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1

Kim, Noheul, and Ronny Priefer. "Drug Regimen for Patients after a Pneumonectomy." Journal of Respiration 1, no. 2 (April 13, 2021): 114–34. http://dx.doi.org/10.3390/jor1020013.

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Pneumonectomy is an entire lung removal and is indicated for both malignant and benign diseases. Due to its invasiveness and postoperative complications, pneumonectomy is still associated with high mortality and morbidity. Appropriate postoperative management is crucial in pneumonectomy patients to improve quality of life and overall survival rates. Diverse drug regimens are under development to be used in adjuvant chemotherapy or to improve respiratory health after a pneumonectomy. The most common causes for a pneumonectomy are non-small cell lung cancer, malignant pleural mesothelioma, and tuberculosis; thus, an appropriate drug regimen is necessary. The uncommon incidence of pneumonectomy cases remains the major obstacle in studies of postoperative drug regimens. As the majority of current studies include post-lobectomy and post-segmentectomy patients, it is highly recommended that further research of postoperative drug regimens be focused on post-pneumonectomy patients.
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2

Kanjanauthai, Somsupha, Tony Kanluen, and Michael Bergman. "Tension Chylothorax: A Rare Life Threatening Entity After Pneumonectomy." Heart, Lung and Circulation 18, no. 1 (February 2009): 55–56. http://dx.doi.org/10.1016/j.hlc.2007.10.001.

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3

Leo, Francesco, Paolo Scanagatta, Fernando Vannucci, Daniela Brambilla, Davide Radice, and Lorenzo Spaggiari. "Impaired quality of life after pneumonectomy: Who is at risk?" Journal of Thoracic and Cardiovascular Surgery 139, no. 1 (January 2010): 49–52. http://dx.doi.org/10.1016/j.jtcvs.2009.05.029.

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4

Karasaki, Takahiro, and Makoto Tanaka. "Life-Threatening Postpneumonectomy Syndrome Complicated with Right Aortic Arch after Left Pneumonectomy." Case Reports in Surgery 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/768067.

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A 54-year-old man with right aortic arch underwent left lower lobectomy and lingular segmentectomy, followed by complete pneumonectomy, for refractory nontuberculous mycobacterial infection. Three months after the pneumonectomy, he developed acute respiratory distress. Computed tomography showed an excessive mediastinal shift with an extremely narrowed bronchus intermedius and right lower bronchus compressed between the right pulmonary artery and the right descending aorta. Soon after the nearly obstructed bronchus intermedius was observed by bronchoscopy, he began to exhibit frequent hypoxic attacks, perhaps due to mucosal edema. Emergent surgical repositioning of the mediastinum and decompression of the bronchus was indicated. After complete adhesiolysis of the left thoracic cavity was performed, to maintain the proper mediastinal position, considering the emergent setting, an open wound thoracostomy was created and piles of gauze were inserted, mildly compressing the heart and the mediastinum to the right side. Thoracoplasty was performed three months later, and he was eventually discharged without any dressings needed. Mediastinal repositioning under thoracostomy should be avoided in elective cases because of its extremely high invasiveness. However, in the case of life-threatening postpneumonectomy syndrome in an emergent setting, mediastinal repositioning under thoracostomy may be an option to save life, which every thoracic surgeon could attempt.
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5

Bryant, Ayesha S., Robert J. Cerfolio, and Douglas J. Minnich. "Survival and quality of life at least 1 year after pneumonectomy." Journal of Thoracic and Cardiovascular Surgery 144, no. 5 (November 2012): 1139–45. http://dx.doi.org/10.1016/j.jtcvs.2012.07.083.

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6

Toneev, E. A., O. V. Pikin, V. I. Orelkin, A. L. Charyshkin, A. A. Martynov, Ya M. Remizova, and P. M. Chavkin. "EVALUATION OF THE QUALITY OF LIFE IN PATIENTS WITH LUNG CARCINOMA AFTER PNEUMONECTOMY." Siberian journal of oncology 20, no. 3 (June 29, 2021): 90–97. http://dx.doi.org/10.21294/1814-4861-2021-20-3-90-97.

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Background. Pneumonectomy is one of the most traumatic thoracic surgeries, leading to a significant decrease in the patient’s functional status. Despite numerous questionnaires, there is no standard approach to the study of the quality of life of patients who have undergone radical surgery for lung cancer.The purpose of the study was to conduct a retrospective analysis of the quality of life of patients who underwent pneumonectomy during the period 2017–2018, taking into account the extent of surgery, presence of concomitant disease and adjuvant antitumor treatment.Material and Methods. Changes in the quality of life (qol) during combined modality treatment were evaluated in 40 patients with non-small cell lung cancer. To assess the functional status, the criteria adopted for determining the surgical risk were used. The st. George`s Respiratory Questionnaire (sgrq) and Quality Outcomes study short-Form 36 (sf-36) were used to assess the respiratory system of patients. Data collection was carried out 12 months after surgery using a questionnaire method based on a direct survey of respondents.Conclusion. Postoperative special treatment significantly worsens both the functional parameters of patients and the quality of life. Thus, a multidisciplinary approach to the management of patient with participation of an oncologist, pulmonologist, physiotherapist, and rehabilitologist is required.
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7

Sartipy, Ulrik. "Prospective population-based study comparing quality of life after pneumonectomy and lobectomy☆." European Journal of Cardio-Thoracic Surgery 36, no. 6 (December 2009): 1069–74. http://dx.doi.org/10.1016/j.ejcts.2009.05.011.

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8

Ambrogi, Vincenzo, Davide Mineo, Antonio Gatti, Eugenio Pompeo, and Tommaso C. Mineo. "Symptomatic and quality of life changes after extrapleural pneumonectomy for malignant pleural mesothelioma." Journal of Surgical Oncology 100, no. 3 (September 1, 2009): 199–204. http://dx.doi.org/10.1002/jso.21261.

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9

Postmus, PE, JM Kerstjens, WJ de Boer, JN Homan van der Heide, and GH Koeter. "Treatment of post pneumonectomy pleural empyema by open window thoracostomy." European Respiratory Journal 2, no. 9 (October 1, 1989): 853–55. http://dx.doi.org/10.1183/09031936.93.02090853.

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In 13 patients an open window thoracostomy (OWT) was performed for post pneumonectomy pleural empyema. The operation, and life with an OWT cavity, were tolerated well. Early closure of an OWT is not advisable because of a high chance of recurrence of the infection and, in lung cancer patients also the risk of tumour relapse within two years after tumour surgery.
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10

Marek, Szkorupa, Simek Martin, Zuscich Ondrej, Chudacek Josef, Neoral Cestmir, and Lonsky Vladimir. "Extracorporeal membrane oxygenation in the management of post-pneumonectomy air leak and adult respiratory distress syndrome of the non-operated lung." Perfusion 32, no. 5 (January 30, 2017): 416–18. http://dx.doi.org/10.1177/0267659117690247.

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Post-pneumonectomy air leak and severe respiratory failure of the non-operated lung is considered to be a life-threatening complication of lung surgery. We present the case report of a 68-year-old man who underwent a right pneumonectomy for spinocellular carcinoma. Refractory respiratory failure occurred following bronchial stump air leakage and adult respiratory distress syndrome (ARDS) of the non-operated lung. Established veno-venous extracorporeal membrane oxygenation (VV ECMO) was utilized to maintain tissue oxygenation while re-do surgery was performed. The leaking bronchial stump was closed with an azygos vein patch and, subsequently, weaning off ECMO was accomplished 7 days later. The patient fully recovered and he is limited only by mild exertional dyspnea at 24 months follow-up after the initial surgery.
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11

Petrov, Danail B., Dragan Subotic, Georgi S. Yankov, Dinko G. Valev, and Evgeni V. Mekov. "Epidemiology, etiology and prevention of postpneumonectomy pleural empyema." Folia Medica 61, no. 3 (September 30, 2019): 352–57. http://dx.doi.org/10.3897/folmed.61.e39120.

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Background: Pleural empyema after pneumonectomy still poses a serious postoperative complication. A broncho-pleural fistula is often detected. Despite various therapeutic options developed over the last five decades it remains a major surgical challenge. Materials and methods: A literature search in MEDLINE database was carried out (accessed through PubMed), by using a combination of the following key-words and MeSH terms: pneumonectomy, postoperative, complications, broncho-pleural fistula, empyema, prevention. The following areas of intervention were identified: epidemiology, etiology, prevention. Results: Pleural empyema in a post-pneumonectomy cavity occurs in up to 16% of patients with a mortality of more than 10%. It is associated with broncho-pleural fistula in up to 80% of them, usually in the early postoperative months. Operative mortality could reach 50% in case of broncho-pleural fistula. Unfavourable prognostic factors are: benign disease, COPD, right-sided surgery, neoadjuvant and adjuvant therapy, time of chest tube removal, long bronchial stump and mechanical ventilation. Bronchial stump protection with vascularised flaps is of utmost importance in the prevention of complications. Conclusion: Postpneumonectomy pleural empyema is a common complication with high mortality. The existing evidence confirms the role of bronchopleural fistula prevention in the prevention of life-threatening complications.
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12

Mir, Izza, Sijan Basnet, David Ellsworth, and Elan Mohanty. "Pulmonary Mucormycosis in Chronic Lymphocytic Leukemia and Neutropenia." Case Reports in Infectious Diseases 2018 (2018): 1–4. http://dx.doi.org/10.1155/2018/2658083.

