Academic literature on the topic 'Lipid-related disorders'
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Journal articles on the topic "Lipid-related disorders":
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Wu, Xunzhi, Zhen Chen, Yue Wu, Yifan Chen, Jiaping Jia, Nianqiu Shen, Hitoshi Chiba, and Shu-Ping Hui. "Flazin as a Lipid Droplet Regulator against Lipid Disorders." Nutrients 14, no. 7 (April 3, 2022): 1501. http://dx.doi.org/10.3390/nu14071501.
Abstract:
Lipid disorders are closely related to numerous metabolic diseases, and lipid droplets (LDs) have been considered as a new target for regulating lipid metabolism. Dietary intervention and nutraceuticals provide safe and long-term beneficial effects for treating metabolic diseases. Flazin is a diet-derived bioactive constituent mainly existing in fermented foods, of which the lipid metabolism improvement function has not been studied. In this study, the effect of flazin on lipid regulation at both cell level and organelle level was investigated. Lipidomic profiling showed that flazin significantly decreased cellular triglyceride (TG) by 12.0–22.4% compared with modeling groups and improved the TG and free fatty acid profile. LD staining revealed that flazin efficiently reduced both cellular neutral lipid content by 17.4–53.9% and LD size by 10.0–35.3%. Furthermore, nanoelectrospray ionization mass spectrometry analysis proved that flazin exhibited a preferential suppression of LD TG and regulated LD morphology, including a size decrease and surface property improvement. An evaluation of related gene expression suggested the mechanism to be lipolysis promotion and lipogenesis inhibition. These findings indicated that flazin might be an LD regulator for reversing lipid metabolism disturbance. Moreover, the strategy proposed in this study may contribute to developing other nutraceuticals for treating lipid disorder-related metabolic diseases.
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Kleme, Marie-Laure, and Emile Levy. "Cystic Fibrosis-Related Oxidative Stress and Intestinal Lipid Disorders." Antioxidants & Redox Signaling 22, no. 7 (March 2015): 614–31. http://dx.doi.org/10.1089/ars.2014.6012.
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Wang, Jiayi, Jinzhong Jing, Zhengyi Gong, Jiayong Tang, Longqiong Wang, Gang Jia, Guangmang Liu, et al. "Different Dietary Sources of Selenium Alleviate Hepatic Lipid Metabolism Disorder of Heat-Stressed Broilers by Relieving Endoplasmic Reticulum Stress." International Journal of Molecular Sciences 24, no. 20 (October 22, 2023): 15443. http://dx.doi.org/10.3390/ijms242015443.
Abstract:
As global warming continues, the phenomenon of heat stress (HS) in broilers occurs frequently. The alleviating effect of different selenium (Se) sources on HS-induced hepatic lipid metabolism disorders in broilers remains unclear. This study compared the protective effects of four Se sources (sodium selenite; selenium yeast; selenomethionine; nano-Se) on HS-induced hepatic lipid metabolism disorder and the corresponding response of selenotranscriptome in the liver of broilers. The results showed that HS-induced liver injury and hepatic lipid metabolism disorder, which were reflected in the increased activity of serum alanine aminotransferase (ALT), the increased concentration of triacylglycerol (TG) and total cholesterol (TC), the increased activity of acetyl-CoA carboxylase (ACC), diacylglycerol O-acyltransferase (DGAT) and fatty acid synthase (FAS), and the decreased activity of hepatic lipase (HL) in the liver. The hepatic lipid metabolism disorder was accompanied by the increased mRNA expression of lipid synthesis related-genes, the decreased expression of lipidolysis-related genes, and the increased expression of endoplasmic reticulum (ER) stress biomarkers (PERK, IRE1, ATF6, GRP78). The dietary supplementation of four Se sources exhibited similar protective effects. Four Se sources increased liver Se concentration and promoted the expression of selenotranscriptome and several key selenoproteins, enhanced liver antioxidant capacity and alleviated HS-induced ER stress, and thus resisted the hepatic lipid metabolism disorders of broilers exposed to HS. In conclusion, dietary supplementation of four Se sources (0.3 mg/kg) exhibited similar protective effects on HS-induced hepatic lipid metabolism disorders of broilers, and the protective effect is connected to the relieving of ER stress.
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Di, Sha, Yitian Wang, Lin Han, Qi Bao, Zezheng Gao, Qing Wang, Yingying Yang, Linhua Zhao, and Xiaolin Tong. "The Intervention Effect of Traditional Chinese Medicine on the Intestinal Flora and Its Metabolites in Glycolipid Metabolic Disorders." Evidence-Based Complementary and Alternative Medicine 2019 (June 4, 2019): 1–13. http://dx.doi.org/10.1155/2019/2958920.
