Dissertations / Theses on the topic 'Least work'

This study evaluates the construct validity of the Least Preferred Co-worker (LPC) Scale by testing the predictions made by the motivational hierarchy hypothesis. The respondents were one hundred fifty-nine supervisors and managers. The LPC determined leadership style as either relationship-oriented or task-oriented. Situational control was measured by the Leader-Member Relations scale, Task Structure scale, and Position Power scale. Consideration behavior, measured by the adapted LBDQ, reflected a need for interpersonal success. Initiation of structure behaviors, measured by the adapted LBDQ, reflected a need for task success. Two hypotheses were tested: (1) High LPC leaders in high control situations engage in more task-oriented behaviors than high LPC leaders in low control situations. Low LPC leaders' task-oriented behaviors are consistent across situational control. (2) Low LPC leaders in high control situations engage in more consideration behaviors than low LPC leaders in low control situations. High LPC leaders' consideration behaviors are consistent across situational control. The results of this study supplements previous research (Green, Nebeker & Boni, 1976; Michaelson, 1973) supportive of the motivational hierarchy inteipretation of the LPC. Hypothesis 1 was not supported. However, a significant interaction effect supported Hypothesis 2. Criticisms concerning the construct validity of the LPC, the motivational hierarchy inteipretation of the LPC, and the Contingency Model of Leadership Effectiveness are discussed. Several recommendations for future research are suggested.

Assessment tools have been used for various purposes, including for protecting children from maltreatment. The main aim of this study was to to evaluate and determine the relevance of the Family Assessment for Leased Developed Countries (FALDC) assessment tool for child protection services in the Eastern Cape Province. The research was conducted using the social developmental welfare approach (Patel, 2005) and ecological systems theory (Healy, 2005). The study made use of the qualitative research method; in doing so the study made use of the case study design. In using the qualitative research method, focus group discussions were conducted with 29 social workers involved in child protection services. The findings of the study indicated that the FALDC assessment tool provides information useful for child protection services even though it contains sections that are regarded as less relevant to child protection. The study also founded that the FALDC assessment tool is relevant to child protection in the South African context, yet it needs to be aligned so that it provides much of the information desired by those involved in child protection. A conclusion drawn from this study is that the FALDC assessment tool appears to be relevant for child protection services. The FALDC assessment tool needs to be adjusted taking into consideration other aspects important to child protection in the South African child protection context.

This research synthesizes data and presents it using mapping software to help to identify potential site locations for community-centered higher education alternatives and more traditional junior-level colleges in Uganda. What factors can be used to quantify one site over another for the location of such an institution and if these factors can be isolated; why should they be used by local authorities? the variables are secured from the Southern and Eastern Africa Consortium for Monitoring Educational Quality (SACMEQ), Afrobarometer, census data, as well as technology reports and surveys. These variables are reduced, grouped and mapped to help determine the best location for a junior-level college. the use of local expert opinion on geopolitical, economic, and educational situations can be interfaced with the database data to identify potential sites for junior-level colleges with the potential to reduce the failure rate of such post-secondary school ventures. These data are analyzed in the context of reported higher education policies and outcomes from the national ministries, United Nations Educational, Scientific and Cultural Organization (UNESCO), quality assurances agencies in the region, the World Bank, and national datasets. the final product is a model and tool that can be used by local experts to better select future sites to expand higher education, especially in rural areas in the least developed countries.

