Dissertations / Theses on the topic 'Linkage'
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Larsen, Stasha Ann Bown. "Record Linkage." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3833.
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This document explains the use of different metrics involved with record linkage. There are two forms of record linkage: deterministic and probabilistic. We will focus on probabilistic record linkage used in merging and updating two databases. Record pairs will be compared using character-based and phonetic-based similarity metrics to determine at what level they match. Performance measures are then calculated and Receiver Operating Characteristic (ROC) curves are formed. Finally, an economic model is applied that returns the optimal tolerance level two databases should use to determine a record pair match in order to maximize profit.
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Sandford, Andrew John. "Linkage analysis of atopy." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358705.
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Song, Yuhyun. "Linkage Based Dirichlet Processes." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/74970.
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We live in the era of textit{Big Data} with significantly richer computational resources than the last two decades. The concurrence of computation resources and a large volume of data has boosted researchers' desire for developing feasible Markov Chain Monte Carlo (MCMC) algorithms for large parameter spaces. Dirichlet Process Mixture Models (DPMMs) have become a Bayesian mainstay for modeling heterogeneous structures, namely clusters, especially when the quantity of clusters is not known with the established MCMC methods. As opposed to many ad-hoc clustering methods, using Dirichlet Processes (DPs) in models provide a flexible and probabilistic approach for automatically estimating both cluster structure and quantity. While DPs are not fully parameterized, they depend on both a base measure and a concentration parameter that can heavily impact inferences.
Determining the concentration parameter is critical and essential, since it adjusts the a-priori cluster expectation, but typical approaches for specifying this parameter are rather cavalier. In this work, we propose a new method for automatically and adaptively determining this parameter, which directly calibrates distances between clusters through an explicit link function within the DP. Furthermore, we extend our method to mixture models with Nested Dirichlet Processes (NDPs) that cluster the multilevel data and depend on the specification of a vector of concentration parameters. In this work, we detail how to incorporate our method in Markov chain Monte Carlo algorithms, and illustrate our findings through a series of comparative simulation studies and applications.Ph. D.
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Pixton, Burdette N. "Improving Record Linkage Through Pedigrees." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1398.pdf.
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Mansfield, Christopher S. "Fault growth by segment linkage." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362794.
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Warren, Mark. "Photocrystallographic studies of linkage isomerism." Thesis, University of Bath, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538286.
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Davies, Kari. "The practice of crime linkage." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8309/.
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The aim of this thesis was to conduct research into the practice of crime linkage. A literature review was conducted in Chapter 1, finding that the process of crime linkage has started to be explored, although there is scope for much more research in this area. Similarly, while work has been started into crime linkage efficacy and the effect of computerised tools on the process, further work is required. Chapter 2 responded to a 2009 evaluation by Professor Margot of the University of Lausanne about the use of the Violent Crime Linkage Analysis System (ViCLAS). It highlighted a number of issues with the evaluation, but also noted that evaluation of ViCLAS is necessary and requires further exploration. Chapter 3 addressed some of the research gaps highlighted in Chapter 1 by exploring the process of comparative case analysis (CCA), conducted by analysts at the Serious Crime Analysis Section (SCAS). The process was mapped, and the analysts’ decision making processes were discussed in detail, including the behaviours they found useful when linking crimes, the types of searches they conducted, how they decided whether cases were linked, and whether there was any academic research which assisted them. Finally, Chapter 4 aimed to fill some of the research gaps identified in both Chapters 1 and 2 by investigating the interrater reliability coding of ViCLAS in Belgium. Despite improvements to coding uniformity compared to previous research, there is still room for improvement, and the reasons for the associated difficulties of coding was discussed.
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Hernandez-Sanchez, Jules. "Gene mapping using linkage disequilibrium." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/14058.
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The power of QTL detection was studied both empirically and deterministically for several methods. TDT was more powerful than a linkage test, but less powerful than a pure association test. There were no great differences in power between TDTs. One of the TDTs was implemented in BLUP (Best Linear Unbiased Prediction) to study the effect of a candidate gene, the melanocortin 4- receptor (MC4R), on growth, appetite and fatness in pigs. We found significant effects on growth and fatness but not on appetite. TDT uses within families genetic variation. A novel parameter to estimate gene effects using between families genetic variation was also included. If there is no spurious disequilibrium both estimates should be identical, otherwise only the within-families estimator is unbiased. It was more powerful to simulate missing parental genotypes with Gibbs Sampling than analysing data with sib-ship TDTs disregarding parental information. TDT was also used in a genome-wide search for markers associated with bovine spongiform encaphalopathy (BSE). TDT was implemented using logistic regressions, more amenable to statistical modelling than the original form. Maker loci near the Prion Protein gene did not show any associations with BSE, however, markers located on chromosomes 5, 10 and 20, did. A second study that focused on these three chromosomal regions confirmed the association for the marker on chromosome 5. TDT has shown reasonable power and exceptional robustness when mapping QTL in structured populations. Therefore TDT should be part of the gene cartographers’ continuously evolving arsenal of tools for gene mapping. However, previously published TDTs were developed for analysing human populations, whereas domestic/wild populations have different structures and histories that may require alternative statistical analyses. Linked gene flow (LGF) theory can be used for predicting identity-by-descent (IBD) probabilities between individuals. IBD probabilities are at the core of mixed model equations for mapping QTL in outbred populations via variance components estimation. In this thesis, LGF theory was used for determining inbreeding within each individual and chromosomal location using multi-marker information, hence paving the way for further developments.
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Skrivanek, Zachary. "Sequential Imputation and Linkage Analysis." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1039121487.
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Honório, Frederico Santos. "Multi-domain record linkage platform." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/11750.
