Dissertations / Theses on the topic 'Lipids'
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Kotland, Vojtěch. "Separace lipidů z buněčných tkání." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2019. http://www.nusl.cz/ntk/nusl-401857.
Full textCvrková, Jana. "Stanovení lipidů a zastoupení mastných kyselin v obilce ječmene." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2010. http://www.nusl.cz/ntk/nusl-216627.
Full textMateos, Diaz Eduardo. "Etude par spectroscopie infrarouge (FTIR) des interactions de la lipase pancréatique apparentée de type 2 (PLRP2) avec les phospholipides et les sels biliaires." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4763.
Full textGuinea pig pancreatic lipase-related protein type 2 (GPLRP2) hydrolyzes a large set of lipid substrates, but displays however some selectivity depending on the supramolecular structure of substrate and the presence of surfactants like bile salts (NaTDC). We used Fourier transform infrared (FTIR) spectroscopy to study the interactions between phospholipids (DPPC), surfactants and GPLRP2 under conditions close to those of the GI tract. To study the adsorption step independently from hydrolysis, a GPLRP2 inactive variant (S152G) was produced. Various phospholipid dispersions were prepared: multilamellar (MLV) and large unilamellar vesicles (LUV) and mixed micelles with surfactants. GPLRP2 was found to hydrolyze DPPC present in mixed DPPC-NaTDC micelles but was inactive on DPPC vesicles and DPPC-Triton X100 micelles. FTIR analysis of GPLRP2 S152G interaction with the DPPC-NaTDC system showed a decrease in the conformational disorder and mobility of the acyl chains, a dehydratation of the interface, and changes in the orientation and H-bonding of DPPC polar head-groups. These effects were not observed with MLV, LUV and DPPC-Triton X100 micelles, thus indicating a specific recognition of DPPC in mixed phospholipid-bile salt micelles, in agreement with phospholipase activity measurements. Changes in the IR spectra during DPPC hydrolysis by GPLRP2 were monitored. Specific spectral features were associated to the production of lipolysis products and could be used for quantifying phospholipid lipolysis by FTIR
Dennison, Andrew. "Neutron reflectivity studies of insulin and phosphatidylcholine floating lipid bilayers." Thesis, University of Sheffield, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574586.
Full textMateos, Diaz Eduardo. "Etude par spectroscopie infrarouge (FTIR) des interactions de la lipase pancréatique apparentée de type 2 (PLRP2) avec les phospholipides et les sels biliaires." Electronic Thesis or Diss., Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4763.
Full textGuinea pig pancreatic lipase-related protein type 2 (GPLRP2) hydrolyzes a large set of lipid substrates, but displays however some selectivity depending on the supramolecular structure of substrate and the presence of surfactants like bile salts (NaTDC). We used Fourier transform infrared (FTIR) spectroscopy to study the interactions between phospholipids (DPPC), surfactants and GPLRP2 under conditions close to those of the GI tract. To study the adsorption step independently from hydrolysis, a GPLRP2 inactive variant (S152G) was produced. Various phospholipid dispersions were prepared: multilamellar (MLV) and large unilamellar vesicles (LUV) and mixed micelles with surfactants. GPLRP2 was found to hydrolyze DPPC present in mixed DPPC-NaTDC micelles but was inactive on DPPC vesicles and DPPC-Triton X100 micelles. FTIR analysis of GPLRP2 S152G interaction with the DPPC-NaTDC system showed a decrease in the conformational disorder and mobility of the acyl chains, a dehydratation of the interface, and changes in the orientation and H-bonding of DPPC polar head-groups. These effects were not observed with MLV, LUV and DPPC-Triton X100 micelles, thus indicating a specific recognition of DPPC in mixed phospholipid-bile salt micelles, in agreement with phospholipase activity measurements. Changes in the IR spectra during DPPC hydrolysis by GPLRP2 were monitored. Specific spectral features were associated to the production of lipolysis products and could be used for quantifying phospholipid lipolysis by FTIR
Wright, Lesley Catherine. "Lipids and cancer." Thesis, The University of Sydney, 1987. https://hdl.handle.net/2123/26014.
Full textZhang, Tejia. "Discovery of bioactive lipids and lipid pathways in cell death and disease." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11483.