Abstract:
Metabolic syndrome (MS), which includes metabolic disorders such as protein disorder, glucose disorder, lipid disorder, and carbohydrate disorder, has been growing rapidly around the world. Glycolipid disorders are a main type of metabolic syndrome and are characterized by abdominal obesity and abnormal metabolic disorders of lipid, glucose, and carbohydrate utilization, which can cause cardiovascular and cerebrovascular diseases. Glycolipid disorders are closely related to intestinal flora and its metabolites. However, studies about the biological mechanisms of the intestinal flora and its metabolites with glycolipid disorders have not been clear. When glycolipid disorders are treated with drugs, a challenging problem is side effects. Traditional Chinese medicine (TCM) and dietary supplements have fewer side effects to treat it. Numerous basic and clinical studies have confirmed that TCM decoctions, Chinese medicine monomers, or compounds can treat glycolipid disorders and reduce the incidence of cardiovascular disease. In this study, we reviewed the relationship between the intestinal flora and its metabolites in glycolipid metabolic disorders and the effect of TCM in treating glycolipid metabolic disorders through the intestinal flora and its metabolites. This review provides new perspectives and strategies for future glycolipid disorders research and treatment.
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Beaufrère, Hugues, Drury Reavill, Jill Heatley, and Leonardo Susta. "Lipid-Related Lesions in Quaker Parrots (Myiopsitta monachus)." Veterinary Pathology 56, no. 2 (September 24, 2018): 282–88. http://dx.doi.org/10.1177/0300985818800025.
Abstract:
The Quaker parrot has been used as a psittacine model to study clinical lipidology and lipid-related disorders. However, while Quaker parrots appear to be anecdotally susceptible to a variety of spontaneous dyslipidemic disorders and lesions caused by excess lipid accumulation, epidemiologic data are lacking. A multicenter retrospective study on 652 pathology submissions (411 necropsies and 243 biopsies) from Quaker parrots was performed by recording the final pathological diagnoses, age, and sex for each bird. The prevalence of lesions associated with lipid metabolism, such as hepatic lipidosis, atherosclerosis, xanthomas, adipose tumors, coelomic steatitis/steatonecrosis, endogenous lipid pneumonia, and acute pancreatic necrosis/pancreatitis, was reported. Multiple logistic regression models were used to characterize the effects of sex and age on these lesions, and the prevalence of hepatic lipidosis and atherosclerosis was compared to those in a random sample of control psittacine birds. The raw prevalence of atherosclerosis and hepatic lipidosis was 5.6% (95% confidence interval [CI], 3.4%–7.8%) and 21.2% (95% CI, 17.2%–25.1%), respectively. While the prevalence of atherosclerosis was similar to other psittacine species, hepatic lipidosis was more common in Quaker parrots. Quaker parrots also showed a unique susceptibility to acute pancreatic necrosis with a prevalence of 12.9% (95% CI, 9.7%–16.1%). Male parrots were found to be more susceptible than females to lipid accumulation lesions ( P = .0024), including atherosclerosis ( P = .018) and hepatic lipidosis ( P < .001). This retrospective study confirms the high susceptibility of Quaker parrots to lipid-related disorders and presents epidemiological data that may be useful to avian clinicians, pathologists, and researchers using Quaker parrots.
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Latruffe, Norbert. "Insights on recent advances in lipid metabolism and related disorders." Biochimie 86, no. 11 (November 2004): 741–42. http://dx.doi.org/10.1016/j.biochi.2004.10.001.
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Grummer, Ric R. "Etiology of Lipid-Related Metabolic Disorders in Periparturient Dairy Cows." Journal of Dairy Science 76, no. 12 (December 1993): 3882–96. http://dx.doi.org/10.3168/jds.s0022-0302(93)77729-2.
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Wan, Juan, Meiyan Feng, Wenjing Pan, Xin Zheng, Xinya Xie, Baozhu Hu, Cuiqin Teng, et al. "Inhibitory Effects of Six Types of Tea on Aging and High-Fat Diet-Related Amyloid Formation Activities." Antioxidants 10, no. 10 (September 24, 2021): 1513. http://dx.doi.org/10.3390/antiox10101513.
Abstract:
Aging and lipid metabolism disorders promote the formation and accumulation of amyloid with β-sheet structure, closely related to cardiovascular disease, senile dementia, type 2 diabetes, and other senile degenerative diseases. In this study, five representative teas were selected from each of the six types of tea, and a total of 30 teas were selected to evaluate the inhibitory activities on the formation of aging-related amyloid in vitro. The results showed that the 30 teas had a significant inhibitory effect on the formation activity on aging-related amyloid at the protein level in vitro. Although the content of catechins is relatively low, black tea and dark tea still have significant antioxidant activity and inhibit the formation of amyloid. A high-fat diet established the model of lipid metabolism disorder in premature aging SAMP8 mice, and these mice were gavaged different tea water extracts. The results showed that different tea types have a significant inhibitory effect on the formation of β-amyloid and Aβ42 mediated by age-related lipid metabolism disorders, and the in vivo activity of fully fermented teas was better than that of green tea. The action mechanism was related to antioxidation, anti-inflammatory, and improving lipid metabolism.
