Relevant bibliographies by topics / Ligand-trap

Academic literature on the topic 'Ligand-trap'

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Published: 9 March 2023
Last updated: 10 March 2023

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Journal articles on the topic "Ligand-trap"

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Kreutzkamp, Barbara. "„ligand trap“ als neue Therapieoption." InFo Onkologie 21, no. 4 (May 2018): 42. http://dx.doi.org/10.1007/s15004-018-6108-2.

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RAMESH, Vasudevan, and Tom BROWN. "1H-NMR characterization of l-tryptophan binding to TRAP, the trp RNA-binding attenuation protein of Bacillus subtilis." Biochemical Journal 315, no. 3 (May 1, 1996): 895–900. http://dx.doi.org/10.1042/bj3150895.

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A 1H-NMR study of the binding of L-tryptophan to the trp RNA-binding attenuation protein of Bacillus subtilis (TRAP), an ondecamer (91.6 kDa), has been implemented. The assignment of the aromatic indole ring proton resonances of the bound tryptophan ligand has been successfully carried out by two-dimensional chemical exchange experiments. The observation of only a single set of chemical shifts of the bound ligand demonstrates that the tryptophan binding site is identical in all the 11 subunits of the protein. Further, the large change in ligand chemical shifts suggests that the conformation of tryptophan ligand undergoes a significant rearrangement after complex formation with TRAP. This is further substantiated by the extensive ligand-induced chemical shift changes observed to the protein resonances and identification of several strong ligand–protein intermolecular nuclear Overhauser effects. A correlation of these preliminary NMR data with the X-ray crystal structure of the TRAP–tryptophan complex also suggests, tentatively, that the observed changes to the NMR spectra of the protein might correspond to changes associated with residues surrounding the tryptophan binding pocket owing to complex formation.
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Jahn, Olaf, Jelena Radulovic, Oliver Stiedl, Hossein Tezval, Klaus Eckart, and Joachim Spiess. "Corticotropin-Releasing Factor Binding Protein - A Ligand Trap?" Mini-Reviews in Medicinal Chemistry 5, no. 10 (October 1, 2005): 953–60. http://dx.doi.org/10.2174/138955705774329500.

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Malay, Ali D., Masahiro Watanabe, Jonathan G. Heddle, and Jeremy R. H. Tame. "Crystal structure of unliganded TRAP: implications for dynamic allostery." Biochemical Journal 434, no. 3 (February 24, 2011): 427–34. http://dx.doi.org/10.1042/bj20101813.

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Allostery is vital to the function of many proteins. In some cases, rather than a direct steric effect, mutual modulation of ligand binding at spatially separated sites may be achieved through a change in protein dynamics. Thus changes in vibrational modes of the protein, rather than conformational changes, allow different ligand sites to communicate. Evidence for such an effect has been found in TRAP (trp RNA-binding attenuation protein), a regulatory protein found in species of Bacillus. TRAP is part of a feedback system to modulate expression of the trp operon, which carries genes involved in tryptophan synthesis. Negative feedback is thought to depend on binding of tryptophan-bound, but not unbound, TRAP to a specific mRNA leader sequence. We find that, contrary to expectations, at low temperatures TRAP is able to bind RNA in the absence of tryptophan, and that this effect is particularly strong in the case of Bacillus stearothermophilus TRAP. We have solved the crystal structure of this protein with no tryptophan bound, and find that much of the structure shows little deviation from the tryptophan-bound form. These data support the idea that tryptophan may exert its effect on RNA binding by TRAP through dynamic and not structural changes, and that tryptophan binding may be mimicked by low temperature.
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Miao, Le-Ping, Qi Qi, Xiang-Bin Han, and Wen Zhang. "DCM self-trapping by the host deformation in flexible host–guest molecules." CrystEngComm 23, no. 23 (2021): 4136–42. http://dx.doi.org/10.1039/d1ce00301a.

