Academic literature on the topic 'Lipidome profile'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Lipidome profile.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "Lipidome profile"
1
Koh, Jung Hee, Sang Jun Yoon, Mina Kim, Seonghun Cho, Johan Lim, Youngjae Park, Hyun-Sook Kim, Sung Won Kwon, and Wan-Uk Kim. "Lipidome profile predictive of disease evolution and activity in rheumatoid arthritis." Experimental & Molecular Medicine 54, no. 2 (February 2022): 143–55. http://dx.doi.org/10.1038/s12276-022-00725-z.
Full textAbstract:
AbstractLipid mediators are crucial for the pathogenesis of rheumatoid arthritis (RA); however, global analyses have not been undertaken to systematically define the lipidome underlying the dynamics of disease evolution, activation, and resolution. Here, we performed untargeted lipidomics analysis of synovial fluid and serum from RA patients at different disease activities and clinical phases (preclinical phase to active phase to sustained remission). We found that the lipidome profile in RA joint fluid was severely perturbed and that this correlated with the extent of inflammation and severity of synovitis on ultrasonography. The serum lipidome profile of active RA, albeit less prominent than the synovial lipidome, was also distinguishable from that of RA in the sustained remission phase and from that of noninflammatory osteoarthritis. Of note, the serum lipidome profile at the preclinical phase of RA closely mimicked that of active RA. Specifically, alterations in a set of lysophosphatidylcholine, phosphatidylcholine, ether-linked phosphatidylethanolamine, and sphingomyelin subclasses correlated with RA activity, reflecting treatment responses to anti-rheumatic drugs when monitored serially. Collectively, these results suggest that analysis of lipidome profiles is useful for identifying biomarker candidates that predict the evolution of preclinical to definitive RA and could facilitate the assessment of disease activity and treatment outcomes.
2
Wallace, Martina, Ciara Morris, Colm M. O'Grada, Miriam Ryan, Eugene T. Dillon, Eilish Coleman, Eileen R. Gibney, Michael J. Gibney, Helen M. Roche, and Lorraine Brennan. "Relationship between the lipidome, inflammatory markers and insulin resistance." Mol. BioSyst. 10, no. 6 (2014): 1586–95. http://dx.doi.org/10.1039/c3mb70529c.
Full textAbstract:
The objectives of the present study were to (1) examine the effects of the phenotypic factors age, gender and BMI on the lipidomic profile and (2) investigate the relationship between the lipidome, inflammatory markers and insulin resistance.
3
Dahdah, Norma, Alba Gonzalez-Franquesa, Sara Samino, Pau Gama-Perez, Laura Herrero, José Carlos Perales, Oscar Yanes, Maria Del Mar Malagón, and Pablo Miguel Garcia-Roves. "Effects of Lifestyle Intervention in Tissue-Specific Lipidomic Profile of Formerly Obese Mice." International Journal of Molecular Sciences 22, no. 7 (April 1, 2021): 3694. http://dx.doi.org/10.3390/ijms22073694.
Full textAbstract:
Lipids are highly diverse in their composition, properties and distribution in different biological entities. We aim to establish the lipidomes of several insulin-sensitive tissues and to test their plasticity when divergent feeding regimens and lifestyles are imposed. Here, we report a proton nuclear magnetic resonance (1H-NMR) study of lipid abundance across 4 tissues of C57Bl6J male mice that includes the changes in the lipid profile after every lifestyle intervention. Every tissue analysed presented a specific lipid profile irrespective of interventions. Glycerolipids and fatty acids were most abundant in epididymal white adipose tissue (eWAT) followed by liver, whereas sterol lipids and phosphoglycerolipids were highly enriched in hypothalamus, and gastrocnemius had the lowest content in all lipid species compared to the other tissues. Both when subjected to a high-fat diet (HFD) and after a subsequent lifestyle intervention (INT), the lipidome of hypothalamus showed no changes. Gastrocnemius and liver revealed a pattern of increase in content in many lipid species after HFD followed by a regression to basal levels after INT, while eWAT lipidome was affected mainly by the fat composition of the administered diets and not their caloric density. Thus, the present study demonstrates a unique lipidome for each tissue modulated by caloric intake and dietary composition.
4
Sikorskaya, Tatyana V., Ekaterina V. Ermolenko, Kseniya V. Efimova, and Ly T. P. Dang. "Coral Holobionts Possess Distinct Lipid Profiles That May Be Shaped by Symbiodiniaceae Taxonomy." Marine Drugs 20, no. 8 (July 28, 2022): 485. http://dx.doi.org/10.3390/md20080485.
Full textAbstract:
Symbiotic relationships are very important for corals. Abiotic stressors cause the acclimatization of cell membranes in symbionts, which possess different membrane acclimatization strategies. Membrane stability is determined by a unique lipid composition and, thus, the profile of thylakoid lipids can depend on coral symbiont species. We have analyzed and compared thylakoid lipidomes (mono- and digalactosyldiacylglycerols (MGDG and DGDG), sulfoquinovosyldiacylglycerols (SQDG), and phosphatidylglycerols (PG)) of crude extracts from symbiotic reef-building coral Acropora sp., the hydrocoral Millepora platyphylla, and the octocoral Sinularia flexibilis. S. flexibilis crude extracts were characterized by a very high SQDG/PG ratio, a DGDG/MGDG ratio < 1, a lower degree of galactolipid unsaturation, a higher content of SQDG with polyunsaturated fatty acids, and a thinner thylakoid membrane which may be explained by the presence of thermosensitive dinoflagellates Cladocopium C3. In contrast, crude extracts of M. platyphylla and Acropora sp. exhibited the lipidome features of thermotolerant Symbiodiniaceae. M. platyphylla and Acropora sp. colonies contained Cladocopium C3u and Cladocopium C71/C71a symbionts, respectively, and their lipidome profiles showed features that indicate thermotolerance. We suggest that an association with symbionts that exhibit the thermotolerant thylakoid lipidome features, combined with a high Symbiodiniaceae diversity, may facilitate further acclimatization/adaptation of M. platyphylla and Acropora sp. holobionts in the South China Sea.