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Vučević, Danijela, Drago Đorđević, Marija Stanojević, Bojan Jorgačević, Danka Đorović, Đorđe Radak, and Tatjana Radosavljević. "Hypercholesterolemias: Pathogenesis and pathophysiological implications." Medicinska istrazivanja 50, no. 2 (2016): 30–43. http://dx.doi.org/10.5937/medist1602030v.
Abstract:
In this review, we provide an overview of recent literature data and practical knowledge related to hypercholesterolemias and their pathophysiological implications. Elevated blood lipid levels (hyperlipidaemias) are the most common metabolic disorders in global population. There is consensus regarding hypercholesterolemia, hypertension and cigarette smoking as the three main risk factors for atherothrombosis, with consequences such as cardiovascular and cerebrovascular diseases, being the leading cause of morbidity and mortality worldwide. In relation to this, familial hypercholesterolemia is the most deleterious precursor of coronary artery disease. This severest form of hyperlipidaemia refers to an inherited disorder of cholesterol metabolism due to defects in the receptor for low density lipoprotein (LDL). Besides, numerous factors, including drugs, can influence lipid status and significantly contribute to the development of secondary hypelipidaemias. Thus, inappropriate diet, obesity, diabetes mellitus and alcohol use, in particular, are commonly associated with high blood lipid levels. Therefore, secondary causes of high blood lipids should be considered in each patient with a lipid disorder before lipid-lowering therapy is started. Having in mind the increase of prevalence of lipid metabolism disorders in future, it is necessary to take preventive actions to decrease risk factors (inappropriate diet rich in carbohydrates and saturated fat, obesity, cigarette smoking, sedentary lifestyle and physical inactivity). However, although various studies related to this medical problem have been carried out, scientists are still far from a complete understanding of the molecular basis of this problem.
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Belamarich, Peter F. "Lipoprotein Disorders." Pediatrics In Review 17, no. 4 (April 1, 1996): 144. http://dx.doi.org/10.1542/pir.17.4.144.
Abstract:
Although symptomatic lipoproteinemias are rare in childhood, early detection often can prevent severe complications. Abetalipoproteinemia is characterized by severe hypolipidemia, fat malabsorption, failure to thrive, unusual spiculated erythrocytes known as acanthocytes, and progressive neuromuscular and retinal pigmentary degeneration believed to be related to vitamin E deficiency. Plasma triglyceride concentrations are so low as to be frequently undetectable, and cholesterol concentrations typically are less than 50% of normal. This disorder results from an inability of both enterocytes and hepatocytes to secrete their apoprotein B-containing lipoproteins. Consequently, chylomicrons, very low-density lipoprotein are absent from plasma. A related disorder, homozygous familial hypobetalipoproteinemia, mimics the signs and symptoms and the characteristic lipid levels of abetalipoproteinemia, but is believed to involve a different mutation.
Dissertations / Theses on the topic "Lipid-related disorders":
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Kuznetcova, Daria. "Development and characterization of chia (Salvia hispanica L.) plant-derived products as natural bioactive compounds." Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0266.
