Relevant bibliographies by topics / Lipid based delivery systems

Academic literature on the topic 'Lipid based delivery systems'

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Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Lipid based delivery systems"

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Shrestha, Hina, Rajni Bala, and Sandeep Arora. "Lipid-Based Drug Delivery Systems." Journal of Pharmaceutics 2014 (May 19, 2014): 1–10. http://dx.doi.org/10.1155/2014/801820.

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The principle objective of formulation of lipid-based drugs is to enhance their bioavailability. The use of lipids in drug delivery is no more a new trend now but is still the promising concept. Lipid-based drug delivery systems (LBDDS) are one of the emerging technologies designed to address challenges like the solubility and bioavailability of poorly water-soluble drugs. Lipid-based formulations can be tailored to meet a wide range of product requirements dictated by disease indication, route of administration, cost consideration, product stability, toxicity, and efficacy. These formulations are also a commercially viable strategy to formulate pharmaceuticals, for topical, oral, pulmonary, or parenteral delivery. In addition, lipid-based formulations have been shown to reduce the toxicity of various drugs by changing the biodistribution of the drug away from sensitive organs. However, the number of applications for lipid-based formulations has expanded as the nature and type of active drugs under investigation have become more varied. This paper mainly focuses on novel lipid-based formulations, namely, emulsions, vesicular systems, and lipid particulate systems and their subcategories as well as on their prominent applications in pharmaceutical drug delivery.
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Baca-Estrada, M. E., M. Foldvari, S. L. Babiuk, and L. A. Babiuk. "Vaccine delivery: lipid-based delivery systems." Journal of Biotechnology 83, no. 1-2 (September 2000): 91–104. http://dx.doi.org/10.1016/s0168-1656(00)00313-8.

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DONG, Wen-Juan, Yin-Jian ZHOU, and Wei LIANG. "Lipid-based siRNA Delivery Systems." PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 39, no. 5 (July 24, 2012): 396–401. http://dx.doi.org/10.3724/sp.j.1206.2012.00190.

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Park, Joo Yeon, Mi-Gyeong Kim, Gayong Shim, and Yu-Kyoung Oh. "Lipid-based antigen delivery systems." Journal of Pharmaceutical Investigation 46, no. 4 (April 18, 2016): 295–304. http://dx.doi.org/10.1007/s40005-016-0246-z.

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Limongi, Tania, Francesca Susa, Monica Marini, Marco Allione, Bruno Torre, Roberto Pisano, and Enzo di Fabrizio. "Lipid-Based Nanovesicular Drug Delivery Systems." Nanomaterials 11, no. 12 (December 14, 2021): 3391. http://dx.doi.org/10.3390/nano11123391.

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In designing a new drug, considering the preferred route of administration, various requirements must be fulfilled. Active molecules pharmacokinetics should be reliable with a valuable drug profile as well as well-tolerated. Over the past 20 years, nanotechnologies have provided alternative and complementary solutions to those of an exclusively pharmaceutical chemical nature since scientists and clinicians invested in the optimization of materials and methods capable of regulating effective drug delivery at the nanometer scale. Among the many drug delivery carriers, lipid nano vesicular ones successfully support clinical candidates approaching such problems as insolubility, biodegradation, and difficulty in overcoming the skin and biological barriers such as the blood–brain one. In this review, the authors discussed the structure, the biochemical composition, and the drug delivery applications of lipid nanovesicular carriers, namely, niosomes, proniosomes, ethosomes, transferosomes, pharmacosomes, ufasomes, phytosomes, catanionic vesicles, and extracellular vesicles.
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Midoux, Patrick, and Chantal Pichon. "Lipid-based mRNA vaccine delivery systems." Expert Review of Vaccines 14, no. 2 (December 26, 2014): 221–34. http://dx.doi.org/10.1586/14760584.2015.986104.

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Jain, Shikha, Vikas Jain, and S. C. Mahajan. "Lipid Based Vesicular Drug Delivery Systems." Advances in Pharmaceutics 2014 (September 2, 2014): 1–12. http://dx.doi.org/10.1155/2014/574673.

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Vesicular drug delivery system can be defined as highly ordered assemblies consisting of one or more concentric bilayers formed as a result of self-assembling of amphiphilic building blocks in presence of water. Vesicular drug delivery systems are particularly important for targeted delivery of drugs because of their ability to localize the activity of drug at the site or organ of action thereby lowering its concentration at the other sites in body. Vesicular drug delivery system sustains drug action at a predetermined rate, relatively constant (zero order kinetics), efficient drug level in the body, and simultaneously minimizes the undesirable side effects. It can also localize drug action in the diseased tissue or organ by targeted drug delivery using carriers or chemical derivatization. Different types of pharmaceutical carriers such as polymeric micelles, particulate systems, and macro- and micromolecules are presented in the form of novel drug delivery system for targeted delivery of drugs. Particulate type carrier also known as colloidal carrier system, includes lipid particles, micro- and nanoparticles, micro- and nanospheres, polymeric micelles and vesicular systems like liposomes, sphingosomes, niosomes, transfersomes, aquasomes, ufasomes, and so forth.
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Kotta, Sabna, Navneet Sharma, Prateek Raturi, Mohd Aleem, and Rakesh Kumar Sharma. "Exploring Novel Strategies for Lipid-Based Drug Delivery." Journal of Nanotoxicology and Nanomedicine 3, no. 1 (January 2018): 1–22. http://dx.doi.org/10.4018/jnn.2018010101.