Full textChemistry and Chemical Biology
Subramaniam, Varuni. "Preparation and Characterization of Novel Lipid and Proteolipid Membranes from Polymerizable Lipids." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/194889.
Full textYAMANE, Tsuneo. "Enzyme Engineering for Lipids." 名古屋大学農学国際教育協力研究センター, 2004. http://hdl.handle.net/2237/8930.
Full textShin, John J. H. "Lipids as pH biosensors." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45704.
Full textOldham, Alexis Jean. "Modulation of lipid domain formation in mixed model systems by proteins and peptides." View electronic thesis, 2008. http://dl.uncw.edu/etd/2008-1/r1/oldhama/alexisoldham.pdf.
Full textKamo, Tomoari. "Lipid membrane structure modulated by nonlamellar-forming lipids and interaction with amphipathic peptide." 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/137121.
Full textVlčková, Bohumila. "Testování komerčních přípravků do odlučovačů tuků." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2008. http://www.nusl.cz/ntk/nusl-216440.
Full textElbert, R., André Laschewsky, and H. Ringsdorf. "Hydrophilic spacer groups in polymerizable lipids: formation of biomembrane models from bulk polymerized lipids." Universität Potsdam, 1985. http://opus.kobv.de/ubp/volltexte/2009/1736/.
Full textSturgeon, Raymond M. "Interplay between cations, anionic lipids, and lipid-protein interactions at the nicotinic acetylcholine receptor." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28070.
Full textPrindiville, John S. "Circulating lipoproteins and tissue lipids: Effects of gemfibrozil on lipid metabolism in rainbow trout." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28555.
Full textSteer, Peter. "Lipids and Endothelium-Dependent Vasodilation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3424.
Full textDiekman, Mattheus Jozef Maria. "Thyroid hormones, lipids and endothelium." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/84351.
Full textSuen, Yu. "Microbial biosynthesis of neutral lipids." Diss., Georgia Institute of Technology, 1986. http://hdl.handle.net/1853/25197.
Full textMetwally, M. M. K. "Radiation induced peroxidation of lipids." Thesis, University of Salford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356180.
Full textZeng, Yi-dong B. "Geochemical studies of microbial lipids." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235488.
Full textKamath, Savita. "Characterization of residual whey lipids /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487935958848216.
Full textChilufya, Jedaidah Y., Shivakumar P. Devaiah, Richard R. Sante, and Aruna Kilaru. "Endocannabinoid-Like Lipids in Plants." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/4747.
Full textSPEZZANO, ROBERTO. "Lipids and Mass Spectrometry Application." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/647470.
Full textSantos, Lilia Zago Ferreira dos. "Suplementação com acido linoleico conjugado : influencia sobre a oxidação dos lipides biologicos e conteudo de lipides hepaticos de ratos Wistar saudaveis em crescimento." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/256175.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia de Alimentos
Made available in DSpace on 2018-08-09T10:09:33Z (GMT). No. of bitstreams: 1 Santos_LiliaZagoFerreirados_D.pdf: 3274551 bytes, checksum: 903add15d9aa93e05454196d09939604 (MD5) Previous issue date: 2007
Resumo: Ácido linoléico conjugado (CLA) é um conjunto de isômeros geométricos e posicionais do ácido linoléico, encontrado no leite, carnes e seus respectivos derivados. Desde a sua identificação como um agente anticarcinogênico, muitos outros efeitos lhe foram atribuídos; dentre eles, o efeito antioxidante, efeito um tanto quanto intrigante ao considerar que o CLA é um dieno conjugado, ou seja, um ácido graxo em sua fase inicial de autoxidação, mas com uma de suas ligas duplas conjugadas na forma trans. O objetivo desta Tese foi avaliar o efeito da suplementação com CLA, com e sem a presença de antioxidante, sobre o processo de autoxidação dos lípides biológicos, o conteúdo de lípides