Relevant bibliographies by topics / Lilies Genetics

Academic literature on the topic 'Lilies Genetics'

Author: Grafiati
Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Lilies Genetics"

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Bale, Allen E. "Sheep, lilies and human genetics." Nature 406, no. 6799 (August 2000): 944–45. http://dx.doi.org/10.1038/35023197.

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Do, Hoang Dang Khoa, Changkyun Kim, Mark W. Chase, and Joo‑Hwan Kim. "Implications of plastome evolution in the true lilies (monocot order Liliales)." Molecular Phylogenetics and Evolution 148 (July 2020): 106818. http://dx.doi.org/10.1016/j.ympev.2020.106818.

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Kong, Ying, Ming Sun, Hui-tang Pan, and Qi-xiang Zhang. "Composition and Emission Rhythm of Floral Scent Volatiles from Eight Lily Cut Flowers." Journal of the American Society for Horticultural Science 137, no. 6 (November 2012): 376–82. http://dx.doi.org/10.21273/jashs.137.6.376.

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Floral scents emitted from eight cultivars of cut lily flowers (Lilium) were analyzed. Floral volatiles were collected by headspace adsorption on sorbent tubes and analyzed by gas chromatography–mass spectrometry (GC/MS) using a direct thermal desorption. Fifty volatile compounds were identified. Nine compounds were detected in all lilies, whereas 20 compounds were detected in all scented lilies. The results revealed that non-scented lilies emitted trace amounts of volatile compounds, whereas scented lilies emitted high levels of volatile compounds. Monoterpenoids and benzenoids were the dominant compound classes of volatiles emitted from scented lilies. Myrcene, (E)-β-ocimene, linalool, methyl benzoate, and ethyl benzoate were the major compounds of the aroma of scented lilies; 1,8-cineole was also a major compound in the two scented oriental × trumpet hybrid lilies. Scent emissions occurred in a circadian rhythm with higher levels of volatiles emitted during the night. Lilium ‘Siberia’ was selected as a model to investigate the source of the emissions. GC/MS analysis of four flower parts and neutral red staining revealed that tepals were the source of floral scent.
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Marasek-Ciolakowska, Agnieszka, Tomotaro Nishikawa, Daniel J. Shea, and Keiichi Okazaki. "Breeding of lilies and tulips—Interspecific hybridization and genetic background—." Breeding Science 68, no. 1 (2018): 35–52. http://dx.doi.org/10.1270/jsbbs.17097.

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Bailey, Douglas A., and William B. Miller. "Whole-plant Response of Easter Lilies to Ancymidol and Uniconazole." Journal of the American Society for Horticultural Science 114, no. 3 (May 1989): 393–96. http://dx.doi.org/10.21273/jashs.114.3.393.

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Abstract All growth retardant treatments (ancymidol, 50 mg·liter−1, one or two sprays; uniconazole, 5, 10, or 15 mg·liter−1, one or two sprays; 20 mg·liter−1, one spray) reduced Easter lily (Lilium longiflorum Thunb.) plant heights when compared to controls. Plant heights decreased linearly with increasing concentration of uniconazole for both one- and two-spray treatments. High concentrations of uniconazole delayed anthesis; ancymidol treatments did not. Individual corolla length was not affected by treatments. Treatments did not affect daughter bulb depletion or new daughter bulb growth. Total leaf area and leaf dry weight decreased as uniconazole concentration increased; ancymidol treatments did not affect leaf area, but did reduce leaf dry weight. Leaf total soluble carbohydrate decreased with increasing concentration of uniconazole. Chemical names used: α-cyclopropyl-α-(4-methoxyphenyl)-5-pyrimidine-methanol (ancymidol); (E)-1-(p-chlorophenyI)-4,4-dimethyl-2-(1,2,4-triazol-1-yl)-1-penten-3-ol (uniconazole).
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van der Meulen-Muisers, José J. M., Joop C. van Oeveren, and Jaap M. van Tuyl. "Genotypic Variation in Postharvest Flower Longevity of Asiatic Hybrid Lilies." Journal of the American Society for Horticultural Science 123, no. 2 (March 1998): 283–87. http://dx.doi.org/10.21273/jashs.123.2.283.

