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Journal articles on the topic 'Learning Enrichment Centre'
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1
Renzulli, Joseph S. "New Directions for the Schoolwide Enrichment Model." Gifted Education International 10, no. 1 (September 1994): 33–36. http://dx.doi.org/10.1177/026142949401000108.
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This article not only proposes new directions for the Schoolwide Enrichment model, it also analyses the processes of real and effective curriculum change. The very act of learning is perceived to be at the centre of the change process. Developing modifications of existing curricula should also provide appropriate content and skills development which allows all students to develop their full potential. The article is based on Dr Renzulli's recent book, Schools for Talent Development: a Practical Plan for Total School Improvement, published in 1994 by Creative Learning Press.
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Houghton, Chris. "Capturing the pupil voice of secondary gifted and talented students who had attended an enrichment programme in their infant school." Gifted Education International 30, no. 1 (April 2, 2013): 33–46. http://dx.doi.org/10.1177/0261429413480421.
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The study was conducted during the Easter holidays of 2010 at Rawmarsh City Learning Centre with 16 students from school years 8 to 11 who had participated, during their infant years, in a gifted and talented Key Stage One Enrichment Cluster. The students represented a wide range of backgrounds, and five were identified as being on the autistic spectrum. The Enrichment Cluster was known as original ways of learning through enrichment technology and socialisation (OWLETS). OWLETS aimed to address the lack of provision for exceptionally able young children, while supporting them in overcoming any weaknesses in relation to socialisation or engagement. The cluster design was inspired by Renzulli’s Schoolwide Enrichment Model. The study investigated the students’ perspective of key features of their experiences at OWLETS and throughout their subsequent education, examining their views on learning and teaching, and was facilitated by the production of a video with student voices spoken by avatars. Findings showed that those with additional special needs preferred primary school and described struggles in secondary; the other 11 students were more positive about secondary education than primary. All the students viewed opportunities for personalised learning and effective teacher–student relationships as key, and they suggested that children who demonstrate exceptional ability benefit from opportunities to socialise and work collaboratively with similarly gifted peers throughout all stages of education. The study indicated that Renzulli’s model, in this simple format, has the potential to enrich a whole-school approach, meeting the needs of all children including the exceptionally able.
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Bryson, Jo. "Engaging in Change: New Mindsets for Today's Dynamic Environment." Alexandria: The Journal of National and International Library and Information Issues 17, no. 3 (December 2005): 157–66. http://dx.doi.org/10.1177/095574900501700306.
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The article describes the changes in skills needed by library and information workers in order to meet the challenges of a rapidly evolving environment. Globalization and new technology have changed customer expectations radically and information services must change in order to meet new needs while maintaining quality of service. The author identifies fourteen new skills and aptitudes required by information managers if their services are to maintain their relevance in the world of mobile communications and the Internet. These include the ability to share their vision of how a service will operate in the future, to build an organization that embraces change, and to put the customer at the centre of service development. Only by learning and implementing these skills can managers ensure that information services make the most of the unprecedented opportunities for innovation and enrichment of the quality of life that technology provides.
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Khan, Smita. "Research-Practice Liaison in the Asian Scenario." Asian Journal of Behavioural Studies 1, no. 2 (July 1, 2016): 23. http://dx.doi.org/10.21834/ajbes.v1i2.30.
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This keynote paper examines the position of global south in world scenario and calls attention to the urgent need of a responsive architecture to counter the negativities and callousness that is seeping into the built developments due to rapid economic growth. It discusses the nature of a responsive self-practice & observations of a recent research on learning environments, with focus on environ-behavior studies. It discusses the dire need of vital enrichment of policy and practice. The paper makes a case for E-B studies by exposing new challenges, nascent fields and the need to fine tune application of local and traditional learning enriched through people’s experience and feedback in the Asian context.2398-4295 © 2016. The Authors. Published for AMER ABRA by e-International Publishing House, Ltd., UK.. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.Keywords: Global south; E-B studies; challenges; responsive practice & research
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Anam, Khaerul, Raden Sudarwo, and Gunawan Wiradharma. "Sistem Pendidikan Jarak Jauh Berbasis e-Learning Pada Mata Kuliah Pendidikan Matematika I: Studi Kasus di Universitas Terbuka." JARTIKA Jurnal Riset Teknologi dan Inovasi Pendidikan 3, no. 2 (July 11, 2020): 388–95. http://dx.doi.org/10.36765/jartika.v3i2.276.
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Penelitian ini bertujuan untuk mengetahui bagaimana penerapan tutorial online berbasis e-learning dalam sistem pendidikan jarak jauh pada mata kuliah Pendidikan Matematika 1 di Universitas Terbuka. Penerapan yang dimaksud di sini adalah bagaimana perencanaan, pelaksanaan, evaluasi, serta apa saja kendala yang dihadapi selama kegiatan tersebut. Metode penelitian yang digunakan dalam penelitian ini adalah menggunakan metode deskriptif kualitatif dengan pendekatan studi kasus. Hasilnya penelitian ini menunjukkan bahwa (1) Perencanaan Tutorial di sediakan langsung dari UT pusat, tutor tinggal melaksanakan; (2) Pelaksanaan tutorial dimulai dengan membuat video sapaan pada setiap inisiasi, kemudian memantau dan menanggapi dari pertanyaan atau tanggapan mahasiswa terhadap diskusi atau permasalahan yang disajikan, selanjutnya memeriksa dan memeberikan feedback terhadap tugas-tugas mahasiswa pada pertemuan ke 3, 5 dan 7; (3) Evaluasi dilihat dari kehadiran sebesar 20%, keaktifan mahasiswa dalam diskusi 30% dan tugas tutorial sebesar 50%. Nilai tutorial online akan berkontribusi jika nilai Ujian Akhir Semester lebih dari 30%; (4) Kendala yang dialami yaitu keterbatasan akses, tutor maupun mahasiswa masih kurang aktif, penulisan simbol-simbol Matematika.
Abstract: Distance Education System Based E-learning in Mathematics Education I) This study aims to find out how to apply e-learning-based online tutorials in the distance education system in Mathematics Education 1 course at Universitas Terbuka. The application referred in this study is the planning, implementation, evaluation, and the constraints encountered during the activity. The research method used in this study is the qualitative method with a case study approach.The results of this study indicate that (1)The planning is provided directly from the UT centre, the tutor only have to carry out the plan; (2)The tutoring begins by making a greeting video at each initiation, then monitoring and responding students' questions or responses on the discussions or issues presented, providing enrichment, then examining student assignments at the 3rd, 5th and 7th meeting; (3)Evaluation is seen from the attendance by 20%, the activeness of students in discussions by 30% and tutorial assignments by 50%. The value of online tutorials will contribute if the value of the Final Semester Examination is more than 30%; (4)The constraints experienced are as follows: The access is limited, the tutors and students are still less active, Mathematical symbols writing, the RAT SAT is not in accordance with the assignments or material in online tutorial activities.
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Abaza, Mona. "Some Research Notes on Living Conditions and Perceptions Among Indonesian Students in Cairo." Journal of Southeast Asian Studies 22, no. 2 (September 1991): 347–60. http://dx.doi.org/10.1017/s0022463400003921.
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In recent years, North-South patterns of domination and neo-colonialism have occupied the field of social studies. One can argue that theories of modernization such as Lerner's The Passing of Traditional Society bear a certain similarity with dependency theories. Although these later writers formed their theories as a critique of modernizing theories, both perspectives are similar in that they analyze “traditional” or underdeveloped societies from a North-South point of view. Thus, if modernizing theories were criticized by neo-Marxists and Marxists alike as “ethnocentric” because they ignored non-Western types of development and praised Western history as an ideal type and a global model, in the discourse of dependency theories, the North was more than ever present in shaping and influencing the underdevelopment of the South. The impoverishment of the South was analyzed as a direct result of the enrichment of the industrialized North. Although diametrically opposite in ideological aims, these two theoretical perspectives share a common denominator in that they accept the predominance of Western culture and analyze the reaction of the Third World in relation to it. In other words, they both implied that all dynamics originate, and move mainly from the North. This paper will attempt to take a different perspective by looking into the different patterns of exchange on the South-South axis. In analyzing a particular set of networks and cultural exchange which was established through religious scholarship, this paper attempts to follow up Roffs study on “Indonesian and Malay Students in Cairo in the 1920s”. It will shed some light on the significance of al-Azhar in particular, and Cairo in general, as a centre of religious learning which attracts until today students from all over the Muslim world.
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Tay, Juliana, Alissa Salazar, and Hyeseong Lee. "Parental Perceptions of STEM Enrichment for Young Children." Journal for the Education of the Gifted 41, no. 1 (December 14, 2017): 5–23. http://dx.doi.org/10.1177/0162353217745159.
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Most pre-kindergarten (pre-K) and kindergarten curricula are challenging and engaging, but few are strongly grounded in science, technology, engineering, and mathematics (STEM) education. In this study, the authors examined parental perception ( N = 55) of the influences of a Saturday STEM enrichment program in one university center on pre-K and kindergarten students and their attitudes toward STEM learning. Using survey data collected from 2013 to 2016, the authors studied parental comments about benefits, drawbacks, and memorable moments they observed from their children’s experiences during the program. These comments were analyzed qualitatively using NVivo, and three main themes were developed. The themes were children’s reactions to STEM learning, meeting the needs of young gifted learners, and learning beyond the classroom. These themes reinforced current literature in the field showing young children’s need for STEM education. Sadly, few opportunities for STEM-focused programming for young children exist.
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Garb, Erica. "Maximizing the Potential of Young Adults with Visual Impairments: The Metacognitive Element." Journal of Visual Impairment & Blindness 94, no. 9 (September 2000): 574–83. http://dx.doi.org/10.1177/0145482x0009400904.
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An intervention project at the Hebrew University Learning Center for the Blind introduced metacognitive techniques to compensate for educational deficiencies in visually impaired young adults with a history of academic failure. The project, based on the Instrumental Enrichment cognitive training program, led to improvement in students’ motivation, awareness of their own learning strategies, more rapid and sustained academic progress, and increased autonomy in learning.
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Nagai, Yukari, Akio Shimogoori, Minatsu Ariga, and Georgi V. Georgiev. "Future Learning and Design Creativity Competency." Proceedings of the Design Society: International Conference on Engineering Design 1, no. 1 (July 2019): 499–508. http://dx.doi.org/10.1017/dsi.2019.54.
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AbstractIn this study, we discuss a structure for developing the skills and competencies required by the learning framework of the Organisation for Economic Co-operation and Development (OECD) for future education. Given the broad range of skills and the numerous competencies required to meet the demands of future society, the proposed wider and higher-level framework is based on STEAM (science, technology, engineering, art and design, and mathematics) and addresses the limitations of conventional computational thinking by tackling some of the skills and competencies. This is done by proposing the enrichment of STEAM educational approach with art thinking, which may be defined as a creative human-centred discovery process. To explore such enrichment, we conducted a workshop on art thinking. The motivation of the workshop was to explore whether art thinking can overcome some of the limitations of computational thinking regarding future education in the OECD learning framework. We discuss STEAM as focusing on design creativity competency, and we outline the development of educational activities such as workshops to promote competencies in the perspective of OECD framework.