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Mestrado em Engenharia de Computadores e TelemáticaThis dissertation proposes and presents a technologic framework to perform record linkage. The proposed approach begins by defining a sequence of tasks necessary for record linkage. Then, several methods to split these tasks in small work units are discussed. The solution architecture is based on various executors that carry out the work units in a parallel manner, thereby making the process quicker. Finally, the benefits of using this approach in different contexts are also presented.
Esta dissertação propõe e apresenta uma ferramenta tecnológica que permite realizar mapeamento de registos. A abordagem proposta começa por definir uma sequência de tarefas necessárias para efetuar o mapeamento de registos. São depois discutidos métodos de separar estas tarefas em unidades de trabalho reduzidas. A solução baseia-se numa arquitetura composta por vários executores que levam a cabo essas unidades de trabalho de uma forma paralela, objectivando-se um processo mais rápido. As vantagens da utilização desta abordagem em diferentes contextos são também estudadas.
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Petryshen, Tracey Lynn. "Localization of susceptibility genes involved in phonological coding dyslexia by family linkage and linkage disequilibrium studies." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ64882.pdf.
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Zaffaroni, Daniela. "Mapping of skin cancer susceptibility loci in mice." Thesis, Open University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270016.
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Schoon, Perry L. Hecht Jeffrey. "World Wide Web Hypertext linkage patterns." Normal, Ill. Illinois State University, 1997. http://wwwlib.umi.com/cr/ilstu/fullcit?p9803737.
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Thesis (Ph. D.)--Illinois State University, 1997.Title from title page screen, viewed June 8, 2006. Dissertation Committee: Jeffrey B. Hecht (chair), Patricia H. Klass, Rodney P. Riegle, Roberta K. Weber. Includes bibliographical references (leaves 124-135) and abstract. Also available in print.
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MacKay, Edward Grant. "CIDA and the aid-trade linkage." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26873.
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The Canadian foreign aid program increasingly has been linked to trade and other commercial objectives- How and why has this happened? Has this been a successful linkage? What are the implications for Canada and its foreign aid program of this pursuit of the aid-trade linkage? This thesis attempts to answer these questions by exploring the origins and evolution of Canada's aid program, the political and bureaucratic status of Canada's aid agency, the Canadian International Development Agency (CIDA), and the various policies and policy instruments employed in this recent orientation of aid.
It is here argued that in the pragmatic origins of Canada's aid efforts, beginning with the Colombo Plan of the 1950s, lay the seeds for today's aid-trade policy linkage. These origins enabled the interests and objectives of other federal government departments to intrude on and often supersede developmental considerations in Canadian development assistance. As a result, the creation of a strong central aid agency has consistently been impeded, and the needs of Third World nations consistently overshadowed by domestic concerns.
Exacerbating this situation was the fiscal restraint and domestic recession of the late 1970s and early 1980s. The pressures stemming from these twin problems gave the final impetus for the increasing integration of aid and commerce.
While it is questionable whether linking aid with commerce serves Canada's political and economic interests, in either the short term or the long term, the federal government seems intent on continuing this policy trend. Indeed, the aid-trade linkage superficially resolves a number of administrative problems for CIDA, and enthusiastically is promoted as a bright new opportunity for Canada and its development partners. Conversely, efforts to reverse this policy trend face many obstacles in the Canadian polity and society. In the absence of decisive political leadership on this issue, then, aid-trade linkage is likely to continue.Arts, Faculty of
Political Science, Department of
Graduate
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Perry, Martin Andrew. "Statistical linkage analysis and association studies." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ57208.pdf.
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Creer, Rosalind. "Linkage analysis in highly myopic families." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/56128/.
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The Family Study of Myopia is a research project aiming to discover genetic loci causing susceptibility to high myopia. As part of this investigation, the heritability of refractive error and other ocular components was estimated for a large Irish-Welsh multi-generational pedigree using variance components analysis software, SOLAR. Heritabilities of 0.39 (p=6.92 x 10"5, S.E.=0.14), 1.00 (p=1.84 x 10"4, S.E.=0.22) and 0.30 (p=0.13, S.E.=0.33) were found for refractive error, mean corneal curvature and axial length, respectively. Heritability of refractive error was also calculated using within-family regression and a Markov Chain Monte Carlo method producing estimates of between 0.12 and 0.73. This high heritability of ocular refraction suggests the potential for finding susceptibility loci for the control and development of refractive error. To pinpoint these loci, areas of chromosomes which have previously been suggested to harbour genes controlling refractive error were investigated to determine whether linkage was present within this family. DNA was extracted from mouthwashes and linkage analysis was performed. SOLAR revealed no significant linkage to the loci tested, reinforcing the theory that myopia is a highly heterogenous disease. The maximum twopoint LOD score was within the MYP6 locus at marker D22S1176 (LOD=1.19). Multipoint analysis showed the maximum LOD score at the MYP3 locus, between markers D12S1605 and D12S354 (LOD =1.37). In a separate study of 96 families containing a highly myopic child and the two parents, the involvement of a candidate gene encoding the protein myocilin (MYOC) was examined using an association analysis. There was weak evidence of over- transmission of allele 3 of MYOC 1, a marker in the 5' untranslated region of the gene, and under-transmission of allele 4 of that same marker (both p<0.05). This suggests MYOC may play a small role in the causation of high myopia development but a larger sample is needed to establish this conclusively.
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Burrell, Amy Michelle. "Behavioural case linkage in personal robbery." Thesis, University of Leicester, 2013. http://hdl.handle.net/2381/27687.
