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Rodriguez-Natal, Alberto, Marc Portoles-Comeras, Vina Ermagan, Darrel Lewis, Dino Farinacci, Fabio Maino, and Albert Cabellos-Aparicio. "LISP: a southbound SDN protocol?" IEEE Communications Magazine 53, no. 7 (July 2015): 201–7. http://dx.doi.org/10.1109/mcom.2015.7158286.
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Balan, T., D. Robu, and F. Sandu. "LISP Optimisation of Mobile Data Streaming in Connected Societies." Mobile Information Systems 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/9597579.
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Mobility mechanisms are key elements of “always connected” smart environments. Since the first mobile IPv4 protocols, the IP mobility solutions have evolved from host mobility to network mobility and migration to IPv6, but there are still use-cases to be covered, especially for redundant multihomed scenarios. Also mobility does not refer only to hosts or individuals, but also to code/applications and to virtual machines. LISP (Locator/Identifier Separation Protocol) can contribute to new solutions for both host mobility and virtual machine mobility (e.g., inside enterprise data centers) by the separation of the identifier and location of a network endpoint. The aim of this paper is to propose a LISP based multihome and load-balanced network architecture for urban environments. Validation is done in an emulated environment for the case of an enterprise with distributed locations, but, furthermore, we extrapolate to other mobile urban scenarios, like the case of providing reliable load-balanced and secured Internet in Public Transportation Systems, with a proposal for an open-source implementation.
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Flatt, Matthew, Taylor Allred, Nia Angle, Stephen De Gabrielle, Robert Bruce Findler, Jack Firth, Kiran Gopinathan, et al. "Rhombus: A New Spin on Macros without All the Parentheses." Proceedings of the ACM on Programming Languages 7, OOPSLA2 (October 16, 2023): 574–603. http://dx.doi.org/10.1145/3622818.
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Rhombus is a new language that is built on Racket. It offers the same kind of language extensibility as Racket itself, but using traditional (infix) notation. Although Rhombus is far from the first language to support Lisp-style macros without Lisp-style parentheses, Rhombus offers a novel synthesis of macro technology that is practical and expressive. A key element is the use of multiple binding spaces for context-specific sublanguages. For example, expressions and pattern-matching forms can use the same operators with different meanings and without creating conflicts. Context-sensitive bindings, in turn, facilitate a language design that reduces the notational distance between the core language and macro facilities. For example, repetitions can be defined and used in binding and expression contexts generally, which enables a smoother transition from programming to metaprogramming. Finally, since handling static information (such as types) is also a necessary part of growing macros beyond Lisp, Rhombus includes support in its expansion protocol for communicating static information among bindings and expressions. The Rhombus implementation demonstrates that all of these pieces can work together in a coherent and user-friendly language.
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Anisul, A. M., and Hannu Flinck. "A Compact Routing based Mapping System for the Locator/ID Separation Protocol (LISP)." International Journal of Computer Applications 127, no. 5 (October 15, 2015): 1–8. http://dx.doi.org/10.5120/ijca2015906380.
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Balan, Titus, Dan Robu, and Florin Sandu. "Multihoming for Mobile Internet of Multimedia Things." Mobile Information Systems 2017 (2017): 1–16. http://dx.doi.org/10.1155/2017/6965028.
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Mobility, redundancy, and bandwidth requirements are transforming the communication models used for IoT, mainly in case of Critical Communications and multimedia streaming (“IoMT, Internet of Multimedia Things”), as wireless video traffic is expected to be 60–75% of the global mobile traffic by 2020. One of the characteristics of 5G networks will be the proliferation of different/heterogeneous radio networks (virtualized radio access networks, RAN, new energy-efficient radios, femtocells, and offloading capabilities) and the possibility for IoT objects to connect and load-balance between dual and multiple RANs. This paper focuses on the possibility of using LISP (Locator Identifier Separation Protocol) for multihoming and load-balancing purposes and presents an illustrative scenario for the case of mobile IoT (e.g., the “things” part of vehicular or public transportation systems, PTS) that are also intensive bandwidth consumers, like the case of connected multimedia “things.” We have implemented and tested a demonstrator of a mobile LISP IoT gateway that is also integrated with Cloud-based video analytics.
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Agyemang, Justice Owusu, Jerry John Kponyo, James Dzisi Gadze, Henry Nunoo-Mensah, and Dantong Yu. "A Lightweight Messaging Protocol for Internet of Things Devices." Technologies 10, no. 1 (January 29, 2022): 21. http://dx.doi.org/10.3390/technologies10010021.
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The move towards intelligent systems has led to the evolution of IoT. This technological leap has over the past few years introduced significant improvements to various aspects of the human environment, such as health, commerce, transport, etc. IoT is data-centric; hence, it is required that the underlying protocols are scalable and sufficient to support the vast D2D communication. Several application layer protocols are being used for M2M communication protocols such as CoAP, MQTT, etc. Even though these messaging protocols have been designed for M2M communication, they are still not optimal for communications where message size and overhead are of much concern. This research paper presents a Lightweight Messaging Protocol (LiMP), which is a minified version of CoAP. We present a detailed protocol stack of the proposed messaging protocol and also perform a benchmark analysis of the protocol on some IoT devices. The proposed minified protocol achieves minimal overhead (a header size of 2 bytes) and has faster point-to-point communication from the benchmark analysis; for communication over LAN, the LiMP-TCP outperformed the CoAP-TCP by an average of 21% whereas that of LiMP-UDP was over 37%. For a device to remote server communication, LiMP outperformed CoAP by an average of 15%.
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Wang, Sainan, Long Zhang, Zhiwei Sun, Daxin Dai, and Kunchi Hou. "A New Quantum Sealed-Bid Auction Protocol with a Set of Local Indistinguishable Orthogonal Product States." Photonics 10, no. 7 (July 12, 2023): 807. http://dx.doi.org/10.3390/photonics10070807.
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Quantum sealed-bid auction (QSA) is a special form of transaction with significant applications in the economic and financial fields. Using a unique set of locally indistinguishable orthogonal product (LIOP) states, we propose a new QSA protocol in this paper. In the protocol, the bid message is encoded as a quantum sequence of LIOP states, and the different particles of LIOP states are transmitted separately. Even though an attacker obtains a portion of the particles, they cannot recover the entire bid message because of the local indistinguishability of LIOP states. Once the auctioneer announces the winner’s bid, all bidders are able to confirm the authenticity of their bid. With the help of a semi-honest third party, collusion between the auctioneer and a malicious bidder can be discovered. Finally, our protocol is capable of meeting all requirements for secure sealed-bid auctions through security and completeness analysis. Additionally, the proposed protocol does not require any entangled resources and complicated operations, so it can be easily implemented in practice.
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Theys, Stéphanie, and Raphael Olszewski. "Cone beam computed tomography (CBCT) in pediatric dentistry." NEMESIS 25, no. 1 (August 7, 2022): 1–43. http://dx.doi.org/10.14428/nemesis.v25i1.67713.
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Objective: The aims of this systematic review of the literature were to investigate the uses of cone beam computed tomography (CBCT) in pediatric dentistry and, if possible, identify the indications.
Material and methods: A literature search was conducted using the PubMed and Scopus electronic databases and the keywords "CBCT and pediatric dentistry". This search provided us with 1518 references. The selected publications were all clinical articles written in French or English and referring to a pediatric population. After screening, 461 eligible full text articles remained.
Results: In total, there were 169 references that met the inclusion criteria. Different topics, mainly relating to orthodontics, anatomy, and cleft lips and palate, were discussed. There was large variability in the information concerning the
technical parameters. The radiographic protocols that we analyzed showed a large heterogeneity.
Conclusions: The level of evidence provided by our work is limited because only two randomized double-blind controlled studies are included. Two indications can be distinguished: for orthodontics and for the rehabilitation of cleft lips and palate. There are a multitude of radiographic protocols. More research is needed to identify other potential clinical indications as well as to determine a standard CBCT protocol for children and adolescents.
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Theys, Stéphanie, and Raphael Olszewski. "Cone beam computed tomography (CBCT) in pediatric dentistry." NEMESIS 25, no. 1 (August 7, 2022): 1–43. http://dx.doi.org/10.14428/nemesis.v25i1.67713.
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Objective: The aims of this systematic review of the literature were to investigate the uses of cone beam computed tomography (CBCT) in pediatric dentistry and, if possible, identify the indications.
Material and methods: A literature search was conducted using the PubMed and Scopus electronic databases and the keywords "CBCT and pediatric dentistry". This search provided us with 1518 references. The selected publications were all clinical articles written in French or English and referring to a pediatric population. After screening, 461 eligible full text articles remained.
Results: In total, there were 169 references that met the inclusion criteria. Different topics, mainly relating to orthodontics, anatomy, and cleft lips and palate, were discussed. There was large variability in the information concerning the
technical parameters. The radiographic protocols that we analyzed showed a large heterogeneity.
Conclusions: The level of evidence provided by our work is limited because only two randomized double-blind controlled studies are included. Two indications can be distinguished: for orthodontics and for the rehabilitation of cleft lips and palate. There are a multitude of radiographic protocols. More research is needed to identify other potential clinical indications as well as to determine a standard CBCT protocol for children and adolescents.
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Ma, Kun, Antoine Bagula, Clement Nyirenda, and Olasupo Ajayi. "An IoT-Based Fog Computing Model." Sensors 19, no. 12 (June 21, 2019): 2783. http://dx.doi.org/10.3390/s19122783.
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The internet of things (IoT) and cloud computing are two technologies which have recently changed both the academia and industry and impacted our daily lives in different ways. However, despite their impact, both technologies have their shortcomings. Though being cheap and convenient, cloud services consume a huge amount of network bandwidth. Furthermore, the physical distance between data source(s) and the data centre makes delays a frequent problem in cloud computing infrastructures. Fog computing has been proposed as a distributed service computing model that provides a solution to these limitations. It is based on a para-virtualized architecture that fully utilizes the computing functions of terminal devices and the advantages of local proximity processing. This paper proposes a multi-layer IoT-based fog computing model called IoT-FCM, which uses a genetic algorithm for resource allocation between the terminal layer and fog layer and a multi-sink version of the least interference beaconing protocol (LIBP) called least interference multi-sink protocol (LIMP) to enhance the fault-tolerance/robustness and reduce energy consumption of a terminal layer. Simulation results show that compared to the popular max–min and fog-oriented max–min, IoT-FCM performs better by reducing the distance between terminals and fog nodes by at least 38% and reducing energy consumed by an average of 150 KWh while being at par with the other algorithms in terms of delay for high number of tasks.
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Neiva, Flavia, and Haydee Wertzner. "A protocol for oral myofunctional assessment: For application with children." International Journal of Orofacial Myology 22, no. 1 (November 1, 1996): 8–19. http://dx.doi.org/10.52010/ijom.1996.22.1.2.
