcriptional complex that also contains Tal1, E2a proteins, Gata1 and LDB1. Two components of this complex, Tal1 and LMO2, along with their homologues Lyl1, LMO1 and LMO3, are oncogenes in T cell acute lymphoblastic leukaemia (T ALL). Complexes similar to the erythropoietic LMO2 transcriptional complex are thought to drive the onset of T ALL. This thesis investigates the protein protein interactions of potential constituents of both normal and oncogenic complexes. A full set of tethered LMO-LDB1 sub-complexes was designed, generated, purified and characterised using SEC/MALLS, CD spectropolarimetry and 1D 1H-NMR. The proteins were folded, predominantly monomeric and may be more stable than previously generated versions. Attempts to crystallise the previously uncharacterised LMO1-LDB1 and LMO3-LDB1 constructs are described. GST-pulldown and EMSA experiments were used to show that LMO1–3-LDB1 but not LMO4 LDB1 can bind to Tal1 E2a and Lyl1 E2a heterodimers in the absence of DNA and to characterise heterodimer DNA binding of the higher order complex. These data indicate that the bHLH proteins likely undergo dimer exchange, such that in the presence of DNA, Tal1 E2a proteins form substantial amounts of homodimers as well as heterodimers, but heterodimer formation is favoured by interaction with LMO-LDB1 proteins. No evidence of Lyl1 E2a heterodimer formation on DNA was observed by EMSA, but this heterodimer was stabilised through higher order complex formation with LMO2-LDB1. Binding affinities of LMO1–4-LDB1 to Tal1 E2a heterodimers indicate no binding by LMO4 and similar levels of binding for LMO1–3-LDB1. A protein engineering approach was thus used to generate more stable extended Tal1 E2a constructs, which would be useful for further characterisation of these interactions. Finally, it was shown that Gata2 and Gata3 bind with similar, but slightly lower affinity to LMO2. Also, only the C-terminal finger of Gata1 shows appreciable independent binding to DNA containing GATC/G motifs. The implications of this data for the mechanisms of transcriptional complex formation, and how variant complexes can up- and down-regulate different sets of genes throughout normal development and T-cell leukaemia are discussed.
2
Dong, Wei-Feng. "Expression and regulation of rhombotin-2 (RBTN/LMO-2) in normal hematopoiesis and leukemogenesis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/NQ53807.pdf.
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Kwan, Ann Hau Yu. "Protein Design Based on a PHD Scaffold." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/564.
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The plant homeodomain (PHD) is a protein domain of ~45�100 residues characterised by a Cys4-His-Cys3 zinc-binding motif. When we commenced our study of the PHD in 2000, it was clear that the domain was commonly found in proteins involved in transcription. Sequence alignments indicate that while the cysteines, histidine and a few other key residues are strictly conserved, the rest of the domain varies greatly in terms of both amino acid composition and length. However, no structural information was available on the PHD and little was known about its function. We were therefore interested in determining the structure of a PHD in the hope that this might shed some light on its function and molecular mechanism of action. Our work began with the structure determination of a representative PHD, Mi2b-P2, and this work is presented in Chapter 3. Through comparison of this structure with the two other PHD structures that were determined during the course of our work, it became clear that PHDs adopt a well-defined globular fold with a superimposable core region. In addition, PHDs contain two loop regions (termed L1 and L3) that display increased flexibility and overlay less well between the three PHD structures available. These L1 and L3 regions correspond to variable regions identified earlier in PHD sequence alignments, indicating that L1 and L3 are probably not crucial for the PHD fold, but are instead likely to be responsible for imparting function(s) to the PHD. Indeed, numerous recent functional studies of PHDs from different proteins have since demonstrated their ability in binding a range of other proteins. In order to ascertain whether or not L1 and L3 were in fact dispensable for folding, we made extensive mutations (including both insertions and substitutions) in the loop regions of Mi2b-P2 and showed that the structure was maintained. We then went on to illustrate that a new function could be imparted to Mi2b-P2 by inserting a five-residue CtBP-binding motif into the L1 region and showed this chimera could fold and bind CtBP. Having established that the PHD could adopt a new binding function, we next sought to use combinatorial methods to introduce other novel functions into the PHD scaffold. Phage display was selected for this purpose, because it is a well-established technique and has been used successfully to engineer zinc-binding domains by other researchers. However, in order to establish this technique in our laboratory, we first chose a control system in which two partner proteins were already known to interact in vitro. We chose the protein complex formed between the transcriptional regulators LMO2 and ldb1 as a test case. We have examined this interaction in detail in our laboratory, and determined its three-dimensional structure. Furthermore, inappropriate formation of this complex is implicated in the onset of T-cell acute lymphoblastic leukemia. We therefore sought to use phage display to engineer ldb1 mimics that could potentially compete against wild-type ldb1 for LMO2, and this work is described in Chapter 4. Using a phage library containing ~3 x 10 7 variants of the LMO2-binding region of ldb1, we isolated mutants that were able to interact with LMO2 with higher affinity and specificity than wild-type ldb1. These ldb1 mutants represent a first step towards finding potential therapeutics for treating LMO-associated diseases. Having established phage display in our laboratory, we went on to search for PHD mutants that could bind selected target proteins. This work is described in Chapter 5. We created three PHD libraries with eight randomized residues in each of L1, L3 or in both loops of the PHD. These PHD libraries were then screened against four target proteins. After four rounds of selection, we were able to isolate a PHD mutant (dubbed L13-FH6) that could bind our test protein Fli-ets. This result demonstrates that a novel function can be imparted to the PHD using combinatorial methods and opens the way for further work in applying the PHD scaffold to other protein design work. In summary, the work detailed in Chapters 3 and 5 demonstrates that the PHD possesses many of the properties that are desirable for a protein scaffold for molecular recognition, including small size, stability, and a well-characterised structure. Moreover, the PHD motif possesses two loops (L1 and L3) of substantial size that can be remodeled for target binding. This may lead to an enhancement of binding affinities and specificities over other small scaffolds that have only one variable loop. In light of the fact that PHDs are mainly found in nuclear proteins, it is reasonable to expect that engineered PHDs could be expressed and function in an intracellular environment, unlike many other scaffolds that can only function in an oxidizing environment. Therefore, our results together with other currently available genomic and functional information indicate PHD is an excellent candidate for a scaffold that could be used to modify cellular processes. Appendices 1 and 2 describe completed bodies of work on unrelated projects that I have carried out during the course of my PhD candidature. The first comprises the invention and application of DNA sequences that contain all N-base sequences in the minimum possible length. This work is presented as a reprint of our recently published paper in Nucleic Acids Research. The second Appendix describes our structural analysis of an antifreeze protein from the shorthorn sculpin, a fish that lives in the Arctic and Antarctic oceans. This work is presented as a manuscript that is currently under review at the Journal of the American Chemical Society.
4
Kwan, Ann Hau Yu. "Protein Design Based on a PHD Scaffold." University of Sydney. Molecular and Microbial Biosciences, 2004. http://hdl.handle.net/2123/564.