Abstract:
Les acides gras polyinsaturés (AGPI) oméga-3 sont importants pour la nutrition et la santé, en raison de leur importance dans l'homéostasie des lipides, et du fait que les carences en AGPI peuvent augmenter le risque de syndrome métabolique, de maladies cardiovasculaires et neurodégénératives. Les graines de chia (Salvia hispanica L.) sont riches en AGPI (80%) et contiennent les plus hauts niveaux connus dans les plantes de l’acide gras essentiel oméga-3, l'acide alpha-linolénique (ALA). Un degré élevé d'insaturation dans les huiles comestibles peut réduire la stabilité oxydative, entraînant une perte de valeur nutritionnelle. Les nanotechnologies peuvent être utilisées pour améliorer la qualité et la sécurité des huiles de graines de chia, augmenter la biodisponibilité et élargir le champ des applications. Dans cette optique, notre objectif était de préparer et de caractériser les lipides des graines de chia sous forme de nanoliposomes (NL) et de nanoémulsions (NE), et d'évaluer leur utilisation potentielle en tant que produits bioactifs. Dans une première étape, les fractions de lipides ont été caractérisées. Les lipides ont été extraits de la variété française ORURO de graines de chia en utilisant la méthode Folch modifiée. Dix espèces d'acides gras et six classes de phospholipides (PL) ont été identifiées dans l'extrait de lipides de graines de chia par chromatographie en phase gazeuse et LC-MS, respectivement, le niveau le plus élevé d'acides gras étant l'ALA (62%). La présence d'un résidu solide a été détectée suite à l'évaporation du solvant pour obtenir l'huile de graine de chia. Les analyses par chromatographie sur couche mince et par LC-MS ont démontré que ce résidu contenait les lipides polaires, y compris des PL, qui n'étaient plus présents dans l'huile de chia après l'élimination du solvant par évaporation. Les NE ont été préparés à partir de l'huile de chia et du résidu solide riche en PL du chia, et les NL à partir du résidu solide riche en PL. La caractérisation physicochimique, y compris l'analyse de l'indice de polydispersité (PDI), de la taille et du potentiel zêta, a indiqué que les NE et NL étaient des solutions monodisperses de particules stables (faible potentiel zêta négatif) d'une taille entre 104 et 118 nm. Ces préparations étaient sphériques et multilamellars (microscopie électronique à transmission), et restaient stables même 5 jours après leur préparation. De plus, un test enzymatique a confirmé la présence des PL dans les NE et les NL à la base de chia. Le test de viabilité cellulaire MTT a montré peu ou pas de toxicité cellulaire (jusqu'à 150 µg/ml NE ou NL) après incubation de 24 heures avec des hépatocytes, des neurones et des astrocytes cultivés. En conclusion, ces résultats démontrent la faisabilité de l'utilisation des lipides du chia pour la préparation de NL et NE de chia, stables et non toxiques, riches en AGPI oméga-3, qui représentent des vecteurs bioactifs potentiels pour des applications préventives et thérapeutiques en santé humaineOmega-3 polyunsaturated fatty acids (PUFA) are important for nutrition and health, by virtue of their importance in lipid homeostasis, and the fact that PUFA deficiencies can increase risk of metabolic syndrome, cardiovascular and neurodegenerative diseases. Chia (Salvia hispanica L.) seeds are rich in PUFA (80%) and contain the highest known levels in plants of the essential omega-3 fatty acid, alpha-linolenic acid (ALA). High degree of unsaturation in edible oils can reduce oxidative stability causing a loss of nutritional value. Nanotechnology can be used to improve chia seed oil quality and safety, increase bioavailability, and expand the scope of applications. Towards this goal, our objective was to prepare and characterize chia seed lipids in the form of nanoliposomes (NL) and nanoemulsions (NE), and to evaluate their potential use as bioactive products. The first step was to characterize lipid fractions. Lipids were extracted from the French ORURO variety of chia seeds using modified Folch method. Ten fatty acid species and six phospholipid (PL) classes were identified in chia seed lipid extract by gas chromatography and LC-MS, respectively, with the highest level of fatty acids being ALA (62%). The presence of a solid residue was detected following evaporation of the solvent to obtain chia seed oil. Analyses by thin layer chromatography and LC-MS demonstrated that this residue contained the polar lipids including PL that were no longer in the chia oil after removal of solvent by evaporation. NE were prepared from chia seed oil and the chia PL-rich solid residue, and NL from the PL-rich solid residue. Physicochemical characterization including analysis of the polydispersity index (PDI), size, and zeta-potential indicated that both NE and NL were monodispersed solutions of stable (low negative zeta potential) particles with a size between 104-118 nm. These preparations were spherical and multilayered (transmission electron microscopy) and remained stable even 5 days after preparation. In addition, enzymatic assay confirmed PL content in both NE and NL. MTT cell viability assay showed little to no cell toxicity (up to 150 µg/mL NE or NL) following 24 h incubation with cultured hepatocytes, neurons, and astrocytes. In conclusion, these results demonstrate the feasibility of using chia lipids for the preparation of stable non-toxic omega-3 PUFA rich NL and NE, which represent potential bioactive vectors for both preventive and therapeutic applications in human health
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Martins, Susana Isabel Vargas. "New insights into biological effects of conjugated linoleic acid and saturated fats in body fat composition, obesity and related disorders: experimental studies in normal-weight Wistar and obese Zucker rats." Doctoral thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2010. http://hdl.handle.net/10400.5/1770.