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The purpose of this research was to compare Oral Myofunctional Disorder characteristics in subjects with Tongue Thrust and in subjects with no such disorder, and to suggest a protocol for Oral MyofunctionalAssessment, involving the most relevant characteristics for this diagnosis. The present study used 36 subjects with various disorders enrolled in the Speech-Language Pathology Department at Health Center "Escola Professor Samuel Barnsley Pessoa". Results showed that the main characteristics differentiating subjects with Oral Myofunctional Disorders from those without it and, therefore important diagnostic considerations, are: hole in the feeding-bottle, nipple used in the feeding-bottle, breathing deviations, lips rest posture (information obtained from a person responsible for the subject), lips and tongue resting posture (information obtained from assessment), lip tonus, hard palate, swallow, breathing and occlusion.
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Beleti Junior, Alcides, Ana Carolina Nogueira Bientinez Basile, and Helena Bittar Abrantes. "Técnica Lady Lips para construção transformadora dos lábios." Orofacial Harmony 1, no. 1 (April 15, 2023): 59–66. http://dx.doi.org/10.14436/oh.1.1.059-066.
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O papel dos lábios na construção de uma face harmoniosa vem sendo discutido há muitos anos, assim como as características dos lábios equilibrados. Diversas técnicas para construir ou recuperar os lábios ideais já foram desenvolvidas. Contudo, a necessidade de individualizar os tratamentos, trazendo saúde e beleza para os lábios dos pacientes, levou os presentes autores a estudarem e desenvolverem a técnica Lady Lips. Os princípios desse protocolo foram embasados no preparo tecidual para criar espaço para adequação do preenchedor, após bioestimulação de colágeno local. Assim, o presente estudo tem como objetivo descrever o protocolo dessa técnica, que permite construir lábios harmoniosos, de forma individualizada para cada paciente. É importante compreender esse protocolo, suas indicações e a aplicabilidade da técnica, para torná-la segura e reproduzível, promovendo maior grau de satisfação dos pacientes submetidos a esse tipo de harmonização facial.
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Wang, Shibin, and Nianmin Yao. "LIAP: A local identity-based anonymous message authentication protocol in VANETs." Computer Communications 112 (November 2017): 154–64. http://dx.doi.org/10.1016/j.comcom.2017.09.005.
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Templin, Ludivine, Camille Grosse, Virginie Andres, Clotilde Robert, Laurence Fayol, Umberto Simeoni, and Farid Boubred. "A Quality Improvement Initiative to Reduce the Need for Mechanical Ventilation in Extremely Low Gestational Age Neonates." American Journal of Perinatology 34, no. 08 (January 31, 2017): 759–64. http://dx.doi.org/10.1055/s-0037-1598106.
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Objective Limiting early intubation and mechanical ventilation in extremely low gestational age neonates (ELGAN) may decrease neonatal morbidity and mortality. The aim of our study was to demonstrate the feasibility, efficacy, and tolerability of a delivery room respiratory management protocol, including delayed umbilical cord clamping (DUCC) in combination with optimized nCPAP with high PEEP levels and less invasive surfactant administration (LISA). Study Design This cohort quality improvement study analyzed the respiratory and neonatal outcomes of all consecutive infants born between 24+0 and 26+6 weeks' gestation before (period 1, n = 40) and after (period 2, n = 52) implementing the new protocol. Results Compared with the period 1 infants, the period 2 infants had a lower rate of intubation in the delivery room (31 vs. 90%, p = 0.001) and were less likely to need mechanical ventilation on day 3 (28 vs. 62%, p = 0.002) and during the hospital stay (75 vs. 92.5%, p < 0.05). The two groups did not differ in terms of mortality or neonatal morbidity. Conclusion A delivery room respiratory management protocol based on DUCC, optimized nCPAP with high PEEP levels, and LISA procedure is both feasible and safe, and improved ELGAN respiratory outcomes.
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Uldahl, Mette, Louise Bundgaard, Jan Dahl, and Hilary Mary Clayton. "Assessment of Skin and Mucosa at the Equine Oral Commissures to Assess Pathology from Bit Wear: The Oral Commissure Assessment Protocol (OCA) for Analysis and Categorisation of Oral Commissures." Animals 12, no. 5 (March 3, 2022): 643. http://dx.doi.org/10.3390/ani12050643.
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This study addresses the presence and location of natural pigmentation, potentially pathological changes in pigment, interruptions of the natural lining (scars), roughness, and erosions/contusion (bruising) in and around the corners of the lips of 206 horses presented to a veterinarian for routine preventative dental treatment. After sedation, photographs were taken and later evaluated for the presence of lesions. During the photographic analysis, the Oral Commissure Assessment (OCA) protocol was developed to map precisely the areas of skin and mucosa around the corners of the lips, and the presence of lesions was recorded for each area. Potentially pathological pigment changes occurred more frequently in horses with a higher level of training (p = 0.04) and in light-coloured horses (p = 0.0004), but there was no association with the current use of a bit or the discipline that the horse participated in (p = 0.20). Scars occurred more frequently in horses competing at a higher level. Only two horses had contusions or erosions, five had ulcers, and none showed bleeding; these numbers were too low for statistical analysis. Using the OCA protocol provides a detailed method for categorizing and recording lesions in and around the corners of the lips, including natural vs. potential and/or definite pathological character.
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Morte-Nadal, Tamara, and Miguel Angel Esteban-Navarro. "Digital Competences for Improving Digital Inclusion in E-Government Services: A Mixed-Methods Systematic Review Protocol." International Journal of Qualitative Methods 21 (January 2022): 160940692110709. http://dx.doi.org/10.1177/16094069211070935.
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The e-government requires citizens that have a certain level of digital skills. Contact restrictions caused by the COVID-19 pandemic has accelerated the digital transformation of Public Administration in most countries and has increased the social digital divide. Therefore, the training of citizens in digital competences is one of the main challenges of the knowledge society. This mixed-methods systematic review protocol aims to synthesize quantitative and qualitative findings about conditioning factors of digital inclusion, in a multidimensional perspective, related with the education, healthcare and welfare sectors and the political actions involved to improve the digital competences of citizenship for allowing and enhancing their interactions with these online public services. The protocol has been written following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. Nine databases including Web of Science, Scopus, Educational Resources Information Center Library and Information Science Abstracts (LISA), ProQuest, MEDLINE, PubMed, SocINDEX and Cairn.info will be searched for peer-reviewed empirical studies published from 2011 or later. Grey literature and citation chaining will be undertaken. Quantitative, qualitative and mixed-methods studies will be included. Data items will be extracted and coded in a standardized format. A convergent segregated approach to synthesis and integration will be used. The results will be of interest to educational policymakers who want to take into account citizens’ digital skills in the design of online services and lifelong learning programs.
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Pablo, Gonzalez. "Fractional CO2 Laser Treatment after Transvaginal Polypropilene Mesh for Urinary Incontinence and Pelvic Organ Prolapse Treatment as an Alternative to Improove Mesh Erosion Rates." International Journal of Innovative Research in Medical Science 6, no. 12 (December 6, 2021): 904–7. http://dx.doi.org/10.23958/ijirms/vol06-i12/1285.
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The support advantages of synthetic mesh in vaginal reconstructive surgery and stress urinary incontinence are significant. However, erosion of the mesh may occur as a complication, Four sessions of fractional CO2 Laser treatment protocol (Mona Lisa Touch Deka M.E.L.A Florence Italy protocol, were performed in the study group to 96 patients, beginning at 30 days, after mesh insertion, important improvement regarding erosion rates was found inside our study group, thanks to the trophic effects of fractional CO2 laser protocol. The use of alternative technologies that provide bio -stimulation of vaginal epithelium by increasing its thickness, and trophic changes that may be related to the very low erosion rate was found in our group of patients
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Fernandes, Tauane Catilza Lopes, and Shaline Séfara Lopes Fernandes. "Extração de proteínas de tecidos de animais pelo protocolo SDS 2%." Research, Society and Development 9, no. 10 (October 27, 2020): e9379109453. http://dx.doi.org/10.33448/rsd-v9i10.9453.
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Em condições territoriais extensas do Brasil há muitas necessidades de recursos para realização de pesquisas. Muitas Universidades Federais e Estaduais dependem de recursos para investir em tecnologias para análise em sistemas biológicos. Inovações que permitam diminuir os custos na execução da pesquisa, torna-las práticas a nível de campo e responsivas na realização da pesquisa. Para isso foi proposto um protocolo de extração de proteínas a base de dodecil sulfato de sódio (SDS) a 2% com o intuito de diminuir a quantidade de solventes orgânicos utilizados, sem prejudicar a viabilidade das proteínas, a viabilidade de outras técnicas de análise proteômica: SDS-PAGE e Espectrometria de massas, justamente pela diminuição do acúmulo de resíduos produzidos pela lise celular. Considerando o SDS como componente no processo SDS-PAGE, este não causa acúmulo de resíduo por solventes orgânicos externos a técnica, além de baratear os custos e de reduzir o efeito toxicológico em laboratório. Os resultados obtidos mostraram que este protocolo se mostra viável para extração de proteínas de tecidos de animais, comprovada pela técnica SDS-PAGE que permitiu a visualização nítida dos fragmentos das proteínas extraídas e ausência de rastros proteicos provenientes ao excesso de lise celular.
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Knepper, Kerstin, and Stefan Bräse. "Buchbesprechung: Combinatorial Library Methods and Protocols. Herausgegeben von Lisa Bellavance English." Angewandte Chemie 115, no. 20 (May 23, 2003): 2313. http://dx.doi.org/10.1002/ange.200390487.
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Tsongalis, G. J., A. H. McPhail, R. D. Lodge-Rigal, J. F. Chapman, and L. M. Silverman. "Localized in situ amplification (LISA): a novel approach to in situ PCR." Clinical Chemistry 40, no. 3 (March 1, 1994): 381–84. http://dx.doi.org/10.1093/clinchem/40.3.381.
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Abstract Amplification of specific gene target sequences has become a routine molecular procedure in a variety of laboratories. When coupled with either a direct or indirect method of detecting amplified product, in situ amplification offers an extremely powerful investigative tool. We describe a protocol for a localized in situ amplification (LISA) reaction that includes tissue-culture cloning rings and allows for the amplification of gene target sequences in specific regions of paraffin-embedded tissue sections. Digoxigenin-11-dUTP was added to the amplification reaction and thus incorporated into the amplified products, providing a mechanism by which direct nonisotopic detection could be performed. To demonstrate the approach, LISA was performed on known positive Pneumocystis carinii rat lung tissues, with primers specific for the P. carinii rRNA gene sequence.
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Ines, Felix, Shandee Hutson, Katherine Coughlin, Andrew Hopper, Anamika Banerji, Cherry Uy, Neil Finer, et al. "Multicentre, randomised trial of preterm infants receiving caffeine and less invasive surfactant administration compared with caffeine and early continuous positive airway pressure (CaLI trial): study protocol." BMJ Open 11, no. 1 (January 2021): e038343. http://dx.doi.org/10.1136/bmjopen-2020-038343.
