Academic literature on the topic 'Lewis c'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Lewis c.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Lewis c"

1

Haack, Susan. "C. I. Lewis." Royal Institute of Philosophy Supplement 19 (March 1985): 215–38. http://dx.doi.org/10.1017/s1358246100004604.

Full text
Abstract:
Lewis, according to Kuklick, was ‘a private person’, of ‘unsparing honesty and … utter dedication to the rational pursuit of truth’. He was, Kuklick continues, ‘equally uncompromising in what he expected of his readers, and as a result wrote for and lectured to a tiny group of scholars’. I hope that—since I occasionally find myself borrowing from him and frequently find myself arguing with him—I may count myself as one of the ‘tiny group of scholars’ for whom Lewis wrote. And perhaps, by arguing with him again here, I may persuade some of you of the enduring interest of his work.
APA, Harvard, Vancouver, ISO, and other styles
2

Reynolds, Barbara, Margaret Patterson Hannay, and Katharyn F. Crabbe. "C. S. Lewis." Modern Language Review 80, no. 4 (October 1985): 920. http://dx.doi.org/10.2307/3728988.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Haack, Susan. "C. I. Lewis." Royal Institute of Philosophy Supplement 19 (March 1985): 215–38. http://dx.doi.org/10.1017/s0957042x00004600.

Full text
Abstract:
Lewis, according to Kuklick, was ‘a private person’, of ‘unsparing honesty and … utter dedication to the rational pursuit of truth’. He was, Kuklick continues, ‘equally uncompromising in what he expected of his readers, and as a result wrote for and lectured to a tiny group of scholars’. I hope that—since I occasionally find myself borrowing from him and frequently find myself arguing with him—I may count myself as one of the ‘tiny group of scholars’ for whom Lewis wrote. And perhaps, by arguing with him again here, I may persuade some of you of the enduring interest of his work.
APA, Harvard, Vancouver, ISO, and other styles
4

Cantley, Lewis C. "Lewis C. Cantley." Current Biology 19, no. 14 (July 2009): R540—R541. http://dx.doi.org/10.1016/j.cub.2009.06.010.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Lewis, S. I. "Beatrice Lewis." BMJ 326, no. 7404 (June 26, 2003): 1462—c—1462. http://dx.doi.org/10.1136/bmj.326.7404.1462-c.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

FOWLER, ALASTAIR. "C. S. LEWIS, TRANSLATOR." Yale Review 101, no. 2 (March 12, 2013): 139–52. http://dx.doi.org/10.1111/yrev.12044.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Hooper, Walter. "Remembering C. S. Lewis." Chesterton Review 17, no. 3 (1991): 369–71. http://dx.doi.org/10.5840/chesterton1991173/4101.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

McGovern, Eugene. "C. S. Lewis Issue." Chesterton Review 18, no. 2 (1992): 320–21. http://dx.doi.org/10.5840/chesterton199218248.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Cory, Charlotte. "Illustrating C. S. Lewis." Chesterton Review 28, no. 1 (2002): 213–16. http://dx.doi.org/10.5840/chesterton2002281/239.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Fowler, Alastair. "C. S. Lewis: Supervisor." Yale Review 91, no. 4 (October 2003): 64–80. http://dx.doi.org/10.1111/0044-0124.00751.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Dissertations / Theses on the topic "Lewis c"

1

Rector, Ann Mansfield. "Gleams of Godlight in the trilogy a study of myth and doctrine in the science fiction of C.S. Lewis /." Instructions for remote access. Click here to access this electronic resource. Access available to Kutztown University faculty, staff, and students only, 1985. http://www.kutztown.edu/library/services/remote_access.asp.

Full text
Abstract:
Thesis (M.A.)--Kutztown University of Pennsylvania, 1985.
Source: Masters Abstracts International, Volume: 45-06, page: 2846. Typescript. Abstract precedes thesis as preliminary leaves [1-2]. Includes bibliographical references (leaves [103]-106).
APA, Harvard, Vancouver, ISO, and other styles
2

Uszynski, Edward T. "Past watchful dragons the postmodern apologetic of C.S. Lewis /." Online full text .pdf document, available to Fuller patrons only, 2001. http://www.tren.com.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Bresland, Ronald W. "C. S. Lewis and the Irish imagination." Thesis, University of Ulster, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414985.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

McClinch, Christopher C. "Reason, Imagination, and Universalism in C. S. Lewis." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/10111.