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The desolvated structure can self-trap the DCM molecules to return to the 1·DCM state via ligand deformation even under weak host–guest interactions. The capture behavior of DCM is mostly due to the flexibility of the ligand.
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Tavakoli Dastjerdi, Hadi, Daniel Prochowicz, Pankaj Yadav, and Mohammad Mahdi Tavakoli. "Synergistic ligand exchange and UV curing of PbS quantum dots for effective surface passivation." Nanoscale 11, no. 47 (2019): 22832–40. http://dx.doi.org/10.1039/c9nr07854a.

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Gervasi, Christian F., Dmitry A. Kislitsyn, Thomas L. Allen, Jason D. Hackley, Ryuichiro Maruyama, and George V. Nazin. "Diversity of sub-bandgap states in lead-sulfide nanocrystals: real-space spectroscopy and mapping at the atomic-scale." Nanoscale 7, no. 46 (2015): 19732–42. http://dx.doi.org/10.1039/c5nr05236j.

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Dundas, Kirsten, Melanie J. Shears, Yi Sun, Christine S. Hopp, Cecile Crosnier, Tom Metcalf, Gareth Girling, Photini Sinnis, Oliver Billker, and Gavin J. Wright. "Alpha-v–containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP." Proceedings of the National Academy of Sciences 115, no. 17 (April 9, 2018): 4477–82. http://dx.doi.org/10.1073/pnas.1719660115.

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Malaria-causing Plasmodium sporozoites are deposited in the dermis by the bite of an infected mosquito and move by gliding motility to the liver where they invade and develop within host hepatocytes. Although extracellular interactions between Plasmodium sporozoite ligands and host receptors provide important guidance cues for productive infection and are good vaccine targets, these interactions remain largely uncharacterized. Thrombospondin-related anonymous protein (TRAP) is a parasite cell surface ligand that is essential for both gliding motility and invasion because it couples the extracellular binding of host receptors to the parasite cytoplasmic actinomyosin motor; however, the molecular nature of the host TRAP receptors is poorly defined. Here, we use a systematic extracellular protein interaction screening approach to identify the integrin αvβ3 as a directly interacting host receptor for Plasmodium falciparum TRAP. Biochemical characterization of the interaction suggests a two-site binding model, requiring contributions from both the von Willebrand factor A domain and the RGD motif of TRAP for integrin binding. We show that TRAP binding to cells is promoted in the presence of integrin-activating proadhesive Mn2+ ions, and that cells genetically targeted so that they lack cell surface expression of the integrin αv-subunit are no longer able to bind TRAP. P. falciparum sporozoites moved with greater speed in the dermis of Itgb3-deficient mice, suggesting that the interaction has a role in sporozoite migration. The identification of the integrin αvβ3 as the host receptor for TRAP provides an important demonstration of a sporozoite surface ligand that directly interacts with host receptors.
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Bartual-Murgui, C., S. Vela, O. Roubeau, and G. Aromí. "Designed intramolecular blocking of the spin crossover of an Fe(ii) complex." Dalton Transactions 45, no. 36 (2016): 14058–62. http://dx.doi.org/10.1039/c6dt03047e.

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Ghosh, Ashta Chandra, Jakob Klaus Reinhardt, Markus Karl Kindermann, and Carola Schulzke. "The ring opening reaction of 1,3-dithiol-2-one systems is fully reversible." Chem. Commun. 50, no. 70 (2014): 10102–4. http://dx.doi.org/10.1039/c4cc04414b.

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The deprotection of a common precursor moiety in dithiolene chemistry was discovered to be fully reversible, which, besides being relevant for researchers working in very different fields with these non-innocent ligand systems, may even have an impact on CO2 housekeeping, as the deprotected ligand acts as an efficient trap.
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Dissertations / Theses on the topic "Ligand-trap"

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Milne, Charlotte Anne. "Analysis of neural development using ligand-trap transgenic lines." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444843/.

