Journal articles on the topic 'Ligand/substrate identification'
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Singh, Manvi, Priya Kempanna, and Kavitha Bharatham. "Identification of Mtb GlmU Uridyltransferase Domain Inhibitors by Ligand-Based and Structure-Based Drug Design Approaches." Molecules 27, no. 9 (April 28, 2022): 2805. http://dx.doi.org/10.3390/molecules27092805.
Rothweiler, Elisabeth M., Paul E. Brennan, and Kilian V. M. Huber. "Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators." Biological Chemistry 403, no. 4 (February 23, 2022): 391–402. http://dx.doi.org/10.1515/hsz-2021-0396.
Fernández, Rico-Jiménez, Ortega, Daddaoua, García García, Martín-Mora, Torres, Tajuelo, Matilla, and Krell. "Determination of Ligand Profiles for Pseudomonas aeruginosa Solute Binding Proteins." International Journal of Molecular Sciences 20, no. 20 (October 17, 2019): 5156. http://dx.doi.org/10.3390/ijms20205156.
Wang, Wenyuan, Junli Zhu, Qi Huang, Lei Zhu, Ding Wang, Weimin Li, and Wenjie Yu. "DFT Exploration of Metal Ion–Ligand Binding: Toward Rational Design of Chelating Agent in Semiconductor Manufacturing." Molecules 29, no. 2 (January 8, 2024): 308. http://dx.doi.org/10.3390/molecules29020308.
Weng, Z., S. M. Thomas, R. J. Rickles, J. A. Taylor, A. W. Brauer, C. Seidel-Dugan, W. M. Michael, G. Dreyfuss, and J. S. Brugge. "Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains." Molecular and Cellular Biology 14, no. 7 (July 1994): 4509–21. http://dx.doi.org/10.1128/mcb.14.7.4509-4521.1994.
Weng, Z., S. M. Thomas, R. J. Rickles, J. A. Taylor, A. W. Brauer, C. Seidel-Dugan, W. M. Michael, G. Dreyfuss, and J. S. Brugge. "Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains." Molecular and Cellular Biology 14, no. 7 (July 1994): 4509–21. http://dx.doi.org/10.1128/mcb.14.7.4509.
Evans, S. W., D. Rennick, and W. L. Farrar. "Identification of a signal-transduction pathway shared by haematopoietic growth factors with diverse biological specificity." Biochemical Journal 244, no. 3 (June 15, 1987): 683–91. http://dx.doi.org/10.1042/bj2440683.
Duarte Filho, Luiz Antonio Miranda de Souza, Cintia Emi Yanaguibashi Leal, Pierre-Edouard Bodet, Edilson Beserra de Alencar Filho, Jackson Roberto Guedes da Silva Almeida, Manon Porta Zapata, Oussama Achour, et al. "The Identification of Peptide Inhibitors of the Coronavirus 3CL Protease from a Fucus ceranoides L. Hydroalcoholic Extract Using a Ligand-Fishing Strategy." Marine Drugs 22, no. 6 (May 27, 2024): 244. http://dx.doi.org/10.3390/md22060244.
Drexler, Hannes C. A., Matthias Vockel, Christian Polaschegg, Maike Frye, Kevin Peters, and Dietmar Vestweber. "Vascular Endothelial Receptor Tyrosine Phosphatase: Identification of Novel Substrates Related to Junctions and a Ternary Complex with EPHB4 and TIE2." Molecular & Cellular Proteomics 18, no. 10 (August 19, 2019): 2058–77. http://dx.doi.org/10.1074/mcp.ra119.001716.
Lamaze, C., and S. L. Schmid. "Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase." Journal of Cell Biology 129, no. 1 (April 1, 1995): 47–54. http://dx.doi.org/10.1083/jcb.129.1.47.
Mora Lagares, Liadys, Yunierkis Pérez-Castillo, Nikola Minovski, and Marjana Novič. "Structure–Function Relationships in the Human P-Glycoprotein (ABCB1): Insights from Molecular Dynamics Simulations." International Journal of Molecular Sciences 23, no. 1 (December 29, 2021): 362. http://dx.doi.org/10.3390/ijms23010362.
Ruan, Ke-He. "High resolution nuclear magnetic resonance spectroscopy-guided mutagenesis for characterization of membrane-bound proteins: Experimental designs and applications." Spectroscopy 18, no. 1 (2004): 13–29. http://dx.doi.org/10.1155/2004/802728.
Reynolds, A. B., J. Daniel, P. D. McCrea, M. J. Wheelock, J. Wu, and Z. Zhang. "Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes." Molecular and Cellular Biology 14, no. 12 (December 1994): 8333–42. http://dx.doi.org/10.1128/mcb.14.12.8333-8342.1994.
