Dissertations / Theses on the topic 'Liver fat'
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Migid-Hamzza, Jeffery A. "Fat Metabolism in Smooth Dogfish." University of Akron / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=akron1132414091.
Full textLam, Shi. "The significance of hepatic stellate cell activation in small-for-size fatty liver graft injury /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B3829686X.
Full textGrundström, Tobias. "Automated Measurements of Liver Fat Using Machine Learning." Thesis, Linköpings universitet, Datorseende, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-151286.
Full textBanerjee, Rajarshi. "The effects of excess body weight on the heart and liver." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:652e90cd-1f11-4fb6-8a4b-4ce649f72ee5.
Full textLewandowski, Paul, and mikewood@deakin edu au. "Liver fat metabolism, obesity and diabetes in Psammomys Obesus." Deakin University. School of Health Sciences, 1999. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20050825.111432.
Full textGubík, Ladislav. "Automatic quantification of fat in liver using Computer Vision /." Leeds : University of Leeds, School of Computer Studies, 2008. http://www.comp.leeds.ac.uk/fyproj/reports/0708/Gubik.pdf.
Full textCrabtree, Christopher David. "Effects of Controlled Hypocaloric Ketogenic and Low-Fat Diets on Liver Fat in Overweight/Obese Adults." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1586780375128754.
Full textShoebotham, Karen. "The relationship between liver fat content and unenhanced computed tomography." [New Haven, Conn. : s.n.], 2008. http://ymtdl.med.yale.edu/theses/available/etd-12092008-161843/.
Full textLam, Shi, and 林璽. "The significance of hepatic stellate cell activation in small-for-sizefatty liver graft injury." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45012933.
Full textLee, Sang Jun. "CEACAM1 : a common regulator of fat metabolism and cell proliferation." Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1218146004.
Full text"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 74-82, 116-124, 146-192.
Orabi, Danny Ahmad. "The Effects of High Fat Diet on Liver Disease and Hepatocellular Carcinoma." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1619778405639812.
Full textEvans, Alison. "The splanchnic circulation and chronic heart failure." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324047.
Full textPisto, P. (Pauliina). "Fat accumulation in liver and muscle:association with adipokines and risk of cardiovascular events." Doctoral thesis, Oulun yliopisto, 2013. http://urn.fi/urn:isbn:9789526201351.
Full textTiivistelmä Lihavuus on kasvava ongelma länsimaissa. Lihavuudella on todettu olevan yhteyttä lukuisiin kroonisiin sairauksiin, kuten diabetekseen ja sydän- ja verisuonitautiin. Ei-alkoholiperäinen rasvamaksa aiheutuu rasvan kertymisestä maksaan. Tilan on todettu liittyvän läheisesti vaikeisiin aineenvaihdunnan häiriöihin. Ei-alkoholiperäinen rasvamaksa vaihtelee vakavuusasteeltaan poikkeavasta rasvan kertymisestä tulehdukseen, joka voi edelleen johtaa kirroosiin ja maksan toiminnan pettämiseen. Adiponektiini on pääasiassa rasvakudoksen erittämä hormoni, jolla on tulehdusta hillitseviä, ateroskleroosilta suojaavia ja insuliinia herkistäviä ominaisuuksia. Rasvakudoksen tulehdustila myötävaikuttaa alentuneeseen adiponektiinipitoisuuteen, joka voi johtaa vaikeutuneisiin aineenvaihdunnan häiriöihin. Adiponektiinin epäillään olevan välittäjäaine lihavuuden ja rasvamaksan ja lihaksensisäisen rasvan välillä. Rasvamaksan ja kardiovaskulaarisairauksien välillä saattaa olla yhteys. Sydän- ja verisuonisairaudet aiheuttavat lähes puolet kuolemista Suomessa. Perinteisiä kardiovaskulaaritaudin riskitekijöitä ovat ikä, sukupuoli, tupakointi, korkea LDL-kolesteroli, korkea verenpaine ja diabetes. Tutkimuksemme tavoitteena oli selvittää maksan ja lihaksen rasvan kertymiseen myötävaikuttavia tekijöitä sekä rasvamaksan vaikutusta riskiin sairastua sydän- ja verisuonisairauksiin. Tutkimuksessa havaittiin, että lihavuuteen liittyvistä hormoneista adiponektiini oli vahvin itsenäinen myötävaikuttaja rasvamaksan kehittymisessä. Plasman alentunut adiponektiinipitoisuus yhdistyi kasvaneeseen lihassolun kokoon riippumatta henkilöiden rasvakudoksen määrästä. Seurantatutkimuksen mukaan vaikeasti rasvoittunut maksa lisäsi riskiä sairastua kardiovaskulaaritautiin, ennusti yleistä kuolemanriskiä ja kuolemaa kardiovaskulaaritautiin. Insuliiniherkkyydellä näytti olevan merkittävä rooli sydän- ja verisuonitautitapahtumissa. Tutkimus osoittaa, että adiponektiinillä saattaa olla keskeinen rooli rasvan kertymisessä maksaan ja lihakseen. Adiponektiini voi olla keskeinen tutkimuskohde kehiteltäessä hoitomuotoja ja ehkäisymenetelmiä rasvakudoksen ulkopuolisen rasvan kertymiseen. Rasvamaksan rooli sairaalahoitoon tai kuolemaan johtavissa ateroskleroottisissa tapahtumissa on ilmeinen
Liang, Wentao. "Myostatin promotes liver fat accumulation through activation of the mTOR-SREBP-1c pathway." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12479.
