Dissertations / Theses on the topic 'Lipid based delivery systems'
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Mok, Kenneth W. C. "Characterization of lipid-based DNA delivery systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34590.pdf.
Full textJørgensen, Lene. "Lipid based drug delivery systems for parenteral delivery of proteins /." Cph. : Department of Pharmaceutics, the Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/lenejoergensen.htm.
Full textBrinkmann, Joscha [Verfasser]. "Thermodynamics of Lipid-Based Drug Delivery Systems / Joscha Brinkmann." München : Verlag Dr. Hut, 2021. http://d-nb.info/1238423043/34.
Full textPan, Xiaogang. "Design and evaluation of lipid based delivery systems for delivery of small molecules and macro-molecular nucleotides based therapeutic agents." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164679618.
Full textLam, Angela Man Iu. "Influence of calcium on the transfection properties of lipid-based gene delivery systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61130.pdf.
Full textKleemann, Elke. "Polyethylenimine- and lipid-based nanoparticles as gene and drug delivery systems for aerosol therapy to the lung." [S.l.] : [s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0363/.
Full textHelena, (nee Slabbert) Chrizaan. "Formulation, characterization and cellular toxicity of lipid based drug delivery systems for mefloquin / Chrizaan Helena (nee Slabbert)." Thesis, North-West University, 2011. http://hdl.handle.net/10394/8433.
Full textThesis (Ph.D. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2011
Jarzębińska, Anita [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Lipid-based delivery system for chemically modified mRNA / Anita Jarzębińska ; Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1136270884/34.
Full textBrody, Leigh. "Design, synthesis and biological evaluation of novel lipid-based nanoparticle delivery system for metabolic re-engineering." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14406.
Full textSchwab, Martin. "Degradation of lipid based drug delivery systems and characterization of semi-synthetic spider silk proteins for the application in pharmaceutical technology." Diss., Ludwig-Maximilians-Universität München, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-165238.
Full textGujrati, Maneesh. "Development of a Multifunctional Cationic Lipid-Based siRNA Delivery System for the Treatment of Triple-Negative Breast Cancer." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1432742230.
Full textSong, Lin. "STUDIES OF SOLUBILIZATION OF POORLY WATER-SOLUBLE DRUGS DURING IN VITRO LIPOLYSIS OF A MODEL LIPID-BASED DRUG DELIVERY SYSTEM AND IN MIXED MICELLES." UKnowledge, 2011. http://uknowledge.uky.edu/pharmacy_etds/1.
Full textSchwab, Martin [Verfasser], and Gerhard [Akademischer Betreuer] Winter. "Degradation of lipid based drug delivery systems and characterization of semi-synthetic spider silk proteins for the application in pharmaceutical technology / Martin Schwab. Betreuer: Gerhard Winter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1046785257/34.
Full textKlein, Sandra Verfasser], Karsten [Akademischer Betreuer] [Mäder, Markus [Akademischer Betreuer] Pietzsch, and Thomas [Akademischer Betreuer] Rades. "In vitro lipolysis assay as a prognostic tool for the development of lipid based drug delivery systems / Sandra Klein. Betreuer: Karsten Mäder ; Markus Pietzsch ; Thomas Rades." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2013. http://d-nb.info/1031189815/34.
Full textCarradori, Dario. "Novel nanoparticle-based drug delivery system for neural stem cell targeting and differentiation." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0056/document.