5
Guerra, Inês M. S., Helena B. Ferreira, Tânia Melo, Hugo Rocha, Sónia Moreira, Luísa Diogo, Maria Rosário Domingues, and Ana S. P. Moreira. "Mitochondrial Fatty Acid β-Oxidation Disorders: From Disease to Lipidomic Studies—A Critical Review." International Journal of Molecular Sciences 23, no. 22 (November 11, 2022): 13933. http://dx.doi.org/10.3390/ijms232213933.
Full textAbstract:
Fatty acid oxidation disorders (FAODs) are inborn errors of metabolism (IEMs) caused by defects in the fatty acid (FA) mitochondrial β-oxidation. The most common FAODs are characterized by the accumulation of medium-chain FAs and long-chain (3-hydroxy) FAs (and their carnitine derivatives), respectively. These deregulations are associated with lipotoxicity which affects several organs and potentially leads to life-threatening complications and comorbidities. Changes in the lipidome have been associated with several diseases, including some IEMs. In FAODs, the alteration of acylcarnitines (CARs) and FA profiles have been reported in patients and animal models, but changes in polar and neutral lipid profile are still scarcely studied. In this review, we present the main findings on FA and CAR profile changes associated with FAOD pathogenesis, their correlation with oxidative damage, and the consequent disturbance of mitochondrial homeostasis. Moreover, alterations in polar and neutral lipid classes and lipid species identified so far and their possible role in FAODs are discussed. We highlight the need of mass-spectrometry-based lipidomic studies to understand (epi)lipidome remodelling in FAODs, thus allowing to elucidate the pathophysiology and the identification of possible biomarkers for disease prognosis and an evaluation of therapeutic efficacy.
6
Lamichhane, Santosh, Linda Ahonen, Thomas Sparholt Dyrlund, Alex M. Dickens, Heli Siljander, Heikki Hyöty, Jorma Ilonen, et al. "Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes." Biomolecules 9, no. 1 (January 21, 2019): 33. http://dx.doi.org/10.3390/biom9010033.
Full textAbstract:
Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR.
7
Heintz, Melissa M., Ramiya Kumar, Kristal M. Maner-Smith, Eric A. Ortlund, and William S. Baldwin. "Age- and Diet-Dependent Changes in Hepatic Lipidomic Profiles of Phospholipids in Male Mice: Age Acceleration in Cyp2b-Null Mice." Journal of Lipids 2022 (March 29, 2022): 1–17. http://dx.doi.org/10.1155/2022/7122738.
Full textAbstract:
Increases in traditional serum lipid profiles are associated with obesity, cancer, and cardiovascular disease. Recent lipidomic analysis has indicated changes in serum lipidome profiles, especially in regard to specific phosphatidylcholines, associated with obesity. However, little work has evaluated murine hepatic liver lipidomic profiles nor compared these profiles across age, high-fat diet, or specific genotypes, in this case the lack of hepatic Cyp2b enzymes. In this study, the effects of age (9 months old), high-fat diet (4.5 months old), and the loss of three primarily hepatic xeno- and endobiotic metabolizing cytochrome P450 (Cyp) enzymes, Cyp2b9, Cyp2b10, and Cyp2b13 (Cyp2b-null mice), on the male murine hepatic lipidome were compared. Hierarchical clustering and principal component analysis show that age perturbs hepatic phospholipid profiles and serum lipid markers the most compared to young mice, followed by a high-fat diet and then loss of Cyp2b. Several lipid biomarkers such as PC/PE ratios, PE 38 : 6, and LPC concentrations indicate greater potential for NAFLD and hypertension with mixed effects in Cyp2b-null mice(less NAFLD and greater hypertension-associated markers). Lipid profiles from older mice contain greater total and n-6 fatty acids than normal diet (ND)-fed young mice; however, surprisingly, young Cyp2b-null mice contain high n-6 : n-3 ratios. Overall, the lack of Cyp2b typically enhanced adverse physiological parameters observed in the older (9 mo) mice with increased weight gain combined with a deteriorating cholesterol profile, but not necessarily all phospholipid profiles were adversely perturbed.
8
Jové, Mariona, Natàlia Mota-Martorell, Irene Pradas, José Daniel Galo-Licona, Meritxell Martín-Gari, Èlia Obis, Joaquim Sol, and Reinald Pamplona. "The Lipidome Fingerprint of Longevity." Molecules 25, no. 18 (September 22, 2020): 4343. http://dx.doi.org/10.3390/molecules25184343.
Full textAbstract:
Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species—humans included—demonstrate that both the cell membrane fatty acid profile and lipidome are a species-specific optimized evolutionary adaptation and traits associated with longevity. All these emerging observations point to lipids as a key target to study the molecular mechanisms underlying differences in longevity and suggest the existence of a lipidome profile of long life.