De nombreux constats contemporains s’alarment du malaise récurrent des ressources humaines hospitalières, particulièrement à l’endroit des médecins et des soignants, et par conséquent du risque de mauvaise qualité de prise en charge des patients. Adoptant une approche plus optimiste, des chercheurs américains en soins infirmiers ont mis en évidence depuis le début des années 1980 l’existence d’hôpitaux dits magnétiques, parce qu’attractifs et fidélisateurs, et où il ferait bon travailler et se faire soigner. Cette thèse vise à approfondir le concept de Magnet Hospital, à éclairer sa définition et sa portée pour la gestion des ressources humaines hospitalières en France. Suivant une démarche hypothético-déductive, la conceptualisation, fondée sur un état de l’art, débute par une appropriation du modèle synthétique du Magnet Hospital. Empruntant une perspective psychosociale, notre modèle original de recherche se focalise sur la perception, à l’échelle des unités de soins, des attributs managériaux du magnétisme hospitalier (leadership transformationnel, empowerment perçu de la participation et climat relationnel collégial entre médecins et soignants) et ses conséquences attitudinales positives (satisfaction, implication, intention de rester, équilibre émotionnel travail/hors travail et efficacité collective perçue). Une méthodologie quantitative interroge au moyen de 8 échelles ad hoc un échantillon représentatif de 133 médecins, 361 infirmières et 362 aides-soignantes de 36 services de médecine polyvalente français. Une série de modélisations par équations structurelles, selon l’algorithme Partial Least Squares, teste la nature et l’intensité des relations directes et indirectes du magnétisme managérial perçu. Les résultats statistiques indiquent une bonne qualité des construits et d’ajustement des modèles. Un contexte managérial magnétique produit son principal effet positif sur l’efficacité collective perçue. Des différences catégorielles existent quant à la perception de sa composition et à la transmission de ses effets par la médiation de l’efficacité collective perçue, signalant le caractère contingent du magnétisme. Ces résultats ouvrent des perspectives managériales et scientifiques, en soulignant l’intérêt des approches positives de l’organisation hospitalière
Many contemporary findings are alarmed of the recurring discomfort of hospital human resources, especially against doctors and nurses, and consequently against risk of poor quality of care for patients. Adopting a more optimistic approach, American nursing scholars have highlighted since the 1980s, some magnet hospitals, able to attract and retain, and with good working and care conditions. This thesis aims to explore Magnet Hospital concept, to inform its definition and scope for hospital human resource management in France. According to a hypothetico-deductive approach, based on a review of the literature, the conceptualization begins with appropriation of synthetic Magnet Hospital model. Under a psychosocial perspective, our original research model focuses on perception of managerial magnetic attributes (transformational leadership, perceived empowerment of participation, collegial climate between doctors and nurses) and their consequences on positive job attitudes (satisfaction, commitment, intent to rest, emotional equilibrium work/family, perceived collective efficacy), at wards level. A quantitative methodology proceeds by a questionnaire of 8 ad hoc scales and interviews 133 doctors, 361 nurses, 362, auxiliary nurses, in 36 French medicine units. A set of structural equations modeling, according to Partial Least Squares, tests nature and intensity of direct and indirect relationships of perceived managerial magnetism. The statistical results show a good validity of constructs and a good fit of models. The major positive effect of magnetic managerial context is on perceived collective efficacy. Some professional differences exist about perceptions of composition and transmission of magnetic effects (via mediation of perceived collective efficacy), indicating the contingency of magnetism. These findings open managerial and scientific opportunities, emphasizing the interest for positive organizational approach of hospital

We study nonlinear least-squares problem that can be transformed to linear problem by change of variables. We derive a general formula for the statistically optimal weights and prove that the resulting linear regression gives an optimal estimate (which satisfies an analogue of the Rao–Cramer lower bound) in the limit of small noise.

In 1935 the linguist George Kingsley Zipf made a now classic observation about the relationship between a word's length and its frequency: the more frequent a word is, the shorter it tends to be. He claimed that this 'Law of Abbreviation' is a universal structural property of language. The Law of Abbreviation has since been documented in a wide range of human languages, and extended to animal communication systems and even computer programming languages. Zipf hypothesised that this universal design feature arises as a result of individuals optimising form-meaning mappings under competing pressures to communicate accurately but also efficiently - his famous Principle of Least Effort. In this thesis, I present a novel set of studies which provide direct experimental evidence for this explanatory hypothesis. Using a miniature artificial language learning paradigm, I show in Chapter 2 that language users optimise form-meaning mappings in line with the Law of Abbreviation only when pressures for accuracy and efficiency both operate during a communicative task. These results are robust across different methods of data collection: one version of the experiment was run in the lab, and another was run online, using a novel method I developed which allows participants to partake in dyadic interaction through a web-based interface. In Chapter 3, I address the growing body of work suggesting that a word's predictability in context may be an even stronger determiner of its length than its frequency alone. For instance, Piantadosi et al. (2011) show that shorter words have a lower average surprisal (i.e., tend to appear in more predictive contexts) than longer words, in synchronic corpora across many languages. We hypothesise that the same communicative pressures posited by the Principle of Least Effort, when acting on speakers in situations where context manipulates the information content of words, can give rise to these lexical distributions. Adapting the methodology developed in Chapter 2, I show that participants use shorter words in more predictive contexts only when subject to the competing pressures for accurate and efficient communication. In a second experiment, I show that participants are more likely to use shorter words for meanings with a lower average surprisal. These results suggest that communicative pressures acting on individuals during language use can lead to the re-mapping of a lexicon to align with 'Uniform Information Density', the principle that information content ought to be evenly spread across an utterance, such that shorter linguistic units carry less information than longer ones. Over generations, linguistic behaviour such as that observed in the experiments reported here may bring entire lexicons into alignment with the Law of Abbreviation and Uniform Information Density. For this to happen, a diachronic process which leads to permanent lexical change is necessary. However, crucial evidence for this process - decreasing word length as a result of increasing frequency over time - has never before been systematically documented in natural language. In Chapter 4, I conduct the first large-scale diachronic corpus study investigating the relationship between word length and frequency over time, using the Google Books Ngrams corpus and three different word lists covering both English and French. Focusing on words which have both long and short variants (e.g., info/information), I show that the frequency of a word lemma may influence the rate at which the shorter variant gains in popularity. This suggests that the lexicon as a whole may indeed be gradually evolving towards greater efficiency. Taken together, the behavioural and corpus-based evidence presented in this thesis supports the hypothesis that communicative pressures acting on language-users are at least partially responsible for the frequency-length and surprisal-length relationships found universally across lexicons. More generally, the approach taken in this thesis promotes a view of language as, among other things, an evolving, efficient code for information transfer.