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Shaham, Cahit, and Stan Sofer. "Attitudes of Gifted and Talented Pupils towards Learning Experiences and Teaching Methods at an Enrichment Center." International Journal of Learning and Development 4, no. 1 (March 21, 2014): 132. http://dx.doi.org/10.5296/ijld.v4i1.5237.
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McCartin, Lyda Fontes, Brianne Markowski, and Stephanie Evers. "Developing an assessment plan for information literacy learning outcomes: Process and planning." College & Research Libraries News 82, no. 1 (January 8, 2021): 32. http://dx.doi.org/10.5860/crln.82.1.32.
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The introduction of the ACRL Framework for Information Literacy for Higher Education provided an opportunity for libraries to revisit student learning and instruction practices. At the University of Northern Colorado Libraries, we embarked on a process of revising our shared student learning outcomes (SLOs) for all 100-level information literacy credit courses. The credit courses, taught by librarians, are offered in conjunction with programs on campus, like the Honors program and Center for Human Enrichment, or as a major requirement for Criminal Justice, History or Audiology and Speech Language majors.
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McCartin, Lyda Fontes, Brianne Markowski, and Stephanie Evers. "Developing an assessment plan for information literacy learning outcomes: Process and planning." College & Research Libraries News 82, no. 1 (January 8, 2021): 32. http://dx.doi.org/10.5860/crln.82.1.32.
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The introduction of the ACRL Framework for Information Literacy for Higher Education provided an opportunity for libraries to revisit student learning and instruction practices. At the University of Northern Colorado Libraries, we embarked on a process of revising our shared student learning outcomes (SLOs) for all 100-level information literacy credit courses. The credit courses, taught by librarians, are offered in conjunction with programs on campus, like the Honors program and Center for Human Enrichment, or as a major requirement for Criminal Justice, History or Audiology and Speech Language majors.
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Salinas-Vasquez, Laura, Daniella G. Varela, Maria E. Martinez, and Don Jones. "A Comparative Study of the 21st Century Afterschool Center on Education in Elementary Schools in South Texas." Research in Educational Policy and Management 2, no. 2 (December 12, 2020): 19–37. http://dx.doi.org/10.46303/repam.2020.2.
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This quantitative study examines the relationship between implementation of the 21st Century Afterschool Centers on Education (ACE) program and fourth grade student performance on the State of Texas Assessment of Academic Readiness (STAAR). Data was collected from public elementary schools in South Texas via the 2018-2019 Texas Academic Performance Report (TAPR) published by Texas Education Agency (TEA) for each campus. The study applied a quantitative, ex-post facto research approach, which analyzed data from fourth grade students enrolled in elementary schools. Results indicated no significant differences in STAAR performance between those campuses, which implemented ACE, and those, which did not. Thus, the findings dictate a need for policymakers’ and school leaders’ attention to ensure that enrichment programs are implemented with fidelity and appropriately designed to deliberately effect increases in student learning. Future research may seek to determine more effective enrichment program approaches for students in low-performing, high-minority serving schools.
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Magge, Arjun, Davy Weissenbacher, Karen O’Connor, Tasnia Tahsin, Graciela Gonzalez-Hernandez, and Matthew Scotch. "GeoBoost2: a natural languageprocessing pipeline for GenBank metadata enrichment for virus phylogeography." Bioinformatics 36, no. 20 (July 19, 2020): 5120–21. http://dx.doi.org/10.1093/bioinformatics/btaa647.
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Abstract Summary We present GeoBoost2, a natural language-processing pipeline for extracting the location of infected hosts for enriching metadata in nucleotide sequences repositories like National Center of Biotechnology Information’s GenBank for downstream analysis including phylogeography and genomic epidemiology. The increasing number of pathogen sequences requires complementary information extraction methods for focused research, including surveillance within countries and between borders. In this article, we describe the enhancements from our earlier release including improvement in end-to-end extraction performance and speed, availability of a fully functional web-interface and state-of-the-art methods for location extraction using deep learning. Availability and implementation Application is freely available on the web at https://zodo.asu.edu/geoboost2. Source code, usage examples and annotated data for GeoBoost2 is freely available at https://github.com/ZooPhy/geoboost2. Supplementary information Supplementary data are available at Bioinformatics online.
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Aprilia, Irma, and I. Gusti Putu Suryadarma. "E-module of mangrove ecosystem (emme): development, validation and effectiveness in improving students’ self-regulated." Biosfer 13, no. 1 (May 11, 2020): 114–29. http://dx.doi.org/10.21009/biosferjpb.v13n1.114-129.
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One of the mangrove forests in Indramayu, West Java, Indonesia that plays an essential role in the environment and becomes a learning center, is the Karangsong mangrove forest. The study aimed to determine the feasibility and effectiveness of Enrichment E-Module of Mangrove Ecosystem (EMME) to improve students' self-regulated learning. This study was Research & Development with the ADDIE model (Analysis, Design, Development, Implementation, Evaluation). This study was conducted at a Senior High School in Sindang, Indramayu, Indonesia with ten (X) grade of science class. The samples were chosen using a purposive sampling technique, resulting in class X-7 chosen as a control group and class X-8 as an experimental group. The design of this study used a non-equivalent control group design. The average validation result by experts was that media expert of 87.75 (very feasible), material expert of 94.36 (very feasible), and biology teacher of 93.40 (very feasible). The results indicated that the enriched e-module of the mangrove ecosystem was feasible in enrichment learning. E-module did not significantly influence to improve students' self-regulated learning, as seen from the result of the Mann Whitney test (0.077). Improvement of students' self-regulated learning was low, as seen from the N-gain score of the control group (0.06) and the experimental group (0.20). These concluded that the e-module of the mangrove ecosystem could be used in the learning, and short time allocation causes the module not to influence self-regulated learning significantly. Several revisions are needed in order to make the e-module more effective in improving students' self-regulated learning.
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Ruiz, Maria, Juan José Rodriguez, Gorka Erlaiz, and Iratxe Olibares. "PHYRON: cognitive computing for the creation of an innovative Intelligence Experience Center." International Journal of Production Management and Engineering 9, no. 2 (July 28, 2021): 103. http://dx.doi.org/10.4995/ijpme.2021.15300.
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<p>This research presents the results of a project called “PHYRON: Cognitive Computing for the creation of an innovative Intelligence Experience Center”, funded by the Basque Government (Economic Development, Sustainability and Environment Department). The project started in April 2019 and it will end in December 2021. Its main objective was to arrange an industrial research about cognitive computing. The main aim was the application of these systems for the development of an Intelligent Experience Center (IExC) to facilitate: i) enrichment of processes, products and services, in general client experiences, ii) automatic generation of technical predictions related to the product and the client behaviour through the exploitation of acquired knowledge, and iii) rationalization and automation of the processes that are involved in the after sale services both at technical and management level. The technological outcome presented in this paper is built using cognitive engines to enable learning from the client experience, and predictive models to anticipate client necessities.</p>
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Porter, Lon A. "Active Learning and Student Engagement via 3D Printing and Design: Integrating Undergraduate Research, Service Learning, and Cross-Disciplinary Collaborations." MRS Advances 1, no. 56 (2016): 3703–8. http://dx.doi.org/10.1557/adv.2016.82.
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ABSTRACTIn order to provide students with the training required to meet the substantial and diverse challenges of the 21st Century, effective programs in engineering, science, and technology must continue to take the lead in developing high-impact educational practices. Over the past year, faculty across several departments collaborated in the establishment of a campus 3D printing and fabrication center. This facility was founded to offer opportunities for exploring innovative active learning strategies in order to enhance the lives of Wabash College students and serve as a model to other institutions of higher education. This campus resource provides the infrastructure that will empower faculty and staff to explore diverse and meaningful cross-disciplinary collaborations related to teaching and learning across campus. New initiatives include the development of courses on design and fabrication, collaborative cross-disciplinary projects that bridge courses in the arts and sciences, 3D printing and fabrication-based undergraduate research internships, and entrepreneurial collaborations with local industry. These innovative approaches are meant to open the door to greater active learning experiences that empower and prepare students for creative and practical problem solving. Furthermore, service learning projects, community-based opportunities, and global outreach initiatives provide students with a sense of social responsibility, ethical awareness, leadership, and teamwork. This paper shares initial successes of this effort and goals for future enrichment of student learning.
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Ioannakis, G., L. Bampis, and A. Koutsoudis. "ARTIFICIAL INTELLIGENCE AS A LOW-COST SOLUTION FOR MUSEUM VISIT DIGITAL CONTENT ENRICHMENT: THE CASE OF THE FOLKLORE MUSEUM OF XANTHI." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-2/W15 (August 22, 2019): 585–90. http://dx.doi.org/10.5194/isprs-archives-xlii-2-w15-585-2019.
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<p><strong>Abstract.</strong> The on-demand content enrichment of an exhibition center visit is an active applied research domain. This work focuses on the exploitation of mobile devices as an efficient medium to deliver information related to an exhibit or an area within the exhibition center by utilizing machine learning approaches. We present YPOPSEI, an integrated system that formulates the information retrieval task as an image recognition mechanism, enabling visitors to simply capture an entity of interest in order to acquire information similar to a tour-guidance experience via their personal mobile devices. This scheme not only minimizes the additional infrastructure requirements, but additionally enhances the versatility in cases of exhibits topology alterations while still providing high accuracy in terms of image content recognition. Two hybrid approaches are developed that set Convolutional Neural Networks (CNNs) and Bags of VisualWords (BOVWs) to operate in a synergistic and cooperative manner. They are evaluated under real-world conditions on a client-server Web architecture system that experimentally operates within the premises of the Folklore Museum of Xanthi, Greece.</p>
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Gray, Tonia, and Cameron Thomson. "Transforming Environmental Awareness of Students Through the Arts and Place-Based Pedagogies." LEARNing Landscapes 9, no. 2 (April 1, 2016): 239–60. http://dx.doi.org/10.36510/learnland.v9i2.774.
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Incorporating the Arts into immersive place-based education programs can increase connectivity with the environment and facilitate the development of socially responsible and pro-environmental learners. Increasingly, children and adolescents are alienated and detached from the natural world. Given this noticeable shift, educators working in the outdoor setting need to rethink their modus operandi. Past attempts to promote learner connection with the environment have centred upon short-term stays and risk-centric approaches that embrace high adrenaline activities. This is the antithesis of Touched By The Earth, a yearlong place-based enrichment program using multi-modal creative methods with young learners to delve into the impact of experiential learning and how the Arts promote a personal relationship with the environment.
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Spence, Bonnie S. "The Arcs of Archaeology." Mathematics Teaching in the Middle School 1, no. 9 (March 1996): 688–93. http://dx.doi.org/10.5951/mtms.1.9.0688.
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For the past several years, i have sought out opportunities outside mathematics for personal enrichment and enjoyment. These experiences have caused me to become more aware of the connections between mathematics and other areas. As a result, I have begun developing lessons to show my students how mathematics is used in the real world. One summer I joined another teacher and twelve middle school students and decided to brave the eighteen-hour drive from Oklahoma to the Crow Canyon Archaeological Center in Co1tez, Colorado. The mathematical lesson discussed in this article emerged from one week of learning about the Anasazi culture and experiencing hands-on archaeology. Throughout the years, this lesson has been revised and expanded as both students and experience have given me new ideas.
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Wang, Jun, Qianying Liu, Haotian Xie, Zhaogang Yang, and Hefeng Zhou. "Boosted EfficientNet: Detection of Lymph Node Metastases in Breast Cancer Using Convolutional Neural Networks." Cancers 13, no. 4 (February 7, 2021): 661. http://dx.doi.org/10.3390/cancers13040661.
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(1) Purpose: To improve the capability of EfficientNet, including developing a cropping method called Random Center Cropping (RCC) to retain the original image resolution and significant features on the images’ center area, reducing the downsampling scale of EfficientNet to facilitate the small resolution images of RPCam datasets, and integrating attention and Feature Fusion (FF) mechanisms with EfficientNet to obtain features containing rich semantic information. (2) Methods: We adopt the Convolutional Neural Network (CNN) to detect and classify lymph node metastasis in breast cancer. (3) Results: Experiments illustrate that our methods significantly boost performance of basic CNN architectures, where the best-performed method achieves an accuracy of 97.96% ± 0.03% and an Area Under the Curve (AUC) of 99.68% ± 0.01% on RPCam datasets, respectively. (4) Conclusions: (1) To our limited knowledge, we are the only study to explore the power of EfficientNet on Metastatic Breast Cancer (MBC) classification, and elaborate experiments are conducted to compare the performance of EfficientNet with other state-of-the-art CNN models. It might provide inspiration for researchers who are interested in image-based diagnosis using Deep Learning (DL). (2) We design a novel data augmentation method named RCC to promote the data enrichment of small resolution datasets. (3) All of our four technological improvements boost the performance of the original EfficientNet.
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Wijaya, Manggara Bagus Satriya, Hermanu Joebagio, and Sariyatun Sariyatun. "Konstruksi Pembelajaran Sejarah Islam Berbasis Teks Kajen dan Serat Cebolek dengan Pendekatan Ways of Knowing." JUSPI (Jurnal Sejarah Peradaban Islam) 2, no. 2 (December 12, 2018): 29. http://dx.doi.org/10.30829/j.v2i2.1676.
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<p align="center"><em>Learning History in the Curriculum as a whole emphasizes the importance of collective memory so that inhibits the growth of critical reasoning in the Student.</em> <em>This review covers an alternative approach in teaching history subjects applied in senior high school. The use of the concept of critical questions and emancipatory models of "ways of knowing" by Juergen Habermas is a strategy taken by teachers in teaching history lessons that can arouse the critical awareness of student. In-depth research is done by qualitative method to know the activity of teachers and learners thoroughly at the time of learning about the history of Shaykh Ahmad Mutamakkin and the settlement of his case stipulated in the Kajen manuscript and Cebolek manuscript as enrichment of the material history Mataram Islamic Kingdom.</em> <em>The results showed that during the learning prose took place the teacher has succeeded in creating the creation of the process of emancipation in the students themselves.</em> <em>Such emancipation enables an increase in the interest of learners to create their own knowledge on the material discussed in a historical perspective</em></p><p>Kata kunci: <em>local wisdom in history, critical pedagogy in teaching history, </em><em>emancpatory reserach</em></p>
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Himayaturohmah, Emma. "STRATEGI PENGEMBANGAN MANAJEMEN PENGELOLAAN PUSAT KEGIATAN BELAJAR MASYARAKAT (PKBM) DI PROVINSI RIAU." Jurnal Penjaminan Mutu 3, no. 1 (February 28, 2017): 100. http://dx.doi.org/10.25078/jpm.v3i1.96.
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<p>Community Learning Center (CLC) is a non-formal education institution that serves as a place and opportunity for the community members to learn. CLC develops as learners’ needs, educational regulations, and general society develop. The implementation of learning activities differs from one CLC to another. The quality also varies between one CLC institution and the next. The quality of human resources in CLC contributes to the quality of the CLC. The key human resource that plays a great role in determining the success or failure of CLC is its manager. Managerial ability of CLC managers is one of the key factors of CLC’s success. To improve the quality of CLC, the quality of its managers has to be improved first. CLC managers have to possess sufficient knowledge, skills, and capabilities to realize the nine characters of CLC set in the Standard and Operational Procedures of CLC. Nowadays, CLC faces several problems in quality improvement: (1) whether or not the developed learning programs are oriented towards the learners and stakeholders; (2) whether or not all stakeholders of CLC are actively involved in the management and development of CLC; (3) whether or not learning implementation and evaluation been performed as required; it is unlikely that CLC will meet the quality standard set by the community without first having a tool to measure its progress and achievement; (4) whether or not all interested parties have strong commitment to quality improvement; and (5) whether or not the improvement and development efforts in CLC management and learning implementation have been continuous and sustainable. One of the quality improvement efforts in CLC is the development of managerial professionalism. The managers of CLC may implement CLC managerial development strategies, which begin with strategic planning. Managerial development strategies include effective and efficient management of resources and the implementation of skill development and public enrichment approaches.</p>
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Chung, Yumin, Kyueng-Whan Min, Dong-Hoon Kim, Byoung Kwan Son, Sung-Im Do, Seoung Wan Chae, and Mi Jung Kwon. "High BMI1 Expression with Low CD8+ and CD4+ T Cell Activity Could Promote Breast Cancer Cell Survival: A Machine Learning Approach." Journal of Personalized Medicine 11, no. 8 (July 28, 2021): 739. http://dx.doi.org/10.3390/jpm11080739.
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BMI1 is known to play a key role in the regulation of stem cell self-renewal in both endogenous and cancer stem cells. High BMI1 expression has been associated with poor prognosis in a variety of human tumors. The aim of this study was to reveal the correlations of BMI1 with survival rates, genetic alterations, and immune activities, and to validate the results using machine learning. We investigated the survival rates according to BMI1 expression in 389 and 789 breast cancer patients from Kangbuk Samsung Medical Center (KBSMC) and The Cancer Genome Atlas, respectively. We performed gene set enrichment analysis (GSEA) with pathway-based network analysis, investigated the immune response, and performed in vitro drug screening assays. The survival prediction model was evaluated through a gradient boosting machine (GBM) approach incorporating BMI1. High BMI1 expression was correlated with poor survival in patients with breast cancer. In GSEA and in in silico flow cytometry, high BMI1 expression was associated with factors indicating a weak immune response, such as decreased CD8+ T cell and CD4+ T cell counts. In pathway-based network analysis, BMI1 was directly linked to transcriptional regulation and indirectly linked to inflammatory response pathways, etc. The GBM model incorporating BMI1 showed improved prognostic performance compared with the model without BMI1. We identified telomerase inhibitor IX, a drug with potent activity against breast cancer cell lines with high BMI1 expression. We suggest that high BMI1 expression could be a therapeutic target in breast cancer. These results could contribute to the design of future experimental research and drug development programs for breast cancer.
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Rahman, Taufik. "MANAGEMENT OF ONLINE BASIC LEVEL OF LEVELED TRAINING FOR TO IMPROVE THE COMPETENCE OF EARLY CHILDHOOD AND CARE EDUCATION (ECCE) TEACHERS (Case Study at PP PAUD and DIKMAS West Java)." Empowerment 7, no. 2 (September 30, 2018): 313. http://dx.doi.org/10.22460/empowerment.v7i2p313-318.923.
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Abstract The Center for Development of Early Childhood Education and Community Education (PP PAUD and Dikmas) West Java has programmed Online Basic Level of Leveled Training for Early Childhood and Care Education (ECCE) Teachers. The Leveled Training consists of basic, intermediate, and advance level which are constructed to improve the competence of three levels of ECCE teachers (junior assistance, assistance, and ECCE teachers), continuously and gradually. The online basic level training is supposed to provide junior assistant of ECCE teacher with minimum competency.The focus this study is to investigate how the management of online basic level training in improving the competence of ECCE teachers developed by PP PAUD and Dikmas West Java.The Purpose of this study is to describe the planning, implementation and evaluation of online basic level training in improving the competence of ECCE teachers. Supporting theories of this study are the management concept, training, online learning and competency of ECCE teachers.The methodology used in this study is descriptive qualitative with ex-post facto approach. The data obtained through analysis of documents and interviews with the organizer, instructor, mentor, administrator and alumni of Training. The subjects are five people consisting of the organizer, instructor, mentor, administrator and alumni of Training.Based on the analysis of data and discussion of research result, the findings are: (1) planning phase of online training was done with writing design, setting up learning media and tools, designing Content Management System (CMS) and Learning Management System (CMS); (2) Implementation of the online basic level Training employed three main strategies, i.e. face-to-face online, tutorials online and independent learning; (3) Evaluation of the online basic level Training was divided into two parts, the evaluation results include (a) cognitive, (b) affective (c) psychomotor, and program evaluation.Recommendations for the organizers are to increase server capacity, improve the Content Management System and Learning Management System, develop online intermediate and advance levels of leveled Training for improving the competence of ECCE teachers and develop other online trainings. Recommendation for the instructors and mentors are to provide more intensive enrichment of training materials, of operating IT and online activities, and completing of SOP of supervisors and mentors. Keyword : Management, online Training, ECCE teachers
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Liu, Bolin, and Liyang Xie. "An Improved Structural Reliability Analysis Method Based on Local Approximation and Parallelization." Mathematics 8, no. 2 (February 7, 2020): 209. http://dx.doi.org/10.3390/math8020209.
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The Kriging-based reliability method with a sequential design of experiments (DoE) has been developed in recent years for implicit limit state functions. Such methods include the efficient global reliability analysis, the active learning reliability method combining Kriging and MCS Simulations. In this research, a novel local approximation method based on the most probable failure point (MPFP) is proposed to improve such methods. In this method, the MPFP calculated in the last iteration is the center of the next sampling region. The size of the local region depends on the reliability index obtained by the First Order Reliability Method (FORM) and the deviation distance of the standard deviation. The proposed algorithm, which approximates the limit state function accurately near MPFP rather than in the whole design space, can avoid selecting samples in regions that have negligible effects on the reliability analysis results. In addition, a multi-point enrichment technique is also introduced to select multiple sample points in each iteration. After the high-quality approximation of limit state function is obtained, the failure probability is calculated by the Monte Carlo method. Four numerical examples are used to validate the accuracy and efficiency of the proposed method. Results show that the proposed method is very effective for an accurate evaluation of the failure probability.
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Liang, Thow Yick. "Intelligence strategy: the evolutionary and co-evolutionary dynamics of intelligent human organizations and their interacting agents." Human Systems Management 23, no. 2 (June 3, 2004): 137–49. http://dx.doi.org/10.3233/hsm-2004-23208.
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In the knowledge economy, the human minds are the most vital center of analysis. They are the complex adaptive systems capable of processing information, establishing knowledge structure, conceptualizing idea, and making decision. The intrinsic intelligence of the individual minds, as well as the organizational/collective intelligence, drives the dynamic of all human systems. Primarily, the local self-enrichment processes of the interacting agents are autopoietic. In addition, global forces are also present in all human organizations. The global forces are constructive only if they support the elementary processes. The global forces originate from the orgmind of the organization. A complex relationship exists between the interacting agents and their systems. Traditionally, the decision-making dynamic of the human thinking systems has been dealt with in economics concepts such as the “economic” man that focuses on perfect rational decision, and Herbert Simon's “administrative” man that incorporates the idea of bounded rationality. In this study, the dynamic of an “intelligent” person is introduced. An intelligent person does not concentrate on optimality at all times. Instead, such a person adopts the intelligence strategy. An intelligent person is mindful and contributes continuously towards the collective intelligence of the system. The mindset of an intelligent person encompasses continual fast learning, longer-term survival, exploitation of the butterfly effect, and co-evolution with his/her system. In this respect, an intelligent person is a rather dissimilar interacting agent.
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Sayyidi, Sayyidi, and Muhammad Abdul Halim Sidiq. "Reaktualisasi Pendidikan Karakter di Era Disrupsi." Bidayatuna: Jurnal Pendidikan Guru Mandrasah Ibtidaiyah 3, no. 1 (April 19, 2020): 105. http://dx.doi.org/10.36835/bidayatuna.v3i01.520.
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The development of education always changes with the times, the wider the access to interaction the wider the challenges. Students who have been educated in the past face real challenges today, while children who are currently educated will face challenges in the future. The transformation of education has indeed become an inevitable necessity to keep up with the flow of disruption. Education in the past was quite easy to make children become obedient and easily regulated individuals even though the function of three education center was imbalanced and mostly played a role in the school environment. However, the results are satisfying in shaping the character and personality of a good child. It is different from the current conditions in which the role of the family and community education environment must begin to be played maximally. This condition is the impact of the era of disruption that can not be dammed, not only the mindset of students who are contaminated by the thought of "free learning" according to their assumptions and perceptions, teachers have also begun to be infected with "viruses" of materialistic thinking transmitted by the world of disruption. Educators, parents, and the community need to understand the importance of character-based education transformation, education that shapes professional, independent, and Islamic personalities.
To realize the dream of character education there needs to be an awareness of learning and teaching. Educators must change the mindset in teaching, change patterns and habits in the school, family and community environment, with the aim that they can be actively involved. Educators need to find ways, think about it and combine Islamic values and local culture. The involvement of educators in the above three environments is believed to be able to neutralize the negative seduction caused by the sophistication of globalization. So that Education can be interpreted as an effort to transform knowledge (transfer of knowledge), enrichment of value (transfer of value), knowledge of cultural character (transfer of culture), and inculcation of religious values (transfer of religious) towards the orientation of changing patterns of individual behavior so that it has sublime value and is intelligent as well as skilled.
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Karsznia, Izabela, and Karolina Sielicka. "Exploring essential variables in the settlement selection for small-scale maps using machine learning." Abstracts of the ICA 1 (July 15, 2019): 1–2. http://dx.doi.org/10.5194/ica-abs-1-162-2019.
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<p><strong>Abstract.</strong> The decision about removing or maintaining an object while changing detail level requires taking into account many features of the object itself and its surrounding. Automatic generalization is the optimal way to obtain maps at various scales, based on a single spatial database, storing up-to-date information with a high level of spatial accuracy. Researchers agree on the need for fully automating the generalization process (Stoter et al., 2016). Numerous research centres, cartographic agencies as well as commercial companies have undertaken successful attempts of implementing certain generalization solutions (Stoter et al., 2009, 2014, 2016; Regnauld, 2015; Burghardt et al., 2008; Chaundhry and Mackaness, 2008). Nevertheless, an effective and consistent methodology for generalizing small-scale maps has not gained enough attention so far, as most of the conducted research has focused on the acquisition of large-scale maps (Stoter et al., 2016). The presented research aims to fulfil this gap by exploring new variables, which are of the key importance in the automatic settlement selection process at small scales. Addressing this issue is an essential step to propose new algorithms for effective and automatic settlement selection that will contribute to enriching, the sparsely filled small-scale generalization toolbox.</p><p>The main idea behind this research is using machine learning (ML) for the new variable exploration which can be important in the automatic settlement generalization in small-scales. For automation of the generalization process, cartographic knowledge has to be collected and formalized. So far, a few approaches based on the use of ML have already been proposed. One of the first attempts to determine generalization parameters with the use of ML was performed by Weibel et al. (1995). The learning material was the observation of cartographers manual work. Also, Mustière tried to identify the optimal sequence of the generalization operators for the roads using ML (1998). A different approach was presented by Sester (2000). The goal was to extract the cartographic knowledge from spatial data characteristics, especially from the attributes and geometric properties of objects, regularities and repetitive patterns that govern object selection with the use of decision trees. Lagrange et al. (2000), Balboa and López (2008) also used ML techniques, namely neural networks to generalize line objects. Recently, Sester et al. (2018) proposed the application of deep learning for the task of building generalization. As noticed by Sester et al. (2018), these ideas, although interesting, remained proofs of concepts only. Moreover, they concerned topographic databases and large-scale maps. Promising results of automatic settlement selection in small scales was reported by Karsznia and Weibel (2018). To improve the settlement selection process, they have used data enrichment and ML. Thanks to classification models based on the decision trees, they explored new variables that are decisive in the settlement selection process. However, they have also concluded that there is probably still more “deep knowledge” to be discovered, possibly linked to further variables that were not included in their research. Thus the motivation for this research is to fulfil this research gap and look for additional, essential variables governing settlement selection in small scales.</p>
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Prokosch, Hans-Ulrich, Till Acker, Johannes Bernarding, Harald Binder, Martin Boeker, Melanie Boerries, Philipp Daumke, et al. "MIRACUM: Medical Informatics in Research and Care in University Medicine." Methods of Information in Medicine 57, S 01 (July 2018): e82-e91. http://dx.doi.org/10.3414/me17-02-0025.
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Summary Introduction: This article is part of the Focus Theme of Methods of Information in Medicine on the German Medical Informatics Initiative. Similar to other large international data sharing networks (e.g. OHDSI, PCORnet, eMerge, RD-Connect) MIRACUM is a consortium of academic and hospital partners as well as one industrial partner in eight German cities which have joined forces to create interoperable data integration centres (DIC) and make data within those DIC available for innovative new IT solutions in patient care and medical research. Objectives: Sharing data shall be supported by common interoperable tools and services, in order to leverage the power of such data for biomedical discovery and moving towards a learning health system. This paper aims at illustrating the major building blocks and concepts which MIRACUM will apply to achieve this goal. Governance and Policies: Besides establishing an efficient governance structure within the MIRACUM consortium (based on the steering board, a central administrative office, the general MIRACUM assembly, six working groups and the international scientific advisory board), defining DIC governance rules and data sharing policies, as well as establishing (at each MIRACUM DIC site, but also for MIRACUM in total) use and access committees are major building blocks for the success of such an endeavor. Architectural Framework and Methodology: The MIRACUM DIC architecture builds on a comprehensive ecosystem of reusable open source tools (MIRACOLIX), which are linkable and interoperable amongst each other, but also with the existing software environment of the MIRACUM hospitals. Efficient data protection measures, considering patient consent, data harmonization and a MIRACUM metadata repository as well as a common data model are major pillars of this framework. The methodological approach for shared data usage relies on a federated querying and analysis concept. Use Cases: MIRACUM aims at proving the value of their DIC with three use cases: IT support for patient recruitment into clinical trials, the development and routine care implementation of a clinico-molecular predictive knowledge tool, and molecular-guided therapy recommendations in molecular tumor boards. Results: Based on the MIRACUM DIC release in the nine months conceptual phase first large scale analysis for stroke and colorectal cancer cohorts have been pursued. Discussion: Beyond all technological challenges successfully applying the MIRACUM tools for the enrichment of our knowledge about diagnostic and therapeutic concepts, thus supporting the concept of a Learning Health System will be crucial for the acceptance and sustainability in the medical community and the MIRACUM university hospitals.
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Rochbeind, Fenny, Sumarwahyudi Sumarwahyudi, and Lisa Sidyawati. "Lampion Hias Bernilai Estetika untuk Meningkatkan Kreativitas Karang Taruna." Jurnal KARINOV 3, no. 1 (January 19, 2020): 37. http://dx.doi.org/10.17977/um045v3i1p37-43.
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Kegiatan pengabdian ini diperuntukkan bagi karang taruna dikawasan wisata Kampung Heritage Kajoetangan Kota Malang. Bertujuan untuk meningkatkan kreativitas peserta, potensi diri dibidang kreatif, menambah pengetahuan dan pengalaman artistik melalui pembuatan lampion hias. Kebutuhan akan pencahayaan dilokasi kawasan wisata bukan hanya untuk keindahan tetapi memeriahkan tampilan permukiman khususnya di malam hari. Pembekalan keterampilan bagi karang taruna sangat diharapkan dan dipastikan untuk kurun waktu tertentu, secara berkesinambungan kawasan ini menjadi sentra industri kreatif berbasis budaya lokal yang memiliki nilai ekonomis yang cukup tinggi. Masalahnya aktivitas karang taruna sangat kurang dibidang kreatif, belum memiliki kompetensi mengembangkan potensi kreatif berolah seni rupa dan kerajinan untuk memperindah lingkungan yang menjadi objek kunjungan wisata sehingga perlu dilatih. Metode yang digunakan diantaranya pengayaan, metode pembelajaran, metode partisipatif, dan metode evaluasi untuk mengetahui perubahan pengetahuan, keterampilan, dan wawasan/perilaku khalayak sasaran. Manfaat dari kegiatan pelatihan penting untuk meningkatkan kreativitas peserta, mampu berwirausaha, memiliki motivasi tinggi untuk mengembangkan potensi diri, dan menggunakan keterampilan yang dimiliki untuk memperindah, memelihara, dan melestarikan lingkungan kawasan kampung wisata Kajoetangan. Kata kunci— lampion hias, kreativitas, Kampung Heritage Kajoetangan Malang. Abstract Community service activity is for young people in the tourism area of Kajoetangan Heritage Village, Malang. Aiming to increase participant's creativity, self potential in the creative field, increase knowledge and artistic experience through making decorative lanterns. The need for lighting in the tourist area is not just for beauty but enliven the appearance of settlements, especially at night. Provision of skills for youth is highly expected and ensured for a certain period of time, this area will continuously become a center for creative industries based on local culture that has a high economic value. The problem is that the activities of the youth group are very lacking in the creative field, and do not yet have the competence to develop the creative potential to work in the arts and crafts to beautify the environment that is the object of a tourist visit so they need to be trained. The methods used include enrichment, learning methods, participatory methods, and evaluation methods to determine changes in knowledge, skills, and insights/behavior of the target audience. The benefits of the training activities are important to increase the creativity of the participants, being able to become entrepreneurs, have high motivation to develop their potential, and use their skills to beautify, maintain, and preserve the environment of the Kajoetangan tourist village. Keywords— ornamental lanterns, creativity, Kampung Heritage Kajoetangan Malang
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Liu, Huiqing, Jin Lu, Zhiwan Dong, Hao Liu, Edward Salinas, Sherry Owens, Michael A. Pratta, et al. "Cell-of-Origin Subtype Prediction of Diffuse Large B-Cell Lymphoma Using Gene Expression and Proteomic Data." Blood 132, Supplement 1 (November 29, 2018): 1712. http://dx.doi.org/10.1182/blood-2018-99-116949.
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Abstract Introduction Diffuse large B-cell lymphoma (DLBCL) subtypes can be identified based on immunohistochemistry, somatic mutation and gene expression profiles. These cell-of-origin (COO) subtypes have distinct biological and pathogenic characteristics. In addition, studies have shown the association of COO with drug response such as with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) as well as targeted therapy. Therefore, proper assessment of COO subgroup is an important step in treatment selection and outcome. In this study, we sought to develop predictive COO models using RNA-Seq based gene expression profiling and plasma proteomic data, focusing on the two defined major DLBCL subtypes - germinal center B cell-like (GCB) and activated B cell-like (ABC). Methods COO subgroups of patient samples were assigned by the Hans algorithm. Data from archival formalin-fixed paraffin-embedded (FFPE) tissues were obtained using the Illumina HiSeq platform (RNA-Seq). A subset of samples were used as a training set to select differentially expressed genes (DEGs) in ABC vs. GCB lymphomas to build support vector machine (SVM) classification models. The model with best leave-one-out cross validation (LOOCV) on the training set was applied to the remaining samples to assess its initial predictive power. Gene set enrichment analysis (GSEA, Broad Institute) and key pathway analysis (KPA, Clarivate Analytics) were also utilized to further explore the underlying biology of each COO subtype. Protein expression data using the Olink Proteomics platform was obtained from baseline patient plasma samples. Protein biomarkers to differentiate ABC and GCB subgroups were identified from a set of training samples and evaluated in independent cohorts. Due to notable batch effect, batch information was included and specified as a random factor in the model. Results Genes identified by Scott et al. (Blood 2014) for COO assignment were first tested in our RNA-Seq training data of 6 GCB and 8 ABC samples. Thirteen of 15 gene markers showed significant differences between the ABC and GCB subgroups. From these markers, we further selected 6 to build machine learning models based on fold change, false discovery rate and entropy. This 6-gene signature include 3 markers relatively up-regulated in ABC subtype and 3 up-regulated in GCB subtype. A SVM model with these genes achieved 100% LOOCV on the training data and correctly predicted COO of 20/22 samples in the validating cohort with 1 GCB and 1 ABC samples misclassified. These two samples were also misclassified if a larger panel of signature genes from Scott et al. (Blood 2014) was used. KPA on the DEGs from ABC vs. GCB predicted the activation of NFKB1and STAT4/5 transcription factors as key elements upstream of the DEGs, indicating promoted signaling of NFкB and STAT pathways in ABC subgroup. On the other hand, REST was predicted as an inhibited upstream regulator of some DEGs. RCOR1, a corepressor of REST, has significantly lower expression level in the ABC subgroup in our data. These may imply the inhibition of REST/RCOR1 pathway in ABC patients. Plasma protein data from two studies were used to form a training set with 21 GCB and 6 ABC. A set of differentially expressed analytes from ABC vs. GCB were identified which included several targets of the NFкB pathway. In an independent cohort containing 5 GCB and 4 ABC plasma samples, many of these same plasma proteins showed differential expression profiles between ABC and GCB, making them potential blood-based biomarkers for COO determination. Conclusions In this study, we built a SVM model with a subset of genes from Scott et al. (Blood 2014) to accurately predict COO of refractory DLBCL from archival FFPE tissue. Further analyses of the RNA-Seq data disclosed alterations in key transcriptional hubs between the different COO subgroups. Olink plasma data from independent cohorts demonstrated potential protein markers for a plasma-based differentiation of the ABC and GCB subtypes. These biomarkers and machine learning models are being further validated using additional datasets. Disclosures Liu: Incyte Research Institute: Employment, Equity Ownership. Lu:Incyte Research Institute: Employment, Equity Ownership. Dong:Incyte Research Institute: Employment, Equity Ownership. Liu:Incyte Research Institute: Employment, Equity Ownership. Salinas:Incyte Research Institute: Employment, Equity Ownership. Owens:Incyte Research Institute: Employment, Equity Ownership. Pratta:Incyte Research Institute: Employment, Equity Ownership. Smith:Incyte Research Institute: Employment, Equity Ownership. Tada:Incyte Research Institute: Employment, Equity Ownership. Newton:Incyte Research Institute: Employment, Equity Ownership. Burn:Incyte Research Institute: Employment, Equity Ownership.
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Saba, Nakhle S., Mondana Ghias, Rekha Manepalli, Kevin Schorno, Scott Weir, Christopher Austin, Kami Maddocks, et al. "Auranofin Induces a Reversible In-Vivo Stress Response That Correlates With a Transient Clinical Effect In Patients With Chronic Lymphocytic Leukemia." Blood 122, no. 21 (November 15, 2013): 3819. http://dx.doi.org/10.1182/blood.v122.21.3819.3819.
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Abstract Auranofin (AF) is an oral disease-modifying anti-rheumatic agent. Using a high throughput screening assay of 2,816 FDA-approved drugs against primary tumor cells in vitro, we have previously identified AF as one of five drugs with selective anti-Chronic Lymphocytic Leukemia (CLL) activity. We have shown that AF induces oxidative stress and apoptosis in CLL cells in vitro independent of classic prognostic markers (ASH Meeting Abstract 865, 2012). Here, we evaluated the in vivo effects of AF on CLL using blood samples collected from six patients treated with single agent AF at the NIH as part of a multi-center clinical trial led by the University of Kansas Cancer Center (NCT01419691). Five CLL patients and one patient with Small Lymphocytic Lymphoma (SLL) were enrolled in this open-label phase II study of AF in relapsed/refractory patients. Patients were started on AF 6 mg daily administered orally on 28-day cycles, with a dose escalation to 9 mg after the first cycle if no grade ≥2 toxicity occurred. AF was generally well tolerated. The best response was stable disease. Sequential blood samples were obtained prior to, and during the first cycle on drug. CLL cells were isolated by density gradient centrifugation. To study the in vivo effect of AF on redox balance we used dihydroethidium (DHE) and concomitantly measured cell viability using 3,3′-dihexyloxacarbocyanine iodide (DiOC6) in CD19 gated fresh cells by flow cytometry. Within 24 hours of the first dose AF induced an average 1.8 fold increase in DHE+ CLL cells indicating increased levels of ROS. Concomitantly there was a similar increase in apoptosis as shown by Annexin V staining. The increase in ROS production and apoptosis was transient; by day 7 all these changes had reverted to baseline or were even below baseline in three patients. A concomitant and equally transient decrease in the absolute lymphocyte count (ALC) and lactate dehydrogenase (LDH) level was also observed. To investigate the in vivo effect of AF on tumor biology, total RNA (2.5 μg) from CLL cells of three patients treated with AF was profiled on Human Genome U133 Plus 2.0 arrays (Affymetrix). Three time points were analyzed: baseline (D0), after one dose of AF (D1), and a week later (D7). Compared to baseline, there were 182 genes (29-up, 153-down) whose expression changed >1.5-fold at P<.01 on D1, but only 14 genes at D7, suggesting a transient in vivo effect of auranofin on the CLL cells. Next we used a previously characterized gene signature that is regulated by the transcription factor NRF2, which is a key regulator of the cellular response to oxidative stress. We have previously shown that this NRF2 gene signature is upregulated in CLL cells treated with AF in vitro. Surprisingly, we observed that after 24 hours of in vivo therapy, AF induced a statistically significant decrease in the expression of the NRF2 signature in CLL cell and that these changes resolved by D7. To search for biologic processes leading to the gene expression changes, we used Gene Set Enrichment Analysis (GSEA). After 24 hours of in vivo treatment with AF, CLL cells displayed upregulation of genes in pathways involved in drug resistance (such as excretion and transport channels). In contrast, there was a decrease in the expression of genes involved in oxygen metabolism, DNA repair, and protein folding. With the exception of changes in genes regulating redox homeostasis, all these changes reverted back to baseline by D7. Taken together, in vivo AF appears to transiently decrease anti-oxidant defenses regulated by NRF2 concomitant with an increase in cellular ROS levels and induction of some degree of cellular apoptosis. However, in vivo an adaptive response emerged that mobilized potentially compensatory mechanisms, including induction of pathways that may prevent intracellular accumulation of AF and a decrease in cellular processes that generate ROS, such as protein folding. The transient nature of the cellular response in vivo is consistent with the limited clinical activity seen in our patients. Plans are underway to determine the AF maximum tolerated dose in CLL patients. We will continue to evaluate the in vivo effects of AF on CLL cells at higher doses. Supported by the Intramural Research Program of NHLBI and NCATS, NIH; a grant from The Leukemia and Lymphoma Society Therapy Acceleration Program to The Learning Collaborative™, as well as philanthropic support. We thank our patients for participating in these research studies. Disclosures: Off Label Use: Auranofin is not FDA approved for use in CLL.
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Steen, Chloe B., Bogdan A. Luca, Mohammad Shahrokh Esfahani, Barzin Y. Nabet, Brian Sworder, Farshad Farshidfar, Kiarash Shamardani, et al. "An Atlas of Clinically-Distinct Tumor Cellular Ecosystems in Diffuse Large B Cell Lymphoma." Blood 134, Supplement_1 (November 13, 2019): 655. http://dx.doi.org/10.1182/blood-2019-129461.
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Background: Diffuse large B cell lymphoma (DLBCL) exhibits significant clinical and biological heterogeneity, in part due to cell-of-origin subtypes, somatic alterations, and diverse stromal constituents within the tumor microenvironment (TME). Several immunologically-active lymphoma therapies are known to rely on innate and adaptive anti-tumor responses occurring within this dynamic TME, including agents that are approved (e.g., rituximab, lenalidomide, CART19, ibrutinib) or emerging (e.g., anti-CD47, checkpoint inhibitors). We hypothesized that a large-scale characterization of the cellular heterogeneity in DLBCL might reveal previously unknown biological variation in the TME linked to tumor subtypes and genotypes, therapeutic responses and clinical outcomes, with implications for future personalization of immunotherapy. Methods: Using a combination of lymphoma single-cell RNA sequencing (scRNA-seq) and bulk tumor transcriptome deconvolution (CIBERSORTx; Newman et al., Nat Biotech, 2019), we developed a new machine learning framework for identifying cellular states and ecosystems that reflect fundamental TME subtypes and distinctions in tumor biology (Fig. 1). Specifically, using CIBERSORTx, we purified the transcriptomes of B cells and 12 different TME cell types, including immune and stromal subsets, from 1,279 DLBCL tumor biopsies profiled in 3 prior studies (Reddy et al., Cell 2017; Schmitz et al., NEJM 2018; Chapuy et al., Nat Med 2018). Then, we defined distinct transcriptional states for each of the 13 cell types, which we validated at single-cell resolution, using a combination of two scRNA-seq techniques (Smart-Seq2 and 10x Chromium 5' GEP, BCR and TCR) to profile primary DLBCL, FL, and human tonsils, as well as leveraging multiple scRNA-seq datasets from previous studies. We identified robust co-associations between cell states that form tumor cellular ecosystems, which we validated in independent datasets of bulk DLBCL tumor gene expression profiles. Finally, we related TME ecosystems to defined tumor subtypes, including genotype classes, and to clinical outcomes. Results: By systematically characterizing the landscape of cellular heterogeneity in nearly 1,300 DLBCL tumors, we defined an atlas of 49 distinct transcriptional states across 13 major cell types. These novel cell states spanned diverse innate and adaptive immune effector cells of the lymphoid and myeloid lineages, as well as tumor-associated fibroblasts. Remarkably, 94% of these states (46 of 49) could be validated in a compendium of ~200,000 single-cell transcriptomes derived from lymphomas, healthy control tonsils, and other tissue types. Moreover, single cells from DLBCL, FL and tonsils best mirrored these newly discovered cell states. We next characterized the biology and potential clinical utility of each cell state. We observed clear distinctions in the transcriptional programs of immune and stromal elements between germinal center and activated B cell DLBCL, as well as between known mutational subtypes. Importantly, many cell states reflected novel phenotypic groupings, and the majority were significantly associated with overall survival (P<0.05). These findings were highly concordant both within and across 3 independent DLBCL cohorts. By identifying groups of DLBCL patients with similar communities of cellular states, we defined cohesive cellular ecosystems that collectively capture the landscape of transcriptional heterogeneity in DLBCL tumors. Patients whose tumors were assigned to these ecosystems exhibited striking variation in overall survival. Importantly, the ecosystems defined distinct subgroups that could not be fully recapitulated by known transcriptional and genetic subtypes. Moreover, several TME classes showed significant enrichments in canonical or novel tumor genotypes, suggesting an evolutionary interplay between the tumor and host microenvironment. Conclusion: We describe a novel computational framework to digitally dissect the DLBCL TME and an atlas of novel states for diverse cell types in these tumors. We show how cellular states form cohesive tumor ecosystems, which exhibit distinct clinical outcomes and novel somatic alterations. These results expand our understanding of cellular heterogeneity in DLBCL, with implications for the development of individualized immunotherapies. Disclosures Kurtz: Roche: Consultancy. Advani:Kura: Research Funding; Merck: Research Funding; Millennium: Research Funding; Pharmacyclics: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Regeneron: Research Funding; Takeda: Consultancy, Membership on an entity's Board of Directors or advisory committees; Cell Medica, Ltd: Consultancy; Kyowa Kirin Pharmaceutical Developments, Inc.: Consultancy; Stanford University: Employment, Equity Ownership; Janssen: Research Funding; AstraZeneca: Consultancy, Membership on an entity's Board of Directors or advisory committees; Seattle Genetics: Consultancy, Research Funding; Infinity Pharma: Research Funding; Bayer: Consultancy, Membership on an entity's Board of Directors or advisory committees; Bristol-Myers Squibb: Membership on an entity's Board of Directors or advisory committees, Research Funding; Celgene: Research Funding; Celmed: Consultancy, Membership on an entity's Board of Directors or advisory committees; Forty-Seven: Research Funding; Roche/Genentech: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Gilead Sciences, Inc./Kite Pharma, Inc.: Consultancy, Membership on an entity's Board of Directors or advisory committees; Autolus: Consultancy, Membership on an entity's Board of Directors or advisory committees; Agensys: Research Funding. Diehn:Roche: Consultancy; AstraZeneca: Consultancy; Novartis: Consultancy; BioNTech: Consultancy; Quanticell: Consultancy. Alizadeh:Janssen: Consultancy; Genentech: Consultancy; Pharmacyclics: Consultancy; Chugai: Consultancy; Celgene: Consultancy; Gilead: Consultancy; Roche: Consultancy; Pfizer: Research Funding.
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Torner, James, Beth R. Knudson, and Kimberly Dukes. "2234 Developing the future translational science workforce at the University of Iowa." Journal of Clinical and Translational Science 2, S1 (June 2018): 53–54. http://dx.doi.org/10.1017/cts.2018.203.
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OBJECTIVES/SPECIFIC AIMS: To evaluate the extent to which the curriculum delivered via an innovative program, the Early Scholars Certificate in Clinical and Translational Science (CCTS) at the University of Iowa (UI), develops a translational science workforce pipeline by increasing awareness of and interest in translational science as a career goal for highly prepared undergraduates. METHODS/STUDY POPULATION: The CCTS’s objective is to increase the awareness of the philosophy and tools of translational science and to incorporate critical evaluation and self-appraisal of the translational aspects of a scholar’s own research. CCTS is a 16-semester-hour (sh) academic certificate program introducing translational science concepts and careers to undergraduate students. The CCTS is a selective program with requirements including a minimum GPA, minimum sh completed, completion of course prerequisites, and already engaged and supported by mentored research. The curriculum includes electives in the area of their research interests (6 sh); graduate level Epidemiology (3 sh); Biostatistics (3 sh); and 2 core Translational Research courses (4 sh total). The first core course, an Introduction to Translational Research, is a survey course providing students the opportunity to learn how translational research is conceived and developed. It is designed to instruct the student how to interpret their research in a translational T1 to T4 paradigm. The program’s capstone course, Practicum in Translational Research, provides undergraduate students the opportunity to address how their research experience translates into clinical practice. Student’s spend the majority of this course’s contact hours in a shadowing experience with a clinician in the area of their research. Students reflect on this shadowing experience and its relevance to their academic and professional goals. The students also spend time developing skills in peer review—not only learning to provide constructive feedback to other research professionals, but also how to receive and integrate the feedback. The course includes a mock research fair where both UI faculty and classmates provide feedback that is later integrated into their capstone projects—a poster presentation at the UI Carver College of Medicine Research Fair as well as a final translational paper. As part of the ongoing evaluation of the program and graduates, we examined the participant data, the course satisfaction with content, the change in understanding of translational science, and the intention to incorporate translational science into research and career goals. We also conducted course evaluation surveys and qualitative analysis of a focus group and interviews. RESULTS/ANTICIPATED RESULTS: Since 2015, the CCTS program has introduced translational science curriculum to 20 undergraduate participants (men/woman 40%/60%; 5% Hispanic or Latino; 15% Center for Diversity and Enrichment Eligible). Areas of academic interest include: biology, genetics, engineering, bioinformatics, biochemistry, neuroscience, psychology, and microbiology. Graduates of the Certificate and degree program to date (n=8) have gone onto: Fullbright awards (1), medical school/Masters in public health (1), combined MD/PhD programs (2), biomedical PhD program (1), or currently work in translational science positions in industry (2). In questionnaire and focus group results, we found that in general, students reported increased understanding of the translational spectrum and felt the certificate program helped them clarify their educational or career goals. Data from both the focus group and the questionnaire demonstrate that students are strongly positive about the program in general, including its quality, faculty and guest speakers, structure, goals, opportunities, personality, and personnel. All students highly valued many elements of the program and each course, and particularly the opportunity for clinical shadowing. Among the questionnaire findings for 2016–17, all students (100%) rated program quality “excellent,” and 7 of 8 (87.5%) “strongly agreed” that they better understood translational science, that they saw themselves continuing in translational science research after graduation, and they were better able to communicate how their lab research fits within the translational spectrum. In each case 1 of 8 “agreed.” Participants also generally felt that their career goals had been affirmed or realigned, and that they were better able to communicate the meaning of translational science to multiple audiences. Responses on changes to career aspirations and plans were mixed, and are ambiguous. Questionnaire Item 4, “My UI curricular and/or co-curricular plans changed as a result of the CCTS program,” which had mixed responses, asked specifically about the CCTS program as a reason for change, but it is not clear if, whether, or how the program specifically wants to change curricular plans. In the focus group, students reported using their individual shadowing and lab experience in determining preferences and intentions about future career choices (e.g., whether or not to apply to medical school and/or pursue basic science research). Participants perceived the shadowing experience, complementing or contrasting their lab research, as particularly relevant in deciding about their future careers. Other themes that emerged from the focus group and/or open section of the questionnaire demonstrate the impact of various course elements on participants’ understanding of translational science and potential careers, including: quality of instruction, program and course content (including guest speakers, the shadowing experience, and the poster development process); the exposure to a range of possibilities along the translational spectrum and the expansion of ideas about what research could look like; the value of connections (to faculty, researchers and clinicians, and other CCTS students and alumni); the attributes of the cohort; and the “personality” of the program and personnel. DISCUSSION/SIGNIFICANCE OF IMPACT: Developing a pipeline for translational science workforce development has been problematic because a lack of the understanding of the need of translational research and a structuring a time efficient program for early career clinical and basic scholars. Undergraduates making critical decisions about educational paths and career goals and plans may not be aware of opportunities in translational science or the type of choices they need to make to prepare for such opportunities. Our data demonstrates that CCTS was an effective way of introducing translational science concepts and career paths to undergraduate students and potentially a powerful way to encourage them to consider these career paths. Participants in our program improved their knowledge of the field and expressed interest and intention to incorporate translational science training into their career plans. However, improvements can be made in the CCTS program. Additionally, CTSAs should consider ways to incorporate findings like these into a wider sphere of training to help develop and strengthen a translational science workforce for the future. The exposure to a variety of translational science career possibilities and specialties was important to students. Based on both focus group discussion and questionnaire data, a few students did expand slightly their sense of career possibilities, but the larger benefit may be their concrete experiences that validate or solidify their interests, making them more skilled at talking about and supporting their career goals on applications and in interviews. Shadowing did not always encourage students to go into clinical medicine, but often solidified interests or leanings students already had, giving them a more grounded basis for refining their decisions. For some students, shadowing a clinician confirmed ideas of being a physician; for others, it steered them away from it. Some now found ethical challenges, bureaucracy, or emotional challenges daunting or newly necessary to consider before focusing on clinical careers. This may be just what students need at this point, and emphasizes for them the relation between different kinds of research and application within translational science. Our evaluation suggests that CCTS contributes to academic choices for career development and additionally can help attract highly skilled students into TS research, including students of color. Future work to evaluate CCTS impact on graduates’ career outcomes will inform the translational research direction and content. In terms of program design, it could be useful to build in multiple opportunities for students to understand the diversity of translational science careers and provide students more exposure to different possibilities in clinical and translational work.
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Koseff, V. "Short contribution: the realm - Roedean enrichment and learning multi-media centre." Innovation 33, no. 1 (March 9, 2007). http://dx.doi.org/10.4314/innovation.v33i1.26524.
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"Smart Home based Big Data Analysis for Healthcare Applications." International Journal of Recent Technology and Engineering 9, no. 1 (May 30, 2020): 275–82. http://dx.doi.org/10.35940/ijrte.a1406.059120.
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At present, there is a constant migration of people is encountered in urban regions. Health care services are considered as a confronting challenging factors, there is an extremely influenced by huge arrival of people to city centre. Subsequently, places all around the world are spending in digital evolution in an attempt to offer healthy eco-system for huge people. With this transformation, enormous homes are equipped with smarter devices (for example, sensors, smart sensors and so on) which produce huge amount of indexical data and fine-grained that is examined to assist smart city services. In this work, a model has been anticipated to utilize smart home big data analysis as a discovering and learning human activity patterns for huge health care applications. This work describes and highlights the experimentation with the analysis of vigorous data analysis process that assists healthcare analytics. This procedure comprises of subsequent stages: understanding, collection, cleaning, validation, enrichment, integration and storage. It has been resourcefully utilized to processing of data types variety comprising clinical data from EHR.
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Stelfox, Martin, Mercedes Martin-Cereceda, Karim Vahed, Jillian Hudgins, Stephanie Köhnk, Usman Iqbal, Ibrahim Shameel, Joana M. Hancock, and Michael Sweet. "The Olive Ridley Project (ORP): A successful example of how to engage researchers, conservation practitioners and civil society." Research for All 5, no. 2 (September 21, 2021). http://dx.doi.org/10.14324/rfa.05.2.17.
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The Olive Ridley Project (ORP) was set up to protect sea turtles and their habitats. The project was formed in 2013, and it became a registered charity in the UK in 2016. From its inception, ORP took a multidisciplinary approach to achieve its goals. Part of its objectives, and the reason why the charity came to fruition, are related to the issue of olive ridley sea turtle (Lepidochelys olivacea) entanglement in abandoned, lost or discarded fishing gear (also known as ‘ghost gear’ or ‘ghost nets’), and the search for ghost gear and turtle entanglement ‘hot spots’ throughout the Indian Ocean. The initial ORP research questions were soon challenged by societal interests to develop inclusive educational programmes in local communities and tourist resorts that could raise awareness about the need for conservation of all sea turtle species. In February 2017, ORP opened the first veterinarian-run, fully equipped Marine Turtle Rescue Centre in the Maldives, bringing together the work of researchers, citizen scientists, volunteers, environmentalists, marine biologists and veterinarians. The present work of ORP sits on a strong and scientifically robust collaborative plan. Current ORP research projects range from sea turtle population analyses, spatial ecology, rehabilitation of injured and sick individuals, epibiont parasite analyses, precise turtle identification through photo-ID research, linking ghost gear to responsible fisheries, and analyses of ghost gear drift patterns. The programme enhances community education and outreach by engaging schoolchildren, organizing workshops, promoting sustainable use of ghost gear waste, and training citizen scientists and local fishing communities. The ORP programme encompasses many principles of research engagement, effectively combining scientific knowledge, education and action. This article explores all stages of the process (from research planning and design, to knowledge exchange and inter- and trans-disciplinary impact assessments), describing the active engagement originated by the ORP initiative. A reflective insight into the learning, enrichment and challenges of engaging researchers and community actors is also included, considering the current social and scientific framework.
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Enns, Jennifer, Marni Brownell, Alan Katz, Nathan Nickel, and Yao Nie. "Is Participation in Out-of-School Programs Linked to Students’ Health, Educational and Social Outcomes?" International Journal of Population Data Science 3, no. 4 (August 28, 2018). http://dx.doi.org/10.23889/ijpds.v3i4.707.
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IntroductionOut-of-school programs for grade K-12 students support healthy behaviours, boost academic achievement, and strengthen social networks. The Boys and Girls Clubs of Winnipeg (BGCW) have been active for 40+ years; however, little is known about how participating in their programs influences students’ short- and long-term health, educational and social outcomes.
Objectives and ApproachWe are investigating the association between participation in BGCW out-of-school programs using the individual-level data held in the population-based Manitoba Population Research Data Repository at the Manitoba Centre for Health Policy (MCHP). Data on BGCW program participation for children born 1987-2010 was linked with administrative records from the healthcare system, education system, and social services. The comparison group of non-participants was matched on age, sex, 3-digit postal code and school division. Outcomes of interest include health services use, teen pregnancy, grade repetition, high school graduation, enrollment in post-secondary institutions, receipt of income assistance, and involvement with the justice system.
ResultsWe conducted analyses of children (K-8) attending the Community Schools Investigator (CSI) summer enrichment program, an academic and recreational program that aims to combat learning loss for children in low-income neighbourhoods. After one summer of CSI, participants (n=970) were significantly more likely to repeat a grade than the matched comparison group (n=783) (5.4% CSI students repeated a grade [95% CI 3.9, 6.8] vs 2.76% comparison students [95% CI 2.20, 3.32]). However, the likelihood of CSI students repeating a grade dropped to the level of the comparison group after two or more years of participation in CSI (2.91% CSI students repeated a grade [95% CI 1.26, 4.56]). Ongoing analyses are examining how participating in CSI and other BGCW programs is linked to health and social outcomes.
Conclusion/ImplicationsOur findings suggest that engagement in a BGCW out-of-school summer program contributes to better educational outcomes for low-income students. Using the information-rich Data Repository at MCHP, we can examine additional outcomes across multiple sectors to demonstrate how out-of-school programs help young people achieve their full developmental potential.
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Merillat, Linda, and Monica Scheibmeir. "Developing a Quality Improvement Process to Optimize Faculty Success." Online Learning 20, no. 3 (July 8, 2016). http://dx.doi.org/10.24059/olj.v20i3.977.
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As part of a major shift to embed quality improvement processes within a School of Nursing at a medium-sized Midwestern university, a faculty enrichment program using a Plan-Do-Act-Study design was implemented. A central focus for the program was the development and maintenance of an online faculty resource center identified as “My Faculty Center.” Nursing faculty used the tools in My Faculty Center to assess their baseline skills in the areas of teaching & learning best practices, use of learning management system, and technology. The first goal (Goal 1) of the systematic faculty development program was to measure the impact of the Faculty Enrichment program on overall faculty development with regards to technology. The second goal (Goal 2) was to evaluate the relationship, if any, between faculty development and student evaluations. To meet Goal 2, data from IDEA end-of-course evaluations (IDEA, n.d.) and the skills assessments were correlated. Results indicated that the instructor’s desire to learn more about teaching and learning best practices was positively correlated with students providing higher scores on progress on relevant objectives, perceiving the instructor as an excellent teacher, and the course summary scores. When students rated an instructor as an excellent teacher, that instructor self-reported a higher level of applying skills in using Desire-to-Learn (D2L). Negative correlations were found between the instructor’s self-reported skills with presentation and multimedia tools and the students’ perception of progress toward objectives, excellence of course, and overall course score. Based on the initial results, future professional development will optimize adequate training on the Learning Management System (i.e. D2L), for all faculty, and emphasize the effective use of technology in the classroom.
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Starr, Rebecca Lurie, and Shrutika Kapoor. "“Our graduates will have the edge”: Linguistic entrepreneurship and the discourse of Mandarin enrichment centers in Singapore." Multilingua, November 11, 2020. http://dx.doi.org/10.1515/multi-2020-0033.
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AbstractAlthough Singapore schools are English-medium, Mandarin is a compulsory subject for students of Chinese heritage. As young Singaporeans increasingly speak English at home, the required study of Mandarin has become a source of anxiety for families. Mandarin ‘enrichment centers’, which provide supplementary language classes, leverage this anxiety in various ways, from promising top exam results to highlighting non-traditional pedagogical approaches. This analysis draws on data from the websites of 14 such centers, focusing on how these programs position learners in relation to the notion of linguistic entrepreneurship (De Costa et al. 2016). We identify three broad classes of enrichment center: Traditional, Modern Traditional, and Anti-Traditional, each offering distinct imaginings of the learner as linguistic entrepreneur. Traditional centers highlight academic achievement, promising ‘exam-focused’ strategies to optimize school performance. Modern Traditional centers, in contrast, frame enrichment as an elite lifestyle choice, emphasizing exclusivity and luxury. Finally, Anti-Traditional centers distance themselves from conventional pedagogy, and invoke notions of holistic, experiential learning. Across these categories, we observe a common discourse of Mandarin learning as a character-building struggle, in which centers provide unique resources enabling learners to survive the Singapore education system and emerge as ideal neoliberal subjects who have maximized their potential.
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Steinberg, Daniel Jonathan, Shannon L. Greco, and Kimberly Carroll. "Innovative Evaluation of Two Materials Science Education Enrichment Programs." MRS Proceedings 1233 (2009). http://dx.doi.org/10.1557/proc-1233-pp07-01.
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AbstractThe Princeton Center for Complex Materials (PCCM) is an NSF-funded Materials Science and Research Center (MRSEC) at Princeton. PCCM currently has four Interdisciplinary Research Groups (IRGs) and several seed projects. PCCM runs a variety of education outreach programs that include: Research Experience for Undergraduates, Research Experience for Teachers, Materials Camp for Teachers, Middle School Science and Engineering Expo (SEE) for 1200 students, and Princeton University Materials Academy (PUMA), for inner city high school students. In this paper we focus on new evaluation efforts for the PUMA and the Science and Engineering Expo. We will discuss first PUMA the SEE and elaborate on the new evaluation efforts for each program.Created in 2002 by PCCM, PUMA has an inquiry based materials science curriculum designed to work at the high school level. PUMA's activities are paired with an inquiry based evaluation of scientific ability and attitude change. An evaluation of high school students' ability to formulate scientific questions as a result of their participation in this summer program based was developed based on similar studies of college students questioning ability in inquiry learning environments. Created in 2004 by PCCM and partners in Molecular Biology, SEE is run once per year in the spring. It is a day dedicated to capturing the imaginations of young students through science demonstrations and direct interaction with materials scientists and engineers. 1000 middle school students from local schools come to Princeton University to interact with Princeton scientists and engineers and explore science with the help of demonstrations and hands-on activities. Throughout the day, they explore a wide range research from Princeton that is at the cutting edge of science and engineering to generate excitement about science and engineering. In addition to studying over 5000's student written essays we have constructed a pre and post test for student attitudes administered to over 500 students in 2009 to determine the impact of the SEE on students' attitudes about materials science and STEM fields. This large scale attitude assessment and student written statements help to establish the impact of this one day program.
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Gibson-Langford, Linda. "Action Research." IASL Annual Conference Proceedings, February 10, 2021. http://dx.doi.org/10.29173/iasl7662.
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Teachers need to rigorously and systematically reflect on their practice and such reflection can be most effective within collaborative cultures. Within the context of action research, centred on how literature can enrich students’ world views, this paper offers an observation on collaboration as intense professional enrichment. The action research gave clear evidence that literature can shape and enrich boys’ understandings of masculinities. It also highlighted the power of collaboration in learning and teaching. As a consequence of this research, the teacher librarian and the Head of English developed trust and appreciation of each others’ craft knowledge and engaged in significant risk-taking, through creating, sharing and using their knowledge.
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Day, Deborah A., Zizi Yu, Zelun Wang, Jennifer Dalecki, Arian Jadbabaie, Emily Z. Feng, Thomas J. Mattessich, Christine Caragianis-Broadbridge, Mark A. Reed, and Ryan Munden. "Authentic Science Research and the Utilization of Nanoscience in the Non-Traditional Classroom Setting." MRS Proceedings 1233 (2009). http://dx.doi.org/10.1557/proc-1233-pp04-32.
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AbstractApplications of nanoscience in the non-traditional classroom have successfully exposed students to various methods of research with applications to micro- and nano-electronics. Activities obtained from the NanoSense website associated with current global energy and water concerns are solid examples. In this regard, all 36 students in the 2008-2009 Science Research Program (SRP) prepared and delivered individual and group lesson plans in addition to their authentic, year-long research projects. Two out of 36 students selected nanoscience based projects in preparation for science fair competition in 2009. Additionally, preliminary research was conducted while participating in the Center for Research on Interface Structures and Phenomena (CRISP) Research Experience for Teachers (RET) Program in summer 2008 which supported the idea of developing a photolithography kit. This kit is intended to introduce high school students to the fundamentals of photolithography. In this paper, the design, implementation and feasibility of this kit in the high school classroom is described as well as details involving individual and group nanoscience based projects. Supporting educational models include self-regulated learning (SRL) concepts; situated cognition; social constructivism; Renzulli's (1977) enrichment triad and Types I – III inquiry enrichment activities.
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Chi, Junxia, Shizeng Song, Hao Zhang, Yuanning Liu, Hengyi Zhao, and Liyan Dong. "Research on the Mechanism of Soybean Resistance to Phytophthora Infection Using Machine Learning Methods." Frontiers in Genetics 12 (February 11, 2021). http://dx.doi.org/10.3389/fgene.2021.634635.
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Since the emergence of the Phytophthora sojae infection, economic losses of 10–20 billion U.S. dollars have been annually reported. Studies have revealed that P. sojae works by releasing effect factors such as small RNA in the process of infecting soybeans, but research on the interaction mechanism between plants and fungi at the small RNA level remains vague and unclear. For this reason, studying the resistance mechanism of the hosts after P. sojae invades soybeans has critical theoretical and practical significance for increasing soybean yield. The present article is premised on the high-throughput data published by the National Center of Biotechnology Information (NCBI). We selected 732 sRNA sequences through big data analysis whose expression level increased sharply after soybean was infected by P. sojae and 36 sRNA sequences with massive expression levels newly generated after infection. This article analyzes the resistance mechanism of soybean to P. sojae from two aspects of plant’s own passive stress and active resistance. This article analyzes the resistance mechanism of soybean to P. sojae from two aspects of plant’s own passive stress and active resistance. These 768 sRNA sequences are targeted to soybean mRNA and P. sojae mRNA, and 2,979 and 1,683 targets are obtained, respectively. The PageRank algorithm was used to screen the core functional clusters, and 50 core nodes targeted to soybeans were obtained, which were analyzed for functional enrichment, and 12 KEGG_Pathway and 18 Go(BP) were obtained. The node targeted to P. sojae was subjected to functional enrichment analysis to obtain 11 KEGG_Pathway. The results show that there are multiple Go(BP) and KEGG_Pathway related to soybean growth and defense and reverse resistance of P. sojae. In addition, by comparing the small RNA prediction model of soybean resistance with Phytophthora pathogenicity constructed by the three machine learning methods of random forest, support vector machine, and XGBoost, about the accuracy, precision, recall rate, and F-measure, the results show that the three models have satisfied classification effect. Among the three models, XGBoost had an accuracy rate of 86.98% in the verification set.
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Beaver, Mariah, Akanksha Bhatnagar, Priyalakshmi Panikker, Haolin Zhang, Renee Snook, Visha Parmar, Gayathri Vijayakumar, Niteesha Betini, Sunya Akhter, and Felice Elefant. "Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases." Scientific Reports 10, no. 1 (October 26, 2020). http://dx.doi.org/10.1038/s41598-020-75035-3.
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AbstractEpigenetic dysregulation is a common mechanism shared by molecularly and clinically heterogenous neurodegenerative diseases (NDs). Histone acetylation homeostasis, maintained by the antagonistic activity of histone acetyltransferases (HATs) and histone deacetylases (HDACs), is necessary for appropriate gene expression and neuronal function. Disruption of neural acetylation homeostasis has been implicated in multiple types of NDs including Alzheimer’s disease (AD), yet mechanisms underlying alterations remain unclear. We show that like AD, disruption of Tip60 HAT/HDAC2 balance with concomitant epigenetic repression of common Tip60 target neuroplasticity genes occurs early in multiple types of Drosophila ND models such as Parkinson’s Disease (PD), Huntington’s Disease (HD) and Amyotrophic Lateral Sclerosis (ALS). Repressed neuroplasticity genes show reduced enrichment of Tip60 and epigentic acetylation signatures at all gene loci examined with certain genes showing inappropriate HDAC2 repressor enrichment. Functional neuronal consequences for these disease conditions are reminiscent of human pathology and include locomotion, synapse morphology, and short-term memory deficits. Increasing Tip60 HAT levels specifically in the mushroom body learning and memory center in the Drosophila brain protects against locomotion and short-term memory function deficits in multiple NDs. Together, our results support a model by which Tip60 protects against neurological impairments in different NDs via similar modes of action.
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Murniati, Murniati, and Junita Junita. "TEACHING ENGLISH TO THE TEACHERS OF SPECIAL NEEDS STUDENTS AT PANTI SOSIAL BINA GRAHITA BELAIAN KASIH." Jurnal Pengabdian dan Kewirausahaan 5, no. 1 (March 31, 2021). http://dx.doi.org/10.30813/jpk.v5i1.2727.
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<p align="center"><strong><em>ABSTRACT</em></strong></p><p><strong><em> </em></strong></p><p><em> All teaches need to improve themselves in terms of content and the teaching methods. Unfortunately, there has been a little enrichment delivered due to the pandemic which still occurs in 2021. This community service, therefore, is delivered to the teachers of special needs students at Panti Sosial Bina Grahita Belaian Kasih since to enrich their English knowledge as well as teaching skills for the special needs students. Needs analysis was administered to find (1) the Present Situation Analysis of the teachers, (2) the Learning Situation Analysis which cover the delivery of the community services, and (3) the Target Situation Analysis which cover the topics delivered during the community services. It was found out that there were twelve (12) teachers who would join this enrichment English class. Since bot all of them were English teachers, the English content should also be discussed during the community services. Next, the community services delivered five times through google meet and zoom meeting, on Wednesdays and Fridays in March 2021. The topics delivered are (1) learning styles and teaching methods for special needs students, (2) the English alphabets, (3) shapes and colors, (4) emotions, and (5) action verbs in English. The community services ran well. For better results, more meetings are needed to enrich the teachers’ teaching skills as well as their English abilities and knowledge, especially which are related to the special needs students. </em><strong><em></em></strong></p><p><strong><em><br /></em></strong><em></em></p>
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Ilhaq, Muhsin, and Rio Eka Putra. "Penggarapan Ragam Hias dengan Teknik Gradasi pada Pembelajaran Seni Rupa." Besaung : Jurnal Seni Desain dan Budaya 4, no. 2 (September 12, 2019). http://dx.doi.org/10.36982/jsdb.v4i4.797.
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<p class="SammaryHeader" align="center"><strong>ABSTRACT</strong></p><p><em>Learning resources are basically available in the surrounding environment. A learning approach based on the surrounding environment will provide a more interesting learning experience and can stimulate positive motivation. In order for the learning process to be carried out well, enrichment of the learning resources needs to be done. This study aims to get an overview of learning methods based on the surrounding environment by utilizing decorative ornaments at the Palembang Great Mosque as a learning resource. Furthermore, through this research researchers are expected to get a formulation of the use of decorative ornaments at the Palembang Great Mosque as a source of learning. Aside from being a form of support for the government in the context of inheritance and maintaining physical cultural products in the form of written documentation. It is very rare to find art textbooks, especially about decoration. In fact, the author has not yet found a textbook specifically discussing the various decorations in Palembang, so this research needs to be done. The author is of the opinion that, the use of ornamental diversity at the Palembang Grand Mosque as a source of learning art knowledge can be done through two methods namely, observing forms of ornamentation directly in the field or through enriching learning resources.</em></p><p><strong><em>Keyword</em></strong><strong><em>s :</em></strong><em> Learning Resources, Decorative Ornament, visual arts learning</em></p><p class="SammaryHeader" align="center"><strong>ABSTRAK</strong></p><p><em>Sumber belajar pada dasarnya sudah tersedia di lingkungan sekitar. Pendekatan belajar berbasis pada lingkungan sekitar akan memberikan pengalaman belajar yang lebih menarik dan dapat merangsang motivasi positif. Agar proses belajar terlaksana dengan baik, maka pengayaan sumber belajar perlu dilakukan. Penelitian ini bertujuan untuk mendapatkan gambaran metode pembelajaran berbasis lingkungan sekitar dengan memanfaatkan ragam hias pada mesjid Agung Palembang sebagai sumber belajar. Selanjutnya, melalui penelitian ini diharapkan peneliti mendapatkan suatu formulasi pemanfaatan ragam hias pada Mesjid Agung Palembang sebagai sumber belajar. Di samping sebagai bentuk dukungan terhadap pemerintah dalam rangka pewarisan dan menjaga produk budaya fisik berupa dokumentasi tertulis. Sangat jarang ditemukan buku teks seni rupa, terutama tentang ragam hias. Faktanya, penulis belum menemukan buku teks secara khusus membahas ragam hias yang ada di Palembang, sehingga dengan demikian penelitian ini perlu dilakukan. Penulis berpendapat bahwa, Pemanfaatan ragam hias pada Mesjid Agung Palembang sebagai sumber belajar pengetahuan seni rupa dapat dilakukan melalui dua metode yakni, pengamatan bentuk ragam hias secara langsung di lapangan maupun melalui pengayaan sumber belajar.</em></p><strong><em>Kata kunci :</em></strong><em> Sumber Belajar, Ragam Hias, Pembelajaran seni rupa</em>
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Putra, Hardiansyah, and Sumijan. "Penentuan Tingkat Kompetensi Soft Skill Mahasiswa Menggunakan Metode Analytical Hierarchy Process dan Promethee." Jurnal Informasi dan Teknologi, September 30, 2020, 76–82. http://dx.doi.org/10.37034/jidt.v2i3.62.
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Bureau of Student Advisory Center (BSAC) Universitas Pembangunan Panca Budi is a center for career development and character building for students. In this case, a soft skill seminar is conducted to find the best candidate employees in the field of recruitment offered based on the criteria of student soft skill training. Determining the level of soft skill competences of students using the Analytical Hierarchy Process (AHP) method and the Preference Ranking Organization Method for Enrichment Evaluation (PROMETHEE). For decision support systems using the AHP and PROMETHEE methods in determining the level of soft skill competencies, in order to obtain prospective employees who have the required soft skill competency level. Data collection was carried out by conducting research. The data is taken from the seminar results with 100 participants. The data that has been collected, processed and analyzed before being used as input and output as a basis for learning or training using the AHP and Promethee methods. Based on the calculations of the two methods, namely the AHP and Promethee methods, there are differences in calculations. In other words, because Promethee does not support the determination of weights and the hierarchy of criteria and does not have the assurance of consistency when determining weights like AHP. So that the program execution has a different time in the results, in the AHP method, program execution until the final result is obtained is better than the Promethee method. AHP has advantages in determining weights and criteria hierarchy, while Promethee has advantages in the alternative ranking process using different preference and weight functions.
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Khan, Ishrat, James Reed, Myron Williams, and Madge Willis. "Materials Science Research to Open Doors for Economically Disadvantaged High School Students: The ACS Project SEED Program at Clark Atlanta University." MRS Proceedings 1716 (2014). http://dx.doi.org/10.1557/opl.2014.910.
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ABSTRACTThe Center for Functional Nanoscale Materials (CFNM), an NSF Center for Research Excellence in Science and Technology, at Clark Atlanta University has partnered with ACS (American Chemical Society) Project SEED. The ACS project SEED program is recognized nationally as providing hands-on research opportunities to disadvantaged high school students who historically lack exposures to scientific careers. The University is a minority serving institution (MSI) and has an excellent relationship with Atlanta area school systems, which serve the African American community. Students entering their junior and senior years in high school were selected based on their academic performance, an essay and letters of recommendation for participation the Center’s eight week summer nanoscholar Program. Professors served as advisors and/or mentors and graduate students and doctoral fellows served as mentors. The Program included a variety of enrichment activities. All summer nanoscholars had personal research projects that were integral to the research programs of their advisors, and they presented their work in the form of a symposium at the end of the Program. We have completed three summers as an ACS Project SEED site. So far we have had one SEED scholar submit a major manuscript, two were invited to present at ACS National Meetings and one was awarded an eight year Gates-Millennium fellowship. Evaluation of the project strongly suggests that our approach is effective for opening doors for the economically disadvantaged students and tapping the best and the brightest for careers in the sciences and engineering. In the words of one of our young scholars “I realized that research is a continuous learning process. You can never know everything. Even a professor has credentials but they’re still continuing to learn.”