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Case linkage uses crime scene behaviours to identify series of crimes committed by the same offender. The research presented here tests the underlying assumptions of case linkage (behavioural consistency and behavioural distinctiveness) by comparing the behavioural similarity of linked pairs of offences (i.e. two offences committed by the same offender) and unlinked pairs of offences (i.e. two offences committed by different offenders). It was hypothesised that linked pairs would be more behaviourally similar than unlinked pairs thereby providing evidence for these two assumptions. Logistic regression and receiver operating characteristic analyses were used to explore which behaviours can be used to reliably link personal robbery offences using samples provided by two police forces (one urban and one rural). The method of generating unlinked pairs was then refined to reflect how the police work at a local level, and the success of predictive factors re-tested. This research provided evidence supporting the assumptions with linked pairs displaying more similarity than unlinked pairs across a range of behavioural domains. Inter- Crime Distance and Target Selection emerged as the most useful linkage factors with promising results also found for Temporal Proximity and Control. No evidence was found to indicate that either the Approach used or the Property stolen were useful for linkage. The addition of extra behaviours into domains improved performance in some instances but not substantially. The potential impact of group offending on the assumptions was also tested. Although there were some differences found between group and lone robberies, the research demonstrated that case linkage remains feasible provided that the offences under examination are either group or lone in nature rather than a mixture of the two. A supplementary study gathering the views and experiences of police crime analysts regarding case linkage helped put these new quantitative findings into operational context.
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Yu, Junjie, and 于俊杰. "Phylogenetic tree reconstruction with protein linkage." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49618167.
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Phylogenetic tree reconstruction for a set of species is an important problem for understanding the evolutionary history of the species. Existing algorithms usually represent each species as a binary string with each bit indicating whether a particular gene/protein exists in the species. Given the topology of a phylogenetic tree with each leaf representing a species (a binary string of equal length) and each internal node representing the hypothetical ancestor, the Fitch-Hartigan algorithm and the Sankoff algorithm are two polynomial-time algorithms which assign binary strings to internal nodes such that the total Hamming distance between adjacent nodes in the tree is minimized. However, these algorithms oversimplify the evolutionary process by considering only the number of protein insertions/deletions (Hamming distance) between two species and by assuming the evolutionary history of each protein is independent.
Since the function of a protein may depend on the existence of other proteins, the evolutionary history of these functionally dependent proteins should be similar, i.e. functionally dependent proteins should usually be present (or absent) in a species at the same time. Thus, in addition to the Hamming distance, the protein linkage distance for some pairs/sets of proteins: whole block linkage distance, partial block linkage distance, pairwise linkage distance is introduced. It is proved that the phylogenetic tree reconstruction problem to find the binary strings for the internal nodes of a phylogenetic tree that minimizes the sum of the Hamming distance and the linkage distance is NP-hard.
In this thesis, a general algorithm to solve the phylogenetic tree reconstruction with protein linkage problem which runs in O(4^m⋅n) time for whole/partial block linkage distance and O(4^m⋅⋅ (m+n)) time for pairwise linkage distance (compared to the straight-forward O(4^m⋅ m⋅ n) or O(4^m⋅ m^2⋅⋅ n) time algorithm) is introduced where n is the number of species and m is the length of the binary string (number of proteins). It is further shown, by experiments, that our algorithm using linkage information can construct more accurate trees (better matches with the trees constructed by biologists) than the algorithms using only Hamming distance.published_or_final_version
Computer Science
Master
Master of Philosophy
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Jia, Fei. "FDI linkage : impacts, determinants, and policies." Thesis, University of Surrey, 2007. http://epubs.surrey.ac.uk/724/.
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O'Neill, Francis Anthony. "Chromosome and linkage studies in schizophrenia." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334473.
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Medlar, A. J. "Manycore algorithms for genetic linkage analysis." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1366896/.
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Exact algorithms to perform linkage analysis scale exponentially with the size of the input. Beyond a critical point, the amount of work that needs to be done exceeds both available time and memory. In these circumstances, we are forced to either abbreviate the input in some manner or else use an approximation. Approximate methods, like Markov chain Monte Carlo (MCMC), though they make the problem tractable, can take an immense amount of time to converge. The problem of high convergence time is compounded by software which is single-threaded and, as computer processors are manufactured with increasing numbers of physical processing cores, are not designed to take advantage of the available processing power. In this thesis, we will describe our program SwiftLink that embodies our work adapting existing Gibbs samplers to modern computer processor architectures. The processor architectures we target are: multicore processors, that currently feature between 4–8 processor cores, and computer graphics cards (GPUs) that already feature hundreds of processor cores. We implemented parallel versions of the meiosis sampler, that mixes well with tightly linked markers but suffers from irreducibility issues, and the locus sampler which is guaranteed to be irreducible but mixes slowly with tightly linked markers. We evaluate SwiftLink’s performance on real-world datasets of large consanguineous families. We demonstrate that using four processor cores for a single analysis is 3–3.2x faster than the single-threaded implementation of SwiftLink. With respect to the existing MCMC-based programs: it achieves a 6.6–8.7x speedup compared to Morgan and a 66.4– 72.3x speedup compared to Simwalk. Utilising both a multicore processor and a GPU performs 7–7.9x faster than the single-threaded implementation, a 17.6–19x speedup compared to Morgan and a 145.5–192.3x speedup compared to Simwalk.
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MacGregor, Stuart. "Genetic linkage mapping in complex pedigrees." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/12507.