Full textNeural stem cells (NSCs) are located in specific regions of the central nervous system called niches. Those cells are able to self-renew and to differentiate into specialized neuronal cells (neurons, astrocytes and oligodendrocytes). Due to this differentiation property, NSCs are studied to replace neuronal cells and restore neurological functions in patients affected by neurodegenerative diseases. Several therapeutic approaches have been developed and endogenous NSC stimulation is one of the most promising. Currently, there is no active molecule or therapeutic system targeting endogenous CSNs and inducing their differentiation at the same time. The aim of the work was to provide a drug delivery system able both to target endogenous CSNs and to induce their differentiation in situ. Here, we developed and characterized lipidic nanoparticles (LNC) targeting endogenous NSCs. A peptide called NFL-TBS.40-63, known for its affinity towards NSCs, was adsorbed at the surface of LNC. We observed that NFL-LNC specifically targeted NSC from the brain and not from the spinal cord in vitro and in vivo. To explain this specificity, we characterized and compared NFL-LNC interactions with the plasmatic membrane of both cell types. Finally, we demonstrated that by loading retinoic acid in NFL-LNC we were able to induce brain NSC differentiation in vitro and in vivo. This work contributes to the development of efficient and safe therapies for the treatment of neurodegenerative disease via the differentiation of endogenous NSCs
Cao, Yichen. "APPLICATION OF LINEAR FREE ENERGY RELATIONSHIPS IN THE PREDICTION OF TRIGLYCERIDE/WATER PARTITION COEFFICIENTS AND LIPID BILAYER PERMEABILITY COEFFICIENTS OF SMALL ORGANIC MOLECULES AND PEPTIDES." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/655.
Full textMyschik, Julia, and n/a. "Immunostimulatory lipid implants as delivery systems for model antigen." University of Otago. School of Pharmacy, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080806.114447.
Full textZhang, Mengzi. "DEVELOPMENTS OF LIPID-BASED NANOPARTICLES FOR THERAPEUTIC DRUG DELIVERY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417025932.
Full textAl, Sukhun Rajaa Abed El-Kader. "Lipid drug delivery systems and their fate after oral administration." Thesis, University of Bath, 2002. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665369.
Full textSquire, Marie A. "Protein-based drug delivery systems." Thesis, University of Canterbury. Chemistry, 2004. http://hdl.handle.net/10092/6518.
Full textLiu, Weipeng. "Biopolymer-based ocular drug delivery systems." Diss., Connect to online resource - MSU authorized users, 2008.
Find full textMohamed, Noor Norhayati. "Lipid-based nanoparticles for topical delivery of hair growth therapeutic molecules." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10024622/.
Full textSolomon, Linda Joy. "Lipid-based formulations for oral delivery of poorly water-soluble drugs." Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263231.
Full textTriplett, Michael David. "Enabling solid lipid nanoparticle drug delivery technology by investigating improved production techniques." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1101830018.
Full textTitle from first page of PDF file. Document formatted into pages; contains xv, 172 p.; also includes graphics (some col.). Includes bibliographical references (p. 161-172).
Cheng, Xinwei. "Development of a Lipid Nanoparticle-based Antisense Delivery Platform for Cancer Therapy." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu154323360801958.
Full textSenderoff, Richard I. "Development of fibrin-based drug delivery systems /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487677267728699.
Full textWebster, Alexandra Margaret. "Design, synthesis and delivery of peptide-based systems." Thesis, Durham University, 2018. http://etheses.dur.ac.uk/12616/.
Full textMackenzie, R. C. "Computational modelling of polymer-based drug delivery systems." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/28852/.
Full textGuiheneuf, Thierry Michel Herve. "Magnetic resonance imaging of meat- and lipid-based food systems." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627488.
Full textDeng, Ni. "A secure, payment-based email delivery system." CSUSB ScholarWorks, 2005. https://scholarworks.lib.csusb.edu/etd-project/2909.
Full textOh, Sejin. "Development of mucus permeating nanoparticles-based drug delivery systems." Doctoral thesis, Universitat Ramon Llull, 2016. http://hdl.handle.net/10803/382626.