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Introduction Respiratory distress syndrome (RDS) or surfactant deficiency occurs primarily in premature infants resulting in composite outcomes of death or bronchopulmonary dysplasia. Initial management strategies for preterm infants with RDS includes early initiation of continuous positive airway pressure (CPAP) and titration of fractional inspired oxygen (FiO2), and may include the use of less invasive surfactant administration (LISA) to avoid the need for mechanical ventilation. In order to optimise success of non-invasive support, the use of early caffeine therapy may be critical to the success of LISA. The objective of our trial is to evaluate whether infants that receive early caffeine, CPAP and surfactant via the LISA method compared with infants that receive caffeine and CPAP alone, have a decreased need for invasive mechanical ventilation in the first 72 hours of life. Methods and analysis CaLI is an unblinded multicentre, randomised controlled, trial of 180 preterm infants (24+0–29+6 weeks corrected GA). Criteria for intubation/treatment failure will follow guidelines for the management of RDS, including: (1) CPAP level of 6–8 cmH20 and FiO2>0.40 required to maintain saturations 90%–95% for 2 hours after randomisation; (2) a pH of 7.15 or less or a paCO2>65 mm Hg on any (2) blood gases (arterial/capillary/or venous) at least 2 hours after randomisation and in the first 72 hours of life; (3) continued apnoea/bradycardia/desaturation events despite nasal intermittent minute ventilation mode of ventilation. Infants will be randomised by 1 hour of life and caffeine/LISA treatments administered by 2 hour of life. Caffeine will be administered prior to surfactant in the LISA arm and before 2 hours of life in the control arm. Ethics and dissemination Chiesi Farmaceutici, S.p.A is the sponsor of CaLI. Ethical approval has been obtained. Results will be submitted for publication in peer reviewed journals. Trial registration number www.Clinicaltrials.gov:NCT04209946; Pre-results.
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Gómez-Meire, Silvana, César Gabriel Márquez, Eliana Patricia Aray-Cappello, and José R. Méndez. "Using Live Spam Beater (LiSB) Framework for Spam Filtering during SMTP Transactions." Applied Sciences 12, no. 20 (October 18, 2022): 10491. http://dx.doi.org/10.3390/app122010491.
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This study introduces the Live Spam Beater (LiSB) framework for the execution of email filtering techniques during SMTP (Simple Mail Transfer Protocol) transactions. It aims to increase the effectiveness and efficiency of existing proactive filtering mechanisms, mainly based on simple blacklists. Since it implements some proactive filtering schemes (during SMTP transaction), when an email message is classified as spam, the sender can be notified by an SMTP response code as a result of the transaction itself. The presented framework is written in Python programming language, works as an MTA (Mail Transfer Agent) server that implements an SMTP (Simple Mail Transfer Protocol) reverse proxy and allows the use of plugins to easily incorporate new filtering techniques designed to operate proactively. We also include a plugin to perform proactive content-based filtering through the analysis of words included in the body of the email message. Finally, we measured the performance of the plugin and the framework (time required for operation and accuracy) obtaining values suitable for their use during SMTP transactions.
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Lima Aires Gomes, Giselle Pinheiro, Adriana Arruda Barbosa Rezende, Íris Lima Silva, Joana D’Arc Ponce de Almeida Ponde de Almeida, and Heron Beresford. "Cuidados de enfermagem dispensados aos pacientes com tubo orotraqueal: avaliação realizada em unidade de terapia intensiva." Revista de Enfermagem UFPE on line 3, no. 4 (September 14, 2009): 808. http://dx.doi.org/10.5205/reuol.581-3802-1-rv.0304200903.
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Objective: to evaluate the care dispensed by the nursing team of the Intensive Care Unit of the Hospital Public of Gurupi to patients using orotracheal tube. Methods: this is about a descriptive, observational research, from quantitative analysis. The observation of care, according to the protocol aimed at the handling of the endotracheal tube, occurred for seven days in March 2009 for 14 hours a day, with a total of 105 hours. The study was approved by the Research Ethics Committee of the University Castelo Branco (0169/2008). Results: checking blood pressure of the cuff every 12 hours and hydration of the lips every four hours was not performed by nursing staff, the oral hygiene was performed only once a day, but was assured by professionals an alternative means of communication intubated patients, the exchange and holding the lace was made daily, the use of gauze on the sides of the oral cavity was placed when it was apparent some aggression to the skin of the patient, the aspiration of endotracheal tube with aseptic technique, was performed to avoid complications. Conclusion: the nursing team observed presented failures in attendance which could be reduced through implanting specific protocols for handling of the orotracheal tube. Descriptors: intubation; nursing care; intensive care unit.
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Knepper, Kerstin, and Stefan Bräse. "Book Review: Combinatorial Library Methods and Protocols. Edited by Lisa Bellavance English." Angewandte Chemie International Edition 42, no. 20 (May 23, 2003): 2215. http://dx.doi.org/10.1002/anie.200390460.
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Narayanan, V. P., and S. H. Adenwalla. "Notch-free vermillion after unilateral cleft lip repair: The Charles Pinto centre protocol." Indian Journal of Plastic Surgery 41, no. 02 (July 2008): 167–70. http://dx.doi.org/10.1055/s-0039-1699260.
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ABSTRACTA notch on the vermillion is one of the most common complications following the repair of a unilateral cleft lip. Several methods have been described for the secondary correction of a notch. However, there are only a few reports on how the notch can be prevented during primary lip repair. Causes of a vermillion notch were analysed at the Charles Pinto Centre for Cleft Lip and Palate and each possible cause addressed by an appropriate procedure. This protocol was then followed in every patient. In this manner, we have been able to avoid notches in unilateral cleft lips altogether and more significantly, junior trainees in our department have also been able to consistently avoid a notch in their repairs.
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Anam, Moh Khoirul, Farasandya Amalia Hapsari, and Riska Nur Yunita sari. "MENGATASI KETERLAMBATAN MENULIS DAN MEMBACA SISWA SEKOLAH DASAR DENGAN METODE BIBIKU LISA (Bimbingan Khusus Menulis dan Membaca)." Edukasia : Jurnal Pendidikan 10, no. 2 (December 27, 2023): 31–41. http://dx.doi.org/10.35334/eduborneo.v10i2.4707.
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ABSTRAK Penelitian ini merupakan penelitian ini adalah pendekatan kualitatif. Penelitian ini menggunakan pendekatan kualitatif karena dalam melakukan tindakan kepada subyek penelitian yang sangat diutamakan adalah mengungkapkan makna, yakni makna dan proses pembelajaran sebagai upaya meningkatkan motivasi, minat, dan prestasi belajar melalui tindakan yang dilakukan. Penelitian ini bertujuan untuk mendeskrpsikan cara penulis dalam mengatasi keterlambatan Menulis dan Membaca Siswa Kelas Tinggi di SDN Triwung Lor 2. Siswa yang diteliti atau dibimbing sebanyak sebanyak 6 siswa. Adapun aturan yang diberlakukan oleh SDN Triwung Lor 2 dalam pelaksanaan pembelajaran tatap muka pasca pandemi covid-19 diantaranya sebagai berikut: a) Menerapkan Protokol Kesehatan. b) Pembelajaran Tatap Muka dilakukan dengan seratus persen kehadiran. c) Pelaksanaan pembelajaran disesuaikan dengan kurikulum yang digunakan. dan d) Kegiatan ekstrakulikuler dan olahraga dapat dilakukan di ruang terbuka. Faktor utama diselenggarakannya pembelajaran dengan menggunakan Jurus Bibiku Lisa yaitu dikarenakan siswa kehilangan semangat belajar (learnning loss). Kelebihan Pembelajaran menggunakan Jurus Bibiku Lisa dalam mengatasi keterlambatan Menulis dan Membaca Siswa ini yaitu sebagai berikut. Pertama, keterlibatan siswa dalam pembelajaran semakin tinggi. Kedua, siswa bisa merasakan seperti belajar di kelas privat. Ketiga, lebih efektif dan efisien. Keempat, lebih fresh dalam pembelajaran. Kata Kunci: Learnning Loss, Jurus Bibiku Lisa, Covid-19 ABSTRACT This research is a qualitative approach. This research uses a qualitative approach because in taking action on research subjects the priority is to express meaning, namely the meaning and learning process as an effort to increase motivation, interest and learning achievement through the actions taken. This research aims to describe the author's way of overcoming the writing and reading delays of high class students at SDN Triwung Lor 2. There were 6 students studied or supervised. The rules implemented by SDN Triwung Lor 2 in implementing face-to-face learning after the Covid-19 pandemic include the following: a) Implementing Health Protocols. b) Face-to-face learning is carried out with one hundred percent attendance. c) Implementation of learning is adjusted to the curriculum used. and d) Extracurricular activities and sports can be carried out in open spaces. The main factor in holding learning using Bibiku Lisa's moves is because students lose their enthusiasm for learning (learning loss). The advantages of learning using my Aunt Lisa's technique in overcoming students' writing and reading delays are as follows. First, student involvement in learning is increasing. Second, students can feel like studying in a private class. Third, more effective and efficient. Fourth, be fresher in learning. Keywords: Learning Loss, Jurus Bibiku Lisa, Covid-19
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Fisher, M., V. Kurilin, and S. Sennikov. "AB0093 MODELING OF ANTIGEN-COLLAGEN-INDUCED ARTHRITIS IN BALB/c MICE." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1178.1–1178. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4575.