Full textAbstract:
The plant homeodomain (PHD) is a protein domain of ~45�100 residues characterised by a Cys4-His-Cys3 zinc-binding motif. When we commenced our study of the PHD in 2000, it was clear that the domain was commonly found in proteins involved in transcription. Sequence alignments indicate that while the cysteines, histidine and a few other key residues are strictly conserved, the rest of the domain varies greatly in terms of both amino acid composition and length. However, no structural information was available on the PHD and little was known about its function. We were therefore interested in determining the structure of a PHD in the hope that this might shed some light on its function and molecular mechanism of action. Our work began with the structure determination of a representative PHD, Mi2b-P2, and this work is presented in Chapter 3. Through comparison of this structure with the two other PHD structures that were determined during the course of our work, it became clear that PHDs adopt a well-defined globular fold with a superimposable core region. In addition, PHDs contain two loop regions (termed L1 and L3) that display increased flexibility and overlay less well between the three PHD structures available. These L1 and L3 regions correspond to variable regions identified earlier in PHD sequence alignments, indicating that L1 and L3 are probably not crucial for the PHD fold, but are instead likely to be responsible for imparting function(s) to the PHD. Indeed, numerous recent functional studies of PHDs from different proteins have since demonstrated their ability in binding a range of other proteins. In order to ascertain whether or not L1 and L3 were in fact dispensable for folding, we made extensive mutations (including both insertions and substitutions) in the loop regions of Mi2b-P2 and showed that the structure was maintained. We then went on to illustrate that a new function could be imparted to Mi2b-P2 by inserting a five-residue CtBP-binding motif into the L1 region and showed this chimera could fold and bind CtBP. Having established that the PHD could adopt a new binding function, we next sought to use combinatorial methods to introduce other novel functions into the PHD scaffold. Phage display was selected for this purpose, because it is a well-established technique and has been used successfully to engineer zinc-binding domains by other researchers. However, in order to establish this technique in our laboratory, we first chose a control system in which two partner proteins were already known to interact in vitro. We chose the protein complex formed between the transcriptional regulators LMO2 and ldb1 as a test case. We have examined this interaction in detail in our laboratory, and determined its three-dimensional structure. Furthermore, inappropriate formation of this complex is implicated in the onset of T-cell acute lymphoblastic leukemia. We therefore sought to use phage display to engineer ldb1 mimics that could potentially compete against wild-type ldb1 for LMO2, and this work is described in Chapter 4. Using a phage library containing ~3 x 10 7 variants of the LMO2-binding region of ldb1, we isolated mutants that were able to interact with LMO2 with higher affinity and specificity than wild-type ldb1. These ldb1 mutants represent a first step towards finding potential therapeutics for treating LMO-associated diseases. Having established phage display in our laboratory, we went on to search for PHD mutants that could bind selected target proteins. This work is described in Chapter 5. We created three PHD libraries with eight randomized residues in each of L1, L3 or in both loops of the PHD. These PHD libraries were then screened against four target proteins. After four rounds of selection, we were able to isolate a PHD mutant (dubbed L13-FH6) that could bind our test protein Fli-ets. This result demonstrates that a novel function can be imparted to the PHD using combinatorial methods and opens the way for further work in applying the PHD scaffold to other protein design work. In summary, the work detailed in Chapters 3 and 5 demonstrates that the PHD possesses many of the properties that are desirable for a protein scaffold for molecular recognition, including small size, stability, and a well-characterised structure. Moreover, the PHD motif possesses two loops (L1 and L3) of substantial size that can be remodeled for target binding. This may lead to an enhancement of binding affinities and specificities over other small scaffolds that have only one variable loop. In light of the fact that PHDs are mainly found in nuclear proteins, it is reasonable to expect that engineered PHDs could be expressed and function in an intracellular environment, unlike many other scaffolds that can only function in an oxidizing environment. Therefore, our results together with other currently available genomic and functional information indicate PHD is an excellent candidate for a scaffold that could be used to modify cellular processes. Appendices 1 and 2 describe completed bodies of work on unrelated projects that I have carried out during the course of my PhD candidature. The first comprises the invention and application of DNA sequences that contain all N-base sequences in the minimum possible length. This work is presented as a reprint of our recently published paper in Nucleic Acids Research. The second Appendix describes our structural analysis of an antifreeze protein from the shorthorn sculpin, a fish that lives in the Arctic and Antarctic oceans. This work is presented as a manuscript that is currently under review at the Journal of the American Chemical Society.
5
Vera, Arboleda Anderson Arley. "Homomorphismes de type Johnson pour les surfaces et invariant perturbatif universel des variétés de dimension trois." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAD009/document.
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Soit Σ une surface compacte connexe orientée avec une seule composante du bord. Notons par M le groupe d'homéotopie de Σ. En considérant l'action de M sur le groupe fondamental de Σ, il est possible de définir différentes filtrations de M ainsi que des homomorphismes sur chaque terme de ces filtrations. Le but de cette thèse est double. En premier lieu, nous étudions deux filtrations de M : la " filtration de Johnson-Levine " introduite par Levine et la " filtration de Johnson alternative " introduite recemment par Habiro et Massuyeau. Les définitions de ces deux filtrations prennent en compte un corps en anses bordé par la surface. Nous nous référons à ces filtrations comme " filtrations de type Johnson " et les homomorphismes correspondants sont appelés " homomorphismes de type Johnson " par leur analogie avec la filtration de Johnson originale et les homomorphismes de Johnson usuels. Nous donnons une comparaison de la filtration de Johnson avec la filtration de Johnson-Levine au niveau du monoïde des cobordismes d'homologie de Σ. Nous donnons également une comparaison entre la filtration de Johnson alternative, la filtration Johnson-Levine et la filtration de Johnson au niveau du groupe d'homéotopie. Deuxièmement, nous étudions la relation entre les " homomorphismes de type Johnson" et l'extension fonctorielle de l'invariant perturbatif universel des variétés de dimension trois (l'invariant de Le-Murakami-Ohtsuki ou invariant LMO). Cette extension fonctorielle s'appelle le foncteur LMO et il prend ses valeurs dans une catégorie de diagrammes. Nous démontrons que les "homomorphismes de type Johnson " peuvent être lus dans la réduction arborée du foncteur LMO. En particulier, cela fournit une nouvelle grille de lecture de la réduction arborée du foncteur LMO<br>Let Σ be a compact oriented surface with one boundary component and let M denote the mapping class group of Σ. By considering the action of M on the fundamental group of Σ it is possible to define different filtrations of M together with some homomorphisms on each term of the filtrations. The aim of this thesis is twofold. First, we study two filtrations of M : the « Johnson-Levine filtration » introduced by Levine and « the alternative Johsnon filtration » introduced recently by Habiro and Massuyeau. The definition of both filtrations involve a handlebody bounded by Σ. We refer to these filtrations as ≪ Johnson-type filtrations » and the corresponding homomorphisms have referred to as « Johnson-type homomorphisms » by their analogy with the original Johnson filtration and the usual Johnson homomorphisms. We provide a comparison of the Johnson filtration with the Johnson-Levine filtration at the level of the monoid of homology cobordisms of Σ. We also provide a comparison of the alternative Johnson filtration with the Johnson-Levine filtration and the Johnson filtration at the level of the mapping class group. Secondly, we study the relationship between the « Johnson-type homomorphisms » and the functorial extension of the universal perturbative invariant of 3-manifolds (the Le-Murakami-Ohtsuki invariant or LMO invariant). This functorial extension is calling the LMO functor and it takes values in a category of diagrams. We prove that the « Johnson-type homomorphisms » is in the tree reduction of the LMO functor. In particular, this provides a new reading grid of the tree reduction of the LMO functor
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Gieu, Jean-Baptiste. "Étude des interfaces électrode/électrolyte des batteries lithium-ion : cas de l'électrode à base de Li4Ti5O12." Thesis, Pau, 2016. http://www.theses.fr/2016PAUU3043/document.