Full textExiste un interés creciente, tanto en el mundo académico como en la investigación industrial en el desarrollo de sistemas de liberación de fármacos macromoleculares (proteínas, péptidos, oligonucleótidos) capaces de atravesar la mucosa. En este sentido, la utilización de vectores sintéticos para la liberación de dichas macromoléculas, permite disponer de una plataforma versátil y altamente eficiente. Sin embargo, la capa de mucosa con propiedades adhesivas y altamente viscoelástica, tiene una elevada capacidad de atrapar y eliminar cualquier sustancia extraña que quede adherida sobre su superficie, limitando, de forma evidente, la eficacia de cualquier tratamiento Esta Tesis se centra en el desarrollo de sistemas de liberación de ADN, diseñados a medida, que presentan una elevada estabilidad y eficacia de transfección con un nivel muy bajo de toxicidad y muy importante en el contexto de la tesis, una capacidad de permeación a través de la mucosa. Además la tesis también se centra en el diseño y el desarrollo de métodos y técnicas in vitro que ayuden a una mejor selección de sistemas eficientes de liberación a través de la mucosa. Así se ha desarrollado un método simple y eficiente, basado en la utilización de una microbalanza de cuarzo con disipación (QCM-D). Este método ha permitido evaluar la interacción de polímeros y nanopartículas con una capa de mucina. Los resultados obtenidos con el método desarrollado han permitido diseñar sistemas de nanopartículas con un mayor potencial de permeación a través de la mucosa. Esta técnica de alta sensibilidad también ha ofrecido la posibilidad de evaluar las dos propiedades opuestas, el conocimiento de las cuales es necesario para un correcto diseño de sistemas cpaços de cruzar la mucosa: mucoadhesió vs mucopenetració. Los Poly (β-amino ester)s (PBAEs) se han propuesto como sistemas biodegradables capaces de formar nanopartículas, por complejación con ADN, que presentan una elevada capacidad de transfección. Sin embargo, muestran problemas de estabilidad en condiciones fisiológicas y son incapaces de atravesar la capa de mucosa. En esta tesis se describe una nueva solución en la preparación de las formulaciones de los nanocomplejos basada en la utilización de recubrimientos que estabilizan las nanopartículas y aumentan su permeabilidad. Los recubrimeintos propuestos inclutyen: i) azúcares (sucrosa, trhalosa y manitol), ii) quitosano sin modificar de 22 KDa y con 60-120 kDa, iii) quitosano modificado con ácido tioglicólico y iv) ácido poliacrílico-bromelaina. Todas las nuevas formulaciones se han evaluado con diferentes cantidades de recubrimiento. Se han determinado sus propiedades fisicoquímicas y su eficacia de transfección y citotoxicidad frente a células COS-7. Se ha estudiado La difusión de las partículas a través de la mucosa gástrica de cerdo utilizando diferentes técnicas como el tubo rotatorio de silicona o el múltiple particle tracking (MPT). Los resultados obtenidos han mostrado superior estabilidad, eficacia de transfección y permeabilidad sobre la mucosa de las nuevas formulaciones diseñadas.
Mucus penetrating nanoparticle-based delivery systems of macromolecular drugs are currently receiving increasing attention in both academic and industrial research. Synthetic delivery systems provide highly suitable and tunable platform for the delivery of the macromolecules. However, a highly viscoelastic and adhesive mucus layer generally traps and rapidly removes most foreign substance from the mucosal surfaces, thereby limiting effectiveness of these nanocarriers. This Thesis is addressed to the development of engineering DNA delivery systems capable of high stability and transfection efficiency with low toxicity, and quickly crossing the mucus layer. Moreover, this Thesis is focused on design and development of methods and techniques in vitro in order to select more efficient delivery systems. A simple and efficient method, based on the use of the quartz crystal microbalance with dissipation (QCM-D) technique, is developed and evaluated the interaction of the polymers and nanoparticles with the mucin layer, resulting in the development of nanoparticle-based delivery systems to mucosal tissue. This highly sensitive technique also offers to evaluate the two opposing properties, needed for the design of efficient mucous permeation systems: mucoadhesion vs mucus penetration. Poly(β-amino ester)s (PBAEs) are currently considered of great interest as biodegradable polymeric carriers of DNA delivery, but they present limited stability in physiological conditions and the inability to penetrate the mucus layer. In this Thesis, we describe a novel surface-modified formulation of DNA delivery systems consisting of PBAE/DNA complexes and the coating agents, including: i) sugars (sucrose, trehalose or mannitol), ii) unmodified chitosan with a 22 kDa (CS) and a with a 60-120 kDa (CSM), iii) chitosan-thioglycolic acid (CS-TGA), and iv) poly(acrylic acid)-bromelain (PAA-BRO) conjugates. All novel formulations formed with different amounts of the coating agents are evaluated the physicochemical properties. The influence of coating agents on transfection efficiency and cytotoxicity is evaluated in COS-7 cells. Particle diffusion through porcine intestinal mucus (PImucus) is assessed by either rotating silicone tube technique or multiple particle tracking (MPT). The results highlight the superior stability, transfection efficiency and mucus permeability of the novel nanoparticle-based drug delivery systems. The effect of the amount of coating agents is also discussed.
