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Journal articles on the topic "Linked Iodine 125 seeds"
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JARUSEVICIUS, Laimonas, Arturas INCIURA, Elona JUOZAITYTE, Kestutis VAICIUNAS, Antanas VAITKUS, and Migle SNIUREVICIUTE. "Comparison of Implant Quality between Loose and Intra-operatively Linked Iodine-125 Seeds in Prostate Cancer Brachytherapy." Journal of Radiation Research 53, no. 3 (2012): 439–46. http://dx.doi.org/10.1269/jrr.11064.
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Bieniek, E., H. Ashamalla, and A. Guirguis. "Determinants of prostate volume changes following iodine-125 interstitial prostate implant." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 15563. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.15563.
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15563 Purpose: Prostate brachytherapy (PB) has been linked with increase in prostate volume (PV). This study evaluates post- operative PV changes and the variables that might affect prostate swelling. Methods: Twenty four patients (pts) were analyzed. Twelve were treated with PB only, 8 with external beam radiation (EBRT) prior to implant, and 4 with EBRT after PB. Pre-treatment PSA and Gleason score ranges were 1.9–10.8 and 5–8 respectively. Pre- implant and post-implant day 1, 9, 30, and 60 (PV0, PV1, PV9, PV30, and PV60) measurements were done using computed tomography. Univariate analysis of PV change and the following was done: PV0, number of needles, seeds, and needle insertion attempts, seed activity (0.3 vs 0.5mCi), hormonal ablation therapy, and prior EBRT. Urinary symptoms were assessed using International Prostate Scoring System (IPSS). Results: Ninety six PV measurements were done by a single observer. PV0 ranged from 27.1 to 89.4 cc (mean 48.2). Largest PV was observed on day 1 (40.1–118.7, mean 67.1). Successive PV measurements afterwards continued to decrease. Mean PV values on day 9, 30, and 60 were 58.6, 51.5, and 42.3cc respectively. The differences between PV0 and all successive PV’s were statistically significant. Mean increase in PV1 from PV0 was 18.9±16.8cc (p<0.001), PV0 and PV9 9.7cc, PV0 and PV30 2.6cc. PV60 was smaller than PV0 by an average of 6.6cc. Statistically significant positive correlation was found between PV increase and seed activity (p=0.02) while treatment with EBRT prior to PB was associated with less prostate swelling (p=0.043). Other variables were not significantly correlated with PV changes. Although the mean IPSS score increased from pre-implant value of 9.2 to 13.7 on day 60, the differences between IPSS values were not statistically significant. Conclusions: Maximum prostate size is observed on the first day after implant. Prostate begins to decrease in size between day 1 and day 9 and reaches pre-procedure volume after day 30. Higher seed activity results in greater prostate swelling, while less brachytherapy- induced swelling is observed in patients treated with external radiation prior to implant. Resolution of prostate swelling does not appear to parallel with improvement in urinary symptoms in the first 2 months after implant. No significant financial relationships to disclose.
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Hirose, K., M. Aoki, M. Sato, H. Akimoto, Y. Hatayama, H. Kawaguchi, Y. Hashimoto, et al. "A Retrospective Analysis of the Relationship Between Prescribed Dose and Dosimetric Advantage Taken by Intraoperative Built Custom Linked Seeds in Iodine-125 Prostate Brachytherapy." International Journal of Radiation Oncology*Biology*Physics 96, no. 2 (October 2016): E254. http://dx.doi.org/10.1016/j.ijrobp.2016.06.1261.
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Chapet, Olivier, Edwige Rigal, Corina Udrescu, Abdeslam Hassouni, Alain Ruffion, and Vincent Piriou. "First experience of prostate brachytherapy under hypnosedation." Journal of Clinical Oncology 34, no. 2_suppl (January 10, 2016): 149. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.149.
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149 Background: Hypnosedation is an alternative to general or spinal anesthesia and may reduce bleeding, postoperative recovery time, as well as potential side-effects of anesthesia. In our department, hypnosedation has been used for prostate brachytherapy (PBT). Levels of pain, comfort, anxiety and satisfaction were evaluated prospectively and are reported. Methods: Twenty-seven patients were treated with BT under hypnosedation. Anesthesia was limited to a perineal injection of 30cc of xylocaine. The same radiation-oncologist and the same anesthesiologist performed all the interventions and hypnosedations, respectively. A dose of 145Gy was delivered to the prostate using iodine-125 linked-seeds. In case of pain or discomfort during hypnosedation, the patient could ask to switch from hypnosedation to general anesthesia. Visual Analog Scales (VAS), from 0 to 10 points, were used to evaluated the lowest, mean and highest level of pain, comfort and anxiety. The VAS forms were completed by the patients in the same day (D1), before (anxiety and pain) and after the intervention (pain and comfort), and 8 weeks later (pain and comfort). Results: Only two patients had a general anesthesia, because they didn’t reach the hypnotic level and failed to follow the hypnosedation procedure. In the table below are presented the results (average and range) of the VAS scores for pain and comfort for the remaining 25 patients. Twenty-four (88.9%) patients would choose this approach again and recommend it to other patients. One patient would prefer a general anesthesia due to the discomfort of the position during the procedure (leg cramps). For all the patients, the short post-operative recovery time and their active participation to the treatment were two major advantages of the hypnosedation. Conclusions: To our knowledge, this is the first experience of brachytherapy under hypnosedation. Our first results demonstrate that hypnosedation is a feasible and comfortable alternative method to anesthesia, perfectly suitable for PBT. [Table: see text]
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Alberti, Winfried, Stephan Divoux, Bernhard Pothmann, Peter Tabor, Klaus-Peter Hermann, and Dietrich Harder. "Autoradiography for iodine-125 seeds." International Journal of Radiation Oncology*Biology*Physics 25, no. 5 (April 1993): 881–84. http://dx.doi.org/10.1016/0360-3016(93)90319-q.