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Genetic linkage analysis is the primary method for the identification of loci contributing to complex disease susceptibility. Linkage analysis techniques can be applied to both disease status (discrete traits) and to quantitative trait measures (quantitative trait loci or QTL mapping). Such techniques will be most effective if they can be applied to all of the available data; in human, ecological and livestock genetics this often means families with complex pedigree structures. The analysis of complex pedigrees is more difficult, both in terms of model formulation and computational ease, than similar studies of small family structures such as affected sibling pairs (ASP). Univariate variance component (VC) techniques suitable for QTL analysis of both quantitative and qualitative (via a threshold model) traits are described. Extensions to the univariate VC methods are proposed, allowing QTL analyses of longitudinal data in complex pedigrees, with polynomial based covariance functions offering a parsimonious description of the covariance structure across measures. Computer simulations are used to show that, under a range of realistic scenarios, the longitudinal QTL method offers more power to detect QTL than univariate or repeated measures methods. The longitudinal method is subsequently applied to a 330 extended families from the Framingham Heart Study, allowing the identification of QTL for a number of cardiovascular disease risk factors. The maximum LOD score (3.12) is obtained on chromosome 16 for Body Mass Index (BMI) and subsequent multivariate analyses showed that this QTL is most relevant to BMI at early ages. Threshold model based VC and parametric linkage analyses are applied to a set of Scottish families affected by psychiatric disease. The results from this analysis are in agreement with previous results implicating chromosome 1q42 in psychiatric disease susceptibility. The broad application of the VC techniques is further demonstrated by applying the techniques to a QTL mapping problem in a very large Red Deer (Cervus Elaphus) pedigree.
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Wahlberg, Per. "Chicken Genomics - Linkage and QTL mapping." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9502.
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Biswas, Swati. "On incorporating heterogeneity in linkage analysis." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1070468056.
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Thesis (Ph. D.)--Ohio State University, 2003.Title from first page of PDF file. Document formatted into pages; contains xii, 123 p.; also includes graphics. Includes abstract and vita. Advisor: Shili Lin, Dept. of Statistics. Includes bibliographical references (p. 119-123).
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Alsabban, Shaza. "Whole genome linkage analysis in a large multigenerational family from Brazil and case control exploration of linkage regions." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/whole-genome-linkage-analysis-in-a-large-multigenerational-family-from-brazil-and-case-control-exploration-of-linkage-regions(c54791d5-6782-4b32-b121-def3b3acdb41).html.
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Substantial evidence from family and twin studies confirms the importance of genes in influencing susceptibility to Bipolar Disorder (BPD) and Depression. Genome- wide association studies have uncovered a few genetic variants of small effect that explain only a fraction of the total heritability of these disorders, and linkage studies have not been able to identify consistent and replicable findings, possibly due to phenotypic complexity and genetic heterogeneity. Large multigenerational families work as powerful samples to mapping loci for complex diseases as they segregate fewer disease causing genes than a collection of independent nuclear families. These fewer genes segregating may also be more highly penetrant and easier to detect in linkage studies. This study performed a whole genome linkage scan of a large multigenerational family from Brazil segregating a severe form of BPD and unipolar depression with the aim of localising and identifying genetic variants that contribute to the development of BPD. The ‘Brazilian Bipolar Family’ (BBF) is one of the largest reported in the literature. Three hundred and eight family members were interviewed using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) and the Kiddie-SADS-Present and Lifetime Version (K-SADS-PL) and three- hundred and twenty-four family members were genotyped using the Affymetrix 10K array. Parametric and non-parametric linkage analyses were performed using four hierarchical phenotype models. Four genome-wide significant linkage regions were identified on chromosomes 2p23.1-p22.3, 3p24.3-p24.1, 11p15.4, and 12q24.22- q24.32, and four suggestive linkage regions were identified on chromosomes 1p22.2- p21.3, 1q21.1-q21.3, 12p13.32-p13.31, and 22q11.21-q12.1, which either conferred specific risk to BPD, unipolar depression, or provided evidence for a general mood disorder liability. To determine the role of the identified linkage regions in sporadic bipolar and depression cases, I performed a case control association analysis using bipolar and depression case control cohorts. None of the linkage regions identified in the BBF were found to be associated with BPD or depression. The future aim of this project is to determine the functional variants within the identified linkage regions that may be contributing to the development of mood disorders in the BBF through sequencing analysis, which is already underway.
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Damkaci, Fehmi. "Methods for stereoselective synthesis of glycopyranosylamide linkage." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/21.
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Thesis (Ph.D.) -- University of Maryland, College Park, 2004.Thesis research directed by: Chemistry. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Huynh, Tony. "The Linkage Problem for Group-labelled Graphs." Thesis, University of Waterloo, University of Waterloo, 2009. http://hdl.handle.net/10012/4716.
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This thesis aims to extend some of the results of the Graph Minors Project of Robertson and Seymour to "group-labelled graphs". Let $\Gamma$ be a group. A $\Gamma$-labelled graph is an oriented graph with its edges labelled from $\Gamma$, and is thus a generalization of a signed graph.
Our primary result is a generalization of the main result from Graph Minors XIII. For any finite abelian group $\Gamma$, and any fixed $\Gamma$-labelled graph $H$, we present a polynomial-time algorithm that determines if an input $\Gamma$-labelled graph $G$ has an $H$-minor. The correctness of our algorithm relies on much of the machinery developed throughout the graph minors papers. We therefore hope it can serve as a reasonable introduction to the subject.
Remarkably, Robertson and Seymour also prove that for any sequence $G_1, G_2, \dots$ of graphs, there exist indices $i
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Dai, Yamei. "Linkage and association analysis in multiple sclerosis /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-020-2/.
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Ramirez, Issa A. "Linkage-based prosthetic fingertips : analysis and testing." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002273.
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Dyment, David Alexandre. "Linkage and association studies in multiple sclerosis." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408689.
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Ruddy, Deborah Marie. "Linkage studies in familiar motor neurone disease." Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420083.
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Peacock, David Charles Peter. "Displacement and segment linkage in fault zones." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305893.
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Ngong, Chiano Mathias. "Statistical problems in human genetic linkage analysis." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339750.
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Sawcer, Stephen James. "A linkage genome screen in multiple sclerosis." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627121.