Reynolds, A. B., J. Daniel, P. D. McCrea, M. J. Wheelock, J. Wu, and Z. Zhang. "Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes." Molecular and Cellular Biology 14, no. 12 (December 1994): 8333–42. http://dx.doi.org/10.1128/mcb.14.12.8333.
Adams, James, Benjamin P. Thornton, and Lydia Tabernero. "A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis." International Journal of Molecular Sciences 22, no. 22 (November 11, 2021): 12206. http://dx.doi.org/10.3390/ijms222212206.
Yadav, Rolly, Anwesh Pandey, Nidhi Awasthi, and Anamika Shukla. "Molecular Docking Studies of Enzyme Binding Drugs on Family of Cytochrome P450." Advanced Science, Engineering and Medicine 12, no. 1 (January 1, 2020): 83–87. http://dx.doi.org/10.1166/asem.2020.2520.
BARNETT, Stanley F., Deborah DEFEO-JONES, Sheng FU, Paula J. HANCOCK, Kathleen M. HASKELL, Raymond E. JONES, Jason A. KAHANA, et al. "Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors." Biochemical Journal 385, no. 2 (January 7, 2005): 399–408. http://dx.doi.org/10.1042/bj20041140.
Wei, Min, Richard Wynn, Gregory Hollis, Boshan Liao, Alexander Margulis, Brian G. Reid, Ronald Klabe, et al. "High-Throughput Determination of Mode of Inhibition in Lead Identification and Optimization." Journal of Biomolecular Screening 12, no. 2 (January 11, 2007): 220–28. http://dx.doi.org/10.1177/1087057106296679.
Takeuchi, Hajime, Daniel J. Rigden, Bahram Ebrahimi, Philip C. Turner, and Huw H. Rees. "Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration." Biochemical Journal 389, no. 3 (July 26, 2005): 637–45. http://dx.doi.org/10.1042/bj20050498.
D’Arrigo, Giulia, Ida Autiero, Eleonora Gianquinto, Lydia Siragusa, Massimo Baroni, Gabriele Cruciani, and Francesca Spyrakis. "Exploring Ligand Binding Domain Dynamics in the NRs Superfamily." International Journal of Molecular Sciences 23, no. 15 (August 5, 2022): 8732. http://dx.doi.org/10.3390/ijms23158732.
Basu, Nirmalya, Rashna Bhandari, Vivek T. Natarajan, and Sandhya S. Visweswariah. "Cross Talk between Receptor Guanylyl Cyclase C and c-src Tyrosine Kinase Regulates Colon Cancer Cell Cytostasis." Molecular and Cellular Biology 29, no. 19 (July 20, 2009): 5277–89. http://dx.doi.org/10.1128/mcb.00001-09.
Astegno, Alessandra, Alejandro Giorgetti, Alessandra Allegrini, Barbara Cellini, and Paola Dominici. "Characterization of C-S Lyase fromC. diphtheriae: A Possible Target for New Antimicrobial Drugs." BioMed Research International 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/701536.
Sanguinetti, Manuel, Lucianna Helene Silva Santos, Juliette Dourron, Catalina Alamón, Juan Idiarte, Sotiris Amillis, Sergio Pantano, and Ana Ramón. "Substrate Recognition Properties from an Intermediate Structural State of the UreA Transporter." International Journal of Molecular Sciences 23, no. 24 (December 16, 2022): 16039. http://dx.doi.org/10.3390/ijms232416039.
Xia, Daosong, Renwen Zheng, Jianhua Huang, Sihan Lu, and Qingfeng Tang. "Identification and Functional Analysis of Glutathione S-Transferases from Sitophilus zeamais in Olfactory Organ." Insects 13, no. 3 (March 5, 2022): 259. http://dx.doi.org/10.3390/insects13030259.
Thakur, Priti, Jowad Atway, Patrick A. Limbach, and Balasubrahmanyam Addepalli. "RNA Cleavage Properties of Nucleobase-Specific RNase MC1 and Cusativin Are Determined by the Dinucleotide-Binding Interactions in the Enzyme-Active Site." International Journal of Molecular Sciences 23, no. 13 (June 24, 2022): 7021. http://dx.doi.org/10.3390/ijms23137021.
Milot, Marie-Michelle, and Adrian Hofmann. "Shikimate kinase-like 1 plays an integral role in chloroplast biogenesis." Acta Crystallographica Section A Foundations and Advances 70, a1 (August 5, 2014): C452. http://dx.doi.org/10.1107/s2053273314095473.
Venkatraman, Janani, Jyothi Bhat, Suresh M. Solapure, Jatheendranath Sandesh, Debasmita Sarkar, Sundaram Aishwarya, Kakoli Mukherjee, et al. "Screening, Identification, and Characterization of Mechanistically Diverse Inhibitors of the Mycobacterium Tuberculosis Enzyme, Pantothenate Kinase (CoaA)." Journal of Biomolecular Screening 17, no. 3 (November 15, 2011): 293–302. http://dx.doi.org/10.1177/1087057111423069.