Full text
Abstract:
Though he is generally known as one of the key voices in conservative Christianity, this thesis demonstrates that C. S. Lewis was in fact far more liberal in his view of salvation than many would expect. Lewis argued for a universalist interpretation of salvation, in which the death of Christ opened up the possibility of salvation for all of humanity, not merely those people who could be identified as Christians. Lewis did believe that people could and did choose Hell over Heaven, however, and still saw evangelism as the duty of every Christian. All of Lewis's writings are in a sense evangelistic, and all attempt to effect the conversion of the reader in the same manner in which Lewis himself was first drawn to Christianity: by baptizing the imagination in the hope that the reason will follow.
Master of Arts
APA, Harvard, Vancouver, ISO, and other styles
5

Boutin, Hugo. "Effet de l'acide de Lewis sur l'activation C-H par des paires de Lewis frustrées." Master's thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/33711.

Full text
Abstract:
Le domaine de recherche principal du groupe Fontaine porte sur le développement de catalyseurs sans métaux de type paire de Lewis frustrée (FLP). La formation de dimères entraine une perte de réactivité en raison du coût énergétique du bris du dimère. L’ajout de groupements alkyles à l’acide de Lewis de FLPs du type 1-BH2-2-NR2-C6H4 permet d’augmenter l’encombrement stérique de la molécule ambiphile, et ainsi déstabiliser la formation de dimères. Ces molécules ambiphiles (1-BH2-2-NR2-C6H4) sont cependant instables et nécessitent d’être stabilisées par l’ajout d’une base de Lewis. La réactivité de ces adduits a pu être évalué pour la borylation catalytique du N-méthylpyrrole. La forme dimérique des molécules ambiphiles semble prévenir leur dégradation. La sensibilité des aminoboranes aux réactifs protiques est connue. L’étude de la réactivité entre les thiols et l’aminoborane [1-BH2-2-NMe2-C6H4]2 a mené à la découverte d’un catalyseur efficace pour la borylation des thiols. Les liaisons bore-soufre sont des réactifs utiles et sous-utilisés en synthèse organique. Leur utilité dans des réactions d’addition de Michael et de thioestérification est discutée. Il s’agit d’un bon exemple où l’utilisation d’un catalyseur sans métal permet de synthétiser un produit à valeur ajoutée.
The main interest of the Fontaine research group is in the development of metal-free catalysis with frustrated Lewis pairs (FLP). Dimer formation is known to cause loss of reactivity due to the energetic cost of dimer dissociation. By adding alkyl groups to the Lewis acid moiety of the 1-BH2-2-NR2-C6H4 type FLP can enhance the bulk of the abiphilic molecule, and thus disfavor the formation of the dimer. Those ambiphilic molecules (1-BH2-2-NR2-C6H4) are unstable and require the addition of a Lewis base in order to be isolated. The reactivity of these adducts towards catalytic borylation of N-methylpyrrole has been evaluated. The stability of the dimer seems to prevent degradation of such molecules. The sensitivity of aminoboranes towards protic reagents is known. The investigation of the reactivity of [1-BH2-2-NMe2-C6H4]2 with thiols lead to the discovery of a novel metal-free catalyst for the borylation of thiols. Boron-sulfur bonds are useful yet underutilised reagents. Their ability to undergo Michael addition with enones and thioestérification with esters is discussed. It is a good example of the synthesis of a value-added product made possible by the use of a metal-free catalyst.
APA, Harvard, Vancouver, ISO, and other styles
6

Gray, Nancy L. "The integrated and balanced spirituality of C. S. Lewis." Theological Research Exchange Network (TREN), 2007. http://www.tren.com/search.cfm?p090-0351.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Kingsmill, Patricia. "C.S. Lewis on metaphor : a study of Lewis in the light of modern theory." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23850.