9
da Costa, Elisabete, Fernando Ricardo, Tânia Melo, Renato Mamede, Maria H. Abreu, Pedro Domingues, M. Rosário Domingues, and Ricardo Calado. "Site-Specific Lipidomic Signatures of Sea Lettuce (Ulva spp., Chlorophyta) Hold the Potential to Trace Their Geographic Origin." Biomolecules 10, no. 3 (March 23, 2020): 489. http://dx.doi.org/10.3390/biom10030489.
Full textAbstract:
The wild harvest and aquaculture of Ulva spp. has deserved growing attention in Europe. However, the impact of geographical origin on the biochemical composition of different species and/or strains is yet to be described in detail. Hence, the present study aimed to detect the variability of the lipidome of different species and/or strains of Ulva originating from different geographic locations. We hypothesized that lipidomic signatures can be used to trace the geographic origin post-harvesting of these valuable green seaweeds. Ulva spp. was sampled from eight distinct ecosystems along the Atlantic Iberian coast and Ulva rigida was sourced from an aquaculture farm operating a land-based integrated production site. Results showed significant differences in the lipidomic profile displayed by Ulva spp. originating from different locations, namely, due to different levels of polyunsaturated betaine lipids and galactolipids; saturated betaine lipids and sulfolipids; and some phospholipid species. Overall, a set of 25 site-specific molecular lipid species provide a unique lipidomic signature for authentication and geographic origin certification of Ulva species. Present findings highlight the potential of lipidome plasticity as a proxy to fight fraudulent practices, but also to ensure quality control and prospect biomass for target bioactive compounds.
10
Horvath, Lisa, Hui-Ming Lin, Kate Lynette Mahon, Jacquelyn Weir, Piyushkumar Mundra, Calan Spielman, Karen P. Briscoe, et al. "The plasma lipidome in castration-resistant prostate cancer." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 5055. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.5055.
Full textAbstract:
5055 Background: Biomarker studies of metastatic castration-resistant prostate cancer (CRPC) have mainly focused on changes in the cancer, however, the host environment and its interactions with cancer is increasingly important, especially given the increasing association of PC outcomes and obesity. We sought associations between the plasma lipidome and clinical outcome in CRPC. Methods: Plasma samples were obtained from a Phase 1 discovery cohort of 96 CRPC patients before and after the first cycle of docetaxel chemotherapy. Lipidomic profiling of the plasma samples was performed by liquid chromatography and electrospray ionisation-tandem mass spectrometry. Results were subsequently assessed in a Phase 2 validation cohort of 63 CRPC patients. Results: Lipidomic profiling detected 323 lipid species in plasma samples from the Phase 1 cohort. Patients could be classified into two subgroups with significant survival differences according to their baseline lipidomic profiles (median overall survival 13.7 vs 21.7 months; HR 2.31, 95% CI 1.44-3.68, p = 0.0005). The baseline levels of 46 lipids were individually prognostic (p < 0.01) and predominantly sphingolipids. A prognostic three-lipid signature was derived (ceramide (d18:1/24:1), sphingomyelin (d18:2/16:0), phosphatidylcholine (16:0/16:0)) (11.7 versus 21.7 months, p = 0.00001; HR 2.94, 95% CI 1.80-4.81, p = 0.00002). The signature was associated with shorter overall survival in the Phase 2 cohort (HR 4.78, 95% CI 2.06-11.1, p = 0.0003), and was an independent prognostic factor when modeled with clinicopathological factors and metabolic characteristics (BMI, cholesterol and triacylglycerol). The AUC of ROC analysis of 12 month survival for a clinicopathological model (AUC 0.70, 95% CI 0.54-0.87, p = 0.03) was enhanced by the addition of the 3-lipid signature (AUC 0.73, 95% CI 0.57-0.89, p = 0.01). Conclusions: Our study is the first to comprehensively profile the plasma lipidome of men with CRPC using cutting-edge lipidomic profiling technology, to identify a plasma lipid signature that can reproducibly predict outcome in CRPC and can improve on clinicopathological models. Therapeutic modulation of the levels of these lipids by targeting their metabolic pathways may improve patient outcome.
Dissertations / Theses on the topic "Lipidome profile"
1
LOREGGIAN, LARA. "MEDITERRANEAN DIET RESHAPES PERIPHERAL SECRETOME AND LIPIDOME PROFILES IN PATIENTS WITH METABOLIC SYNDROME." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/783295.
Full textAbstract:
La perdita di peso nei pazienti con sindrome metabolica ha effetti positivi sulle malattie cardiovascolari e sul rischio di diabete di tipo 2, ma i suoi effetti sul profilo lipidico e sul secretoma periferico sono tutt’ora poco chiari. Al fine di determinare gli effetti della perdita di peso indotta dalla dieta sui parametri metabolici sono stati analizzati il profilo lipidico e il secretoma periferico in pazienti affetti da sindrome metabolica.
In questo studio sono stati arruolati 18 soggetti adulti di sesso maschile con sindrome metabolica e BMI compreso tra 25 e 35 Kg/m2, che sono stati sottoposti a dieta Mediterranea ipocalorica bilanciata per 6 mesi. Lo scopo dell'approccio dietetico era quello di indurre nei pazienti una perdita di peso di almeno il 5% del peso corporeo iniziale.