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Les batteries lithium-ion (Li-ion) sont privilégiées dans de nombreuses applications comme solution de stockage de l’énergie. Le composé Li4Ti5O12 (LTO) est une alternative au graphite qui demeure majoritairement utilisé comme matériau d’électrode négative dans les batteries Li-ion. Pour de potentielles applications à haute température, il est nécessaire d’étudier les couches interfaciales qui se forment dans ces conditions en surface des électrodes LTO. En effet, la formation de telles couches est un phénomène commun aux batteries Li-ion, dont la maîtrise revêt un rôle fondamental pour l’obtention de bonnes performances électrochimiques. La surface des électrodes LTO a pour cela été principalement caractérisée par Spectroscopie Photoélectronique à rayonnement X (XPS) et des analyses complémentaires ont aussi été ponctuellement menées en microscopie Auger à balayage (Scanning Auger Microscopy : SAM) pour l’acquisition de cartographies élémentaires et en spectrométrie de masse d’ions secondaires à temps de vol (Time-of-Flight Secondary Ions Spectrometry : ToF-SIMS) pour établir des profils de concentration élémentaires et moléculaires en profondeur. Ces résultats ont été systématiquement confrontés aux données électrochimiques. L’influence de différents paramètres sur les propriétés de la couche interfaciale formée en cyclage face au lithium a été évaluée. Une comparaison des couches interfaciales formées au premier cycle à température ambiante, 60 °C et 85 °C a ainsi montré qu’une température de cyclage plus élevée favorise la formation d’une couche interfaciale plus épaisse. L’utilisation d’un électrolyte contenant l’additif VC accélère la formation d’une SEI plus épaisse dès le premier cycle, moins sujette au phénomène de dissolution au cours de la délithiation et susceptible d'améliorer la rétention de capacité en longs cyclages. La substitution du sel de lithium LiPF6 par le sel LiTFSI entraîne la formation d’une couche plus fine, ce qui est principalement dû à une quantité de LiF déposée plus faible. De manière similaire, la substitution des solvants EC:DMC par les solvants PC:EMC, induit la formation d’une couche plus fine, du fait d’une quantité moins importante de LiF déposée. Par ailleurs, plus la surface spécifique de l’additif carboné entrant dans la composition des électrodes est élevée, plus la part de LiF parmi les espèces de la couche interfaciale formée est élevée, sans que cela n’influence son épaisseur. Puis, le comportement des interfaces électrode/électrolyte dans une batterie LiMn2O4/Li4Ti5O12 a finalement été étudié. Une couche interfaciale se forme en surface des deux électrodes. Néanmoins la couche formée sur l’électrode positive est plus fine que celle formée sur l’électrode négative. Leur composition est similaire, à l’exception du composé MnF2 uniquement détecté sur l’électrode négative et provenant d’un phénomène de dissolution du matériau LiMn2O4. Un prolongement de ce travail peut être envisagé concernant des électrodes à base de particules LTO avec différents coatings. De plus, une synergie systématique entre les trois techniques utilisées dans cette thèse pourra être encouragée<br>Lithium-ion (Li-ion) batteries have been considered as the solution of choice for energy storage in numerous applications. Li4Ti5O12 (LTO) compound is an alternative to the widely used graphite, as a negative electrode material. For potential high temperature applications, the study of interfacial layers formed on top of LTO electrodes in such conditions is a necessary step. The formation of such surface layers is commonly observed in lithium-ion batteries and their properties are critical for maintaining good batteries performances. Therefore, LTO electrodes surfaces were mainly analyzed by X-ray Photoelectron Spectroscopy (XPS) and complementary measurements were performed by Scanning Auger Microscopy (SAM) for the acquisition of elemental mappings and by Time-of-Flight Secondary Ions Spectrometry (ToF-SIMS) for depth profile analysis. Surface analysis results were systematically linked to electrochemical data. The influence of several parameters was investigated for LTO electrodes cycled versus lithium. The comparison of surface layers formed during the first cycle at room temperature, 60 °C and 85 °C showed that higher cycling temperatures induce the formation of a thicker layer. The use of a VC-containing electrolyte accelerates the formation of a thicker layer since the first cycle, less prone to dissolution during delithiation and susceptible to enhance the capacity retention for long cycling. Substitution of LiPF6 lithium salt by LiTFSI leads to the formation of thinner layer, which is mainly due to a lower amount of deposited LiF. Similar results are obtained for the substitution of EC:DMC solvants by PC:EMC. Furthermore, the higher the specific surface of the electrode carbonaceous additive is, the higher the share of LiF in the interfacial layer composition is, even if its thickness remains similar. Finally, the behavior of electrode/electrolyte interfaces was studied in a LiMn2O4 /Li4Ti5O12 full cell. Interfacial layers are formed on the surface of both electrodes. Nevertheless, the layer on the positive electrode is thinner than the one on the negative electrode. Their composition are similar except for MnF2 compound, coming from LiMn2O4 dissolution at the positive electrode, which is only detected on the negative electrode. This work could be continued with the study of electrodes based on coated LTO particles. Moreover, a greater synergy between three characterization techniques used in this work could be promoted
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Zerrouki, Alan. "Compréhension et Optimisation du Procédé de Dépôt par Électrophorèse en Mode Pulsé en Milieu Aqueux de Nanoparticules Modèles et d'Intérêt Industriel." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. http://www.theses.fr/2024UBFCK010.
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Ce travail de thèse s’inscrit dans le cadre d’une problématique industrielle visant à réaliser par voie électrophorétique des dépôts d’épaisseur micrométrique de matériaux d’électrodes de batterie au lithium. En raison de contraintes posées par l’utilisation de solvants organiques pour formuler à grande échelle des suspensions de nanoparticules céramiques, le procédé EPD (ElectroPhoretic Deposition) envisagé dans le contexte de ce travail fait appel à des suspensions colloïdales en milieu aqueux, ainsi qu’à une polarisation en régime pulsé afin de limiter le phénomène d’électrolyse de l’eau néfaste à l’obtention de dépôts denses.L’objectif de cette étude est d’optimiser le procédé EPD en termes de vitesse et de qualité de dépôt, en faisant appel à des suspensions modèles de nanoparticules de silice. Ainsi les conditions de synthèse de ces particules obtenues par la méthode Stöber ont été optimisées pour conférer aux nanoparticules des caractéristiques géométriques et physico-chimiques (potentiel zêta, point isoélectrique) très similaires aux nanomatériaux d’intérêt industriel.Les cinétiques de dépôt par EPD ont été simulées à travers un premier modèle par éléments finis et comparées à des retours d’expériences tant sur les suspensions monodisperses de nanoparticules de silice que sur des suspensions polydisperses de matériaux d’électrodes d’intérêt industriel. Un second modèle électrochimique a permis de simuler l’évolution du pH en surface d’électrode en régime pulsé et d’apporter une meilleure compréhension du procédé. L’hypothèse d’un mécanisme étendu de la théorie DLVO incluant une diminution du pH résultant de l’oxydation de l’eau a été mis en évidence dans le domaine des basses fréquences du régime pulsé. De plus, il a été montré que cette acidification peut être limitée en diminuant la valeur du rapport cyclique, donc en augmentant la période de relaxation du potentiel en régime pulsé, et en opérant à hautes fréquences (f > 1000 Hz).Finalement, une attention particulière a été portée sur la fissuration des dépôts qui intervient au cours de l’étape de séchage. L’utilisation de suspensions modèles polydisperses ou de conditions de séchage à humidité relative élevée ont permis d’améliorer la qualité des dépôts sans pour autant éliminer les fissures. En revanche, la résorption partielle des fissures a été observée en incorporant un polyélectrolyte anionique (la gomme xanthane) non adsorbé en surface des nanoparticules de silice ou un polymère neutre (le polyéthylène glycol, PEG) ayant une forte affinité pour la silice<br>This thesis work is part of an industrial issue aiming to achieve micrometer-thick deposits of lithium battery electrode materials by electrophoretic deposition. Due to constraints related to the large-scale use of organic solvent suspensions of ceramic materials, the EPD (ElectroPhoretic Deposition) process considered in the context of this work involves colloidal suspensions of nanoparticles in an aqueous medium, as well as pulsed polarization to limit the harmful water electrolysis phenomenon in obtaining dense deposits.The objective of this study is to optimize the EPD process in terms of deposition yield and quality, using model suspensions of silica nanoparticles. Thus, the synthesis conditions of these particles obtained by the Stöber approach, were optimized to get geometric and physico-chemical characteristics (zeta potential, isoelectric point) very similar to the industrial materials of interest.The deposition kinetics by EPD were simulated through a first finite element model and compared to experimental data on both monodisperse silica nanoparticle suspensions and polydisperse suspensions of industrial electrode materials.A second electrochemical model allowed simulating the evolution of pH at the electrode surface in pulsed mode and providing a better understanding of the process. The hypothesis of an extended mechanism of the DLVO theory including a decrease in pH resulting from water oxidation was highlighted in the low-frequency range of the pulsed regime. Furthermore, it was shown that this acidification can be limited by decreasing the duty cycle, thus increasing the relaxation period of the potential in pulsed mode, and operating at high frequencies (f > 1000 Hz).Finally, particular attention was focused on the cracking of deposits that occurs during the drying stage. The use of polydisperse model suspensions or drying conditions at high relative humidity improved the quality of the deposits without eliminating the cracks. However, incorporating an anionic polyelectrolyte (xanthan gum) that is not adsorbed on the surface of silica nanoparticles or a neutral polymer (polyethylene glycol, PEG) having a high affinity for silica induced a partial decrease of the cracks
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Tuladhar, Kapil. "Lim-only domain proteins in developmental haematopoiesis." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:d6b73e89-7095-402f-9d9f-4d7837a4db00.