Full textMyostatin is a cytokine primarily expressed in skeletal muscle and heart muscle and acts as a negative regulator for muscle development. Inhibition of myostatin by genetic and pharmacological approaches improves metabolic health, which has been generally considered as secondary to the hypermuscularity and insulin hyper-sensitivity. Although the receptor for myostatin is ubiquitously expressed, whether and how myostatin interacts with other metabolically important cell types remain largely unknown. In this work, we provide multiple lines of evidence that myostatin directly interacts with hepatocytes. Furthermore, we show for the first time that myostatin enhances insulin signaling in both cultured hepatocytes and in mouse liver. Mice injected with adena-associated virus encoding myostatin propeptide, an endogenous myostatin inhibitor, were partially protected from diet-induced liver fat accumulation and reduced lipogenic gene expression. Consistent with the in vivo findings, increased lipid accumulation was found in cells treated with myostatin peptide or transfected with myostatin construct. Myostatin promotes the lipogenic effect of insulin by enhancing nuclear translocation of SREBP-1c, the master lipogenic transcription factor and increases expression of its downstream target genes. This effect was found to be associated with myostatin-related mTOR activation. Blocking mTOR activation by rapamycin prevents myostatinassociated increase of nuclear SREBP-1 c and its downstream lipogenic enzymes. In summary, this work identified liver as a direct target of myostatin, providing the first evidence that myostatin has opposite impacts on insulin signaling in muscle cells and hepatocytes. Our data also provided a novel mechanism for the long-term metabolic protection afforded by anti-myostatin treatments demonstrated in this work as well as elsewhere.
Abrahams, Celeste H. "The modulation of effect of fatty acids on the lipid in colon epithelial mucosa in Vivo /." Online access, 2009. http://etd.uwc.ac.za/usrfiles/modules/etd/docs/etd_gen8Srv25Nme4_3963_1275516655.pdf.
Full textIggman, David. "Dietary Fatty Acids and Cardiometabolic Risk : Influence on Lipoproteins, Insulin Resistance and Liver Fat." Doctoral thesis, Uppsala universitet, Klinisk nutrition och metabolism, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-252066.
Full textThoma, Christian. "Exercise, glucose control and liver fat : providing the evidence for translation into clinical care." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2340.
Full textCain, James. "Characterizing the role of dietary fat in the development and progression of liver dysfunction." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/dissertations/903.
Full textYang, Yan. "CEACAM1 : a molecular link between fat metabolism and insulin clearance." Connect to full-text via OhioLINK ETD Center, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1115060085.
Full textIn partial fulfillment of the requirements for the degree of Doctor of Philosophy in Medical Sciences. Major advisor: Sonia Najjar. Includes abstract. Document formatted into pages: v, 167 p. Bibliography: pages 117-165.
Toyama, Yoshiro. "Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity." Kyoto University, 2015. http://hdl.handle.net/2433/202801.
Full textOwen, Carl. "The role of adipocyte and liver protein tyrosine phosphatase 1B (PTP1B) in glucose homeostasis and insulin sensitivity." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203411.
Full textKohan, Alison Bloom. "Mechanism by which dietary polyunsaturated fat regulates lipogenic gene expression." Morgantown, W. Va. : [West Virginia University Libraries], 2009. http://hdl.handle.net/10450/10605.
Full textTitle from document title page. Document formatted into pages; contains viii, 141 p. : ill. (some col.). Includes abstract. Includes bibliographical references.
Wu, Nan. "Regulation of hepatic inflammatory response and lipid metabolism in metabolic disease." The American Physiological Society, 2009. http://hdl.handle.net/1993/23352.
Full textRosqvist, Fredrik. "Dietary Fatty Acids, Body Composition and Ectopic Fat : Results from Overfeeding Studies in Humans." Doctoral thesis, Uppsala universitet, Klinisk nutrition och metabolism, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280949.
Full textZhang, Linda S. "Apolipoprotein A-V: A Novel Liver-gut Signal Protein that Regulates the Production of Chylomicrons." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439305376.
Full textAl-Share, Qusai Y. "Reduction of hepatic CEACAM1 levels : an early mechanism of insulin resistance induced by high-fat diet." Connect to full text in OhioLINK ETD Center, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1201787222.
Full text"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 120-176.
Penke, Melanie, Per S. Larsen, Susanne Schuster, Morten Dall, Benjamin A. H. Jensen, Theresa Gorski, Andrej Meusel, et al. "Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet." Elsevier, 2015. https://ul.qucosa.de/id/qucosa%3A38585.
Full textAbel, Stefan. "Fatty acids as cancer preventive tools in the dietary modulation of altered lipid profiles associated with hepatocarcinogenesis." Thesis, University of the Western Cape, 2005. http://etd.uwc.ac.za/index.php?module=etd&.
Full textNeves, Christian André Fernandes. "Methylglyoxal-induced glycation changes liver lipid content in high-fat diet-fed rats, causing glucose and lipid systemic dysmetabolism." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14597.