totais e a morfologia hepática de ratos Wistar saudáveis em crescimento. Foi realizado um ensaio biológico onde sessenta ratos foram divididos em seis grupos (n=10): grupos C (controle), CE (controle + vitamina E), AE (AdvantEdge® CLA), AEE (AdvantEdge® CLA + Vitamina E), CO (CLA One®) e COE (CLA One® + vitamina E). Os grupos controle C e CE receberam ácido linoléico e os grupos suplementados AE, AEE, CO e COE receberam misturas comerciais de CLA distintas cujo conteúdo médio de CLA era de 76,17 % com proporções semelhantes entre os isômeros trans-10, cis-12 e cis-9, trans-11. As condições de suplementação foram padronizadas em ensaio preliminar cujos resultados permitiram concluir que a melhor concentração de CLA a ser administrada, levando em consideração os aspectos operacionais e a resposta biológica, era de 2 % em relação ao consumo de dieta. Sendo assim, os ratos foram suplementados com 2 % de CLA por meio de entubação orogástrica durante 42 dias. Para os animais que receberam vitamina E em associação com o CLA, utilizou-se acetato de a-tocoferol na concentração de 30 mg / dia. Foram determinados índice de peróxido (IP), malondialdeído (MDA), 8-iso-PGF2a isoprostana e atividade da catalase como indicadores da autoxidação lipídica. O conteúdo total de lípides do fígado foi determinado e a morfologia do órgão foi analisada por meio de microscopia eletrônica de transmissão (MET). Os resultados demonstraram que a influência do CLA sobre o processo de oxidação dos lípides biológicos depende do tipo do suplemento e do indicador utilizado e seu respectivo local de determinação (tecido ou fluído corporal). Os valores de MDA sérico (AE: 1,80±0,67 mg MDA / kg; CO: 2,43±0,61 mg MDA / kg) e a atividade sérica da catalase (AE: 4734,23±1078,93 kU / L; CO: 5916,06±2490,71 kU / L) foram significativamente menores (P £ 0,05) em comparação com o controle (MDA: 3,85±0,24 mg MDA / kg; catalase: 10496,52±5121,84 kU / L), já os valores de 8-iso-PGF2a isoprostana foram maiores (P £ 0,05) para o grupo AE (urina: 95,13±20,26 pg / mL; plasma: 18,86±3,41 pg / mL) em relação ao controle (urina: 69,46±16,65 pg / mL; plasma: 13,84±3,55 pg / mL). Quanto ao IP, este foi maior (P £ 0,05) no grupo CO (84,38±10,97mEq / kg) em comparação com o grupo controle (54,75±9,70 mEq / kg). Em ralação à associação do acetato de a-tocoferol à suplementação com CLA, esta influenciou a ação do CLA sobre a oxidação dos lípides biológicos para os indicadores catalase, MDA hepático e 8-iso-PGF2a isoprostana urinária, de forma a diminuí-la. O conteúdo dos lípides hepáticos totais não aumentou nos ratos que receberam CLA (C: 23,93±3,64 %; AE: 21,19±2,05 %; CO: 21,16±0,90 %), embora as imagens obtidas por MET tenham demonstrado que houve aumento dos glóbulos de gordura em número e tamanho, aumento esse que não alterou a morfologia do órgão, visto que tanto o citoplasma quanto as organelas celulares estavam íntegras. Esses achados permitiram concluir que a suplementação com 2 % das misturas comerciais de CLA durante 42 dias influenciou o processo de oxidação dos lípides biológicos, no entanto, não foi possível estabelecer um consenso sobre seu efeito antioxidante/pró-oxidante visto a divergência dos resultados. Quanto às imagens hepáticas obtidas por MET, essas caracterizaram uma informação de natureza qualitativa, mas não menos importante, pois permitiu concluir que esse protocolo de suplementação com CLA não promeveu danos morfológicos ao órgão visto a integridade dos hepatócitos