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Bone Morphogenetic Proteins (BMPs) are members of the Transforming Growth Factor-beta (TGF-beta) signalling protein superfamily. BMPs play important and diverse roles in cell-cell signalling, including establishing cell fate during the development of vertebrate embryos. Their activity is antagonised in vivo by a number of proteins such as noggin, which sequester BMP ligands, preventing them from binding to BMP receptors. This thesis describes studies to establish a binary genetic approach combined with a ligand trap system to manipulate BMP signalling in the frog embryo. This system has been used to investigate the roles of BMP signalling in dorso-ventral patterning of the forebrain Xenopus tropicalis. The binary system described utilises a variety of tissue- or region-specific gene promoters to drive expression of the GAL4 transcriptional activator. Such transgenic "driver" lines can be crossed with a "responder" line in which expression of a membrane-tethered fusion protein comprising human Noggin fused to GFP is regulated by a synthetic promoter responsive to GAL4 (UAS-flognog). Transient expression assays confirmed the effectiveness of the "responder" line, GAL4 transactivation of UAS-flognog resulted in the expression of Flognog and an expansion of neural progenitor tissue, indicated by the X-Sox3 marker. In a binary cross with the Otx2-gal4 driver line, targeted GAL4 transactivation lead to a decrease in phospho-Smad-1 staining in the anterior CNS and eye in a proportion of cross embryos. Such a cross resulted in embryos showing an open neural tube and alterations in both Pax6 (dorsal) and X-
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Nuamchit, Teonchit. "Directed evolution and characterisaton of an Ang2-selective ligand trap." Thesis, University of Leicester, 2014. http://hdl.handle.net/2381/38796.

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The angiopoietin (Ang) ligands and their Tie2 receptor play a role in vascular growth, maintenance of adult vasculature and vascular remodelling. Many studies showed that Ang1 ligand has a protective effect for controlling of vascular morphogenesis and homeostasis whereas excess Ang2 has more deleterious effect on the vascular system. Upregulated expression of Ang2 is associated with several pathologies such as inflammation and tumour angiogenesis, and blocking Ang2 with antibodies or using transgenic approaches has been shown to be improve outcomes in preclinical models of these conditions. Ang2 inhibitors therefore have significant potential as therapeutics. Ligand traps are alternatives to antibodies for blocking the action of ligands. This study aims to use directed evolution to modify Tie2 extracellular domain to a form that selectively binds Ang2 binding, and test its ability to supress Ang2-mediated effects. Such a selective ectodomain would be a candidate Ang2 ligand trap. Directed evolution was attempted using a method that combines in-cell mutagenesis, utilizing somatic hypermutation, with cell surface display. Despite several attempts evolution was not successful. However, an evolved ectodomain was produced by others. This evolved ectodomain was analysed for binding specificity, cellular, in vivo effects. The ectodomain was found to be selective for Ang2 binding, and unable to bind Ang1 and Ang4. Furthermore, the evolved ectodomain was found to inhibit the antagonistic and agonistic effects of Ang2 on endothelial cell Akt signalling. Studies were also found that the evolved ectodomain was able to inhibit endothelial cell migration in response to high concentrations of Ang2. Preliminary in vivo work showed that the ectodomain was able to block localized oedema in a mouse model of lipopolysaccharide-induced inflammation. These findings suggest the evolved ectodomain would be a good candidate for development into an Ang2-ligand-trap.
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Kleckner, Ian Robert. "Thermodynamic, Kinetic, and Dynamics Studies of the Allosteric Ligand-Responsive Regulatory Protein TRAP." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313460041.

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Pettersson, Sara. "Development of siRNA against the CYP1A1 gene for trap of endogenous Ah-receptor ligand." Thesis, Södertörn University College, School of Life Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-878.