Full text
Abstract:
Although C. S. Lewis was not a metaphor theorist, the issue of metaphor appears often enough in his writings for one to cull from them a general theoretical view. This thesis attempts to examine Lewis's thoughts on metaphor against the background of modern metaphor theory. Forty or fifty years ago such a study would have been less fruitful, for his views on metaphor so differed from contemporary theorists that their works offered no positive atmosphere in which to approach his work. Now, however, the general tenor of certain streams in metaphor theory has become more amenable to his views. Indeed, it appears that some key issues raised in modern metaphor theory exist in a seminal form in Lewis's writings. While Lewis cannot be put into any one school, modern theory offers the necessary tools with which to approach his discussions of the figure. This thesis, therefore, begins by briefly outlining the history of metaphor theory in so far as it relates to Lewis. The second chapter discusses his metaphysics, since he believed that his views on metaphor had metaphysical implications. The third and fourth chapters present Lewis's view of metaphor' process and function, as gleaned from his writings. Finally, the thesis concludes by relating Lewis's view back to his metaphysics.
APA, Harvard, Vancouver, ISO, and other styles
8

Fernandez, Irène. "Mythe et rationalisme dans l'oeuvre de C. S. Lewis." Paris 3, 1992. http://www.theses.fr/1993PA030014.

Full text
Abstract:
L'imagination est generalement consideree comme etrangere a la raison. Mais elle ne peut creer des recits merveilleux, des mythes, sans avoir un rapport a la realite, et elle en dit donc quelque chose, sous son mode propre. On veut montrer, en etudiant l'oeuvre de c. S. Lewis (1898-1963), comment cette idee est parfaitement coherente avec un rationalisme de fond, si l'on admet que la raison ne peut tout dire de l'experience humaine a cause de l'inevitable abstraction de sa demarche. Il y a ainsi, de ce point de vue, une verite possible des images, mais plus encore des recits mythiques qui les organisent. Il faut donc prendre au serieux le mythe, jusque sur le plan religieux. Ce n'est pas en faire a tout coup une allegorie, comme le montrent les oeuvres de fiction de lewis, qui ne sont nullement allegoriques. Il faut lire le mythe comme revelant des aspects permanents de l'experience humaine ou de la subjectivite, dans son intimite, dans son rapport au monde, dans son rapport a dieu. Ce dernier point est capital dans l'oeuvre de lewis, penseur radicalement chretien : dans son idee et sa pratique d'une approche imaginative et indirecte de l'absolu, on peut trouver comme les lineaments d'une theo-logie poetique
It is often said that imagination is quite alien to reason. But reason tries to understand reality, and so does imagination, especially mythopoeic imagination, whose marvellous stories cannot have nothing to do with the real world. That is the case that c. S. Lewis, a christian and a staunch rationalist, puts forward in and by his whole work. According to him, there is some truth in myth, and we need it to offset the abstract nature of our rational thinking, which falls short of reason as logos. Therefore we must take myth seriously, even from a religious point of view. That does not means that we must take it to be allegorical : myth is no allegory, as can be shown by studying lewis's own stories, which are not allegorical. Myths are based on our acquaintace with "the other world of the spirit", and must be understood as revealing permanent aspects of human experience or subjectivity, in relation to the universe and to god. The last point is most important in lewis's thought : he has sometimes been called a lay theologian, and his imaginative and oblique approach to ultimate reality proves to have given us the outlines of something like a poetic theo-logy
APA, Harvard, Vancouver, ISO, and other styles
9

Holthausen, Michael H., Tayseer Mahdi, Christoph Schlepphorst, Lindsay J. Hounjet, Jan J. Weigand, and Douglas W. Stephan. "Frustrated Lewis pair-mediated C–O or C–H bond activation of ethers." Royal Society of Chemistry, 2014. https://tud.qucosa.de/id/qucosa%3A35977.