Poor health and injury represent major obstacles to the future economic security of Australia. The national economic cost of work-related injury is estimated at $57.5 billion p/a. Since exposure to high physical demands is a major risk factor for musculoskeletal injury, monitoring and managing such physical activity levels in workers is a potentially important injury prevention strategy. Current injury monitoring practices are inadequate for the provision of clinically valuable information about the tissue specific responses to physical exertion. Injury of various soft tissue structures can manifest over time through accumulation of micro-trauma. Such micro-trauma has a propensity to increase the risk of acute injuries to soft-tissue structures such as muscle or tendon. As such, the capacity to monitor biomarkers that result from the disruption of these tissues offers a means of assisting the pre-emptive management of subclinical injury prior to acute failure or for evaluation of recovery processes. Here we have adopted an in-vivo exercise induced muscle damage model allowing the application of laboratory controlled conditions to assist in uncovering biochemical indicators associated with soft-tissue trauma and recovery. Importantly, urine was utilised as the diagnostic medium since it is non-invasive to collect, more acceptable to workers and less costly to employers. Moreover, it is our hypothesis that exercise induced tissue degradation products enter the circulation and are subsequently filtered by the kidney and pass through to the urine. To test this hypothesis a range of metabolomic and proteomic discovery-phase techniques were used, along with targeted approaches. Several small molecules relating to tissue damage were identified along with a series of skeletal muscle-specific protein fragments resulting from exercise induced soft-tissue damage. Each of the potential biomolecular markers appeared to be temporally present within urine. Moreover, the regulation of abundance seemed to be associated with functional recovery following the injury. This discovery may have important clinical applications for monitoring of a variety of inflammatory myopathies as well as novel applications in monitoring of the musculoskeletal health status of workers, professional athletes and/or military personnel to reduce the onset of potentially debilitating musculoskeletal injuries within these professions.

Using best-practices and supports that apply the least dangerous assumption (LDA) is a powerful tool for increasing overall student quality of life and keeping alive a vision of high achievement for all students. This presentation will focus on research and evidence based strategies to promote the LDA for students with significant disabilities regarding accessing personally relevant academic instruction with meaningful student centered outcomes. OBJECTIVES: By the end of this session, participants will be able to: a) identify four criteria to promote Least Dangerous Assumption b) discuss ways to successfully implement the four criteria in their classroom to meet the needs of a wide range of diverse students with significant disabilities c) identify resources that incorporate these four criteria and are applicable to students from diverse backgrounds