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Genotypic variation in postharvest flower longevity was determined for 63 Asiatic lily hybrids (Lilium L.). The reliability of standardized test conditions for longevity screening was also examined. Improvement of lily flower longevity by breeding appears feasible. Considerable genotypic variation in individual flower longevity was obtained and estimates of the degree of genotypic determination were high. The rank order of the genotypes with respect to individual flower longevity was similar between years using standardized test conditions. Screening results for flowers forced in a growth chamber were similar to those obtained in a greenhouse. No plant traits suitable for indirect selection on flower longevity were detected.
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Luo, Jing, Ruirui Li, Xintong Xu, Hairui Niu, Yujie Zhang, and Caiyun Wang. "SMRT and Illumina RNA Sequencing and Characterization of a Key NAC Gene LoNAC29 during the Flower Senescence in Lilium oriental ‘Siberia’." Genes 12, no. 6 (June 6, 2021): 869. http://dx.doi.org/10.3390/genes12060869.

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Lily (Lilium spp.) is an important cut flower around the world. Flower senescence in lilies is characterized by the wilting and abscission of tepals, which results in a decrease in flower quality and huge economic loss. However, the mechanism underlying flower senescence in lilies is largely unknown. In this study, single-molecule, real-time (SMRT) and Illumina sequencing were carried out in L. oriental ‘Siberia’. Sequencing yielded 73,218 non-redundant transcripts, with an N50 of 3792 bp. These data were further integrated with three published transcriptomes through cogent analysis, which yielded 62,960 transcripts, with an increase in N50 of 3935 bp. Analysis of differentially expressed genes showed that 319 transcription factors were highly upregulated during flower senescence. The expression of twelve NAC genes and eleven senescence-associated genes (SAGs) showed that LoNAC29 and LoSAG39 were highly expressed in senescent flowers. Transient overexpression of LoNAC29 and LoSAG39 in tepals of lily notably accelerated flower senescence, and the promoter activity of LoSAG39 was strongly induced by LoNAC29. This work supported new evidence for the molecular mechanism of flower senescence and provided better sequence data for further study in lilies.
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George, Susan, Pearl Behl, Rhoda deGuzman, Marian Lee, Stefan Rusyniak, Yasuo Hotta, Kazuyuki Hiratsuka, Hisabumi Takase, and Clare Hasenkampf. "Dmc1 fluorescent foci in prophase I nuclei of diploid, triploid and hybrid lilies." Chromosoma 111, no. 2 (July 2002): 96–105. http://dx.doi.org/10.1007/s00412-002-0193-5.

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Straathof, Th P., and H. J. M. Löffler. "Resistance to Fusarium oxysporum at Different Developmental Stages of Asiatic Hybrid Lilies." Journal of the American Society for Horticultural Science 119, no. 5 (September 1994): 1068–72. http://dx.doi.org/10.21273/jashs.119.5.1068.

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Tests for determining resistance to Fusarium oxysporum f.sp. lilii in different developmental stages of Lilium were developed. Under standardized conditions, commercial bulbs, yearling bulbs, scale bulblets, and scales of 16 Asiatic lily cultivars were tested for Fusarium resistance. Disease ratings were analyzed statistically using a threshold model for ordered categorical data. For each cultivar in each stage the resistance level was calculated as the disease severity score (DSS). Disease severity score values of cultivars in the four stages were reproducible between experiments, although some variation in cultivars was found. This variation may be attributed to the origin of plant material. Disease severity score values among cultivars in each developmental stage were correlated with the average DSS over all four stages, although some specific cultivar-stage deviations were found. The scale test is recommended for early selection while the scale bulblet test is recommended as a final check.
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Zhou, Shujun, Lei Zhong, Lu Zhang, Zhenghua Xu, Xuxin Liu, Kehu Li, and Guixue Zhou. "Study on the homology of the genomes of tetraploid Asiatic lilies (Lilium) using FISH." Genome 58, no. 11 (November 2015): 453–61. http://dx.doi.org/10.1139/gen-2015-0057.

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Asiatic lily cultivars, bred by hybridization and (or) chromosome doubling of species of section Sinomartagon of Lilium, are diploid, triploid, or tetraploid, but the homology of the genomes among species of section Sinomartagon and Asiatic lilies remains unclear. In the present research, two tetraploid Asiatic cultivars were analyzed, using 45S rDNA as probe, for their FISH karyotypes and their chromosomal association, anaphase I, telophase II, and pollen viability were surveyed to assess the multivalent segregation. Chromosomal assortment of six progenies of the two tetraploid cultivars were also investigated. The results showed that the tetraploid cultivars had similar FISH karyotypes, they predominantly formed multivalents, and these were equally separated because their anaphase I, telophase II, and pollen viability were similar to those of diploid species. Apart from minor variations, FISH karyotypes of progenies were similar to each other and to their parents. Based on these results and considering the high crossability among species of section Sinomartagon and (or) Asiatic lilies, we concluded that species of section Sinomartagon and their resulting cultivars share a common genome; thus, polyploidy Asiatic lilies are autopolyploid.
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Dissertations / Theses on the topic "Lilies Genetics"

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Ribas, Vargas Gracia Celeste. "Genetic manipulation of Lilium." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445688.