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Currently, the concept of lipid-based drug delivery systems has gained much interest because of their capability to deliver drugs which dissolve sparingly in water or insoluble in nature. Several methods of lipid-based drug delivery exist, and each method has its own advantages as well as limitations. The primary objective of the formulation development is to improve the bioavailability of the drug. The nano-sized lipid-based drug delivery systems have enough potential to do so. This article addresses the various barriers to the transportation of drugs through certain routes and also the common excipients which used to develop the lipid-based drug delivery systems. It provides a thorough overview of the lipid formulation classification scheme (LFCS) and also deals with several formulation & evaluation aspects of lipid-based drug delivery system. Further, it focuses on the formulations which are already available in the market and their regulatory concerns, respectively.
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Chime, Salome A., Paul A. Akpa, and Anthony A. Attama. "The Utility of Lipids as Nanocarriers and Suitable Vehicle in Pharmaceutical Drug Delivery." Current Nanomaterials 4, no. 3 (November 11, 2019): 160–75. http://dx.doi.org/10.2174/2405461504666191016091827.

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Lipid based excipients have gained popularity recently in the formulation of drugs in order to improve their pharmacokinetic profiles. For drugs belonging to the Biopharmaceutics Classification System (BCS) class II and IV, lipid excipients play vital roles in improving their pharmacokinetics properties. Various nanocarriers viz: Solid lipid nanoparticles, nanostructured lipid carriers, selfnanoemulsifying drug delivery systems (SNEDDS), nanoliposomes and liquid crystal nanoparticles have been employed as delivery systems for such drugs with evident successes. Lipid-based nanotechnology have been used to control the release of drugs and have utility for drug targeting and hence, have been used for the delivery of various anticancer drugs and for colon targeting. Drugs encapsulated in lipids have enhanced stability due to the protection they enjoy in the lipid core of these nanoformulations. However, lipid excipients could be influenced by factors which could affect the physicochemical properties of lipid-based drug delivery systems (LBDDS). These factors include the liquid crystalline phase transition, lipid crystallization and polymorphism amongst others. However, some of the physicochemical properties of lipids made them useful as nanocarriers in the formulation of various nanoformulations. Lipids form vesicles of bilayer which have been used to deliver drugs and are often referred to as liposomes and nanoliposomes. This work aims at reviewing the different classes of lipid excipients used in formulating LBDDS and nanoformulations. Also, some factors that influence the properties of lipids, different polymorphic forms in lipid excipients that made them effective nanocarriers in nano-drug delivery would be discussed. Special considerations in selecting lipid excipients used in formulating various forms of nanoformulations would be discussed.
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Dahiya, Sunita, and Rajiv Dahiya. "BIOAVAILABILITY ENHANCEMENT AND LIPID NANOCARRIER BASED DELIVERY OF PEPTIDES AND PROTEINS." Bulletin of Pharmaceutical Research 10, no. 1-3 (2020): 1–10. http://dx.doi.org/10.21276/bpr.2020.10.3.

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Peptides and proteins are vital biomacromolecules that perform several bodily functions in various physiological and biological processes. Being biocompatible and biodegradable, these macromolecules are considered promising platforms for delivery of drugs and genes. However, peptides and proteins suffer from major limitations including enzymatic degradation, short circulation half-lives, and poor membrane permeability that leads to poor bioavailability, challenging their effective delivery. This article briefly discusses the inherent challenges in peptide and protein delivery along with strategies for bioavailability enhancement and lipid nanocarriers as prospective systems for peptide and protein drug delivery.
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Dissertations / Theses on the topic "Lipid based delivery systems"

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Mok, Kenneth W. C. "Characterization of lipid-based DNA delivery systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ34590.pdf.

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Jørgensen, Lene. "Lipid based drug delivery systems for parenteral delivery of proteins /." Cph. : Department of Pharmaceutics, the Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/lenejoergensen.htm.

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Brinkmann, Joscha [Verfasser]. "Thermodynamics of Lipid-Based Drug Delivery Systems / Joscha Brinkmann." München : Verlag Dr. Hut, 2021. http://d-nb.info/1238423043/34.

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Pan, Xiaogang. "Design and evaluation of lipid based delivery systems for delivery of small molecules and macro-molecular nucleotides based therapeutic agents." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164679618.

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Lam, Angela Man Iu. "Influence of calcium on the transfection properties of lipid-based gene delivery systems." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61130.pdf.

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Kleemann, Elke. "Polyethylenimine- and lipid-based nanoparticles as gene and drug delivery systems for aerosol therapy to the lung." [S.l.] : [s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0363/.

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Helena, (nee Slabbert) Chrizaan. "Formulation, characterization and cellular toxicity of lipid based drug delivery systems for mefloquin / Chrizaan Helena (nee Slabbert)." Thesis, North-West University, 2011. http://hdl.handle.net/10394/8433.