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Dare, Emmanuel. "Political parties and democratic linkage in Nigeria." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=205388.
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Carlson, Stephen O. "Adaptive control of a four-bar linkage." Thesis, Virginia Tech, 1985. http://hdl.handle.net/10919/45586.
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Three discrete-time adaptive controllers are developed and applied to Four-bar linkage velocity control to reduce the input link velocity fluctuations without compromising the control system velocity transient response. The successful control techniques use the known mechanism kinematics and the mechanism input link position to control the nonlinear mechanism dynamics. The study shows that the adaptive controls are feasible to implement using current microprocessor technology, and the velocity control performance is improved when compared to an industry-standard analog servomotor control. However, more development is required to realize the full potential of the adapative control technique.
A nonlinear Four-bar dynamic model is developed using Kinematic Influence Coefficients. This model is used to develop the adaptive controls and to computer simulate the control scheme performances. The simulated model velocity response is compared qualitatively to experimental data and shown to be similar to an experimental device.
Master of Science
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XING, CHAO. "TOPICS IN MULTIPOINT LINKAGE AND ASSOCIATION ANALYSIS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1164739005.
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Thompson, Cheryl L. "STRATIFIED LINKAGE ANALYSIS BASED ON POPULATION SUBSTRUCTURE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1175867246.
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Veroneze, Renata. "Linkage disequilibrium and genomic selection in pigs." Universidade Federal de Viçosa, 2015. http://www.locus.ufv.br/handle/123456789/7597.
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A seleção genômica (SG) e associação genômica ampla (GWAS) são métodos que exploram o desequilíbrio de ligação (LD) entre marcadores e loci de características quantitativas (QTL). Um dos fatores limitantes para a implementação da SG é a necessidade de um grande número de animais genotipados e fenotipados para obtenção de valores genéticos com alta acurácia. Essa limitação pode ser superada combinando dados de múltiplas populações ou utilizando dados de animais cruzados. O objetivo geral desta tese foi caracterizar os padrões de LD de diferentes populações de suínos. Além disso, avaliar em que medida as diferenças de LD se refletem na acurácia da seleção genômica quando utilizadas diferentes metodologias e arranjos para população de referência e validação. Os arranjos testados foram: utilização de subconjuntos da mesma população como referência e validação (within), populações diferentes nos conjuntos de referência e validação (across) e combinação de duas populações na referência (multi). Nessa tese foram utilizados dados de suínos de linhas puras e de animais cruzados, genotipados com o PorcineSNP60 BeadChip. A regressão Loess proporcionou melhor ajuste aos dados de LD, bem como em predições mais acuradas em comparação a regressão não linear. Mostrou-se também, que a regressão Loess pode ser utilizada para realizar uma comparação estatística do LD decay de diferentes populações. A persistência de fase do LD entre animais cruzados e as linhas puras parentais foi alta, o que nos leva a hipotetizar que associações marcador-QTL similares poderiam ser encontradas em animais cruzados e as linhas parentais e, portanto, esperava-se encontrar altas acurácias de predição genômica entre essas populações. Entre as linhas puras a persistência de fase foi baixa, logo painéis de SNPs de maior densidade deveriam ser utilizados para manter a mesma associação marcador-QTL entre essas linhas. Acurácias obtidas na predição genômica utilizando animais cruzados assim como os arranjos across e multi, não seguiram as expectativas baseadas em LD. Portanto, a consistência de fase de ligação entre populações pode não ser tão importante para a acurácia da seleção genômica como se pensava, mas sim a ação combinada de LD, arquitetura genética e frequências alélicas. Portanto, foi desenvolvida uma metodologia que leva em consideração differenças nas frequências alélicas, bem como informações dos GWAS para comtemplar a arquitetura genética da característica. Esta estratégia trouxe alguns benefícios para a predição genônima para os arranjos within e multi. Ponderações obtidas por meio de GWAS em diferentes conjuntos de dados (uma única população e combinando múltiplas populações) nem sempre resultou em aumento da acurácia, sendo dependente da linha que estava sob seleção. O uso de pesos advindos do GWAS ao se utilizar uma população combinada resultou nas melhores acurácias tanto para os arranjos within quanto multi. A avaliação e o entendimento de como diferenças de LD, frequências alélicas e arquitetura genética afetam a acurácia da predição genômica é fundamental para otimizar a inserção da seleção genômica no melhoramento de suínos.
Genomic selection and genomic wide association studies (GWAS) are widely used methods that aim to exploit the linkage disequilibrium (LD) between markers and quantitative trait loci (QTL). Securing a sufficiently large set of genotypes and phenotypes can be a limiting factor when implementing genomic selection that may be overcome by combining data from multiple populations or using crossbred information. The overall objective of this thesis was to characterize LD patterns in different pig populations and to evaluate whether the differences in LD determine the accuracy of genomic predictions when using different reference sets (within-, across- and multi- population) and methodologies. In this thesis I used data from pure lines and crossbred pig populations genotyped with PorcineSNP60 BeadChip. Loess regression provided a better fit to the real LD data, and more accurate LD predictions could be made, compared to nonlinear regression. It was also shown that Loess regression can be used to statistically compare the LD decay of different populations. The persistence of LD phase between crosses and the parental pig lines was found to be high, from which it was hypothesized that similar marker-QTL associations would be found in a cross and in their purebred parent populations and therefore accuracies of genomic prediction across these populations should be high. Between the pure lines the persistence of phase was low, thus higher density panels should be used to have the same marker-QTL associations across these lines. Accuracies obtained from across- and multi-population genomic prediction and from using crossbred data did however not follow the expectations based on LD. Having the same LD phase may therefore not be as important for genomic prediction accuracy as previously thought but rather the interplay between LD, genetic architecture and allele frequencies also plays a major role. Differences in allele frequencies between lines and information from GWAS on the genetic architecture of traits for the different lines were taken into account in analyses developed in the later chapters. The use of weights, based on GWAS results, was expected to lead the GBLUP model towards the real genetic architecture of the traits. This strategy was shown to have some benefit for the genomic predictions with single- and multi-population data sets. Weights obtained from GWAS in different data sets (within and combining populations) did not always lead to increased accuracies of prediction, depending on which lines the weights are applied to. Using weights from GWAS in a combined population was the best approach, resulting in higher accuracy of GBLUP predictions within single- as well as in multi-population analysis. Understanding and evaluating how the accuracy of within-, across- and multi-population genomic prediction is affected by differences in LD, in genetic architecture and in allele frequencies is key to optimize the accuracy of genomic prediction in pig breeding.