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The production of adult blood initiates from the haematopoietic stem cell (HSC). This clinically important cell has the capacity to maintain all blood lineages throughout the lifetime of an organism. HSCs emerge de novo from the haemogenic endothelium in the ventral wall of the embryonic dorsal aorta, from where they go on to seed adult sites of haematopoiesis. We have shown that Lmo4a is required for the emergence of HSCs in the zebrafish, and go on to demonstrate that Lmo4a regulates expression of the critical transcription factor, gata2a. Strikingly, both over- and under-expression of gata2a in the dorsal aorta severely diminishes HSC production. The LIM-only domain protein Lmo4 has previously been shown to interact with the known haematopoietic regulator, Ldb1. Together with our collaborators, we have identified novel binding partners of Lmo4 in mouse erythroleukaemic cells. Our functional analysis shows that many of these partners are also necessary for HSC emergence, thus revealing several new potential regulators of HSC formation. Given that these proteins were identified in an in vitro model of definitive erythropoiesis, it is remarkable that they also appear to act together in vivo at the level of HSC formation, and our data suggests that a transcriptional complex containing Lmo4 and these partners may directly repress gata2a. The related protein Lmo2 is also known to bind Ldb1. Together with Scl, Lmo2 is a master regulator of the haemangioblast programme. We have been utilising this activity, together with recent structural studies, to identify functionally important residues in the Lmo2 molecule. As a cell’s transcriptional programme drives both normal and pathological development, and misexpression of both Lmo2 and Lmo4 is involved in a variety of oncogenic states, the work presented in this thesis is likely to inform efforts to develop therapeutically relevant reagents.
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Mochizuki, Atsushi. "On the Casson-Walker invariant of 3-manifolds with genus one open book decompositions." Kyoto University, 2019. http://hdl.handle.net/2433/242583.
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尾野, 雄一. "急性T細胞性白血病におけるTAL1とLMOファミリーの協調的転写活性化機構の解析". 京都大学 (Kyoto University), 2000. http://hdl.handle.net/2433/181174.
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要旨pdfファイル:タイトル「急性T細胞性白血病におけるTAL1とLMOファミリーの強調的転写活性化機構の解析」<br>Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(理学)<br>乙第10366号<br>論理博第1382号<br>新制||理||1181(附属図書館)<br>UT51-2000-F432<br>(主査)教授 竹市 雅俊, 教授 井口 八郎, 教授 岡 穆宏<br>学位規則第4条第2項該当
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Cordoba, Arenas Andrea Carolina. "Aging Propagation Modeling and State-of-Health Assessment in Advanced Battery Systems." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385967836.
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Gonzalez, Ricardo. "Leo." Thesis, California State University, Long Beach, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10096082.
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<p> Leo is a collection of short stories linked by the character, Leo. The stories follow Leo through different times, settings, and episodes in his life. In this collection, in the quest to understand the meaning of the self and individual, Leo attempts to learn the difference between good and bad and life and death. The stories feature odd family members, troubled relationships, and self-destructive coping mechanisms. Written in different narrative styles, the collection attempts to create a marriage between content and form with special attention to language. My stories hope to explore questions about cultural identity, emotional stability, and loss of innocence. </p>
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Beyene, Dereje, and Befkadu Degefa. "Adaptive Antenna Arrays for Satellite Mobile Communication Systems." Thesis, Linnaeus University, School of Computer Science, Physics and Mathematics, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-191.
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<p>Adaptive antenna arrays have a great importance in reduction of the effect of interference and increase the capacity for the mobile satellite communication. Interference and multipath fading remain a main problem for reception of signals. These two problems obviously affect the overall capacity. Adaptive antenna arrays in the handheld mobile apparatus will be the solution for the above two problems.</p><p> </p><p>Satellite mobile communication is one of the growing fields in the communication area where terrestrial infrastructures are unable or ineffective to supply. Maritime, aeronautical and land mobile are some of the applications. During natural disasters where ground services are stopped, mobile satellite communications has great importance. Following the hurricane season, the Asian Tsunami and the devastating Haiti earthquake, mobile satellite communications had played a great role to fill the communication gaps. The satellites can be tracked automatically by adaptive antenna array when it moves in its orbital plane.</p><p> </p><p>In this thesis the methods that how the adaptive antenna array combats interferers is presented and simulated using MATLAB software. The performance of the adaptive antenna array is evaluated by simulating the directivity pattern of the antenna and Mean Square Error (MSE) graph for different scenario like Signal to Interference Noise ratio (SINR), number of iterations, antenna array elements and convergence factor (μ), assuming the signals are coming from different Direction of Arrival (DOA).</p><p> </p><p> </p>
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Brückner, Robert [Verfasser], Karl [Akademischer Betreuer] Leo, Karl [Akademischer Betreuer] Lao, and Thomas [Akademischer Betreuer] Riedl. "Coherence and Coupling of Cavity Photons and Tamm Plasmons in Metal-Organic Microcavities / Robert Brückner. Gutachter: Karl Lao ; Thomas Riedl. Betreuer: Karl Leo." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://d-nb.info/1068152850/34.
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Obermöller, Trixi [Verfasser]. "Evaluation von drei supraglottischen Atemwegshilfen im klinischen Alltag ( LMA Unique, Ambu LMA und Soft Seal LMA) / Trixi Obermöller." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2014. http://d-nb.info/1054165963/34.
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Jobrack, Stewart Evan. "Being Lao: An Ethnographic Study of a Lao-American Buddhist Community." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492756924204915.
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Sawangdee, Chansy Dalavong Yothin. "Determinants of low birth weight among Lao Loum infants in Lao PDR /." Abstract, 2004. http://mulinet3.li.mahidol.ac.th/thesis/2547/cd368/4638498.pdf.
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Liu, Yun. "Congestion management and LMP." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=12403.
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Peltier, Anatole-Roger. "Le roman classique lao." Paris 3, 1986. http://www.theses.fr/1986PA030062.
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Les romans classiques lao sont, pour la plupart, des versifications de contes epiques. Ils sont principalement destines a etre lus devant un auditoire, lors des veillees. Il en existe plus d'une centaine de titres sous forme de manuscrits et beaucoup de ces manuscrits, consistant en feuilles de latanier gravees en caracteres lao anciens, ont ete edites sous forme de brochures imprimees en caracteres lao modernes, depuis 1957, surtout par le comite litteraire, l'academie royale et la bibliotheque nationale lao. L'etude des sources montre que ces romans s'inspirent de la litterature indienne, de la litterature yuan, de la litterature du vieux fonds indochinois, de la litterature siamoise et du pannasajataka, un recueil de jataka apocryphes d'origine mone. Les romans purement lao et ayant un caractere original sont des romans historiques. Bien qu'appartenant a la litterature laique, ou domine d'ailleurs le merveilleux, les romans lao sont fortement impregnes par les enseignements bouddhiques et les themes developpes tournent autour du dharma et du karma. Il s'agit, en fait, d'un bouddhisme populaire qui ne cherche qu'a inculquer les preceptes de base a la grande masse des habitants. Depuis 1975, date de l'instauration de la republique democratique et populaire lao, les romans les plus connus et les plus apprecies font l'objet de recuperation de la part des nouvelles autorites pour illustrer leurs themes politiques, comme ils le furent jadis par les moines pour repandre l'enseignement bouddhique<br>The most of lao classic tales are the epic poems. They are principally intended to be read in front of the public, in the evenings. There are more than one hundred stories in palmleaves manuscript forms which are engraved with the old lao characters. Some of these manuscripts have been printed in modern lao characters since1957, especially by the literary committee, the royal academy and the lao national library. The study of these origin tales shows that they were inspired by the indian literature, the yuan literature, the old indochinese fund literary, the siamese literature and the pannasajataka, the collection of apocryphal jataka coming from the mon civilization. The lao classic purely tales which have the original characters, are the historic stories. Although these tales belonged to the laic literature in which "the marvellous" dominated, they are impregnated by the buddhist teaching and the developped topics turned around the dharma and the karma. It concerns, in fact, that the popular buddhism finds to inculcate the basic precepts for the large population. Since 1975, date of the lao people's democratic republic instauration, the most well know tales are recuperated by new government to illustrate the political topics, as the classic tales were widespread for the buddhist teaching by the monks in the past
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Matveeva, Daria. "Strategie firmy Leo Express." Master's thesis, Vysoká škola ekonomická v Praze, 2017. http://www.nusl.cz/ntk/nusl-358946.