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Malaria affects millions of people annually especially in third world countries. Increase in resistance and limited research being conducted adds to the global burden of malaria. Mefloquine, known for unwanted adverse reactions and neurotoxicity, is highly lipophilic and is still used as treatment and prophylaxis. Lipid drug delivery systems are commonly used to increase solubility and efficacy and decrease toxicity. The most generally used lipid drug delivery system is liposomes. The lipid bilayer structure varying in size from 25 nm to 100 μm can entrap both hydrophilic and lipophilic compounds. Similar in structure and size to liposomes, Pheroid™ technology consist of natural fatty acids and is also able to entrap lipophilic and hydrophilic compounds. The aim of this study was to formulate liposomes and Pheroid™ vesicles loaded with mefloquine and evaluate the physiochemical characteristic of the formulations followed by efficacy and toxicity studies. Pheroid™ vesicles and liposomes with and without mefloquine were evaluated in size, morphology, pH and entrapment efficacy during three month accelerated stability testing. Optimization of size determination by flow cytometry lead to accurate determination of size for both Pheroid™ vesicles and liposomes. During the three months stability testing, Pheroid™ vesicles showed a small change in size from 3.07 ± 0.01 μm to approximately 3 μm for all three temperatures. Confocal laser scanning microscopic evaluation of the liposomes showed structures uniform in spherical shape and size. No difference in size or structure between the Pheroid™ vesicles with and without mefloquine were obtained. Significant increase (p=0.027) in size from 6.46 ± 0.01 μm to above 10 μm was observed for liposomes at all the temperatures. Clearly formed lipid bilayer structures were observed on micrographs. With the addition of mefloquine to the liposome formulation, a decrease in the amount of bilayer structures and an increase in oil droplets were found. Entrapment efficacy was determined by firstly separating the entrapped drug from the unentrapped drug utilizing a Sephadex®G50 mini column. This was followed by spectrophotometric evaluation by UV-spectrophotometry at 283 nm. Initial entrapment efficacy of both Pheroid™ vesicles and liposomes was above 60%. An increase in entrapment efficacy was observed for Pheroid™ vesicles. The addition of mefloquine to already formulated Pheroid™ vesicles illustrated entrapment efficacy of 60.14 ± 5.59% after 14 days. Formulations loaded with mefloquine resulted in lower pH values as well as a decrease in pH over time. Optimization of efficacy studies utilizing propidium iodide was necessary due to the similarity in size and shape of the drug delivery systems to erythrocytes. A gating strategy was successfully implemented for the determination of the percentage parasitemia. Efficacy testing of mefloquine loaded in Pheroid™ vesicles and liposomes showed a 186% and 207% decrease in parasitemia levels compared to the control of mefloquine. Toxicity studies conducted include haemolysis and ROS (reactive oxygen species) analysis on erythrocytes as well as cell viability on mouse neuroblastoma cells. Pheroid™ vesicles with and without mefloquine resulted in a dose dependent increase in ROS and haemolysis over time. A dose dependent increase in ROS and haemolysis in both liposome formulations were observed, but to a lesser extent. Mefloquine proved to be neurotoxic with similar results obtained when mefloquine was entrapped in liposomes. Pheroid™ vesicles seem to have neuroprotective properties resulting in higher cell viability. Mefloquine could be entrapped successfully in Pheroid™ vesicles and less in liposomes. Pheroid™ vesicles was more stable over a three months accelerated stability testing with more favourable characteristics. The increase in ROS levels of Pheroid™ vesicles could be responsible for the higher efficacy and haemolytic activity. DL-α-Tocopherol in Pheroid™ vesicles possibly acted as a pro-oxidant due to the presence of iron in the erythrocytes. DL-α-Tocopherol showed possible antioxidant properties in the neurotoxicity evaluation resulting in higher cell viability. Even though liposomes illustrated higher efficacy and little haemolysis and ROS production, no difference in neurotoxicity was observed together with unfavourable properties during stability testing makes this drug delivery system less favourable in comparison to Pheroid™ vesicles. Mefloquine was successfully incorporated into Pheroid™ vesicles resulted in high efficacy and showed possible neuroprotection and therefore makes it an ideal system for treatment of malaria.
Thesis (Ph.D. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2011
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Jarzębińska, Anita [Verfasser], and Ernst [Akademischer Betreuer] Wagner. "Lipid-based delivery system for chemically modified mRNA / Anita Jarzębińska ; Betreuer: Ernst Wagner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1136270884/34.

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Brody, Leigh. "Design, synthesis and biological evaluation of novel lipid-based nanoparticle delivery system for metabolic re-engineering." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14406.

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Dietary supplementation with fibre has been shown to ameliorate features of the metabolic syndrome and inhibit malignant growth in certain types of cancer. These effects have been linked to short-chain fatty acids (SCFA), mostly acetate. However, the ubiquitous role of SCFAs in metabolism, combined with a short tissue half-life and the non-targeted nature of oral and peripheral administrations make achieving phenotypically relevant levels of SCFA by standard delivery techniques challenging and limit their therapeutic potential. Liposomal encapsulation of a therapeutic agent overcomes these issues by protecting against degradation, increasing circulation time and passively targeting both the liver and tumour tissue. In this research project, I have designed a bifunctional liposome formulation to transport SCFA, monitored their distribution and uptake utilising visualisation by MRI, PET/CT and fluorescence microscopy. These bifunctional liposomes were useful for effectively encapsulating small molecules within their aqueous core, which in this case was acetate, and capable of acetate delivery into cells while also being amenable to cellular imaging. I have shown that preferential delivery of liposome encapsulated acetate (LITA) nanoparticles to key sites of metabolic control provide beneficial therapeutic effects in animal models of both obesity and cancer. Chronic administration of LITA nanoparticles in an obeseogenic model led to a significant reduction in adiposity, intrahepatocellular lipid, inflammatory tone and genetic indication of a decrease fatty acid synthesis in the liver. Application of LITA in a murine xenograft model caused an inhibition of tumour growth in three colorectal cancer cell lines: HT-29, HCT116 p53+/+ and HCT116 p53-/-. The mechanisms for these two outcomes are not fully defined; however cellular energy homeostasis of both scenarios was restored. These results indicate that LITA nanoparticles can be used to improve multiple metabolic pathways, in vivo.
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Schwab, Martin. "Degradation of lipid based drug delivery systems and characterization of semi-synthetic spider silk proteins for the application in pharmaceutical technology." Diss., Ludwig-Maximilians-Universität München, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-165238.