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Sheldon, J. M. "The generation of pattern on the pollen wall of Lilium." Thesis, University of Reading, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371457.

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Núñez, de Cáceres González Francisco Federico. "Genetic manipulation of agronomically important traits in Lilium." Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/14565/.

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The ornamental industry has become an important economic force in recent years, in the UK alone this industry is estimated to be around £2.1 billion, while the international trade is around £60-75 billion (Chandler and Tanaka, 2007). The continued success of the floriculture industry depends on the introduction of new species/cultivars with major alterations in key agronomic characteristics, such as resistance to pathogens, novel flower colour and patterns or control of male fertility. Lilium, one of the most important bulbous ornamental crops, is an attractive and popular cut flower. However, the production of vast quantities of pollen that stains easily and is toxic to animals is not always desirable. The control of pollen release without affecting the appearance of the flower is therefore an important breeding goal. Lilium is also susceptible to several fungal pathogens, including Botrytis cinerea, which infects leaves, stem and flowers leading to a reduction of yield. New cultivars have tended to rely upon selective breeding as a mechanism for trait development. However approaches that utilise transgenes to manipulate traits of interest provide alternative opportunities for the ornamental industry provided that transformation and regeneration can be achieved efficiently. A rapid, highly efficient and reproducible Agrobacterium-mediated transformation for Lilium has been developed. Successful transient GUS expression in callus, shoots and basal plate discs was achieved using A. tumefaciens strain AGL1 containing plasmid pBI121 harbouring intron-containing GUS and NPTII genes in cultivars "Beverly's Dream", "Star Gazer", "Night Flyer", "Acapulco", "Sweet Surrender" and Lilium leichtlinii. Based on the same transformation protocol, transgenic plants of cv. "Star Gazer" overexpressing the RCH10 chitinase gene from rice were generated. In vitro sporulation assays of these plants showed different levels of resistance to Botrytis cinerea correlated to the level of relative expression of the transgene. This is the first report of induced pathogen resistance in any Lilium cultivar by transgenic approach. Experiments were also conducted to modify fertility and pollen release in Lilium by translating regulatory gene information from Arabidopsis to Lilium. Transgenic plants of cv. "Star Gazer" either overexpressing or silencing the AtMYB26 gene, were generated. RNAi lines showed a delay in anther dehiscence suggesting that pollen development pathways could be conserved between Arabidopsis and Lilium. In addition, partial sequences of the putative orthologues of AtMS1 and AtMYB26 in Lilium were identified and cloned for future research.
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Howley, Paul Michael. "The cloning of microsporogenesis and meiosis specific sequences from the meiocyte, microspore and pollen cells of Lilium henryii." Thesis, University of Reading, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332857.

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Pelkonen, V. P. (Veli-Pekka). "Biotechnological approaches in lily (Lilium) production." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514276590.

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Abstract Biotechnology has become a necessity, not only in research, but also in the culture and breeding of lilies. Various methods in tissue culture and molecular breeding have been applied to the production of commercially important lily species and cultivars. However, scientific research data of such species and varieties that have potential in the northern climate is scarce. In this work, different biotechnological methods were developed and used in the production and culture of a diversity of lily species belonging to different taxonomic groups. The aim was to test and develop further the existing methods in plant biotechnology for the developmental work and the production of novel hardy lily cultivars for northern climates. Most of the plant material was started from seeds, which provided genetic variability and new material for breeding. Different features in seed structure were studied with light microscopy and SEM, and different parameters affecting germination were tested. Several tissue culture protocols were also compared with different species using both solid and liquid media. Molecular biological methods were used in assessing genetic background of traditionally grown lilies. Somatic embryogenesis in callus differentiation of callus cultures was studied, and gene expression behind differentiation processes was analyzed with various molecular biological methods. Particle bombardment system was used in genetic transformation. In addition, protoplast isolation methods from various tissues were tested. The main results indicate that many tissue culture methods can be used in research and in mass production with all tested species. Especially in a large-scale production, temporary immersion system is promising. In addition to the conventional bulb scale material, seeds were found to be a suitable starting material for genetic variability required for production of new cultivars, and in the preservation of natural populations. RAPD techniques proved a suitable method for revealing phylogenetic relations of different lily species and cultivars. Methods in DNA and RNA isolation, cloning and analysis were optimized for lily material. In addition, particle bombardment system was successfully used for genetic transformation of lily callus. In the future, more information is needed to understand better the germination and differentiation processes, focusing especially in the genes, their products and function. In addition, the large and still mostly unknown lily genome is a challenge for research in the future. However, the currently presented results provide good opportunities for further developmental work and research of hardy lily species.
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Zugowski, Constance [Verfasser], K. [Akademischer Betreuer] Breunig, H. [Akademischer Betreuer] Lilie, and K. [Akademischer Betreuer] Melcher. "Molecular genetic and biochemical interaction studies of the transcriptional activator Gal4 and its repressor Gal80 in Saccharomyces cerevisiae and Kluyveromyces lactis / Constance Zugowski. Betreuer: K. Breunig ; H. Lilie ; K. Melcher." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2013. http://d-nb.info/1033306649/34.