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Wong, León Kevin, and Valdivia Diego Eduardo Antonio Rodríguez. "Distributed Social Media System - Multimedia Data Linkage." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2014. http://hdl.handle.net/10757/324525.
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Actualmente, las redes sociales en línea son uno de los principales medios donde se intercambia gran cantidad de información. En estas, los usuarios intentan reflejar su actividad diaria en forma de publicaciones en sus muros o de otros usuarios. Asimismo, las imágenes representan gran parte de la información sobre la actividad del usuario, por ejemplo, una foto en donde esté etiquetado. Estas interacciones del usuario en las redes ayudan a generar su identidad digital. La información revelada por la metadata de las imágenes enriquece este perfil y contribuye a mejorar los resultados en procesos como minería de datos, marketing, etc. El objetivo de este proyecto es generar un perfil digital en base a la información y actividad que contribuye un usuario a una red social, recopilando y mostrando explícitamente varios hechos que se revelan aprovechando la metadata de las imágenes y el factor temporal de la actividad en línea. Esto incluye el proceso de extracción, enriquecimiento y encapsulación de data en un modelo ontológico propuesto. Los resultados de los experimentos muestran que la información en el perfil, luego del enriquecimiento, es aproximadamente cuatro veces la información inicial, y la precisión de la nueva información está por encima del 75%. Trabajos futuros se inclinan hacia la detección del tipo de relación que existe entre una persona y uno de sus contactos. Asimismo, otro tema relevante a explorar incluye la extracción de un mayor rango de entidades, tales como eventos o temas de interés de un individuo, con el fin de mejorar el perfil digital del usuario. Finalmente, la minería de datos en el proceso de extracción de información ayudaría a enfocar mejor el marketing a los usuarios de redes sociales ya que dicha publicidad podría hacerse más personalizada. Palabras clave Linked data, información multimedia, perfil digital, redes sociales, metadataTesis
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Almestiri, Saleh Mohamed. "The Dual of SU(2) in the Analysis of Spatial Linkages, SU(2) in the Synthesis of Spherical Linkages, and Isotropic Coordinates in Planar Linkage Singularity Trace Generation." University of Dayton / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1524241477831728.
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Welford, John Anthony. "Nominal record linkage : the development of computer strategies to achieve the family-based record linkage of nineteenth century demographic data." Thesis, n.p, 1989. http://ethos.bl.uk/.
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Boyd, James Hutchison. "Record Linkage Techniques: Exploring and developing data matching methods to create national record linkage infrastructure to support population level research." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/54163.
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In a world where the growth in digital information and systems continues to expand, researchers have access to unprecedented amounts of data. These large and complex data reservoirs require creative, innovative and scalable tools to unlock the potential of this ‘big data’. Record linkage is a powerful tool in the ‘big data’ arsenal. This thesis demonstrates the value of national record linkage infrastructure and how this has been achieved for the Australian research community.
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Nin, Guerrero Jordi. "Contributions to Record Linkage for Disclosure Risk Assessment." Doctoral thesis, Universitat Autònoma de Barcelona, 2008. http://hdl.handle.net/10803/5787.
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Cada dia una gran quantitat de dades són recollides pels instituts d'estadística. Aquest fet combinat amb el creixement que ha experimentat Internet en els darrers anys fa que hom es pregunti si les seves dades confidencials són emmagatzemades i distribuïdes d'una manera privada i segura.En aquest marc, els mètodes de protecció de dades tenen una gran importància, convertint-se en crucial anonimitzar les dades abans de la seva publicació. Quan anonimitzem un conjunt de dades amb un mètode de protectió, s'ha d'avaluar el grau de privadesa de les noves dades protegides. Les tècniques de re-identificació, com l'enllaç de registres, són unes de les tècniques més utilitzades per avaluar la seguretat d'un mètode de protecció.
Aquesta tesi aplica mètodes d'enllaç de registres al càlcul del risc de revelació dels diferents mètodes de protecció de dades. L'objectiu d'aquest procés és avaluar la seguretat d'un mètode de protecció d'una forma pràctica i real. Les principals contribucions d'aquesta tesis són:
· La definició de tres mètodes d'enllaç de registres dissenyats per avaluar el risc de revelació de dos dels mètodes d'anonimització més utilitzats: la microagregació i l'intercanvi de rangs.
· La formalització d'una mesura empírica que avalua el risc de revelació de la microagregació multi variable.
· El desenvolupament de noves variants dels mètodes de protecció clàssics que són resistents a les tècniques d'enllaç de registres definides dins d'aquesta tesi.
· L'estudi de nous escenaris on el risc de revelació encara existeix. Concretament, hem definit un mètode de re-identificació basat en funcions d'agregació que permet re-identificar individus quan l'intrús no té accés a les dades originals abans d'ésser protegides. També hem desenvolupat un marc per a l'avaluació de mètodes de protecció quan aquests s'apliquen a series temporals. En aquest darrer escenari hem definit una serie de mesures per avaluar la pèrdua d'informació i el risc de revelació.