Full textFatty liver disease is simultaneously a cause and a consequence of type 2 diabetes. Hepatic lipid metabolism is altered in obese patients, causing insulin resistance. More, inhibition of insulin signaling may also affect hepatic lipid metabolism, causing a feedback that may lead to hepatic steatosis, common in such patients. In this work, we intended to assess the role of glycation (methylglyoxal-induced) in the hepatic lipid metabolism of high-fat diet-fed rats, using lipidomic approaches and magnetic resonance imaging, which identify hepatic lipid species, including phospholipids (PL), triglycerids (TG), diacylglycerols (DAG) and fatty acids (FA). Wistar rats were maintained during 4 months with methylglyoxal (MG) supplementation (100mg/Kg/day) (MG group), a high-fat diet rich in TG (HFD group) or both (HFDMG group) and compared with controls feeding a standard diet (n=6/ group). Lipidomic approaches, namely liquid chromatography - mass spectrometry (LC-MS) and gas chromatography (GC) were used to determine liver composition in PL, TG and FA. Non-invasive 1H nuclear magnetic resonance (NMR) spectroscopy (9 Tesla) of liver tissues in vivo was used to determine lipid species, such as TG and DAG. The total and phosphorylated levels of the mediators of the insulin receptor pathway and lipid oxidation were determined by western blotting. High-fat diet-fed (HFD) rats showed increased body weight in relation to controls, but this effect was partially inhibited by MG supplementation (HFDMG group). Moreover, HFDMG group showed increased plasma free fatty acid levels, hyperinsulinemia, insulin resistance and glucose intolerance. In liver, lipidomic techniques and 1H NMR showed increased fat mass in the liver of HFD and HFDMG rats. HFD rats, but not HFDMG, showed increased total levels of the 18:1 fatty acid (common in high-fat diets). Despite no differences were observed for HFD group, HFDMG rats showed decreased fraction of unsaturated lipids and increased fraction of saturated lipids. This difference was obtained due to a decrease in monounsaturated FA. Regarding lipid esterification, HFDMG group showed lower percentage of esterified glycerol carbons, suggesting an increased concentration of DAG in relation to TG. In accordance, this group showed higher fatty acids/glycerol ratio, suggesting increased liver non-esterified fatty acid levels. Western Blotting analyses showed decreased activation of insulin pathway, especially HFDMG group, as well as decreased activation of the insulin receptor in HFDMG group. Data suggest that glycation changes lipid metabolism in a context of hyperlipidemia, possibly contributing to hepatic lipotoxicity and to accelerate progression of insulin resistance and fatty liver disease.
O fígado gordo é simultaneamente uma causa e consequência da diabetes mellitus tipo 2. O metabolismo lipidico-hepático (MLH) encontra-se alterado em obesos, causando insulino-resistência. A diminuição da sinalização da via da insulina pode igualmente afetar o MLH, estimulando o desenvolvimento de esteatose hepática, comum nos doentes. Neste trabalho, pretende-se analisar o papel da glicação (induzida por metilglioxal) no MLH em ratos com dieta gorda, através de técnicas de lipidómica e ressonância magnética, para identificar as espécies lipídicas hepáticas, tais como fosfolípidos (FL), triglicéridos (TG), diacilgliceróis (DAG) e ácidos gordos (AG). O modelo animal usado foi o rato Wistar, mantido nos últimos 4 meses, antes de completar 1 ano de idade, com metilglioxal (100mg/Kg/dia) (grupo MG), com dieta gorda rica em TG (grupo HFD) ou com ambas (grupo HFDMG) e comparados com os controlos com dieta normal (n=12/grupo). As técnicas de lipidómica usadas foram cromatografia líquida com espetrometria de massa e cromatografia gasosa para determinar a composição hepática de PL, TG e AG. Usou-se também espectroscopia (9 Tesla), não invasiva, de ressonância magnética nuclear 1H (NMR) nos ratos vivos para determinar os TG e DAG hepáticos. Os mediadores proteicos totais e fosforilados da via da insulina e da oxidação lipídica no fígado também foram analisados por western blot. Os ratos, com dieta gorda (HFD), aumentaram o peso corporal, mas o efeito foi parcialmente inibido pelo metilglioxal (HFDMG). Além disso, o grupo HFDMG apresenta um aumento dos ácidos gordos livres no plasma, hiperinsulinemia, insulino-resistência e intolerância à glicose. No fígado, as técnicas de lipidómica e NMR mostraram um aumento da massa gorda no fígado nos grupos HFD e HFDMG, mas apenas no grupo HFD se verifica o aumento do AG 18:1 (comum na dieta). Apesar de não haver diferença significativa no grupo HFD, o grupo HFDMG apresenta uma diminuição dos AG insaturados e aumento dos saturados; isto deve-se à diminuição dos monoinsaturados neste grupo. Quanto à esterificação dos glicerolípidos, o grupo HFDMG apresenta uma menor percentagem da total esterificação dos gliceróis, sugerindo o aumento dos DAG, em relação aos TG. Também, este grupo apresenta um ratio AG/glicerol aumentado, ou seja, com aumento de AG não esterificados. A análise por western blot mostrou uma diminuição da via do receptor da insulina especialmente no grupo HFDMG. Em suma, estes resultados sugerem que a glicação causa alterações do metabolismo lipidico-hepático num contexto de hiperlipidemia, contribuindo possivelmente para a lipotoxicidade hepática, progressão acelerada de insulino-resistência e patologia do fígado gordo.
Saffaf, Jasem. "Klinische Bedeutung der Leberverfettung bei Kühen." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-170356.