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Books on the topic "Lipid based delivery systems"

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T, Nylander, and Lindman Björn 1942-, eds. Lipids and polymer-lipid systems. Berlin: Springer, 2002.

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Bari, Elia, Sara Perteghella, and Maria Luisa Torre, eds. Silk-based Drug Delivery Systems. Cambridge: Royal Society of Chemistry, 2020. http://dx.doi.org/10.1039/9781839162664.

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Cheng, Yiyun, ed. Dendrimer-Based Drug Delivery Systems. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118275238.

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Lu, Wan-Liang, and Xian-Rong Qi, eds. Liposome-Based Drug Delivery Systems. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-49231-4.

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1956-, Svenson Sönke, American Chemical Society. Division of Colloid and Surface Chemistry, and American Chemical Society Meeting, eds. Carrier-based drug delivery. Washington, D.C: American Chemical Society, 2004.

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Nayak, Amit Kumar, Md Saquib Hasnain, and Dilipkumar Pal, eds. Ionically Gelled Biopolysaccharide Based Systems in Drug Delivery. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-2271-7.

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Desai, Murli. Rights-based Integrated Child Protection Service Delivery Systems. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-13-8534-6.

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Dendrimer-based drug delivery systems: From theory to practice. Hoboken, N.J: John Wiley & Sons, 2012.

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Roohinejad, Shahin, Ralf Greiner, Indrawati Oey, and Jingyuan Wen, eds. Emulsion-based Systems for Delivery of Food Active Compounds. Chichester, UK: John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119247159.

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Matsumura, Yasuhiro, and David Tarin, eds. Cancer Drug Delivery Systems Based on the Tumor Microenvironment. Tokyo: Springer Japan, 2019. http://dx.doi.org/10.1007/978-4-431-56880-3.

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Book chapters on the topic "Lipid based delivery systems"

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Liu, Yang, and Leaf Huang. "Lipid-Coated Cisplatin Nanoparticles for Insoluble Drug Loading." In Liposome-Based Drug Delivery Systems, 1–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49231-4_7-1.

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Fu, Yao. "Co-delivery of Anticancer Therapeutics via Lipid-Based Nanoscale Delivery Systems." In Functional Lipid Nanosystems in Cancer, 189–230. New York: Jenny Stanford Publishing, 2021. http://dx.doi.org/10.1201/9781003056997-8.

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Wen, Jingyuan, Shuo Chen, and Guanyu Chen. "Solid Lipid Nanoparticles." In Emulsion-based Systems for Delivery of Food Active Compounds, 121–38. Chichester, UK: John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119247159.ch5.

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Wen, Jingyuan, Guanyu Chen, and Shuo Chen. "Nanostructured Lipid Carriers." In Emulsion-based Systems for Delivery of Food Active Compounds, 139–59. Chichester, UK: John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119247159.ch6.

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Jitta, Srinivas Reddy, and Lalit Kumar. "Solid Lipid Nanoparticles-Based Drug and Gene Delivery to Macrophages." In Macrophage Targeted Delivery Systems, 203–24. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-84164-5_10.

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Cortesi, Rita, Paolo Mariani, Markus Drechsler, and Elisabetta Esposito. "Lipid-Based Nanoparticles: SLN, NLC, and MAD." In Novel Drug Delivery Systems for Phytoconstituents, 81–102. Boca Raton : Taylor & Francis, 2020. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: CRC Press, 2019. http://dx.doi.org/10.1201/9781351057639-5.

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Dragićević, Nina. "Lipid-Based Vesicles (Liposomes) as Skin Delivery Systems." In Invasomes as Drug Nanocarriers for Innovative Pharmaceutical Dosage Forms, 31–108. Boca Raton: CRC Press, 2021. http://dx.doi.org/10.1201/9781003187332-2.

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Clemente, Ilaria, Ilaria Colzi, and Sara Falsini. "Lipid-Based Nanoformulations from Plants for Sustainable Drug Delivery." In Novel Drug Delivery Systems for Phytoconstituents, 301–12. Boca Raton : Taylor & Francis, 2020. | “A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc.”: CRC Press, 2019. http://dx.doi.org/10.1201/9781351057639-15.

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Chen, David, and Sara Yazdi. "Polymer- and Lipid-Based Systems for Parenteral Drug Delivery." In Sterile Product Development, 47–60. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7978-9_3.

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Penchala, Sravan, Anh-Nhan Pham, Ying Huang, and Jeffrey Wang. "Lipid-Based and Self-Emulsifying Oral Drug Delivery Systems." In Oral Bioavailability, 343–54. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118067598.ch21.

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Conference papers on the topic "Lipid based delivery systems"

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Léber, Attila, Erzsébet Csányi, and Mária Budai-Szűcs. "Lipid-based delivery systems for periodontitis treatment." In I. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Szeged: Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2019. http://dx.doi.org/10.14232/syrptbrs.2019.op16.