The aim of this thesis is to identify factors that affect the university students&rsquo
acceptance of multi-purpose Smart Cards. The findings of this study will be beneficial to facilitate the use of Smart-Card enabled system both n universities and in other institutions which either have these systems in use or plan to invest on these systems in the future. The research methodology employed within this study is based on quantitative methods. A survey instrument comprising 51 5-point Likert-type questions has been developed and applied to 207 university Middle East Technical University students. The data collected has been analyzed using Exploratory Factor Analysis to categorize factors having items. According to analysis results, the data classified under 5 factors
Perceived Usefulness, Perceived Ease of Use, Behavioral Intention, Anxiety, and Technological Complexity. Then, the relations between these 5 factors identified and a measurement model was created. For assessing the proposed model Discriminant and Convergent Validity scores were calculated by Confirmatory Factor Analysis. Then, Structural Equation Modeling was conducted with Partial Least Squares for validating the model&rsquo
s estimated influence. The study has shown that the main Technology Acceptance Model constructs fit for determining the university students&rsquo
intention of Smart Card usage except for Perceived Ease of Use over Behavioral Intention. Moreover, study showed that Anxiety and Technological Complexity were the external factors that have effect on willingness of using multi-purpose Smart Cards. If students have Anxiety, this affects their perception of easiness of the system and it has negative indirect effect on the perceived usefulness and direct effect on intention. Technological Complexity is another factor which has direct affect on the perception of easiness and usefulness and intention.

In this thesis, identification of periodically varying orders of univariate Periodic Autoregressive Moving-Average (PARMA) processes is mainly studied. The identification of the varying orders of PARMA process is carried out by generalizing the well-known Box-Jenkins techniques to a seasonwise manner. The identification of pure periodic moving-average (PMA) and pure periodic autoregressive (PAR) models are considered only. For PARMA model identification, the Periodic Autocorrelation Function (PeACF) and Periodic Partial Autocorrelation Function (PePACF), which play the same role as their ARMA counterparts, are employed. For parameter estimation, which is considered only to refine model identification, the conditional least squares estimation (LSE) method is used which is applicable to PAR models. Estimation becomes very complicated, difficult and may give unsatisfactory results when a moving-average (MA) component exists in the model. On account of overcoming this difficulty, seasons following PMA processes are tried to be modeled as PAR processes with reasonable orders in order to employ LSE. Diagnostic checking, through residuals of the fitted model, is also performed stating its reasons and methods. The last part of the study demonstrates application of identification techniques through analysis of two seasonal hydrologic time series, which consist of average monthly streamflows. For this purpose, computer programs were developed specially for PARMA model identification.

In this research, it was mainly aimed to develop an acceptance model for processes, namely the process acceptance model (PAM). For this purpose, a questionnaire, comprising 3-part and 81-question, was developed to collect quantitative and qualitative data from people having relationships with certain process-focused models and/or standards (CMMI, ISO 15504, ISO 9001, ISO 27001, AQAP-160, AQAP-2110, and/or AS 9100). To revise and refine the questionnaire, expert reviews were ensured, and a pilot study was conducted with 60 usable responses. After reviews, refinements and piloting, the questionnaire was deployed to collect data and in-total 368 usable responses were collected from the people. Here, collected data were screened concerning incorrectly entered data, missing data, outliers and normality, and reliability and validity of the questionnaire were ensured. Partial least squares structural equation modeling (PLS SEM) was applied to develop the PAM. In this context, exploratory and confirmatory factor analyses were applied, and the initial model was estimated and evaluated. The initial model was modified as required by PLS SEM, and confirmatory factor analysis was repeated, and the modified final model was estimated and evaluated. Consequently, the PAM, with 18 factors and their statistically significant relationships, was developed. Furthermore, descriptive statistics and t-tests were applied to discover some interesting, meaningful, and important points to be taken into account regarding the acceptance of processes. Moreover, collected quantitative data were analyzed, and three additional factors were discovered regarding the acceptance of processes. Besides, a checklist to test and/or promote the acceptance of processes was established.

The following study was conducted at an upper secondary school in Sweden and attempts to explore the question of what influences male pupils’ reading habits. Many quantitative international studies, including PISA, PIRLS and IEA Reading Literacy, have sought to answer this question, but only partially succeeded due to the limitations of their methods. Therefore, this study seeks to explore this question in more depth using qualitative methods, including interviews and classroom observations, but also minor tests. Two facts which the previously mentioned international studies have found is that boys and particularly immigrant boys tend to have worse reading results than their counterparts. It is therefore the aim of this study to study four male students in upper secondary school; of which two are native Swedes and the other two are unaccompanied refugee children; one from Afghanistan and the other from Morocco. The findings of this study are as follows. Firstly, necessity was found to be the single most important factor for the reading habits of these four pupils; especially the two refugees. Both refugees learnt to read under harsh circumstances in madrassas in their respective home countries. Moreover, the Moroccan pupil learnt to speak and read Spanish fluently during his seven years as a homeless child. Furthermore, in the absence of necessity, interest was found to be decisive in determining the pupils’ reading habits. In addition to this, the study theorizes that an interest in reading generally arises before the ability to read and not vice versa. However, teachers can in fact affect their pupils’ reading habits even in upper secondary school.