Full textProblem: The fatty liver is considered to be one of the most important metabolic disorders in early lactation in dairy cows and is a reason for poor health, including reproductive disorders. Objective: Therefore the following questions in this study were studied: a) importance of the clinical and laboratory findings at the initial examination of sick cows, especially the liver fat, b) relationships between liver fat content and various laboratory parameters, c) the relationship between the liver fat content, diseases and the treatment success, d) prognostic significance of liver fat content and clinical-chemical and hematological blood parameters. Material and Methods: For 312 bovine patients, provided chronological to the MTK Leipzig, were examined according to clinical and laboratory investigations including liver biopsy and evaluated the findings of the initial examination. Results: In 312 cattle, divided in 18 disease groups, 196 left and 40 right-sided abomasal displacements (LMV), 11 abomasal ulcers, 182 ketoses, 96 mastitis, endometritis 178, 7 Retentio sec., puerperal sepsis, 7 and 6 multi organ failure, 42 Indigestion, 31 enteritis, 46 peritonitis, 30 downer cows and 18 pneumonia diagnosed. The cows were grouped in four liver fat classes as follows: ≤6% = 14.7%; 6 to ≤15% = 37.5%; 15 to ≤30% = 31.1% and> 30% = 16.7%. The cure rate was in the first three classes of liver fat 80.4%, 83.8% and 86.6% respectively. A relationship between the cure rate and the liver fat content was not recognizable to ≤30%. In the liver fat class> 30% cure rate dropped to 61.5%; at> 40% it worsened <50%. This corresponded to the behavior of various laboratory parameters. Only when liver fat content> 30%, particularly at> 45%, were partly regardless of the outcome of the disease, the BHB, bilirubin and glucose concentrations as well as AST, CK, LDH, GGT and GLDH activities were significantly higher and the inorg. Phosphate (Pi) and cholesterol concentrations low. The liver fat content correlated most closely (p <0.001), the parameters BHB (0.620) and FFS (0.615), LDH (0.579), bilirubin (0.367), AST (0.359), cholesterol (-0.278), lactate (-0.253), hemoglobin (0.214), CK (0.207), leukocytes (-0.202) and internal body temperature (0.210). The significance of these relationships is relative. Sensitivity and specificity were Pi (<1.25 mmol / l)> 0.7, to cholesterol (<1.5 mmol / l) and albumin (<30 g / l)> 0.6, and for BHB, urea, and total protein> 0.5. High specificity> 0.8 for low sensitivity had K (<3.0 mmol / l) and segment neutrophilic granulocytes (<4.6 g / l), a high sensitivity> 0.8, but low specificity bilirubin (> 5 , 3 mol / l) AST (> 80 U / l) and CK (> 200 U / l). With regard to disease outcome and thus the prognostic value of the area under the curve (AUC) for K (0.37), bilirubin (0.62), AST (0.61) and liver fat (0.60) were weakly secured. The liver-specific enzymes GGT and GLDH correlated only weakly with 0.126 (p <0.05) and 0.192 (p <0.001) with the liver fat. This do not challenges their diagnostic significance, but it makes clear that in the studied diseases no greater liver damage occurred. Whereas the correlation, sensitivity and specificity calculations as well as some ROC/AUC analysis informative parameter LDH, AST, CK, C, Pi, bilirubin (> 20 μmol/l) and leukocytes indicate inflammatory processes. The increased liver fat in every group glucose concentrations, esp. at liver fat > 30% and ex. letalis, thus organize at least partially as a result of insulin resistance. Cows with DA had usually. additional disorders: 58% ketoses, 57% endometritis, 6.4% Retention sec, puerperal septicemia and multi-organ failure, 30.8% mastitis, 14.7% of peritonitis, enteritis 9.9%, 9.6% recumbency, 5.8% pneumonia and 3.5% ulceration of the abomasum. Furthermore, came to 13.5% before indigestion. The cure rate of left and right DA, mastitis, endometritis and enteritis were between 89% to 70% and for indigestion and acute peritonitis 70-60%. In chronic peritonitis, pneumonia, Retention sec., Puerperal septicemia, recumbency, abomasum ulcers and multiple organ failure they fell from 50% to 0%. The liver fat content varied with DA, mastitis, endometritis, chronic peritonitis and indigestion between 6% and 19%. He rose with a worse clinical outcome in Retentio sec., Pneumonia, acute peritonitis puerperal septicemia, DA ulcers and enteritis up to 30% and was at Festliegern, high-grade endometritis and multiorgan failure until about 40%. Conclusions: Liver fat to ≤30% is clinically insignificant. The trend towards higher liver fat and poorer cure rate underscores the importance of strong inflammatory diseases reason for the disease development and therapeutic success. The copper sulphate test according to Herdt can be recommended for use in practice
Baker, Callum John. "Effects of Exercise Training on Liver Fat and Circulating Immune Markers in People who are Obese or Overweight with Normal or Dysglycaemia." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29173.
Full textCosta, Yuri Ajala da. "A proposal for full-range fat fraction estimation using magnitude MR imaging." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/18/18152/tde-01102018-083519/.
Full textOs métodos atuais para estimação de gordura hepática por densidade de prótons (PDFF) utilizando imagem de magnitude de ressonância magnética (RM) enfrentam o desafio de estimar corretamente quando a gordura é a molécula dominante, ou seja, PDFF é maior que 50%. Assim, a acurácia desses métodos é limitada a meio intervalo de operação. Apresentamos aqui um método baseado em redes neurais para regressão capaz de estimar pelo intervalo completo de frações de gordura. Construímos uma rede neural baseada nos ângulos e distâncias entre os dados do sinal discreto da imagem de RM (ADALIFE), usando esses atributos associados a diferentes valores de PDFF, com sinais simulados considerando diferentes relações sinal-ruído (SNR). Resultados foram comparados para verificar a repetibilidade e concordância através de análise de regressão, Bland- Altman e curvas de característica de erro de regressão (REC). Resultados para o método Multi-interferência (estado-da-arte) foram similares aos relatados in vivo pela literatura, ressaltando a relevância das simulações. ADALIFE foi capaz de estimar corretamente frações de gordura até 100%, quebrando o paradigma para intervalo completo de operação utilizando apenas processamento posterior à aquisição de imagens ou sinais. Considerando meio intervalo, nosso método superou o estado-da-arte em termos de repetibilidade e concordância, com limites mais estreitos e menor erro esperado em qualquer SNR.