N'Diaye, Elsa-Noah, Aylin C. Hanyaloglu, Kimberly K. Kajihara, Manojkumar A. Puthenveedu, Ping Wu, Mark von Zastrow, and Eric J. Brown. "The Ubiquitin-like Protein PLIC-2 Is a Negative Regulator of G Protein-coupled Receptor Endocytosis." Molecular Biology of the Cell 19, no. 3 (March 2008): 1252–60. http://dx.doi.org/10.1091/mbc.e07-08-0775.
Pallen, C. J., D. S. Y. Lai, H. P. Chia, I. Boulet, and P. H. Tong. "Purification and characterization of a higher-molecular-mass form of protein phosphotyrosine phosphatase (PTP 1B) from placental membranes." Biochemical Journal 276, no. 2 (June 1, 1991): 315–23. http://dx.doi.org/10.1042/bj2760315.
Powell, David W., Madhavi J. Rane, Brian A. Joughin, Ralitsa Kalmukova, Jeong-Ho Hong, Bruce Tidor, William L. Dean, et al. "Proteomic Identification of 14-3-3ζ as a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Substrate: Role in Dimer Formation and Ligand Binding." Molecular and Cellular Biology 23, no. 15 (August 1, 2003): 5376–87. http://dx.doi.org/10.1128/mcb.23.15.5376-5387.2003.
Dryuchko, Oleksandr, Natalia Bunyakina, Bogdan Korobko, Oleksandr Shefer, Kateryna Kytaihora, and Iryna Ivanytska. "SEARCH FOR WAYS OF CONTROLLED MODIFICATION OF CHARACTERISTICS OF FUNCTIONAL UNITS OF ADAPTIVE AIR PURIFICATION SYSTEMS." Bulletin of the National Technical University "KhPI". Series: Chemistry, Chemical Technology and Ecology, no. 2(6) (December 23, 2021): 34–51. http://dx.doi.org/10.20998/2079-0821.2021.02.06.
Aytenfisu, Asaminew H., Daniel Deredge, Erik H. Klontz, Jonathan Du, Eric J. Sundberg, and Alexander D. MacKerell. "Insights into substrate recognition and specificity for IgG by Endoglycosidase S2." PLOS Computational Biology 17, no. 7 (July 26, 2021): e1009103. http://dx.doi.org/10.1371/journal.pcbi.1009103.
Byrne, Dominic P., Yong Li, Pawin Ngamlert, Krithika Ramakrishnan, Claire E. Eyers, Carrow Wells, David H. Drewry, et al. "New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors." Biochemical Journal 475, no. 15 (August 14, 2018): 2435–55. http://dx.doi.org/10.1042/bcj20180266.
Lobell, Robert B., Joseph P. Davide, Nancy E. Kohl, H. Donald Burns, Wai-Si Eng, and Raymond E. Gibson. "A Cell-Based Radioligand Binding Assay for Farnesyl: Protein Transferase Inhibitors." Journal of Biomolecular Screening 8, no. 4 (August 2003): 430–38. http://dx.doi.org/10.1177/1087057103256153.
Vargas-Pérez, María de los Ángeles, Damien Paul Devos, and Guillermo López-Lluch. "An AlphaFold Structure Analysis of COQ2 as Key a Component of the Coenzyme Q Synthesis Complex." Antioxidants 13, no. 4 (April 21, 2024): 496. http://dx.doi.org/10.3390/antiox13040496.
Ma, Peilin, Raghuveer Mali, Li-Fan Zeng, Holly Martin, Baskar Ramdas, Yantao He, Emily Sims, et al. "KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML." Blood 118, no. 21 (November 18, 2011): 868. http://dx.doi.org/10.1182/blood.v118.21.868.868.
Wang, Xingdong, Jie Pei, Pengjia Bao, Chunnian Liang, Min Chu, Shaoke Guo, Ping Yan, and Xian Guo. "Identification of Yak’s TLR4 Alternative Spliceosomes and Bioinformatic Analysis of TLR4 Protein Structure and Function." Animals 11, no. 1 (December 26, 2020): 32. http://dx.doi.org/10.3390/ani11010032.
Perduca, Massimiliano, Michele Bovi, Mattia Bertinelli, Edoardo Bertini, Laura Destefanis, Maria E. Carrizo, Stefano Capaldi, and Hugo L. Monaco. "High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase." Acta Crystallographica Section D Biological Crystallography 70, no. 8 (July 25, 2014): 2125–38. http://dx.doi.org/10.1107/s1399004714012462.