Abstract: Conjugated linoleic acid (CLA) is a set of geometrical and positional isomers of the linoleic acid, found in milk, meats and their products. Since its identification as an anticarcinogenic agent, other effects have been attributed to it since, among them an antioxidant action -- a rather intriguing claim in view of the fact that CLA is a conjugated diene, i.e., a fatty acid in an early stage of autoxidation, but with one of its conjugated double bonds in the trans form. The objective of this Thesis was to assess the effect of CLA supplementation, both in the presence and in the absence of an antioxidant, on: (a) the process of biological lipid autoxidation, (b) the total lipid content, and (c) the hepatic morphology of healthy growing Wistar rats. A biological assay on sixty rats divided into six groups (n=10) was realized: C (control), CE (control + vitamin E), AE (AdvantEdge® CLA), AEE (AdvantEdge® CLA + Vitamin E), CO (CLA One®), and COE (CLA One®+ vitamin E). Control groups C and CE received linoleic acid, and supplemented groups AE, AEE, CO and COE received commercial CLA mixtures with a mean CLA content 76.17% and similar proportions of trans-10, cis-12 and cis-9, trans-11 isomers. A preliminary assay was conducted in order to standardize supplementation conditions; its results indicated that the best CLA concentration for administration, taking into account operational aspects and biological response, was 2% of diet intake. Rats were supplemented with that concentration of CLA by orogastric intubation for 42 days. For animals receiving vitamin E in combination with CLA, alpha-tocopherol acetate in the concentration of 30 mg/day was used. Peroxide index (IP), malondialdehyde (MDA), 8-iso-PGF2 alpha isoprostane, and catalase activity were determined as lipid autoxidation indicators. Total liver lipid content was determined, and organ morphology was examined by transmission electronic microscopy (TEM). Results demonstrated that the influence of CLA on the process of biological lipid oxidation depends on supplement type, on the chosen indicator, and on whether it is determined in a tissue or in a body fluid. Serum values of MDA (AE: 1.80±0.67 mg MDA / kg; CO: 2.43±0.61 mg MDA / kg) and catalase serum activity (AE: 4734.23±107893 kU / L; CO: 5916.06±2490.71 kU / L) were significantly lower (P <0,05) than in the controls (MDA: 3.85±0.24 mg MDA / kg; catalase: 10496.52±5121.84 kU / L), whereas 8-iso-PGF2 alpha isoprostane were higher (P <0.05) for AE (urina: 95.13±20.26 pg / mL; plasma: 18.86±3.41 pg / mL) than in the controls (urina: 69.46±16.65 pg / mL; plasma: 13.84±3.55 pg / mL). IP values were higher (P<0,05) for CO (84,.38±1097mEq / kg) than in the control (54.75±9.70 mEq / kg). Regarding the combination of alpha-tocopherol acetate and CLA supplementation, the presence of this antioxidant influenced the action of CLA on biological lipid oxidation as indicated by catalase, hepatic MDA and urinary 8-iso-PGF2 alpha isoprostane. Total hepatic lipid content did not increase in rats receiving CLA (C: 23.93±3,.64 %; AE: 21.19±2.05 %; CO: 21.16±0.90 %), although TEM images showed an increase in size and amount of fat globules; this, however, did not change organ morphology, as indicated by the fact that cell cytoplasm and organelles were undamaged. These findings allowed to conclude that supplementation with 2% of commercial CLA mixtures for 42 days influenced the process of biological lipid oxidation. However, no conclusion could be reached as to its anti-oxidant or prooxidant effect, because of inconsistencies in the results. Hepatic TEM images, even being a qualitative information, were nevertheless important, as they allowed to conclude that this CLA supplementation protocol did not cause any morphological damage to the organ, as indicated by the integrity of hepatocytes
Doutorado
Nutrição Experimental e Aplicada à Tecnologia de Alimentos
Doutor em Alimentos e Nutrição
Lehmal, Heidi. "Adaptation an niedrige Temperaturen: Lipide in Eisdiatomeen = Adaptation to low temperatures: lipids in ice diatoms /." Bremerhaven : Alfred-Wegener-Institut für Polar- und Meeresforschung, 1999. http://www.gbv.de/dms/bs/toc/302157891.pdf.
Full textFörster, Julia. "Genomweite Untersuchung einer sorbischen Kohorte zur Identifikation neuer mit dem Lipidstoffwechsel assoziierter Polymorphismen." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-102123.
Full textMusigamart, Natedao. "Study of the role of lipids from maturated coagula from Hevea brasiliensis latex on natural rubber behavior in oxidative conditions." Thesis, Montpellier, SupAgro, 2015. http://www.theses.fr/2015NSAM0004/document.