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BackgroundRheumatoid arthritis (RA) is one of the most common autoimmune diseases. Currently, disease-modifying drugs and biological agents are used to treat RA [1]. The available drugs are not perfect: they have serious side effects and do not always cause a stable improvement or remission [2]. The above sets the task of finding new approaches to treatment that will be effective, more specific and safe. In this connection, it is necessary to develop and apply experimental models as close as possible in pathogenesis to rheumatoid arthritis. One such model, rarely used at present, is the combined antigen-collagen-induced arthritis [3].ObjectivesTo show immunological and histological changes similar to RA in the AIA/CIA model and the validity of its application in research activities.MethodsExperimental AIA/CIA was induced according to 2 different protocols in 50 BALB/c mice. Clinical assessment of arthritis was made by measuring the swelling of the paws with a caliper at different times. The assessment of immunological changes included the analysis of the content of antibodies to type II collagen by ELISA, the content of T-regulatory cells by flow cytometry. Also, a histological analysis of the obtained data was carried out.ResultsOn the 10th day, a significant increase in paw thickness was recorded in animals induced both according to the first and second protocols. The intensity of swelling subsided by the 23rd day. A significant increase in the content of antibodies to type II collagen was observed in all experimental groups, but in animals from Protocol No. 1, the amount of antibodies to type II collagen was significantly higher. A high level of T-regulatory cells was registered only in mice induced according to the first protocol on the 10th day. Histological changes in the form of synovial hyperplasia, pannus, usurations were observed to varying degrees in all experimental groups, but the most pronounced changes were in animals from the first protocol.ConclusionIn experimental animals, in all the presented protocols, changes were observed that were closest to RA, when compared with classical models of experimental arthritis induction. Based on the fact that protocol 1 animals showed an increase in the content of T-regulatory cells, the levels of antibodies to type 2 collagen were consistently high, and the histological changes were the most pronounced, it can be assumed that protocol 1 of the combined AIA/CIA model on the line of Balb/c mice, is the most suitable for testing and developing new methods of RA therapy.References[1]Abbasi M, Mousavi MJ, Jamalzehi S, Alimohammadi R, Bezvan MH, Mohammadi H, Aslani S. Strategies toward rheumatoid arthritis therapy; the old and the new. J Cell Physiol. 2019 Jul;234(7):10018-10031. doi: 10.1002/jcp.27860. Epub 2018 Dec 7. PMID: 30536757.[2]Greenberg JD, Reed G, Kremer JM, Tindall E, Kavanaugh A, Zheng C, Bishai W, Hochberg MC; CORRONA Investigators. Association of methotrexate and tumour necrosis factor antagonists with risk of infectious outcomes including opportunistic infections in the CORRONA registry. Ann Rheum Dis. 2010 Feb;69(2):380-6. doi: 10.1136/ard.2008.089276. Epub 2009 Apr 8. PMID: 19359261; PMCID: PMC2861900.[3]Baddack U, Hartmann S, Bang H, Grobe J, Loddenkemper C, Lipp M, Müller G. A chronic model of arthritis supported by a strain-specific periarticular lymph node in BALB/c mice. Nat Commun. 2013;4:1644. doi: 10.1038/ncomms2625. PMID: 23552059; PMCID: PMC3644064Disclosure of InterestsNone declared
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Kessler, Michael C., Erin Jackson, and Joseph T. Newsome. "Response to Protocol Review Scenario: Loose lips can sink ships—and potentially careers and institutions." Lab Animal 45, no. 9 (August 23, 2016): 328–29. http://dx.doi.org/10.1038/laban.1089.
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Rho, Nark-Kyoung, Boncheol Leo Goo, Seong-Jae Youn, Chong-Hyun Won, and Kwang-Ho Han. "Lip Lifting Efficacy of Hyaluronic Acid Filler Injections: A Quantitative Assessment Using 3-Dimensional Photography." Journal of Clinical Medicine 11, no. 15 (August 4, 2022): 4554. http://dx.doi.org/10.3390/jcm11154554.
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The study aimed to compare the volume enhancement and the lifting capacity of two different hyaluronic acid gels for lip injection. Thirty-six Korean female patients were randomized into two groups according to the cross-linking degree of the hyaluronic acid filler injected. Using a fixed injection protocol, patients were injected with 1 mL of hyaluronic acid filler in the lips and followed up at four and 12 weeks after injection. Lip volume, lip projection, and columella–labial angle were measured using a 3-dimensional imaging system at each time point. Follow-up values were compared with baseline. Compared with pre-treatment values, there was a statistically significant increase in mean lip volume and lip projection at four and 12 weeks after injection, with no significant differences between the two groups. Lips injected with hyaluronic acid filler of intermediate cross-link density resulted in more acute angles than lips injected with lightly cross-linked hyaluronic acid. The difference was statistically significant at each follow-up time point. No serious complications were observed throughout the study period. Our results imply that in patients who want a prominent upper lip lift, lip injections using hyaluronic acid fillers with intermediate cross-linking density can be a good option due to their lift capacity. The degree of cross-linking may not be a significant determinant of simple lip volume augmentation when other variables are constant.
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Ozturk, Mustafa, Sukru Ozaydin, Basak Oyan, Murat Ozbalak, Fikret Arpaci, Semra Paydas, Selmin Ataergin, et al. "The comparison of up-front autologous peripheral stem cell transplantation in first remission and long-lasting intensive chemotherapy protocols in highly aggressive non-Hodgkin’s lymphomas: Results of a retrospective analysis." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 6550. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.6550.
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6550 Background: Optimal therapy in adult patients with Burkitt’s and lymphoblastic lymphoma are still unknown. Despite long–lasting and intensive chemotherapy protocols, post-transplant relapse is common and the chemotherapy period is time consuming. Methods: In this retrospective study, the results of induction and consolidation chemotherapies followed-by high dose therapy (HDT) and autologous peripheral stem cell transplantation (APSCT) (n=21), which was given in a time period of 3 months were compared to long–lasting and intensive chemotherapy protocols (LICP) (n=39) in patients with Burkitt’s and Lymphoblastic lymphoma, without bone marrow or central nervous system involvement at presentation. Cyclophosphamide, vincristine, prednisolone, doxorubicin (Adriamycin) with or without L–asparaginase were given as induction chemotherapy, followed-by a consolidation chemotherapy with DHAP and up-front HDT. Results: More than 60% of patients in both groups were in the intermediate and high risk group according to International Prognostic Index. There was no significantly difference according to age, gender, bulky disease, stage, Burkitt’s and Lymphoblastic lymphoma ratio in both groups (p>0,05). Median follow up was 32,3 months (min-max: 0-229 months). When HDT and LICP groups were compared: CR achieved in 76,3% and 82,1% of patients (p>0,05); Median PFS was 10,4 months (min-max: 6,1-20,3) and 10,1 months (min-max: 6,3- 69,0) (p>0,05); One year overall survival rate was 64,7% and 74,4% and five year overall survival rate was 50,1% and 56,7% (p>0,05) respectively. Conclusions: The current study suggests that induction and consolidation chemotherapies followed by HDT and APSCT have similar CR, PFS and OS rates when compared to more time consuming LICP therapies. This provides a short period of treatment with a high rate of survival in adult patients with highly aggressive lymphomas in first remission.
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Cameron, Sharon, and Harvey Dillon. "The Listening in Spatialized Noise–Sentences Test (LISN-S): Comparison to The Prototype Lisn and Results From Children With Either a Suspected (Central) Auditory Processing Disorder or a Confirmed Language Disorder." Journal of the American Academy of Audiology 19, no. 05 (May 2008): 377–91. http://dx.doi.org/10.3766/jaaa.19.5.2.
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Background: The Listening in Spatialized Noise—Sentences test (LISN-S®) is a revised version of the Listening in Spatialized Noise (Continuous Discourse) test (LISN®; Cameron et al, 2006a). The software produces a three-dimensional auditory environment under headphones and was developed to assess auditory stream segregation skills in children. A simple repetition response protocol is utilized to determine speech reception thresholds (SRTs) for sentences presented from 0° azimuth in competing speech. The competing speech is manipulated with respect to its location in auditory space (0° vs. + and −90° azimuth) and the vocal quality of the speaker(s) (same as, or different to, the speaker of the target stimulus). Performance is measured as two SRT and three advantage measures. The advantage measures represent the benefit in dB gained when either talker, spatial, or both talker and spatial cues combined are incorporated in the maskers. Purpose: To document LISN-S performance in a group of nine children with suspected (central) auditory processing disorder ([C]APD), who presented with difficulties hearing in the classroom in the absence of any routine audiological or language, learning or attention deficits to explain such a difficulty (SusCAPD group). The study also aimed to research the effect of higher-order deficits on LISN-S performance in a group of 11 children with a range of documented learning or attention disorders (LD Group). Correlation between performance on the LISN-S and a traditional (C)APD test battery was also compared. Research Design: In a descriptive design, SusCAPD and LD group performance on the LISN-S was compared to published normative data from 70 age-matched controls. A correlational design was used to compare performance on the various tests in the traditional (C)APD battery to the SRT and advantage measures of the LISN-S. Results: There were no significant differences between the SusCAPD, LD, or control groups on the conditions of the LISN-S where both the target and maskers emanated from 0° azimuth (low-cue SRT, p = 0.978; talker advantage, p = 0.307). However, there were significant differences between groups on the performance measures where the maskers were separated from the target by + and −90°. Post hoc tests revealed that there were no significant differences between the LD group and controls on any of these measures. There were, however, significant differences between the SusCAPD group and the controls on all the conditions where the maskers were spatially separated from the target (high-cue SRT, p = 0.001; spatial advantage, p < 0.0001; total advantage, p < 0.0001). The LISN-S did not correlate significantly with any test in the traditional test battery, nor were the nonspatial and spatial performance measures of the LISN-S correlated. Conclusions: The study supports the hypothesis that a high proportion of children with suspected (C)APD have a deficit in the mechanisms that normally use the spatial distribution of sources to suppress unwanted signals. The LISN-S is a potentially valuable assessment tool for assessing auditory stream segregation deficits, and is sensitive in differentiating various forms of auditory streaming.
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Brown, David K., Sharon Cameron, Jeffrey S. Martin, Charlene Watson, and Harvey Dillon. "The North American Listening in Spatialized Noise—Sentences Test (NA LiSN-S): Normative Data and Test-Retest Reliability Studies for Adolescents and Young Adults." Journal of the American Academy of Audiology 21, no. 10 (November 2010): 629–41. http://dx.doi.org/10.3766/jaaa.21.10.3.
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Background: The Listening in Spatialized Noise—Sentences test (LiSN-S; Cameron and Dillon, 2009) was originally developed to assess auditory stream segregation skills in children aged 6 to 11 yr with suspected central auditory processing disorder. The LiSN-S creates a three-dimensional auditory environment under headphones. A simple repetition-response protocol is used to assess a listener's speech reception threshold (SRT) for target sentences presented in competing speech maskers. Performance is measured as the improvement in SRT in dB gained when either pitch, spatial, or both pitch and spatial cues are incorporated in the maskers. A North American-accented version of the LiSN-S (NA LiSN-S) is available for use in the United States and Canada. Purpose: To develop normative data for adolescents and adults on the NA LiSN-S, to compare these data with those of children aged 6 to 11 yr as documented in Cameron et al (2009), and to consolidate the child, adolescent, and adult normative and retest data to allow the software to be used with a wider population. Research Design: In a descriptive design, normative data and test-retest reliability data were collected. Study Sample: One hundred and twenty normally hearing participants took part in the normative data study (67 adolescents aged 12 yr, 1 mo, to 17 yr, 10 mo, and 53 adults aged 19 yr, 10 mo, to 30 yr, 30 mo). Forty-nine participants returned between 1 and 4 mo after the initial assessment for retesting. Participants were recruited from sites in Cincinnati, Dallas, and Calgary. Results: When combined with data collected from children aged 6 to 11 yr, a trend of improved performance as a function of increasing age was found across performance measures. ANOVA (analysis of variance) revealed a significant effect of age on performance. Planned contrasts revealed that there were no significant differences between adults and children aged 13 yr and older on the low-cue SRT; 14 yr and older on talker and spatial advantage; 15 yr and older on total advantage; and 16 yr and older on the high-cue SRT. Mean test-retest differences on the various NA LiSN-S performance measures for the combined child, adult, and adolescent data ranged from 0.05 to 0.5 dB. Paired comparisons revealed test-retest differences were not significant on any measure of the NA LiSN-S except low-cue SRT. Test-retest differences across measures did not differ as a function of age. Test and retest scores were significantly correlated for all NA LiSN-S measures. Conclusions: The ability to use either spatial or talker cues in isolation becomes adultlike by about 14 yr of age, whereas the ability to combine spatial and talker cues does not fully mature until closer to adulthood. By consolidating child, adolescent, and adult normative and retest data the NA LiSN-S can now been utilized to assess auditory processing skills in a wider population.