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O'Leary, Maureen C. "Techniques for genetically engineering lily pollen /." 1992. https://scholarworks.umass.edu/theses/3431.

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JIN, SHI-WEN, and 金石文. "Electrophoretic pattern and genetic analysis of isozymes in lilies and asiatic cultivars." Thesis, 1989. http://ndltd.ncl.edu.tw/handle/97907018971918850729.

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LIU, ZHEN-ZHEN, and 劉蓁蓁. "The incompatibility and genetic markers of the asiatic、longiflorum and oriental hybrids of lilies." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/03365460591827742711.

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Lin, Yi-Yin, and 林怡吟. "The Population Genetic Structure of Lilium longiflorum(." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/35961655958015273645.

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碩士
國立臺灣師範大學
生物學系
84
The population of Lilium longiflorum along eastern coast of Taiwan always occurs in isolated habitats.The population genetic structure of a species which is island distribution like L. longiflorum is a good theme to study.Thirteen population weresampled and genetic variation was investigated using starch gel eletrophoresis.Genetic disversity was rich for the species( Hes=0.191)as well as within population(Hep=0.142).Of the 20 allozyme loci examined,13(65%)were polymorphic,and on average35.38% of the loci were polymorphic within population.The mean number of allelesper locus was 1.61 and the mean effective number of that was 1.17 within population.We found a high proportion of total genetic variation (24%) among population and a significant correlation (p<0.001) between genetic distance and geographic distance.Gene flow and nature selection appear to play major roles in the population structureof the species,while gene folw is more influential than nature selection.
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Books on the topic "Lilies Genetics"

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Fehse, Boris, Ferdinand Hucho, Sina Bartfeld, Stephan Clemens, Tobias Erb, Heiner Fangerau, Jürgen Hampel, et al., eds. Fünfter Gentechnologiebericht. Nomos Verlagsgesellschaft mbH & Co. KG, 2021. http://dx.doi.org/10.5771/9783748927242.

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In the ‘Fifth Gene Technology Report’, renowned experts provide an overview of current developments and their applications in the dynamically evolving research field of gene and biotechnologies. They examine, among other topics, genetic diagnostics, somatic gene therapy, the development of vaccines, stem cell and organoid research, green gene technology, synthetic biology, gene drives, genome editing, epigenetics and single cell analysis. In addition to reporting on the current state of affairs in this field, the authors also discuss society’s perception of gene technologies and ethical and legal issues relating to them, such as genome edit-ing, cerebral organoids and big data in personalised medicine. Moreover, the interdisciplinary task force ‘Gentechnologiebericht’ (Gene Technology Report) offers recommendations on action that could be taken in relation to the key issues. With contributions by Karla Alex, Sina Bartfeld, Meik Bittkowski, Inge Broer, Lorina Buhr, Stephan Clemens, Wolfgang Van den Daele, Hans-Georg Dederer, Tobias J. Erb, Nina Gasparoni, Heiner Fangerau, Boris Fehse, Jürgen Hampel, Louise Herde, Ferdinand Hucho, Ali Jawaid, Aida Khachatryan, Sarah Kohler, Alma Kolleck, Martin Korte, Cordula Kropp, Alfons Labisch, Markus Lehmkuhl, Melanie Leidecker-Sandmann, Annette Leßmöllmann, Isabelle M. Mansuy, Lilian Marx-Stölting, Andreas Merk, Yannick Milhahn, Fruzsina Molnár-Gábor, Stefan Mundlos, Staffan Müller-Wille, Angela Osterheider, Anja Pichl, Barbara Prainsack, Jens Reich, Marlen Reinschke, Ortwin Renn, Hans-Jörg Rheinberger, Arnold Sauter, Hannah Schickl, Silke Schicktanz, Volker Stollorz, Constanze Störk-Biber, Jochen Taupitz, Jörn Walter, Eva C. Winkler, Martin Zenke and Michael M. Zwick.
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Book chapters on the topic "Lilies Genetics"