Kloock, Lisa [Verfasser], Michael [Gutachter] Roden, and Ulrich [Gutachter] Flögel. "The correlation of liver fat content and insulin resistance with skeletal muscle energy metabolism / Lisa Kloock ; Gutachter: Michael Roden, Ulrich Flögel." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2017. http://d-nb.info/1136717900/34.
Full textKloock, Lisa Verfasser], Michael [Gutachter] [Roden, and Ulrich [Gutachter] Flögel. "The correlation of liver fat content and insulin resistance with skeletal muscle energy metabolism / Lisa Kloock ; Gutachter: Michael Roden, Ulrich Flögel." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2017. http://d-nb.info/1136717900/34.
Full textElkatry, Haiam Omar Mohamed Verfasser], and Dietrich [Akademischer Betreuer] [Knorr. "Nonalcoholic fatty liver disease: Regulation of glucose and fat metabolism in the liver by Carbohydrate Response Element Binding Protein (ChREBP) and impact of dietary influence / Haiam Omar Mohamed Elkatry. Betreuer: Dietrich Knorr." Berlin : Universitätsbibliothek der Technischen Universität Berlin, 2011. http://d-nb.info/1016533543/34.
Full textDillard, Kayla A. "Inclusion of Olive or Coconut Oil in a High-Fructose High-Fat Diet Increases Liver Injury in a Pig Model of Pediatric NAFLD." DigitalCommons@CalPoly, 2021. https://digitalcommons.calpoly.edu/theses/2308.
Full textCepero, Donates Yuneivy. "Pathogenic role of IL-15 in non-alcoholic fatty liver disease." Mémoire, Université de Sherbrooke, 2014. http://hdl.handle.net/11143/5871.
Full textBerglund, Johan. "Separation of Water and Fat Signal in Magnetic Resonance Imaging : Advances in Methods Based on Chemical Shift." Doctoral thesis, Uppsala universitet, Enheten för radiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158111.
Full textBellenzani, Marcela Palomo Pieroni 1984. "Expressão de enzimas envolvidas na produção de triacilglicerol em tecidos adiposo e hepático isolados de ratos normo e hiperlipidêmicos." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314094.
Full textDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: A pandemia da obesidade é evidente no início do século XXI. O fator desencadeante mais relevante é a alimentação hipercalórica associada ao sedentarismo. Modelos de estudo em ratos para investigar as etapas que precedem o desenvolvimento desta doença são fundamentais para propor terapias de prevenção. No modelo de indução da dislipidemia pela dieta por quatro semanas, os ratos apresentam hipercolesterolemia, hipertrigliceridemia e hiperinsulinemia e com seis semanas de administração da dieta observa-se um aumento no peso dos panículos adiposos da região epididimal e peri-renal e sem alteração no depósito da região mesentérica. Assim sendo, objetivamos, nesta tese, analisar as vias metabólicas envolvidas no processo de metabolização da glicose e triacilgliceróis nos tecidos adiposo branco e hepático em ratos hiperlipidêmicos e para tal estudamos as vias lipogênica, lipolítica e neoglicogênica, pela quantificação da expressão gênica das enzimas chaves envolvidas nestes processos. A dislipidemia foi induzida pelo oferecimento de dieta hiperlipídica (grupo dieta, D) ao longo de quatro semanas a ratos jovens e a instalação do quadro foi verificada pelas análises plasmáticas ao final do tratamento e após jejum de 16h. Amostras de tecidos hepático e adiposo foram coletadas para análise histológica e quantificação da expressão gênica sendo estas analisadas por qRT-PCR. Observou-se que ratos que ingerem dieta hiperlipídica (+129+10,13 g) ganham peso de forma semelhante aos ratos controle (C: +148+8,8 g) mesmo ingerindo quantidade significativamente menor de dieta (C: 20,8+0,62 g vs D: 14,87+0,66 g). As análises histológicas ilustram aumento no teor de depósitos de lipídeos no tecido hepático. A expressão gênica no tecido hepático de ratos dieta foi aumentada significativamente para as enzimas lipoproteína lipase, piruvato desidrogenase quinase 4 e fosfofrutoquinase 1 e diminuição significativa na expressão de glicose 6-fosfatase sem alteração na quantificação da expressão de acetil-CoA carboxilase alpha, gliceroquinase, piruvato desidrogenase fosfatase 2. Em relação ao tecido adiposo observamos que a expressão das enzimas acetil-CoA carboxilase e piruvato desidrogenase fosfatase 2 não foi significativamente alterada em nenhum dos depósitos adiposos. A lipase hormônio-sensível não apresentou alterações no tecido adiposo epididimal, porém teve sua expressão significativamente aumentada nos tecidos mesentérico e peri-renal. A expressão da lipoproteína lipase por sua vez, não se alterou no panículo adiposo epididimal nem no panículo adiposo mesentérico estando diminuída no panículo adiposo peri-renal. E por fim, a piruvato desidrogenase quinase 4 também não apresentou alterações nos depósitos epididimal e mesentérico porém no peri-renal sua expressão encontrou-se aumentada. Estes resultados, em conjunto, indicam que a dieta administrada por 4 semanas, mesmo não apresentando todas as alterações observadas com 6 semanas, pode ser útil para os estudos iniciais do quadro de dislipidemia que antecedem as disfunções metabólicas