Abstract:
Tese de Doutoramento em Ciência e Tecnologia AnimalThe daily intake of conjugated linoleic acid (CLA) isomers by humans, through diet and supplementation, and the controversial effects of these compounds in human health, were the main motivation for the elaboration of this thesis. Firstly, the present work intended to estimate the daily CLA ingestion by the Portuguese population. Secondly, the biological effects of CLA were exploited using two distinct animal models, normal-weight (Wistar rat) and genetically fat (obese Zucker rat), in combination with saturated fat based diets. The estimative of total CLA intake for the Portuguese population was 73.70 mg/day. The cis(c)9,trans(t)11 and t7,c9 were the most prevalent CLA isomers, with, respectively, 76.10 and 12.56% of the total CLA intake value. Concerning the animal trials, CLA in conjugation with saturated fats revealed beneficial but also deleterious biological effects. In the normal-weight Wistar rat fed a palm oil based diet, the administration of c9,t11 CLA isomer increased the serum triacylglycerols and the size of adipocytes from epididymal and retroperitoneal fat depots. In addition, a CLA mixture of c9,t11 and t10,c12 isomers increased the glycerol membrane permeability of kidney proximal tubules, which may indicate an improvement of glycerol reabsorption pathway. In the obese Zucker rat, CLA (as a mixture) induced changes in fatty acid profile of liver, muscle and adipose depots. CLA supplemented with a vegetable saturated fat diet seemed to promote a more beneficial adipokine serum profile and an alleviation of hepatic steatosis. In contrast, adverse effects of CLA were observed with hypercholesterolaemia promotion. Regardless CLA, the ovine fat diets worsened the insulin resistance and increased the pro-inflammatory serum cytokines. In the liver, different levels of cell death and apoptotic pathways were modulated by CLA, depending on the type of saturated fat present in the diet. The most striking result of this study was that CLA was not able to promote fat loss in both experimental models. Moreover, new mechanisms of CLA action were disclosed in this work, which reinforce the need to further investigate this compound.
RESUMO - Efeitos biológicos do ácido linoleico conjugado e de gorduras saturadas na composição da gordura corporal, na obesidade e patologias associadas: estudos experimentais em ratos Wistar e Zucker obesos - A ingestão diária de isómeros do ácido linoleico conjugado (CLA), através da dieta e da sua suplementação, bem como, os efeitos controversos destes compostos na saúde humana, constituíram a principal motivação para a elaboração desta tese. Numa primeira fase, o trabalho pretendeu estimar a ingestão diária de CLA pela população Portuguesa. Posteriormente, foram avaliados os efeitos biológicos do CLA quando suplementado a dietas à base de gordura saturada. Para tal, recorreu-se a dois modelos animais distintos, o rato Wistar e o rato Zucker (geneticamente obeso). A ingestão média total de CLA pela população Portuguesa foi estimada em 73.70 mg/dia. Os isómeros do CLA mais representativos foram o cis(c)9,trans(t)11 e o t7,c9, correspondendo, respectivamente, a 76.10 e 12.56% do total de CLA ingerido. Quanto aos estudos in vivo, o CLA revelou efeitos biológicos tanto benéficos como prejudiciais. No modelo Wistar alimentado com dieta à base de óleo de palma, a administração do isómero do CLA c9,t11 elevou os níveis de triacilgliceróis no soro, bem como, o tamanho dos adipócitos das gorduras epididimal e retroperitoneal. Adicionalmente, a mistura de isómeros do CLA (c9,t11 e t10,c12) aumentou a permeabilidade membranar ao glicerol no túbulo proximal do rim, sugerindo uma melhoria no processo de reabsorção desta molécula. No modelo Zucker, o CLA (como mistura de isómeros) induziu alterações no perfil dos ácidos gordos do fígado, músculo e gorduras epididimal e retroperitoneal. O CLA administrado com óleo de palma promoveu um perfil de adipocinas no soro mais benéfico e melhorou a esteatose hepática. Em contraste, a suplementação com CLA apresentou um efeito hipercolesterolémico. Independentemente do CLA, a dieta rica em gordura de ovinos agravou a resistência à insulina e aumentou as adipocinas pró-inflamatórias no soro. No fígado, diferentes níveis de morte celular e vias apoptóticas foram modeladas pelo CLA em função do tipo de gordura presente na dieta. É de salientar que não se observaram efeitos anti-adipogénicos do CLA em nenhum dos dois modelos animais. Por último, esta tese contribuiu para a descoberta de novos mecanismos de acção dos isómeros do CLA, reforçando a necessidade de continuar a estudar estes compostos.
This work was funded by Fundação para a Ciência e a Tecnologia (FCT) through the individual fellowship SFRH/BD/22566/2006 and co-financed by the grant POCTI/44750/2002
Books on the topic "Lipid-related disorders":
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Evert, Alison B., and Marion J. Franz. American Diabetes Association guide to medical nutrition therapy for diabetes. 2nd ed. Alexandria, Va: American Diabetes Association, 2012.
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Jardine, Alan G., and Rajan K. Patel. Lipid disorders of patients with chronic kidney disease. Edited by David J. Goldsmith. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0102.