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Bino, R. J., M. G. M. van Creij, L. M. van der Leede-Plegt, A. J. van Tunen, and J. M. van Tuyl. "Application of in Vitro Pollination and Fertilization Techniques for Breeding and Genetic Manipulation of Lilium." In Sexual Plant Reproduction, 127–34. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77677-9_12.

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"Production Of Doubled Haploids In Oriental Lilies." In Genetic Manipulation in Plant Breeding, 335–38. De Gruyter, 1986. http://dx.doi.org/10.1515/9783110871944-058.

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NODA, SHOZO. "Chromosomal Variation and Evolution in the Genus Lilium." In Developments in Plant Genetics and Breeding, 507–24. Elsevier, 1991. http://dx.doi.org/10.1016/b978-0-444-88260-8.50032-x.

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Azadi, Pejman, Valentine Ntui, Dong Chin, and Masahiro Mii. "Genetic Transformation and Metabolic Engineering of Lilium." In Bulbous Plants, 197–213. CRC Press, 2013. http://dx.doi.org/10.1201/b16136-12.

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"Genetic Transformation and Metabolic Engineering of Lilium." In Bulbous Plants, 205–21. CRC Press, 2016. http://dx.doi.org/10.1201/b16136-13.

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"Lillie's Paradox – Or, Some Hazards of Cellular Geography." In The Epistemology of Development, Evolution, and Genetics, 183–209. Cambridge University Press, 2004. http://dx.doi.org/10.1017/cbo9780511610271.015.

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Conference papers on the topic "Lilies Genetics"

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Pontes, Vitória de Melo, and PEDRO HENRRIQUE SALES DE OLIVEIRA. "PSORÍASE E ANTICORPOS MONOCLONAIS: PERSPECTIVAS DE NOVAS TERAPÊUTICAS." In I Congresso Nacional de Pesquisas e Estudos Genéticos On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/geneticon/9157.

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Introdução: A psoríase é uma doença inflamatória e crônica de pele, não contagiosa. Sua etiologia exata ainda é desconhecida, porém estudos contemporâneos associam a doença a fortes predisposições genéticas associadas a elevada carga psicologia que podem levar a doença referida. Os recentes avanços na compreensão dos mecanismos fisiopatológicos da doença permitiram o progresso de novas terapêuticas, em especial pelo desenvolvimento de anticorpos monoclonais, graças a multiplicidade dos alvos terapêuticos, como as interleucinas 17, interleucina 12 e interleucina 23, que são alvos dos mediadores implicados na cascata inflamatória envolvida na psoríase mesmo não sendo agentes biológicos, mas sim sintéticos. Objetivos: Buscar na literatura atualizações e evidencias de possíveis novas terapêuticas sobre o tratamento da psoríase por meio de anticorpos monoclonais. Métodos: Foi realizada uma revisão bibliográfica por meio das plataformas de pesquisa Google Acadêmico e Lilacs, o recorte temporal foi de 2015 a 2022, foram utilizados como descritores em saúde: anticorpos monoclonais, psoríase e terapêutica. Foram pesquisados artigos nacionais e internacionais publicados em português e inglês, foram excluídas cartas ao editor, trabalhos de conclusão de curso e outras revisões. Resultados: Foram selecionados 12 artigos. Foi evidenciado o uso de três anticorpos monoclonais sendo eles: Ustequinumabe, que revelou causar hemofilia adquirida nos pacientes com a doença, sendo uma das propostas de recurso mais seguros, a mudança de posologia de três em três meses e diminui a frequência de administração por via subcutânea, já o Ixekizumabe foi considerado o imunobiológico mais eficiente no tratamento a curto prazo para psoríase , todavia não há garantia de sua segurança em um longo período de tempo, em última análise a Secukinumabe é o imunobiológico que obteve mais respostas a longo prazo que age como anti interleucina 17 obtendo uma eficácia superior do que agindo nas outras interleucinas, entretanto seu uso deprecia o sistema de defesa e propicia a disseminação de fungos. Conclusão: O uso de anticorpos monoclonais está sendo cada vez mais utilizado para o tratamento e mediação da psoríase, constatando-se que Ustequinumabe, Ixekizumabe, Secukinumabe são os de primeira escolha, porém ainda necessitam de estudos para elucidar melhor seus efeitos a longo prazo.
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Farias, Stephanie Freire Soares de, Graziela Gama da Conceição Gomes, Biatriz Costa Diniz, CAIO DE BRITO MATOS, and MARCOS VINÍCIUS SOUZA DE ALMEIDA. "GENES RELACIONADOS AO CÂNCER DE MAMA: UM ESTUDO ACERCA DOS ONCOGENES." In I Congresso Nacional de Pesquisas e Estudos Genéticos On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/geneticon/9136.