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The aryl hydrocarbon receptor (Ah-receptor) is a member of the bHLH-PAS protein family. The Ah-receptor is a ligand dependent transcription factor, which activates a wide range of genes, most notably the xenobiotica metabolising genes, CYP1A1 and CYP1A2. The biological function of the Ah-receptor is still unknown and an endogenous ligand has yet not been identified. A possible Ah-receptor ligand is 6-formylindolo[3,2-b]carbazole (FICZ). FICZ has a high affinity for the Ah-receptor and is rapidly metabolised by CYP1A1, CYP1A2 and aldehydeoxidase (AOX). To try to trap FICZ or other possible endogenous Ah-receptor ligands, the metabolising enzymes CYP1A1, CYP1A2 and AOX were blocked. This was achieved through chemical blockage of CYP1A1 and CYP1A2 by ellepticin and through silencing with siRNA directed against CYP1A1 and CYP1A2. Successful blockage would be seen as an increase in Ah-receptor dependent XRE-luciferase activity. Chemical blockage of AOX with tungstate did not affect FICZ-dependent XRE-luciferase activation which could indicate that HepG2 cells lack AOX. The chemical blockage of CYP1A1 and CYP1A2 with ellepticin modified the XRE-luciferase response, but did not completely block Ah-receptor activation. In addition it is possible that ellepticin is a ligand for the Ah-receptor. The blockage of CYP1A1 by siRNA was successful; a silencing of CYP1A1 mRNA by at least 50 percent was detected. However due to lack of time it was not tested if the blockage of CYP1A1 and CYP1A2 was sufficient to trap Ah-receptor ligands.

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Chien, Wen-Fang Winnie. "Investigation of uranium and various ligand complexes in the gas phase using electrospray ionization ion trap mass spectrometry." Thesis, Wichita State University, 2007. http://hdl.handle.net/10057/1518.

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The speciation and reactivity of uranium is a topic of sustained interest because species dependent chemistry controls processes ranging from nuclear fuel processing to mobility and fate in the geological surface. Past condensed phase studies have shown uranium a wide range of oxidation states and coordinate ion numbers in the environment. These studies have also suggested the strong interactions such as charge transfer between the uranium cations and solvent molecules cause the latter to behave like equatorial ligands. Studying and understanding intrinsic uranium chemistry is challenging because it is difficult to gain explicit control over the interactions of solvent and non-solvent ligands with uranyl ions in the condensed phase. An attractive alternative, therefore, is to monitor reaction in the gas phase (i.e. a solution free environment) in order to gain control over the chemical species chosen for study and the specific neutral reagents. Recent studies shown that ion-trap mass spectrometry can be applied to the study of intrinsic metal and metal-complex chemistry by generating the metal complexes as ions through electrospray ionization ESI and allowing species to interact with neutral reagents present in the collision gas. Throughout these series of uranyl studies, ESI is used to produce gas-phase ions from solutions containing uranyl nitrate complexes in deionized water. Several studies were conducted to monitor uranium and ligands behavior under different systems by controlling factors such as the numbers of ligands attached to the uranium dioxo cation center, ligand degrees of freedom, and ligand basicities. These studies were designed to gain clear insight to the intrinsic behavior of uranium complexes.
Thesis (M.S.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistry
"December 2007."
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Chien, Wen-Fang Winnie Van Stipdonk Michael J. "Investigation of uranium and various ligand complexes in the gas phase using electrospray ionization ion trap mass spectrometry /." Thesis, A link to full text of this thesis in SOAR, 2007. http://hdl.handle.net/10057/1518.

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Graf, Daniel. "Cloning and characterziation of TRAP (CD40 Ligand) and its role in the primary immunodeficiency 'X-linked immunodeficiency with hyper-IgM' /." [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10753.

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DE, ROSA GIANLUCA. "UNRAVELING THE MOLECULAR PATHOGENESIS OF INEFFECTIVE ERYTHROPOIESIS IN CONGENITAL DYSERYTHROPOIETIC ANEMIA TYPE II: IN VITRO EVALUATION OF RAP-011 TREATMENT." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/697529.