Full textNatural rubber (NR), a derived product from H. brasiliensis latex, is known for its high mechanical properties that are, for some, superior to those of its synthetic counterparts. However, the high degree of unsaturation of poly(cis-1,4-isoprene) makes it susceptible to thermo-oxidation. Fortunately, NR is endowed with non-isoprene components of which some have antioxidant properties. Especially, lipids, the main non-isoprene component retained in NR, have been reported to contain antioxidant substances, especially tocotrienols. It is well known that during the maturation of latex coagula, both NR physical properties and chemical composition are altered, but the complex mechanisms of this alteration are still to be elucidated. In the present work, the evolution of some native antioxidant molecules during maturation was followed in relation with some physical properties. Two experimental conditions of maturation were chosen. The first experiment involved uncontrolled conditions based on traditional unsmoked (USS) or ribbed smoked sheet (RSS) processing, while the second was performed in a dedicated maturation device with full control of environmental factors (relative humidity, temperature and oxygen content) followed by a processing based on that of Technically Specified Rubber (TSR). The evolution of samples during maturation was studied at different scales: bulk properties (P0, P30 and PRI), mesostructure (% gel content, Mw and Mn) and biochemical composition (lipids components). In parallel, in vitro antioxidant activity of NR lipid extracts was also investigated using an optimized DPPH method. Lipid quantity and quality evolved during maturation, especially under aerobic conditions. The total amount of lipid extract decreased, with a release of free fatty acids at early stage of maturation followed by a later decrease, unsaturated fatty acids being the first to disappear. The amount of extractable free γ-tocotrienol did not change much during maturation, while its esterified form was enriched in saturated fatty acids. The antioxidant activity measured in vitro correlated well with free γ-tocotrienol concentration but not with the resistance of rubber to thermo-oxidation assessed by P30 or PRI. Indeed, the in vitro conditions of measurement were far from those occurring inside rubber material. The localization of antioxidants in rubber and especially their physical possibility to interact with the double bonds of poly(cis-1,4-isoprene) or with oxidant species should be further investigated to understand what drives the drop of P30 along maturation time. Non extractable lipids or more polar non-isoprene molecular species (proteins, polyphenols, etc…) could also influence the resistance to thermo-oxidation
Berg, Anna-Lena. "Hepatic lipase methodological and clinical studies with special reference to its regulation by ACTH /." Lund : Depts. of Clinical Chemistry and nephrology, University of Lund, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39099405.html.
Full textWu, Yu. "Neuroprotective liquid crystalline cubosome and hexosome nanoparticle formulations by self-assembly of plasmalogen lipids and a neurotrophic peptide." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASQ003.
Full textThe primary aim of this thesis is to investigate the neuroprotective effect of plasmalogens (Pls) and explore the potential of lipid nanoparticles against neurodegenerative diseases. Our strategy aims to create a self-assembled system, enhancing the efficacy of plasmalogens and the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) for neuroprotection. The Pls, a distinctive group of membrane glycerophospholipids, typically contain a polyunsaturated fatty acyl chain at the sn-2 position and an alkyl chain linked by a vinyl-ether bond at the sn-1 position of the glycerol backbone. Pls, with their unique structure featuring a vinyl ether bond, possess free radical scavenging capabilities and antioxidant properties. Addressing the decline in plasmalogen levels in aging individuals holds promise for therapies related to Parkinson's disease, Alzheimer's disease, and dementia. Recent research has expanded our understanding of their antioxidant effects, anti-inflammation, and their involvement in ferroptosis. However, challenges persist in implementing plasmalogens in treatments of neurodegenerative diseases and in developing suitable drug delivery systems. We summarize the progress in lipid nanoparticles (LNPs) for targeting multiple neurodegeneration mechanisms. Our research on plasmalogen-loaded LNPs explores their fabrication mechanism and in vitro/in vivo impacts on neurodegenerative models. Our study shows the feasibility of enhancing Pls efficacy using LNPs as carriers. We employ natural plasmalogens from scallops to create nanoformulations involving a non-lamellar lipid excipient (MO) for structural stabilization, various surfactants, and small amounts of vitamin E, curcumin, or coenzyme Q10. Using small-angle