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Introdução: O câncer de mama é uma patologia relacionada a mutações genéticas, como alterações patológicas em genes como: BRCA 1 e BRCA 2. De acordo com dados do Instituto Nacional do Câncer, no ano de 2022, é estimado 68.280 novos casos, número que representa uma incidência de 43,74 casos por 100 mil individuos do sexo feminino. Objetivo: entender a relação dos genes com o desenvolvimento do câncer de mama. Materiais e Métodos: foi realizado um levantamento bibliográfico nos bancos de dados online NCBI, Scielo e Lilacs, durante o mês de junho de 2022, utilizando as palavras-chaves, isoladas e combinadas na língua portuguesa: câncer de mama, oncogenes e genes. Os artigos selecionados atendem ao período de 2017 a 2022, abordando a relação de genes com o câncer de mama. Resultados e Discussões: Foram identificados 32 artigos, dos quais 5 foram selecionados. Observou-se que a incidência do câncer de mama em portadores da mutação nos genes BRCA 1 e BRCA 2 são maiores que em vítimas do câncer de mama esporádico. Além disso, apesar de raro, a hereditariedade se configura como fator de risco para o desenvolvimento desse tipo de câncer, pois mutações nos genes BRCA 1 e BRCA 2 podem estar presentes nas células germinativas. Tais genes são designados genes supressores tumorais e se encontram associados à atividade celular, por exemplo o reparo de danos ao DNA, o ajuste da expressão gênica e o comando do ciclo celular. Assim, esses genes têm correspondência e ação essencial no câncer de mama genético, já que mutações nesses genes exprimem 85% dos sucedidos de câncer de mama. Ademais, visto que os genes BRCA1 e BRCA2 estão descritos como genes supressores de tumor, são encarregados pela regulação a proliferação celular de forma negativa e atuam na apoptose, ou seja, uma imperfeição ou outra variação em algum desses genes contribui para o acréscimo da predisposição ao câncer de mama. Conclusão: o câncer de mama é acometido em pacientes com mutações nos genes BRCA 1 e BRCA 2, sendo fundamental aprofundar pesquisas para melhor entender a atuação desses genes na fisiopatologia do câncer de mama.
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Niu, Yan-xiu, Fu-kuan Zhao, Jian-jing Zhang, Jing Xia, and Ying-ying Fan. "Notice of Retraction: Clustering Analysis and Identification of Genetic Diversities in Lilium Varieties with IRAP." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5780113.

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Silva, Gustavo Figueiredo da, Bruno Mattei Lopes, Vinicius Moser, and Leslie Ecker Ferreira. "Impact of pharmacogenetics on aspirin resistance: a systematic review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.663.

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Background: Pharmacogenetics promises better control of diseases, such as Cardiovascular disease (CVD). Acetylsalicylic acid, aspirin, prevents the formation of an activating agent of platelet aggregation and vasoconstriction, and it is used to prevent CVD. Nevertheless, patients may have treatment failure, causing recurrence and increased mortality, due to medication adherence, drug- drug interactions, aspirin-independent thromboxane A2 synthesis or genetic variants. In this sense, genetic variants have been related with aspirin resistance (AR). Objective: To evaluate the evidence of impact of genetic variants on AR through systematic literature review. Design and setting: Systematic review. Methods: Articles published since 2009 in MEDLINE/PubMed, Cochrane, Scopus, LILACS and SCIELO were systematically screened. Results: The genetic variants rs1126643 (ITGA2), rs3842787 (PTGS1), rs20417 (PTGS2) and rs5918 (ITGB3) were the most studied. As for the relevance of the genetic variants studied, of the 64 evaluated, 14 had statistical significance (p <0.05, 95% CI) in at least one article. Among them, the following have had unanimous. Results: rs1371097 (P2RY1), rs1045642 (MDR1), rs1051931 and rs7756935 (PLA2G7), rs2071746 (HO1), rs1131882 and rs4523 (TBXA2R), rs434473 (ALOX12), rs9315042 (ALOX5AP) and rs662 (PON1). While these differ in real interference in AR: rs5918 (ITGB3), rs2243093 (GP1BA), rs1330344 (PTGS1) and rs20417 (PTGS2). Conclusion: As limitations of our study, we highlight the non-uniform methodologies of the analyzed articles, as well as population differences. It is also noteworthy that pharmacogenetics is an expanding area. Therefore, further studies are needed to better understand the association between genetic variants and AR, as well as the practical application.
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Souza, Felipe dos Santos, Matheus Furlan Chaves, and Guilherme da Cunha Messias dos Santos. "Rhodopsin stimulation in neural circuits by neuromodulation in optogenetics: current findings on the use of Deep Brain Stimulation (DBS)." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.302.