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Congenital Dyserythropoietic Anemias (CDAs) are subtypes of bone marrow failure syndromes, hallmarked by ineffective erythropoiesis. The most common form is CDA type II (CDAII), showing moderate/severe anemia, relative reticulocytopenia, jaundice, splenomegaly, and iron overload. It is inherited as an autosomal recessive disorder due to loss-of-function mutations in the SEC23B gene. Molecular pathogenesis of CDA II still has to be investigated because the described animal models did not recapitulate the clinical features observed in humans. To date, treatments for CDAII patients consist of supportive therapy, such as erythrocyte transfusions, or bone marrow transplantation or splenectomy in transfusion-dependent cases. Recently, members of TGF-β superfamily have been studied as potential regulators of erythropoiesis, especially the growth differentiation factor 11 (GDF11). Through the binding of specific receptors, GDF11 leads to an inhibited late-stage erythropoiesis. Indeed, two GDF11 inhibitors, ACE-011 and ACE-536, have been associated with an improvement of hematologic parameters. Studies with the mouse counterpart of ACE-011, RAP-011, on a mouse model of β-thalassemia showed increased differentiation of erythroid cells, improvement of the anemic condition and reduced iron overload in treated mice. The first aim of our study was the establishment of a cellular model of CDA II, that could reproduce the main defects of the disease, such as the lack of the erythroid differentiation due to the low or absent expression of SEC23B gene. For this aim, we selected the K562 cell line and, through short-hairpin RNA-based strategy, we obtained two different clones of K562 showing a stable silencing of SEC23B. Then, we decided to assess the effects of RAP-011 on this CDA II model, by investigating the pathway involved in the GDF11 signaling. This treatment simulated the ligand trap function played by RAP-011 towards GDF11. The administration of RAP-011 resulted in a reduction of SMAD2 phosphorylation induced by GDF11 and, moreover, in an increase of different erythroid differentiation markers.
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Conference papers on the topic "Ligand-trap"

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Brewer, Bryson M., Yandong Gao, Rebecca M. Sappington, and Deyu Li. "Microfluidic Molecular Trap: Probing Extracellular Signaling by Selectively Blocking Exchange of Specific Molecules in Cell-Cell Interactions." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-64489.

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Communication among cell populations is achieved via a wide variety of soluble, extracellular signaling molecules [1]. In order to investigate the role of specific molecules in a cellular process, researchers often utilize in vitro cell culture techniques in which the molecule under question has been removed from the signaling pathway. Traditionally, this has been accomplished by eliminating the gene in the cell that is responsible for coding the targeted ligand/receptor by using modern DNA technology such as gene knockout; however, this process is expensive, time-consuming, and labor intensive. Previously, we have demonstrated a microfluidic platform that uses a semi-permeable barrier with embedded receptor-coated nanoparticles to selectively remove a specific molecule or ligand from the extracellular signaling pathway in a cell co-culture environment [2]. This initial proof-of-principle was conducted using biotinylated nanoparticles and fluorescently tagged avidin molecules, as the avidin/biotin complex is the strongest known non-covalent interaction between a protein and a ligand (Dissociation constant kd = 10−15 M). Also, the trap was only effective for short time periods (<15 min) because the high concentration of fluorescently tagged avidin molecules required for visualization quickly saturated the barrier. However, nearly all biologically relevant ligand-receptor interactions have lower binding affinities than the avidin-biotin complex, with dissociation constants that are larger by several orders of magnitude. In addition, many in vitro cell culture experiments are conducted over multiple hours or days. Thus, a practically useful molecular trap device must be able to operate in a lower binding affinity regime while also lasting for extended time periods. Here we present results in which a biotinylated-particle barrier was used to successfully block lower concentrations of fluorescently tagged avidin for multiple days, showcasing the applicability of the device for long term experiments. In addition, we introduce a modified molecular trap in which the protein A/goat IgG complex was used to demonstrate the effectiveness of the platform for lower binding affinity protein-ligand interactions. These results indicate the potential usefulness of the microfluidic molecular trap platform for probing extracellular signaling pathways.
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Israil, R., L. Schüssler, M. Schmitt, M. Grupe, P. Hütchen, W. R. Thiel, R. Diller, and C. Riehn. "Ultrafast Dynamics of RuII-polypyridyl Complexes – Photoinduced Ligand Dissociation Dynamics in Gas Phase and Solution." In International Conference on Ultrafast Phenomena. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/up.2022.tu4a.4.