Full text
Abstract:
Protocols for the FLP-mediated transformation of ethers are presented. Distinct reaction pathways involving either C–O or C–H bond activation occur depending on the application of oxophilic B(C6F5)3 or hydridophilic tritylium ions as the Lewis acid.
APA, Harvard, Vancouver, ISO, and other styles
10

Cao, Min. "Enantioselective Transformations Promoted by Cooperative Functions of an Achiral Lewis Acid and a Chiral Lewis Acid:." Thesis, Boston College, 2021. http://hdl.handle.net/2345/bc-ir:109203.

Full text
Abstract:
Thesis advisor: Masayuki Wasa
Thesis advisor: Amir H. Hoveyda
This dissertation describes the development of cooperative catalyst systems that contain an achiral Lewis acid and a chiral Lewis acid that may have overlapping functions but play their independent roles to promote enantioselective C–C bond formations. Chapter 1 provides a summary of recent advances made in the field of enantioselective cooperative catalysis that served as intellectual foundations for this dissertation research. As it will be discussed in the first chapter, key limitations of cooperative catalysis are: (1) undesirable catalyst deactivation which occurs due to acid/base complexation, (2) requirement for base sensitive pronucleophiles and acid sensitive electrophiles, and (3) poor reaction efficiency. In an effort to overcome these fundamental limitations, we have developed “frustrated” Lewis pair (FLP)-based catalyst systems that consist of potent and sterically encumbered Lewis acids used in pair with bulky N-containing Lewis bases. To demonstrate the potential of the novel FLP catalyst system, we describe our work involving the enantioselective Conia-ene-type cyclization (Chapter 2). In the subsequent chapter (Chapter 3), we discuss the application of the FLP catalysts for enantioselective β-amino C–H functionalization reactions
Thesis (PhD) — Boston College, 2021
Submitted to: Boston College. Graduate School of Arts and Sciences
Discipline: Chemistry
APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Lewis c"

1

Clark, David G., ed. C. S. Lewis. Oxford, UK: Blackwell Publishing Ltd, 2007. http://dx.doi.org/10.1002/9780470692387.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Abate, Michelle Ann, and Lance Weldy, eds. C. S. Lewis. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28497-6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Simply C. S. Lewis. Eastbourne: Kingsway, 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Lewis, C. S. The C. S. Lewis Bible. New York: HarperOne, 2010.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

C. S. Lewis: A biography. London: Flamingo, 1991.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

C. S. Lewis: A biography. London: Collins, 1990.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Lewis, C. S. Letters of C. S. Lewis. San Diego [Calif.]: Harcourt Brace, 1993.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

The C. S. Lewis handbook. Eastbourne, E. Sussex: Monarch, 1990.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Barratt, David. C. S. Lewis and his world. Basingstoke, Hants., Eng: Marshall Pickering, 1987.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Manlove, C. N. C. S. Lewis: His Literary Achievement. London: Palgrave Macmillan UK, 1987. http://dx.doi.org/10.1007/978-1-349-18909-0.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Lewis c"

1

Manlove, Colin. "C. S. Lewis." In Christian Fantasy, 237–61. London: Palgrave Macmillan UK, 1992. http://dx.doi.org/10.1007/978-1-349-12570-8_17.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Petzold, Dieter. "Lewis, C. S." In Kindlers Literatur Lexikon (KLL), 1. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_14172-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Weldy, Lance. "Introduction." In C. S. Lewis, 1–11. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28497-6_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Taylor, Jennifer. "“Beautiful Barbarians”: Anti-Racism in The Horse and His Boy and Other Chronicles of Narnia." In C. S. Lewis, 161–85. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28497-6_10.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Rodriguez, Susana. "Boy-Girls and Girl-Beasts: The Gender Paradox in C. S. Lewis’s The Chronicles of Narnia." In C. S. Lewis, 186–98. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28497-6_11.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Towns, Rachel. "“Turkish Delights and Sardines with Tea”: Food as a Framework for Exploring Nationalism, Gender, and Religion in The Lion, the Witch and the Wardrobe." In C. S. Lewis, 15–37. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28497-6_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Green, Melody. "Scapegoating and Collective Violence in The Lion, the Witch and the Wardrobe." In C. S. Lewis, 38–50. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28497-6_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Dorwick, Keith. "Moving Beyond “All That Rot”: Redeeming Education in The Chronicles of Narnia." In C. S. Lewis, 53–70. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28497-6_4.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Norris, Nanette. "War and the Liminal Space: Situating The Lion, the Witch and the Wardrobe in the Twentieth-Century Narrative of Trauma and Survival." In C. S. Lewis, 71–89. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28497-6_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Sommers, Joseph Michael. "C. S. Lewis’s Manifold Mythopoeics: Toward a Reconsideration of Eschatological Time in the Construction of The Chronicles of Narnia." In C. S. Lewis, 90–110. London: Macmillan Education UK, 2012. http://dx.doi.org/10.1007/978-1-137-28497-6_6.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Lewis c"