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Paula, Eneida de. "LIPID-BASED (LIPOSOMES, NANOSTRUCTURED LIPID CARRIERS) DELIVERY SYSTEMS FOR LOCAL ANESTHETICS." In Encontro Anual da Biofísica 2018. São Paulo: Editora Blucher, 2018. http://dx.doi.org/10.5151/biofisica2018-42.

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Bahadori, Fatemeh, Aydan Dag, Evrim Kepekçi, Gulacti Topcu, Ayse Karatug, Sehnaz Bolkent, and Hayat Onyuksel. "Comparison of Efficacy and Toxicity of Lipid Based and Polymeric Nano Drug Delivery Systems." In Annual International Conference on Advances in Biotechnology. Global Science & Technology Forum (GSTF), 2014. http://dx.doi.org/10.5176/2251-2489_biotech14.48.

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Osaki, Toshihisa, and Shoji Takeuchi. "Dielectrophoresis-based liposome delivery to a planar lipid membrane for efficient membrane protein reconstitution." In 2010 IEEE 23rd International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2010. http://dx.doi.org/10.1109/memsys.2010.5442360.

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Vitek, Mercedes, Mirjam Gosenca Matjaž, Mirjana Gašperlin, Robert Roškar, and Alenka Zvonar Pobirk. "Antioxidant efficacy of vitamins loaded lipid based delivery systems with different microstructure for dermal application." In III. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Szeged: Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2021. http://dx.doi.org/10.14232/syrptbrs.2021.op34.

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Tomas, Mabel, Claudia Copado, Luciana Julio, and Vanesa Ixtaina. "Strategies for protecting functional components of chia oil by emulsion-based delivery systems with sunflower lecithin." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/dxsl3212.

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Chia seed oil represents an important vegetal source of ω-3 polyunsaturated fatty acids (PUFAs) being very susceptible to lipid oxidation. Emulsion-based delivery systems could constitute a tool for its protection and incorporation into foods. In this study chia bilayer O/W emulsions were obtained by layer-by-layer deposition technique (LBL). It consisted of the electrostatic deposition of positively charged chitosan on negatively charged oil droplets being stabilized with modified sunflower lecithins. The effect of pH of emulsions was also evaluated. The particle size distribution, mean diameters, ζ-potential and viscosity of emulsions were determined. The chitosan addition had a strong influence (p‰¤0.001) on the rheological properties increasing the viscosity and changing the flow behavior of emulsions. The global and oxidative stability of emulsions were evaluated during refrigerated storage. The bilayer emulsions showed better physical stability and lower peroxide values (p‰¤0.05) than the monolayer ones and bulk chia oil, and with no significant (p >0.05) changes in their ω-3 PUFAs content during the storage. Bilayer emulsions with modified sunflower lecithins proved to be protective systems against lipid oxidation, constituting a viable option for the delivery of chia ω-3PUFAs with potential application in the food industry
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Liu, Xuan, Zhaoxiong Wan, Yuanwei Zhang, and Yuwei Liu. "Optically computed phase microscopy to assess cellular uptake of lipid nanoparticles." In CLEO: Applications and Technology. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/cleo_at.2022.atu5i.6.

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We developed a novel optically computed phase microscopy (OCPM) system, for depth-resolved phase imaging. We used OCPM to assess cellular uptake of lipid nanoparticles (LNPs), for the optimization of drug delivery systems based on LNPs.
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Tartis, Michaelann S., Jan Marik, Azadeh Kheirolomoom, Rachel E. Pollard, Hua Zhang, Jinyi Qi, Julie L. Sutcliffe, and Katherine W. Ferrara. "Pharmacokinetics of Encapsulated Paclitaxel: Multi-Probe Analysis With PET." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176435.

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We have combined two imaging probes and used PET as a means to provide image-based validation for a novel targeted drug delivery system. The first probe was a direct labeling of the drug [18F]fluoropaclitaxel [1–3], which was inserted into various carrier vehicle formulations. The second probe, [18F]fluoro-1,2-dipalmitoyl-sn-glycerol, i.e. [18F]FDP involved radiolabeling the lipid vehicle. Paclitaxel, which is poorly soluble in aqueous media, also has limited solubility and stability in lipophilic environments such as liposomes. Stable association of paclitaxel with the lipid bilayer is affected by a variety of physicochemical factors such as temperature and liposome composition. Paclitaxel crystal formation has been documented, with two forms of solid state within aqueous media and organic solvents, although crystal conformation differs in each media [4,5]. We provide dynamic in vivo image sets providing biodistribution and time activity curves of free [18F]fluoropaclitaxel and liposomal [18F]fluoropaclitaxel as well as free [18F]FDP, liposomal [18F]FDP, and [18F]FDP in an ultrasound contrast agent. Serial studies were performed within a small group of rats, minimizing inter-animal variability. The two labeled molecules have different biodistributions: paclitaxel is rapidly taken up in the liver, intestines and kidneys, while the labeled lipid incorporated into liposomes stays in circulation with minimal uptake in organs other than spleen. Here, we have developed a quantitative method to follow paclitaxel and lipid vehicles to their destination in vivo in order to improve targeted paclitaxel delivery.
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Maktabi, Sepehr, Jeffrey W. Schertzer, and Paul R. Chiarot. "Microfluidic-Based Fabrication and Dielectrophoretic Manipulation of Microcapsules." In ASME 2019 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/imece2019-11903.

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Abstract To probe the complexity of biological systems, large numbers of independent experiments are needed to gather statistically reliable information. A platform that performs these experiments at high-throughput demands precise control over the formation and delivery of microcapsules. Microfluidics enables passive and active modes of droplet formation, manipulation, and mixing. Aqueous- and organic-based emulsions serve as well-defined compartments that encapsulate target materials (e.g., cells, reagents, nucleic acid, and nanoparticles) in femto- to picoliter volumes surrounded by an immiscible fluid. In this work, we demonstrate a high-throughput PDMS-based microfluidic device for fabrication and control of uniform micron-size water-in-oil and oil-in-water emulsions. Passive and active modes of droplet generation (i.e., hydrodynamic flow focusing and electrospray, respectively) are utilized to form droplets in the size range of 1 to 100 μm. We also leverage dielectrophoretic forces to steer the microemulsions across flows of organic or inorganic phases. The dielectrophoretic force provides high-speed separation with no moving elements and does not require droplet charging. Two electrode designs of AC- and DC-based circuits incorporated into the PDMS block are proposed. We investigate the effect of frequency and voltage on the degree of deflection and separation efficiency of the emulsions. We show that the fabricated microcapsules can be used as templates to build synthetic lipid bilayer model membranes that more accurately mimic physiological conditions. In addition, our microfluidic-based device integrated with on-board electronics can be used as an essential component in high-speed screening bioassays.
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Tucak, Amina, Merima Sirbubalo, Edina Vranić, and Andreas Zimmer. "Solid Lipid Nanoparticles as Drug Delivery Systems for MicroRNA." In III. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Szeged: Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2021. http://dx.doi.org/10.14232/syrptbrs.2021.op23.

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Reports on the topic "Lipid based delivery systems"

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Sampson, James, Jill Lumsden, Darrin Carr, and Elisa Rudd. A Differential Feature-Cost Analysis of Internet-Based Career Information Delivery Systems (CIDS). Florida State University Libraries, December 1999. http://dx.doi.org/10.17125/fsu.1525966258.

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Popova, Teodora, Borislav Tzankov, Christina Voycheva, Krassimira Yoncheva, and Nikolai Lambov. Development of Advanced Drug Delivery Systems with Bicalutamide Based on Mesoporous Silica Particles. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, December 2019. http://dx.doi.org/10.7546/crabs.2019.12.08.

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Sampson, James. Current Status and Future Potential for Evaluating the Design and Use of Computer-Based Career Information Delivery Systems in the United States. Florida State University Libraries, December 1993. http://dx.doi.org/10.17125/fsu.1525960033.

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Zamorano, Natalia, and Cristian Herrera. Can community-based intervention packages reduce maternal and neonatal morbidity and mortality? SUPPORT, 2017. http://dx.doi.org/10.30846/170115.

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In the last three decades, rates of neonatal mortality in low-income countries have declined much more slowly than the rates of infant and maternal mortality. A significant proportion of these deaths could potentially be addressed by community-based intervention packages, which are defined as delivering more than one intervention via different sets of strategies that include additional training of outreach workers, building community-support, community mobilization, antenatal and postnatal home visitation, training of traditional birth attendants, antenatal and delivery home visitation, and home-based neonatal care and treatment; usually supplemented by strengthening linkages with local health systems.
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Cook, Stephen, and Loyd Hook. Developmental Pillars of Increased Autonomy for Aircraft Systems. ASTM International, January 2020. http://dx.doi.org/10.1520/tr2-eb.

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Increased automation for aircraft systems holds the promise to increase safety, precision, and availability for manned and unmanned aircraft. Specifically, established aviation segments, such as general aviation and light sport, could utilize increased automation to make significant progress towards solving safety and piloting difficulties that have plagued them for some time. Further, many emerging market segments, such as urban air mobility and small unmanned (e.g., small parcel delivery with drones) have a strong financial incentive to develop increased automation to relieve the pilot workload, and/or replace in-the-loop pilots for most situations. Before these advances can safely be made, automation technology must be shown to be reliable, available, accurate, and correct within acceptable limits based on the level of risk these functions may create. However since inclusion of these types of systems is largely unprecedented at this level of aviation, what constitutes these required traits (and at what level they must be proven to) requires development as well. Progress in this domain will likely be captured and disseminated in the form of best practices and technical standards created with collaboration from regulatory and industry groups. This work intends to inform those standards producers, along with the system designers, with the goal of facilitating growth in aviation systems toward safe, methodical, and robust inclusion of these new technologies. Produced by members of the manned and unmanned small aircraft community, represented by ASTM task group AC 377, this work strives to suggest and describe certain fundamental principles, or “pillars”, of complex aviation systems development, which are applicable to the design and architectural development of increased automation for aviation systems.
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Phuong, Vu Tan, Nguyen Van Truong, and Do Trong Hoan. Commune-level institutional arrangements and monitoring framework for integrated tree-based landscape management. World Agroforestry, 2021. http://dx.doi.org/10.5716/wp21024.pdf.

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Governance is a difficult task in the context of achieving landscape multifunctionality owing to the multiplicity of stakeholders, institutions, scale and ecosystem services: the ‘many-multiple’ (Cockburn et al 2018). Governing and managing the physical landscape and the actors in the landscape requires intensive knowledge and good planning systems. Land-use planning is a powerful instrument in landscape governance because it directly guides how actors will intervene in the physical landscape (land use) to gain commonly desired value. It is essential for sustaining rural landscapes and improving the livelihoods of rural communities (Bourgoin and Castella 2011, Bourgoin et al 2012, Rydin 1998), ensuring landscape multifunctionality (Nelson et al 2009, Reyers et al 2012) and enhancing efficiency in carbon sequestration, in particular (Bourgoin et al 2013, Cathcart et al 2007). It is also considered critical to the successful implementation of land-based climate mitigation, such as under Nationally Determined Contributions (NDCs), because the Land Use, Land-Use Change and Forestry (LULUCF) sector is included in the mitigation contributions of nearly 90 percent of countries in Sub-Saharan and Southern Asia countries and in the Latin American and Caribbean regions (FAO 2016). Viet Nam has been implementing its NDC, which includes forestry and land-based mitigation options under the LULUCF sector. The contribution of the sector to committed national emission reduction is significant and cost-effective compared with other sectors. In addition to achieving emission reduction targets, implementation of forestry and land-based mitigation options has the highest benefits for social-economic development and achieving the Sustainable Development Goals (MONRE 2020). Challenges, however, lie in the way national priorities and targets are translated into sub-national delivery plans and the way sub-national actors are brought together in orchestration (Hsu et al 2019) in a context where the legal framework for climate-change mitigation is elaborated at national rather than sub-national levels and coordination between government bodies and among stakeholders is generally ineffective (UNDP 2018). In many developing countries, conventional ‘top–down’, centralized land-use planning approaches have been widely practised, with very little success, a result of a lack of flexibility in adapting local peculiarities (Amler et al 1999, Ducourtieux et al 2005, Kauzeni et al 1993). In forest–agriculture mosaic landscapes, the fundamental question is how land-use planning can best conserve forest and agricultural land, both as sources of economic income and environmental services (O’Farrell and Anderson 2010). This paper provides guidance on monitoring integrated tree-based landscape management at commune level, based on the current legal framework related to natural resource management (land and forest) and the requirements of national green-growth development and assessment of land uses in two communes in Dien Bien and Son La provinces. The concept of integrated tree based landscape management in Viet Nam is still new and should be further developed for wider application across levels.
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Vlaicu, Razvan. Trust, Collaboration, and Policy Attitudes in the Public Sector. Inter-American Development Bank, May 2021. http://dx.doi.org/10.18235/0003280.

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This paper examines new data on public sector employees from 18 Latin American countries to shed light on the role of trust in the performance of government agencies. We developed an original survey taken during the first COVID-19 wave that includes randomized experiments with pandemic-related treatments. We document that individual-level trust in coworkers, other public employees, and citizens is positively related to performance-enhancing behaviors, such as cooperation and information-sharing, and policy attitudes, such as openness to technological innovations in public service delivery. Trust is more strongly linked to positive behaviors and attitudes in non-merit-based civil service systems. High-trust and low-trust respondents report different assessments of their main work constraints. Also, they draw different inferences and prefer different policy responses when exposed to data-based framing treatments about social distancing outcomes in their countries. Low-trust public employees are more likely to assign responsibility for a negative outcome to the government and to prefer stricter enforcement of social distancing.
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Piercy, Candice, Brandon Boyd, Emily Russ, and Kyle Runion. Systematic beneficial use of dredged sediments : matching sediment needs with dredging requirements. Engineer Research and Development Center (U.S.), September 2022. http://dx.doi.org/10.21079/11681/45443.

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This technical note (TN) will outline a framework to identify beneficial and cost-effective coastal beneficial use of dredged sediment (BUDS) projects. Creation of a BUDS framework that can be applied at scale will promote sustainable BUDS practices, facilitating the delivery of flood risk management, social, and environmental benefits while still fulfilling the US Army Corps of Engineers (USACE) navigation mission. This proactive forecasting approach uses multi-criteria decision analysis (MCDA) and optimization tools to balance tradeoffs between navigation dredging and BUDS goals over project-scale timespans. The proposed framework utilizes available tools to quantify ecological system evolution and current and future dredging needs to develop a systems-level approach to BUDS. Required data include current and future information on (1) existing and planned natural and created aquatic ecological systems, which may include natural and nature-based features (NNBFs), (2) dredging requirements and costs, and (3) aquatic system physical and environmental data.
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Palmer, Guy, Varda Shkap, Wendy Brown, and Thea Molad. Control of bovine anaplasmosis: cytokine enhancement of vaccine efficacy. United States Department of Agriculture, March 2007. http://dx.doi.org/10.32747/2007.7695879.bard.

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Anaplasmosis an arthropod-born disease of cattle caused by the rickettsia Anaplasma marginale and is an impediment to efficient production of healthy livestock in both Israel and the United States. Currently the only effective vaccines are derived from the blood of infected cattle. The risk of widespread transmission of both known and newly emergent pathogens has prevented licensure of live blood-based vaccines in the U.S. and is a major concern for their continued use in Israel. Consequently development of a safe, effective vaccine is a high priority. In this collaborative project we focused on two approaches to vaccine development. The first focused o n improving antigen delivery to livestock and specifically examined how DNA vaccines could be improved to enhance priming and expansion of the immune response. This research resulted in development and testing of two novel vaccine delivery systems--one that targeted antigen spread among dendritic cells (the key cell in priming immune responses and a follow-on construct that also specifically targeted antigen to the endosomal-lysosomal compartment the processing organelle within the dendritic cell that directs vaccine antigen to the MHC class ll-CD4* T cell priming pathway). The optimized construct targeting vaccine antigen to the dendritic cell MHC class II pathway was tested for ability to prime A. marginale specific immune responses in outbred cattle. The results demonstrated both statistically significant effects of priming with a single immunization, continued expansion of the primary immune response including development of high affinity lgG antibodies and rapid recall of the memory response following antigen challenge. This portion of the study represented a significant advance in vaccine delivery for livestock. Importantly the impact of these studies is not limited to A. marginale a s the targeting motifs are optimized for cattle and can be adapted to other cattle vaccinations by inserting a relevant pathogen-specific antigen. The second approach (which represented an addition to the project for which approval was requested as part of the first annual report) was a comparative approach between A . marginale and the Israel A . centrale vaccines train. This addition was requested as studies on Major Surface Protein( MSP)- 2 have shown that this antigen is highly antigenically variable and presented solely as a "static vaccine" antigen does not give cross-strain immunity. In contrast A. . centrale is an effective vaccine which Kimron Veterinary institute has used in the field in Israel for over 50 years. Taking advantage of this expertise, a broad comparison of wild type A. marginale and vaccine strain was initiated. These studies revealed three primary findings: i) use of the vaccine is associated with superinfection, but absence of clinical disease upon superinfection with A. marginale; ii) the A. centrale vaccine strain is not only less virulent but transmission in competent in Dermacentor spp. ticks; and iii) some but not all MSPs are conserved in basic orthologous structure but there are significant polymorphisms among the strains. These studies clearly indicated that there are statistically significant differences in biology (virulence and transmission) and provide a clear path for mapping of biology with the genomes. Based on these findings, we initiated complete genome sequencing of the Israel vaccine strain (although not currently funded by BARD) and plant to proceed with a comparative genomics approach using already sequenced wild-type A. marginale. These findings and ongoing collaborative research tie together filed vaccine experience with new genomic data, providing a new approach to vaccine development against a complex pathogen.
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Daudelin, Francois, Lina Taing, Lucy Chen, Claudia Abreu Lopes, Adeniyi Francis Fagbamigbe, and Hamid Mehmood. Mapping WASH-related disease risk: A review of risk concepts and methods. United Nations University Institute for Water, Environment and Health, December 2021. http://dx.doi.org/10.53328/uxuo4751.

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The report provides a review of how risk is conceived of, modelled, and mapped in studies of infectious water, sanitation, and hygiene (WASH) related diseases. It focuses on spatial epidemiology of cholera, malaria and dengue to offer recommendations for the field of WASH-related disease risk mapping. The report notes a lack of consensus on the definition of disease risk in the literature, which limits the interpretability of the resulting analyses and could affect the quality of the design and direction of public health interventions. In addition, existing risk frameworks that consider disease incidence separately from community vulnerability have conceptual overlap in their components and conflate the probability and severity of disease risk into a single component. The report identifies four methods used to develop risk maps, i) observational, ii) index-based, iii) associative modelling and iv) mechanistic modelling. Observational methods are limited by a lack of historical data sets and their assumption that historical outcomes are representative of current and future risks. The more general index-based methods offer a highly flexible approach based on observed and modelled risks and can be used for partially qualitative or difficult-to-measure indicators, such as socioeconomic vulnerability. For multidimensional risk measures, indices representing different dimensions can be aggregated to form a composite index or be considered jointly without aggregation. The latter approach can distinguish between different types of disease risk such as outbreaks of high frequency/low intensity and low frequency/high intensity. Associative models, including machine learning and artificial intelligence (AI), are commonly used to measure current risk, future risk (short-term for early warning systems) or risk in areas with low data availability, but concerns about bias, privacy, trust, and accountability in algorithms can limit their application. In addition, they typically do not account for gender and demographic variables that allow risk analyses for different vulnerable groups. As an alternative, mechanistic models can be used for similar purposes as well as to create spatial measures of disease transmission efficiency or to model risk outcomes from hypothetical scenarios. Mechanistic models, however, are limited by their inability to capture locally specific transmission dynamics. The report recommends that future WASH-related disease risk mapping research: - Conceptualise risk as a function of the probability and severity of a disease risk event. Probability and severity can be disaggregated into sub-components. For outbreak-prone diseases, probability can be represented by a likelihood component while severity can be disaggregated into transmission and sensitivity sub-components, where sensitivity represents factors affecting health and socioeconomic outcomes of infection. -Employ jointly considered unaggregated indices to map multidimensional risk. Individual indices representing multiple dimensions of risk should be developed using a range of methods to take advantage of their relative strengths. -Develop and apply collaborative approaches with public health officials, development organizations and relevant stakeholders to identify appropriate interventions and priority levels for different types of risk, while ensuring the needs and values of users are met in an ethical and socially responsible manner. -Enhance identification of vulnerable populations by further disaggregating risk estimates and accounting for demographic and behavioural variables and using novel data sources such as big data and citizen science. This review is the first to focus solely on WASH-related disease risk mapping and modelling. The recommendations can be used as a guide for developing spatial epidemiology models in tandem with public health officials and to help detect and develop tailored responses to WASH-related disease outbreaks that meet the needs of vulnerable populations. The report’s main target audience is modellers, public health authorities and partners responsible for co-designing and implementing multi-sectoral health interventions, with a particular emphasis on facilitating the integration of health and WASH services delivery contributing to Sustainable Development Goals (SDG) 3 (good health and well-being) and 6 (clean water and sanitation).
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