Dopo la perdita di peso abbiamo osservato un miglioramento significativo del BMI, dei livelli di insulina, della glicemia a digiuno, dell’indice HOMA-I, dei livelli di trigliceridi, di LDL e HDL. L'analisi delle lipoproteine circolanti ha mostrato un cambiamento significativo nella loro composizione. In particolare, abbiamo osservato un trasferimento importante di triacilgliceroli dalle HDL alle LDL. A tale cambiamento si è associata una significativa riduzione delle citochine proinfiammatorie periferiche, come IL-6, TNF-α, IL-8 e MIP-1β. Abbiamo inoltre osservato un'interessante correlazione positiva tra i livelli di citochine e livelli periferici di CETP (cholesteryl ester transfer protein), un enzima con un ruolo chiave nel trasferimento di esteri del colesterolo tra le lipoproteine.
La perdita di peso ottenuta attraverso la dieta Mediterranea ipocalorica ha determinato un miglioramento del profilo lipidico periferico, un cambiamento nella composizione delle lipoproteine e del secretoma.
Questi risultati sono fondamentali per comprendere i benefici della perdita di peso e i meccanismi che possono avere un ruolo nel miglioramento del rischio cardiovascolare.Weight loss in patients with metabolic syndrome has positive effects on cardiovascular diseases and type 2 diabetes risk, but its effects on peripheral secretome and lipidome profiles are still poorly understood. In order to determine the effects of diet-induced weight loss on metabolic parameters, lipidome and secretome profiles were evaluated. In this study, 18 adult males with metabolic syndrome and BMI between 25 and 35 Kg/m2 were enrolled, and then subjected to a balanced hypocaloric Mediterranean diet for 6 months. The aim of the dietetic approach was to induce in patients a weight loss of at least 5% of the initial body weight. After weight loss, we observed a significant improvement in BMI, insulin, fasting blood glucose, HOMA-I, triglyceridemia, LDL, and HDL levels. The analysis of circulating lipoproteins showed a significant change in their composition. In particular, a massive transfer of triacylglycerols from HDL to LDL was observed. This result was associated with a significant reduction in peripheral pro-inflammatory cytokines, such as IL-6, TNF-α, IL-8, and MIP-1β. We also observed an interesting positive correlation among cytokines levels and peripheral levels of CETP (cholesteryl ester transfer protein), an enzyme with a key role in lipid metabolism. The results achieved suggest that weight loss obtained through the hypocaloric Mediterranean diet is associated with an improvement in peripheral lipidome and secretome profiles. Furthermore, this dietetic approach stimulated changes in lipoproteins composition. These results are fundamental to understand weight loss benefits and the mechanisms that may play a role in improving cardiovascular risk.
2
Durn, Joanne H., Kay M. Marshall, D. Farrar, Peter J. O'Donovan, Andy J. Scally, D. F. Woodward, and Anna Nicolaou. "Lipidomic analysis reveals prostanoid profiles in human term pregnant myometrium." Elsevier, 2010. http://hdl.handle.net/10454/4585.
Full textAbstract:
noProstanoids modulate the activity of human pregnant myometrium and their functional role can be appreciated through characterisation of prostanoid receptors and tissue concentration of prostanoids. We have applied a lipidomic approach to elucidate the profile of prostanoids in human non-labouring and labouring myometrium. We have identified a total of nineteen prostanoids including prostacyclin, thromboxanes, prostaglandins and dihydro-prostaglandins. Prostacyclin was the predominant prostanoid in both non-labouring and labouring myometria, with PGD2 and PGF2¿ being the second most abundant. Although the total amount of prostanoids was increased in the labouring tissue, PGE2 and 13,14-dihydro-15-keto-PGE2 were the only prostanoids to increase significantly at early and late labour (p¿0.001). Our data suggest that PGF2¿ plays an important role in parturition, whilst the increase in PGE2 could occur to facilitate cervical dilation and relaxation of the lower myometrium during labour. Although the elevation in TXA2 was less marked than expected, in terms of translation to function even a relatively small increase in the level of this potent spasmogen may have significant effects.
3
Zdanyte, Monika [Verfasser]. "Lipidomic Profile of Platelets as a Peripheral Biomarker in Patients with Coronary Artery Disease / Monika Zdanyte." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1227964757/34.
Full text
4
Azevedo, Vítor Manuel Madureira. "Lipidomic study of the red marine macroalgae as source of bioactive compounds." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17513.
Full textAbstract:
Mestrado em Mestre em Bioquímica, ramo da Bioquímica ClínicaMarine macroalgae, or seaweeds, have gained an increased interest in recent times for the use in various biotechnological applications, due to the added-value of their chemical constituents. Among them, glycolipids and phospholipids display several commercial applications in a wide spectrum of industries, such as food, pharmaceutical and cosmetic. In an effort to further understand the lipid composition of macroalgae, the present work reports, for the first time, the isolation and characterization of the polar lipid profile of the red macroalgae Porphyra dioica cultivated on a land-based integrated multi-trophic aquaculture (IMTA) system, using a lipidomic-based approach employing hydrophilic interaction liquid chromatography-eletrospray ionization mass spectrometry (HILIC-ESI-MS). The fatty acid profile of this species of seaweed was also determined, accounting for season variability and its life cycle. The polar lipid profile of P. dioica revealed the presence of over 69 molecular species, corresponding to glycolipids (sulfoquinovolsyldiacylglycerols, sulfoquinovosylmonoacylglycerols, digalactosyldiacylglycerols) and glycerophospholipids (lyso- and phosphatidylglycerols), lyso- and phosphatidylcholines), as well as phytyl derivatives. Some of these polar lipids contain polyunsaturated fatty acids (PUFAs), namely arachidonic acid (C20:4) and eicosapentaenoic acid (C20:5), thus revealing the ability of P. dioica to biosynthesize this long chain PUFAs. P.dioica from the winter season revealed to be richer in PUFA content, accounting for 37.0% of total fatty acid (TFA) content, as opposed to P. dioica from the summer season (25.0% of TFA content). Eicosapentaenoic acid (EPA) content was revealed to be being significantly higher in the winter season (25.2% of TFA content). The diploid sporophyte conchocelis phase of P. dioica showed to possess the highest amount of PUFAs (47.0% of TFA content), with arachidonic acid being the most abundant fatty acid (21.2% of TFA content). Several of the lipids identified have been reported to possess nutritional and health benefits, thus allowing the valorisation of P. dioica from IMTA as a source of bioactive compounds, adequate for the use in a wide range of different applications and as a functional food, rich in omega-3 fatty acids.
