Dissertations / Theses on the topic 'Liver cells'
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Wu, Yue. "Generating Beta-cells from liver cells." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420423.
Full textTirnitz-Parker, Janina Elke Eleonore. "Primary culture and immortal cell lines as in vitro models to evaluate the role of TWEAK signalling in hepatic oval cells /." Connect to this title, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0039.
Full textHarrison, Sean. "Liver cell types derived from pluripotent stem cells." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/liver-cell-types-derived-from-pluripotent-stem-cells(7f39c3ec-facd-4c06-ab9a-7c171313eb05).html.
Full textLam, Shuk-pik. "Differentiation of mesenchymal stem cells (MSCs) into hepatocytes in acute liver injury." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085647.
Full textWarren, Alessandra. "Hepatic sinusoidal cells in liver immunology and ageing." Thesis, The University of Sydney, 2005. https://hdl.handle.net/2123/27902.
Full textBird, Thomas Graham. "Liver regeneration by hepatic progenitor cells." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5634.
Full textCheluvappa, Rajkumar. "Pathophysiology of Liver Sinusoidal Endothelial Cells." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/2802.
Full textCheluvappa, Rajkumar. "Pathophysiology of Liver Sinusoidal Endothelial Cells." University of Sydney, 2008. http://hdl.handle.net/2123/2802.
Full textOwing to its strategic position in the liver sinusoid, pathologic and morphologic alterations of the Liver Sinusoidal Endothelial Cell (LSEC) have far-reaching repercussions for the whole liver and systemic metabolism. LSECs are perforated with fenestrations, which are pores that facilitate the transfer of lipoproteins and macromolecules between blood and hepatocytes. Loss of LSEC porosity is termed defenestration, which can result from loss of fenestrations and/ or decreases in fenestration diameter. Gram negative bacterial endotoxin (Lipopolysaccharide, LPS) has marked effects on LSEC morphology, including induction LSEC defenestration. Sepsis is associated with hyperlipidemia, and proposed mechanisms include inhibition of tissue lipoprotein lipase and increased triglyceride production by the liver. The LSEC has an increasingly recognized role in hyperlipidemia. Conditions associated with reduced numbers of fenestrations such as ageing and bacterial infections are associated with impaired lipoprotein and chylomicron remnant uptake by the liver and consequent hyperlipidemia. Given the role of the LSEC in liver allograft rejection and hyperlipidemia, changes in the LSEC induced by LPS may have significant clinical implications. In this thesis, the following major hypotheses are explored: 1. The Pseudomonas aeruginosa toxin pyocyanin induces defenestration of the LSEC both in vitro and in vivo 2. The effects of pyocyanin on the LSEC are mediated by oxidative stress 3. Defenestration induced by old age and poloxamer 407 causes intrahepatocytic hypoxia and upregulation of hypoxia-related responses 4. Defenestration of the LSEC seen in old age can be exacerbated by diabetes mellitus and prevented or ameliorated by caloric restriction commencing early in life
Ma, Kwai-yee Stephanie. "Identification and characterization of tumorigenic liver cancer stem/progenitor cells." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557534.
Full textPoli, G. "Biochemical studies on CC14̲-induced liver injury using isolated rat liver cells." Thesis, Brunel University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379250.
Full textMa, Kwai-yee Stephanie, and 馬桂宜. "Identification and characterization of tumorigenic liver cancer stem/progenitor cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557534.
Full textpublished_or_final_version
abstract
Pathology
Doctoral
Doctor of Philosophy
Lam, Shuk-pik, and 林淑碧. "Differentiation of mesenchymal stem cells (MSCs) into hepatocytes in acute liver injury." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085647.
Full textChan, Kwok-kin, and 陳國堅. "In vivo study on cell cycle and checkpoint regulation during mouse liver development." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4559000X.
Full textKung, Janet Wui Cheung. "Investigating the liver progenitor cell niche in the developing human liver." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25953.
Full textAmofah, Eunice. "Bone marrow stem cells in liver disease." Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497234.
Full textLee, Matthew L., and Jonathan M. Peterson. "Ethanol Disrupts Metabolic Signaling in Liver Cells." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/69.
Full textViebahn, Cornelia Sabine. "Interaction between the immune system and liver progenitor cells." University of Western Australia. Biochemistry and Molecular Biology Discipline Group, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0055.
Full textEndo, Kosuke. "Pretransplant replacement of donor liver grafts with recipient Kupffer cells attenuates liver graft rejection in rats." Kyoto University, 2015. http://hdl.handle.net/2433/199205.