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Rostelato, M. E., C. Zeituni, A. Feher, J. Moura, E. Moura, H. Nagatomi, J. Manzoli, C. Souza, and C. Silva. "146 poster: Iodine-125 Seeds - Brazillian Panel." Radiotherapy and Oncology 91 (May 2009): S52—S53. http://dx.doi.org/10.1016/s0167-8140(15)34403-0.
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Li, Yuliang, Wei Wang, Zhonghao Liu, Jingrun Zhu, Chuanwang Wu, Mingyang Liu, Yongzheng Wang, Wujie Wang, and Bin Liu. "Brachytherapy with iodine 125 seeds for bone metastases." Journal of Cancer Research and Therapeutics 13, no. 5 (2017): 742. http://dx.doi.org/10.4103/jcrt.jcrt_399_17.
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Tong, Yu-Suo, and Xiu-Feng Cao. "Brachytherapy with iodine-125 seeds for hepatocellular carcinoma." World Chinese Journal of Digestology 21, no. 29 (2013): 3072. http://dx.doi.org/10.11569/wcjd.v21.i29.3072.
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Zhang, Wanfu, and Kaiyuan Luo. "Migration of Radioactive Iodine-125 Seeds: Case Report." Indian Journal of Surgery 75, no. 4 (June 19, 2012): 263–64. http://dx.doi.org/10.1007/s12262-012-0604-7.
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Xiong, Liting, Yuhan Yang, Mengyuan Li, Ping Jiang, Chunxiao Li, and Junjie Wang. "Advancements and challenges in interstitial brachytherapy using iodine-125 seeds." Advances in Radiotherapy & Nuclear Medicine 1, no. 2 (October 3, 2023): 0914. http://dx.doi.org/10.36922/arnm.0914.
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Radiation therapy has been used for over a century in the treatment of tumors, with interstitial tissue treatment using radioactive seeds playing a key role in this approach. Iodine-125 (I-125) seeds are the most commonly used radioactive sealed source for permanent interstitial brachytherapy. In recent decades, significant advancements have been made in the field of interstitial radiation therapy. The development of three-dimensional (3D)-printed personalized templates, treatment planning systems, and robot-assisted systems have significantly improved the accuracy of I-125 brachytherapy. This review summarizes the advances in technology, radiobiology, physics, and immunology of I-125 brachytherapy. These advancements have improved the accuracy of dose delivery and increased the effectiveness of I-125 interstitial brachytherapy. In particular, the utilization of 3D-printed personalized templates has allowed for customized treatment planning and more precise dose delivery. Robot-assisted systems have also made significant contributions by assisting in the precise placement of radioactive seeds during treatment. However, several challenges persist within the field of interstitial I-125 brachytherapy. One of the current issues is the difficulty in accurately predicting the biological response to radiation therapy in individual patients. Addressing this challenge represents an important area for further research, as it has the potential to improve treatment outcomes and minimize side effects. In addition, there is a need for more research into the utilization of immunotherapy in conjunction with interstitial brachytherapy, as this combination has demonstrated promise in preclinical studies. Overall, this review provides a comprehensive overview of the advances and challenges associated with interstitial brachytherapy using I-125 seeds. These advancements offer a theoretical basis for achieving precise and remote medical care in brachytherapy. As technology continues to evolve, it is likely that interstitial brachytherapy will emerge as an even more effective treatment option for cancer patients.
Dissertations / Theses on the topic "Linked Iodine 125 seeds"
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Brun, Thomas. "Développement de méthode dosimétrique et de quantification du volume cible par IRM multiparamétrique pour le traitement ultra-focal du cancer de la prostate en curiethérapie de grains liés d'iode-125 personnalisés." Electronic Thesis or Diss., Université de Toulouse (2023-....), 2024. http://www.theses.fr/2024TLSES071.