1

Lu, James. "C. S. Lewis and Ecocriticism." In Annual International Conference on Language, Literature & Linguistics (L3 2016). Global Science & Technology Forum ( GSTF ), 2016. http://dx.doi.org/10.5176/2251-3566_l316.73.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Shcherbinin, Vitaly, and Valery Konshin. "Lewis acid-mediated mono- and bis-addition of C-nucleophiles to 1,3-dioxolan-4-ones." In The 22nd International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2018. http://dx.doi.org/10.3390/ecsoc-22-05657.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Herbell, Thomas P., and Andrew J. Eckel. "Ceramic Matrix Composites for Rocket Engine Turbine Applications." In ASME 1992 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1992. http://dx.doi.org/10.1115/92-gt-394.

Full text
Abstract:
A program to establish the potential for introducing fiber reinforced ceramic matrix composites (FRCMC) in future rocket engine turbopumps was instituted in 1987. A brief summary of the overall program (both contract and in-house research) is presented. Tests at NASA Lewis include thermal upshocks in a hydrogen/oxygen test rig capable of generating heating rates up to 2500 °C/sec. Post thermal upshock exposure evaluation includes the measurement of residual strength and failure analysis. Test results for monolithic ceramics and several FRCMC are presented. Hydrogen compatibility was assessed by isothermal exposure of monolithic ceramics in high temperature gaseous hydrogen plus water vapor.
APA, Harvard, Vancouver, ISO, and other styles
4

Zaretsky, Erwin V., and Robert E. deLaneuville. "MMC Life System Development (Phase I): A NASA/Pratt & Whitney Cooperative Program." In ASME 1993 Design Technical Conferences. American Society of Mechanical Engineers, 1993. http://dx.doi.org/10.1115/detc1993-0073.

Full text
Abstract:
Abstract Pratt & Whitney Aircraft and NASA Lewis Research Center studied a silicon-carbide-fiber-reinforced, titanium-metal-matrix (MMC) composite designated SiC(SCS-6)/Ti-15V-3Cr-3Al-3Sn. Fracture tests of three nominal 15.24-cm (6-in.) diameter SCS–6/Ti-15-3 rings at 427 °C (800 °F) and room temperature resulted in failure at internal pressures of 0.172 GPa (25 ksi) (average) and 0.235 GPa (34.1 ksi), respectively. Predictions of internal pressure to failure varied from 0.140 to 0.276 GPa (20.3 to 40.1 ksi) at 427 °C (800 °F). Nondestructive evaluation revealed that the rings’ MMC cores had varying density and were not uniformly distributed inside the monolithic casing. Analytical predictions of ring cyclic life at 0.154-GPa (22.4-ksi) internal pressure varied from 1000 to 15 000 cycles. No fatigue life data were obtained with the MMC rings for comparison with theory.
APA, Harvard, Vancouver, ISO, and other styles
5

Sonsalla, Tyler J., Leland Weiss, Arden Moore, Adarsh Radadia, Debbie Wood, and Davis Bailey. "Zinc Composites With Enhanced Thermal Conductivity for Use in Fused Deposition Modeling Systems." In ASME 2017 Heat Transfer Summer Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/ht2017-5062.