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Cameron, Sharon, Helen Glyde, and Harvey Dillon. "Listening in Spatialized Noise—Sentences Test (LiSN-S): Normative and Retest Reliability Data for Adolescents and Adults up to 60 Years of Age." Journal of the American Academy of Audiology 22, no. 10 (November 2011): 697–709. http://dx.doi.org/10.3766/jaaa.22.10.7.
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Background: The Australian version of the Listening in Spatialized Noise—Sentences Test (LiSN-S) was originally developed to assess auditory stream segregation skills in children aged 6 to 11 yr with suspected central auditory processing disorder. The LiSN-S creates a three-dimensional auditory environment under headphones. A simple repetition-response protocol is used to assess a listener's speech reception threshold (SRT) for target sentences presented in competing speech maskers. Performance is measured as the improvement in SRT in decibels gained when either pitch, spatial, or both pitch and spatial cues are incorporated in the maskers. Purpose: To collect additional normative data on the Australian LiSN-S for adolescents and adults up to 60 yr of age, to analyze the effects of age on LiSN-S performance, to examine retest reliability in the older population, and to extrapolate findings from the Australian data so that the North American version of the test can also be used clinically with older adults. Research Design: In a descriptive design, normative and test–retest reliability data were collected from adolescents and adults and combined with previously published data from Australian children aged 6 to 11 yr. Study Sample: One hundred thirty-two participants with normal hearing aged 12 yr, 0 mo, to 60 yr, 7 mo, took part in the normative data study. Fifty-five participants returned between 2 and 4 mo after the initial assessment for retesting. Results: Analysis of variance revealed a significant effect of age on LiSN-S performance (p < .01 for all LiSN-S measures, ηp 2 ranging from 0.16 to 0.54). On the low and high cue SRT measures, planned contrasts revealed significant differences between adults and children aged 13 yr and younger, as well as between 50- to 60-yr-olds and younger adults aged 18–29 yr. Whereas there were significant differences between adults and children on the talker, spatial, and total advantage measures, there were no significant differences in performance in adults aged 18–60 yr. There was a small but significant improvement on retest ranging from 0.5 to 1.2 dB across the four LiSN-S test conditions (p ranging from .01 to <.001). However, there was no significant difference between test and retest on the advantage measures (p ranging from .143 to .768). Test–retest differences across all LiSN-S measures were significantly correlated (r ranging from 0.2 to 0.7, p ranging from .023 to <.00000001) and did not differ as a function of age (p ranging from .178 to .980). Conclusions: As there was no significant difference among adults aged 18–60 yr on the LiSN-S talker, spatial, and total advantage measures, it appears that the decline in ability to understand speech in noise experienced by 50- to 60-yr-olds is not related to their ability to use either spatial or pitch cues. This result suggests that some other factor/s contributes to the decline in speech perception in noise experienced by older adults that is reported in the literature and was demonstrated in this study on the LiSN-S low and high cue SRT measures.
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Menozzi, Oliva, Eugenio Di Valerio, Clara Tamburrino, Abdulrahim Saleh Shariff, Vincenzo d'Ercole, and Maria Giorgia Di Antonio. "A race against time: monitoring the necropolis and the territory of Cyrene and Giarabub through protocols of remote sensing and collaboration with Libyan colleagues." Libyan Studies 48 (September 28, 2017): 69–103. http://dx.doi.org/10.1017/lis.2017.13.
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AbstractThe core area of Cyrene, despite recent upheavals, benefits from well-managed controls and fences that so far seem to have stopped the looting, although not the vandalism. These fences act mainly as a psychological barrier; for the local people, everything inside the fences is seen as ‘more important’ than what is outside. However, it is impossible to enclose all the monumental tombs, rock-cut sanctuaries and ancient farms and fortifications. The first type of damage we see is due to looting, which is increasing, and acts of vandalism. The lack of regulation and police control as well as increased urbanisation have caused a lot of uncontrolled building, causing the further destruction of large sections of the necropolis. A second type of damage is due to the lack of maintenance. In order to help restore the sites, the Universities of Urbino, Chieti, Roma 3, Naples 2 and the Mission of the MIBACT at Giarabub, in collaboration with the DoA, have organised courses on ‘Rescue restoration in emergency’. Despite the growing number of inspectors and technicians in Cyrene, there are still not enough archaeologists, guards or restorers. This paper explains these general issues and, as a case study, the remote but important area of Giarabub.
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Mackwin Kenwood, Dmello, Sanjeev Badiger, Sudeep Kumar, Kumar N., D’Souza N., and Purushotam J. "Use of spatial analytics and geographic information systems in childhood diarrhoea in rural areas of India: A protocol paper." Biomedicine 42, no. 6 (December 31, 2022): 1237–42. http://dx.doi.org/10.51248/.v42i6.961.
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Introduction and Aim: The most recent advancement in epidemiology is using Geographic Information Systems (GIS) to comprehend illness based on clustering and spatial analysis. Using spatial analysis has shown positive changes in sanitation, reducing diarrhoea's burden. This study put forwards the methodology used to analyze spatiotemporal clustering and hotspot areas of childhood diarrhea in Karkala taluk, Udupi during 2015 to 2018. Materials and Methods: This study describes the methods used to analyze the space-time clustering and local indicators of spatial association (LISA) of childhood diarrhoea using the GeoDa and SaTScan programmes. At the Karkala taluk, data on under-five diarrhoea was gathered throughout time and space to develop the geospatial models. While the timing of the onset of the diarrhoea impacts the temporal characteristics, the child's position at the time of the event determines the spatial characteristics. The child's location and time of diarrheal episode was considered for the geospatial analysis. Results: The Kulldorff scan statistic (SaTScan v10.1) was employed for geographical analysis, and GeoDa software used for LISA and hotspot analysis. The randomness distribution of childhood diarrhoea over time and space was determined using the Kulldorff scan statistic software. The SaTScan locates and evaluates the statistical significance of geographical clusters based on the number of cases inside and outside the cylinder window. The scanning window in the software uses a cylinder with an elliptical or circular base to study intervals for time, space, and space-time. The different combinations of High and Low categories of the spatial association are covered by the hotspot analysis utilizing the GeoDa software. Conclusion: To build data-driven public health decision-making, it is required to link spatial and temporal patterns of diarrheal incidence among under-five children with predictive variables derived from routine data.
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Alempijevic, Djordje, Slobodan Savic, Vesna Kesic, Ivanka Baralic, and Goran Ilic. "Physical examination of sexual assault victims in Belgrade area." Srpski arhiv za celokupno lekarstvo 134, no. 9-10 (2006): 408–13. http://dx.doi.org/10.2298/sarh0610408a.
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Introduction: Sexual crimes represent various forms of contact of perpetrator?s genitals, lips, tongue, and fingers with genitals, lips and/or anus of the victim, in order to achieve sexual satisfaction, without victim?s consent. Objective: The aim of this work was to analyze the type of medical institution in which victims of sexual assaults are being examined in Belgrade area, to assess the quality of these examinations and medical records, as well as to control whether standardized protocols are followed. Method: Data were obtained through analysis of 113 cases of sexual assaults prosecuted in the District Court of Belgrade. Results: All victims were females with mean age of 24.1 years. The majority of victims (85%) were examined in one medical institution, most often in the Institute of Gynecology and Obstetrics, Clinical Center of Serbia, and only by one medical doctor (81.4%). Gynecologists were most frequently included in examination, while specialists of forensic medicine were engaged in only 9 cases (7.9%). In 84% of victims, the examination was performed during the first three days after the assault, and in 52% of cases on the first day. Standard techniques of clinical and gynecological examinations were applied only, without following any protocols, so the reports were made exclusively on individual basis. In no case an informed consent by victim was obtained before examination. Anamnestic data were collected in only 15.9% of cases, and they were generally incomplete. Conclusion: The results of investigation show that the quality of examination of sexual assault victims in Belgrade area is not adequate. Therefore, such negative practice should be changed in future through introduction of standardized protocols for examination of victims, as well as development of clinical forensic medicine.
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Portuguese, Andrew J., Aya Albittar, Emily C. Liang, Jennifer J. Huang, Alexandre V. Hirayama, Erik L. Kimble, Lorenzo Iovino, et al. "Lisocabtagene Maraleucel Versus Axicabtagene Ciloleucel: Efficacy and Toxicity in a Real-World Setting." Blood 142, Supplement 1 (November 28, 2023): 2131. http://dx.doi.org/10.1182/blood-2023-172978.
