Dissertations / Theses on the topic 'Learning – Effect of glucose on'
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Owen, Lauren. "The effect of glucose on cognition." Thesis, Lancaster University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538621.
Full textPuthanveetil, Prasanth Nair. "Glucocorticoid and its effect on cardiac glucose utilization." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/5038.
Full textChen, Mimi Zhu. "The effect of bariatric surgery on glucose homeostasis." Thesis, University of Bristol, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665171.
Full textMessier, Claude. "Effect of glucose on memory : examination of possible mechanisms." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74362.
Full textQuinn, C. E. "Vascular function in impaired glucose tolerance : Effect of pioglitazone." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501394.
Full textInteeworn, Natalie. "The Effect of Hypothyroidism on Glucose Tolerance in Dogs." Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/32030.
Full textMaster of Science
Winnick, Jason Joseph. "Effect of aerobic exercise on peripheral glucose uptake and endogenous glucose production in type 2 diabetes mellitus." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1157551296.
Full textWinnick, Jason J. "Effect of aerobic exercise on peripheral glucose uptake and endogenous glucose production in type 2 diabetes mellitus." The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1157551296.
Full textPidduck, Clare. "Studies of the effect of glucose on insulin-secreting cells." Thesis, University of Leicester, 1987. http://hdl.handle.net/2381/35128.
Full textDuwaihy, Mansour Mohammad. "Effect of dietary fat on glucose tolerance in the rat." Thesis, University of Surrey, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326901.
Full textTabidi, I. "The effect of glucose on cardiac AMP-activated protein kinase." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18944/.
Full textVo, Annie Phuong. "Glucose Metabolism in Cancer-Associated Fibroblasts." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11025.
Full textKawano, Yuichi. "Effect of hyperglycemia on glucose transport and intracellular signal transduction in skeletal muscle /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3593-9/.
Full textPeshdary, Vian. "Effect of Glucose on Human Adipogenesis and its Regulation by Macrophages." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35051.
Full textOenzil, Fadil, and mikewood@deakin edu au. "Effect of vitamin A deficiency on glucose uptake in the rat." Deakin University. School of Science, 1988. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20051110.120816.
Full textYang, Yi. "The effect of high glucose on APP metabolism and Abeta production." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44189.
Full textChristian, Leonie Marie. "The effect of glucose on memory and aspects of cognitive function." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541645.
Full textBradley, Helen Elizabeth. "Glucose transporter 4 and localisation in skeletal muscle : the effect of glucose and insulin administration, acute exercise and exercise training." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/4832/.
Full textDuffner, Jack Patrick. "Synthesis of Benzimidazolone Glucose Uptake Inhibitors." Ohio University Honors Tutorial College / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1524832705752963.
Full textMartino, Paul F. "The effects of dantrolene on post exercise glucose uptake." Virtual Press, 1996. http://liblink.bsu.edu/uhtbin/catkey/1020145.
Full textSchool of Physical Education
Clark, Louise Frances. "The effect of long-term high-dose n-3 PUFA on glucose and protein metabolism in subjects with impaired glucose regulation." Thesis, University of Aberdeen, 2012. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=192307.
Full textWilkinson, Ryan John Paul. "Effect of glucose on the suppression and post-suppression rebound of stereotypes." Thesis, University of Canterbury. Psychology, 2011. http://hdl.handle.net/10092/6213.
Full textStone, Claire Gemma. "Antioxidants and trace elements : effect on mediated electron transfer in glucose biosensors." Thesis, University of Surrey, 2006. http://epubs.surrey.ac.uk/763/.
Full textMetcalf, J. A. "The effect of insulin on glucose metabolism during lactation in the ewe." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378850.
Full textKuma, Bezawit G. "The Effect of Hatha Yoga on Glucose Levels in Healthy College Students." Ohio Dominican University Honors Theses / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=oduhonors1462292094.
Full textMannan, Adnan. "Molecular Signaling Pathways Involved in the Glucose-Lowering Effect of Teucrium polium." Thesis, Curtin University, 2017. http://hdl.handle.net/20.500.11937/56434.
Full textDiLeo, Jessica, Michaela Johnson-Clague, Jennifer Prze, and Asad Patanwala. "Effect of Blood Glucose in the Emergency Department on Hospital Length of Stay." The University of Arizona, 2013. http://hdl.handle.net/10150/614255.