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Le traitement conventionnel du cancer localisé de la prostate, le plus fréquent chez l'homme, repose sur des approches de traitement de la glande entière et entraîne un risque important d'effets indésirables en termes de continence et de sexualité. A l'heure actuelle, les différentes stratégies de traitements peuvent être une chirurgie, une radiothérapie externe ou une curiethérapie interstitielle. Cependant, des échantillons chirurgicaux ont montré que chez une proportion significative de patients, le risque de progression du cancer était lié à un seul foyer de cancer indifférencié. De ce fait, le traitement de la lésion index primitive permettrait à la fois de lutter contre le cancer et de préserver la qualité de vie des patients. Bien que les développements récents des technologies d'imagerie et de biopsie puissent décrire l'étendue du cancer, le défi de focaliser avec précision le traitement sur la cible unique reste une tâche ardue, et les traitements focaux proposés entre la surveillance active du cancer de la prostate à faible risque et le traitement définitif des formes agressives sont encore des options en cours d'évaluation. En effet, les traitements focaux soulèvent donc des questions encore imparfaitement résolues pour un montage clinique optimal : Comment définir précisément le volume cible? Comment focaliser l'agent thérapeutique sur cette cible? Et enfin, comment surveiller le reste de la glande après le traitement ? Ce projet de thèse a pour but de développer et d'évaluer la faisabilité dosimétrique d'un traitement expérimental ultra-focal d'un cancer de la prostate par une technique de curiethérapie de grains liés d'iode 125 (I-125) et de développer une méthode de quantification dans la définition précise du foyer primitif tumoral à l'aide d'imagerie IRM multiparamétrique (IRMmp). Pour cela, le nombre et l'activité des grains d'I-125 utilisées pour la curiethérapie conventionnelle de la prostate sont définis sur la base du volume de la glande entière (environ 2 grains/cc). Par définition, la curiethérapie ultra-focale s'adresse à des cibles de formes complexes et de plus petits volumes, ce qui nous a poussé à développer une méthode dosimétrique d'implantation de multiples grains de faible activité. Deuxièmement, l'objectif de précision dans la délivrance des grains nous a conduit à mettre en œuvre l'utilisation séquentielle de trois systèmes d'imagerie distincts: l'IRMmp pour informer sur la position et le volume de la cible, l'échographie transrectale 3D (TRUS) pour délivrer un marqueur fiduciaire dans la cible tirant parti de la fusion non rigide avec l'IRMmp et une sonde échographique 2D biplanaire requis pour la planification du traitement et la pose des grains. Enfin, l'évaluation de la qualité du traitement - c'est-à-dire de la dose délivrée à la cible unique, par opposition à la glande entière en curiethérapie conventionnelle - a été rendu possible grâce au développement d'une méthode de quantification basée sur la définition précise de la position du volume cible tumoral à traiter à partir des données des imageries IRMmp et en comparaison par rapport aux données dosimétriques obtenues pour chaque patient de l'étudeThe conventional treatment of localized prostate cancer, the most common cancer in men, is based on whole-gland treatment approaches and drives a significant risk of adverse effects in terms of continence and sexuality. Currently, various treatment strategies include surgery, external beam radiotherapy, or brachytherapy. However, surgical specimens have shown that in a significant proportion of patients, the risk of cancer progression is associated with a single focus of undifferentiated cancer. Therefore, treating the primary index lesion would achieve both cancer control and preservation of quality of life. Although recent developments in imaging and biopsy technologies can outline the extent of the cancer, the challenge of focusing the required precision with the treatment agent remains a daunting task, and focal treatments proposed between active surveillance of low-risk Prostate Cancer and definitive treatment of aggressive forms are still options under assessment Indeed, focal treatments raise questions that are still imperfectly resolved for an optimal clinical implementation: How to precisely define the target volume? How to focus the therapeutic agent on this target? And finally, how to monitor the rest of the gland after treatment? The aim of this thesis project is to develop and evaluate the dosimetric feasibility of an experimental ultra-focal treatment for prostate cancer using iodine-125 seeds brachytherapy and to develop a quantification method for the precise definition of the primary tumor focus using multiparametric MRI (mpMRI) imaging. To achieve this, the number and activity of I-125 seeds used for conventional prostate brachytherapy are defined based on the volume of the entire gland (approximately 2 seeds/cc). By definition, ultra-focal brachytherapy targets complex-shaped and smaller volumes, prompting us to develop a dosimetric method for implanting multiple seeds with low activity. Secondly, the precision objective in seed delivery led us to implement the sequential use of three distinct imaging systems: mpMRI to inform on the position and volume of the target, 3D transrectal ultrasound to deliver a fiducial marker into the target leveraging non-rigid fusion with mpMRI, and a 2D biplanar ultrasound probe required for treatment planning and seed placement. Finally, the evaluation of treatment quality - that is, the dose delivered to the single target as opposed to the entire gland in conventional brachytherapy - was made possible by developing a quantification method based on the precise definition of the position of the target tumor volume to be treated from mpMRI data and compared to dosimetric data obtained for each patient in the study
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Al-Qaisieh, Bashar. "Dose analysis of iodine-125 seeds for prostate brachytherapy." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413209.
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Souza, Raquel Valério de. "Estudo do processo de síntese dos dímeros lactídeo e glicolídeo para obtenção do PLGA Poli (Ácido Lático-co-Ácido Glicólico) utilizados na produção de fontes radioativas." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-05122017-155143/.