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This Master thesis deals with the valuation of Leo Express, a. s. to the date January 1, 2016. As a valuation method was used the earnings valuation method based on discounted free cash flow to the firm and equity (FCFF). The thesis is split into two parts The methodical part defines the terminplogy and used indicators. The practical part is a detailed analysis of the market for transport of passenger rail services in the Czech Republic, Slovak Republic and Poland by used PEST analysis. The part of Master thesis is also financial analysis of the company. Process of valuation was implemented on the base of well-prepared financial plan and other value drivers. The evaluation itself has been accomplished using three-phase DCF method,which is consist of a prediction phase,second faze and a residual value phase.
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Peltier, Anatole-Roger. "Le Roman classique Lao." Paris : École française d'Extrême-Orient : diff. A. Maisonneuve, 1988. http://catalogue.bnf.fr/ark:/12148/cb35292925k.
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Arellano, Chevez Ada Alvina. "Leo, comprendo y aprendo." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2018. http://tesis.pucp.edu.pe/repositorio/handle/123456789/10593.
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Como una profesional involucrada con la formación educativa de la niñez y, en especial, con aquella perteneciente al centro poblado de Serrán donde ejerzo la docencia he creído por conveniente desarrollar esta investigación conocedora de la situación actual por la que atraviesan los educandos de la Institución Educativa N° 14663, en cuanto a la comprensión lectora se refiere. Al respecto, he desarrollado un Plan de Acción que basa su explicación en la problemática de la comprensión lectora entre los alumnos de la IE antes indicada denominado “LEO, COMPRENDO Y APRENDO”. Siendo, entonces el objetivo principal que busca mi investigación mejorar el nivel de comprensión lectora de los estudiantes de la I.E. N°14663 de Serrán, para lo cual tienen que asumir un compromiso social tanto los estudiantes, como los docentes, los padres de familia y, los directivos. He podido identificar una diversidad de causas, tales como: Pocas estrategias para la comprensión lectora por parte del docente; pocos hábitos de lectura en los alumnos; desconocimiento para elaborar material educativo que promueva la comprensión lectora por parte del docente; el docente no elabora el material educativo adecuado debido a que no está preparado para construir tales elementos, como por ejemplo, fichas de lectura. Desarrollaré este plan de acción basándome en las teorías de Treviño, Pedroza, Pérez, Ramírez y, Ramos en su experiencia exitosa denominada “Practicas docentes `para el desarrollo de la comprensión lectora en primaria” y también en la de Rita Castillo contenida en su experiencia del “Cuentito Viajero”. Espero que la puesta en marcha del plan de acción permita que los estudiantes de la I.E. N° 14663 enfrenten la comprensión en las competencias de comunicación y matemáticas como la resolución de problemas, obteniéndose mejores resultados en los indicadores de comprensión lectora y resolución de matemáticas.<br>Trabajo académico
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Croce, Filippo <1995>. "Leo Strauss: filosofo neoconservatore?" Master's Degree Thesis, Università Ca' Foscari Venezia, 2020. http://hdl.handle.net/10579/17005.
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Questo lavoro ha lo scopo di illustrare l’enigmatica presenza del filosofo Leo Strauss all’interno del movimento Neoconservatore, a cui è stato collegato svariate volte, soprattutto dai media giornalistici, ma anche da alcuni lavori accademici. Si è analizzato in primo luogo la posizione del filosofo, soffermandosi su alcuni dei suoi testi cardine. Si è anche preso in considerazione il legame tra Strauss e alcuni pensatori “problematici”, come Martin Heidegger e Carl Schmitt. Nel secondo capitolo si è cercato di chiarire la posizione di Strauss riguardo gli USA, e come da una serie di tesi apparentemente contradditorie egli sia riuscito ad approdare ad una visione positiva su di essi. Si è inoltre fornito un esempio, per il tramite di un testo di Thomas Pangle, di come gli allievi del Filosofo abbiano approfondito la posizione straussiana nei confronti dell’America, andando a ricercarne le origini. Il terzo capitolo ha approfondito invece la questione del legame tra Strauss e la Destra americana, come la sua posizione sia stata criticata e come essa sia stata traghettata da alcuni pensatori (Bloom e Fukuyama) fino al pensiero neoconservatore, non però senza una sostanziale modifica. Il capitolo finale si è occupato di trattare una breve storia del Neoconservatorismo, dalle sue origini fino alla Presidenza Bush, soffermandosi anche su colui che ne viene definito il padre fondatore, Irving Kristol.
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Hirschauer, Jürgen. "Leo Grewenig (1898-1991) - Leben und Werk mit einem kritischen Katalog sämtlicher Arbeiten /." [S.l. : s.n.], 1998. http://deposit.ddb.de/cgi-bin/dokserv?idn=963017780.
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Wagner, Tim [Verfasser], Karl [Akademischer Betreuer] Leo, Karl [Gutachter] Leo, and Thomas [Gutachter] Riedl. "Composite-Cavity Organic Microlasers / Tim Wagner ; Gutachter: Karl Leo, Thomas Riedl ; Betreuer: Karl Leo." Dresden : Technische Universität Dresden, 2019. http://d-nb.info/1226901565/34.
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Lam, Wing-lan. "Humour in Lao She's prose Lao She san wen de you mo te dian' /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40676572.
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Stumm, Andreas, and Norbert Pfurr. "Klassifikationen, Konkordanzen & GEO-LEO." Universitätsbibliothek Chemnitz, 2005. http://nbn-resolving.de/urn:nbn:de:swb:ch1-200500697.
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Dr. Adreas Stumm von der Universitätsbibliothek „Georgius Agricola“ der Technischen Universität Berbauakademie Freiberg (UB Freiberg) stellte GEO-LEO vor, definiert als die „Virtuelle Fachbibliothek für Geowissenschaften, Bergbau, Geographie und Thematische Karten“. GEO-LEO entstand – DFG-gefördert - aus der Zusammenarbeit der geo- und montanwissenschaftlichen Sondersammelgebietsbibliotheken UB Freiberg und der Niedersächsischen Staats- und Universitätsbibliothek Göttingen. Der Nutzer von www.geo-leo.de adressiert mit seiner Suchanfrage (sozusagen unwissentlich) über Z39.50 die OPACs in Freiberg, Göttingen und diejenigen der Partnerbibliotheken GFZ in Potsdam und der ETH-Bibliothek in Zürich. Darüberhinaus werden die Aufsätze in den Online Contents des Anbieters Swets OLC (SSG Geowissenschaften) gefunden sowie über HTTP die herkömmlichen Internet-Erträge aus Geo-Guide. Aufgewertet wurden die Retrievalerträge der beteiligten OPACs durch Konkordanzleistung in der Weise, daß klassifikatorische Verbindungen gelegt wurden zwischen Klassifikaten der UDC, DDC und BK sowie der sog. GOK (Göttinger Onlineklassifikation).
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Stumm, Andreas, and Norbert Pfurr. "Klassifikationen, Konkordanzen & GEO-LEO." Universitätsbibliothek Chemnitz, 2007. http://nbn-resolving.de/urn:nbn:de:swb:ch1-200701317.
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Das Original-Dokument wurde in das Format pdf umgewandelt.