Abstract: The pandemic of obesity is evident in the twenty-first century. The most important and triggering factor is the high-calorie diet associated with physical inactivity. Study models in rats to investigate the steps that precede the development of this disease are essential to propose preventive therapies. In the model of induction of dyslipidemia by diet for four weeks, the mice exhibit hypercholesterolemia, hypertriglyceridemia, and hyperinsulinemia and there is an increase in weight of the panniculus region of epididymal and peri-renal depot and no change in the mesenteric region. Therefore, we aimed to analyze the metabolic pathways involved in the metabolism of glucose and triglycerides in white adipose tissue, and liver in hyperlipidemic rats and to study the ways that lipogenic, lipolytic and glyconeogenic for the quantification of gene expression of key enzymes involved in these processes. Dyslipidemia was induced by offering high-fat diet (diet group, D) over four weeks to young rats and onset of condition was verified by analysis at the end of the plasma treatment and after fasting for 16 hours. Samples of liver and adipose tissue were collected for histological analysis and quantification of gene expression and these were analyzed by qRT-PCR. It was observed that mice eat high-fat diet (+129 +10.13 g) gain weight similarly to control rats (C: +8.8 +148 g) even eating significantly less diet (C: 20.8 +0.62 g vs D: 14.87 +0.66 g). Histological analysis illustrate the content of lipid deposits in liver tissue. Gene expression in liver tissue of rats diet was significantly increased for the enzymes lipoprotein lipase, pyruvate dehydrogenase kinase 4 and 1 and Phosphofructokinase significant decrease in the expression of glucose 6-phosphatase no change in the quantification of the expression of acetyl-CoA carboxylase alpha, Gliceroquinase, pyruvate dehydrogenase phosphatase 2. In relation to the adipose tissue we observed that the expression of the enzyme acetyl-CoA carboxylase and pyruvate dehydrogenase phosphatase 2 was not significantly altered in any of the fatty deposits. The hormone-sensitive lipase showed no changes in epididymal adipose tissue but its expression was significantly increased in mesenteric tissue and peri-renal. Lipoprotein lipase, in turn, did not change in the mesenteric or epididymal being reduced in the peri-renal. And finally, the pyruvate dehydrogenase kinase 4 also showed no changes in epididymal and mesenteric but the peri-renal expression is increased. These results, together, indicate that the diet for 4 weeks, even not showing all changes observed within 6 weeks, can be useful for the initial studies of hyperlipidemia that precede the metabolic dysfunctions
Mestrado
Fisiologia
Mestre em Biologia Funcional e Molecular
Patton, Ashley. "Characterization of the Very Early Development of High Fat Diet-induced Non-alcoholic Fatty Liver Disease (NAFLD) and Efficacy of Novel Therapeutics for its Treatment." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1521811677550828.
Full textCattelam, Jonatas. "Caraterísticas pós-abate de bovinos terminados com substitutos ao milho em dietas de alto grão." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4375.
Full textThe objective of this study was to evaluate the characteristics of non-integrant parts of steers and heifers, feedlot fed with high-grain diets. Were used forty-five cattle were used in two categories, with 21 heifers with initial age of 32 months and 24 steers with initial age of 20 months, from the crossing between Charolais and Nellore. The animals were assigned to treatments as according energy source in the diet, being these: rice; white oat or corn, being seven heifers and eight bulls for each diet. The animals were confined until, by estimate, hot carcass weight of 220 kg. A complety randomized experimental design was completely randomized in 3 x 2 factorial arrangement (three food treatments and two categories). Slaughter weights were higher for cattle fed with white oat (449.3 kg) or corn (430.4 kg) compared to animals that receiving rice (401.8 kg), with higher carcass yields for animals than received corn. For the relationship between the empty body weight and slaughter weight of cattle also was no difference between the diets used and the major relationship was observed for animals that received corn (88.3%) compared to animals fed with rice (84.9%) or oat (84.1%). The exception of heart fat, in different forms of expression, and abomasal fat, expressed in relation to the empty body weight, for the remaining fat deposits, animals fed rice showed lower values. Regarding of animal category, the steers showed greater development of internal organs in different expression forms and legs and total of peripheral components, expression in relation to the empty body weight, while heifers showed higher weight for omasum and higher deposition in total fat. Weights and yields of commercial cuts sidecut and sawcut were higher for cattle fed with white oat or corn. For the forequarter weight and arm circumference, animals that received corn were higher than the animals that received rice, with intermediate behavior for cattle fed with white oat. Animals that received rice showed tenderness (5.15 points) and palatability (5.46 points) lower compared those were fed white oat (5.73 and 6.40 points, respectively) or corn (6.04 and 6.45 points, in the same order). According as the animal categories, steers showed higher percentage of forequarter (38.00 against 37.4%), while heifers showed greater carcass length (126.0 against 123.1 cm). The use of high-grain diets based on corn or white oat in finishing cattle results in a higher development of internal organs and the digestive tract, produce carcasses with higher weight and adequate fat deposition and with higher yields of commercial cuts, while feeding with rice produce lean meats, however reduces the carcass weight, with higher chilling loss and less tenderness meat. The production of heifers or steers feedlot finished ensures similar organleptic meat products.