Every day, a large amount of data is collected by statistical agencies. This fact combined with the growth that the Internet has experimented during the recent years makes one wonders whether its confidential data is stored and distributed in a secure way.
In this framework, data protection methods have a great importance, becoming crucial to anonymize confidential attributes before releasing them in a private and secure manner. When a protection method is applied, a new and challenging problem arises. This problem is the evaluation of the privacy provided by such method. Re-identification techniques, as record linkage methods, are one of the most common techniques for evaluating the security of a protection method.
This thesis applies record linkage techniques to the calculation of the disclosure risk of a protection method. The aim of this application is to evaluate the security of a protection method in a real and fair way. The main contributions are:
· The definition of three specific record linkage techniques for evaluating two of the most common protection methods: rank swapping and microaggregation.
· The definition of an empirical disclosure risk measure for microaggregation.
· The development of new variants of rank swapping and microaggregation resistant to record linkage methods and disclosure risk measures defined in this thesis.
· The study of new disclosure risk scenarios. In particular, we have developed a record linkage method which applies aggregation functions to re-identify individuals when the intruder has no access to any of the original attributes of the protected data. We have also developed a framework for the evaluation of protection methods when they are applied to time series data.
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Zenger, Kyall Richard. "Genetic linkage maps and population genetics of macropods." Phd thesis, Australia : Macquarie University, 2002. http://hdl.handle.net/1959.14/47604.
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"November 2001".Thesis (PhD)--Macquarie University, Division of Environmental and Life Sciences, Department of Biological Sciences, 2002.
Bibliography: leaves 136-157.
General introduction -- Molecular markers for comparative and quantitative studies in macropods -- Genetic linkage map construction in the tammar wallaby (M. eugenii) -- Intraspecific variation, sex-biased dispersal and phylogeography of the eastern grey kangaroo (M. giganteus) -- General discussion.
The analysis of DNA using molecular techniques is an important tool for studies of evolutionary relationships, population genetics and genome organisation. The use of molecular markers within marsupials is primarily limited by their availability and success of amplification. Within this study, 77 macropodid type II microsatellite loci and two type I genetic markers were characterised within M. eugenii to evaluate polymorphic levels and cross-species amplification artifacts. Results indicated that 65 microsatellite loci amplified a single locus in M. eugenii with 44 exhibiting high levels of variability. The success of crossspecies amplification of microsatellite loci was inversely proportional to the evolutionary distance between the macropod species. It is revealed that the majority of species within the Macropodidae are capable of using many of the available heterologous microsatellites. When comparing the degree of variability between source-species and M. eugenii, most were significantly higher within source species (P < 0.05). These differences were most likely caused by ascertainment bias in microsatellite selection for both length and purity. -- The production of a marsupial genetic linkage map is perhaps one of the most important objectives in marsupial research. This study used a total of 353 informative meioses and 64 genetic markers to construct a framework genetic linkage map for M. eugenii. Nearly all markers (93.7%) formed a significant linkage (LOD > 3.0) with at least one other marker. More than 70% (828 cM) of the genome had been mapped when compared with chiasmata data. Nine linkage groups were identified, with all but one (LG7; X-linked) allocated to the autosomes. Theses groups ranged in size from 15.7 cM to 176.5 cM, and have an average distance of 16.2 cM between adjacent markers. Of the autosomal linkage groups, LG2 and LG3 were assigned to chromosome 1 and LG4 localised to chromosome 3 based on physical localisation of genes. Significant sex-specific distortions towards reduced female recombination rates were revealed in 22% of comparisons. Positive interference was observed within all the linkage groups analysed. When comparing the X-chromosome data to closely related species it is apparent that it is conserved both in synteny and gene order. -- The investigation of population dynamics of eastern grey kangaroos has been limited to a few ecological studies. The present investigation provides analysis of mtDNA and microsatellite data to infer both historical and contemporary patterns of population structuring and dispersal. The average level of genetic variation across sample locations was exceedingly high (h = 0.95, HE = 0.82), and is one of the highest observed for marsupials. Contrary to ecological studies, both genic and genotypic analyses reveal weak genetic structure of populations where high levels of dispersal may be inferred up to 230 km. The movement of individuals was predominantly male-biased (average N,m = 22.61, average N p = 2.73). However, neither sex showed significant isolation by distance. On a continental scale, there was strong genetic differentiation and phylogeographic distinction between southern (TAS, VIC and NSW) and northern (QLD) Australian populations, indicating a current and / or historical restriction of geneflow. In addition, it is evident that northern populations are historically more recent, and were derived from a small number of southern eastern grey kangaroo founders. Phylogenetic comparisons between M. g. giganteus and M. g. tasmaniensis, indicated that the current taxonomic status of these subspecies should be revised as there was a lack of genetic differentiation between the populations sampled.
Mode of access: World Wide Web.
xv, 182 leaves ill
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Loredo-Osti, J. Concepción. "Analysis of quantitative traits, segregation and conditional linkage." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0015/NQ49278.pdf.
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Qiao, Guirong. "Unification of planar linkage synthesis through kinematic mapping." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19577.
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A general treatment which includes special cases of the five poses planar four-bar synthesis problem is investigated. There are 0, 2, or 4 real solutions to this problem formulated with five simultaneous equations. This method exposes solutions containing RR, PR, or RP dyads. The kinematic mapping is used to represent planar constraint equations in a three-dimensional projective image space because it offers a comprehensive way to solve problems in kinematic synthesis. The motion of a planar rigid body under a RR constraint can be mapped to points on a skew one-sheet hyperboloid with circles as generators which are generated by intersecting the hyperboloid with planes parallel to X3 = 0 in the image space. Similarly, a RP or PR dyad generates points on a unique hyperbolic paraboloid ruled by lines when intersected with planes parallel to X3 = 0. The five-pose four-bar linkage synthesis problem leads to five second-order constraint equations. By solving the constraint equations for RR dyads or four constraint equations for a RP or a PR dyad, four-bar linkage design parameters can be computed. In this thesis, examples which produce two RR dyads, four RR dyads and one RR dyad with one RP dyad will be analyzed. Furthermore, an approximate solution, with kinematic mapping, is given to the planar elliptical trammel synthesis problem.