Abstract:
The risk of developing cardiovascular (CV) disease is increased in patients with chronic kidney disease (CKD) and although dyslipidaemia is a major contributory factor to the development of premature CV disease, the relationship is complex. Changes in lipid fractions are related to glomerular filtration rate and the presence and severity of proteinuria, diabetes, and other confounding factors. The spectrum of CV disease changes from lipid-dependent, atheromatous coronary disease in early CKD to lipid-independent, non-coronary disease, manifesting as heart failure, and sudden cardiac death in advanced and end-stage renal disease. Statin-based lipid-lowering therapy is proven to reduce coronary events across the spectrum of CKD. The relative reduction in overall CV events, however, diminishes as CKD progresses and the proportion of lipid-dependent coronary events declines. There is nevertheless a strong argument for the use of statin-based therapy across the spectrum of CKD. The argument is particularly strong for those patients with progressive renal disease who will eventually require transplantation, in whom preventive therapy should start as early as possible. The SHARP study established the benefits and endorses the use of lipid-lowering therapy in CKD 3-4 but uncertainty about the value of initiation of statin therapy in CKD 5 remains. There is, however, no rationale for stopping agents started earlier in the course of the illness for compelling indications, particularly in those who will ultimately be transplanted. The place of high-density lipoprotein-cholesterol raising and triglyceride lowering therapy needs to be assessed in trials. Modifying dyslipidaemia in CKD has demonstrated that lipid-dependent atheromatous cardiovascular disease is only one component of the burden of CV disease in CKD patients, that this is proportionately less in advanced CKD, and that modification of lipid profiles is only one part of CV risk management.
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Sills, Irene N., and Martin M. Fisher, eds. AM:STARs: Advances in the Treatment of Endocrine Disorders in Adolescents, Vol. 26, No. 2. American Academy of Pediatrics, 2015. http://dx.doi.org/10.1542/9781581109498.
Abstract:
There are a series of endocrine disorders that can affect adolescents, some of which are related to growth and development and others that can occur at any age but may have specific implication for the adolescent age group. This issue provides a comprehensive update of endocrine issues seen in adolescents, with a focus on recent advances in diagnosis and treatment. Contents in Advances in the Treatment of Endocrine Disorders in Adolescents include Thyroid Disorders Update on Diabetes Melitus Disorders of Growth and Puberty Bone Health in Adolescents Polycystic Ovarian Syndrome Adrenal Disorders Lipid Disorders Endocrine Disorders in Pregnancy Endocrine Abnormalities in Patients with Eating Disorders Turner syndrome and Klinefelter Syndrome Disorders of Sex Development Endocrine Disorders in Adolescent Cancer Survivors
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American Diabetes Association guide to medical nutrition therapy for diabetes. Alexandria, Va: American Diabetes Association, 1999.
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Association, American Diabetes. American Diabetes Association Guide to Medical Nutrition Therapy for Diabetes (Clinical Education Series). American Diabetes Association, 2003.
Book chapters on the topic "Lipid-related disorders":
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Noah, Kelly, and Elaine Tierney. "Lipid-Related Pathophysiology of ASD." In Neurobiology of Autism Spectrum Disorders, 145–66. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-42383-3_8.
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Abouakil, Nehza, Ewa Rogalska, and Dominique Lombardo. "One Step Purification of Pancreatic Cholesterol Ester Hydrolase: Application to the Related Enzyme of Human Milk." In Lipid Storage Disorders, 539–43. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1029-7_67.
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Bogaievsky, Y., F. Torossian, G. Jost, and F. Bonnefous. "Clinical Effect of Lipanthyl on Tinnitus Aurium and Other Symptoms Related to Inner Ear Disorders." In Drugs Affecting Lipid Metabolism, 343–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71702-4_64.
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Taguchi, Ryo, Kazutaka Ikeda, and Hiroki Nakanishi. "Lipidomics for Elucidation of Metabolic Syndrome and Related Lipid Metabolic Disorder." In Lipidomics, 233–50. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2012. http://dx.doi.org/10.1002/9783527655946.ch12.
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Suksangrat, Tanapa, Phatchariya Phannasil, and Sarawut Jitrapakdee. "miRNA Regulation of Glucose and Lipid Metabolism in Relation to Diabetes and Non-alcoholic Fatty Liver Disease." In Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders, 129–48. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-12668-1_7.
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"Lipid Peroxidation and Age-Related Neurodegenerative Disorders." In Lipid Oxidation in Health and Disease, 350–83. CRC Press, 2015. http://dx.doi.org/10.1201/b18138-21.
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Dubowitz, Victor, and Caroline A. Sewry. "Metabolic myopathies II: Lipid related disorders and mitochondrial myopathies." In Muscle Biopsy, 469–92. Elsevier, 2007. http://dx.doi.org/10.1016/b978-1-4160-2593-1.50023-1.