Full text
Abstract:
Waste heat is a major energy loss in manufacturing facilities. Thermally conductive polymer composite heat exchangers could be utilized in the ultralow temperature range (below 200° C) for waste heat recovery. Fused deposition modeling (FDM), also known as three-dimensional (3-D) printing, has become an increasingly popular technology and presents one approach to fabrication of these exchangers. The primary challenge to the use of FDM is the low-conductivity of the materials themselves. This paper presents a study of a new polymer-Zn composite designed for enhanced thermal conductivity for usage in FDM systems. Thermal properties were assessed in addition to basic printability. Filler volume percentages were varied to study the effects on material properties. Scanning electron microscope (SEM) images were taken of the 3-D printed test pieces to determine filler orientation and filler distribution. Lastly, experimentally obtained thermal conductivity values were compared to the theoretical thermal conductivity values predicted from the Lewis-Nielsen model.
APA, Harvard, Vancouver, ISO, and other styles
6

Reeve, E. B. "MODEL STUDIES OF NEUTRALIZATION OF THROMBIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643277.

Full text
Abstract:
A kinetic model, based on published studies of thrombin neutralization, is used to examine factors that limit spread of free thrombin in a simple plasma. It employs equations with presently available rate parameters which describe the courses of the major thrombin-binding reactions at 37°C in buffered saline solutions approximating plasma ultrafiltrate. Thrombin is bound reversibly by fibrinogen and fibrin-1 polymers as enzyme-substrate complexes (1) and by “fibrin” at a non-proteolyt ic site (2), and essentially irreversibly by antithrombins (3). These bindings reduce free thrombin levels and so limit spread of activity. The model equations with parameters from (1) and (3) show that thrombin neutralization by thrombin-substrate complexes is very brief and thrombin-antithrombin reactions are much too slow for early reduction of thrombin activity. However, parameters from (2) show that rapid reversible binding of thrombin by “fibrin” much reduces level of free thrombin and the level continues to fall as the thrombin is passed to the antithrombins. The model shows that a rapidly-acting antithrombin (e.g. heparin-ATIII) could reduce free thrombin fast enough to inhibit slower thrombin activations (e.g. of FXIII), and that a sufficient concentration of a reversible binder can govern the level of free thrombin. This suggests that a non-toxic reversible binder, with suitable Kd and half-life, would be valuable in treating thrombosis. Verification and extension of the model findings require better experimental definition of the parameters.(1) Lewis, S.D. et al. J. Biol. Chem. 260, 10192-10199, 1985.(2) Liu, C.Y. et al. J. Biol. Chem. 254, 10421-10425, 1979.(3) Jordan, R. et al. J. Biol. Chem. 254, 2902-2913, 1979. (Supported by grants from the Colorado Heart Foundation)
APA, Harvard, Vancouver, ISO, and other styles
7

Briones, Alejandro M., Robert Olding, Joshua P. Sykes, Brent A. Rankin, Kyle McDevitt, and Joshua S. Heyne. "Combustion Modeling Software Development, Verification and Validation." In ASME 2018 Power Conference collocated with the ASME 2018 12th International Conference on Energy Sustainability and the ASME 2018 Nuclear Forum. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/power2018-7433.