As macroalgas têm vindo a ganhar um interesse cada vez maior para o uso em diversas aplicações biotecnológicas, devido ao valor acrescentado dos seus diferentes constituintes. Entre estes, os glicolípidos e os fosfolípidos podem ser usados comercialmente em diferentes indústrias, tais como as indústrias alimentar, farmacêutica e cosmética. Com o objetivo de compreender melhor a composição lipídica das macroalgas, o presente trabalho relata, pela primeira vez, a caracterização do perfil de lípidos polares da macroalga vermelha Porphyra dioica, cultivada num sistema de aquacultura multi-trófica integrada (IMTA), utilizando para esse fim uma abordagem lipidómica baseada na espectrometria de massa (HILIC-ESI-MS). Foi também determinado o perfil de ácidos gordos da referida espécie de alga, tendo em consideração a variabilidade sazonal e o seu ciclo de vida. O perfil de lípidos polares da alga P. dioica revelou a presença de mais de 69 espécies moleculares diferentes, correspondendo a classes de glicolípidos (sulfoquinovosildiacilgliceróis, sulfoquinovosilmonoacilgliceróis e digalactosildiacilgliceróis), fosfolípidos (liso- e fosfatidilglicerol, liso- e fosfatidilcolinas) e derivados fitil. Alguns destes lípidos polares contêm ácidos gordos polinsaturados (PUFAs) na sua composição, nomeadamente o ácido araquidónico (C20:4) e ácido eicosapentaenóico (C20:5), revelando, assim, a capacidade da alga P. dioica em biossintetizar este tipo de ácidos gordos polinsaturados de cadeia longa. Considerando a variação sazonal do conteúdo em ácidos gordos, a P. dioica cultivada no inverno revelou ser mais rica em PUFAs, correspondendo a 37.0% do conteúdo total de ácidos gordos, contrariamente à P. dioica cultivada no verão (25.0%). O conteúdo em ácido eicosapentaenóico (EPA) é significativamente maior na estação de inverno (25.2%). O perfil em ácidos gordos também variou com o ciclo de vida P. dioica, sendo que na fase de conchocelis a quantidade de PUFA é significativamente mais elevada (47.0% de conteúdo de ácidos gordos), sendo o ácido araquidónico o ácido gordo mais abundante (21.2% de conteúdo de ácidos gordos).Várias classes de lípidos polares foram identificados como possuindo benefícios nutricionais e para a saúde, permitindo assim a valorização da alga vermelha P. dioica produzida em IMTA como uma fonte de compostos bioativos, adequados para o uso numa grande variedade de aplicações como um alimento funcional, rica em ácidos gordos polinsaturados ómega-3.
5
Eggers, Lars Florian [Verfasser]. "Systematic investigation of lipid profiles from human lung tissues reveals specific lipidome alterations in lung cancer and pulmonary emphysema / Lars Florian Eggers." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2018. http://d-nb.info/1156308992/34.
Full text
6
Du, Qin. "Optimisation des profils lipidiques du cerveau de rats déficients en oméga-3 au sevrage par l'utilisation de matière grasse laitière : conséquences au niveau du lipidome." Thesis, Aix-Marseille 2, 2010. http://www.theses.fr/2010AIX20717/document.