Dua, Pinky. "Model based and parametric control for drug delivery systems." Thesis, Imperial College London, 2005. http://hdl.handle.net/10044/1/8040.
Full textDixon, John Robert. "Examining the impacts of Web-based education delivery systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58335.pdf.
Full textSchultze, Jennifer [Verfasser]. "Polymer-Based Systems for Drug Delivery Studies / Jennifer Schultze." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1186179627/34.
Full textElahrash, K. S. "Some physical studies with polymer based drug delivery systems." Thesis, University of Brighton, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354875.
Full textMohd, Azmi Mohd Azraie Bin. "Integrated silicon nanowire biosensor and MEMS based delivery systems." Thesis, Swansea University, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678641.
Full textAbodinar, Atiga Emhemed. "Construction of potential drug delivery systems based on polysaccharides." Thesis, University of Huddersfield, 2016. http://eprints.hud.ac.uk/id/eprint/32608/.
Full textTang, Qiong. "Multifunctional Natural Material-based Delivery Systems for Gene Therapy." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1415382826.
Full textChen, Ming [Verfasser], Alfred [Akademischer Betreuer] Fahr, and Gerrit L. [Akademischer Betreuer] Scherphof. "Skin Drug Delivery From Different Lipid Vesicular Systems / Ming Chen. Gutachter: Alfred Fahr ; Gerrit L. Scherphof." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2011. http://d-nb.info/1017078890/34.
Full textGrove, Mette. "Development and characterisation of lipid-based formulations for oral delivery of poorly soluble drug substances /." Cph. : The Danish University of Pharmaceutical Sciences, Department of Pharmaceutics and Analytical Chemistry, 2006. http://www.dfuni.dk/index.php/Mette_Grove/3071/0/.
Full textBethune, Claudette R. "The role of drug-lipid interactions in biodistribution and therapeutic effects for drugs incorporated into liposomes /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/7954.
Full textBooth, Ronald L. "An Information Systems Project Delivery Methodology for Implementing Web-Based Program Management Systems." NSUWorks, 2003. http://nsuworks.nova.edu/gscis_etd/420.
Full textStasko, Nathan Allan Schoenfisch Mark H. "Synthesis and characterization of dendrimer-based nitric oxide delivery systems." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1421.
Full textTitle from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry.
Mistry, Ajay Ramanlal. "Development of non-viral gene delivery systems based on HMG1." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368705.
Full textBergin, Paul Michael. "Approaches to functionalised amine-based ligands for radiopharmaceutical delivery systems." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409852.
Full textIemsam-Arng, J. "Poly(ethylene) glycol based delivery systems for nucleic acid therapies." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1381001/.
Full textCulcuoglu, Mustafa U. "Reengineering Community Based Chronic Care Delivery Systems: Theory and Applications." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1627573050496332.
Full textOladiran, Gbolahan S. "Development and formulation of wax-based transdermal drug delivery systems." Thesis, Aston University, 2008. http://publications.aston.ac.uk/11060/.
Full textNolan, Christine Marie. "Microgel Based Materials for Controlled Macromolecule Delivery." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6874.
Full textScally, David James. "Novel polyethylene glycol based drug delivery systems : a calorimetric and QASAR based study." Thesis, University of Kent, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282425.
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