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Pulmonary mucormycosis is a rare life-threatening fungal infection associated with high mortality. We present the case of a 61-year-old man with history of chronic lymphocytic leukemia who presented with fever and cough, eventually diagnosed with pulmonary mucormycosis after right lung video-assisted thoracoscopic surgery. The patient was successfully treated with amphotericin B and right lung pneumonectomy; however, he later died from left lung pneumonia.
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13

Shefer, N. A., and E. B. Topolnitskiy. "Immediate results of organ-preserving anatomical resections and pneumonectomy in elderly and senile patients with lung cancer." Siberian Medical Review, no. 5 (2022): 63–69. http://dx.doi.org/10.20333/25000136-2022-5-63-69.

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The aim of the research. The aim of the study was to conduct a comparative analysis of the immediate results of organ-preserving anatomical resections and pneumonectomy in elderly and senile patients with lung cancer. Material and methods. The study included 126 patients over 60 years of age, who were divided into 2 groups depending on the extent of the surgical intervention performed. Group A was represented by 63 patients who underwent organ-preserving anatomical resections and group B enrolled 63 patients after pneumonectomy. The groups were formed through retrospective analysis of prospective data obtained from the electronic registry. In all cases, the comorbid background was assessed, as well as options for preoperative correction of the concomitant pathology. In the postoperative period, the number and severity of complications were assessed using the TMM (Thoracic Morbidity and Mortality) System, and an intergroup comparative statistical analysis was performed. Results. According to the results of the study, postoperative complications among patients in group A were recorded in 22 (34.9%) cases, mortality was established in 4 (6.35%) patients. In group B, the number of complications and mortality were registered in 18 (28.6%) and 6 (9.52%) cases, respectively. Among the complications registered in group A, the most common were prolonged air discharge through the drainage and cardiac arrhythmias. In the group after pneumonectomy, complications associated with arrhythmia also prevailed, while the complication occurred statistically more often. Among the lethal outcomes in both groups, the main cause was progressive cardiovascular insufficiency against the background of arrhythmia, as well as failure of the bronchus stump and suture. Conclusion. Despite the absence of reliable differences in the total number of complications and mortality in the groups, there is a clear trend towards a higher frequency of fatal complications in the group after pneumonectomy. A feature was noted in the continuing risk of mortality, regardless of the severity of the complication. Among patients after organ-preserving anatomical resections, reversible deviations from the normal course in the postoperative period prevail. In addition, this extent of surgical intervention provides for better functionality and quality of life to elderly and senile patients.
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14

Balduyck, Bram, Jeroen Hendriks, Patrick Lauwers, and Paul Van Schil. "Quality of Life after Lung Cancer Surgery: A Prospective Pilot Study comparing Bronchial Sleeve Lobectomy with Pneumonectomy." Journal of Thoracic Oncology 3, no. 6 (June 2008): 604–8. http://dx.doi.org/10.1097/jto.0b013e318170fca4.

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15

Skrzypczak, Piotr J., Magdalena Roszak, Mariusz Kasprzyk, Anna Kopczyńska, Piotr Gabryel, and Wojciech Dyszkiewicz. "Pneumonectomy – permanent injury or still effective method of treatment? Early and long-term results and quality of life after pneumonectomy due to non- small cell lung cancer." Polish Journal of Cardio-Thoracic Surgery 16, no. 1 (2019): 7–12. http://dx.doi.org/10.5114/kitp.2019.82966.

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16

Balduyck, Bram, Jeroen Hendriks, Patrick Lauwers, and Paul Van Schil. "B6-03: Quality of life after lung cancer surgery: a prospective study comparing bronchial sleeve lobectomy with pneumonectomy." Journal of Thoracic Oncology 2, no. 8 (August 2007): S351. http://dx.doi.org/10.1097/01.jto.0000283176.78555.90.

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17

Teschner, M. "Rupture of the thoracic aorta descendens following Dacron patch infection: a rare, life-threatening complication after extensive pneumonectomy." Gefässchirurgie 4, no. 2 (1999): 96. http://dx.doi.org/10.1007/s007720050127.

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18

Kopeika, Uldis, Immanuels Taivans, Sanita Ūdre, Nataļja Jakušenko, Gunta Strazda, and Māris Mihelsons. "Effects of the prolonged thoracic epidural analgesia on ventilation function and complication rate after the lung cancer surgery." Medicina 43, no. 3 (October 2, 2006): 199. http://dx.doi.org/10.3390/medicina43030024.

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Thoracic epidural analgesia has been considered to have a good anesthetic efficacy and to decrease the postoperative complication rate, while its effect upon the ventilation function is still the topic of many clinical studies. The aim of this study was to evaluate the course of early postoperative period using thoracic epidural analgesia. Material and methods. A total of 453 patients undergoing the operation due to the non–small cell carcinoma were selected and examined. Their postoperative complications and mortality rate were evaluated. In 79 patients, arterial oxygen saturation (SaO2), forced vital capacity, forced expiratory volume in the first second, and the efficacy of analgesia were analyzed within the first 7 days after the operation. These patients were divided into subgroups according to the type of the operation – lobectomy or pneumonectomy – and the type of analgesia – thoracic epidural analgesia or opiates administered intramuscularly (control group). Results. A better statistically significant efficacy of analgesia was observed in thoracic epidural analgesia group than in the control group (visual analog pain scale score 2.5 versus 5.3, P<0.01). There was also a statistically significant lower incidence of postoperative complications (20.5% versus 38.8%, respectively). Thoracic epidural analgesia is a factor decreasing the relative risk of complications (RR=0.53, 95% CI 0.28–0.99, P=0.0233). In the lobectomy group, 24 hours after the surgery, forced vital capacity was 61±12% in the group receiving thoracic epidural analgesia and 45±13% in the control group (P=0.0152); forced expiratory volume in the first second was 56±17% and 41±11%, respectively (P=0.0308). In the pneumonectomy group, 24 hours after the surgery, forced vital capacity was 47±16% in the group receiving thoracic epidural analgesia, 35±8% in the control group (P=0.080). Forced expiratory volume in the first second was 47±15% and 36±7%, respectively (P=0.0449). Conclusion. We conclude that analgesia with intramuscularly administered opioids provides unsatisfactory analgesia, especially in the first days after the operation. Thoracic epidural analgesia is a safe method, which provides a better quality of life for the patient, decreases the postoperative complication rate, and improves the ventilation function after the lung operations.
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19

Ayabe, Takanori, Tetsuya M. Shimizu, Masaki Tomita, Mitsuhiro Yano, Kunihide Nakamura, and Toshio Onitsuka. "Emergent Completion Pneumonectomy for Postoperative Hemorrhage from Rupture of the Infected Pulmonary Artery in Lung Cancer Surgery." Case Reports in Surgery 2011 (2011): 1–4. http://dx.doi.org/10.1155/2011/902062.

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Completion pneumonectomy (CP) is one of the most difficult procedures and known to be associated with a high morbidity and mortality. A 74-year-old male underwent a left upper lobectomy for pulmonary adenocarcinoma (T3N0M0); six days later after the surgery, he had a sudden postoperative intrathoracic excessive hemorrhage with shock. Emergent redo thoracotomy was performed to treat the bleeding from the ablated interlobar pulmonary artery by suturing with prolene. However, 3 days later after the second operation, he had the second intrathoracic bleeding. Emergent CP was performed with cardiopulmonary bypass by anterior transpericarsial approach via a median sternotomy. The hemorrhage was caused by a rupture of the proximal fragile and infected pulmonary artery. We performed omentopexy for the infected intrathoracic cavity and for covering of the divided main bronchial stump. We had a rare experience of two times of postoperative life-threatening hemorrhage from rupture of the infected pulmonary artery after left upper lobectomy. Emergent CP as salvage surgery should have an advantage in control of infected proximal pulmonary arterial hemorrhage. We should take care of tearing off of adventitia of pulmonary artery in lobectomy because of a possibility of postoperative hemorrhage under a fragility of the injured pulmonary artery with infection.
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20

Abraham, Manoj T., Manjit S. Bains, Robert J. Korst, Robert J. Downey, and Dennis H. Kraus. "Type I Thyroplasty for Acute Unilateral Vocal Fold Paralysis following Intrathoracic Surgery." Annals of Otology, Rhinology & Laryngology 111, no. 8 (August 2002): 667–71. http://dx.doi.org/10.1177/000348940211100802.