Full textAbstract:
L‟acide docosahexaénoïque (DHA) s‟accumule principalement dans les membranes cérébrales humaines durant la période périnatale et les 2 premières années de la vie. Optimiser l‟incorporation des acides gras polyinsaturés à longue chaîne (AGPI-LC) n-3 dans le système nerveux central, notamment le DHA, constitue l‟un des objectifs majeurs de la nutrition néonatale et infantile. Ce projet étudie l‟effet de régimes à base de matière grasse laitière anhydre (MGLA) afin d‟améliorer la bioconversion des AGPI n-3 et l‟incorporation du DHA dans le cerveau. L‟autre objectif, au-delà des effets sur les acides gras, est d‟évaluer si l‟impact des apports destinés au jeune n‟exercent pas un effet plus large tels qu‟appréciés au niveau du lipidome du cerveau.Nous avons mis au point un modèle d‟expérimentation animale permettant d‟étudier les effets de mélanges de MGLA et d‟huiles végétales. Des mères sont nourries avec un régime déficient en acide α-linoléique (ALA) (0,4% des acides gras totaux (AGT)) pendant 6 semaines avant accouplement et pendant toute la gestation et la lactation. Après sevrage, quatre-vingts petits rats mâles et femelles ainsi carencés en AGPI n-3 sont séparés en 4 groupes et reçoivent des régimes à 10% de lipides pendant 6 semaines, soit à base d‟huile de palme mélangée avec des huiles vegétales pour un apport à 1,5%ALA (P1), ou 1,5% ALA supplementé avec 0,12%DHA et 0,4% acide arachidonique (ARA) (P2); soit à base de MGLA et d‟huiles végétales apportant 1,5%ALA (B1) ou 2,3%ALA (B2). Les acides gras cérébraux, plasmatiques et érythrocytaires ainsi que le profil lipidomique cérébral sont mesurés, et les résultats sont analysés en statistiques multivariées. Le régime B1 est supérieur aux deux régimes à base d‟huile de palme à 1,5 %ALA, pour restaurer la quantité de DHA du cerveau (augmentation de 14.38%, P < 0.05) ; le régime (B2) présente un bénéfice supplémentaire sur ce paramètre. Les concentrations cérébrales en DHA chez les rats mâles sont significativement plus faibles que chez les femelles en raison des interactions de l‟effet sexe sur l‟effet régime, mais cet effet s‟atténue avec les régimes MGLA ou l‟ajout de DHA préformés dans le régime palme (P2).Nous avons calculé un nouvel indice à l‟aide des profils en acides gras des globules rouges et du plasma pour prédire le contenu en DHA cérébral, et dont la performance est meilleure que celle des indices existants. Pour la première fois, nous avons pu mettre en évidence un effet majeur et inconnu jusqu‟alors, des régimes sur le lipidome du cerveau (analyse des espèces moléculaires de lipides), affectant près de 15% des espèces analysées. Ces changements semblent être liés, entre autres, au métabolisme du cholestérol, des acides gras et des messagers lipidiques.En conclusion, nos données sont susceptibles d„améliorer les formules infantiles. La première utilisation de l‟approche de lipidomique sans a priori que nous avons mise en oeuvre ouvre des perspectives nouvelles en nutrition infantileThe accretion of docosahexaenoic acid (DHA) in brain membranes mainly occurs around delivery and during the first two years of life. One of the main goals of neonatal nutrition is to optimize the incorporation of n-3 long chain polyinsaturate fatty acids (LC-PUFA) into the central nervous system, including DHA. Our goal was to study the impact of several kinds of diets based on dairy-fat to improve the n-3 LC-PUFA bioconversion and DHA accretion into brain. The other endpoint was to assess if beyond the brain fatty acid profiles, the dietary intakes would bring about a wider effect such as the one that can be appreciated through a lipidomic approach.We compared the nutritional effect of dairy-fat based diets to that of palm-oil based diets in the rat reproductive model. Mother rats were made deficient in α-linoleic acid (ALA) (0.4% of fatty acids (FA) for 6 weeks prior to mating and throughout gestation and lactation. After weaning, the resulting deficient 40 rat pups of either gender were split into 4 groups and received 10% fat diets made with either 1.5%ALA palm oil blend (P1), same added with 0.12% DHA and 0.4% arachidonic acid (ARA) (P2) , 1.5% ALA dairy-fat blend (B1) or 2.5% ALA dairy-fat blend (B2). The brain, red blood cell (RBC) and plasma fatty acid profiles were analyzed and treated using multivariate statistics. B1 was superior to both palm-oil based diets to improve the brain DHA contents (14.4% increase, P < 0.05). B2 brought an additional benefit for this parameter. The brain DHA contents in males were significantly lower than for the female because of a diet x gender interaction. This effect was smoothed with the dairy-fat diets or the palm-oil based diet augmented with preformed DHA.We calculated a new fatty acid index to predict the brain DHA contents, based on the fatty acid profiles measured in RBC and plasma, and which demonstrated a better performance than the existing published index. For the first time, we showed a profound and yet unsuspected effect of diets until now on the brain lipidome (lipids molecular species), affecting about 15% of the features detected. These changes were ascribed to the cholesterol and fatty acid metabolism, and to the lipid messengers, among others.In conclusion, our data appear highly relevant to improve infant formulas. The first use of the lipidomic approach in neonatal nutrition open the paths of new researches in the area of infant nutrition
7
PHAM, DOMINIQUE. "Evolution du profil lipidique et lipoproteique au cours de la saison sportive chez le footballeur de haut niveau." Lyon 1, 1993. http://www.theses.fr/1993LYO1M151.
Full text
8
BARBACINI, PIETRO. "IMPACT OF VITAMIN D DEFICIENCY, DYSLIPIDEMIA AND OBESITY ON SERUM LIPIDOMIC PROFILE. SEARCH FOR NEW BIOMARKERS AS EARLY PREDICTORS OF OBESITY-ASSOCIATED COMORBIDITIES." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/710504.
Full textAbstract:
Research studies indicate that up to 58% of the world adult population will be overweight or obese by 2030 [1]. Obesity is not only related to food intake, but factors such as lifestyle and genetic background contribute to its onset [3–5]. This disease [2] is commonly associated with vitamin D (Vit. D) deficiency [6,7], and genetic associations have been identified to explain this link [8]; however, differences in dietary intake, sun exposure, or Vit. D metabolism are also involved [9]. Moreover, along with Vit. D deficiency, lipids, and particularly sphingolipids (SLs) as ceramides (Cers) and sphingomyelins (SMs) have been described as involved, not only in increasing inflammation [10,11], but also in the development of cardiovascular disease and type two diabetes [12–14], two common conditions observed in obese subjects. Given the pivotal role of SLs in obesity associated co-morbidities and the association of Vit. D, dyslipidemia and obesity, our study was aimed at profiling circulating SLs in human subjects under these conditions, in order to provide hints for the identification of new biomarkers to be introduced in clinical settings.