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Shilpi, Satish, Ashish Jain, Sonal Dixit, Gaurav Saraogi, Awesh K. Yadav, and Sanjay K. Jain. "Lipid nanocarrier-based drug delivery for the treatment of brain-related disorders." In Nanomedical Drug Delivery for Neurodegenerative Diseases, 55–65. Elsevier, 2022. http://dx.doi.org/10.1016/b978-0-323-85544-0.00014-9.
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Harun, Harnavi. "Lipid Peroxidation: Aging Kidney." In Lipid Peroxidation [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95801.
Abstract:
Kidney is one of the tissues affected by age that involves cellular and structural changes inside the kidney and notably implicates with comorbidity, related to cardiovascular disease aging. Aging kidney causes the elderly susceptible to clinical deterioration from ordinary stimulation that younger individual can compensate, including acute renal injury, volume depletion or overload, sodium and potassium level disorders, and toxic reaction against kidney excreted drugs. As one of the organs with the fastest aging rate, kidney shows several age-related decline in both structural and functional with 30% of the glomerulus are damaged and represent diffuse glomerular sclerosis by age 75 and explain why the prevalence of chronic kidney disease (CKD) and end-stage renal disease are very common in the elderly. The cross-sectional population-based study by The National Health and Nutrition Examination Survey supports the theory of age-related decline in kidney function, although some other subjects did not have an absolute decline in kidney function. The underlying molecular mechanisms could be the target of future therapeutic strategies. Aging is a natural biological process characterized by a gradual decline in cellular function as well as progressive structural change of organ systems. In aging kidney, there are interactions of genetic factors, environmental changes, and cellular dysfunction that lead to the typical structural and functional changes. One of the most popular theory of aging is the theory of free radicals or oxidative stress based on the fact that cells are under chronic oxidative stress due to an imbalance between pro oxidants and antioxidants. Reactive oxygen species are oxygen-derived oxidizing compounds that are highly reactive, consisting of free radicals and non-radicals. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) refer to both reactive radicals and non-radical derivatives of oxygen and nitrogen. Reactive oxygen and nitrogen species (RONS) are produced by all aerobic cells and play an important role in aging as well as age-related diseases. Lipid peroxidation is a process of oxidative degradation of lipids that process by which free radicals bind to lipid electrons in the cell membrane resulting in direct cell damage. Lipid peroxidation can cause cellular damage in several ways such as impairing the integrity of the plasma membrane and subcellular organelles by peroxidation, “chain reaction” of ROS production, and activation of phospholipase A2 (PLA2) caused by lipid peroxidation. Fatty acids and other PLA2 metabolites (such as lysophospholipids) are known to damage cell membranes. In the development of kidney damage, the process of lipid peroxidation plays an important role. This is presumably due to the large number of long-chain polyunsaturated fatty acids (PUFAs) in the lipid composition of the kidneys and there are substantial evidence to suggest that ROS is involved in the ischemic, toxic, and immunologically mediated pathogenesis of renal injury, but the cellular mechanisms that result in cell injury and death are still being studied.
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Hafeez, Abdul, and Shazia Afzal Usmani. "Perspective Chapter: Nose-to-Brain Drug Delivery through Liposomes - Recent Applications." In Liposomes - Recent Advances, New Perspectives and Applications. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.106374.
Abstract:
Diseases related to the brain are causing a huge problem worldwide. Different drug formulations are available for the management of brain-related disorders, but due to less drug availability for the brain and non-specificity, it becomes difficult to completely cure life-threatening brain disorders. The blood-brain barrier (BBB) restricts the entry of drug molecules/drug-loaded carriers because of the presence of various efflux transporters and drug inactivating enzymes. Researchers have identified an intranasal route for direct delivery to the brain, bypassing BBB. Nanotechnology-enabled lipid-based drug carrier systems have shown potential for the management of brain diseases through nose-to-brain delivery. Liposomes are the most extensively investigated carrier systems because of biocompatibility, controlled release characteristics, easy surface modification, and biodegradability. This chapter highlights the important aspects of nose-to-brain delivery and strategies for enhancing the availability of drugs through liposomes in the management of different brain-related diseases.
Conference papers on the topic "Lipid-related disorders":
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Kaya Bingöl, Züleyha, Gulseren Sagcan, Hacer Durmus Tekce, Piraye Serdaroglu, and Esen Kiyan. "Pulmonary functions and sleep related breathing disorders in lipid storage disease." In ERS International Congress 2017 abstracts. European Respiratory Society, 2017. http://dx.doi.org/10.1183/1393003.congress-2017.oa4842.
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Glanao, Jean-Marie, and Thierry Durand. "The wonders of isoprostanoids in biological systems." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/mwci6999.
Abstract:
Isoprostanoids are low abundance lipids derived from non-enzymatic oxidation of polyunsaturated fatty acids (PUFA). Despite the concentration of these molecules to be low (picogram to milligram) in biological specimen, it appears to have fundamental roles especially when under oxidative stress. The two most evaluated isoprostanoids are those derived from arachidonic acid and docosahexaenoic acid, namely 15-F2t-Isoprostane and 4-F4t-Neuroprostane respectively. The former is renown to be general biomarker of in vivo oxidative stress whilst the latter is more known to be a bioactive lipid mediator and oxidative stress biomarker related to specific neurological disorders. Giving credit to the total synthesis of the standards and the development of mass spectrometry namely LC-MS/MS, measurement of other types of isoprostanoids has been possible. Insofar, we have discovered dihomo-isoprostanes from adrenic acid, new types of phytoprostanes from alpha-linolenic acid, and more recently phytoprostanes from gamma-linolenic acid and stearidonic acid. Over 10 years of investigation in cells, tissues from crabs, corals, rodents etc., biological fluids from rodents and human, plants namely algae, nuts and seeds, the level of these isoprostanoids although low in concentration, become significant depending on the oxidative stress status, inflammation and pathophysiological process, as well as the existence of PUFA. In this presentation, the significance of some isoprostanoids found in biological systems will be discussed.
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Ahmed, Amira, Huda Farah, Omnia Ahmed, Dina Elsayegh, Abdelrahman Elgamal, and Nasser Moustafa Rizk. "Profile Of Oxidative Stress Genes In Response To Obesity Treatment." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0150.
Abstract:
Background: Oxidative stress (OS) is an imbalance between free radical production and the antioxidants defense in the body. Previous studies demonstrated the correlation of OS to the increased risk of developing metabolic disorders such as obesity. Sulforaphane (SFN), a bioactive compound, can protect against inflammation and OS, thus an effective anti-obesity supplement. Aim: This study explores the impact of SNF on OS in diet induced obese (DIO) mice via profiling of OS genes and pathways in skeletal muscles related to the anti-obesity effect. Methods: Wild-type CD1 male mice and the knockout of nuclear factor (erythroid-derived 2) like 2 (NrF2) mice were fed a high-fat diet (HFD) for 16 weeks; to induce obesity. Subsequently, each group was subdivided into two subgroups and received either Vehicle (25μl) or SFN (5 mg/kg BW) for four weeks. Body weight was measured daily, and a glucose tolerance test (GTT) was performed after 21 days of treatment. Afterward, mice were decapitated, blood and tissue samples were collected and snap-frozen immediately. Total RNA was extracted from Skeletal muscle and epididymal white adipose tissue (eWAT), leptin expression was measured in (eWAT), and 84 OS genes in skeletal muscle were examined using RT-PCR. Results: Significant reduction in body weight in SFN treated WT mice, while no change in KO mice. Plasma glucose, leptin, and leptin gene expression (eWAT) were significantly reduced in the WT-DIO SFN treated group, while no changes were detected in KO mice. SFN decreases OS damage in skeletal muscles, such as lipid peroxidation and production of reactive oxygen species (ROS). Conclusion: This study demonstrated that SFN had lowered body weight in WT-DIO mice by decreasing OS damage in skeletal muscles through the NrF2 pathway and can be a potential anti-obesity drug.
Reports on the topic "Lipid-related disorders":
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LI, Peng, and Junjun Liu. Effect of statin therapy on moderate-to-severe depression: an updated systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0016.
Abstract:
Review question / Objective: We aim to assess the antidepressant effects of statin therapy among patients complicated with moderate to severe depression. Condition being studied: Depression is one of the major causes of disability worldwide, and major depressive disorders (MDD) contribute to a significant heavy disease burden, which is expected to be second by 2050, only to heart disease. Despite great improvement in therapy, the treatment efficacy remains low. Therefore, alternative therapies have been intensely investigated. A substantial body of researches have suggested that inflammation is one of the operative pathways between MDD and increased risk of somatic comorbidities, and some specific depressive symptoms. Depression occurs in most patients with cardiac and cerebrovascular disease due to the long-term effects, and depression increases the risk of cardiovascular disease in the population as a whole and in patients with coronary artery disease or stroke. Several observational studies have demonstrated reduced rates of depression among patients taking statins, which may be related to its anti-inflammatory effect. However, whether statin improves the depressive symptoms and its associated mechanism is still mixed. Furthermore, there is little evidence about statin treatment effect in those with moderate to severe depression. In addition, whether the effect of statin treatment on depressive symptom changes with time or is affected by baseline depression severity or percentage change of lipid levels has not been explored in previous studies.