O Vírus da Imunodeficiência Humana (HIV) é o agente etiológico da Síndrome da Imunodeficiência Adquirida (AIDS). A AIDS é uma doença de distribuição mundial, e estima-se que existam atualmente pelo menos 36,9 milhões de pessoas infectadas com o vírus. Durante o seu ciclo replicativo, o HIV promove diversas alterações na fisiologia da célula hospedeira a fim de promover sua sobrevivência e potencializar a replicação. A rápida progressão da infecção pelo HIV-1 em humanos e em modelos animais está intimamente ligada à função da proteína acessória Nef. Dentre as diversas ações de Nef está a regulação negativa de proteínas importantes na resposta imunológica, como o receptor CD4. Sabe-se que esta ação resulta da indução da degradação de CD4 em lisossomos, mas os mecanismos moleculares envolvidos ainda são totalmente elucidados. Nef forma um complexo tripartite com a cauda citosólica de CD4 e a proteína adaptadora 2 (AP-2), em vesículas revestidas por clatrina nascentes, induzindo a internalização e degradação lisossomal de CD4. Pesquisas anteriores demonstraram que o direcionamento de CD4 aos lisossomos por Nef envolve a entrada do receptor na via dos corpos multivesiculares (MVBs), por um mecanismo atípico, pois, embora não necessite da ubiquitinação de carga, depende da ação de proteínas que compõem os ESCRTs (Endosomal Sorting Complexes Required for Transport) e da ação de Alix, uma proteína acessória da maquinaria ESCRT. Já foi reportado que Nef interage com subunidades dos complexos AP-1, AP-2, AP-3 e Nef não parece interagir com subunidades de AP-4 e AP-5. Entretanto, o papel da interação de Nef com AP-1 e AP-3 na regulação negativa de CD4 ainda não está totalmente elucidado. Ademais, AP-1, AP-2 e AP-3 são potencialmente heterogêneos devido à existência de isoformas múltiplas das subunidades codificadas por diferentes genes. Todavia, existem poucos estudos para demonstrar se as diferentes combinações de isoformas dos APs são formadas e se possuem propriedades funcionais distintas. O presente trabalho procurou identificar e caracterizar fatores celulares envolvidos na regulação do tráfego intracelular de proteínas no processo de regulação negativa de CD4 induzido por Nef. Mais especificamente, este estudo buscou caracterizar a participação do complexo AP-1 na modulação negativa de CD4 por Nef de HIV-1, através do estudo funcional das duas isoformas de ?-adaptina, subunidades de AP-1. Utilizando a técnica de Pull-down demonstramos que Nef é capaz de interagir com ?2. Além disso, nossos dados de Imunoblot indicaram que a proteína ?2-adaptina, e não ?1-adaptina, é necessária no processo de degradação lisossomal de CD4 por Nef e que esta participação é conservada para degradação de CD4 por Nef de diferentes cepas virais. Ademais, por citometria de fluxo, o silenciamento de ?2, e não de ?1, compromete a diminuição dos níveis de CD4 por Nef da membrana plasmática. A análise por imunofluorêsncia indireta também revelou que a diminuição dos níveis de ?2 impede a redistribuição de CD4 por Nef para regiões perinucleares, acarretando no acúmulo de CD4, retirados por Nef da membrana plasmática, em endossomos primários. A depleção de ?1A, outra subunidade de AP-1, acarretou na diminuição dos níveis celulares de ?2 e ?1, bem como, no comprometimento da eficiente degradação de CD4 por Nef. Além disso, foi possível observar que, ao perturbar a maquinaria ESCRT via super-expressão de HRS (uma subunidade do complexo ESCRT-0), ocorreu um acumulo de ?2 em endossomos dilatados contendo HRS-GFP, nos quais também detectou-se CD4 que foi internalizado por Nef. Em conjunto, os resultados indicam que ?2-adaptina é uma importante molécula para o direcionamento de CD4 por Nef para a via ESCRT/MVB, mostrando ser uma proteína relevante no sistema endo-lisossomal. Ademais, os resultados indicaram que as isoformas ?-adaptinas não só possuem funções distintas, mas também parecem compor complexos AP-1 com diferentes funções celulares, já que apenas a variante AP-1 contendo ?2, mas não ?1, participa da regulação negativa de CD4 por Nef. Estes estudos contribuem para o melhor entendimento dos mecanismos moleculares envolvidos na atividade de Nef, que poderão também ajudar na melhor compreensão da patogênese do HIV e da síndrome relacionada. Em adição, este trabalho contribui para o entendimento de processos fundamentais da regulação do tráfego de proteínas transmembrana no sistema endo-lisossomal.