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Patients who undergo intrathoracic operative procedures for malignancy may require sacrifice of a recurrent laryngeal nerve. Postoperative vocal fold paralysis may lead to diminished cough with secretion retention, aspiration, and life-endangering pneumonia. This study retrospectively reviews our institution's experience of 23 patients who underwent type I thyroplasty within the 2-week (acute) period after thoracic surgery. Primary lung cancer (n = 16) was the most common disease. Upper lobectomy (n = 9) and pneumonectomy (n = 7) were the most frequent surgical procedures. Silicone medialization alone (n = 11) or with arytenoid adduction (n = 12) was performed. There were no significant postoperative complications. Improvements in hoarseness (86%), dyspnea (72%), dysphagia (50%), and aspiration (79%) were noted. Pulmonary status improved after vocal fold medialization, as reflected by decreased need for therapeutic bronchoscopy in the majority of patients in the postoperative period. Type I thyroplasty for vocal fold paralysis in the acute phase following thoracic surgery is well tolerated and is associated with improved patient outcome with no postoperative deaths in this high-risk patient population.
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21

Lee, Dong-Seok, Andrea Carollo, Naomi Alpert, Emanuela Taioli, and Raja Flores. "VATS Pleurectomy Decortication Is a Reasonable Alternative for Higher Risk Patients in the Management of Malignant Pleural Mesothelioma: An Analysis of Short-Term Outcomes." Cancers 13, no. 5 (March 3, 2021): 1068. http://dx.doi.org/10.3390/cancers13051068.

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Surgery is a mainstay of treatment allowing for debulking of tumor and expansion of the lung for improvement in median survival and quality of life for patients with malignant pleural mesothelioma (MPM). Although optimal surgical technique remains open for debate—extrapleural pneumonectomy (EPP) vs. pleurectomy/decortication (P/D)—minimally invasive surgery (VATS-P/D) remains underutilized in the management of MPM. We examined whether VATS-P/D is a feasible alternative to EPP and P/D. We evaluated the New York Statewide Planning and Research Cooperative System (SPARCS) from 2007–2017 to assess the short-term complications of EPP vs. P/D, including a subanalysis of open P/D vs. VATS-P/D. There were 331 patients with open surgery; 269 with P/D and 62 with EPP. There were 384 patients with P/D; 269 were open and 115 VATS. Rates of any complication were similar between EPP and P/D patients, but EPP had significantly higher rates of cardiovascular complications. After adjusting for confounders, those with a VATS approach were less likely to have any complication, compared to an open approach and significantly less likely to have a pulmonary complication. VATS-P/D remains a viable alternative to radical surgery in MPM patients allowing for improved short-term outcomes.
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22

Li, Xiaobing, Shuai Wang, Meipan Yin, Xiangnan Li, Yu Qi, Yaozhen Ma, Chunxia Li, and Gang Wu. "Treatment of peripheral bronchopleural fistula with interventional negative pressure drainage." Therapeutic Advances in Respiratory Disease 16 (January 2022): 175346662211118. http://dx.doi.org/10.1177/17534666221111877.

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Objectives: Bronchopleural fistula is a serious complication of pneumonectomy and lobectomy and results in a reduction in the quality of life of patients. This study aimed to evaluate the efficacy and safety of percutaneous drainage tube placement with continuous negative pressure drainage for the treatment of peripheral bronchopleural fistula. Methods: Data of 16 patients with peripheral bronchopleural fistula were retrospectively analyzed. A percutaneous thoracic drainage tube was placed under fluoroscopy and connected with a negative pressure suction device. The drainage tube was removed when the residual cavity disappeared on computed tomography. Results: All 16 patients underwent lobectomy, including 11 patients with lung cancer (68.8%), 4 patients with pulmonary infection (25.0%), and 1 patient with hemoptysis (6.3%). All patients underwent successful drainage tube placement on the first attempt with a technical success rate of 100%. No serious complications occurred during or after the procedure. The drainage tubes were adjusted 3.25 ± 2.24 times (range: 1–8 times). A total of 30 drainage tubes were used (average per patient, 1.88 ± 1.36 tubes). The cure time of 16 patients was 114.94 ± 101.08 days (range, 30–354 days). The median drainage tube indwelling duration was 87 days, and the 75th percentile was 117 days. Conclusion: Interventional percutaneous thoracic drainage tube placement with continuous negative pressure drainage is an effective, safe, and feasible method for the treatment of peripheral bronchopleural fistula.
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23

Kit, O. I., I. N. Turkin, D. A. Kharagezov, Yu N. Lazutin, I. A. Leiman, A. V. Chubaryan, and E. A. Mirzoyan. "Sequential bronchoplastic upper lobectomy as a surgical component of multimodal treatment for synchronous bilateral multiple primary non-small cell lung cancer." Siberian journal of oncology 21, no. 3 (June 29, 2022): 143–50. http://dx.doi.org/10.21294/1814-4861-2022-21-3-143-150.

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Relevance. Lung cancer (LC) is the leading cause of cancer-related death worldwide including Russia. Surgery remains the standard of care for early non-small cell lung cancer (NSCLC). However, as the disease progresses, the risk of metastasis increases, and the effectiveness of surgical intervention decreases. The treatment strategy for patients presenting with a single NSCLC has long been developed. However, for patients with two or more tumors, especially in both lungs, the correct choice is determined by many additional factors. Currently, the view on the surgical treatment for synchronous multiple primary NSCLC has changed dramatically. However, patients with locally advanced synchronous NSCLC often receive conservative treatment, and for those who do undergo surgery, the prognostic factors are unclear. The disease prognosis in patients after surgical treatment for bilateral synchronous multiple primary NSCLC has now been proven to be favorable. Pneumonectomy is believed to have no any negative effect on survival; however, several authors reported on a 1.5-2-fold increase in postoperative mortality in a series of surgeries for synchronous NSCLC. Case description. We herein report a case in which extended bronchoplastic upper lobectomy was successfully applied in the treatment of a patient with bilateral synchronous NSCLC. Our experience demonstrates that the sequential application of modern therapeutic modalities results in satisfactory long-term outcomes in the treatment of locally advanced LC.Conclusion. Due to its uniqueness, this clinical case will be useful for developing treatment strategy for synchronous locally advanced NSCLC as well as for improving the quality of life of patients and increasing their survival.
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Keshava-Prasad, Holavanahalli, Krishna Oza, Girindra Raval, and Tamim Antakli. "Management of Intractable Bleeding after Cardiac Surgery with Recombinant Activated Factor VII." Blood 112, no. 11 (November 16, 2008): 4526. http://dx.doi.org/10.1182/blood.v112.11.4526.4526.

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Abstract Background Intractable hemorrhage is a dreaded complication after cardiovascular surgery often requiring re-exploration and the administration of large quantities of blood products. In view of problems with aprotinin, a new safer effective agent is needed. Recombinant activated FVII is approved for use in patients with hemophilia A and B who have inhibitors to factors VIII and IX, and has shown promise in off-label use for the management of life-threatening hemorrhage in several clinical scenarios including cardiac surgery. It may help control bleeding, reduce blood product usage, and avoid potential morbidity. Its exact place in the management of bleeding during and after cardiac surgery is not yet fully known. Methods. We performed a retrospective review of patients who were given recombinant factor VIIa (rFVIIa; Novoseven, NovoNordisk, Copenhagen, Denmark) to control bleeding after major cardiovascular surgery requiring cardiopulmonary bypass (CPB) at our institution. The decision to administer rFVIIa was made empirically based on the observation by the surgeons of refractory bleeding that appeared unresponsive to conventional hemostasis agents including the requirement of large volumes of blood components, and was at least severe enough to prevent chest closure. We compared blood loss and blood component usage in patients before and after rFVIIa. We also performed a detailed review of the English literature to determine the role of rFVIIa in the treatment of bleeding after cardiac surgery. Results. Between August 2002 to February 2006, 1295 patients underwent open heart surgery at our institution; of these, 28 were given Novoseven either to control intractable bleeding, or to prevent major bleeding. Table 1 shows the patient characteristics. Satisfactory hemostasis was achieved in all but 3 patients after a single 90 μg/kg intravenous dose of rFVIIa. In all patients, there was a dramatic reduction in the amount of blood components (PRBCs, Platelets and FFP) used after rFVIIa infusion (Table 2). Cryoprecipitate was administered routinely with rFVIIa and its usage did not change significantly (Table 2). No thromboembolic or other complications directly related to rVIIa occurred. Conclusions. We have demonstrated that intravenous rFVIIa is effective, safe, and valuable in the management of intractable bleeding after complicated cardiac surgeries. There are several reports and reviews in the literature which corroborate our experience and indicate that recombinant factor VIIa is a potent pro-hemostatic agent which has a role in the treatment of life-threatening refractory hemorrhage associated with cardiac surgery. Earlier preemptive administration of rFVIIa during or before surgery may be of value in patients at high risk of intractable bleeding in order to limit blood loss, and to avoid potential morbidity from large volume blood component transfusions. Randomized, controlled trials are warranted to assess the efficacy, safety, and cost-benefit of this intervention in cardiac surgical patients. TABLE 1. Characteristics and operative course of the 28 patients Mean age 60 yrs (range 22–85) Male, M 24(85%); F 4(15%) Total number of surgical procedures performed: 34 Aortic valve: 7; Bentall or modified Bentall: 9 (3 emergent) Mitral Valve Replacement: 4; CABG: 10; Redo 2 Left pneumonectomy/resection of L Atrial cuff & pericardium: 1 Removal of Inferior vena cava tumor (Renal cell ca): Re-exploration: 6; Delayed closure: 5; Both re-exploration and delayed closure: Median bypass time: 214 min (65–358) Timing of Novoseven: intra op: 21 including elective use in 2 pts; post op: 7 Dose of Novoseven: 90mcg/kg in 22; 45 mcg/kg 2 patients Responders 25(89%) Outcome: Deaths 11(38%) Autopsies: 2; no evidence of systemic thrombosis Table 2. Details of the blood products administered both before and after rFVIIa infusion. Componen Mean units Before rVIIa Mean units After rVIIa Difference; p value PRBC usage 15.9 5.033333 0.045 Platelet usage 4.448276 1.37931 0.005 FFP Usage 9.931034 5.793103 0.042 Cryoppt 21.71429 12.54167 0.091
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Bhandari, Shanker, Dinesh Gurung, Kazi Saiful Lslam, Razzaque, Md Aftabuddin, and Asit Baran Adhikary. "Surgical management of bronchiectasis." Bangabandhu Sheikh Mujib Medical University Journal 8, no. 2 (July 26, 2016): 114. http://dx.doi.org/10.3329/bsmmuj.v8i2.28933.