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Cooper, Anneli Clare. "Linkage mapping and genetic analysis of Trypanosoma brucei." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/1656/.
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Trypanosoma brucei is a protozoan parasite of major public health and economic importance in sub-Saharan Africa, where it is the causative agent of sleeping sickness in man and Nagana in cattle. The complete genome sequence of T.brucei is now available and the diploid genetic system has recently been demonstrated to be Mendelian. This opens up the possibility of using a classical genetic approach to identify genetic loci that determine important phenotypic traits in this parasite, such as host specificity, drug resistance, and pathogenicity. A genetic map of the non human-infective subspecies, T.b.brucei, has already been assembled and successfully used in quantitative trait analysis of a number of traits specific to this pathogen. This thesis describes the construction of a separate genetic map for the sub-species responsible for > 90% of human African trypanosomiasis infections, T.b.gambiense, which differs significantly from T.b.brucei in many key phenotypes. The genetic linkage map was constructed from the analysis of 119 polymorphic microsatellite markers in a population of 38 F1 progeny, obtained from the genetic cross of a T.b.gambiense group 2 strain, STIB 386, with a T.b.brucei strain, STIB 247. Eleven major linkage groups were resolved, one for each of the megabase chromosomes, resulting in a total genetic map length of 733 cM, and an average map unit size of 24 Kb/cM. The map provides a 90% probability of a marker being within 268 Kb of any genetic locus. A comparative analysis of the T.b.gambiense and T.b.brucei genetic maps revealed synteny and marker order to be conserved between the two sub-species. However, variation was observed in the location of regions of high and low recombination frequency (hot and cold spots) in the two maps. The genetic linkage map presented here is the first available for T.b.gambiense and can now be utilised to find the location within the genome of genes responsible for phenotypic traits in this clinically important sub-species. These traits include human infectivity, tsetse transmissibility and virulence, in addition to sensitivity to the trypanocidal drug, pentamidine, for which phenotypic variation between the parents was characterised both in vitro and in vivo in this thesis. The ability of the T.brucei genetic maps to pinpoint loci underlying phenotypic variation is limited by the number of recombination events, and therefore progeny, available for analysis. To increase the utility of this approach for future studies, an improved method for progeny isolation from uncloned genetic cross populations was also developed. This in vitro bloodstream cloning procedure is scalable and efficient, and replaces a time consuming and technically demanding in vivo method. Twelve new progeny clones were isolated by this approach during the trial and incorporated into the analysis, representing a step toward a higher resolution second-generation genetic map. Finally, whilst undertaking genotyping analysis with microsatellite markers the development of spontaneous chromosome 10 abnormalities was observed. A detailed investigation identified seven laboratory-adapted T.brucei lines in which loss of heterozygosity appeared to have occurred. These alterations to the karyotype significantly exceeded the well-characterised genomic rearrangements of subtelomeric regions that are frequently associated with antigenic variation in African trypanosomes. Microsatellite analysis, pulsed field gel electrophoresis and Illumina next generation sequencing demonstrated these changes to be the product of mitotic recombination events in the chromosome core, resulting in an extensive loss of heterozygosity of up to 75% of the chromosome and correlated with an improved growth phenotype. Further work is now required to determine the extent and frequency with which these abnormalities might occur, however these findings do highlight the potential instability of the molecular karyotype of T.brucei in prolonged in vitro culture.
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Tonkin, Matthew James. "Behavioural case linkage : generalisability, ecological validity, and methodology." Thesis, University of Leicester, 2012. http://hdl.handle.net/2381/27620.
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Behavioural case linkage (BCL) is a procedure that can be used to identify linked crime series, which contain two or more crimes committed by the same person, thereby helping the police to detect and prosecute repeat offenders who are responsible for a disproportionate amount of crime. However, despite the potential benefits of BCL, there are also damaging consequences if crimes are incorrectly linked. Consequently, research has started to test if and how this procedure can work in the most efficient and reliable way. But, the extant literature has a number of important limitations, particularly in terms of (1) generalisability (i.e., there have been few attempts to replicate findings across geographical locations and time periods), (2) ecological validity (i.e., the methodology used to test BCL is not representative of how the procedure is used in practice), and (3) methodology (i.e., there is a lack of research to systematically compare the various methodological/statistical approaches to BCL). The primary aim of this thesis was to address these three important limitations. In terms of generalisability, this thesis has tested the extent to which previous BCL research on residential burglary, commercial robbery, and car theft can be replicated in new geographical locations and time periods. In terms of ecological validity, a number of new methodologies have been developed and tested that reduce the gap between research and practice in BCL by allowing both non-serial and unsolved offences (as well as solved, serial offences) to be included when testing the principles of BCL, and also for these principles to be tested with crime series that contain several different types of offence. In terms of methodology, novel methodological approaches have been compared with the ‘traditional’, status quo methodology for researching the BCL principles, thereby ensuring that the findings reported in this thesis can be compared with previous work. This thesis, therefore, has important implications for theory, research, and practice and the findings are discussed in the context of these. Future research directions are also outlined.
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盧莊怡 and Jong-yee Joyce Lo. "Edge-linkage-development at Causeway Bay Typhoon Shelter." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31986663.
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