Dr. Adreas Stumm von der Universitätsbibliothek „Georgius Agricola“ der Technischen Universität Berbauakademie Freiberg (UB Freiberg) stellte GEO-LEO vor, definiert als die „Virtuelle Fachbibliothek für Geowissenschaften, Bergbau, Geographie und Thematische Karten“. GEO-LEO entstand – DFG-gefördert - aus der Zusammenarbeit der geo- und montanwissenschaftlichen Sondersammelgebietsbibliotheken UB Freiberg und der Niedersächsischen Staats- und Universitätsbibliothek Göttingen. Der Nutzer von www.geo-leo.de adressiert mit seiner Suchanfrage (sozusagen unwissentlich) über Z39.50 die OPACs in Freiberg, Göttingen und diejenigen der Partnerbibliotheken GFZ in Potsdam und der ETH-Bibliothek in Zürich. Darüberhinaus werden die Aufsätze in den Online Contents des Anbieters Swets OLC (SSG Geowissenschaften) gefunden sowie über HTTP die herkömmlichen Internet-Erträge aus Geo-Guide. Aufgewertet wurden die Retrievalerträge der beteiligten OPACs durch Konkordanzleistung in der Weise, daß klassifikatorische Verbindungen gelegt wurden zwischen Klassifikaten der UDC, DDC und BK sowie der sog. GOK (Göttinger Onlineklassifikation).
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Almayali, Rafaa. "Improving Learning Results through LMS." Thesis, Uppsala universitet, Institutionen för informatik och media, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-226253.
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藍詠蘭 and Wing-lan Lam. "Humour in Lao She's prose." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40676572.
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Tiikkainen, M. (Matti). "LDO-jänniteregulaattori piirin sisäiseen tehonhallintaan." Master's thesis, University of Oulu, 2014. http://urn.fi/URN:NBN:fi:oulu-201401111002.
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In this master’s thesis, design topologies and challenges of low-power, integrated low-dropout regulators have been studied. Various topologies have been examined and compared. Low-dropout regulators are commonly used in multitude of applications, ranging from high-power systems to battery powered mobile devices. The advantages of low-dropout regulators include simplicity, low noise and low input-output voltage drop. The main challenge in designing modern low-dropout regulators is achieving a high current efficiency by reducing the quiescent current consumption of the system. In addition, the compensation of regulators is challenging when the load current varies on a high dynamic range. This thesis concentrates on designing an integrated low-dropout regulator with high dynamic range, good regulation performance and high current efficiency. Based on the topology study, the regulator was designed around a class AB error amplifier, the main advantage of which is the independency between the quiescent and output currents. High dynamic performance on large load currents was achieved by utilizing an adaptive biasing circuit for the amplifier. In addition, a switched feedback resistor network was designed in order to adjust the output voltage and improve the dynamic performance. The selected circuit topologies were used to design and simulate a fully integrated implementation and a regulator with an external capacitor in order to supply current for a digital load<br>Tässä diplomityössä on tutkittu matalatehoisten, integroitujen low-dropout -regulaattorien rakenteita sekä suunnitteluhaasteita. Työssä tutkittiin ja vertailtiin erilaisia toteutustopologioita. Low-dropout -regulaattoreita käytetään monenlaisissa sovelluksissa ulottuen korkeatehoisista järjestelmistä akkukäyttöisiin mobiililaitteisiin. Low-dropout -regulaattorien etuihin kuuluvat yksinkertaisuus, matala kohina sekä pieni tulon ja lähdön välinen jännite-ero. Modernien low-dropout regulaattorien pääasialliset suunnitteluhaasteet kohdistuvat korkean virtahyötysuhteen saavuttamiseen pienentämällä lepovirtaa. Lisäksi regulaattorien kompensointi on haasteellista kun lähtövirran vaihtelualue on laaja. Työssä on keskitytty suunnittelemaan integroitu regulaattori, jolla on laaja lähtövirran vaihtelualue, hyvä regulointikyky sekä korkea virtahyötysuhde. Topologiavertailun perusteella regulaattori suunniteltiin käyttäen AB-luokan virhevahvistinta, jonka hyöty on biasvirran ja lähtövirran riippumattomuus toisistaan. Korkea dynaaminen suorituskyky suurilla kuormavirroilla saavutettiin käyttämällä vahvistimen biasoinnissa adaptiivista biaspiiriä. Lisäksi työssä suunniteltiin kytketty vastusverkko lähtöjännitteen säätämiseksi sekä suorituskyvyn parantamiseksi. Valittuja toteutustopologioita käyttämällä suunniteltiin kokonaan integroitu regulaattori sekä erillinen toteutus ulkoisella lähtökondensaattorilla jotta regulaattori pystyisi ajamaan digitaalista kuormaa
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Huaman, Tello Lourdes. "Leo y comprendo textos narrativos." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2018. http://hdl.handle.net/20.500.12404/17243.
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El proyecto de innovación educativa se denomina “Leo y comprendo textos
narrativos”, surge con la finalidad de mejorar el desempeño de los estudiantes en la
capacidad de localizar información de diversos textos narrativos, el objetivo central
de este proyecto es lograr que los docentes apliquen adecuadas estrategias para la
comprensión literal de textos narrativos, la construcción del proyecto tiene dos partes:
Marco conceptual y el diseño del proyecto. Los conceptos que sustentan la
innovación son, los textos narrativos que nos permiten comprender, comunicar
nuevas ideas a los demás, la comprensión lectora al leer las personas reaccionan
frente al texto, imaginando e interpretando o construyendo una idea de su posible
significado, estrategias didácticas de comprensión lectora son procesos ejecutivos,
ligados a tareas muy concretas, y conceden a las estrategias propias el carácter de
capacidades cognitivas de orden más elevado, los niveles de comprensión:
comprensión literal que se encuentra explicita en el texto, comprensión inferencial
que se encuentra implícita en el texto, comprensión crítica asumir una posición frente
al texto. Para la construcción del proyecto de innovación educativa elaboré el FODA
teniendo en cuenta, las fortalezas, debilidades, oportunidades y las amenazas de mis
estudiantes, contando con este material elaboré el árbol de problemas, el árbol de
objetivos, la matriz de consistencia, el objetivo general, el objetivo central, la
estructura del perfil del proyecto de innovación educativa, el marco conceptual. Al
finalizar la implementación del proyecto se espera lograr elevar el nivel de
comprensión de textos y por ende obtener mejores resultados en las evaluaciones
censales en el área de comunicación, los resultados que este proyecto quiere
alcanzar son: docentes capacitados que aplican adecuadas estrategias para la
comprensión literal de textos narrativos.<br>Trabajo académico
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Rios, Flores Consuelo. "Cuanto más leo, más aprendo." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2018. http://hdl.handle.net/20.500.12404/15403.
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El proyecto de innovación educativa se denomina “Cuanto más leo, más
aprendo”; surge como una necesidad para mejorar el nivel de desempeño en la
capacidad para inferir e interpretar información de textos narrativos, en los niños y
niñas del segundo grado “A”, de la IE N° 2020 Maestro José Antonio Encinas ubicado
en el distrito de Comas. El objetivo central de este proyecto, es docentes aplican
estrategias adecuadas para desarrollar la capacidad para inferir e interpretar
información de textos narrativos. Los conceptos que sustentan la innovación son:
leer, comprender, estrategia y niveles de comprensión lectora, por lo que se revisa la
propuesta de algunos autores y especialistas en el tema como es el caso de Isabel
Solé y otros. Para la construcción del proyecto de innovación educativa, se ha
seguido un procedimiento metodológico, iniciado con el análisis de la matriz FODA,
árbol de problemas, árbol de objetivos, matriz de consistencia y se la fundamentación
teórica. Al finalizar la implementación del proyecto se espera lograr, docentes
capacitados en estrategias para inferir e interpretar información de textos narrativos,
docentes investigan sobre estrategias que permitan al estudiante desarrollar la
capacidad de inferir e interpretar información del texto y docentes que aplican
estrategias creativas que permiten inferir e interpretar información de textos
narrativos. Finalmente, se concluye que los docentes capacitados y que aplican
estrategias creativas; permite que niños y niñas se desarrollen como lectores,
autónomos, críticos y reflexivos, con la consiguiente inferencia e interpretación de
textos narrativos.<br>Trabajo académico
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Morante, Deza Sandra Mabel. "Leo, comprendo, resuelvo y aprendo." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2019. http://hdl.handle.net/20.500.12404/15289.