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CD19 CAR-T therapy has revolutionized the management of high-risk and relapsed/refractory (R/R) large B-cell lymphoma (LBCL) but remains limited by significant toxicities leading to morbidity/mortality and high resource utilization. Single-arm studies have suggested differences in efficacy and toxicity across FDA-approved CD19 CAR-T products. A matching-adjusted indirect treatment comparison showed comparable efficacy and more favorable safety with lisocabtagene maraleucel (liso-cel) compared to axicabtagene ciloleucel (axi-cel), but was limited to clinical trial patients (pts) and suffered from an absence of patient-level data (Maloney, J Hematol Oncol, 2021). In the absence of randomized clinical trial data, adjusted comparative analyses using pt-level data are critically needed to guide product choice. Therefore, we retrospectively evaluated the impact of CAR-T product type on the outcomes of 129 LBCL pts receiving liso-cel or axi-cel per standard of care. All LBCL pts treated at our center with liso-cel or axi-cel outside of a clinical trial between 1/2018 and 5/2023 were included. Best response was determined within 3 months of CAR-T infusion by PET-CT imaging per Lugano 2014 criteria. Cytokine release syndrome (CRS) and immune-effector cell-associated neurotoxicity syndrome (ICANS) were graded using ASTCT criteria. Of 129 total pts, 37% (n=48) and 63% (n=81) received liso-cel and axi-cel, respectively. Seven pts received out-of-specification liso-cel on an expanded access protocol. Pts who received liso-cel were older (median 67 vs 62 years, p=.003). Other baseline characteristics, including male sex (liso-cel vs axi-cel: 63% vs 69%, p=.4), HCT-CI score (1.0 vs 1.0, p=.6), pre-lymphodepletion (LD) LDH (178 vs 214 U/L, p=.14) and ALC (0.65 vs 0.60 x 10³/µL, p=.3), largest lesion diameter (3.1 vs 3.0 cm, p=.4), and extranodal disease (56% vs 56%, p>.9) were similar. The vein-to-vein time (time from leukapheresis to CAR-T infusion) was longer for liso-cel: median, 35 vs 27 days (p<.001). After liso-cel, the total inpt duration was shorter (median, 5 vs 14 days, p<.001) and fewer pts had ≥2 admissions (8.3% vs 22%, p=0.043). In pts with measurable disease prior to LD (n=113), we observed comparable efficacy with liso-cel vs axi-cel: ORR, 82% vs 77% (p=.5); CR, 56% vs 51% (p=.8). After a median follow-up of 17.7 months, we observed comparable 1-year outcomes with liso-cel vs axi-cel: duration of response (DOR), 56% vs 61% (p=.7); progression-free survival (PFS), 47% vs 47% (p=.99; Figure); and overall survival (OS), 69% vs 60% (p=.39). In pts evaluable for toxicity assessment (n=129), liso-cel was associated with lower rates of CRS and ICANS compared to axi-cel: any grade CRS, 62% vs 88% (p=.001); ICANS any grade, 32% vs 56% (p=.010); days with fever, median 2 vs 5 days (p<.001). Grade 3-4 CRS, 2.1% vs 9.9% (p=.2) or grade 3-4 ICANS, 23% vs 19% (p=0.5) were similar. We measured lower peak serum inflammatory markers after liso-cel: CRP, 58 vs 114 mg/L (p<.001); ferritin, 622 vs 1,315 ng/mL (p=0.007); IL-6, 55 vs 204 pg/mL (p=.010); and D-dimer, 1.4 vs 2.4 mg/L (p=.017). The incidence of infectious complications after liso-cel vs axi-cel was as follows: bacteremia: 6% vs 9% (p=.7); CMV viremia: 13% vs 6.2% (p=.3). Post-infusion median nadir cytopenias were less severe after liso-cel: ANC, 0.32 vs 0.04 x 10³/µL (p<.001); Plt, 69 vs 35 x 10³/µL (p=.003); and Hgb, 8.9 vs 8.2 g/dL (p<.001). Fewer pts developed severe neutropenia after liso-cel: 72% vs 93% (p=0.002). In multivariable analysis including pre-LD LDH and ALC, largest lesion diameter, age and HCT-CI score, we could not confirm an independent impact of the product type on CR, PFS, or OS ( Table). However, axi-cel remained independently associated with a higher odds of any grade CRS (adjusted OR [aOR] 4.56, 95% CI 1.65-13.5, p=.004) and any grade ICANS (aOR 3.44, 95% CI 1.42-8.85, p=.008). Our analysis of CD19 CAR-T therapy for R/R LBCL in the non-trial setting showed similar rates of durable responses following liso-cel and axi-cel. Pts who received liso-cel were older, with otherwise comparable baseline characteristics. Although liso-cel was associated with less toxicity, its vein-to-vein time was longer. In multivariable analyses, pre-LD LDH and largest lesion diameter were the only factors independently associated with response outcomes. We conclude that liso-cel is a robust alternative to other CD19 CAR-T products in older and frailer LBCL pts.
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Jayet, Jérémie, Jennifer Canonge, Frédéric Heim, Marc Coggia, Nabil Chakfé, and Raphaël Coscas. "Mechanical Comparison between Fenestrated Endograft and Physician-Made Fenestrations." Journal of Clinical Medicine 12, no. 15 (July 26, 2023): 4911. http://dx.doi.org/10.3390/jcm12154911.
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Introduction: A fenestrated endograft (FE) is the first-line endovascular option for juxta and pararenal abdominal aortic aneurysms. A physician-modified stent-graft (PMSG) and laser in situ fenestration (LISF) have emerged to circumvent manufacturing delays, anatomic standards, and the procedure’s cost raised by FE. The objective was to compare different fenestrations from a mechanical point of view. Methods: In total, five Zenith Cook fenestrations (Cook Medical, Bloomington, IN, USA) and five Anaconda fenestrations (Terumo Company, Inchinnan, Scotland, UK) were included in this study. Laser ISF and PMSG were created on a Cook TX2 polyethylene terephthalate (PET) cover material (Cook Medical, Bloomington, IN, USA). In total, five LISFs and fifty-five PMSG were created. All fenestrations included reached an 8 mm diameter. Radial extension tests were then performed to identify differences in the mechanical behavior between the fenestration designs. The branch pull-out force was measured to test the stability of assembling with a calibrated 8 mm branch. Fatigue tests were performed on the devices to assess the long-term outcomes of the endograft with an oversized 9 mm branch. Results: The results revealed that at over 2 mm of oversizing, the highest average radial strength was 33.4 ± 6.9 N for the Zenith Cook fenestration. The radial strength was higher with the custom-made fenestrations, including both Zenith Cook and Anaconda fenestrations (9.5 ± 4.7 N and 4.49 ± 0.28 N). The comparison between LISF and double loop PMSG highlighted a higher strength value compared with LISF (3.96 N ± 1.86 vs. 2.7 N ± 0.82; p= 0.018). The diameter of the fenestrations varied between 8 and 9 mm. As the pin caliber inserted in the fenestration was 9 mm, one could consider that all fenestrations underwent an “elastic recoil” after cycling. The largest elastic recoil was observed in the non-reinforced/OC fenestrations (40%). A 10% elastic recoil was observed with LISF. Conclusion: In terms of mechanical behavior, the custom-made fenestration produced the highest results in terms of radial and branch pull-out strength. Both PMSG and LISF could be improved with the standardization of the fenestration creation protocol.
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Mostovoi, A. V., A. L. Karpova, N. R. Kharitonova, O. V. Avdei, M. A. Kovaleva, A. S. Petrova, M. V. Kondratyev, et al. "MORBIDITY AND PREDICTORS OF LETHAL OUTCOME IN PREMATURE INFANTS WHO RECEIVED PORACTANT ALPHA WITH GESTATION AGE OF LESS THAN 32 WEEKS." Pediatria. Journal named after G.N. Speransky 101, no. 1 (February 18, 2022): 27–38. http://dx.doi.org/10.24110/0031-403x-2022-101-1-27-38.
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The aim of the study – to analyze the morbidity and search for predictors of death in premature infants with a gestational age (GA) of 32 weeks or less, born in perinatal centers and received Poractant alfa (PA) in the treatment of respiratory distress syndrome (RDS), in order to improve the quality of medical care for premature babies. Materials and methods of research: a multicenter prospective open-label non-randomized continuous comparative study was conducted in five perinatal centers from 2020 to 2021. A total of 264 patients, and inclusion criteria: GA less than 32 weeks, the need for PA replacement therapy in the first minutes of life, the first dose of PA – 200 mg/kg, the second dose of PA – 100 mg/kg, strict adherence to the study protocol. Children who did not require PA therapy in the delivery room, who received other types of surfactants, as well as those with congenital malformations, genetic and/or chromosomal abnormalities, early neonatal sepsis, and deviations from the study protocol were excluded. Children were divided into 3 groups: group 1 (200 children) – invasive PA (ETT), group 2 (19 children) – PA injection by INSURE method, group 3 (45 children) – PA injection by LISA method. Results: the median birth weight of all 264 children was 1090.0 g, GA – 28.0 weeks. The median age of the first PA injection is 10.0 [10.0; 10.0] min of life. PA was reintroduced in 20.1% (53/264) of children, invasive mechanical ventilation (IV) was required in 82.6% (218/264) of cases, high-frequency oscillatory mechanical ventilation (HFOV) – in 24.0% (59/264 ). The incidence of bronchopulmonary dysplasia was 37.5% (99/264) of cases and prevailed in the ETT group in comparison with LISA (43.0% versus 27.0%, respectively, p=0.043) and INSURE (43.0% versus 5.0 %, p=0.001). Predictors of death were low gestational age and birth weight, surgical stage of necrotizing enterocolitis, hemodynamically significant patent ductus arteriosus, grade III intraventricular hemorrhage, and pulmonary hemorrhage. The development of the latter in the first 72 hours of life increases the risk of death by 19.7 times. Conclusions: minimally invasive administration of PA by INSURE and LISA methods associated with reduce of morbidity and improves outcomes in premature infants who less than 32 weeks of GA. Pulmonary hemorrhage was the most dangerous among the predictors of death, increasing the risk of death by almost 20 times.
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Devi, T. Shobbana. "Indian Board of Orthodontics Case Report: Management of Class II Skeletal Malocclusion Using 2-Phase Treatment." Journal of Indian Orthodontic Society 55, no. 4 (October 2021): 418–23. http://dx.doi.org/10.1177/03015742211055910.
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KL, a 12-year-old boy, presented with a class II Div I malocclusion on a class II skeletal base (retrognathic mandible) with a 7-mm overjet and a horizontal growth pattern. He had a convex profile, incompetent lips, lip trap, deep mentolabial sulcus, everted lower lip, and positive visual treatment objective (VTO). KL had a CS2 cervical maturation stage, which indicates 65% to 85% adolescent growth remaining. Treatment involved growth modification using a removable Twin Block with midpalatal expansion screw. This was followed by upper and lower fixed appliance using 0.022” × 0.028” slot Mclaughlin Bennet and Trevisi (MBT) prescription. The retention protocol involved upper wrap around and lower lingual bonded retainer.
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Carvalho, Adriana Rahal Rebouças de, and Luana De Aguiar Gonçalves. "Adenoamigdalectomia: comparação das funções orofaciais em crianças antes e depois cirurgia / Adenotonsillectomy: comparison of orofacial functions in before and after surgery children." Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo 64, no. 1 (April 25, 2019): 40. http://dx.doi.org/10.26432/1809-3019.2019.64.1.040.