The Human Immunodeficiency Virus (HIV) is the etiologic agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a disease which has a global distribution, and it is estimated that there are currently at least 36.9 million people infected with the virus. During the replication cycle, HIV promotes several changes in the physiology of the host cell to promote their survival and enhance replication. The fast progression of HIV-1 in humans and animal models is closely linked to the function of an accessory protein Nef. Among several actions of Nef, one is the most important is the down-regulation of proteins from the immune response, such as the CD4 receptor. It is known that this action causes CD4 degradation in lysosome, but the molecular mechanisms are still incompletely understood. Nef forms a tripartite complex with the cytosolic tail of the CD4 and adapter protein 2 (AP-2) in clathrin-coated vesicles, inducing CD4 internalization and lysosome degradation. Previous research has demonstrated that CD4 target to lysosomes by Nef involves targeting of this receptor to multivesicular bodies (MVBs) pathway by an atypical mechanism because, although not need charging ubiquitination, depends on the proteins from ESCRTs (Endosomal Sorting Complexes Required for Transport) machinery and the action of Alix, an accessory protein ESCRT machinery. It has been reported that Nef interacts with subunits of AP- 1, AP-2, AP-3 complexes and Nef does not appear to interact with AP-4 and AP-5 subunits. However, the role of Nef interaction with AP-1 or AP-3 in CD4 down-regulation is poorly understood. Furthermore, AP-1, AP-2 and AP-3 are potentially heterogeneous due to the existence of multiple subunits isoforms encoded by different genes. However, there are few studies to demonstrate if the different combinations of APs isoforms are form and if they have distinct functional properties. This study aim to identify and characterize cellular factors involved on CD4 down-modulation induced by Nef from HIV-1. More specifically, this study aimed to characterize the involvement of AP-1 complex in the down-regulation of CD4 by Nef HIV-1 through the functional study of the two isoforms of ?-adaptins, AP-1 subunits. By pull-down technique, we showed that Nef is able to interact with ?2. In addition, our data from immunoblots indicated that ?2- adaptin, not ?1-adaptin, is required in Nef-mediated targeting of CD4 to lysosomes and the ?2 participation in this process is conserved by Nef from different viral strains. Furthermore, by flow cytometry assay, ?2 depletion, but not ?1 depletion, compromises the reduction of surface CD4 levels induced by Nef. Immunofluorescence microscopy analysis also revealed that ?2 depletion impairs the redistribution of CD4 by Nef to juxtanuclear region, resulting in CD4 accumulation in primary endosomes. Knockdown of ?1A, another subunit of AP-1, resulted in decreased cellular levels of ?1 and ?2 and, compromising the efficient CD4 degradation by Nef. Moreover, upon artificially stabilizing ESCRT-I in early endosomes, via overexpression of HRS, internalized CD4 accumulates in enlarged HRS-GFP positive endosomes, where co-localize with ?2. Together, the results indicate that ?2-adaptin is a molecule that is essential for CD4 targeting by Nef to ESCRT/MVB pathway, being an important protein in the endo-lysosomal system. Furthermore, the results indicate that ?-adaptins isoforms not only have different functions, but also seem to compose AP-1 complex with distinct cell functions, and only the AP-1 variant comprising ?2, but not ?1, acts in the CD4 down-regulation induced by Nef. These studies contribute to a better understanding on the molecular mechanisms involved in Nef activities, which may also help to improve the understanding of the HIV pathogenesis and the related syndrome. In addition, this work contributes with the understanding of primordial process regulation on intracellular trafficking of transmembrane proteins.