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<p><strong>Background:</strong> Bronchiectasis is the permanent dilatation of the bronchi due to destruction of bronchial wall. Bronchi­ectasis still remains a serious problem in developing countries despite of modern medical facilities.</p><p><strong>Objectives:</strong> This study aims to demonstrate our surgical experience for bronchiectasis and analyze the risk factors related with the surgery outcome.</p><p><strong>Methods:</strong> Hospital based analyses of 39 patients were done who were underwent surgery for bronchiectasis and were on follow up in National Institute of Diseases of Chest hospital (NIDCH) in September 2014 to February 2015 were included in this study. All 39 patients had surgery for the bronchiectasis in the period of January 2014 to December 2014.</p><p><strong>Results:</strong> The mean age of the patients were 22.2 years. Twenty four patients were females and 15 were male. Symptoms were recurrent infection with cough, copious sputum in all patients and hemoptysis in 31 patients. The etiology was recur­rent childhood infection in 17 patients, pneumonia in 11 patients, PTB in 6 patients, Aspiration in 2 patients, foreign body obstruction in 1 patient, and unknown etiology in 2 patients. Chest x-ray, CT scan and rigid bronchoscope were done for all patients. Bronchiectasis was left-sided in 17 patients. It was mainly confined to the lower lobes either alone in 9 patients and in conjunction with middle lobe or lingual in 8 patients. Indications for resection were failure of conservative therapy in 22 patients, hemoptysis in 8 patients, destroyed lung in 9 patients. Surgery was lobectomy in 24 patients, Bilobectomy in 5 patients, and pneumonectomy in 10 patients. Complications occurred in 10 patients with no operative mortality. Thirty four patients had relief of their preoperative symptoms after surgery in follow up periods.</p><p><strong>Conclusions:</strong> Surgical resection for bronchiectasis should be reserved for patients with localised disease who have failed medical management and have persistent symptoms that negatively affect their quality of life.</p>
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Forero, Mauricio, Manikandan Rajarathinam, Sanjib Adhikary, and Ki Jinn Chin. "Erector spinae plane (ESP) block in the management of post thoracotomy pain syndrome: A case series." Scandinavian Journal of Pain 17, no. 1 (October 1, 2017): 325–29. http://dx.doi.org/10.1016/j.sjpain.2017.08.013.

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AbstractBackground and aimsPost thoracotomy pain syndrome (PTPS) remains a common complication of thoracic surgery with significant impact on patients’ quality of life. Management usually involves a mul¬tidisciplinary approach that includes oral and topical analgesics, performing appropriate interventional techniques, and coordinating additional care such as physiotherapy, psychotherapy and rehabilitation. A variety of interventional procedures have been described to treat PTPS that is inadequately managed with systemic or topical analgesics. Most of these procedures are technically complex and are associated with risks and complications due to the proximity of the targets to neuraxial structures and pleura. The ultrasound-guided erector spinae plane (ESP) block is a novel technique for thoracic analgesia that promises to be a relatively simple and safe alternative to more complex and invasive techniques of neural blockade. We have explored the application of the ESP block in the management of PTPS and report our preliminary experience to illustrate its therapeutic potential.MethodsThe ESP block was performed in a pain clinic setting in a cohort of 7 patients with PTPS following thoracic surgery with lobectomy or pneumonectomy for lung cancer. The blocks were performed with ultrasound guidance by injecting 20–30mL of ropivacaine, with or without steroid, into a fascial plane between the deep surface of erector spinae muscle and the transverse processes of the thoracic vertebrae. This paraspinal tissue plane is distant from the pleura and the neuraxis, thus minimizing the risk of complications associated with injury to these structures. The patients were followed up by telephone one week after each block and reviewed in the clinic 4–6 weeks later to evaluate the analgesic response as well as the need for further injections and modification to the overall analgesic plan.ResultsAll the patients had excellent immediate pain relief following each ESP block, and 4 out of the 7 patients experienced prolonged analgesic benefit lasting 2 weeks or more. The ESP blocks were combined with optimization of multimodal analgesia, resulting in significant improvement in the pain experience in all patients. No complications related to the blocks were seen.ConclusionThe results observed in this case series indicate that the ESP block may be a valuable therapeutic option in the management of PTPS. Its immediate analgesic efficacy provides patients with temporary symptomatic relief while other aspects of chronic pain management are optimized, and it may also often confer prolonged analgesia.ImplicationsThe relative simplicity and safety of the ESP block offer advantages over other interventional procedures for thoracic pain; there are few contraindications, the risk of serious complications (apart from local anesthetic systemic toxicity) is minimal, and it can be performed in an outpatient clinicsetting. This, combined with the immediate and profound analgesia that follows the block, makes it an attractive option in the management of intractable chronic thoracic pain. The ESP block may also be applied to management of acute pain management following thoracotomy or thoracic trauma (e.g. rib fractures), with similar analgesic benefits expected. Further studies to validate our observations are warranted.
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Jackevičius, Algirdas, Saulius Cicėnas, and Dainius Piščikas. "Plaučių metastazių chirurginio gydymo rezultatai." Lietuvos chirurgija 1, no. 4 (January 1, 2003): 0. http://dx.doi.org/10.15388/lietchirur.2003.4.2391.