To define human SLs profile in obesity, dyslipidemia, and Vit. D associated deficiency, sera from 23 normal-weight normolipidemic (NWNL), 46 normal-weight, dyslipidemic, Vit. D deficient (NWDL) and 60 obese dyslipidemic, Vit. D deficient (ODL) Saudi Arabian subjects were analyzed with a dual approach, characterized by the use of two complementary techniques: the HPTLC-Primuline profiling and the LC-MS analysis. Furthermore, to define SLs profiles in the context of human adaptation to high altitude hypoxia, sera from 59 Vit. D deficient dyslipidemic children living at high altitude were analyzed by LC-MS. Children were grouped based on their BMI percentiles in 7 underweight (UW), 30 normal-weight (NW), 13 overweight (OW) and 9 obese (O).
SLs profile analysis of NWNL and ODL Saudi Arabian subjects displayed differences in total Cer and total SM caused by dyslipidemia and vitamin D deficiency, whereas specific Cers, and SMs acyl chains characterize obese subjects, only. Gender differences were found in SLs profiles independently from dyslipidemia and Vit. D status. Obesity-associated Cers, SMs, and dihydrosphingomyelins (dhSMs) specific acyl chains were identified in the NWDL vs. ODL comparison independently from dyslipidemia and Vit D status, and are thought to be drivers of increased risk of developing obesity-associated morbidities.
The analysis of SLs profiles from dyslipidemic children with Vit. D deficiency allowed to confirm the results of Saudi Arabian subjects regarding SLs association with dyslipidemia and associated Vit. D deficiency. Furthermore, SLs profile analysis led to the identification of a characteristic SLs portraits associated with BMI and related to hypoxia metabolic adaptation.
9
Paule, Philippe. "Modifications du profil lipidique dans les états fébriles et notamment infectieux." Bordeaux 2, 1993. http://www.theses.fr/1993BOR2M141.
Full text
10
Fan, Lixia. "An exploratory method for identifying reactant-product lipid pairs from lipidomic profiles of wild-type and mutant leaves of Arabidopsis thaliana." Manhattan, Kan. : Kansas State University, 2010. http://hdl.handle.net/2097/3678.
Full textBook chapters on the topic "Lipidome profile"
1
Cristina Collí-Dulá, Reyna, and Ixchel Mariel Ruiz-Hernández. "Applications of Omics Approaches to Decipher the Impact of Contaminants in Dolphins." In Marine Mammals [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102424.
Full textAbstract:
With the advent of omic technologies (genomic, transcriptomic, proteomic, metabolomic and lipidomic), it has been possible to identify global profiles of genes, proteins or metabolites in cells, tissues or organ systems at the same time. Key pathways can be identified associated with certain diseases, physiology processes or adverse effects in response to contaminants in marine organisms. This review focuses on underlining how the use of omics technology in dolphins has contributed to understanding its physiological responses and ambient stressors. They provide a basis for understanding dolphins’ physiology and a means for monitoring health conditions as well as furthering ecotoxicology studies.
2
"Lipidomic Profiles and Intervention Strategies in Prevention and Diseases." In Membrane Lipidomics for Personalized Health, 135–55. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118683682.ch8.
Full textConference papers on the topic "Lipidome profile"
1
Blanksby, Stephen, Berwyck Poad, David Marshall, Philipp Menzel, and Reuben Young. "Unknown unknowns in lipidomics: A de novo method for fatty acid discovery." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/nlsb8229.
Full textAbstract:
Current technologies for fatty acid analysis are overly reliant on the availability of reference libraries, databases and standards. This reliance is hampering the discovery of novel fatty acids and obscuring a full view of lipid metabolism across the kingdoms of life. Recent high-profile discoveries of novel lipids with site(s) of unsaturation inconsistent with canonical lipid metabolism stress the need for new technologies that can provide robust identifications of fatty acids without reliance on prior assumptions. Herein we present advances in liquid chromatography-mass spectrometry for the de novo identification and quantification of fatty acids in lipid extracts. The workflow combines fixed-charge derivatization with ozone-induced dissociation (OzID) for sensitive detection of low-abundant fatty acids with unambiguous assignment of site(s) of unsaturation. Chromatographic alignment of precursor ions with OzID transitions is undertaken using a bespoke Skyline pipeline providing unbiased identification of fatty acids over a relative concentration range spanning more than 4-orders of magnitude. Application of this analytical workflow to lipid extracts from diverse sources including human plasma, cell lines and vernix caseosa has led to the discovery of new fatty acids that point to hitherto undescribed metabolism within the source cell or organism. The description of these “unknown unknowns” particularly in well-studied systems “such as human plasma” points to a substantially great diversity in the lipidome than previously appreciated.
2
Dugo, Paola, Francesca Rigano, and Luigi Mondello. "Lipidomic analysis in food: The role of a detailed elucidation of intact lipids in functional foods for investigating on nutritional aspects." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/chnd8051.
Full textAbstract:
The growing demand in natural matrices, representing a source of dietary and nutraceutical molecules, placed, as direct consequence, the urgent need for the development of suitable analytical methods able to provide a comprehensive characterization of both “conventional” and “unconventional” products. In the last decades, lipidomic has emerged as a cutting-edge approach among omics- techniques, since lipids revealed to be essential molecules in the regulation of metabolic pathways. To this regard, the content of essential fatty acids (EFAs), as well as nutritional indices such as the levels of omega-3 and omega-6 FAs and their ratio are essential parameter to evaluate the beneficial properties of food products. In addition, the investigation of complex lipids in their native forms is proved to be crucial to obtain additional information about lipids role and on FA arrangement into each species. For this reason, the present study is aimed to a detailed elucidation of intact lipids in different functional foods, including the profiling of microalgae, hemp products and the wastes of the fish industry. Phospholipids and triacylglycerols were the most representative lipid classes. However, mono- and diacylglycerols, pigments and carotenoids were also detected, representing an added value for the investigated matrices. From an analytical point of view, the use of a recently introduced linear retention index (LRI) approach in LC paved the way for the automatization of the identification process in LC. Furthermore, the use of high-resolution chromatographic techniques (that is UHPLC), even combined with selective tandem MS operation mode allowed for the determination of the entire lipidome with high sensitivity. Finally, the UHPLC-MS/MS platform was coupled to a preparative workstation to fully automatize the analytical work-flow. This also entailed the miniaturization of the lipid extraction procedure, which was compared with a conventional manual procedure, resulting in quite similar quali-quantitative profiles.
3
Facina, G., NMCT Calux, MFR Silva, TCS Bonetti, ACP Nazario, and IDCG Silva. "P5-13-06: Lipidomic Profile Predicts Pathologic Complete Response to Neoadjuvant Weekly Paclitaxel Treatment." In Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-p5-13-06.
Full text
4
Briganti, Domenica Federica, Beatrice Aramini, Carla Kim, Robin Chan, Bowen Zhou, Somwmya Sreekanth, Kashif Raza, et al. "Differences in the lipidomic profile of bronchial washing (BW) and bronchoalveolar lavage (BAL) in lung transplanted patients." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.pa4633.
Full text
5
Briganti, Domenica Federica, Beatrice Aramini, Carla Kim, Robin Chan, Bowen Zhou, Somwmya Sreekanth, Kashif Raza, et al. "Effects of infections on lipidomic profile of bronchial washing (BW) and bronchoalveolar lavage (BAL) after lung transplantation." In ERS International Congress 2016 abstracts. European Respiratory Society, 2016. http://dx.doi.org/10.1183/13993003.congress-2016.oa3336.
Full text
6
Terao, M., V. Celestini, M. Kurosaki, A. Vallerga, M. Bolis, M. Fratelli, G. Paroni, et al. "Abstract P2-02-15: All-trans retinoic acid perturbs the lipidomic profiles of luminal breast cancer cells characterized by sensitivity to the anti-proliferative activity of the retinoid." In Abstracts: 2018 San Antonio Breast Cancer Symposium; December 4-8, 2018; San Antonio, Texas. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-p2-02-15.
Full textReports on the topic "Lipidome profile"
1
Brown Horowitz, Sigal, Eric L. Davis, and Axel Elling. Dissecting interactions between root-knot nematode effectors and lipid signaling involved in plant defense. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7598167.bard.
Full textAbstract:
Root-knot nematodes, Meloidogynespp., are extremely destructive pathogens with a cosmopolitan distribution and a host range that affects most crops. Safety and environmental concerns related to the toxicity of nematicides along with a lack of natural resistance sources threaten most crops in Israel and the U.S. This emphasizes the need to identify genes and signal mechanisms that could provide novel nematode control tactics and resistance breeding targets. The sedentary root-knot nematode (RKN) Meloidogynespp. secrete effectors in a spatial and temporal manner to interfere with and mimic multiple physiological and morphological mechanisms, leading to modifications and reprogramming of the host cells' functions, resulted in construction and maintenance of nematodes' feeding sites. For successful parasitism, many effectors act as immunomodulators, aimed to manipulate and suppress immune defense signaling triggered upon nematode invasion. Plant development and defense rely mainly on hormone regulation. Herein, a metabolomic profiling of oxylipins and hormones composition of tomato roots were performed using LC-MS/MS, indicating a fluctuation in oxylipins profile in a compatible interaction. Moreover, further attention was given to uncover the implication of WRKYs transcription factors in regulating nematode development. In addition, in order to identify genes that might interact with the lipidomic defense pathway induced by oxylipins, a RNAseq was performed by exposing M. javanicasecond-stage juveniles to tomato protoplast, 9-HOT and 13-KOD oxylipins. This transcriptome generated a total of 4682 differentially expressed genes (DEGs). Being interested in effectors, we seek for DEGs carrying a predicted secretion signal peptide. Among the DEGs including signal peptide, several had homology with known effectors in other nematode species, other unknown potentially secreted proteins may have a role as root-knot nematodes' effectors which might interact with lipid signaling. The molecular interaction of LOX proteins with the Cyst nematode effectors illustrate the nematode strategy in manipulating plant lipid signals. The function of several other effectors in manipulating plant defense signals, as well as lipids signals, weakening cell walls, attenuating feeding site function and development are still being studied in depth for several novel effectors. As direct outcome of this project, the accumulating findings will be utilized to improve our understanding of the mechanisms governing critical life-cycle phases of the parasitic M. incognita RKN, thereby facilitating design of effective controls based on perturbation of nematode behavior—without producing harmful side effects. The knowledge from this study will promote genome editing strategies aimed at developing nematode resistance in tomato and other nematode-susceptible crop species in Israel and the United States.