碩士
國立成功大學
土木工程學系
106
In this thesis, the Moving Least Work (MLW) method is used to model the mechanical behaviors of Mindlin Plates. This method uses the Moving Least Work approach to establish approximating functions. In the weight-residual problem precess, the residual value is multiplied by the weight function and multiplied by the conjugate residual value, so that it contains the conception of the least work. Finally we used the point collocation method to get the solutions of displacement fields and stress resultant fields. The simply supported Mindlin plate is modeled under the sinusoidal load, and the boundary-value problems are solved by polynomial-analytic solutions. Using different basis functions and changing the numbers of the uniform-distributed points, we compared the numerical solutions with analytic solutions to validate the feasibility and convergence of the present method.

Recent advances in travel demand modeling have concentrated on adding behavioral realism by focusing on an individual’s activity participation. And, to account for trip-chaining, tour-based methods are largely replacing trip-based methods. Alongside these advances and innovations in dynamic traffic assignment (DTA) techniques, however, time-of-day (TOD) modeling remains an Achilles’ heel. As congestion worsens and operators turn to variable road pricing, sensors are added to networks, cell phones are GPS-enabled, and DTA techniques become practical, accurate time-of-day forecasts become critical. In addition, most models highlight tradeoffs between travel time and cost, while neglecting variations in travel time. Research into stated and revealed choices suggests that travel time variability can be highly consequential. This dissertation introduces a method for imputing travel time variability information as a continuous function of time-of-day, while utilizing an existing method for imputing average travel times (by TOD). The methods employ ordinary least squares (OLS) regression techniques, and rely on reported travel time information from survey data (typically available to researchers), as well as travel time and distance estimates by origin-destination (OD) pair for free-flow and peak-period conditions from network data. This dissertation also develops two models of activity timing that recognize the imputed average travel times and travel time variability. Both models are based in random utility theory and both recognize potential correlations across time-of-day alternatives. In addition, both models are estimated in a Bayesian framework using Gibbs sampling and Metropolis-Hastings (MH) algorithms, and model estimation relies on San Francisco Bay Area data collected in 2000. The first model is the continuous cross-nested logit (CCNL) and represents tour outbound departure time choice in a continuous context (rather than discretizing time) over an entire day. The model is formulated as a generalization of the discrete cross-nested logit (CNL) for continuous choice and represents the first random utility maximization model to incorporate the ability to capture correlations across alternatives in a continuous choice context. The model is then compared to the continuous logit, which represents a generalization of the multinomial logit (MNL) for continuous choice. Empirical results suggest that the CCNL out-performs the continuous logit in terms of predictive accuracy and reasonableness of predictions for three tolling policy simulations. Moreover, while this dissertation focuses on time-of-day modeling, the CCNL could be used in a number of other continuous choice contexts (e.g., location/destination, vehicle usage, trip durations, and profit-maximizing production). The second model is a bivariate multinomial probit (BVMNP) model. While the model relies on discretization of time (into 30-minute intervals), it captures both key dimensions of a tour’s timing (rather than just one, as in this dissertation’s application of the CCNL model), which is important for tour- and activity-based models of travel demand. The BVMNP’s ability to capture correlations across scheduling alternatives is something no existing two-dimensional choice models of tour timing can claim. Both models represent substantial contributions for continuous choice modeling in transportation, business, biology, and various other fields. In addition, the empirical results of the models evaluated here enhance our understanding of individuals’ time-of-day decisions. For instance, average travel time and its variance are estimated to have a negative effect on workers’ utilities, as expected, but are not found to be that practically relevant here, probably because most workers are rather constrained in their activity scheduling and/or work hours. However, correlations are found to be rather strong in both models, particularly for home-to-work journeys, suggesting that if models fail to accommodate such correlations, biased application results may emerge.
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碩士
國立交通大學
工學院工程技術與管理學程
99
Conventionally, the additional clause of request of change design is one of clauses in engineering contract and noticeably appoints that ask of design change during the effecting period of contract due to occurring of uncertain conditions or the inquire of owns. Two sides of contract have to follow established procedures to alter the corresponding contains of the contract. Reward and time-limit of the project are often two major factors in engineering contracts and may construct significant influence, unfair for both sides, and continual dispute when a request of change design rises. This study first revised what are engineering contracts, the properties as well as types of the engineering contracts, and the contains of contract about the provisions of change design based on literatures compilation and analysis. Also, a question nail was create and answered by corresponding construction engineers to conclude the argument types for request of change design in public work. Among most normally argument types in Taiwan, this study focused on investigation the causes as well as seeking corresponding solutions for the issue of altering of working items and qualities in contract. Finally, the study concluded five major disputes in engineering contract: change design, giving explanation, delay in claimant, check and accept, and engineering warranty. Among these five arguments, request of change design was the most dispute issue and altering of working items and qualities were the most important factors. Finally, the study recommended that the issues can be solved via reducing request of change design, concluding a practicable specification for change design, and adjusting the rate of risk-sharing between both sides of contract.