X-ray scattering (SAXS), we identified the structural features of various LNPs (vesicles, cubosomes, and hexosomes). Our in vitro evaluations utilized human neuroblastoma SH-SY5Y cells, differentiated with 10 µM retinoic acid for 5 days. Cell viability tests indicated non-toxicity of the LNPs at a total lipid concentration of 10 µM for 24-hour incubation. We study the impact of Pls nanoparticles on an in vitro model of Parkinson's disease using neuronal cells induced by the neurotoxin 6-OHDA. Using the SH-SY5Y cell line, we explore cellular damage mechanisms (oxidative stress and apoptotic enzymes) via identifying the impact on the ERK-Akt-CREB-BDNF signaling pathway. Several documented neuroprotective compounds were used to demonstrate the ability to restore neuronal lesions caused by 6-OHDA, offering a model of neurodegenerative conditions to further elucidate the beneficial effects of the Pls-based LNPs. We then focus on the cAMP response element binding protein (CREB) and its phosphorylation leading to neurotrophin expression, crucial in preventing neurological disorders. Through lipid peptide nano-assemblies, we studied the impact of different structural organizations of the LNPs on CREB phosphorylation in an in vitro model of Parkinson's disease. Notably, liquid crystalline lipid nanoparticles loaded with plasmalogens prolonged CREB activation under neurodegenerative conditions, showing potential for enhanced neuroregeneration through sustained CREB activation in response to the neurotrophic nanoassemblies. In a mouse model of Parkinson's disease, vesicle and hexosome LNPs demonstrated distinct effectiveness in restoring motor function. The nanomedicine-mediated intervention influenced Parkinson's disease-related gene regulation and rebalanced lipid profiles. Nasal administration of Pls-loaded LNPs improved disease behavioral symptoms and downregulated genes like IL33 and Tnfa. The obtained results indicated the significant impact of hexosomal LNP nanomedicines on disease attenuation, lipid metabolism, and responsive gene modifications potentially involved in regeneration
Zhou, Albert Lihong. "Bioactivities of Milk Polar Lipids in Influencing Intestinal Barrier Integrity, Systemic Inflammation, and Lipid Metabolism." DigitalCommons@USU, 2013. http://digitalcommons.usu.edu/etd/1517.
Full textJeffery, Nicola. "Studies of the effects of dietary lipid manipulation upon blood lipids and immune cell function." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320212.
Full textHorn, Patrick J. "Development of Enabling Technologies to Visualize the Plant Lipidome." Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc499986/.
Full textDanial, John Shokri Hanna. "Imaging lipid phase separation on droplet interface bilayers." Thesis, University of Oxford, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711943.
Full textGomez, Rodrigo Enrique. "Unravelling the contribution of lipids in plant autophagy : Identification and functional characterization of lipids implicated in the autophagic process in Arabidopsis." Thesis, Bordeaux, 2021. http://www.theses.fr/2021BORD0103.
Full textPlants, being sessile organisms, are frequently confronted to a plethora of environmental stresses and harsh conditions. Enduring these conditions can lead to the accumulation of protein aggregates or organelles that become dysfunctional. To withstand these conditions, plants have evolved sophisticated adaptation mechanisms for the recycling of intracellular components. These mechanisms are essential for the metabolic transitions required for efficient nutrient use, as well as proper disposal of protein aggregates or damaged organelles. One of these mechanisms is autophagy, an intracellular degradation pathway that employs specialized double membrane vesicles that encapsulate cytosolic material and delivers it to the vacuole for degradation. Autophagy relies on the formation of these specialized vesicles, called autophagosomes (APs). APs are unique vesicles in the endomembrane system, first because they are made of a double lipid bilayer, and second because they do not but from a pre-existing compartment. AP biogenesis is a multistep process implicating a core machinery (ATG proteins) that mediate the de novo formation of an initial membrane; then, by the addition of lipids, this membrane expands into a cup-shaped structure with highly curved edges to engulf autophagic cargo. Upon completion, the rims of the structure seal and form a mature AP that traffics to the vacuole, where its outer membrane fuses with the tonoplast releasingthe inner membrane and cargo inside the vacuole. Thus, AP biogenesis relies on numerous membrane remodeling events, first to initiate the initial membrane, then to maintain the highly curved shape of the structure while ensuring its expansion, and finally to seal the mature structures and its subsequent fusion to the vacuole. Lipids, thanks to their physicochemical properties define important membrane features such