O presente estudo teve por objetivo avaliar as características pós-abate de novilhos e novilhas, terminados em confinamento alimentados com dietas de alto grão. Utilizaram-se 45 bovinos de duas categorias, sendo 21 novilhas com idade inicial de 32 meses e 24 novilhos com idade inicial de 20 meses, oriundos do cruzamento entre as raças Charolês e Nelore. Os animais foram distribuídos nos tratamentos conforme a fonte energética utilizada na dieta, sendo essas: arroz; aveia branca ou milho, sendo utilizados sete novilhas e oito novilhos para cada dieta alimentar. Os animais permaneceram confinados até atingir, por estimativa, peso de carcaça quente de 220 kg. O delineamento experimental foi o inteiramente casualizado, com arranjo fatorial 3 x 2 (três tratamentos alimentares e duas categorias de bovinos). Os pesos de abate foram superiores para os bovinos alimentados com aveia branca (449,3 kg) ou milho (430,4 kg) em relação aos animais que receberam arroz (401,8 kg), com maiores rendimentos de carcaça para os animais que receberam milho. Para a relação entre os pesos de corpo vazio e de abate dos bovinos também ocorreu diferença entre as dietas alimentares utilizadas sendo que a maior relação foi observada para os animais que receberam milho (88,3%) comparada aos animais alimentados com arroz (84,9%) ou aveia branca (84,1%). A exceção das gordura de coração, nas diferentes formas de expressa, e da gordura abomasal expressa em relação ao peso de corpo vazio, para os demais depósitos de tecido adiposo, os animais alimentados com arroz apresentaram menores valores. Com relação a categoria animal, os novilhos apresentaram maior desenvolvimento dos órgãos internos nas distintas formas de expressão, e das patas e total de componentes periféricos expressos em relação ao peso de corpo vazio, enquanto as novilhas apresentaram maior peso de omaso e maior deposição no total de gorduras. Os pesos e rendimentos dos cortes comerciais costilhar e serrote foram superiores para os bovinos que receberam aveia branca ou milho. Para o peso de dianteiro e perímetro de braço, animais que receberam milho foram superiores aos animais que receberam arroz, com comportamento intermediário para os bovinos que receberam aveia branca. Animais que receberam arroz apresentaram maciez (5,15 pontos) e palatabilidade (5,46 pontos) inferiores em relação aqueles que foram alimentados com aveia branca (5,73 e 6,40 pontos, respectivamente) ou milho (6,04 e 6,45 pontos, citados na mesma ordem). Quanto as categorias animais avaliadas, novilhos apresentaram maior rendimento de dianteiro (38,00 contra 37,4%) ao passo que novilhas demonstraram maior comprimento de carcaça (126,0 contra 123,1 cm). A utilização de dietas de alto grão a base de milho ou aveia branca na terminação de bovinos acarreta em maior desenvolvimento de órgãos internos e do trato digestório, produz carcaças mais pesadas, com adequada deposição de gordura e com melhor rendimento dos cortes principais da carcaça enquanto a alimentação com arroz em dietas de alto grão produz carnes mais magras, porém reduz o peso de carcaça, com maior perda ao resfriamento e carne de menor maciez. A produção de novilhas ou novilhos confinados assegura produtos cárneos de qualidades organolépticas similares.
Scanlon, Jessica Patricia. "High fat diet has sexually dimorphic effects on body composition, adiposity and glucose homeostasis in Poly(A)-binding protein 4 (Pabp4) knockout mice." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28893.
Full textThe finding that HFD revealed metabolic differences in the Pabp4-/- mice lead to the question of whether Pabp4-/- mice have issues adapting to other situations which require modulation of energy storage and glucose homeostasis. One such event is pregnancy, when maternal regulation of insulin resistance is tightly modulated throughout gestation. We therefore characterised the maternal Pabp4-/- environment in late pregnancy (E18.5), when insulin sensitivity decreases to 40-60% lower than pre-pregnancy which results reduced maternal glucose uptake, freeing the glucose up for the rapidly developing foetus. Pregnant Pabp4-/- mice had elevated plasma insulin concentration post fasting (63.7% increase), however glucose homeostasis was wildtype-like, both in terms of plasma glucose and insulin concentrations, throughout a GTT. However, plasma glucose and insulin concentrations in E18.5 Pabp4-/- foetuses were significantly decreased (9% and 44.3% respectively). Pabp4-/- foetuses also had reduced foetal and placental weight/length parameters. This establishes that the differences in weight observed at birth were present by late gestation and secondly, that the reductions in both foetal glucose and insulin concentrations which may contribute to or underlie the reduced growth. It also suggests that the differences seen in adulthood on HFD may be a consequence of metabolic differences present during pregnancy. Taken together, these data support the hypothesis that PABP4 plays a key role in the regulation of mRNAs which are important in growth, post-natal survival and metabolic adaption to high fat diet.
Ko, Wei-Huei, and 柯蘊慧. "The correlation between body fat, visceral fat and nonalcoholic fatty liver disease." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/13572316414529343756.
Full text臺北醫學大學
公共衛生學系暨研究所
104
Objective: The aim of this study is to investigate the correlation between body fat, visceral fat and presence of nonalcoholic fatty liver disease(NAFLD). Design: It is a cross-sectional study. Subjects: We collected data from physical examination subjects at Renai Branch of Taipei City Hospital from October 2013 to September 2015. The enrolled criteria required participants be 20 years or older. All subjects those with liver disease(hepatitis C virus antibody or hepatitis B surface antigen)or cirrhosis or malignant disease or biliary disease or use of antihypertensive or antidiabetic agents were excluded. Methods: Demographic data, biochemical data, body fat, visceral fat, fatty liver were collected by chart review. Body fat and visceral fat assessed by InBody 720 (Biospace, Seoul, Korea). Fatty liver was diagnosed by abdominal ultrasound. SPSS software version 21.0 was used to perform statistical analyses. A p value less than .05 was considered as statistic significance. Results: A total of 2,759 subjects were collected this study. The result of the analysis revealed that in terms of prevalence of NAFLD males exhibited a higher incidence than females. Those factors such as waist circumference, body mass index, body fat, visceral fat and metabolic syndrome were correlation with NAFLD. Multiple logistic regression was used in further analysis, showing that increased waist circumference, body mass index, body fat, visceral fat and metabolic syndrome were significant correlated factors for the present of fatty liver. Receiver operating characteristic suggested that visceral fat cut off point was 70.5 cm²(Youden''s index=0.4352). Conclusion: Visceral fat was a strong predictor of NAFLD.
Ribeiro, Mário J. P. "Fat quantification in liver using chemical shift imaging." Master's thesis, 2013. http://hdl.handle.net/10316/25143.