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Introdução: As alterações nas diversas funções orofaciais, como respiração, mastigação, deglutição, fala e voz tem sido cada vez mais comum de encontrarmos em crianças. Respiradores orais são mais propícios a esse tipo de alteração, e, muitas vezes, é necessário realizar amigdalectomia, adenoidectomia ou ambas. Muitos são os casos em que não há melhora das funções orofaciais mesmo após a cirurgia. Objetivo: avaliar as diferenças nas funções: respiração, mastigação e deglutição, na postura e nas estruturas orofaciais em crianças antes e depois de realizar adenoamigdalectomia. Método: realizou-se em oito crianças, avaliação clínica, por meio do protocolo de Avaliação em Motricidade Orofacial da Clínica de Fonoaudiologia da Faculdade de Ciências Médicas da Santa Casa de São Paulo. A primeira avaliação aconteceu um dia antes da cirurgia no Ambulatório de Otorrinolaringologia da Instituição (Faculdade de Ciências Médicas da Santa Casa de São Paulo) e a segunda 20 dias após a cirurgia, na data em que a criança retornou com o otorrinolaringologista, no mesmo local. O teste estatístico utilizado para análise de dados nominais pareados foi o McNemar. Resultados: apesar dos resultados não terem sido estatisticamente significantes, houve melhora nos aspectos como mobilidade de lábios, língua e bochechas, e tônus de lábios, língua e bochechas depois da cirurgia. Nas funções de respiração e deglutição obtivemos uma diferença discreta entre o antes e depois da cirurgia, entretanto, a função de mastigação permaneceu a mesma. Conclusão: conclui-se que as funções orofaciais de respiração, mastigação e deglutição, além da postura e das estruturas orofaciais não apresentaram significância estatística quando comparadas antes e depois da cirurgia de adenoamigdalectomia. Mesmo assim foi observado melhora depois da cirurgia na respiração e deglutição, assim como nos aspectos de mobilidade de lábios, língua e bochechas; tônus de lábios, língua e bochechas. Descritores: Respiração Bucal, Mastigação, Deglutição, Fonoaudiologia, CriançaAbstractIntroduction: Changes in various orofacial functions, such as breathing, chewing, swallowing, speech and voice, have been increasingly common in children. Oral breathers are more amenable to this type of alteration, and tonsillectomy, adenoidectomy, or both are often necessary. There are many cases in which there is no improvement in orofacial functions even after surgery. Objective: to evaluate the differences in functions: breathing, chewing and swallowing, posture and orofacial structures in children before and after performing adenotonsillectomy. Method: it was performed in 8 children, clinical evaluation, by means of the Orofacial Motricity Assessment protocol of the Speech Therapy Clinic of Faculdade de Ciências Médicas da Santa Casa de São Paulo. The first evaluation occurred one day before the surgery in the Otorhinolaryngology Outpatient Clinic of Faculdade de Ciências Médicas da Santa Casa de São Paulo and the second 20 days after surgery, on the date the child returned with the otorhinolaryngologist, in the same place. Results: Eight children were evaluated using the McNemar test, a statistical test used for paired nominal data. The results were not statistically significant. However, there was improvement in aspects such as mobility of lips, tongue and cheeks, and tonus of lips, tongue and cheeks. In the functions of breathing and swallowing we obtained a small pre and post surgical difference, however, the chewing function remained the same. Conclusion: it was concluded that the orofacial functions of breathing, chewing and swallowing, besides posture and orofacial structures did not present statistical significance when compared before and after the adenotonsillectomy surgery. Even so, improvement after surgery on breathing and swallowing was observed, as well as mobility aspects of the lips, tongue and cheeks; tonus of lips, tongue and cheeks.Keywords: Mouth breathing; Mastication; Deglutition; Speech, language and hearing science; Child
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Ilenko, Nataliya M., Ella V. Nikolishyna, Iryna Yu Lytovchenko, and Fardin Atash Bar. "COMPLEX THERAPY OF ATOPIC CHEILITIS." Wiadomości Lekarskie 74, no. 2 (2021): 310–12. http://dx.doi.org/10.36740/wlek202102125.
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The aim: Was to evaluate clinical data after the use of pimecrolimus (1% cream “Elidel”) in patients with mild and moderate severity of atopic cheilitis, according to modern therapeutic requirements. There was an algorithm of treatment the patients with cheilitis proposed it based on the data from literary sources and personal clinical experience. Materials and methods: 22 patients with atopic cheilitis aged from 19 to 40 agreed on a clinical examination in accordance with the protocol of the study. Patients were prescribed “Elidel” in the form of 1% cream for lubrication of the affected areas of the skin and lips, and antihistamine “Erius”, for the normalization of the general condition used sedatives and vitamins after consultation of specialists in the general profile. Results: Patients of both groups during the re-examination after 3, 7, 10 days recorded a positive dynamics of the red border of the lips and skin: a significant reduction in the inflammatory process, normalization of indicators of general blood analysis, improvement in the overall quality of life of patients. Conclusions: The results of treatment allow to consider 1% cream “Elidel” (pimecrolimus) as a preparation of choice in the complex treatment of patients with atopic cheilitis of mild and moderate severity.
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Armogida, Niccolò Giuseppe, Alessandra Valletta, Elena Calabria, Federica Canfora, Carlo Rengo, and Gianrico Spagnuolo. "The Photocoagulation-Assisted Aesthetic Treatment of Phlebectasias of the Lips Using a Nd:YAG Laser with a Low Energy Level." Journal of Clinical Medicine 12, no. 6 (March 15, 2023): 2292. http://dx.doi.org/10.3390/jcm12062292.
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Venous lakes (VLs) are benign malformations often localized in the lips, therefore impacting the self-confidence of patients. In the present study, the use of a Nd:YAG laser according to a defined protocol with a low level of absolute energy (4.9 J) is proposed for the treatment of VLs of the lips. A total of 47 patients with 50 labial VL were treated with a Nd:YAG in one laser session without local anesthesia. The area reduction was evaluated according to the Vlachakis criteria 7 and 30 days after the laser application. Additionally, oral discomfort was rated according to the Numeric Rating Scale (NRS) during and 24 hours after the procedure. All patients achieved complete clinical healing within 30 days after the laser application. In particular, patients with VL with a diameter ≤ 6 mm (62.1%) achieved a complete resolution after 7 days (p-value < 0.001). Such patients reported little or no discomfort (NRS 0 to 3) during the laser session and no discomfort after 24 hours (p-value < 0.001). No major complications were reported, and no recurrence was observed at 2-year follow-up. These findings suggest that Nd:YAG laser treatment could be an effective and well-tolerated approach to the aesthetic treatment of labial VL.
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Russell, Grant, Marina Kunin, Mark Harris, Jean-Frédéric Levesque, Sarah Descôteaux, Catherine Scott, Virginia Lewis, et al. "Improving access to primary healthcare for vulnerable populations in Australia and Canada: protocol for a mixed-method evaluation of six complex interventions." BMJ Open 9, no. 7 (July 2019): e027869. http://dx.doi.org/10.1136/bmjopen-2018-027869.
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IntroductionAccess to primary healthcare (PHC) has a fundamental influence on health outcomes, particularly for members of vulnerable populations. Innovative Models Promoting Access-to-Care Transformation (IMPACT) is a 5-year research programme built on community-academic partnerships. IMPACT aims to design, implement and evaluate organisational innovations to improve access to appropriate PHC for vulnerable populations. Six Local Innovation Partnerships (LIPs) in three Australian states (New South Wales, Victoria and South Australia) and three Canadian provinces (Ontario, Quebec and Alberta) used a common approach to implement six different interventions. This paper describes the protocol to evaluate the processes, outcomes and scalability of these organisational innovations.Methods and analysisThe evaluation will use a convergent mixed-methods design involving longitudinal (pre and post) analysis of the six interventions. Study participants include vulnerable populations, PHC practices, their clinicians and administrative staff, service providers in other health or social service organisations, intervention staff and members of the LIP teams. Data were collected prior to and 3–6 months after the interventions and included interviews with members of the LIPs, organisational process data, document analysis and tools collecting the cost of components of the intervention. Assessment of impacts on individuals and organisations will rely on surveys and semistructured interviews (and, in some settings, direct observation) of participating patients, providers and PHC practices.Ethics and disseminationThe IMPACT research programme received initial ethics approval from St Mary’s Hospital (Montreal) SMHC #13–30. The interventions received a range of other ethics approvals across the six jurisdictions. Dissemination of the findings should generate a deeper understanding of the ways in which system-level organisational innovations can improve access to PHC for vulnerable populations and new knowledge concerning improvements in PHC delivery in health service utilisation.
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Palomba, M. Lia, Jacob Garcia, Lei Wang, Christine Dehner, Karen C. Chung, and David G. Maloney. "TRANSCEND: Lisocabtagene Maraleucel (liso-cel; JCAR017) Healthcare Resource Utilization in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)." Blood 132, Supplement 1 (November 29, 2018): 3545. http://dx.doi.org/10.1182/blood-2018-99-119387.
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Abstract Background: Relapsed/refractory (R/R) DLBCL is associated with high healthcare resource utilization (HRU) and cost (Danese 2017). Patients with R/R DLBCL have poor outcome with median OS <10 months (Van den Neste 2015). As transformative therapies are being developed for these patients, resource utilization may become an issue. Liso-cel is an investigational defined composition, CD19-directed 4-1BB CAR T cell product administered at a precise dose of CD8 and CD4 CAR T cells in a multicenter, seamless design Phase 1 pivotal trial of (R/R) DLBCL (TRANSCEND NHL 001; NCT02631044). In a recent analysis with 6 months follow-up, liso-cel treatment demonstrated a best overall response rate of 75% (55% CR) with low rates of severe cytokine release syndrome (1%) and neurologic events (13%) (Abramson 2018). The objective of this analysis is to characterize HRU, including site of care, associated with liso-cel in an interim analysis of the TRANSCEND pivotal trial. Methods: Eligible patients with R/R DLBCL, PMBCL, FL grade 3B, or MCL (≥18 years who received ≥2 lines of therapy) and adequate organ function (no minimum ALC requirement for apheresis) received lymphodepletion (LD) with fludarabine and cyclophosphamide, followed by a single flat-dose infusion of liso-cel at one of two dose levels (DL1, 5 × 107 cells; DL2, 1 × 108 cells). Clinical site of care for liso-cel infusion was not protocol-defined. HRU was collected at all sites. Results: 94 patients (91 patients in the efficacy database and 3 patients from the safety database that were not in the electronic clinical as of data cut) were included in the preliminary site of care analysis. 86 patients received liso-cel in the inpatient setting and 8 patients in the outpatient setting. Mean (SD) number of hospital days was 15.6 (9.6) and 9.3 (11.9) among patients receiving inpatient and outpatient liso-cel infusion, respectively, reflecting a 40% lower duration in mean hospital days. The median time to hospitalization following outpatient infusion was 5 days (range: 4-22). No patients infused in the outpatient setting required subsequent ICU care or received corticosteroids, and only one received tocilizumab for cytokine release syndrome (CRS). Of all treated patients in the efficacy database (n=91), 12% (11/91) of patients required ICU care for management of toxicity, including 10% (9/91) for CRS or neurotoxicity and 3% (3/91) for management of acute respiratory events. Rates of hemofiltration and ventilation for patients in this cohort were 2% (2/91) and 7% (6/91), respectively. Outcomes based on site of administration will be presented (based on longer follow-up). Conclusions: CAR T cell therapy represents an additional treatment option for patients with R/R DLBCL. Liso-cel has been infused in both the inpatient and outpatient setting. Outpatient infusion was associated with 40% lower mean hospital days compared with infusions administered in the inpatient setting. As enrollment is ongoing, updated data will be reported. Disclosures Palomba: Celgene: Consultancy; Pharmacyclics: Consultancy. Garcia:Juno Therapeutics, a fully owned subsidiary of Celgene: Employment, Equity Ownership. Wang:Juno Therapeutics, a fully owned subsidiary of Celgene: Employment, Equity Ownership. Dehner:Juno Therapeutics, a fully owned subsidiary of Celgene: Employment, Equity Ownership. Chung:Juno Therapeutics, a fully owned subsidiary of Celgene: Employment. Maloney:Janssen Scientific Affairs: Honoraria; GlaxoSmithKline: Research Funding; Seattle Genetics: Honoraria; Juno Therapeutics: Research Funding; Roche/Genentech: Honoraria.