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Introduction: Optogenetic neuromodulation describes a contemporary technique of brain modulation that has been increasingly studied, both in the field of genetic engineering and in neuroscience, for the treatment of diseases such as epilepsy, schizophrenia, parkinson and essential tremor. Through it, we seek to alter neurons, making them sensitive to light stimulation. For this, viral vectors are used to insert opsin genes into neural tissue. Objective: to describe the most recent scientific findings related to the use of DBS using Optogenetics techniques. Methodology: use of databases, SCIELO, PUBMED, LILACS and American Association of Neurological Surgeons using the following descriptors: Genetic Engineering. Deep Brain Stimulation. Optogenetics. Rhodopsins. Results: The use and Deep Brain Stimulantion (DBS) or Pronfunda Cerebral Stimulation (ECP) for therapeutic intervention in patients with movement disorders is performed through the insertion of a tungsten wire in specific areas of the central nervous system with the passage of electric current from microampers for milliseconds. However, over time, this causes plasticity, associated with gliosis and loss of DBS effectiveness. In addition, scientific evidence shows that cerebral neuromodulation by optogenetics in patients with dystonia, depression and obsessive compulsive disorder (OCD) is also already a reality with significant and approved results. Conclusions: Optognetics can replace classic DBS for the treatment of several neurological comorbidities with safety and space-time precision, with minimal side effects, when compared with that technique.
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Rodrigues, Antonio Rony da S. P., and Edinalda Maria Cavalcante. "ESTUDO GENÉTICO DO CÂNCER DE TIREOIDE – UMA REVISÃO." In I SIMPÓSIO MARANHENSE DE GENÉTICA E GENÔMICA EM SAÚDE. Doity - Plataforma de Eventos, 2022. http://dx.doi.org/10.55664/simaggens2022.005.