as its, fluidity, curvature and electrostatics. Hence, evidence showing the crucial role of lipids in autophagy has emerged in the recent years. In plants however, little is known about the lipid composition of autophagic membranes and thus, about the functional contribution of lipids in plant autophagy. My PhD thesis consisted on identifying crucial lipids for plant autophagy with an aim to characterize their function in the process. By performing a lipid-related enzymes inhibitor screen in which we assayed the impact of inhibiting the synthesis of specific lipids on autophagy, we identified different lipid candidates important for plant autophagy. Notably, we identified the phosphatydil-inositol-4-phosphate (PI4P) as being critical for the formation of APs. In the absence of PI4P, AP formation is stalled at a very early stage resulting in a block in the process. Furthermore, we have obtained valuable insights to better understand the AP formation. In plants, particularly, our results suggest that the plasma membrane (PM) plays important roles in the formation of these structures. Taken together, our results confirmed that lipids are more than just building blocks constituting the autophagic membranes; rather, they seem to play distinct and specific roles in the pathway. Finally, this thesis highlights how lipids are key actors for the autophagic process and thus for plants adaptations to adverse and stressful environmental conditions
Kaur, Gurpreet. "Microbial membrane lipids in geothermal environments." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503942.
Full textSharma, Monika. "ROLE OF LIPIDS IN TOMBUSVIRUS REPLICATION." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/845.
Full textMinabe, Masaharu. "The lipids of post-fermentation yeast." Thesis, Heriot-Watt University, 1992. http://hdl.handle.net/10399/1487.
Full textAdhamy, Asghar. "Selective hydrolysis of lipids using lipases." Thesis, Teesside University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328090.
Full textAnderson, Richard Anthony. "Lipids, oxidative stress and endothelial function." Thesis, King's College London (University of London), 2004. https://kclpure.kcl.ac.uk/portal/en/theses/lipids-oxidative-stress-and-endothelial-function(ca261d48-d716-4156-9a38-dbb72775b36a).html.
Full textThomas, Alyson. "Thermal adaptation of bacterial membrane lipids." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277109.
Full textBarbary, O. M. "Effects of ionizing radiation on lipids." Thesis, University of Salford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372135.
Full textWan, Jung Wing. "Novel ether lipids as antineoplastic agents." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242627.
Full textTymkewycz, Paulina M. "Biologically active lipids and platelet function." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/30866.
Full textAnthony, Renil J. "Solvent Extraction of Lipids from Microalgae." Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1280854965.
Full textGonçalves, José Manuel Carita. "Photosensitizer effect in Aeromonas salmonicida lipids." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13334.
Full textPhotodynamic inactivation is a simple and effective method to destroy microorganism. PDI combines the use of light with a photosensitizer, as porphyrins, which in the presence of oxygen, leads to the formation of reactive oxygen species, such as singlet oxygen and free radicals, capable to oxidize vital membrane structures. The key advantages of Photodynamic Therapy (PDI) are the efficacy in bacteria, fungi, yeasts and protozoa; the low level of resistance induction; and the use of a cheap light source. It is fundamental to understand the importance of cell targets to better understand the photooxidation process. Lipids are important membrane components in bacteria. The main goal of this study was to evaluate the charge effect of four porphyrin derivatives used as photosensitizers in PDI in the photo-oxidation of membrane lipids of Aeromonas salmonicida and relate with the inactivation of this bacterium. The goal was achieved by quantification of lipid hydroperoxides by FOX II method, fatty acid profiles analysis by GC-FID and viability assays; in different periods of light exposure. After PDI it was observed formation of lipid hydroperoxides, changes in the fatty acids profile and a decrease on cell survival. However the results are dependent on the porphyrin used. According to these results, the photooxidation is not directly proportional with the number of charges in the photosensitizers, as other studies had been reported. A direct relation between the photo-oxidation of membrane lipids with the photo-inactivation in the studied bacterium was observed and an order of effectiveness was established. This study reinforces that cationic porphyrins are effective to inactivate bacteria and the importance and efficiency of photodynamic inactivation, as a viable alternative to traditional procedures.