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Radulova, Petya, Stanislava Hitrova-Nikolova, Liliya Vakrilova, and Violeta Dimitrova. "A New Approach of Several Minimally Invasive Procedures for Improvement of the Outcome in Preterm Infants." Open Access Macedonian Journal of Medical Sciences 10, B (March 29, 2022): 731–35. http://dx.doi.org/10.3889/oamjms.2022.8189.
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BACKGROUND: Based on the last update of European Consensus Guidelines on Management of Respiratory Distress Syndrome, the following study is new for our clinic approach for minimally invasive respiratory support in preterm infants. AIM: The aim is to find out if the implementation of several minimally invasive procedures leads to a reduction of the frequency and severity of chronic complications and improved outcomes in extremely premature infants. MATERIALS AND METHODS: Infants are below 30 gestational weeks, divided into two groups – therapeutic – 37 infants on standardized early respiratory management protocol which includes: High-flow continuous positive airway pressure (20l/min ≥ 15 PEEP) in the delivery room, support of spontaneous breathing and non-invasive mechanical ventilation, avoidance of hypothermia and LISA shortly after birth, and control group – 46 infants that received standard respiratory support (positive pressure ventilation – invasive and non-invasive in the delivery room, most infants ≤ 27 weeks gestational age were intubated and received early surfactant, extubation “when being ready” – usually after few days). RESULTS: The duration of mechanical ventilation, oxygen therapy, and hospital stay is shorter in the therapeutic group (p < 0.05). Severe bronchopulmonary dysplasia is not found in the interventional group, 26% of the patients in the control group have severe form of the disease (p = 0.001). Severe intraventricular hemorrhages are found in 11% of the infants in the therapeutic group and 28% in the control group (p = 0.06). CONCLUSION: Due to the changed protocol, we report increased survival of ELBW infants without severe chronic complications. The acute pulmonary injury, acquired in the perinatal period, is directly connected with the development of BPD. For this reason, all the changes that we introduced in our clinic (heat management, support of spontaneous breathing, “open up” lungs – high flow PEEP/CPAP, and LISA during spontaneous breathing) contribute to the lower frequency of severe chronic complications and high percentage of ELBW infants, who do not develop severe BPD.
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Abdalrahim Sheriff Saad, A., S. Farag Abdel Hati, Sonia Antonelli, Oliva Menozzi, Veronica Petraccia, and Maria Carla Somma. "GIS of the chora of Cyrene: fortifications and Christian buildings in Late Antiquity." Libyan Studies 47 (November 2016): 31–66. http://dx.doi.org/10.1017/lis.2016.7.
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AbstractThe project of mapping the chora of Cyrene, for the team of Chieti University, started between 1999 and 2001 as a layer of a ‘macro-GIS’ of the area to the east of Cyrene, that is, the transect between Cyrene and El-Gubba/Qubbah. Because of the large scale of the area and the monumentality of the sites, the team is composed of several research units based around a large number of scholars and technicians. The project employs a suite of traditional methodologies for the study of landscape archaeology (surveys, GIS mapping, differential GPS, excavations), in combination with technologies integrating the knowledge of the territory (remote sensing on HD satellite photos, geomorphological reconstruction, laser scanning, archaeometric analysis, non-invasive geophysical prospection and infrared diagnostic analysis). The large quantity of data coming from this wide approach has been organised into a flexible and multilayer GIS. A joint team of Libyan and Italian archaeologists and technicians is testing a common protocol for monitoring the monuments and sites in the territory, using surveys and remote sensing analysis, which has intensified during these problematic periods, and regularly analysing satellite sets over the past four years.The project aims to map and document as much as possible in this territory, to identify the location of the region's so-called ‘minor sites’, which are numerous and almost unknown. They were, from the Late Classical to the Islamic periods, vital sites for the management of the local economy. This paper presents the main issues relating to settlements and sites in Late Antiquity, concentrating mainly on fortifications along the limes and basilicas within the area of the transect. Moreover, in the presentation of the data, the GIS approach has been integrated here with data coming both from the remote sensing and from more traditional research approaches, such as planimetrical and typological analysis of the buildings, study of the sources and detailed mapping of the building techniques.
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Parente, Ezequiel Aguiar, Guilherme Bruno Fontes Vieira, Daniel Lucena Landim, Rafael Wendon Rodrigues Rocha, Ivon Teixeira de Souza, Romulo Cesar Costa Barbosa Filho, and Francisco José Cabral Mesquita. "Leiomiossarcoma paratesticular: relato de caso e revisão de literatura." Journal of Health & Biological Sciences 11, no. 1 (July 11, 2023): 1. http://dx.doi.org/10.12662/2317-3076jhbs.v11i1.4721.p1-4.2023.
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Introdução: O leiomiossarcoma é um tumor maligno de células mesenquimais. Este estudo tem como objetivo apresentar um caso clínico de sarcoma paratesticular subtipo leiomiossarcoma, tendo em vista sua escassez na literatura. Relato de caso: Paciente, 40 anos, sexo masculino, negro, hígido, iniciou quadro de dor em região de bolsa escrotal. Foi submetido à ultrassonografia que evidenciou tumor testicular à esquerda. Foi realizada abordagem cirúrgica. Considerações finais: O leiomiossarcoma é um tumor maligno com envolvimento de músculo liso. Devido à raridade do leiomiossarcoma paratesticular, não existe protocolo estabelecido na literatura. A importância da equipe multidisciplinar e especializada com acompanhamento longitudinal tem o intuito de instituir a terapia padrão-ouro e evitar recorrência.
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Cameron, Sharon, David Brown, Robert Keith, Jeffrey Martin, Charlene Watson, and Harvey Dillon. "Development of the North American Listening in Spatialized Noise–Sentences Test (NA LiSN-S): Sentence Equivalence, Normative Data, and Test–Retest Reliability Studies." Journal of the American Academy of Audiology 20, no. 02 (February 2009): 128–46. http://dx.doi.org/10.3766/jaaa.20.2.6.
Full textAbstract:
Background: The Listening in Spatialized Noise–Sentences test (LiSN-S®) was originally developed in Australia to assess auditory stream segregation skills in children with suspected central auditory processing disorder (CAPD). The software produces a three-dimensional auditory environment under headphones. A simple repetition-response protocol is utilized to determine speech reception thresholds (SRTs) for sentences presented from 0 degrees azimuth in competing speech. The competing speech (looped children's stories) is manipulated with respect to its location (0 degrees vs. +90 degrees and −90 degrees azimuth) and the vocal quality of the speaker(s) (same as, or different to, the speaker of the target stimulus). Performance is measured as two SRT and three advantage measures. The advantage measures represent the benefit in dB gained when either talker, spatial, or both talker and spatial cues combined are incorporated in the maskers. Purpose: The objective of this research was to develop a version of the LiSN-S suitable for use in the United States and Canada. The original sentences and children's stories were reviewed for unfamiliar semantic items and rerecorded by native North American speakers. Research Design: In a descriptive design, a sentence equivalence study was conducted to determine the relative intelligibility of the rerecorded sentences and adjust the amplitude of the sentences for equal intelligibility. Normative data and test–retest reliability data were then collected. Study Sample: Twenty-four children with normal hearing aged 8 years, 3 months, to 10 years, 0 months, took part in the sentence equivalence study. Seventy-two normal-hearing children aged 6 years, 2 months, to 11 years, 10 months, took part in the normative data study. Thirty-six children returned between two and three months after the initial assessment for retesting. Participants were recruited from sites in Cincinnati, Dallas, and Calgary. Results: The sentence equivalence study showed that post-adjustment, sentence intelligibility increased by 18.7 percent for each 1 dB increase in signal-to-noise ratio. Analysis of the normative data revealed no significant differences on any performance measure as a consequence of data collection site or gender. Inter- and intra-participant variation was minimal. A trend of improved performance as a function of increasing age was found across performance measures, and cutoff scores, calculated as two standard deviations below the mean, were adjusted for age. Test–retest differences were not significant on any measure of the North American (NA) LiSN-S (p ranging from .080 to .862). Mean test–retest differences on the various NA LiSN-S performance measures ranged from 0.1 dB to 0.6 dB. One-sided critical difference scores calculated from the retest data ranged from 3 to 3.9 dB. These scores, which take into account mean practice effects and day-to-day fluctuations in performance, can be used to determine whether a child has improved on the NA LiSN-S on retest. Conclusions: The NA LiSN-S is a potentially valuable tool for assessing auditory stream segregation skills in children. The availability of one-sided critical difference scores makes the NA LiSN-S useful for monitoring listening performance over time and determining the effects of maturation, compensation (such as an assistive listening device), or remediation.
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Lizalde Hernández, Azucena, Juliana Graciela Vestena Zillmer, María Mercedes Moreno González, and Josefina Valenzuela Gandarilla. "Determinants of parental responsibility to promote healthy eating behaviors in children: a scoping review protocol." Research, Society and Development 10, no. 15 (December 2, 2021): e531101522043. http://dx.doi.org/10.33448/rsd-v10i15.22043.
Full textAbstract:
Introduction: The parental responsibility of parents regarding the feeding of children implies having a responsible job when selecting, preparing and offering food to their children; in addition, qualities of exemplary behavior such as healthy eating behavior that influences the habits that their children acquire; however, there are multiple determining factors that negatively affect it. Objective: To identify the determining factors in the parental responsibility of caregivers to promote an eating behavior in children from 6 months to 12 years old. Methods: The review will be carried out according to the methodology proposed by Hilary Arksey and Lisa O`Malley updated by The Joanna Briggs Institute (JBI) for scoping review. A comprehensive search strategy will be applied with the support of the research librarian to refine the search and locate the studies. Inclusion criteria of quantitative, qualitative and mixed studies will be applied, in titles, abstract and full text; Two reviewers will independently extract the information using a screening tool; finally, the results will be presented narratively and tables or figures will be used. Ethics and disclosure: This scoping review will involve a secondary analysis of the data already collected and therefore does not require ethical approval. The results of this research will be submitted to peer-reviewed journals for publication and will also be disseminated at conferences and seminars.