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Câncer é a segunda causa de morte no mundo e foi responsável por 8,8 milhões de mortes em 2015, de acordo com a Organização Mundial da Saúde (OMS). Segundo o Instituto Nacional do Câncer (INCA), essa doença é um problema de utilidade pública. Em valores absolutos, o câncer de próstata, neoplasia maligna mais comum entre os homens, é o sexto tipo mais comum no mundo. Dentre os tratamentos para câncer de próstata estão a cirurgia, quimioterapia e radioterapia. Um dos principais tipos de radioterapia é a braquiterapia, realizada por meio de sementes radioativas de iodo-125, que são inseridas na próstata do paciente e liberam pequenas doses de radiação. Essas sementes podem ser introduzidas soltas ou em cordas poliméricas Quando introduzidas soltas, de acordo com a literatura, essas sementes podem migrar para outros órgãos. Para evitar essa migração, usa-se as sementes em cordas poliméricas. As cordas poliméricas são constituídas pelo poli(ácido lático-co-ácido glicólico), PLGA. O PLGA pode ser obtido por meio de seus dímeros cíclicos: glicolídeo e lactídeo. Esses dímeros, por sua vez, podem ser produzidos a partir de seus respectivos monômeros, os ácidos glicólico e lático. O objetivo desse trabalho foi analisar e discutir as condições favoráveis à síntese dos dímeros glicolídeo e lactídeo, dentre elas, etapas do processo e valores de temperatura e pressão. Foram executados sete experimentos com diferentes temperaturas e pressões nas três etapas da síntese: desidratação do ácido, formação do pré-polímero e despolimerização do pré-polímero. Na etapa intermediária da síntese, foi obtido o PLA quando foram utilizadas temperaturas acima de 150°C. A etapa final mostrou que temperaturas abaixo de 200°C não formam os dímeros.Cancer is the second leading cause of world death and it was responsible for 8.8 million deaths in 2015, according to the World Health Organization (WHO). According to the National Cancer Institute (INCA), this disease is a public utility problem. In absolute values, prostate cancer, the most common cancer among men, is the sixth most common type in the world. Among prostate cancer treatments are surgery, chemotherapy and radiotherapy. One of the main radiotherapy types is brachytherapy, performed by iodine-125 radioactive seeds, which are inserted into the patient\'s prostate and release small radiation doses. These seeds can be introduced loose or such as stranded seeds. When introduced such as loose seeds, according to literature, these seeds can migrate to other organs. In order to avoid this migration, it is used stranded seeds. The stranded seeds are composed of PLGA, poly(lactic acid-co-glycolic acid). PLGA can be obtained by its cyclic dimers: glycolide and lactide. These dimers can be produced from their respective monomers, glycolic and lactic acids. The purpose of this study was to analyze and discuss the favorable conditions of the glycolide and lactide synthesis, such as process steps and temperature and pressure values. Seven experiments were performed at different temperatures and pressures in three synthesis steps: acid dehydration, prepolymer formation and depolymerization of prepolymer. In intermediary step, the PLA was obtained when temperatures were above 150°C. The final step showed that dimers are not formed at temperatures below 200°C.
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MOURA, JOAO A. "Desenvolvimento e construção de sistema automatizados para controle de qualidade na produção de sementes de iodo-125." reponame:Repositório Institucional do IPEN, 2015. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26454.
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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2016-07-01T11:08:37Z
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Tese (Doutorado em Tecnologia Nuclear)
IPEN/T
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Lima, José Rodrigues de. "Projeto e desenvolvimento de um dispositivo automático de controle e alimentação de tubos de titânio e fios de prata para a produção de sementes de Iodo - 125." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-05122016-144234/.
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No Brasil, o câncer de próstata é um dos tipos de câncer que mais afeta a população masculina, sendo o segundo mais incidente, ficando atrás apenas do câncer de pele não melanoma que é o mais ocorrente na população. Existem vários procedimentos para o tratamento do câncer de próstata, dentre eles temos a braquiterapia com sementes de Iodo- 125, este método é realizado inserindo sementes com Iodo radioativo na próstata do paciente. As sementes são constituídas de uma capsula de titânio medindo 0,8 mm de diâmetro por 4,5 mm de comprimento com um fio de prata medindo 0,5 mm de diâmetro por 3,0 mm de comprimento, adsorvido com Iodo-125, que é selado por meio de solda laser. As tecnologias usadas nos processos de produção de sementes de Iodo-125 são protegidas por patentes e a obtenção dos direitos de produção apresenta um custo elevado, inviabilizando a sua produção por esses processos devidos aos custos. O objetivo deste trabalho é desenvolver o projeto de um dispositivo para a contagem dos tubos de titânio e dos fios de prata usados na confecção das sementes de Iodo-125, este objetivo foi atingido estabelecendo uma metodologia para o posicionamento dos fios de prata e sua condução para o processo de contagem. Para tanto, foi projetado, construído e utilizado um novo dispositivo que se encontra hoje totalmente operacional. Foram utilizados motores de passo e sensores óticos para auxiliar no processo de automação do conjunto.In Brazil, prostate cancer is the kind of cancer that affects the major quantity of male population worldwide, the second most incident, only affecting less people than the nonmelanoma skin cancer which is the most frequently occurring in the population. There are several procedures for the treatment of prostate cancer, including brachytherapy using Iodine-125 seeds. This method is performed by inserting seed with radioactive iodine in the prostate of the patient. The seeds are composed of a titanium capsule measuring 0.8 mm in diameter and 4.5 mm in length with a silver wire measuring 0.5 mm in diameter and 3.0 mm in length adsorbed Iodine-125, which it is sealed by laser welding. The technology used in the iodine-125 seeds production processes are protected by patents and obtaining the production rights presents a high cost. The objective of this work is to develop the design of a device for counting the titanium tubes and silver wires used in making the seeds of iodine-125, this goal was achieved by establishing a methodology for the placement of silver wires and the movement for the counting process. Thus, it was designed, built and used a new device that is now fully operational. Stepper motors, and optical sensors were used to assist in the automation of the assembly process.