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Este proyecto de innovación educativa denominado “Leo, comprendo, resuelvo y
aprendo” nace frente a la necesidad de tratar de dar solución a un serio problema
presentado en los niños y niñas del segundo grado de primaria de la I.E. N° 145
Independencia Americana, en quienes se ha podido ver una marcada deficiencia en la
resolución de problemas matemáticos, ubicándolos específicamente en los problemas de
igualación: como producto de los resultados obtenidos en los exámenes ECE que son
aplicados por el Ministerio de Educación durante el año académico y cuyos resultados han
reflejado niveles de logro no esperados, ya que dentro de los aprendizajes esperados para
la institución y orientados por los porcentajes alcanzados el año anterior surge un
problema que desestabiliza el desempeño y capacidad de nuestros niños y niñas en
cuanto a esta competencia.
Ante este impase como institución nos hemos propuesto la ejecución de este
proyecto de innovación buscando que los docentes del segundo grado apliquen estrategias
metodológicas con nuestros niños y niñas que ayuden a promover habilidades, generando
interés y movilizando capacidades matemáticas para trabajar eficientemente el enfoque de
resolución de problemas.
Al investigar sobre cómo resolver problemas matemáticos se ha encontrado a
muchos investigadores, científicos matemáticos que han realizado una serie de estudios
tratando de encontrar la forma más fácil de enseñar a sus alumnos y son los que dan
sustento a este trabajo; entre ellos podemos citar a Polya (1945), Kilpatrick (1967), Santos
(2007), Schoenfeld (1985), (1992), Postman y Weingartner (1969), Lester y Kehle (2003),
Lesh y Kelly (2000), Cobo y Fortuny (2000), Puig (1996), todos ellos tienen muchos
puntos de coincidencia al afirmar que cuando los estudiantes tratan con tareas o
problemas que les son significativos, desencadenan ideas matemáticas fundamentales
teniendo disposición, poniendo en juego sus creencias y actitudes, así como sus
antecedentes y experiencias y que es el salón de clases el que debe promover actividades
y hábitos consistentes con la práctica real de la resolución de problemas.
Por lo tanto se espera que con la ejecución del presente proyecto los docentes
puedan planificar, programar y desarrollar unidades de aprendizaje que activen en
nuestros niños y niñas capacidades matemáticas para resolver problemas promoviendo su
participación activa y asegurándose de elevar su desempeño y formar seres competentes
y comprometidos con el proceso de enseñanza aprendizaje dentro del enfoque de
Resolución de Problemas, cumpliendo de esta manera con dar solución al problema que
se tiene a nivel institucional.<br>Trabajo académico
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Bulíková, Jana. "Financování mezinárodních akvizicí formou LBO." Master's thesis, Vysoká škola ekonomická v Praze, 2007. http://www.nusl.cz/ntk/nusl-1884.
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Práca sa zaoberá problematikou financovania akvizícií metódou LBO. Popisuje podstatu financovania akvizície úverovou pákou, rozoberá motívy pre zrealizovanie LBO ako aj prínosy a možné riziká vyplývajúce z LBO transakcie. Práca charakterizuje úrovne a druhy akvizičného dlhu (Prioritný dlh, Mezanínový dlh) a popisuje celkový proces štrukturovania LBO transakcie. Rozoberá prístup banky k akvizičnému financovaniu a pojednáva o základných technikách financovania LBO prostredníctvom banky. Práca zahrňuje praktické príklady LBO transakcií a obsahuje vývoj na trhu LBO a trendy financovania LBO.
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Durdil, Lukáš. "Aspekty financování akvizic formou LBO." Master's thesis, Vysoká škola ekonomická v Praze, 2008. http://www.nusl.cz/ntk/nusl-9063.
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This diploma thesis deals with the acquisition of companies by means of the Leveraged Buyout (LBO) method. This method differs in many respects from the standards M&A. This work examines the specific features of the given business transactions from the viewpoint of the target companies, procedures and entities involved in these transactions. As the key element of the LBO method is the debt financing of the acquisition, the work also deals with this aspect and evaluates the positions of the creditors from the viewpoint of the influence on the stability of the financial system. The thesis further analyses the question whether the LBO method has an effect leading to an increased effectiveness of processes in a company, or whether, conversely, the proceeds of acquisition investors are a consequence of a transfer of values from other entities. The text is based on available theoretical and empirical sources which are supplemented by the author's analyses.
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Lomberský, Jakub. "Využití LMS v podnikové praxi." Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-149989.
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The goal of my master's thesis is a description of the Moodle learning management system, and demonstration of its usability in human resources supporting the whole process of systematical approach in training and further development of employees. In order to confirm its applicability I describe the real system implementation. My master's thesis also includes supporting objectives to support the main objectives. The purpose of their use is to introduce the reader to the problematic of training and further development. Supporting objectives are: to introduce the issue of training and further development of employees in organizations, introduction of systematical approach to training of employees in organizations, introduction of methods and forms of education with a focus on e-learning and blended learning and introduction of learning management systems and learning content management systems.
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Souza, Francisco das Chagas de. "Algoritmos adaptativos LMS normalizados proporcionais." Florianópolis, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/96392.
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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.<br>Made available in DSpace on 2012-10-26T11:34:42Z (GMT). No. of bitstreams: 0Bitstream added on 2013-07-16T20:55:04Z : No. of bitstreams: 1
309939.pdf: 4352344 bytes, checksum: 0535613da00725ae9a3e9b7d04f2957c (MD5)<br>Neste trabalho, um novo algoritmo LMS normalizado proporcional (PNLMS) é proposto. Tal algoritmo usa fatores de ativação individuais para cada coeficiente do filtro adaptativo, em vez de um fator de ativação global como no algoritmo PNLMS padrão. Os fatores de ativação individuais do algoritmo proposto são atualizados recursivamente a partir dos correspondentes coeficientes do filtro adaptativo. Essa abordagem conduz a uma melhor distribuição da energia de adaptação entre os coeficientes do filtro. Dessa forma, para respostas ao impulso com elevada esparsidade, o algoritmo proposto, denominado algoritmo PNLMS com fatores de ativação individuais (IAF PNLMS), atinge maior velocidade de convergência do que os algoritmos PNLMS padrão e PNLMS melhorado (IPNLMS). Também, uma metodologia de modelagem estocástica dos algoritmos da classe PNLMS é apresentada. Usando essa metodologia, obtém-se um modelo estocástico que prediz satisfatoriamente o comportamento do algoritmo IAF PNLMS tanto na fase transitória quanto na estacionária. Através de simulações numéricas, a eficácia do modelo proposto é verificada. Adicionalmente, uma versão melhorada do algoritmo IAF PNLMS, denominada EIAF PNLMS, é proposta neste trabalho, a qual usa uma estratégia de redistribuição de ganhos durante o processo de aprendizagem, visando aumentar os ganhos atribuídos aos coeficientes inativos quando os ativos aproximam-se da convergência. Resultados de simulação mostram que tal estratégia de redistribuição melhora significativamente as características de convergência do algoritmo
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Mischok, Andreas Verfasser], Karl [Akademischer Betreuer] [Gutachter] [Leo, and Malte [Gutachter] Gather. "Controlling Light in Organic Microcavities / Andreas Mischok ; Gutachter: Karl Leo, Malte Gather ; Betreuer: Karl Leo." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://d-nb.info/1137830123/34.
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Rosenow, Thomas Verfasser], Karl [Akademischer Betreuer] [Leo, and Klaus [Akademischer Betreuer] Meerholz. "White Organic Light Emitting Diodes / Thomas Rosenow. Gutachter: Karl Leo ; Klaus Meerholz. Betreuer: Karl Leo." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://d-nb.info/1067188347/34.
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Mischok, Andreas [Verfasser], Karl [Akademischer Betreuer] [Gutachter] Leo, and Malte [Gutachter] Gather. "Controlling Light in Organic Microcavities / Andreas Mischok ; Gutachter: Karl Leo, Malte Gather ; Betreuer: Karl Leo." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-206972.
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Sanogo, Ashken N'Doh. "Analyse organisationnelle de deux hôpitaux réputés à succès en République Démocratique Populaire Lao (RDP Lao)." Master's thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/27556.