Full textHsin-YingLin and 林欣盈. "Effects of galactose on fat metabolism in mice liver." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/6t8mqs.
Full textTRAN, VAN-BIEN, and 陳文邊. "Application of Dixon method to study the correlation between liver fat content and types of liver disease." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/95456670675831987570.
Full text元培醫事科技大學
醫學影像暨放射技術系碩士班
104
Generally, human liver fat content is about 5-10%. When the liver is disturbed, fat content changes. There are many fat content inspection techniques, including biopsies, ultrasound (US), computed tomography (CT) and magnetic resonance imaging (MRI). Among these techniques, MRI is a non-invasive and no-radiation choice that possesses high sensitivity and specificity characteristics, though fairly costly. In this retrospective study, we collected water-only and fat-only images of 260 subjects (20-90 years), each of whom had already undergone the Dixon method measurement of their abdomens with a GE 1.5T MRI scanner, from January 2013 to July 2015. On each liver image, three circled regions of interest (ROI) with same volume were chosen to make sure of the homogeneity of these ROIs. The averaged fat-to-water ratios were then calculated for fat content of the liver in each subject. Concurrently, the types of liver disease in these subjects were classified into several groups. Finally, SPSS 20.0 statistical software was used for analysis. Our results showed significant differences in liver fat content among the age groups (p<0.05). Fat content in the 41- 60 age group (15%) is higher than the other two groups (20-40 at 10-11%; 61-90 at 12-14%). In addition, the fat content of the fatty liver group was 33%, and of the general liver disease, non-fatty liver group was 10-15%. The Pearson correlation analyses about with and without fatty liver in both male and female showed moderate to high correlations (p<0.001) regardless of malignant or benign disease. From this study and previous analyses in our group, we found the commercial Dixon method is likely not good enough for fat content quantification. For routine use in clinical studies in the future, it may need further optimization to avoid respiratory artifacts and signal phase problems
Hoe, Teck-Loong, and 胡德龍. "Lignosus rhinocerus attenuated high fat diet induced non-alcoholic fatty liver." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/09348138734810047733.
Full textChiu, Jian-Jia, and 邱健佳. "Assessment of Liver Fat With T2 Correction Using Magnetic Resonance Spectroscopic Image." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/50264668570634093508.
Full text國立臺灣科技大學
電子工程系
100
Early detection of non-alcoholic fatty liver disease (NAFLD) can prevent further complications such as steatohepatitis, fibrosis and cirrhosis. Currently quantification of liver fat content relies on liver biopsy which is highly invasive method is still the gold standard for the evaluation of hepatic steatosis, but invasive method had a lot of disadvantages. Noninvasive study will become important. For noninvasive, magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) are the good methods in lipid content test. There had a lot of outstanding research in MRS, But there focused in single voxel spectroscopy (SVS). In previous study, we used a fast magnetic resonance spectroscopic imaging (MRSI) techniques, acquisition sequence is proton echo-planar spectroscopic imaging (PEPSI) to measure lipid fat content. PEPSI is able to detect spatial distribution, and this is a fast acquisition sequence. In this thesis, we further investigated the influence of T2 relaxation effects. PEPSI scans with different TE were repeated 8 times to observe the reproducibility of T2 correction. Our results showed that the measured fat content is highly reproducible and the liver lipid T2 range is wide, so T2-correction is necessary in fat content quantified.
Liao, Chung-Chia, and 廖重佳. "Effects of Phenolic Acid on Body Fat, Fatty Liver and Bladder Cancer." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/64001795466210134686.
Full text中山醫學大學
生化暨生物科技研究所
104
Caffeic acid (CA) can inhibit toxin-induced liver injury. In this study, CA is assessed for its lipid lowering potential when oleic acid is used to induce non-alcoholic fatty liver disease in human HepG2 cells. The results showed that both the triglyceride and cholesterol content are decreased in the HepG2 cells by using the enzymatic colorimetric method. CA enhances the phosphorylation of AMP-activated protein kinase (AMPK) and its primary downstream target enzyme, acetyl-CoA carboxylase. CA down-regulates the lipogenesis gene expression of sterol regulatory element-binding protein-1 and its target genes through AMPK activation. C57BL/6 mice were fed a normal diet or a HFD (20% fat) with or without caffeic acid for 6 weeks. The supplementation of caffeic acid significantly lowered body weight, visceral fat mass, plasma GOT and GPT levels, FAS activity, and free fatty acid compared to the HFD group. Caffeic acid also lowered triglyceride and cholesterol concentrations in plasma and liver. Gallic acid (GA) has been shown to inhibit carcinogenesis in animal models and various cancer cell lines. The TSGH-8301 bladder cancer cell line was treated with different concentrations of gallic acid. It showed that GA inhibited TSGH-8301 bladder cancer cell proliferation via the PI3K/Akt and MAPK/ERK pathway. Our results showed that GA decreased Skp2 protein level and attenuated Skp2-p27 association. It is suggested that gallic acid acts upstream of the proteasome to control p27 levels and ultimately inhibits G2/M phase transition. Our study showed that GA suppressed bladder cancer cell invasion and migration through RhoB/p-AKT/p-IkB/NF-kB/MMP-2 signaling pathway. GA also increased ER alpha expression, which prevented bladder cancer in animal study. GA decreased FAS protein level in our study. It is possible that gallic acid inhibited TSGH-8301 bladder cancer cell growth, invasion and migration through inhibition of fatty acid synthase.
Long, Michelle. "Association between alcohol use behavior and liver fat in the Framingham Heart Study." Thesis, 2019. https://hdl.handle.net/2144/36033.
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