ZECHEL, David L., Shouming HE, Claude DUPONT, and Stephen G. WITHERS. "Identification of Glu-120 as the catalytic nucleophile in Streptomyces lividans endoglucanase CelB." Biochemical Journal 336, no. 1 (November 15, 1998): 139–45. http://dx.doi.org/10.1042/bj3360139.
Cooper, William C., Yi Jin, and Trevor M. Penning. "Elucidation of a Complete Kinetic Mechanism for a Mammalian Hydroxysteroid Dehydrogenase (HSD) and Identification of All Enzyme Forms on the Reaction Coordinate." Journal of Biological Chemistry 282, no. 46 (September 11, 2007): 33484–93. http://dx.doi.org/10.1074/jbc.m703414200.
Purushotham, K. R., Y. Nakagawa, M. G. Humphreys-Beher, N. Maeda, and C. A. Schneyer. "Rat Parotid Gland Acinar Cell Proliferation: Signal Transduction at the Plasma Membrane." Critical Reviews in Oral Biology & Medicine 4, no. 3 (April 1993): 537–43. http://dx.doi.org/10.1177/10454411930040034001.
Diaz-Bárcena, Alba, Luis Fernandez-Pacios, and Patricia Giraldo. "Structural Characterization and Molecular Dynamics Study of the REPI Fusion Protein from Papaver somniferum L." Biomolecules 14, no. 1 (December 19, 2023): 2. http://dx.doi.org/10.3390/biom14010002.
Gómez-Melero, Sara, Fé Isabel García-Maceira, Tania García-Maceira, Verónica Luna-Guerrero, Gracia Montero-Peñalvo, Javier Caballero-Villarraso, Isaac Túnez, and Elier Paz-Rojas. "Development of a High-Throughput Calcium Mobilization Assay for CCR6 Receptor Coupled to Hydrolase Activity Readout." Biomedicines 10, no. 2 (February 10, 2022): 422. http://dx.doi.org/10.3390/biomedicines10020422.
Chao, Nan, Wen-Ting Jiang, Xue-Chun Wang, Xiang-Ning Jiang, and Ying Gai. "Novel motif is capable of determining CCR and CCR-like proteins based on the divergence of CCRs in plants." Tree Physiology 39, no. 12 (November 21, 2019): 2019–26. http://dx.doi.org/10.1093/treephys/tpz098.
Zhao, Yi, Eliud Morales Morales Dávila, Xue Li, Beiyu Tang, Ariana I. Rabinowitsch, Jose Manuel Perez-Aguilar, and Carl P. Blobel. "Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17." International Journal of Molecular Sciences 23, no. 21 (October 24, 2022): 12796. http://dx.doi.org/10.3390/ijms232112796.
Alves, Krisnna M. A., Fábio José Bonfim Cardoso, Kathia M. Honorio, and Fábio A. de Molfetta. "Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana." Medicinal Chemistry 16, no. 6 (September 7, 2020): 784–95. http://dx.doi.org/10.2174/1573406415666190712111139.
Gao, Dan, Mohamed Madi, Cherlyn Ding, Matthew Fok, Thomas Steele, Christopher Ford, Leif Hunter, and Chen Bing. "Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes." American Journal of Physiology-Endocrinology and Metabolism 307, no. 3 (August 1, 2014): E289—E304. http://dx.doi.org/10.1152/ajpendo.00430.2013.
Takacs, Gregory, Yujia Zhou, David J. King, Amy Meacham, Loguinov Alex, Abderrahmane Tagmount, Amin Sobh, Max Russo, Chris D. Vulpe, and Christopher R. Cogle. "CRISPR Dropout Screens Identify DHODH,PIK3C3, and Crkl as Potential Therapeutic Targets in Acute Myeloid Leukemia." Blood 134, Supplement_1 (November 13, 2019): 1452. http://dx.doi.org/10.1182/blood-2019-128180.
Rieger, Leonie, Kilian Irlinger, Franziska Fuechsl, Nicolas Barbian, Marlene Tietje, Melanie Faber, Tobias Schulze, et al. "Regulation of BCMA By the Ubiquitin Proteasome System Enables Optimization of BCMA-Targeting Therapies in Multiple Myeloma." Blood 142, Supplement 1 (November 28, 2023): 3310. http://dx.doi.org/10.1182/blood-2023-187349.
Mou, Peipei, Zhao Zeng, Lijie Ren, Qiang Li, Kenneth M. Wannemacher, Xi Mo, Lawrence F. Brass, and Li Zhu. "Identification of a Region within the Cytoplasmic Domain of Sema4D That Binds Calmodulin and Regulates Shedding of the Sema4D Exodomain in Platelets,." Blood 118, no. 21 (November 18, 2011): 3249. http://dx.doi.org/10.1182/blood.v118.21.3249.3249.