Full text
Abstract:
Historically, combustion modeling is important for many transportation- and ground-based applications. More recently, modeling has been offered as an early screening tool in the evaluation of a potential alternative aviation jet fuel. This combustion evaluation path would in theory be conducted by gas turbine Original Equipment Manufacturers (OEMs) on proprietary geometries and conditions. Ideally, OEMs would have access to the latest combustion theory models and would thus have the highest predictive confidence in their model predictions. Unfortunately, the latest combustion theory codes are not written for commercial purposes. This work identifies and develops a conduit for OEM usage of latest flamelet theory for use in the evaluation of alternative jet fuel combustion properties. A so-called “common format routine” (CFR) software with two low-dimensional manifold combustion models that can be used for laminar and turbulent applications is developed, which can be implemented by OEMs on proprietary hardware. The two models are the flamelet prolongation of the intrinsic low-dimensional manifold (FPI), used for premixed combustion, and the flamelet progress variable (FPV), utilized for nonpremixed combustion. The three branches of combustion are computed using a hybrid tool that combines homotopic flamelet calculations with scaling laws and the two- and one-point flamelet continuation methods in order to resolve bifurcations. The mixture fraction and progress variable definitions can be chosen to be any summation of atomic and species composition, respectively. Diffusivity coefficients can be computed using unity Lewis number, mixture-averaged and multicomponent species composition. The turbulence-chemistry interaction is tabulated a priori using Beta probability density function (PDF) for the mixture fraction and Beta or Dirac-delta PDF for the progress variable. Parallel computing is necessary for industrial quality tabulation. The tabulated table can be used for k-ε and k-ω RANS, SAS, DES, and LES simulations. The software can also interact with liquid spray and exchange mass between the liquid and gaseous phase. The software is verified against previous numerical simulations of canonical triple flames, piloted flames and single-cup combustor. The numerical results are validated against experimental measurements of temperature and species mass fractions. The CFR software advances Cantera 2.3. Hence, the software contains an inner layer of C++ code, an intermediate layer of Python wrappers, and an upper layer (GUI) of C# code. The pre-tabulated chemistry is used for CFD simulations. The tables are bi-linearly interpolated for laminar simulations and tri-linearly interpolated for turbulent simulations. The tabulated chemistry can be hooked to commercial software such as Fluent through C and Scheme codes. The simulated flames presented here were computed with this software. The developed software is reliable for modeling and simulation of complex combustion phenomena.
APA, Harvard, Vancouver, ISO, and other styles
8

Perkins, John F., Richard H. Hopkins, Charles D. Brandt, Anant K. Agarwal, Suresh Seshadri, and Richard R. Siergiej. "SiC High Temperature Electronics for Next Generation Aircraft Controls Systems." In ASME 1996 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1996. http://dx.doi.org/10.1115/96-gt-106.

Full text
Abstract:
Several organizations, including Westinghouse, CREE, and ATM, as well as researchers in Japan and Europe, are working to develop SiC power devices for reliable, high power and high temperature environments in military, industrial, utility, and automotive applications. Other organizations, such as NASA Lewis and several universities, are also doing important basic work on basic SiC technology development. It has been recognized for two decades that the superior properties of SiC lead to range of devices with higher power, greater temperature tolerance, and significantly more radiation hardness than silicon or GaAs. This combination of superior thermal and electrical properties results in SiC devices that can operate at up to ten times the power density of Si devices for a given volume. Recent research has focused on the development of vertical metal oxide semiconductor field effect transistor (VMOSFET) power device technology, and complementary high speed, temperature-tolerant rectifier-diodes for power applications. We are also evaluating applications for field control thyristors (FCT) and MOS turn-off thyristors (MTO). The technical issues to be resolved for these devices are also common to other power device structures. The present paper reviews the relative benefits of various power devices structures, with emphasis on how the special properties of SiC enhance the desirability of specific device configurations as compared to the Si-based versions of these devices. Progress in SiC material quality and recent power device research will be reviewed, and the potential for SiC-based devices to operate at much higher temperatures than Si-based devices, or with enhanced reliability at higher temperatures will be stressed. We have already demonstrated 1000V breakdown, current densities of 1 kA/cm2, and measurements up to 400°C in small diodes. The extension of this work will enable the implementation of highly distributed aircraft power control systems, as well as actuator and signal conditioning electronics for next generation engine sensors, by permitting electronic circuits, sensors and smart actuators to be mounted on or at the engine.
APA, Harvard, Vancouver, ISO, and other styles
9

Elisa Cordeiro de Jesus, Ana, and Pietra Vaz Diógenes da Silva. "O NOVO MARCO LEGAL DE C, T e I E SEUS REFLEXOS EM MINAS GERAIS." In I Congresso de Ciência, Tecnologia e Inovação: Políticas e Leis. Belo Horizonte, Minas Gerais: Even3, 2018. http://dx.doi.org/10.29327/observalei.131559.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Fenton, J. W., J. I. Witting, and T. M. Miller. "THROMBIN KINETIC PARAMETERS WITH TRIPEPTIDE p-NITROANALIDES UNDER PHYSIOLOGICALLY RELEVANT CONDITIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643278.