Full textCowie, David. "Differential induction of organic anion transporting polypeptides in rat liver." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted: no access until April 24, 2020, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25707.
Full textAnilkumar, Thapasimuthu Vijayamma. "The pathobiology of hepatic stem cells (oval cells)." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244072.
Full textAkingbasote, J. A. "The potential role of liver sinusoidal endothelial cells in drug-induced liver injury." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3005113/.
Full textLam, Shi. "The significance of hepatic stellate cell activation in small-for-size fatty liver graft injury /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B3829686X.
Full textGow, Adam George. "Production of canine hepatocyte-like cells from stem cell sources." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10057.
Full textKita, Sadahiko. "The protective effect of transplanted liver cells into the mesentery on the rescue of acute liver failure after massive hepatectomy." Kyoto University, 2016. http://hdl.handle.net/2433/216179.
Full textKyoto University (京都大学)
0048
新制・課程博士
博士(医学)
甲第19925号
医博第4145号
新制||医||1017(附属図書館)
33011
京都大学大学院医学研究科医学専攻
(主査)教授 長船 健二, 教授 伊達 洋至, 教授 坂井 義治
学位規則第4条第1項該当
Aravinthan, Aloysious Dominic. "Hepatocyte senescence in chronic liver disease." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708050.
Full textKöhn, Julia. "Characterisation of liver progenitor cells and their microenvironment during chronic liver disease and hepatocarcinogenesis." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/48824.
Full textAoi, Takashi. "Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells." Kyoto University, 2008. http://hdl.handle.net/2433/124215.
Full textDong, Xin Min. "HCV-Core over-expressed specifically in liver cells." Thesis, University of Ottawa (Canada), 2007. http://hdl.handle.net/10393/27834.
Full textDemirkiran, Ahmet. "Dynamics of regulatory T cells in liver transplantation." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10694.
Full textNobes, Catherine Diane. "The control of respiration of isolated liver cells." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316770.
Full textPandolfi, Vittoria. "Microencapsulation of hepatic cells for extracorporeal liver supply." Thesis, Compiègne, 2016. http://www.theses.fr/2016COMP2262/document.
Full textLiver shortage makes transplantation inapplicable to all acute liver failure patients. Bioartificial Iiver (BAL) devices represent a temporary solution for these patients which are thereby bridged tilt Iiver transplantation or regeneration BAL treatment offers blood purification and substitution of metabolic functions through the activity of hepatocytes (HEPs), which are integrated in the device within acclimating containers, so-called bioreactors. Primary human hepatocytes are the ideal cell type to use in BAL, but they are scarcely available and difficult to maintain in vitro. Co-culture of HEPs with supporting cells has been proposed as the most promising strategy for preserving HEP behaviors in in vitro conditions. In fact, assisting cells types hold their ability to influence functional responses of the HEPs by providing them with cues of the native organ.This PhD work proposed a novel approach of co-culture for the functional sustain and preservation of the HEPs in the environment of the fluidized bed bioreactor (designed in our Iaboratory). Definition of this model took inspiration from the cellular organization in the organ; therefore, it employed three major sinusoidal non-parenchymal cell populations (liver sinusoidal, Kupffer, and hepatic stellate cells) which, together with HEPs, were cultured with three-dimensional arrangement (spheroids) and according to specific proportions. The resulting model was characterized in terms of functional benefits for the HEPs, and then applied in the microenvironment of alginate beads, which provide cells with immunological and mechanical protection in the fluidized bed bioreactor. This spheroidal multi-cultured model revealed its potentiality in sustaining in vitro HEP behaviors over time. Although much remains to be refined, this model may represent an interesting approach for the progress of BAL
CROCE, STEFANIA. "Mesenchymal stromal cells on bioscaffold for liver bioengineering." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1329186.
Full text呂可欣 and Ho-yan Lui. "Effects of lipoic acid on oxidant-induced cytotoxicity in HepG2 cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969768.
Full textLui, Ho-yan. "Effects of lipoic acid on oxidant-induced cytotoxicity in HepG2 cells." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2203240X.
Full textO'Neill, Kathy. "Reprogramming hepatocytes into duct-like cells." Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528369.
Full textLing, Changchun, and 凌长春. "The role of graft injury in mobilization of endothelial progenitor cells, myeloid derived suppressor cells and regulatory T cells afterlive transplantation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47849769.