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Algirdas Jackevičius, Saulius Cicėnas, Dainius PiščikasVilniaus universiteto Onkologijos institutoTorakalinės chirurgijos ir onkologijos skyriusSantariškių g. 1, LT-2600 VilniusEl paštas: algirdasj@is.lt Įvadas / tikslas Apie plaučių metastazių iš kitų organų gydymą esama įvairių nuomonių. Norime pasidalyti savo patirtimi, susijusia su chirurginiu plaučių metastazių gydymu. Straipsnyje aprašome plaučių metastazių gydymo taktiką, pateikiame vėlyvuosius gydymo rezultatus. Ligoniai ir metodai Straipsnyje nagrinėjami 1998–2002 metais gydyti 168 ligoniai, kuriems buvo diagnozuotos kitų organų navikų metastazės plaučiuose. Tarp jų buvo 81 vyras ir 87 moterys. Vyrų amžiaus vidurkis – 55,4 metų (jauniausias – 23, vyriausias – 83 metų). Moterų amžiaus vidurkis – 48,5 metų (jauniausia – 23, vyriausia – 77 metų). Moterų plaučių metastazių priežastys buvo tokios: krūties vėžys – 37 atvejai, kiaušidžių – 9, gimdos – 8, inkstų – 8, kito plaučio – 5, kepenų – 3, gaubtinės žarnos – 3, tiesiosios žarnos – 3, minkštųjų audinių sarkomos – 3, melanoma – 2; nosiaryklės, skrandžio, kaulų sarkomos, skydliaukės navikų buvo po vieną atvejį. Dažniausios vyrų plaučių metastazių priežastys buvo šių organų ir audinių navikai: inksto – 17 atvejų, kito plaučio – 13, sėklidžių – 9, gerklų – 6, tiesiosios žarnos – 5, kaulų sarkomų – 4, skydliaukės – 5, prostatos – 5, gaubtinės žarnos – 4, minkštųjų audinių – 3, skrandžio – 2, antinksčių – 2, melanomos, burnos ertmės, šlapimo pūslės – po vieną atvejį. Ligoniams buvo atliktos šios operacijos: pulmonektomija – 5, lobektomija – 31, segmentektomija – 40, atipinė plaučių rezekcija – 14, metastazių pašalinimas – 11, torakotomija – 26. Videotorakoskopija ir talko insufliacija atlikta 38 ligoniams. Po operacijos 12 ligonių buvo papildomai gydyti chemoterapija ir aktinoterapija. Rezultatai Nuo vėžio progresavimo mirė 40 ligonių. Jų vidutinė gyvenimo trukmė po operacijos – 7,3 mėn. (minimali – 1, maksimali – 27 mėn.). Operacijos apimtis turėjo įtakos ligonių gyvenimo trukmei. Po lobektomijų vidutinė ligonių gyvenimo trukmė buvo 12,4 mėn., po segmentektomijų – 10,2 mėn., po atipinių plaučių rezekcijų – 10,5 mėn. Ligoniai, kuriems buvo atliktos tik torakotomijos (kai nebuvo galimybės pašalinti metastazių), išgyveno vidutiniškai 8,5 mėn. Blogiausi gydymo rezultatai buvo tais atvejais, kai parietalinėje ir visceralinėje pleuroje buvo matoma daug metastazių ir tokio navikinio pleuros pažeidimo sąlygomis buvo konstatuojamas vėžinis pleuritas. Po videotorakoskopijų, kurių metu buvo patikslinama pleurito priežastis ir atliekama talko insufliacija į pleuros ertmę, ligonių gyvenimo vidutinė trukmė buvo mažiausia – 3,4 mėnesio. Išvados Pavienių plaučių metastazių chirurginis šalinimas pailgina ligonių gyvenimo trukmę. Geriausi gydymo rezultatai gauti chirurgiškai pašalinus kolorektinio ir inksto vėžio ligonių plaučių pavienes metastazes. Blogiausi gydymo rezultatai buvo ligonių, sergančių kiaušidžių, krūties vėžiu ir melanoma, nes joms dažniausiai atsiranda dauginės plaučių metastazės. Esant naviko diseminacijai pleuroje ir pleuritui, rekomenduojame videotoraskopijos metu įpūsti į pleuros ertmę talko. Prasminai žodžiai: plaučių metastazės, chirurginis gydymas, papildomasis gydymas, vėlyvieji gydymo rezultatai Results of surgical treatment for pulmonary metastases Algirdas Jackevičius, Saulius Cicėnas, Dainius Piščikas Background / objective Treatment of metastases in lung from other organs is serious clinic problem. There are controversies about the surgical treatment of metastases in lung. In this paper we have taken our data about the surgical treatment of metastases in lung from other organs. Methods of treatment of metastases in lung and the follow-up results are presented. Patients and methods In the Thoracic Clinic of Institute of Oncology Vilnius University in the course of 1998–2002 168 patient (pts) with metastases in lung from other tumors were treated surgically. There were 81 males and 87 females. Mean age of males was 59.5 years (range 23–83 years). Mean age of females was 55.1 years (range 23–77 years).The most common primary tumor in females was cancer of breast – 37 pts, from ovarian – 9, from uterus – 8, from renal cell – 8, from other lung – 5, from hepatobiliary – 3, from colon – 3, from rectal – 3, from sarcoma of soft tissue – 3, melanoma – 2, from nasopharynx, thyroid, stomach, osteosarcoma – 1. In males: renal cell – 17 cases, from other lung – 13, from colorectal – 9, from testis – 9, from larynx – 6, from thyroid – 5, from osteosarcoma – 5, from prostate – 5, from sarcoma of soft tissue – 3, stomach – 2, adrenal – 2, from bladder, melanoma, oral cavity – 1. Surgical treatment: in 5 cases – pneumonectomy, 31 – lobectomy , 40 – segmentectomy, 14 – wedge resection, 11 – metastasectomy, 26 – thoracotomy, 38 – videothoracoscopy with insufflation of talc. Results 40 pts died from the progression of disease, median survival – 7.5 month (range 1–27 month). The follow-up results were better after the radical operations: median survival of pts after lobectomy was 12.4 months, after segmentectomy – 10.2 months, after wedge resection – 10.5 months. In the cases of pleural dissemination the pts lived 3,4 months. Conclusions Surgical treatment of solitary metastases in lung is favourable for life prolongation of patients. The best follow-up results were received after surgical treatment of solitary metastases in lung in pts with colorectal and renal cell carcinoma. The follow-up results are unsatisfactory of pts with ovarian, breast carcinoma and melanoma. In many cases of this carcinoma was pleural dissemination with metastases. Insufflation of talc is recommended to patients with pleural effusion. Keywords: metastases in lung from other tumors, primary tumors from other organs, surgical treatment, adjuvant therapy, follow-up results
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Leung, P., E. Lester, A. G. Doumouras, A. G. Doumouras, F. Saleh, S. Bennett, C. Fulton, et al. "2015 Canadian Surgery Forum02 The usefulness and costs of routine contrast studies after laparoscopic sleeve gastrectomy for detecting staple line leaks03 The association of change in body mass index and health-related quality of life in severely obese patients04 Inpatient cost of bariatric surgery within a regionalized centre of excellence system05 Regional variations in the public delivery of bariatric surgery: an evaluation of the centre of excellence model06 The effect of distance on short-term outcomes after bariatric surgery07 The role of preoperative upper endoscopy in bariatric surgery: a systematic review08 Outcomes of a dedicated bariatric revision surgery clinic10 Quality of follow-up: a systematic review of the research in bariatric surgery14 Bariatric surgery improves weight loss and cardiovascular disease compared with medical management alone: an Alberta multi-institutional early outcomes study16 Diabetic control after laparoscopic gastric bypass and sleeve gastrectomy: a short-term prospective study17 Knowledge and perception of bariatric surgery among primary care physicians: a survey of family doctors in Ontario19 Is early discharge of patients post laparoscopic sleeve gastrectomy safe?22 A comparison of outcomes between bariatric centres of excellence within Ontario02 Closure methods for laparotomy incisions: a cochrane review03 Closing the audit cycle: Are we consenting correctly now?05 Regional variation in the use of surgery in Ontario06 Quitting general surgery residency: attitudes and factors in Canada07 Nipple-sparing mastectomy: utility of intraoperative frozen section analysis of retroareolar tissue08 Withdrawn09 Reliable assessment of operative performance10 Video assessment as a method of assessing surgical competence: the difference in video-rating skills after 4 years of residency11 Burnout among academic surgeons13 Increased health services use by severely obese patients undergoing emergency surgery: a retrospective cohort study14 Novel models for advanced laparoscopic suturing: taking it to the next level16 Pectoral nerve block in breast and axillary surgery17 Predictors for positive resection margins in gastric adenocarcinoma: a population-based analysis18 Predictors of malignancy in thyroid nodules19 Safety and efficacy of POEM for treatment of achalasia: a systematic review of the literature20 Informed consent for surgery21 Meconium ileus: 20 years of experience22 Paraesophageal hernia repair in the elderly: outcomes in a 10-year retrospective study23 The changing face of breast cancer: younger age and aggressive disease in Filipino Canadians24 A systematic review of intraoperative blood loss estimation methods for major noncardiac surgery: a 50-year perspective25 The AVATAR trial: applying vacuum to accomplish reduced wound infections in laparoscopic pediatric surgery27 Indications for use of damage control surgery in civilian trauma patients: a content analysis and expert appropriateness rating study28 Indications for use of thoracic, abdominal, pelvic, and vascular damage control interventions in trauma patients: a content analysis and expert appropriateness rating study29 The impact of health care contact and invasive procedures on Staphylococcus aureus bacteremia: a 5-year retrospective cohort study30 Acute care surgery — positive impact on gallstone pancreatitis31 Safety and efficacy of a step-up approach to management of severe, refractory Clostridium difficile infection32 Clinical and operative outcome of patients with acute cholecystitis who are treated initially with image-guided cholecystostomy34 Assessment of preoperative carbohydrate loading and blood glucose concentration in patients with diabetes35 Impact of pre-emptive lidocaine infiltration at trocar sites (PLITS) and intraoperative ketorolac administration on postoperative pain and narcotics consumption after endocholecystectomy: a randomized-controlled trial36 Expert intraoperative judgment and decision-making: defining the cognitive competencies for safe laparoscopic cholecystectomy37 Teaching clinical anatomy to postgraduate surgical trainees38 Investigating the role of TNFR1 in gastric adenocarcinoma peritoneal metastasis39 Selective outcome reporting and publication biases in surgical randomized controlled trials40 Definitive percutaneous management of symptomatic cholelithiasis41 Peer-based coaching: an innovative method to teach faculty an advanced laparoscopic technique42 Improving teaching and learning in the operating room: Does the surgical procedure feedback rubric support learning?43 Withdrawn44 Mislabelling study designs as case–control in surgical literature45 Measured resting energy expenditure in patients with open abdomens: preliminary data of a prospective pilot study46 Open abdomen management and primary abdominal closure in a surgical abdominal sepsis cohort: a retrospective review47 The effect of early mobilization protocols on postoperative outcomes following abdominal and thoracic surgery: a systematic review49 Program directors and trainees attitudes toward the introduction of multi-source feedback as part of surgical residents’ formative assessment process at the University of Calgary: a qualitative study50 Outcomes associated with alternate blunt cerebrovascular injury detection strategies in major trauma patients: a systematic review and meta-analysis51 Assessing the effect of preoperative nutrition on the surgical recovery of elderly patients53 Why is the percentage of medical students selecting a general surgery career different between Canadian medical schools?54 Colorectal cancer patient perspectives of preoperative repeat endoscopy: a qualitative study55 Staphylococcus aureus bacteremia in a pediatric population: a retrospective study in a tertiary-care referral centre56 The impact of postoperative complications on the recovery of elderly surgical patients57 Withdrawn58 The economics of recovery after pancreatic surgery: detailed cost minimization analysis of a postoperative clinical pathway for patients undergoing pancreaticoduodenectomy59 2015 CJS Editor’s Choice Award Recipient: Achalasia-specific quality of life after pneumatic dilation and laparoscopic Heller myotomy with partial fundoplication: a randomized clinical trial60 NSAID use is associated with an increased risk of anastomotic leak after colorectal surgery: results of a frequentist and Bayesian meta-analysis61 Miracles for babies with abnormal lungs: the story of miR-10a and lung development62 Investigating hospital readmissions and unplanned ED visits following general surgical procedures at a tertiary care centre63 Remote FLS testing: ready for prime time64 Contrast blush (CB) significance on computed tomography (CT) and correlation with noninterventional management (NIM) failure for blunt splenic injury (BSI) in children65 Bridging the gap on the surgical ward: enhancing resident–nurse communication through a CUSP pilot project66 A prospective interim analysis of microbiological gene expression profile of Staphyloccocus aureus bacteremia and its clinical implications67 Outcomes of selective nonoperative management of civilian abdominal gunshot wounds: a systematic review and meta-analysis68 Does rater training improve the reliability of surgical skill assessments? A randomized control trial69 Parallel or divergent? The evolution of emergency general surgery service delivery at 3 Canadian teaching hospitals70 Surgeon satisfaction in the era of dedicated emergency general surgery services: a multicentre study74 Withdrawn76 Timing of cholecystectomy after gallstone pancreatitis: Are we meeting the standards?77 Management of traumatic occult hemothorax, a survey of trauma providers in Canada78 Withdrawn01 Extent of lymph node involvement after esophagectomy with extended lymphadenectomy for esophageal adenocarcinoma predicts recurrence: a large North American cohort study02 A randomized comparison of electronic versus handwritten daily notes in thoracic surgery03 Is tissue still the issue? Lobectomy for suspected lung nodules without preoperative or intraoperative confirmation of malignancy04 Incidence of pulmonary embolism and deep vein thrombosis following major lung