Full text
Abstract:
The Michaelis-Menten (Km ), catalytic (kcat ), and specificity (kcat/Km ) constants were determined for humSft α- and β-thrombins with the chromogenic substrate S-2238 (H-D-Phe-Pip-Arg-pNA), Chromozym-TH (Tos-Gly-Pro-Arg-pNA), and Spectrozyme-TH (H-D-HHT-Ala-Arg-pNA) in 0.15 M NaCl buffered with 10 mM HEPES ancTlO mM Tris-HCT at pH 7.4, 37°C. Spontaneous hydrolysis was insignificant for these substrates. Both S-2238 and Spectrozyme-TH exhibited limiting solubilities at ∼35 μM, while Chromozym-TH did not do so up to 50 μM. From initial estimates, Km's and k t's were refined by computer Gause-Newton iterations or nonlinearneast-square fits for the concentration of p-nitroanalide formed per second versus the initial substrate concentration. No major differences were found between a-thrombin (99% α, 91% esterolytically active enzyme, and > 3,500 kilo-U.S. clotting units/g with fibrinogen) and Yγ-thrombin (98% γ. 89% active enzyme, and < 10 kilo-units/g). For α- versus γ-thrombin and the three substrates, respectively, the Km 's were 6.75 ± 0.13 vs 7.62 ± 0.30, 18.4 ± 0.4 vs 23.0 ± 0.3, and 2.53 ± 0.02 vs 3.85 ± 0.51 μM; the kcat> s were 125 ± 1 vs 134 ± 2, 181 ± 2 vs 130 ± 1, and 35.5 ± 0.2 vs 52.4 ± 2.0 s−1 ; and the kcat/Km 's were 18.5 vs 17.6, 9.84 vs 5.65, and 10.1 vs 13.6 s−1 μm . These values closely approximate those of 7.2 ± 0.9 μM, 84 ± 4 s−1 , and 11.7 s−1 μM−1 determined by Higgins, Lewis, and Shafer (J. Biol. Chem. 258:9276-9282, 1983) for the Aα cleavage of human fibrinogen by human α-thrombin under physiologically relevant conditions. Thus, these chromogenic substrates have thrombin specificities similar to that of fibrinogen, although their amidolytic activities are independent of additional active-site regions required for fibrinogen clotting activity (α vs γ-thrombin). Fibrinogen interactions with such active-site regions might account for why the fibrinogen Aa site is an atypical thrombin susceptible bond and the high species variability of fibrinopeptides. (Supported in part by NIH grant HL-13160).
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Lewis c"

1

Martin, Kathi, Nick Jushchyshyn, and Daniel Caulfield-Sriklad. 3D Interactive Panorama Jessie Franklin Turner Evening Gown c. 1932. Drexel Digital Museum, 2015. http://dx.doi.org/10.17918/9zd6-2x15.

Full text
Abstract:
The 3D Interactive Panorama provides multiple views and zoom in details of a bias cut evening gown by Jessie Franklin Turner, an American woman designer in the 1930s. The gown is constructed from pink 100% silk charmeuse with piping along the bodice edges and design lines. It has soft tucks at the neckline and small of back, a unique strap detail in the back and a self belt. The Interactive is part of the Drexel Digital Museum, an online archive of fashion images. The original gown is part of the Fox Historic Costume, Drexel University, a Gift of Mrs. Lewis H. Pearson 64-59-7.
APA, Harvard, Vancouver, ISO, and other styles
2

AIR FORCE MOBILITY CENTER POPE AFB NC. Environmental Assessment, Change in C-17 Flight Training Operations at Grant County International Airport, Washington by Joint Base Lewis-McChord. Fort Belvoir, VA: Defense Technical Information Center, October 2011. http://dx.doi.org/10.21236/ada607841.

Full text
APA, Harvard, Vancouver, ISO, and other styles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography