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Academic literature on the topic 'Leukocyte populations'

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Published: 9 March 2023
Last updated: 10 March 2023

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Journal articles on the topic "Leukocyte populations"

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Gaashan, Muaadh M., Abdullah I. A. Al-Mubarak, and Jamal Hussen. "Leukocyte populations and their cell adhesion molecules expression in newborn dromedary camel calves." Veterinary World 13, no. 9 (2020): 1863–69. http://dx.doi.org/10.14202/vetworld.2020.1863-1869.

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Background and Aim: Different properties of the newborn immune system have been characterized in many species. For the newborn camel calf, however, the phenotype and composition of blood leukocytes have so far not been evaluated. The current study aimed to analyze the distribution of leukocyte subpopulations and their expression pattern of cell adhesion molecules in newborn and adult dromedary camels. Materials and Methods: Blood samples were collected from 17 newborn camel calves and 32 adult camels. For each sample, total leukocytes were separated and analyzed for their composition and cell adhesion molecules expression by flow cytometry. Results: In comparison to adult camels, newborn camel calves had higher leukocyte numbers and higher numbers of neutrophils, monocytes, and lymphocytes but lower numbers of eosinophils in their blood. Among the lymphocyte populations in calves, the fractions of B cells and γδ T cells were elevated when compared to adults, whereas CD4-positive T cells were reduced. The comparison between camel calves and adult camels revealed significantly lower expression of the cell adhesion molecules CD11a, CD11b, and CD18 on granulocytes, monocytes, and lymphocytes in calves. Conclusion: Newborn camel calves show a distinct composition and phenotype pattern of blood leukocytes when compared to adult camels. The observed rise in many leukocyte populations in calf blood may be due to reduced migratory activity in calf leukocyte populations.
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Hibbert, Julie, Tobias Strunk, Elizabeth Nathan, Amy Prosser, Dorota Doherty, Karen Simmer, Peter Richmond, David Burgner, and Andrew Currie. "Composition of early life leukocyte populations in preterm infants with and without late-onset sepsis." PLOS ONE 17, no. 3 (March 2, 2022): e0264768. http://dx.doi.org/10.1371/journal.pone.0264768.

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Background Composition of leukocyte populations in the first month of life remains incompletely characterised, particularly in preterm infants who go on to develop late-onset sepsis (LOS). Aim To characterise and compare leukocyte populations in preterm infants with and without LOS during the first month of life. Study design Single-centre prospective observational cohort study. Participants Infants born <30 weeks gestational age (GA). Outcome measures Peripheral blood samples were collected at 1, 7, 14, 21 and 28 days of life. Leukocyte populations were characterised using 5-fluorophore-6-marker flow cytometry. Absolute leukocyte counts and frequency of total CD45+ leukocytes of each population were adjusted for GA, birth weight z-scores, sex and total leukocyte count. Results Of 119 preterm infants enrolled, 43 (36%) had confirmed or clinical LOS, with a median onset at 13 days (range 6–26). Compared to infants without LOS, the adjusted counts and frequency of neutrophils, basophils and non-cytotoxic T lymphocytes were generally lower and immature granulocytes were higher over the first month of life in infants who developed LOS. Specific time point comparisons identified lower adjusted neutrophil counts on the first day of life in those infants who developed LOS more than a week later, compared to those without LOS, albeit levels were within the normal age-adjusted range. Non-cytotoxic T lymphocyte counts and/or frequencies were lower in infants following LOS on days 21 and 28 when compared to those who did not develop LOS. Conclusion Changes in non-cytotoxic T lymphocytes occurred following LOS suggesting sepsis-induced immune suppression.
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Numazaki, K., H. Asanuma, and S. Chiba. "Human Cytomegalovirus Infection of Leukocyte Populations." Journal of Infectious Diseases 173, no. 2 (February 1, 1996): 503. http://dx.doi.org/10.1093/infdis/173.2.503.

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Stewart-Akers, Ann M., Joel S. Krasnow, and Julie A. Deloia. "Decidual leukocyte populations in ectopic pregnancies." Fertility and Sterility 68, no. 6 (December 1997): 1103–7. http://dx.doi.org/10.1016/s0015-0282(97)00417-2.

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Stosik, M., W. Deptuła, K. Wiktorowicz, M. Trávniček, and K. Baldy-Chudzik. "Qualitative and quantitative cytometric analysis of peripheral blood leukocytes in carps (Cyprinus carpio)." Veterinární Medicína 46, No. 5 (January 1, 2001): 149–52. http://dx.doi.org/10.17221/7871-vetmed.

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The studies were performed involving qualitative and quantitative cytometric analysis of peripheral blood leukocytes in healthy carps at various stages of their ontogeny, i.e., in 3- to 29-month old carps. Three populations of leukocyte line cells were distinguished, which differed in forward scatter (FSC) and side scatter (90o, SSC) of laser light. The most abundant leukocyte pool was present in the eldest (23- to 29-month old) fish. Lower numbers of the cells were observed in the youngest (3- to 9-month old) carps while the lowest levels of the cells were detected in carps of the moderate age (11- to 21-month old). The leukocyte populations, distinguished on grounds of FSC/SSC characteristics, were suggested to correspond to lymphocytes/thrombocytes (low FSC, low SSC), granulocytes (high FSC, high SSC) and monocytes (high FSC, low SSC).
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Becker, Daniel J., Elizabeth M. Schultz, Jonathan W. Atwell, and Ellen D. Ketterson. "Urban residency and leukocyte profiles in a traditionally migratory songbird." Animal Migration 6, no. 1 (January 1, 2019): 49–59. http://dx.doi.org/10.1515/ami-2019-0002.

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Abstract Many animals are shifting migrations in response to human activities. In particular, human-induced changes to climate and habitat (e.g., urbanization) likely facilitate animals becoming year-round residents. Because migration can be energetically expensive, shifts to sedentary behavior could minimize energetic demands incurred and any immunosuppressive effects. Residency in urban habitats could also provide abundant resources and allow sedentary animals to invest more in immunity. However, urban habitats could also expose sedentary animals to novel stressors that counter such benefits. To examine how recent shifts to residency affects physiology in ways that may shape infectious disease dynamics, we analyzed leukocyte profiles of two dark-eyed junco (Junco hyemalis) populations from southern California: the Laguna Mountain population, in which birds breed in high-elevation forests and migrate altitudinally, and the urban University of California San Diego population, which was likely established by overwintering migrants in the 1980s and has since become non-migratory. Over a two-year study of each population’s breeding season, we found no difference in the ratios of heterophils to lymphocytes between populations. However, urban residents had more leukocytes than birds from the altitudinal migrant population. A multivariate analysis suggested urban residents had fewer monocytes, but effect sizes were small. These results suggest no differences in energy demands or stressors between urban resident and altitudinal migrant populations during their breeding season. However, urban residency may confer immunological benefits through anthropogenic resources, which could have important consequences for disease dynamics..
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Criado, Ignacio, Wendy G. Nieto, Guillermo Oliva-Ariza, Blanca Fuentes-Herrero, Cristina Teodosio, Quentin Lecrevisse, Antonio Lopez, Alfonso Romero, Julia Almeida, and Alberto Orfao. "Age- and Sex-Matched Normal Leukocyte Subset Ranges in the General Population Defined with the EuroFlow Lymphocyte Screening Tube (LST) for Monoclonal B-Cell Lymphocytosis (MBL) vs. Non-MBL Subjects." Cancers 15, no. 1 (December 22, 2022): 58. http://dx.doi.org/10.3390/cancers15010058.

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Reference ranges of blood-circulating leukocyte populations by, e.g., age and sex, are required for monitoring immune-cell kinetics. Most previous reports in which flow cytometry has been used to define the reference ranges for leukocyte counts included a limited number of donors and/or cell populations and/or did not consider age and sex simultaneously. Moreover, other factors not previously considered in the definition of normal ranges, such as the presence of chronic-lymphocytic-leukemia (CLL)-like low-count monoclonal B-cell lymphocytosis (MBLlo), might also be associated with an altered distribution of leukocytes in blood in association with an immunodeficiency and increased risk of infection and cancer. Here, we established reference cell-count ranges for the major populations of leukocytes in blood of non-MBL and MBLlo adult Caucasians matched by age and sex using the EuroFlow Lymphocyte Screening Tube (LST). A total of 706 Caucasian adult donors—622 non-MBL and 84 MBLlo—were recruited from the general population. Among non-MBL donors, the total leukocyte, neutrophil, basophil dendritic cell and monocyte counts remained stable through adulthood, while the absolute numbers of T- and B-cell populations and plasma cells decreased with age. The number of eosinophils and NK-cell increased over time, with clear differences according to sex for certain age ranges. In MBLlo subjects, few differences in the absolute cell counts by age (vs. non-MBL) were observed, and MBLlo men and women showed similar trends to non-MBL subjects except for the B-cell count drop observed in >70 y-men, which was more pronounced in MBLlo vs. non-MBL controls. Building robust age- and sex-matched reference ranges for the most relevant immune-cell populations in the blood of non-MBL donors is essential to appropriately identify an altered immune status in different clinical settings and highlight the altered immune-cell profiles of MBLlo subjects.
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Romanova, E. B., I. A. Stolyarova, A. G. Bakiev, and R. A. Gorelov. "Comparative leukocyte blood profile of Emys orbicularis (Reptilia: Emydidae) from two populations." Current Studies in Herpetology 21, no. 1/2 (June 21, 2021): 30–42. http://dx.doi.org/10.18500/1814-6090-2021-21-1-2-30-42.

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A comparative estimation of the leukocyte profile of the marsh turtle Emys orbicularis (Linnaeus, 1758) living in the Ural river basin (Orenburg region, Belyaevsky district, 11 females and 5 males) and in the Volga river basin (Astrakhan region, Krasnoyarsk district, 28 females and 20 males) was made. The blood formula (WBC) of males and females was calculated together with the calculation of integral leukocytal indices (the lymphocyte-granulocyte index, the leukocyte shift index, the heterophile/lymphocyte ratio, the heterophil/eosinophil ratio, and the lymphocyte/eosinophil ratio). Lymphocytes were the predominant leukocyte cells in the peripheral blood of Emys orbicularis (40–45%). Among granulocytes, heterophiles (the population from the Orenburg region) or basophils (the population from the Astrakhan region) predominated. The absence of any differences in the quantitative indicators of the blood formula and integral indices for males and females indicated a comparable level of impact and identity of the physiological adaptation mechanisms occurring in the animals in the Orenburg region. Intersexual differences were manifested in an increased content of monocytes (u = 3.13, p = 0.001), which indicated activation of the natural immunity of males in comparison with females from the Astrakhan region. The leukocyte composition of the Emys orbicularis blood differed in the content of granulocytes and agranulocytes in different populations. The males from the Orenburg region differed from those from the Astrakhan region by an increased proportion of heterophiles and a reduced content of basophils. Females differed in all blood count parameters, except for eosinophils whose fraction was equal (u = 0.71, p = 1.00). In the peripheral blood of females from the Orenburg region, a higher content of heterophiles, monocytes and a lower content of basophils and lymphocytes were found in comparison with those from the Astrakhan region. Quantitative-qualitative changes were detected in the leukocyte composition of the blood during the invasion of hemoparasites. The specific immune response (the content of lymphocytes) decreased, and the nonspecific defense system (the content of heterophiles) increased. The maintenance of the immunological reactivity of the organism under the conditions of invasion was determined by the functional activity of heterophiles, which was confirmed by a higher value of the heterophil/lymphocyte index. The blood formula (WBC) and the dynamics of leukocytal indexes of Emys orbicularis reflected the active response of the organism to a complex of environmental factors, including parasitic invasions.
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Patel, Brijesh V., Kate C. Tatham, Michael R. Wilson, Kieran P. O'Dea, and Masao Takata. "In vivo compartmental analysis of leukocytes in mouse lungs." American Journal of Physiology-Lung Cellular and Molecular Physiology 309, no. 7 (October 1, 2015): L639—L652. http://dx.doi.org/10.1152/ajplung.00140.2015.

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The lung has a unique structure consisting of three functionally different compartments (alveolar, interstitial, and vascular) situated in an extreme proximity. Current methods to localize lung leukocytes using bronchoalveolar lavage and/or lung perfusion have significant limitations for determination of location and phenotype of leukocytes. Here we present a novel method using in vivo antibody labeling to enable accurate compartmental localization/quantification and phenotyping of mouse lung leukocytes. Anesthetized C57BL/6 mice received combined in vivo intravenous and intratracheal labeling with fluorophore-conjugated anti-CD45 antibodies, and lung single-cell suspensions were analyzed by flow cytometry. The combined in vivo intravenous and intratracheal CD45 labeling enabled robust separation of the alveolar, interstitial, and vascular compartments of the lung. In naive mice, the alveolar compartment consisted predominantly of resident alveolar macrophages. The interstitial compartment, gated by events negative for both intratracheal and intravenous CD45 staining, showed two conventional dendritic cell populations, as well as a Ly6Clo monocyte population. Expression levels of MHCII on these interstitial monocytes were much higher than on the vascular Ly6Clo monocyte populations. In mice exposed to acid aspiration-induced lung injury, this protocol also clearly distinguished the three lung compartments showing the dynamic trafficking of neutrophils and exudative monocytes across the lung compartments during inflammation and resolution. This simple in vivo dual-labeling technique substantially increases the accuracy and depth of lung flow cytometric analysis, facilitates a more comprehensive examination of lung leukocyte pools, and enables the investigation of previously poorly defined “interstitial” leukocyte populations during models of inflammatory lung diseases.
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Tshabalala, Mqondisi, Juanita Mellet, and Michael S. Pepper. "Human Leukocyte Antigen Diversity: A Southern African Perspective." Journal of Immunology Research 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/746151.

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Despite the increasingly well-documented evidence of high genetic, ethnic, and linguistic diversity amongst African populations, there is limited data on human leukocyte antigen (HLA) diversity in these populations. HLA is part of the host defense mechanism mediated through antigen presentation to effector cells of the immune system. With the high disease burden in southern Africa, HLA diversity data is increasingly important in the design of population-specific vaccines and the improvement of transplantation therapeutic interventions. This review highlights the paucity of HLA diversity data amongst southern African populations and defines a need for information of this kind. This information will support disease association studies, provide guidance in vaccine design, and improve transplantation outcomes.
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Dissertations / Theses on the topic "Leukocyte populations"

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Kourosh, Rasekh Ahmadi. "Genetic control of human peripheral blood leukocyte populations." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289879.

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Ho, Chak Sum Smith Douglas M. "Molecular characterization of swine leukocyte antigen diversity in outbred pig populations." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/5012.

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Manickasingham, Shrivanthi Prithiva. "The effects on Langerhans cells and dermal leukocyte populations of agents which trigger herpes simplex reactivation." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337696.

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Lazaryan, Aleksandr. "Human leukocyte antigen supertypes in relation to human imunodeficiency virus infection among populations of African ancestry." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/lazaryan.pdf.

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Lutje, Vittoria. "Proliferative and antibody responses induced by pokeweed mitogen, sheep erythrocytes and ovalbumin in bovine leukocyte populations and the cellular interactions involved." Thesis, Brunel University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280691.

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Vettore, Marina. "The immunological landscape of primary brain tumors: a comparative study of the immunosuppressive myeloid cell populations in benign and malignant tumors." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426697.

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The immune system plays a dual role in cancer progression, either preventing or promoting tumor progression and the fine regulation of the complex interaction between immune system and tumor determines patient outcome. It has been demonstrated that also in brain tumors a combination of signals and soluble factors secreted by tumor, immune and stromal cells are able to potentiate tumor progression. Therefore, the interest towards the characterization of tumor microenvironment in these tumors is growing and the presence of tumor infiltrating immune cells of myeloid origin has already been reported, but a clear phenotypic and functional characterization in human brain tumors still lacking. For this reason, in this research project we performed a deep analysis of both circulating and tumor-infiltrating leukocytes present in meningioma (MNG) and glioblastoma (GBM) patients in order to dissect their properties, with the ultimate goal of finding new immunological therapeutic strategies. We thus performed an extensive immunophenotyping of peripheral blood and fresh tumor tissue at surgery by multiparametric flow cytometry in 34 patients affected by MNG (WHO grade I-II) and in 76 patients affected by GBM (WHO grade IV glioma), along with immunosuppressive activity of sorted cells of myeloid origin. In the peripheral blood, we observed a number of significant alterations in myeloid cell subsets indicating a specific monocyte subsets as the main cell subset actively recruited to the tumor. Moreover, four subsets of myeloid-derived suppressor cells (MDSCs) are detectable in the blood and in the tumor tissue of patients affected by MNG and GBM. Three of these subsets are significantly expanded in the blood of patients, whereas two of them are significantly expanded in the tumor tissue. In addition, we assayed ARG-1 (arginase 1) levels and activity in plasma samples from patients affected by MNG and GBM, and observed both a significantly increased level and a boost of its functional activity, compared to the control group. At the tumor site, we observed a large leukocyte infiltrate, predominantly constituted by CD33+ myeloid cells, largely composed of macrophages endowed with suppressive activity and significantly expanded in both types of tumor. Based on the expression of different markers, in GBM patients, we were able to discriminate bone marrow-derived (BMDM) macrophages from resident microglia (MG). These populations showed a different suppressive activity, since BMDMs displayed a higher immunosuppressive activity compared to MG cells that showed low or no suppressive immune regulatory ability. Taken together the results of this study shed light on the complex interaction between immune system and the main tumors of the brain.
Il sistema immunitario svolge un duplice ruolo nella progressione del cancro, è in grado sia di prevenire che di promuovere la progressione tumorale e la regolazione della complessa interazione tra sistema immunitario ed il tumore è in grado di determinare la prognosi del paziente. Inoltre, è stato dimostrato che, anche nei tumori cerebrali, una combinazione di segnali e di fattori solubili secreti dal tumore, dalle cellule immunitarie e dalle cellule stromali, è in grado di potenziare la progressione tumorale. Pertanto, in questi tumori sta crescendo l'interesse verso la caratterizzazione del microambiente tumorale ed è già stata dimostrata la presenza di cellule immunitarie di origine mieloide infiltranti il tumore, ma una chiara caratterizzazione fenotipica e funzionale di queste popolazioni non è ancora stata documentata. Pertanto, in questo progetto di ricerca abbiamo eseguito un'analisi approfondita sia dei leucociti circolanti che dei leucociti infiltranti il tumore nei pazienti affetti da meningioma (MNG) e glioblastoma (GBM), al fine di studiarne le caratteristiche, con l'obiettivo finale di trovare nuove strategie terapeutiche. Abbiamo pertanto eseguito un’accurata immunofenotipizzazione del sangue periferico e del tessuto tumorale, analizzato subito dopo la resezione chirurgica, mediante citofluorimetria a flusso multi-parametrica in 34 pazienti con MNG (grado I-II OMS) e in 76 pazienti con GBM (glioma di grado IV OMS). Abbiamo inoltre testato l’attività immunosoppressiva delle popolazioni di origine mieloide isolate da biopsia. Nel sangue periferico abbiamo osservato delle alterazioni significative nelle sottopopolazioni di cellule di origine mieloide, rivelando che un particolare sottogruppo di monociti viene attivamente reclutato al sito tumorale. Inoltre, quattro sottopopolazioni di cellule soppressorie di derivazione mieloide (MDSC) sono rilevabili nel sangue e nel tessuto tumorale dei pazienti affetti da MNG e GBM. Tre di queste popolazioni sono significativamente espanse nel sangue dei pazienti, mentre due di esse sono significativamente espanse nel tessuto tumorale. In questo studio, abbiamo analizzato anche i livelli plasmatici di arginasi 1 (ARG-1) e la sua attività funzionale in campioni di plasma di pazienti con MNG o GBM ed abbiamo osservato sia un aumento significativo della sua concentrazione plasmatica che della sua attività funzionale, rispetto al gruppo di controllo. Analizzando il tessuto tumorale, abbiamo osservato la presenza di un importante infiltrato leucocitario, costituito prevalentemente da cellule mieloidi CD33+ ed in particolare da macrofagi dotati di attività soppressiva e la cui percentuale è notevolmente elevata in entrambi i tipi di tumore. Nei pazienti con GBM, sulla base dell'espressione di diversi marcatori, abbiamo potuto discriminare i macrofagi derivati dal midollo osseo (BMDM) dalla microglia (MG). Queste popolazioni macrofagiche hanno dimostrato avere una diversa attività soppressoria, infatti, i BMDM risultano essere più immunosoppressivi rispetto alla MG che invece ha una bassa o irrilevante capacità soppressoria. I risultati di questo studio sottolineano quindi l’esistenza di una complessa interazione tra sistema immunitario ed i principali tumori cerebrali.
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Schäkel, Knut, Claudia Poppe, Elfriede Mayer, Christine Federle, Gert Riethmüller, and Ernst Peter Rieber. "M-DC8+ Leukocytes – A Novel Human Dendritic Cell Population." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135252.

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Dendritic cells (DC) constitute a heterogeneous leukocyte population having in common a unique capacity to induce primary T cell responses and are therefore most attractive candidates for immunomodulatory strategies. Two populations of blood DC (CD11c+ CD123dim and CD11c– CD123high) have been defined so far. However, their direct isolation for experimental purposes is hampered by their low frequency and by the lack of selective markers allowing large scale purification from blood. Here we describe the monoclonal antibody (mAb) M-DC8, which was generated by immunizing mice with highly enriched blood DC. This mAb specifically reacts with 0.2–1% of blood leukocytes and enables their direct isolation by a one-step immunomagnetic procedure from fresh mononuclear cells. These cells can be differentiated from T cells, B cells, NK cells and monocytes using lineage-specific antibodies. M-DC8+ cells express HLA class II molecules, CD33 and low levels of the costimulatory molecules CD86 and CD40. Upon in vitro culture M-DC8+ cells spontaneously mature into cells with the phenotype of highly stimulatory cells as documented by the upregulation of HLA-DR, CD86 and CD40; in parallel CD80 expression is induced. M-DC8+ cells display an outstanding capacity to present antigen. In particular, they proved to be excellent stimulators of autologous mixed leukocyte reaction and to activate T cells against primary antigens such as keyhole limpet hemocyanin. Furthermore, they induce differentiation of purified allogeneic cytotoxic T cells into alloantigen-specific cytotoxic effector cells. While the phenotypical analysis reveals similarities with the two known blood DC populations, the characteristic expression of Fc=γRIII (CD16) and the M-DC8 antigen clearly defines them as a novel population of blood DC. The mAb M-DC8 might thus be a valuable tool to determine circulating DC for diagnostic purposes and to isolate these cells for studies of antigen-specific T cell priming
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
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Schäkel, Knut, Claudia Poppe, Elfriede Mayer, Christine Federle, Gert Riethmüller, and Ernst Peter Rieber. "M-DC8+ Leukocytes – A Novel Human Dendritic Cell Population." Karger, 1999. https://tud.qucosa.de/id/qucosa%3A27632.

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Dendritic cells (DC) constitute a heterogeneous leukocyte population having in common a unique capacity to induce primary T cell responses and are therefore most attractive candidates for immunomodulatory strategies. Two populations of blood DC (CD11c+ CD123dim and CD11c– CD123high) have been defined so far. However, their direct isolation for experimental purposes is hampered by their low frequency and by the lack of selective markers allowing large scale purification from blood. Here we describe the monoclonal antibody (mAb) M-DC8, which was generated by immunizing mice with highly enriched blood DC. This mAb specifically reacts with 0.2–1% of blood leukocytes and enables their direct isolation by a one-step immunomagnetic procedure from fresh mononuclear cells. These cells can be differentiated from T cells, B cells, NK cells and monocytes using lineage-specific antibodies. M-DC8+ cells express HLA class II molecules, CD33 and low levels of the costimulatory molecules CD86 and CD40. Upon in vitro culture M-DC8+ cells spontaneously mature into cells with the phenotype of highly stimulatory cells as documented by the upregulation of HLA-DR, CD86 and CD40; in parallel CD80 expression is induced. M-DC8+ cells display an outstanding capacity to present antigen. In particular, they proved to be excellent stimulators of autologous mixed leukocyte reaction and to activate T cells against primary antigens such as keyhole limpet hemocyanin. Furthermore, they induce differentiation of purified allogeneic cytotoxic T cells into alloantigen-specific cytotoxic effector cells. While the phenotypical analysis reveals similarities with the two known blood DC populations, the characteristic expression of Fc=γRIII (CD16) and the M-DC8 antigen clearly defines them as a novel population of blood DC. The mAb M-DC8 might thus be a valuable tool to determine circulating DC for diagnostic purposes and to isolate these cells for studies of antigen-specific T cell priming.
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
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MEAZZI, SARA. "THE INTERPLAY BETWEEN HOST DEFENSES AND SYSTEMIC PATHOGENS IN PROMOTING DISEASES OF COMPANION ANIMALS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/709076.

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Il microbiota intestinale (insieme dei microrganismi che si trovano all’interno dell’apparato gastroenterico) svolge diverse funzioni e, tra queste, di particolare interesse è il suo rapporto con il sistema immunitario. Infatti, diversi studi hanno evidenziato la presenza di disbiosi non solo in corso di patologie gastroenteriche, ma anche autoimmuni ed infettive. Gli studi in medicina veterinaria sull’argomento sono ancora pochi e proprio per questo motivo, all’interno di questo progetto, è stato scelto di indagare la possibile relazione tra il microbiota intestinale e due particolari patologie infettive (la peritonite infettiva felina -FIP- e la leishmaniosi canina) la cui patogenesi è fortemente influenzata dal tipo di risposta immunitaria sviluppata dall’ospite. Gli scopi di questo progetto sono quindi stati: la valutazione del microbiota intestinale in gatti affetti o meno da FIP (studio I). Dal momento che diagnosi in vivo di FIP risulta spesso difficoltosa, è stato valutato il potenziale, come biomarker di FIP, della paraoxonasi-1, una proteina di fase acuta negativa fortemente influenzata da importanti stati ossidativi (studi II e III). Per lo stesso motivo è stata valutata la correlazione tra le performance diagnostiche di istopatologia, immunoistochimica e RT-PCR su differenti organi (studio IV). Infine, è stata indagata la composizione del microbiota intestinale in cani infetti o meno da Leishmania spp., correlando i risultati ottenuti con le differenti popolazioni leucocitarie valutate mediante citofluorimetria (studi V e VI). I risultati ottenuti da questo progetto hanno fornito delle indicazioni preliminari sulla composizione del microbiota intestinale in gatti affetti da FIP o positivi per Coronavirus, che necessitano però un approfondimento su un gruppo di studio più ampio (studio I). È stato possibile determinare gli intervalli di riferimento della paraoxonasi-1 nel gatto ed evidenziare le sue buone performance come marker diagnostico in corso di FIP (studi II e III). Nonostante l’immunoistochimica rimanga il gold standard per la diagnosi di FIP, l’associazione con RT-PCR potrebbe ridurre gli errori diagnostici, vista la buona correlazione tra le due metodiche (studio IV). Infine, la valutazione della composizione del microbiota e delle popolazioni leucocitarie in cani affetti da leishmaniosi ha messo in luce delle differenze significative sia rispetto ai cani sani, che agli esposti asintomatici. Questi risultati sono incoraggianti e possono fungere da punto di partenza per ulteriori indagini (studi V e VI).
The gut microbiota (consortium of all the microorganisms that inhabit the gastrointestinal tract) plays different roles in the host. Among these, its relationship with the immune system has been of great interest in the last few years. Indeed, several studies highlight the presence of dysbiosis not only in gastrointestinal diseases, but also during autoimmune or infectious diseases. Literature about this topic is scarce in veterinary medicine. Thus, in this project, the possible relationship between gut microbiota and two specific diseases (feline infectious peritonis -FIP- and canine leishmaniasis) was investigated. These diseases were chosen due to the pivotal role of the immune response in their pathogenesis. The aims of this projects were: the evaluation of gut microbiota of cats with and without FIP (study I). Since in vivo diagnosis of FIP is quite challenging, the potential role of paroxonase-1 (a negative acute phase protein strongly influenced by oxidation) as a biomarker of FIP was investigated (studies II-III). For the same reason, the diagnostic agreement among histopathology, immunohistochemistry and RT-PCR on different organs was evaluated (study IV). Finally, the gut microbiota composition in dogs infected or not by Leishmania spp. was investigated. The results were correlated with the leukocyte populations studied by flow cytometry (studies V-VI). Results obtained in this project provided preliminary data about gut microbiota composition in cats affected by FIP or only Coronavirus positive. This achievement needs to be further investigated on a bigger sample size (study I). Paraoxonase-1 reference interval and its good performance as a diagnostic biomarker of FIP were determined (studies II-III). Despite the immunohistochemistry is still the gold standard for FIP diagnosis, the good diagnostic agreement obtained in the study suggested that a possible association with RT-PCR could minimize diagnostic errors (study IV). Finally, the gut microbiota composition and leukocyte populations of leishmaniotic dogs highlighted some significant differences compared with both healthy and exposed asymptomatic dogs. These promising results could be a starting point for further researches (studies V-VI).
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Salie, Muneeb. "The role of the major histocompatibility complex and the Leukocyte receptor complex genes in susceptibility to tuberculosis in a South African population." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86715.

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Thesis (PhD)--Stellenbosch University, 2014.
ENGLISH ABSTRACT: Tuberculosis (TB) disease results in approximately 2 million deaths annually and is the leading cause of death due to a single infectious agent. Previous studies have indicated that host genetics play an important role in the development of TB. This together with pathogen and environmental factors intensifies the complexity of this disease. The Major Histocompatibility Complex (MHC) and Leukocyte Receptor Complex (LRC) comprise several genes which are known to be important modulators of the host immune response. The human leukocyte antigen (HLA) class-I genes of the MHC are involved in the presentation of pathogenic antigens on the surfaces of infected cells, while the killer cell immunoglobulin-like receptors (KIRs) of the LRC are involved in the recognition of self and non-self cells. Natural Killer (NK) cells through their KIRs are thus able to kill non-self cells through recognition of the class-I molecules expressed. Additionally, HLAs and KIRs are extremely polymorphic and differ markedly across populations of different ethnicities. Here we studied these genes and their polymorphisms in the South African Coloured (SAC) population to determine their involvement in susceptibility to TB, susceptibility to disease caused by specific Mycobacterium tuberculosis subtypes, and understanding their ancestral contribution to the SAC with regards to the development of TB. We showed that the KIR3DS1 gene and KIR genotypes with five or more activating KIRs, and the presence of 3DS1, protected against the development of active TB in the SAC population. Several HLA class-I alleles were identified as susceptibility factors for TB disease. With regards to genes of the MHC and LRC, several loci were found to alter susceptibility to TB in the SAC population, including MDC1, BTNL2, HLA-DOA, HLA-DOB, C6orf10, TAP2, LILRA5, NCR1, NLRP7 and the intergenic regions between HLA-C/WASF5P and LAIR1/TTYH1. We showed that the Beijing strain occurred more frequently in individuals with multiple disease episodes, with the HLA-B27 allele lowering the odds of having an additional episode. Associations were identified for specific HLA types and disease caused by the Beijing, Latin America-Mediterranean (LAM), Low-Copy Clade (LCC), and Quebec strains. HLA types were associated with disease caused by strains from the Euro-American or East Asian lineages, and the frequencies of these alleles in their sympatric human populations identified potential co-evolutionary events between host and pathogen. Finally, we showed that the SAC population is the most diverse SA population with regards to HLA alleles and KIR genotypes, as would be expected given the admixture of the SAC. Based on the HLA allele class-I profiles across SA populations, we noted that the Ag85BESAT- 6, Ag85B-TB10.4 and Mtb72f vaccines currently undergoing clinical trials would have low efficacy across most SA populations. We showed that the MHC and LRC regions in SAC healthy controls are predominantly of European ancestry, and that SAC TB cases are more closely related to Khoisan and black SA population groups. Our work highlights the importance of investigating both host and pathogen genetics when studying TB disease development and that understanding the genetic ancestral contributions to the SAC population can contribute to the identification of true and novel TB causing variants.
AFRIKAANSE OPSOMMING: Tuberkulose (TB) is jaarliks verantwoordelik vir ongeveer 2 miljoen sterftes en is die hoofoorsaak van dood as gevolg van „n aansteeklike siekte. Vorige navorsingstudies het aangedui dat die genetiese samestelling van die gasheer „n beduidende rol speel in die ontwikkeling van TB. Die kompleksiteit van hierdie siekte word vererger deur die betrokkenheid van die gasheer genoom sowel as bakteriële en omgewings faktore. Die Major Histocompatibility Complex (MHC) en Leukocyte Receptor Complex (LRC) bestaan uit verskeie gene wat die gasheer immuunrespons verstel. Die human leukocyte antigen (HLA) klas I gene van die MHC is betrokke by die aanbieding van patogeniese antigene op die oppervlak van geïnfekteerde selle, terwyl die killer cell immunoglobulin-like receptors (KIRs), geleë in die LRC, betrokke is by die herkenning van eie en vreemde selle. NK selle, deur middel van hul KIRs, kan dus vreemde selle uitwis aangesien hulle die uitgedrukte klas I molekules kan herken. Beide HLA en KIRs is hoogs polimorfies en verskil beduidend tussen etniese groepe. In hierdie studie is die bogenoemde gene en hul polimorfismes in die Suid Afrikaanse Kleurling bevolking (SAC) ondersoek om vas te stel tot watter mate dit genetiese vatbaarheid vir TB, asook vatbaarheid vir TB wat deur spesifieke Mycobacterium tuberculosis subtipes veroorsaak word, beïnvloed. Daar is ook gepoog om te verstaan hoe die voorouerlike bydrae van hierdie gene die SAC met betrekking tot TB vatbaarheid affekteer. Die resultate van die studie het aangedui dat die KIR3DS1 geen en KIR genotipes met vyf of meer aktiewe KIRs en die teenwoordigheid van 3DS1, die SAC bevolking beskerm teen die ontwikkeling van aktiewe TB. Verskeie HLA klas I allele is geïdentifiseer as vatbaarheidsfaktore vir TB. Talle lokusse van die MHC en LRC gene is ook as vatbaarheidsfaktore vir TB in die SAC bevolking geïdentifiseer, insluitende MDC1, BTNL2, HLA-DOA, HLA-DOB, C6orf10, TAP2, LILRA5, NCR1, NLRP7 en die intergeniese areas tussen HLA-C/WASF5P en LAIR1/TTYH1. Die studie het aangedui dat die Beijing stam meer voorkom in individue wat verskeie kere TB gehad het en dat die HLA-B27 alleel die kanse om „n verdere episode te hê, verlaag het. Assosiasies is geïdentifiseer tussen spesifieke HLA tipes en siekte veroorsaak deur die Beijing, LAM, LCC, en Quebec TB stamme. HLA tipes was geassosieer met siekte veroorsaak deur TB stamme van Euro-Amerikaanse en Oos-Asiëse afkoms. Die frekwensies van hierdie allele, in hul ooreenstemmende mensbevolkings, dui op „n potensïele koevolusionêre gebeurtenis tussen die gasheer en patogeen. Die studie het ook vasgestel dat die SAC populasie die mees diverse SA bevolking is met betrekking tot die HLA allele en KIR genotipes, soos verwag sou word gegewe die gemengde genetiese herkoms van die SAC. Gebaseer op die HLA allele klas I profiel van verskillende SA bevolkings merk ons op dat die Ag85B-ESAT-6, Ag85B-TB10.4 en Mtb72f vaksiene, wat huidiglik kliniese toetsing ondergaan, nie so effektief in die meeste SA bevolkings sal wees nie. Die studie het ook bewys dat die MHC en LRC streke in gesonde SAC kontroles, grootliks afkomstig was van „n Europese nalatenskap en dat die SAC TB gevalle meer verwant is aan die Khoisan en swart SA bevolkings. Hierdie studie beklemtoon die noodsaaklikheid om beide gasheer en patogeen genetika te bestudeer wanneer die ontwikkeling van TB ondersoek word en dat die verstaan van die genetiese voorouerlike bydrae van die SAC bevolking kan bydra tot die identifisering van ware en nuwe TB-veroorsakende variante.
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Books on the topic "Leukocyte populations"

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Lutje, Vittoria. Proliferative and antibody responses induced by pokeweed mitogen, sheep erythrocytes and ovalbumin in bovine leukocyte populations, and the cellular interactions involved. Uxbridge: Brunel University, 1989.

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Gensler, Lianne, Michael Weisman, and Liron Caplan. Epidemiology of axial spondyloarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198734444.003.0002.