resection: a prospective multicentre incidence study05 Venous thromboembolism (VTE) prophylaxis in thoracic surgery: a Canadian national delphi consensus survey06 Preoperative chemoradiation therapy v. chemotherapy in patients undergoing modified en bloc esophagectomy for locally advanced esohageal adenocarcinoma: Does radiation add value?07 Comparative outcomes following tracheal resection for benign versus malignant conditions08 Combined clinical staging for resectable lung cancer: clinicopathological correlations and the role of brain MRI10 A retrospective cohort evaluation of non–small cell lung cancer recurrence detection11 Health-related quality of life measure distinguishes between low and high T stages in esophageal cancer12 Transition from multiport to single-port anatomic lung resection is feasible13 Survival rates in patients with N3 esophageal adenocarcinoma treated with neoadjuvant chemotherapy and esophagectomy with en-bloc lymphadenectomy14 Impact of a dedicated outpatient clinic on the management of malignant pleural effusions16 Has the quality of reporting of randomized controlled trials in thoracic surgery improved?17 Clinical features distinguishing malignant from benign esophageal diagnoses in patients referred to an esophageal diagnostic assessment program18 Concordance with invasive mediastinal staging guidelines19 Current lung-protective ventilation strategies may not be protective during one-lung ventilation surgery20 National practice variation in pneumonectomy perioperative care — results from a survey of the Canadian Association of Thoracic Surgeons21 Outcomes after multimodal treatment of esophagogastric neuroendocrine carcinoma: Is there a role for resection?22 Clinical results of treatment for isolated axillary and plantar hyperhidrosis: a single centre experience23 The role of pneumonectomy after neoadjuvant chemotherapy for N2 non–small cell lung cancer24 Time delays in the management of non–small cell lung cancer: a comparison between high-volume designated and low-volume community hospitals25 Regionalization and outcomes of lung cancer surgery in Ontario, Canada26 Robotic pulmonary resection for lung cancer: the first Canadian series01 The effect of early postoperative nonsteroidal anti-inflammatory drugs on pancreatic fistula following pancreaticoduodenectomy02 Laparoscopic ultrasound still has a role in the staging of pancreatic cancer: a systematic review of the literature03 Impact of portal vein embolization on morbidity and mortality of major liver resection in patients with colorectal metastases: experience of a small single tertiary care centre04 A decision model and cost analysis of intraoperative cell salvage during hepatic resection05 The impact of portal pedicle clamping on survival from colorectal liver metastases in the contemporary era of liver resection: a matched cohort study06 Clinical and pathological features of intraductal papillary neoplasms of the biliary tract and gallbladder07 International practice patterns among ALPPS surgeons: Do we need a consensus?08 Omental flaps to protect pancreaticojejunostomy in pancreatoduodenectomy11 Preoperative diagnostic angiogram and endovascular aortic stent placement for appleby resection candidates: a novel surgical technique in the management of locally advanced pancreatic cancer12 Recurrence following initial hepatectomy for colorectal liver metastases: a multi-institutional analysis of patterns, prognostic factors and impact on survival13 The influence of the multidisciplinary cancer conference era on the management of colorectal liver metastases14 Monosegment ALPPS hepatectomy: extending resectability by rapid hypertrophy15 How does simultaneous resection of colorectal liver metastases impact chemotherapy administration?16 Preoperative liver volumetry for surgical planning: a systematic review and evaluation of current modalities17 Surgical planning of hepatic metastasectomy using radiologist performed intraoperative ultrasound21 Surgical resection and perioperative chemotherapy for colorectal cancer liver metastases: a population-based study22 Management and outcome of colorectal cancer (CRC) liver metastases in the elderly: a population-based study23 Outcomes following repeat hepatic resection for recurrent metastatic colorectal cancer: a population-based study24 A clinical pathway after pancreaticoduodenectomy standardizes postoperative care and may decrease postoperative complications25 Significance of regional lymph node involvement in patients undergoing liver resection and lymphadenectomy for colorectal cancer metastases26 NSAID use and risk of postoperative pancreatic fistulas following pancreaticoduodenectomy: a retrospective cohort study27 Minimally invasive HPB surgery in Canada: What are we doing and do we want to do more?28 2015 CJS Editor’s Choice Award Recipient: Predictors of actual survival in resected pancreatic adenocarcinoma: a population-level analysis29 Predictors of receipt of adjuvant therapy following pancreatic adenocarcinoma resection: a population-based analysis30 Effect of surgical wait time on oncological outcomes in periampullary cancer31 Does surgical assist expertise affect resectability in periampullary malignancies?32 The impact of tranexamic acid on fibrinolytic activity during major liver resection33 Colorectal cancer with synchronous hepatic metastases: a national survey of opinions on treatment sequencing and multidisciplinary cooperation34 Outcomes associated with a matched series of patients undergoing sequential resections of colorectal cancer and hepatic metastases compared with synchronous surgical therapy of the primary and hepatic metastases35 The impact of anesthetic inhalational agent on short-term outcomes after liver resection38 The impact of perioperative blood transfusions on posthepatectomy short-term outcomes: an analysis from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP)39 Associations between pancreatic cancer quality indicators and outcomes in Nova Scotia40 Developing a national quality agenda in hepato-pancreato-biliary surgery: key priority areas for study02 Withdrawn03 Histological features and clinical implications of polypropylene degradation04 A rare case of primary hernia of the perineum05 Migration of polypropylene mesh in the development of late complications06 Laparoscopic hernia repair — Has this procedure run its course?07 Mesh materials used for hernia repair: Why do they shrink?08 The role of pure tissue repairs in a tailored concept for inguinal hernia repair09 Recurrent inguinal hernias a persistent problem in hernia surgery: analysis of 14 640 recurrent cases in the German hernia database, Herniamed10 Open circular intra-abdominal ventral herniorrhaphy: a new technique in ventral hernia repair01 Misrepresentation or “spin” is common in robotic colorectal surgical studies02 Postoperative pelvic sepsis rates following complete pathologic response to neoadjuvant therapy in rectal cancer03 Understanding the complexities of shared decision-making in cancer: a qualitative study of the perspectives of patients undergoing colorectal surgery04 Impact of hospital volume on quality indices for rectal cancer surgery in British Columbia, Canada07 The effect of laparoscopy on inpatient cost after elective colectomy for colon cancer08 Predictors of variation in neighbourhood access to laparoscopic colectomy for colon cancer09 Predictors of 30-day readmission after elective colectomy for colon cancer10 Neutrophil-to-lymphocyte ratio predicts major perioperative complications in patients with colorectal cancer12 Sessile serrated adenoma (SSA) detection-predictive factors13 Diverticular abscess managed with long-term definitive nonoperative intent is safe14 Long-term outcomes of conservative management following successful nonoperative treatment of acute diverticulitis with abscess: a systematic review15 Incidence of ischemic colitis after abdominal aortic aneurysm repair: results from the national surgical quality improvement program database16 Sigmoid colectomy for acute diverticulitis in immunosuppressed v. immunocompetent patients: outcomes from the ACS-NSQIP database17 A cross-sectional survey of health and quality of life of patients awaiting colorectal surgery in Canada19 Self-expanding metal stents versus emergent surgery in acute malignant large bowel obstruction20 Combined laparoscopic and TAMIS LAR in a morbidly obese patient after open right hepatectomy21 Safety and feasibility of laparoscopic rectal cancer resection in morbidly obese patients22 Factors associated with morbidity following sacral neurostimulation for fecal incontinence: beware of the high risk groups23 Hyperglycemia increases surgical site infections following colorectal resections for malignancy in a standardized patient cohort24 Implementing an enhanced recovery program after colorectal surgery in elderly patients: Is it feasible?25 From laparoscopic-assisted to total laparoscopic right colectomy with intracorporeal anastomosis: Is the shift in technique justified?26 Surgical site infection rates following implementation of a “colorectal closure bundle” in elective colorectal surgeries27 Quality of life and anorectal function of rectal cancer patients in long-term recovery28 Combined laparoscopic/transanal endoscopic microsurgery approach to radical resection for rectal tumours29 Transanal endoscopic microsurgery resection of rectal neuroendocrine tumours: a single centre Canadian experience30 Abdominoperineal reconstruction with a myocutaneous flap32 Comparison of robotic and laparoscopic colorectal surgery with respect to 30-day perioperative morbidity33 Definitive management of fistula-in-ano using draining setons35 Oncologic outcomes following complete pathologic response to neoadjuvant therapy in rectal cancer36 Laparoscopic total mesorectal excision in obese patients with rectal cancer: What is the oncological impact?38 Improving the enhanced recovery programs in laparoscopic colectomy: liposomal bupivacaine may not be the answer39 Fistulae related to colonic diverticular disease: a single institution experience41 Laparoscopic colectomy for malignancy provides similar pathologic outcomes and improved survival outcomes compared with open approaches42 MRI utilization and completeness of reporting in rectal cancer: a population-based study43 Supporting quality assurance initiatives for rectal cancer: Is the CAP protocol enough?44 Accuracy and predictive ability of preoperative MRI for rectal adenocarcinoma: room for improvement47 A population-based study of colorectal cancer in patients ≤ 40: Does the extent of resection affect outcomes?48 Transanal minimally invasive surgery (TAMIS) for rectal neoplasms01 The impact of blood transfusion on perioperative outcomes following resection of gastric cancer: an analysis of the ACS-NSQIP02 Association of wait time to surgical management with overall survival in Ontarians with melanoma04 General surgeons’ attitudes toward breast reconstruction in the province of Quebec06 Neoadjuvant chemotherapy for breast cancer: Is practice changing? A population-based review of current surgical trends07 Robotic versus laparoscopic versus open gastrectomy for gastric adenocarcinoma15 Influence of preoperative MRI on the surgical management of breast cancer patients17 Adverse events related to lymph node dissection for cutaneous melanoma: a systematic review and meta-analysis19 Regional variations in survival, case volume and intraoperative margin assessment in resected gastric cancer20 Comparison of clinical and economic outcomes between robotic, laparoscopic and open rectal cancer surgery: early experience at a tertiary care centre21 Outcomes and clinicopathologic features of patients with Angiosarcoma of the breast23 Postmastectomy radiation: Should subtype factor in to the decision?24 Omission of axillary staging in elderly patients with early stage breast cancer impacts regional control but not survival: a systematic review and meta-analysis25 Objective pathological assessment of CRCLM by MALDI26 Identification of predictive tumour markers in breast cancer tissue — a pilot study research plan27 Reframing women’s risk: counselling on contralateral prophylactic mastectomy in non–high risk women with early breast cancer28 Withdrawn30 Comparison of different methods of immediate breast reconstructions for breast cancer patients: Is “single stage” really better?32 Is lymph node ratio a more accurate prognostic factor in stage III colon cancer than standard nodal staging?33 Costs associated with reoperation in the setting of attempted breast-conserving surgery: a decision analysis34 Polo-like kinase 4 (Plk4) activates Cdc42, stimulates cell invasion and enhances cancer progression in vivo35 Negative predictive value of preoperative abdominal CT in determining gastric cancer resectability on a population level36 2015 CJS Editor’s Choice Award Recipient: (18)F-fluoroazomycin arabinoside positron emission tomography (FAZA-PET) imaging predicts response to chemoradiation and evofosfamide (TH-302) in a preclinical xenograft model of rectal cancer37 Impact of a regional guideline on the surgical treatment of the axilla in patients with breast cancer: a population-based study39 Recent trends in port-site metastasis following laparoscopic resection of gallbladder cancer: a systematic review40 Real-time electromagnetic navigation for breast tumour resection: pilot study on palpable tumours41 Neoadjuvant imatinib for primary gastrointestinal stromal tumour (GIST): mutational status and timing of resection42 Adherence to osteoporosis screening guidelines in seniors with breast cancer treated with anti-estrogen therapy: a population-based study43 Automated robot interventions for enhanced clinical outcomes in breast biopsy44 Preoperative pregabalin or gabapentin for postoperative acute and chronic pain among patients undergoing breast cancer surgery: a systematic review and meta-analysis of randomized controlled trials46 Uptake and impact of synoptic reporting on breast cancer operative reports in a community care setting47 Withdrawn." Canadian Journal of Surgery 58, no. 4 Suppl 2 (August 2015): S169—S238. http://dx.doi.org/10.1503/cjs.008615.