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Surgery
Doctoral
Doctor of Philosophy
Ge, Xupeng. "Mechanisms of liver allograft rejections /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-330-2/.
Full textChandrasekaran, Prakash Gerber David A. "Encapsulation of hepatic progenitor cells for liver tissue engineering." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,963.
Full textTitle from electronic title page (viewed Dec. 18, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biomedical Engineering." Discipline: Biomedical Engineering; Department/School: Medicine.
Al, Echrish Noori H. Jasim. "Liver development and the role of mesenchymal stem cells." Thesis, University of Nottingham, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.580160.
Full textLu, Wei-Yu. "Defining the liver repopulating capacities of hepatic progenitor cells." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17875.
Full textTostões, Rui Manuel Lucas Gameiro Domingues. "Process engineering of liver cells for drug testing applications." Doctoral thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/7612.
Full textThe primary culture of human hepatocytes is a requirement in drug development tests. This application is currently hampered by two problems: the limited proliferation of the hepatocytes and the rapid loss of liver-specific phenotype of these cells, when cultured in vitro. This thesis aimed at minimizing this latter issue by cultivating hepatocytes, as spheroids, in fully controlled bioreactors. The state of the art of the primary cultures of hepatocytes is reviewed in Chapter 1, after a brief introduction to the liver physiology the drug development process. The improvement of the bioreactor cultures of hepatocyte spheroids was initially done using freshly isolated rat hepatocytes; the effects of alginate microencapsulation, perfusion culture and their synergy on the maintenance of the hepatocyte spheroids liver-specific phenotype were assessed in Chapters 2 and 3; it was concluded that the perfusion culture and alginateencapsulation had a positive synergic effect on such hepatic phenotype. The perfusion bioreactor developed in Chapter 3 was used in Chapter 4 for the extended culture of freshly isolated human hepatocytes, as spheroids, from three different donors. These cultures responded to repeated dose drug treatments as expected from mature and differentiated hepatocytes, in up to 4 weeks culture time. In Chapter 5, human embryonic stem cell-derived hepatic progenitors were cultured as spheroids and further differentiated into hepatocyte-like cells; the differential expression of hepatic genes between this spheroid population and a monolayer differentiated hepatocyte-like cell population showed a more efficient differentiation under spheroid culture. The bioengineering improvements of this thesis, as well as the future work, were discussed in Chapter 6. This thesis has led to the establishment and validation of primary cultures of hepatocyte spheroids, in perfusion bioreactors, which can be used for long-term, repeated dose tests in drug development.
Azuma, Hisaya. "Enrichment of hepatic progenitor cells from adult mouse liver." Kyoto University, 2004. http://hdl.handle.net/2433/147490.
Full textCATALANO, GIORGIA. "Human liver stem cells and derived products in experimental models of liver ischemia reperfusion injury and of liver isolated normothermic perfusion." Doctoral thesis, Politecnico di Torino, 2018. http://hdl.handle.net/11583/2711047.
Full textDeng, Jie. "Neurogenesis of adult stem cells from the liver and bone marrow." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0009700.
Full textTypescript. Title from title page of source document. Document formatted into pages; contains 143 pages. Includes Vita. Includes bibliographical references.
Vyas, Samir Kumar. "Stromelysin-1 and hepatic stellate cells." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242487.
Full textBerrie, C. P. "Modulation of calcium signalling in acinar cells and hepatocytes." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357366.
Full textEng, Heather Sui-Fong. "Evaluating the use of cryopreserved hepatocytes for the prediction of in vivo hepatic clearance /." See Full Text at OhioLINK ETD Center (Requires Adobe Acrobat Reader for viewing), 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1091638312.
Full textTypescript. "A thesis [submitted] as partial fulfillment of the requirements of the Master of Science degree in Pharmaceutical Sciences." Bibliography: leaves 64-68.
Moolman, Francis Sean. "Oxygen carriers for a novel bio-artificial liver support system." Pretoria : [s.n.], 2003. http://upetd.up.ac.za/thesis/available/etd-09092004-162043.
Full textTitle from opening screen (viewed Oct. 06, 2004). Summaries in English and Afrikaans. Includes bibliographical references (leaves 144-151).
Gaça, Marianna Danuta Aleksandria. "The bi-directional relationship between mast cells and hepatic stellate cells in liver fibrosis." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323958.
Full textGolding, Matthew Christian Henry Max. "The behaviour of liver epithelial cells during regeneration and carcinogenesis." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266028.
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