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Axial spondyloarthritis (axSpA) is an inflammatory arthritis of the sacroiliac joints and spine. The prototype is ankylosing spondylitis, the radiographic form of the disease; however, more recently, an earlier or less-differentiated presentation has been described termed non-radiographic axial spondyloarthritis (nr-axSpA). Extra-articular manifestations commonly include anterior uveitis, inflammatory bowel disease, and psoriasis. There is a strong association with the human leukocyte antigen B27 (HLA-B27) allele, and the prevalence of the disease tends to follow the frequency of the allele. Epidemiological studies in axSpA are relevant in the population studied and therefore have limited external validity. This chapter describes the epidemiology of axSpA.
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Book chapters on the topic "Leukocyte populations"

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Anderson, Kenneth C., Andrew W. Boyd, David C. Fisher, John F. Daley, Stuart F. Schlossman, and Lee M. Nadler. "Human B Cell Populations Defined by the B1 and B2 Antigens." In Leukocyte Typing II, 413–28. New York, NY: Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4612-4848-4_35.

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Butcher, Matthew J., Michelle B. Trevino, Yumi Imai, and Elena V. Galkina. "Characterization of Islet Leukocyte Populations in Human and Murine Islets by Flow Cytometry." In Methods in Molecular Biology, 185–97. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9882-1_10.

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Zola, Heddy. "Human B Cells: Is FMC7 a Marker for Relatively Mature B Cells or Does It Define a Population Equivalent to the LyB5-Negative Mouse B Cells?" In Leukocyte Typing II, 141–45. New York, NY: Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4612-4848-4_10.

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Jinam, Timothy A. "Human Leukocyte Antigen (HLA) Region in Human Population Studies." In Evolution of the Human Genome I, 173–79. Tokyo: Springer Japan, 2017. http://dx.doi.org/10.1007/978-4-431-56603-8_9.

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Madden, John J., Arthur Falek, David A. Shafer, Robert M. Donahoe, Deborah C. Eltzroth, Felicia Hollingsworth, and Peter J. Bokos. "Influence of Demographic Factors on Scheduled DNA Synthesis as Measured in Human Peripheral Leukocytes and Fibroblasts." In Individual Susceptibility to Genotoxic Agents in the Human Population, 359–71. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2765-3_23.

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Scheffold, Alexander, Andreas Radbruch, and Mario Assenmacher. "Phenotyping and separation of leukocyte populations based on affinity labelling." In Immunology of Infection, 23–58. Elsevier, 2002. http://dx.doi.org/10.1016/s0580-9517(02)32086-5.

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Scheffold, A., and A. Radbruch. "1 Phenotyping and Separation of Leukocyte Populations Based on Affinity Labelling." In Immunology of Infection, 22–57. Elsevier, 1998. http://dx.doi.org/10.1016/s0580-9517(08)70676-7.

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Erlebacher, Adrian. "Leukocyte Population Dynamics and Functions at the Maternal–Fetal Interface." In The Guide to Investigation of Mouse Pregnancy, 227–42. Elsevier, 2014. http://dx.doi.org/10.1016/b978-0-12-394445-0.00019-9.

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Hellewell, Sarah C., Bridgette D. Semple, Jenna M. Ziebell, Nicole Bye, and Cristina Morganti-Kossmann. "The Role of Inflammation in Traumatic Brain Injury." In Neurotrauma, edited by Lijun Bai, Shan Wang, and Chuanzhu Sun, 211–32. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190279431.003.0019.

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Inflammation occurring following brain trauma represents a significant constituent of complex secondary responses that dictate patients’ outcome. Although a few decades have passed since its discovery, new aspects of this intriguing phenomenon are still being uncovered, ranging from the multiple roles of mediators regulating the inception, progression, and resolution of neuroinflammation, to the development of antiinflammatory therapies. This review provides a summary of the vast research on traumatic brain injury inflammation. The authors describe the fundamental aspects of cytokine and immune cell functions, the orchestrated collaboration of chemokines and leukocytes, the phenotypic distinction of macrophage populations, and the contribution of glial cells. Among the beneficial properties of neuroinflammation, they briefly discuss cytokines’ impact on neurogenesis; the chapter concludes by touching on the implications of antiinflammatory therapies.
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Urrechaga, Eloísa. "Morphometric Parameters of Leukocytes in the Management of Sepsis Running Title: Cell Population Data in Sepsis." In Highlights on Medicine and Medical Research Vol. 9, 44–58. Book Publisher International (a part of SCIENCEDOMAIN International), 2021. http://dx.doi.org/10.9734/bpi/hmmr/v9/8560d.

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Conference papers on the topic "Leukocyte populations"

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Shahar, Ehud, Raphael Gorodetsky, Elina Aizenshtein, and Jacob Pitcovski. "Abstract 3633: Combination of innate immune activators stimulates leukocyte populations in the tumor microenvironment." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3633.

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Krueger, Joseph S., Brian Laffin, Holger Lange, Anthony Milici, Eric Neeley, Mirza Peljto, Mahipal Suraneni, and David Young. "Abstract 2548: Using whole slide digital image analysis to quantify leukocyte populations in tumor sections." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2548.

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Melzer, Susanne, Markus Löffler, Marlene Kautzner, and Attila Tárnok. "New mononuclear leukocyte-like populations within the granulocyte scatter gate detected by flow cytometry (Conference Presentation)." In Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XV, edited by Daniel L. Farkas, Dan V. Nicolau, and Robert C. Leif. SPIE, 2017. http://dx.doi.org/10.1117/12.2248622.

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Hoogasiam, J., M. Fisher, P. H. Levine, B. W. Weiner, C. H. Vaudreuil, A. Natale, and M. Johnson. "THE EFFECT OF DIETARY COD LIVER OIL SUPPLEMENTATION ON LEUKOCYTE PHYSIOLOGY; A POSSIBLE MEDIATOR OF THE ANTIATHEROGENIC EFFECT OF MARINE OIL." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643154.

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Leukocytes appear to be important in the pathophysiology of atherogenesis. Fish oil derived, omega-3 fatty acids suppress atherogenesis in experimental atherosclerosis models and select human populations. We assessed the effect of dietary cod liver oil (CLO) supplementation for 6 weeks on human monocyte and polymorphonuclear leukocyte (PMN) inflammatory potential in healthy controls and patients with a purported autoimmune disorder, multiple sclerosis (MS) in whom monocytes appear to be chronically activated. Baseline and 6 week venous blood samples were obtained from 6 stable MS patients and 6 healthy controls. . Monocyte hydrogen peroxide (HO) production (pMoles/minute/Ix10 monocytes) was measured in a spectrophotofluorometer after stimulation with latex particles. Baseline H2O2 production was 1.551.60 (mean 1 S.D.) in the MS patients and 1.19± .49 in the controls. Post-CLO the values were 1.021.24 and 1.091.27 respectively, representing a significant decline with CLO supplementation in the MS group (P< .01). PMN chemiluminescence (counts x10 /5min/PMN) levels was assessed by a liquid scintillation counter after stimulation with latex particles. Baseline levels were 17.416.1 in the MS group and 17.814.8 in the controls Post-CLO the levels were 12.812.3 and 12.313.3; both signifi-antly lower than baseline (P < .05). PMN superoxide (0 —) levels (nMoles/20min/lxl0 PMN) were measured by the reduction of cyto-chrome-c after stimulation with zymosan. Baseline O2- levels were 21.0±5.8 in the MS group and 22.115.9 in the controls. Post-CLO the O2- levels declined to 8.210.7 and 7.811.5, both significantly lower than baseline (P< .O2-). These data demonstrate that CLO supplementation reduces the intensity of PMN and monocyte reactions to a standard stimulus as measured by toxic oxygen metabolite production, although the monocyte effects were only observed in a population (MS) with increased baseline activity levels.It has previously been assumed that omega-3 fatty acids might exert antiatherogenic effects via their inhibitory effects on platelet reactions. If leukocytes are important mediators of endothelial damage and/or cholesterol deposition in arterial walls, then our data suggest another mechanism by which fish oil may confer benefit in reducing the risk of arterial disease.
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Wichmann, G., Y. Shao, J. Yu, A. Dietz, and S. Wiegand. "Linkage of human leukocyte antigens, infection with oncogenic viruses, immunodeficiency and head and neck cancer: Differences between Chinese and German populations." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686094.

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Shao, J., and J. Yu. "Linkage of human leukocyte antigens, infection with oncogenic viruses, immunodeficiency and development of head and neck cancer: Differences between Chinese and German populations." In Abstract- und Posterband – 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Digitalisierung in der HNO-Heilkunde. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1686073.

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Lay, John C., and Neil E. Alexis. "Flow Cytometric Differentiation Of Sputum Leukocytes Populations And Subpopulations." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4278.

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Cescon da Rosa, Douglas, ISCIA TERESINHA LOPES CENDES, Tânia K. de Araujo, FERNANDO CENDES, Nancy Watanabe, and FÁBIO R. TORRES. "Analysis of the distribution of alleles of the Human Leukocyte Antigen (HLA) system in Brazilian population." In XXV Congresso de Iniciação Cientifica da Unicamp. Campinas - SP, Brazil: Galoa, 2017. http://dx.doi.org/10.19146/pibic-2017-78836.

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Gomes, Karina, Maria Carvalho, Ramon Pereira, Henrique Guimarães, Antônio Teixeira, Alexandre Braga, Maira Barbosa, Wagner Junior, and Paulo Caramelli. "MACHINE LEARNING-BASED ROUTINE LABORATORY VARIABLES SCREENING FOR ONE-YEAR COGNITIVE AND FUNCTIONAL DECLINE IN INDIVIDUALS AGED 75+ YEARS: THE PIETÀ STUDY." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda004.

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Background: Cognitive and functional decline are important health problems in older adults. Objectives: To investigate Machine Learning (ML) algorithms of routine laboratory variables in predicting cognitive and functional decline in a population-based sample aged 75+ years within one-year. Methods: 132 individuals were selected from a population-based project. Functional and cognitive performances were evaluated at baseline and one year after. Results of routine laboratory tests obtained at baseline were used to generate three ML algorithms. Results: Random forest (RF), including triglycerides, glucose, hematocrit, RDW, albumin, hemoglobin, globulin, HDL, TSH, creatinine, lymphocyte, erythrocyte, platelet/leucocyte (PLR) and neutrophil/leucocyte (NLR) ratios, ALT, leukocyte, LDL, cortisol, GGT and eosinophil, showed the best performance to predict the cognitive decline (accuracy = 0.80). For functional decline (accuracy =0.92), the most important RF variables were platelet, PLR and NLR, hemoglobin, globulin, cortisol, RDW, glucose, basophil, B12 vitamin, creatinine, GGT, ALT, AST, eosinophil, hematocrit, erythrocyte, triglycerides, HDL and monocyte. Conclusions: Our results suggest that ML presents a good accuracy to predict cognitive and functional decline in oldest-old subjects using routine laboratory variables.
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Mazurova, A. A., and K. M. Shpadaruk. "EVALUATION OF THE REACTIVITY OF THE ORGANISM DURING COMBINED THERAPY IN PATIENTS WITH TUBERCULOSIS BY CELL PARAMETERS AND BIOCHEMICAL INDICATORS." In SAKHAROV READINGS 2022: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2022. http://dx.doi.org/10.46646/sakh-2022-2-87-90.

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In the course of the study, an assessment was made of the reactivity of the organism of patients suffering from tuberculosis, according to cellular indicators of peripheral blood and integral indices of homeostasis (leukocyte index of intoxication according to Kalf-Kalif (LII), index of the ratio of neutrophils to lymphocytes (NIL), index of the ratio of neutrophils and monocytes (IRNM), the index of the ratio of lymphocytes and eosinophils (IRLE), the index of the ratio of lymphocytes to the erythrocyte sedimentation rate (IRSOE) for therapy.As a result of the study, we found that during therapy in patients with tuberculosis, the erythrocyte population is the most sensitive parameters to the treatment. Also, the most sensitive and highly informative are integral indicators: the index of the ratio of neutrophils to lymphocytes, the index of the ratio of lymphocytes and eosinophils and the index of the ratio of neutrophils and monocytes.
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Reports on the topic "Leukocyte populations"

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Glaser, Sally L. Human Leukocyte Antigen (HLA) Genotype as a Contributor to Racial/Ethnic Differences in Breast Cancer: A Population-Based, Molecular Epidemiologic Study. Fort Belvoir, VA: Defense Technical Information Center, July 2005. http://dx.doi.org/10.21236/ada441312.

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Glaser, Sally, Esther M. John, Christina A. Clarke, and Henry A. Erlich. Human Leukocyte Antigen (HLA) Genotype as a Contributor to Racial/Ethnic Differences in Breast Cancer: A Population-Based, Molecular Epidemiologic Study. Fort Belvoir, VA: Defense Technical Information Center, July 2004. http://dx.doi.org/10.21236/ada428463.

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