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Júnior, Fernando dos Santos Peleias. "Desenvolvimento da metodologia para síntese do poli(ácido lático-co-ácido glicólico) para utilização na produção de fontes radioativas." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-19082013-133927/.
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A Organização Mundial da Saúde (OMS) relata o câncer como uma das principais causas de morte no mundo. O câncer de próstata é o segundo tipo de câncer mais prevalente em homens. Uma modalidade de tratamento que vem sendo bastante utilizada é a braquiterapia, que consiste na introdução de sementes com material radioativo no interior do orgão. Sementes de Iodo-125 podem ser inseridas soltas ou em cordas poliméricas bioabsorvíveis. As sementes em cordas poliméricas apresentam algumas vantagens, pois reduzem a taxa de migração das sementes, evento que poderia afetar a dosimetria da região e causar danos desnecessários a tecidos ou órgãos sadios. Para as sementes de Iodo-125 em cordas poliméricas, utiliza-se a poliglactina 910, (poli(ácido lático-co-ácido glicólico)) (PLGA), com cobertura de poliglactina 370 (Vicryl®). Foi proposto neste trabalho, o estudo e desenvolvimento da metodologia de síntese do biopolímero PLGA, via polimerização por abertura de anéis, assim como sua caracterização, com o propósito de utilizar o material sintetizado para fabricar um material similar ao RAPID-Strand®. Os resultados obtidos demonstram que, através da metodologia utilizada, foi possível determinar os melhores parâmetros de reação (tempo e temperatura) para o PLGA na proporção 80/20 (lactídeo/glicolídeo). Com uma temperatura de 110ºC e tempo de reação de 24h, foi possível obter 86% de rendimento, e com o aumento o tempo de reação para 72h, o rendimento é superior a 90%. Os valores de massas moleculares obtidas entre os testes, ainda são muito baixos quando comparados com os valores obtidos por outros autores na literatura (cerca de 20%). Falhas na selagem das ampolas, deixando-os vulneráveis à umidade e oxigênio, ou a falta de uma sistema eficiente de agitação podem ser possíveis explicações para estes resultados. Um reator químico adequado poderia solucionar o problema. Em relação à caracterização, as técnicas utilizadas confirmaram a estrutura esperada do polímero, e a maior proporção das unidades provenientes do dímero lactídeo, em relação ao glicolídeo.According to World Health Organization (WHO), cancer is a leading cause of death worldwide. Prostate cancer is the second most common cancer in men. A method of radiotherapy which has been extensively used is brachytherapy, where radioactive seeds are placed inside the area requiring treatment. Iodine-125 seeds can be placed loose or stranded in bioabsorbable polymers. Stranded seeds show some advantages, since they reduce the rate of seed migration, an event that could affect the dosimetry of the prostate and cause unnecessary damage to healthy tissues or organs. For Iodine-125 stranded seeds, polyglactin 910 (poly(lactic-co-glycolic acid)) (PLGA), with a coverage of polyglactin 370 (Vicryl ®) is used. It was purposed in this dissertation, the study and development of the synthesis methodology for PLGA via ring-opening polymerization, as well as its characterization, with the objective of using the synthesized material to manufacture a material similar to RAPID Strand®. The results obtained show that it was possible to determine the optimal reaction parameters (time and temperature) for PLGA in 80/20 (lactide/glycolide) ratio. Using a temperature of 110 ° C and reaction time of 24h, a yield of 86% was obtained, and increasing the reaction time to 72 hours, the yield was higher than 90%. The molecular mass values obtained from the samples are still very low compared to those obtained by other authors in the literature (about 20%). Failures in the sealing of vials, leaving them vulnerable to moisture and oxygen, or lack of an efficient stirring system might be possible explanations for these results. A suitable chemical reactor could solve the problem. Regarding polymer characterization, all techniques used not only confirmed the expected structure of the polymer, but also showed the highest proportion of lactide units compared to to glycolide units.
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LIMA, JOSE R. de. "Projeto e desenvolvimento de um dispositivo automático de controle e alimentação de tubos de titânio e fios de prata para a produção de sementes de Iodo - 125." reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26944.