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INTRODUÇÃO: O câncer de tireoide é um dos agravos mais comuns ao sistema endócrino, com o maior aumento anual de incidência em diferentes países, principalmente devido à melhoria das tecnologias de diagnóstico, sendo mais proeminente em regiões com acesso aos cuidados de saúde amplamente disponíveis. Alguns eventos moleculares são descritos tanto na carciogênese da tireoide quanto na evolução do tumor glandular. Dados do Atlas do câncer no Genoma Humano dividiu os carcinomas papilíferos de tireoide nas categorias BRAF e RAS, com base nos resultados do exoma do sequenciamento de DNA, RNA e perfil proteômico, e padrões de metilação. OBJETIVOS: Observar nos estudos da literatura os marcadores genéticos relacionados ao câncer de tireóide. MÉTODOS MÉTODOS: Para alcançar os objetivos propostos neste estudo, o método eleito foi a Revisão Integrativa que inclui a análise de pesquisas relevantes que dão suporte para a tomada de decisão, permitindo a incorporação desses achados na prática clínica. A partir de então, foi feita uma busca, ocorrida entre fevereiro e março de 2022, em 5 bases de dados: LILACS (Literatura Latino-Americana e do Caribe em Ciências da Saúde) e SciELO (Scientific Electronic Library Online), PubMed (Central: PMC- National Library of Medicine National Institutes of Health), ScienceDirect e IBECS (Índice Bibliográfico Espanhol em Ciências da Saúde). A pesquisa por artigos foi feita através dos termos em língua inglesa: “thyroid cancer”, “risk markers” e “thyroid cancer genetics” junto ao operador booleano AND. Os resultados obtidos foram comparados, estabelecendo-se concordância quanto a formulação da amostra final. Os achados foram apresentados a partir do método de “nuvem de palavras”, utilizando o software wordle. Nuvem de palavras é uma forma de facilitar a demonstração de quais são as palavras mais frequentes quando pesquisado por determinado assunto ou tema. RESULTADOS E DISCUSSÃO: Na etapa de seleção subsequente os artigos foram lidos na íntegra onde 213 artigos foram excluídos por não se apresentarem dentro do objeto estudo, e incluídos 14 trabalhos na versão final da revisão. A análise proteica demostrou projeção da estrutura molecular e homologia proteica dos seguintes marcadores moleculares de câncer de tireoide: proto-oncogene receptor tirosina quinase (RET); proto-oncogene do receptor de tirosina quinase neurotrófico 1 (NTRK1); homólogo de fosfatase tensina (PTEN); gene da proteína tumoral p53 (TP53); fosfoinositida 3-quinase/treonina proteína quinase (PI3K/AKT); catenina beta 1 (CTNNB1); gama de receptor ativado por proliferador de peroxissoma de caixa pareada 8 (PAX8-PPARG); oncogene viral de sarcoma de rato (RAS); proto-oncogene B-raf, serina/treonina quinase (BRAF); e receptor do hormônio estimulante da tireóide (TSHR). Experimentos utilizando o tipo de array identificaram três genes diferencialmente expressos, cuja expressão foi analisada por RT-PCR em 10 amostras de cada tipo de tecido. Dois deles foram capazes de diferenciar carcinomas papilíferos de tecido normal e bócio com 89% de precisão para o tumor maligno e 80% para os tecidos não malignos. Conclusão: Após a análise dos resultados desta RI, foi possível observar alguns marcadores de risco para câncer de tireóide. Desse modo, o presente trabalho contribui para o aprofundamento e desenvolvimento de novas reflexões dos estudos sobre marcadores genéticos canceriginos
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Reports on the topic "Lilies Genetics"

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Gera, Abed, Abed Watad, P. Ueng, Hei-Ti Hsu, Kathryn Kamo, Peter Ueng, and A. Lipsky. Genetic Transformation of Flowering Bulb Crops for Virus Resistance. United States Department of Agriculture, January 2001. http://dx.doi.org/10.32747/2001.7575293.bard.

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Objectives. The major aim of the proposed research was to establish an efficient and reproducible genetic transformation system for Easter lily and gladiolus using either biolistics or Agrobacterium. Transgenic plants containing pathogen-derived genes for virus resistance were to be developed and then tested for virus resistance. The proposal was originally aimed at studying cucumber mosaic virus (CMV) resistance in plants, but studies later included bean yellow mosaic virus (BYMV). Monoclonal antibodies were to be tested to determine their effectiveness in interning with virus infection and vector (aphid) transmission. Those antibodies that effectively interfered with virus infection and transmission were to be cloned as single chain fragments and used for developing transgenic plants with the potential to resist virus infection. Background to the topic. Many flower crops, as lily and gladiolus are propagated vegetatively through bulbs and corms, resulting in virus transmission to the next planting generation. Molecular genetics offers the opportunity of conferring transgene-mediated disease resistance to flower crops that cannot be achieved through classical breeding. CMV infects numerous plant species worldwide including both lilies and gladioli. Major conclusions, solutions and achievements. Results from these for future development of collaborative studies have demonstrated the potential transgenic floral bulb crops for virus resistance. In Israel, an efficient and reproducible genetic transformation system for Easter lily using biolistics was developed. Transient as well as solid expression of GUS reporter gene was demonstrated. Putative transgenic lily plantlets containing the disabled CMV replicase transgene have been developed. The in vitro ability of monoclonal antibodies (mAbs) against CMV to neutralize virus infectivity and block virus transmission by M. persicae were demonstrated. In the US, transgenic Gladiolus plants containing either the BYMV coat protein or antisense coat protein genes have been developed and some lines were found to be virus resistant. Long-term expression of the GUS reporter gene demonstrated that transgene silencing did not occur after three seasons of dormancy in the 28 transgenic Gladiolus plants tested. Selected monoclonal antibody lines have been isolated, cloned as single chain fragments and are being used in developing transgenic plants with CMV resistance. Ornamental crops are multi-million dollar industries in both Israel and the US. The increasing economic value of these floral crops and the increasing ban numerous pesticides makes it more important than ever that alternatives to chemical control of pathogens be studied to determine their possible role in the future. The cooperation resulted in the objectives being promoted at national and international meetings. The cooperation also enabled the technology transfer between the two labs, as well as access to instrumentation and specialization particular to the two labs.
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