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Inoue, Manabu, Masaya Yotsukura, Yukihiro Yoshida, Kazuo Nakagawa, and Shun-ichi Watanabe. "A case of cardiac herniation after right pneumonectomy." Asian Cardiovascular and Thoracic Annals, May 3, 2022, 021849232210978. http://dx.doi.org/10.1177/02184923221097841.

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A cardiac herniation is a rare but life-threatening complication after pneumonectomy. In most cases, it manifests suddenly as severe hypotension and cardiac arrest within 24 h of pneumonectomy. Here, we report a case of sudden-onset cardiac herniation after right pneumonectomy during which the pericardium was incised. The diagnosis was made immediately based on chest X-ray and electrocardiogram findings, and the heart was repositioned by repeat thoracotomy as an urgent life-saving measure. Surgeons should be aware of this potential surgical complication as well as its clinical manifestations, given that delayed diagnosis would directly lead to a fatal outcome.
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Ikeda, Masaki, Hideki Motoyama, Makoto Sonobe, and Hiroshi Date. "Single-lobe transplantation with contralateral pneumonectomy: Long-term survival." Asian Cardiovascular and Thoracic Annals, September 13, 2021, 021849232110443. http://dx.doi.org/10.1177/02184923211044398.

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We report two cases of long-term survival after single living-donor lobar lung transplantation with contralateral pneumonectomy. An 8-year-old female with pulmonary graft-versus-host disease after cord-blood transplantation underwent single living-donor lobar lung transplantation with simultaneous contralateral pneumonectomy due to an oversized graft. She has been performing daily life activities for ≥11 years with limited physical development. A 41-year-old female with short stature underwent single living-donor lobar lung transplantation due to pulmonary graft-versus-host disease after peripheral blood stem cell transplantation. Contralateral pneumonectomy was required 7 years following living-donor lobar lung transplantation due to pneumonia in the native lung. Eleven years after living-donor lobar lung transplantation, she is able to perform daily life activities.
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He, Gengxu, Tong Yao, Lei Zhao, Hong Geng, Qiang Ji, Kun Zuo, Yuanzhi Luo, and Kai Zhou. "Cardiac herniation presenting as superior vena cava obstruction syndrome after intrapericardial pnemonectomy for locally advanced lung cancer---case report." Journal of Cardiothoracic Surgery 16, no. 1 (March 31, 2021). http://dx.doi.org/10.1186/s13019-021-01439-5.

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Abstract Introduction Cardiac herniation is a rare complication after pulmonary surgery, and there are only a few reports about it. We now report a case of cardiac herniation presenting as superior vena cava obstruction after pneumonectomy. Case presentation A-52-years old woman diagnosed right pulmonary squamous cell carcinoma was carried out right pneumonectomy, the pulmonary artery and right superior pulmonary vein were dissected and ligated intrapericardial. The patient developed tachycardia arrhythmias, hypotension, followed by loss of consciousness at about 18 h after operation. After resuscitation, the patient was conscious but developed cyanosis of the superior vena cava drainage area, uropenia, and hypotension (80/30 mmHg). Bedside-echocardiography showed that the SVC was obstructed due to thrombus formation. Chest radiography a shift of the heart into right hemithorax. Rethoracotomy was performed and the herniated heart was replaced into the pericardium, and the pericardium was repaired with Gore Tex patch. The patient recovered smoothly after the second surgery. Conclusion Cardiac herniation is a rare and fatally complication after thoracic surgery, and the prompt recognition with timely intervention is life-saving. Cardiac herniation is a rare but fatal complication of pneumonectomy. The increasing frequency of surgical resection for locally advanced thoracic carcinoma has led to a renewed emphasis regarding early diagnosis and treatment for cardiac herniation. Here we discuss a case of cardiac herniation presented with acute superior vena cava obstruction syndrome and hemodynamic instability after intrapericradial right pneumonectomy.
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32

Burel, Julien, Mathias El Ayoubi, Jean-Marc Baste, Matthieu Garnier, François Montagne, Jean-Nicolas Dacher, and Matthieu Demeyere. "Surgery for lung cancer: postoperative changes and complications—what the Radiologist needs to know." Insights into Imaging 12, no. 1 (August 12, 2021). http://dx.doi.org/10.1186/s13244-021-01047-w.

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AbstractImaging findings after thoracic surgery can be misleading. Knowledge of the normal post-operative anatomy helps the radiologist to recognise life-threatening complications and conversely not to wrongly evoke a complication in cases of trivial post-operative abnormalities. In this educational article, we reviewed the expected patterns after thoracic surgery including sublobar resection, lobectomy, pneumonectomy and related techniques. Imaging aspects of frequent and less common complications and their typical imaging features are then presented.
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33

Lauk, Olivia, Miriam Patella, Thomas Neuer, Ilhan Inci, Walter Weder, and Isabelle Opitz. "Quality of Life Is Not Deteriorated After Extrapleural Pneumonectomy vs. (Extended) Pleurectomy/Decortication in Patients With Malignant Pleural Mesothelioma." Frontiers in Surgery 8 (December 8, 2021). http://dx.doi.org/10.3389/fsurg.2021.766033.

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Background: Extrapleural pneumonectomy (EPP) for malignant pleural mesothelioma (MPM) is highly abandoned due to high morbidity and mortality rates and impaired quality of life (QoL). However, there are still rare indications for this intervention. The aim of this longitudinal prospective study was to monitor QoL and lung function in patients undergoing EPP and compare the outcomes with extended pleurectomy/decortication [(E)PD].Methods: Between June 2013 and June 2017, 42 patients underwent induction chemotherapy followed by either EPP (n = 7) or (E)PD (n = 35). All patients filled out the EORTC QLC-C15-PAL, –LC13, and SF-36 self-rating questionnaires pre-operatively, 6 weeks and 4 months after the operation. Additionally, lung function was measured pre-operatively and 4 months post-operatively.Results: We observed no significant differences in all QoL categories (general global health, pain, and dyspnea) between both surgical procedures, over the whole observation period. Moreover, a general tendency toward restoration of the pre-operative QoL status was documented at 4 months after the both operations. Forced expiratory volume in 1 s (FEV1) showed a significant decrease after surgery in both the groups [EPP group p = 0.06 and (E)PD group p &lt; 0.001]; also, the forced volume vital capacity (FVC) significantly decreased (EPP group p = 0.046 P/D group &lt;0.001). Diffusion capacity did not show significant changes.Conclusion: According to these results, QoL is no longer severely impaired after EPP compared with EPD, and therefore should not be used as an argument against EPP in principle. However, indication has to be carefully evaluated for each patient.
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Hino, Haruaki, Takahiro Utsumi, Natsumi Maru, Hiroshi Matsui, Yohei Taniguchi, Tomohito Saito, Koji Tsuta, and Tomohiro Murakawa. "Results of emergency salvage lung resection after chemo- and/or radiotherapy among patients with lung cancer." Interactive CardioVascular and Thoracic Surgery, March 7, 2022. http://dx.doi.org/10.1093/icvts/ivac043.

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Abstract OBJECTIVES This study aimed to elucidate the outcomes of emergency salvage surgery following life-threatening events (serious haemorrhage and/or infections) among patients with lung cancer who had undergone chemo- and/or radiotherapy. Materials and Methods We analysed the data of patient from 2015 to 2020, retrospectively. The clinical characteristics, including preoperative treatment, perioperative outcomes and survival time, were analysed. RESULTS Of the 862 patients who underwent primary lung cancer surgeries, 10 (1.2%) underwent emergency surgeries. The preoperative clinical characteristics were: median age, 63.7 years [interquartile range (IQR) 55–70.5]; sex (male/female), 9/1; clinical staging before initial treatment (I/II/III/IV), 1/1/3/5; initial treatment (chemoradiotherapy/chemotherapy/proton beam therapy), 5/4/1; and indications for emergency surgery (lung abscess/lung abscess with haemoptysis/haemoptysis/empyema), 5/3/1/1. The selected procedures and results were as follows: lobectomy/bilobectomy/pneumonectomy, 8/1/1 (all open thoracotomies); median operation time, 191.0 min (IQR 151–279); median blood loss, 1071.5 ml (IQR 540–1691.5); postoperative severe complications, 3 (30%); hospital mortality, none; median postoperative hospital stay, 37 days (12–125); control of infection and/or haemoptysis, all the cases; final outcome (alive/dead), 3/7 (all the cancer deaths); median postoperative survival, 9.4 months (IQR 4.3–20.4); and median survival from initial treatment, 19.4 months (IQR 8.0–66.9). CONCLUSIONS Emergency salvage lung resection is a technically challenging procedure; however, the results were feasible and acceptable when the surgical indication, procedure and optimal timing were considered carefully by a multidisciplinary team. Although the aim was palliation, some patients who received additional chemotherapy afterwards and, thus, had additional survival time.
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Qadri, Syed S. A., Alex Cale, Mahmoud Loubani, Mubarak A. Chaudhry, and Michael E. Cowen. "WITHDRAWN: Is there life after the Mesothelioma and Radical Surgery trial? Does extrapleural pneumonectomy still have a role in the management of pleural mesothelioma? A 13-year, single-center experience." Journal of Thoracic and Cardiovascular Surgery, January 2014. http://dx.doi.org/10.1016/j.jtcvs.2014.01.007.

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36

Grimm, Lucie M., Esther Humann-Ziehank, Norman Zinne, Patrick Zardo, and Martin Ganter. "Analysis of pH and electrolytes in blood and ruminal fluid, including kidney function tests, in sheep undergoing long-term surgical procedures." Acta Veterinaria Scandinavica 63, no. 1 (November 14, 2021). http://dx.doi.org/10.1186/s13028-021-00611-0.

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Abstract Background The physiology of sheep as small ruminants is remarkably different from monogastric animals especially regarding the forestomach system. Using sheep for surgical procedures during scientific research thereby presents an exceptional setting for the anaesthetist. Long-term anaesthesia generally demands deprivation of food to reduce the risk of bloat in sheep. This might influence the energy and electrolyte balance. In horses and companion animals, close monitoring of mean arterial blood pressure, capnography and blood gas analysis are common procedures during long-term surgery. However, few data are available on reference ranges for blood gas in sheep and these cover only short periods of anaesthesia. To the authors’ knowledge, there is no study available that includes the monitoring of electrolytes and pH in ruminal fluid and kidney function tests in sheep undergoing long term anaesthesia. Thereby, the aim of the present study was to gather data on blood parameters, and data on ruminal fluid and kidney function during long-term anaesthesia in sheep. Data were obtained from eight sheep undergoing the invasive surgical procedure of left pneumonectomy and auto-transplantation or isolated left lung perfusion. After a 19-h fasting period, the animals were administered xylazine and ketamine and then intubated and maintained in general anaesthesia under artificial ventilation using isoflurane in oxygen. Blood samples were evaluated during 9 h of anaesthesia; ruminal fluid and kidney function tests were evaluated during 7 h of anaesthesia. Results Blood parameters such as electrolytes and partial pressure of carbon dioxide revealed few changes, yet blood glucose decreased and beta-hydroxybutyric acid increased significantly. All animals showed an elevated arterial pH and bicarbonate concentration despite artificial ventilation. In ruminal fluid, the pH significantly decreased and no significant changes in electrolytes occurred. Kidney function tests revealed no significant changes in any of the animals. However, fractional excretion of water and phosphate was slightly increased. One animal showed severe complications due to hypokalaemia. Conclusion Invasive surgery under long-term anaesthesia in sheep is possible without great imbalances of arterial pH and electrolytes. Nevertheless, potassium concentrations should be monitored carefully, as a deficiency can lead to life-threatening complications. The operated sheep tended not to develop metabolic acidosis and the mean kidney function could be maintained within the physiological range throughout anaesthesia. However, slight elevations in renal fractional water and phosphate excretion could suggest an early tubular reabsorption dysfunction. In ruminal fluid, acidification occurred, though no significant changes were observed in l- and d-lactate levels or in electrolyte concentrations. To our knowledge, the role of the rumen in storing fluids and balancing electrolytes in the blood has not yet been documented during anaesthesia. However, the importance of the rumen for fluid equilibrium in sheep indicates the necessity for routine monitoring and further research.
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