碩士
國立臺中教育大學
教師專業碩士學位學程
106
The purpose of this study was to explore fifth-grade low-achievers performances on solving word problems of the greatest common divisor [gcd] and the least common multiple [lcm. The participants were twenty-six 5th graders from one elementary school at New Taipei City. Self-constructed pater-and-pencil test was given. In addition, three students were selected for semi-structured interviews based on their responses of the test. The results were as follows: 1. The differences between the correct rate of the gcd and the lcm of the low-achievers and the average of the whole class were greater than the difference between other concept. Low-achievers performed better on the basic calculation problems on the gcd and the lcm compared to the word problems. 2. Varied problem-solving methods were used by the 5th-grade low-achievers. In the gcd word problems, low-achievers might be able to: figure out correct divisor of two numbers and chose the correctly gdc; find correct divisor of two numbers and chose correctly common divisors; figure out correct divisor of two numbers but could not write all the common divisors of two numbers; find correct divisor of two numbers. In the lcm word problems, even though some participants were aboe to solve the problem correctly, the others were confused between gcd and lcm, and list all divisors of two numbers and find their common divisor(s). 3. Mistakes of low-achievers’ thinking on solving gcd and lcm word problems of included: calculation without understanding the meaning of the question, and ignore the important information of the context. 4. There were three common factors influencing low-achievers’ problem-solving: they couldn’t understand the words of the problem; they did not recheck their answers due to spending too much time writing the exam; the problem descriptions were different from the textbook.

Dissertação de mestrado em Direito dos Contratos e da Empresa
O contrato de arrendamento urbano é um dos contratos mais utilizado pela população ao longo de toda a sua vida. No entanto, existem situações relativas a este tipo de contratos que ainda não foram devidamente esclarecidas pelo ordenamento jurídico português, como é o caso de saber sobre quem recai a obrigação de realizar obras no imóvel que é objeto do contrato de arrendamento e os direitos que assistem a ambas as partes contratuais nestas situações. Compreendendo as dificuldades que todas as alterações jurídicas que têm vindo a ser aplicadas no seio do arrendamento urbano nos poderiam trazer, procuramos realizar o estudo de algumas das questões mais pertinentes acerca da realização de obras em imóvel arrendado, de forma a conseguirmos atingir em que moldes se encontra este assunto no mundo jurídico atual. Para conseguirmos chegar a tal, partimos da análise da obrigação do senhorio proporcionar o gozo do imóvel, analisando as diversas perspetivas doutrinais e jurisprudenciais, bem como a evolução do pensamento de vários autores acerca deste tema. Procuramos assim partir da obrigação principal decorrente do contrato de locação que recai sobre o senhorio de assegurar o gozo do imóvel para os fins a que se destina, para analisar quais as obrigações que daí decorrem para ambas as partes, bem como os direitos que a estas cabem. Ao longo desta análise tivemos ainda, como consequência do estudo do tema, de ter em atenção as alterações legislativas que o arrendamento urbano foi sofrendo até atingir o panorama atual.
The urban lease is one of the contracts most used by the population throughout their life. However, there are situations related to this type of contracts that have not yet been properly clarified by the Portuguese legal system, as is the case of who falls under the obligation to perform works on the property that is the object of the lease and the rights that attend to both contractual parties in these situations. Understanding the difficulties that all the legal changes that have been applied within the urban lease could bring us, we seek to study some of the most pertinent questions about the realization of works in leased property, so that we can achieve in what manner this subject is found in today's legal world. To achieve this, we start from the analysis of the landlord's obligation to provide the enjoyment of the property, analyzing the various doctrinal and jurisprudential perspectives, as well as the evolution of the thinking of various authors on this subject. We therefore seek to take the principal obligation arising out of the landlord's lease agreement to ensure the enjoyment of the property for the purposes for which it is intended, in order to analyze the obligations arising therefrom for both parties, as well as their rights fit. Throughout this analysis we had, as a consequence of the study of the theme, to take into account the legislative changes that the urban lease was suffering until reaching the current panorama.