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Submitted by Marco Antonio Oliveira da Silva (maosilva@ipen.br) on 2016-12-22T13:06:17Z
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No Brasil, o câncer de próstata é um dos tipos de câncer que mais afeta a população masculina, sendo o segundo mais incidente, ficando atrás apenas do câncer de pele não melanoma que é o mais ocorrente na população. Existem vários procedimentos para o tratamento do câncer de próstata, dentre eles temos a braquiterapia com sementes de Iodo- 125, este método é realizado inserindo sementes com Iodo radioativo na próstata do paciente. As sementes são constituídas de uma capsula de titânio medindo 0,8 mm de diâmetro por 4,5 mm de comprimento com um fio de prata medindo 0,5 mm de diâmetro por 3,0 mm de comprimento, adsorvido com Iodo-125, que é selado por meio de solda laser. As tecnologias usadas nos processos de produção de sementes de Iodo-125 são protegidas por patentes e a obtenção dos direitos de produção apresenta um custo elevado, inviabilizando a sua produção por esses processos devidos aos custos. O objetivo deste trabalho é desenvolver o projeto de um dispositivo para a contagem dos tubos de titânio e dos fios de prata usados na confecção das sementes de Iodo-125, este objetivo foi atingido estabelecendo uma metodologia para o posicionamento dos fios de prata e sua condução para o processo de contagem. Para tanto, foi projetado, construído e utilizado um novo dispositivo que se encontra hoje totalmente operacional. Foram utilizados motores de passo e sensores óticos para auxiliar no processo de automação do conjunto.
Dissertação (Mestrado em Tecnologia Nuclear)
IPEN/D
Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP
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PELEIAS, JUNIOR FERNANDO dos S. "Desenvolvimento da metodologia de síntese e purificação dos dímeros L-lactídeo e glicolídeo para produção do poli (ácido lático-co-ácido glicólico) para utilização na produção de fontes radioativas." reponame:Repositório Institucional do IPEN, 2017. http://repositorio.ipen.br:8080/xmlui/handle/123456789/28054.
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Submitted by Pedro Silva Filho (pfsilva@ipen.br) on 2017-11-23T12:28:11Z
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A Organização Mundial da Saúde (OMS) relata o câncer como uma das principais causas de morte no mundo. O câncer de próstata é o segundo tipo de câncer mais prevalente em homens, com cerca de 1,1 milhão de casos diagnosticados em 2012. Braquiterapia com iodo-125 é uma método de radioterapia que consiste na introdução de sementes com material radioativo no interior do órgão a ser tratado. As sementes de iodo-125 podem ser inseridas soltas ou em cordas poliméricas bioabsorvíveis, mais comumente o poli(ácido lático-co-ácido glicólico) (PLGA). A função do polímero é reduzir a possibilidade de migração das sementes, o que poderia ser prejudicial para órgãos e tecidos saudáveis. De modo a reduzir os custos do tratamento, a síntese dos dímeros L-lactídeo e glicolídeo, para posterior utilização para preparação do PLGA, por meio da polimerização por abertura de anel, é proposta neste trabalho. Adicionalmente, propõe-se a utilização do amino-alcóxido tris(fenolato) de zircônio (IV) como alternativa ao usual octanoato de estanho (SnOct2), uma vez que a toxicidade do estanho permanece como obstáculo na produção do PLGA para aplicações biomédicas. Embora o iniciador de zircônio seja mais lento do que o SnOct2, massas molares relativamente elevadas foram obtidas quando razões monômero/iniciador (M/I) de 1000/1 (24 h), e 5000/1 (48 h) foram utilizadas. Considerando que as unidades glicolila (GA) são mais reativas do que as unidades lactila (LA), tempos longos de reação são necessários para atingir uma razão LA/GA próxima do objetivo do trabalho (85/15). O grau de racemização também depende do iniciador utilizado. As reações de polimerização realizadas com o iniciador de zircônio mostraram um maior grau de racemização, quando comparadas com aquelas realizadas com o SnOct2. Também foi observado um ligeiro aumento na racemização com o tempo. Considerando os resultados obtidos na síntese e purificação dos dímeros, e na síntese do PLGA em condições semelhantes às industriais, foi possível preparar o polímero de alta massa molar com um custo dezenas de vezes inferior ao custo do PLGA no mercado internacional. Os efeitos da radiação gama no PLGA também foram estudados. Doses normalmente aplicadas para esterilizar materiais para aplicações biomédicas foram empregadas: 10, 18, 25 e 50 kGy. A massa molar de todas as amostras irradiadas diminuiu de uma forma proporcional à dose até 56% de perda para 10 kGy e 72% para 50 kGy porém, são menos pronunciadas para doses mais elevadas. Alterações nas propriedades térmicas, tais como temperatura de fusão, temperatura de transição vítrea e a entalpia de cristalização e fusão foram também observadas após a irradiação.
Tese (Doutorado em Tecnologia Nuclear)
IPEN/T
Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP
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BRANCO, ISABELA S. L. "Estudo dos efeitos na dose devido à heterogeneidade em braquiterapia com fontes de I125." reponame:Repositório Institucional do IPEN, 2017. http://repositorio.ipen.br:8080/xmlui/handle/123456789/28045.
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Submitted by Pedro Silva Filho (pfsilva@ipen.br) on 2017-11-23T09:59:05Z
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A braquiterapia de baixas taxas de dose realizada com sementes de 125I tem sido amplamente usada por décadas em variados sítios anatômicos, com bons resultados clínicos. O advento de algoritmos para cálculo de dose baseados em modelos (MBDCAs) permitiu aprimorar oestudo de deposição da dose considerando heterogeneidades como diferentes tecidos, órgãos,aplicadores com composições diferentes da água, proporcionando a análise em geometriascomplexas. As simulações matemáticas realizadas através destes algoritmos possibilitam odesenvolvimento de modelos fisicamente mais acurados que estendem sua aplicabilidade àverificação de sistemas de planejamento em braquiterapia. Neste trabalho foram estudadasconfigurações de objetos simuladores confeccionados para medidas experimentais e simuladosatravés do código MCNP de Monte Carlo a fim de observar as diferenças ocasionadas pelaintrodução de heterogeneidades quando presentes fontes de 125I de baixa taxa de dose. Para estepropósito, distintas as vertentes do tema foram abordadas, entre elas o estudo da influênciaexercida pelos parâmetros de densidade e composição dos materiais tecido equivalentes. Osresultados obtidos demonstraram que, o efeito que a composição de cada um dos materiaisexerce sobre a deposição de dose é mais expressivo que o efeito de sua densidade. Em outroestudo, foi estabelecida uma relação para estimar, de maneira simples, a dose de atenuação detecidos heterogêneos a partir da aferição ou simulação da dose obtida num objeto simuladorconstituído por PMMA, metodologia que pode ser desenvolvida e implementada na rotina clínica.Para complementação das análises dos estudos dosimétricos com a presença deheterogeneidades, foi realizada a validação da geometria simulada da semente de 125I, onde sereproduziu a metodologia de cálculo dosimétrico presente no TG-43 da AAPM. Além disto, foirealizado o estudo teórico da dependência energética dos dosímetros termoluminescentes paraanalisar a variação de sua resposta conforme a energia. A metodologia desenvolvida para oestudo dos efeitos da heterogeneidade na deposição de dose é recomendada na avaliação desistemas de planejamento computadorizados que possuem algoritmos de cálculo de dosebaseados em modelos, quando utilizadas fontes de 125I com baixa taxa de dose, de forma acontribuir na incorporação de novas estimativas de doses com maior acurácia.
Dissertação (Mestrado em Tecnologia Nuclear)
IPEN/D
Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP
Book chapters on the topic "Linked Iodine 125 seeds"
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Voges, J., H. Treuer, W. Schlegel, O. Pastyr, and V. Sturm. "Interstitial Irradiation of Cerebral Gliomas with Stereotactically Implanted Iodine-125 Seeds." In Advances in Stereotactic and Functional Neurosurgery 10, 108–11. Vienna: Springer Vienna, 1993. http://dx.doi.org/10.1007/978-3-7091-9297-9_25.
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Trippel, Michael, Thomas Reithmeier, and Guido Nikkhah. "Interstitial Radiosurgery with Iodine-125 Seeds in the Treatment of Brain Metastases, Glial Tumours and Benign Intracranial Lesions." In Stereotactic and Functional Neurosurgery, 101–6. Vienna: Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1482-7_16.
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Voges, J., H. Treuer, W. J. Schlegel, O. Pastyr, and V. Sturm. "Combined Radiotherapy of High-Grade Gliomas with Stereotactic Implanted Iodine-125 Seeds and Fractionated Low-Dose Rate Beam Irradiation: Preliminary Results." In Neurosurgical Standards Cerebral Aneurysms Malignant Gliomas, 298–303. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77109-5_53.
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ROSTELATO, M., C. SILVA, P. RELA, H. CASIGLIA, C. ZEITUNI, A. FEHER, and V. LEPKI. "Development and production of iodine-125 seeds for brachytherapy." In Recent Advances in Multidisciplinary Applied Physics, 543–46. Elsevier, 2005. http://dx.doi.org/10.1016/b978-008044648-6/50082-3.
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Niu, Lizhi, Keqiang Xu, and Kecheng Xu. "Percutaneous Cryoablation in Combination with Brachytherapy with Iodine-125 Seeds for Treatment of Centrally Located Non-Small-Cell Lung Cancer." In Modern Cryosurgery for Cancer, 459–72. WORLD SCIENTIFIC, 2012. http://dx.doi.org/10.1142/9789814329668_0023.
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Valentim, Sebastião Marcos Silva, Petterson Baptista da Luz, Elaidy Laura Oliveira Cardoso, Gabriel Moretto, Antônio Carlos Silva Moreira, Anna Júlia Cardoso Amaral, Bruna Samy de Oliveira Miranda, Loryane Ribeiro Freire, and Karina Leite de Oliveira. "Viability of Sucupira-Branca (Pterodon emarginatus VOGEL.) seeds collected directly from the mother tree and on the soil." In DEVELOPMENT AND ITS APPLICATIONS IN SCIENTIFIC KNOWLEDGE. Seven Editora, 2023. http://dx.doi.org/10.56238/devopinterscie-188.
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The species Pterodon emarginatus Vogel., popularly known as Sucupira-Branca, is a tree belonging to the Fabaceae family and is widely distributed in the Cerrado Biome. Its fruits are widely used in the fight against rheumatism, and diabetes and are mainly used in the treatment of inflammations, its wood is resistant and can be used in constructions, in addition, the species has the potential for reforestation actions. The objective of this work was to evaluate the viability of Sucupira-Branca seeds collected directly from the mother tree and on the ground, in a transition region between the Cerrado Biome and the Amazon Forest in Cáceres-MT. To carry out the study, 1,200 Sucupira-Branca fruits were collected, of which 600 were collected directly from the mother tree and the other 600 were collected on the soil located below it. The fruits were opened and the viability of their seeds was evaluated qualitatively and visually, analyzing whether they were whole, without imperfections, and with normal color (light brown), where the number of viable and non-viable seeds of the fruits was counted. fruits collected both directly from the parent tree and those that were on the ground so that it could analyze whether there is a difference in the viability of the seeds collected in both places. In total, 1,200 seeds were evaluated, of which, of the 600 seeds collected on the ground, only 160 were viable, and of the 600 collected directly from the mother tree, 285 were viable, 125 more seeds than those collected on the ground. Because of this, we can see that the simple act of not opening the Sucupira-Branca fruits to remove the seed before planting, which is very common, may be linked to the low germination rate of the species, as this attribute may be related to the viability of its seeds, which is also very low. The characteristic can only be evaluated through the opening of the fruits. We can conclude that a factor that is connected with the low viability of the seeds and possibly also with the low germination is the place where they are collected, which, because of the results found, we can observe that the collection of the Sucupira-Branca fruits carried out directly from the matrix tree presents greater seed viability, and may also present a higher germination rate.
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Taber, Douglass F. "C-H Functionalization: The Chen Synthesis of Celogentin C." In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0019.
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Christian R. Goldsmith of Auburn University developed (Synlett 2010, 1377) a method for radical chlorination of 1 using commercial peracetic acid. Noritaka Mizuno of the University of Tokyo devised (Nat. Chem. 2010, 2, 478) a bulky polyoxometalate that mediated the selective hydroxylation of the secondary C-H bonds of 3. Christina White of the University of Illinois showed (Science 2010, 327, 566) that Fe-mediated C-H oxidation is sensitive to the expected electronic effects, so that 5 was selectively oxidized to 6. Irena S. Akhrem of the A. N. Nesmeyanov Institute of Organoelement Compounds established (Tetrahedron Lett. 2010, 51, 259) that a C-H bond of 7 could be efficiently converted to a C-C bond. Melanie S. Sanford of the University of Michigan extended (Organic Lett. 2010, 12, 532) directed palladation to 9, effecting selective acetoxylation of the methyl group. Herman O. Sintim of the University of Maryland observed (Angew. Chem. Int. Ed. 2010, 49, 3964) that the O-linked diazoamide 11 selectively cyclized to 12. The corresponding C-linked diazoamide gave only five-membered ring formation. Yasushi Obora and Yasutaka Ishii of Kansai University devised (Organic Lett. 2010, 12, 1372) conditions for the selective allylic amination of 13. Marvin J. Miller of the University of Notre Dame developed (Tetrahedron Lett. 2010, 51, 328) the nitrosoisoxazole 16 for the allylic amination of 15. David A. Powell of Merck Frosst established (J. Org. Chem. 2010, 75, 2726) a protocol for the selective amination of the aromatic methyl group of 18. Ying-Yeung Yeung of the National University of Singapore effected (Organic Lett. 2010, 12, 2128) selective allylic oxidation of 21 with a hypervalent iodine reagent. Gullapalli Kumaraswamy of the Indian Institute of Chemical Technology, Hyderabad, allylated (J. Org. Chem. 2010, 75, 3916) an amine 23 using commercial aqueous t -BuOOH. Corey R. J. Stephenson of Boston University used (J. Am. Chem. Soc. 2010, 132, 1464) visible light to activate 26 for homologation to 27. In the course of a synthesis of the bicyclic nonribosomal peptide celogentin C, isolated from the seeds of the plumed cockscomb Celosia argentea, Gong Chen of Pennsylvania State University took advantage (Angew. Chem. Int. Ed. 2010, 49, 958) of Pd activation to effect specific coupling of the iodoindole 29 with the leucine derivative 28. On a 4-gram scale, this coupling proceeded in 85% yield.
Conference papers on the topic "Linked Iodine 125 seeds"
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Huanhuan Hou, Bo Liu, and Fugen Zhou. "A method to detect iodine-125 seeds in lung CT." In 2015 IET International Conference on Biomedical Image and Signal Processing (ICBISP 2015). Institution of Engineering and Technology, 2015. http://dx.doi.org/10.1049/cp.2015.0766.
Full textReports on the topic "Linked Iodine 125 seeds"
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Yu, Xue, Jin Zhu, Tianhao Shen, Chen Zhou, Tinghui Jiang, and Yan Liu. Prognostic role of Iodine-125 seeds combined with esophageal stents for un resectable malignant esophageal obstruction?a Meta-Analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2023. http://dx.doi.org/10.37766/inplasy2023.11.0108.
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