A Inactivação fotodinâmica é um método simples e eficiente na inactivação de microorganismos. Inactivação fotodinâmica combina o uso de luz com um fotosensibilizador, como por exemplo porfirinas, que na presença de oxigénio gera a formação de espécies reactivas de oxigénio, como o oxigénio singleto e radicais livres, que são capazes de oxidar componentes membranares vitais. As principais vantagens da Terapia Fotodinâmica (TFD) são a sua eficiência na inactivação de bactérias, fungos, leveduras e protozoários; o baixo nível de indução de resistência; e o uso de fontes de luz baratas. Para melhor compreender esta técnica, é fundamental compreender o seu mecanismo de acções em alvos celulares. Os lípidos são importantes componentes nas membranas bacterianas, que muito recentemente foram reconhecidos como um dos alvos da PDI, e que podem estar envolvidos no processo de inactivação bacteriana. O principal objectivo deste estudo foi avaliar o efeito de quatro derivados porfirínicos utilizados com fotosensibilizadores em PDI, na foto-oxidação de lípidos membranares em Aeromonas salmonicida, e relacionar este efeito com a inactivação desta bactéria. Para tal foram realizados testes para a avaliação da peroxidação lipídica, através da quantificação de hidroperóxidos lípidos por FOX II e pela análise da variação do perfil de ácidos gordos por GC-FID em diferentes tempos de exposição à luz. Os resultados obtidos foram correlacionados ensaios de viabilidade celular; Após PDI foi observada a formação de hidroperóxidos lipídico, alterações no perfil de ácidos gordos e diminuição da sobrevivência celular. No entanto estes resultados estão dependentes na escolha da porfirina, tal como outros estudos demonstram. Foi possível estabelecer uma relação directa entre a fotooxidação dos lípidos membranares com a foto-inactivação da bactéria em estudo e estabelecer uma ordem de eficiência para as quatro porfirinas. Este estudo vem reforçar que as porfirinas catiónicas são eficientes na inactivação de bactérias e que a inactivação fotodinâmica é importante e eficiente, sendo uma técnica viável alternativa a metodologias tradicionais.
Moran, Josephine. "Staphylococcal responses to antimicrobial skin lipids." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2007282/.
Full textEvans, D. A. "Molecular dynamics simulations of skin lipids." Thesis, University of Bath, 1996. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296332.
Full textLiaščukienė, Irma. "Lipidų sluoksniai ant nanostruktūrizuoto aliuminio: formavimosi mechanizmas, stabilumas ir įtaka paviršiaus savybėms." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140722_081312-46485.
Full textThe self-assembly of fatty acids (FA) on the surfaces of inorganic materials is a relevant way to control their wetting properties. While the mechanism of adsorption on model flat substrate is well described in the literature, interfacial processes remain poorly documented on nanostructured surfaces. Investigation of the mechanism of self-assembly of fatty acids (FA) and methyl oleate on an Al oxy-hydroxide surface was done. After the FA adsorption, the presence of coordinative bonded carboxylate species on the Al oxy-hydroxide surface is demonstrated by means of PM-IRRAS analysis. The contact of methyl oleate with the surface leads to its chemical transformation through a saponification-hydrolysis reaction. As a consequence, it binds to the surface in a manner similar to that for fatty acids. AFM demonstrated the change of morphology - the existence of highly ordered nanostructures, the formation of aligned nano-patterns, guided only by the FA self-assembly. The stability and the origin of wetting properties of the self-assembled layers was examined under UV/O3 treatment, in air and in aqueous media taking into account key parameters, namely the surface roughness and its composition. Results revealed that no correlation can be made between water contact angles and the Wenzel roughness. By contrast, water contact angle strongly increased with the amount of -CHx- groups exhibited by adsorbed FA. These findings suggest that the main origin of hydrophobisation is the presence... [to full text]
Hammam, Hagar. "Lipids in supercritical carbon dioxide physical functional aspects /." Lund : Dept. of Food Technology, University of Lund, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39158186.html.
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