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Problématique : À l'instar de beaucoup de pays en développement, la qualité des services offerts dans les hôpitaux de la RDP Lao, surtout périphériques, est souvent critiquée. Il est dès lors intéressant d'examiner les cas "à succès", ceux dont on considère qu'ils devraient être des modèles pour le pays. Tel est le cas de 2 hôpitaux de la province de Vientiane, dont le développement a été soutenu par la Coopération luxembourgeoise. Méthodologie: Cette étude est une étude de cas multiples portant sur deux hôpitaux (Maria Teresa et Vang Vieng). Elle visait à étudier les facteurs organisationnels associés à la perception par les travailleurs en santé et les femmes enceintes ou en post-partum, de la performance des soins obstétricaux offerts dans ces hôpitaux. Des entrevues individuelles, basées sur des thématiques découlant du cadre conceptuel de l'étude ont été réalisées. Résultats : L'analyse des résultats montrent une grande satisfaction tant de la part des travailleurs des hôpitaux que des utilisatrices de services, avec les services offerts, même si certains services attendus ne sont pas systématiquement offerts. Les principaux facteurs associés à la fonctionnalité perçue des deux hôpitaux sont liés à deux aspects : un investissement dans les ressources humaines et un investissement dans l'accessibilité de population-cible aux services obstétricaux. L'investissement en ressources humaines a porté sur des stratégies visant l'expertise de tous, cliniciens et non cliniciens, la valorisation du travail du personnel et la création d'une ambiance d'équipe plaisante. L'investissement dans l'accessibilité a porté sur les barrières géographiques et économiques, ainsi que sur la diffusion d'information dans la communauté sur l'importance des soins périnatals. Conclusion : Un investissement dans les ressources humaines et l'accessibilité aux services permet aux hôpitaux régionaux de la RDP Lao de devenir fonctionnels et performants. Mots clés : soins obstétricaux, coopération luxembourgeoise, qualité des services de santé, ressources humaines, RDP Lao.<br>Problematic: Like many developing countries, the quality of services provided in Lao hospitals, especially in remote regions, is often criticized. It is therefore interesting to examine "successful" cases hospitals that are considered by many as models for the rest country. Such is the case of two hospitals in the province of Vientiane, whose evolution was supported by Luxembourg Cooperation. Methodology: This study is a multiple case study took place in two hospitals (Maria Teresa and Vang Vieng). It aimed to study organizational factors associated with the perception by health workers and pregnant or postpartum, of the performance of obstetric care. Individual interviews, based on themes derived from the conceptual framework of the study were performed. Results: Analyses of the results show a great satisfaction with the services offered by both, hospital workers and users, even if some expected services are not routinely offered. The main factors associated with the perceived functionality of the two hospitals are related to two aspects: an investment in human resources and an investment in the accessibility of the target population to obstetric services. The investment in human resources focused on strategies aiming the improvement of the expertise detained by all, clinicians and non-clinicians, the recognition of the work done by the staff and the creation of a pleasant atmosphere for team work. Investment in accessibility focused on geographical and economic barriers, as well as on providing information on the importance of perinatal care to the community. Conclusion: An investment in human resources and in the accessibility to services allows regional hospitals of the Lao PDR to become functional and efficient. Key words: Obstetric care, Luxembourg cooperation, quality of care, human resources, RDP Lao.
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Kauffmann, Clemens. "Strauss und Rawls : das philosophische Dilemma der Politik /." Berlin : Duncker & Humblot, 2000. http://www.gbv.de/dms/sub-hamburg/317565842.pdf.
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Jahnel, Matthias Stephan Verfasser], Karl [Akademischer Betreuer] [Leo, Karl [Gutachter] Leo, and Stefan [Gutachter] Mannsfeld. "Organische Photosensoren mit spektraler Anpassung / Matthias Stephan Jahnel ; Gutachter: Karl Leo, Stefan Mannsfeld ; Betreuer: Karl Leo." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://d-nb.info/1151127132/34.
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Selzer, Franz Verfasser], Karl [Akademischer Betreuer] [Leo, and Frank [Akademischer Betreuer] Nüesch. "Transparent Electrodes for Organic Solar Cells / Franz Selzer. Betreuer: Karl Leo. Gutachter: Karl Leo ; Frank Nüesch." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://d-nb.info/1095395467/34.
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Timmreck, Ronny Verfasser], Karl [Akademischer Betreuer] [Leo, and Christoph [Akademischer Betreuer] Brabec. "Characterization of tandem organic solar cells / Ronny Timmreck. Betreuer: Karl Leo. Gutachter: Karl Leo ; Christoph Brabec." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://d-nb.info/1078205132/34.
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Tumenta, PN, JS Kok, Rijssel JC van, et al. "Threat of rapid extermination of the lion (Panthera leo leo) in Waza National Park, Northern Cameroon." Blackwell Publishing Ltd, 2009. http://encore.tut.ac.za/iii/cpro/DigitalItemViewPage.external?sp=1001447.
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Abstract
Lion populations in West and Central Africa are small and
fragmented. In areas where park management is weak,
threats will likely facilitate the extinction of the lion.
Wildlife management requires knowledge of the population
estimate. The population of lions in Waza National
Park (Waza NP) was assessed by individual identification
of members in the population. The population was assessed
to comprise of 14–21 adult individual lions. The age
structure was skewed towards adults; cubs comprised 22%
of all lions identified while the sex ratio was 1 : 3. Two out
of four collared lions were lost to illegal, retaliatory killings
within 1 year; and probably two more males and one more
female were also killed during this period. The lion population
appears to have declined during the last 5 years
with six lions dying per year, which is at a much higher
rate than observed in the previous decades. Human-livestock
pressure has increased tremendously in this period,
resulting to frequent human-lion conflicts. To ensure the
survival of the lion in Waza NP and in the entire region,
management needs to intensify efforts to mitigate the
pressure from humans and their livestock.
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Timmreck, Ronny [Verfasser], Karl [Akademischer Betreuer] Leo, and Christoph [Akademischer Betreuer] Brabec. "Characterization of tandem organic solar cells / Ronny Timmreck. Betreuer: Karl Leo. Gutachter: Karl Leo ; Christoph Brabec." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://d-nb.info/1078205132/34.
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Jahnel, Matthias Stephan [Verfasser], Karl [Akademischer Betreuer] Leo, Karl [Gutachter] Leo, and Stefan [Gutachter] Mannsfeld. "Organische Photosensoren mit spektraler Anpassung / Matthias Stephan Jahnel ; Gutachter: Karl Leo, Stefan Mannsfeld ; Betreuer: Karl Leo." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://d-nb.info/1151127132/34.
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Strandberg, Carl-Johan. "Leveraged Buyouts : An LBO Valuation Model." Thesis, Karlstad University, Faculty of Economic Sciences, Communication and IT, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-5776.
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<p>During the eighties a new type of financial transaction started to emerge on an increasing basis. It was the so called “leveraged buyout” also known as the LBO. In the US private equity firms made it to the headlines in financial media from engaging in leveraged buyouts with small equity investments and large amounts of borrowed capital, their targets where large solid multinational corporations. Much has happened since the eighties. Back then leveraged buyouts where often associated with terms such as “Slash and Burn” or “Buy, Flip and Strip” often meaning hostile takeovers and huge layoffs. Today private equity firms focus more on active ownership, fast decisions without the bureaucracy of the stock market and long term value creation in order to profit from their buyouts.</p><p>As private equity firms today invest tremendous amounts of capital through their private equity funds. Leveraged buyouts have become one of the major areas within investment banking. Even though the LBO is a common transaction it is often hard to find models used for valuation of such a deal. Private equity funds and investment banks all have their own valuation models but these are regarded as strictly confidential and seldom revealed to the public. Therefore the creation and publication of an LBO valuation model should be of great interest for everyone aiming at a future career within private equity, corporate finance or investment banking.</p><p>This thesis derives a complete LBO valuation model including a framework for finding a suitable LBO target. The LBO valuation model is created in cooperation with the debt capital markets department at one of the leading investment banks in the Nordic region. The framework is based on a qualitative study conducted on seven of the most distinguished private equity firms active in Sweden. In order to show how the LBO valuation model and the framework works, both are applied on the retail company Björn Borg listed on NASDAQ OMX. To verify the accuracy of the framework, calculated return from the model is analyzed and compared to the indications given by the framework.</p>