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Ultrafast electronic dynamics and UV absorption of [RuII(bipyridine)2(nicotinamide)2]2+ isolated in an ion trap reveal by transient photodissociation short time constants and spectra comparable to transient absorption in solution. Ligand dissociation dynamics are elucidated.
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Gao, Yandong, Dana Brantley-Sieders, Devi Majumdar, Jin Chen, Donna Webb, and Deyu Li. "A Simple Approach to Probe the Extracellular Signaling Pathways Using Ligand Traps." In ASME 2012 Third International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/mnhmt2012-75106.

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Cells communicate with one another through a huge variety of extracellular soluble signaling molecules. A common method in biology to investigate the signaling pathways is to inactivate the gene coding the interested ligand or receptor from cells using modern DNA technology, known as gene knockout. Even though very effective, however, gene knockout is a time-consuming and cost-prohibitive process and requires huge amount of efforts to conduct. Here we present a simple method to probe the extracellular signaling pathways through engineering a semi-permeable barrier between two cell populations. In this approach, ligand traps, receptor-coated nano/micro-particles, are embedded inside the nanoporous barrier. Because the receptors have the ability to selectively bind to certain ligand(s) with high affinity, the associated ligands can be ‘trapped’ inside the barrier when they try to perfuse from one cell population to the other. As a result, the targeted soluble ligands can be effectively blocked from the molecular exchange between the two cell populations. We have demonstrated the feasibility of this novel approach using fluorescent proteins. An analytical model has also been developed to guide the design of the ligand-trap-embedded barrier.
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Schang, G., M. Poujol De Molliens, J. Denis, C. Chauvet, E. Brûlé, V. Ganesh, J. Schoelermann, G. Tremblay, I. Tikhomirov, and M. O'Connor-Mccourt. "HS135: Novel Activin & GDF Ligand Trap for the Treatment of Pulmonary Hypertension (PH)." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.3238.

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Zhang, Xingao, Margaret Hudson, and Felix Castellano. "Selective Passivation of Electron Trap States in InP Quantum Dots with X-type Ligand Benzoic Acids." In nanoGe Fall Meeting 2021. València: Fundació Scito, 2021. http://dx.doi.org/10.29363/nanoge.nfm.2021.020.

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Wang, Jiin-Tarng, Chi-Ling Tseng, Han-Feng Teng, Pan-Hsien Kuo, Yun-Chih Cheng, Yi-Jing Chen, Yi-Hsuan Lu, et al. "496 HCB101: A safe and effective ligand trap therapeutic targeting the CD47-SIRPa signaling pathway for cancer treatment." In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0496.

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Harding, Thomas, Servando Palencia, Tiffany Wallace, Anita Levin, Namrata Patil, Ruby Cheung, Mallory Aguirre, et al. "Abstract 1876: Preclinical efficacy of fibroblast growth factor ligand trap HGS1036 in lung carcinoma models with genomic amplification ofFGFR1." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-1876.

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Bellovin, David I., Servando Palencia, Kevin Hestir, Ernestine Lee, M. Phillip DeYoung, Thomas Brennan, Gerrit Los, and Kevin Baker. "Abstract 5449: FP-1039/GSK3052230, an FGF ligand trap, enhances VEGF antagonist therapy in preclinical models of RCC and HCC." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-5449.

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Young, M. Phillip De, Christian Sherk, Maureen Bleam, Mary Barnette, Gopi Ganji, Bao Hoang, James Tunstead, et al. "Abstract LB-236: Preclinical efficacy of targeting FGF autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-lb-236.

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Hawinkels, Lukas JAC, Amaya Garcia de Vinuesa, Madelon Paauwe, Marianna Kruithof-de Julio, Renier Heijkants, Marie-Jose Goumans, Timo ten Hagen, and Peter ten Dijke. "Abstract 1370: Activin receptor-like kinase 1 ligand trap reduces microvascular density and improves chemotherapy efficiency to various solid tumors." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1370.

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