Full textSpecific Aims: The objective of this study is to evaluate the effect of early blood glucose correction in the Emergency Department (ED) on hospital length of stay. Methods: This study has received institutional review board approval. This is a retrospective cohort study conducted in an academic medical institution. Diabetic patients with hyperglycemia in the ED between June 1st, 2011 and June 30th, 2012 were included. Patients were excluded if they were less than 18 or greater than 89 years of age, not admitted, had diabetic ketoacidosis or hyperglycemic hyperosmolar state, treated with insulin for hyperkalemia, trauma patients, or had an initial blood glucose value of 200 mg/dL or less. Patients were categorized into two groups based on blood glucose control achieved within the first 24 hours from triage. The primary outcome of this study was to compare hospital length of stay between the groups. Main Results: A total of 161 patients were included in this study. Baseline demographics between groups were statistically similar with the exception of gender (p=0.635), ethnicity (p = 0.149), and co-morbidities calculated by the Charlson Co-Morbidity Score (p = 0.112). Blood glucose values in the ED did not statistically correlate to hospital length of stay (p = 0.299), however, co-morbidities were predictive of hospital length of stay (p = 0.025). Conclusion: Early correction of blood glucose values in the ED are not associated with hospital length of stay.
Karamichalis, Nikolaos. "Using Machine Learning techniques to understand glucose fluctuation in response to breathing signals." Thesis, Luleå tekniska universitet, Institutionen för system- och rymdteknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-87348.
Full textStruble, Nigel. "Measuring Glycemic Variability and Predicting Blood Glucose Levels Using Machine Learning Regression Models." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1382664092.
Full textWhite, Lynn H. "Task-specific effects of glucose and stress on memory." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ44628.pdf.
Full textRoberts, Dennis A. "Design and Synthesis of Stable Glucose Uptake Inhibitors." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou14791141897033.
Full textMiniaci, Sandra A. "Maternal dietary glucose restriction and its effect on amniotic fluid amino acid composition." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0001/MQ44224.pdf.
Full textForouzandehfard, Farnaz. "Effect of formulation parameters on the stability of glucose oxidase from Aspergillus niger." Thesis, University of Kent, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633691.
Full textSimpson, Charles H. A. "Effect of glucose solutions on fluid availability at rest and exercise in humans." Thesis, University of Aberdeen, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424992.
Full textMcDonnell, Barry John. "The effect of diabetes, ethnicity, impaired fasting glucose and exercise on arterial stiffness." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/54056/.
Full textYoung, Hayley Anne. "The effect of postprandial glucose metabolism on cognition and mood across the lifespan." Thesis, Swansea University, 2013. https://cronfa.swan.ac.uk/Record/cronfa43174.
Full textShah, Dhruvesh. "Effect of Glucose Supplementation on Nighttime Biomass Loss and Productivity of Microalgae Chlorella." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1337627039.
Full textStahl, Rachel. "The Effect of Glucose on Beta-Catenin Expression in Diabetic and Normal Cells." Marietta College Honors Theses / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=marhonors1496139881597792.
Full textLai, Ya-Chi, and 賴雅琪. "Effect of catechins on learning memory ability, antioxidative status, blood glucose and insulin in senescence accelerated mice." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/a39kan.
Full text靜宜大學
食品營養研究所
94
Catechins were demonstrated to have antioxidant and redusing blood glucose capacity. The purpose of this study was to investigate the effect of catechins on learning and memory ability, antioxidative status, blood glucose and insulin content in senescence accelerated mice. 3- and 6-month-old senescence accelerated male and female mice were divided into four groups: control group, 50, 200 and 800 ppm aqueous solutions of catechins(experimental groups). After 12 weeks of feeding, body weight, food intake, drink amount, aging score, open field activity test, single-trial passive avoidance and active shuttle avoidance test were performed during the experiment. The oral glucose tolerance test (OGTT) was analyzed before sacrificed. The biochemical parameters of serum were analyzed after sacrificed. The activity of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase, glucose-6-phosphate dehydrogenase (G-6-PD), malondialdehyde (MDA) , protein carbonyl and total thiol concentrations and insulin content, pathological examination of brain and pancreas. The results showed that there were no significant differences in the body weight, food intake, drink amount and locomotion among four groups. The aging score of experimental groups were significantly lower than the control group in the 3-and 6-month-old mice (p<0.05). In learning and memory test, experimental groups of 3-and 6-month-old senescence accelerated male and female mice had significantly better in active shuttle avoidance response and single-trial passive avoidance test (p<0.05). The results of OGTT, experimental groups of 3-and 6-month-old senescence accelerated male and female mice had significantly lower than the control group on blood glucose at 0, 30, 60, 90, 120 minutes (p<0.05). In concentration of plasma insulin, experimental groups had significantly lower than the control group in before and 30, 60, 90, 120 minutes (p<0.05). The SOD activity was no significantly different in both 3-and 6-month old male and female mice. The catalase, GPx, glutathione reductase, G-6-PD activity and total thiol concentration, experimental groups of 3-and 6-month-old senescence accelerated male and female mice had significantly higher than the control group (p<0.05). The MDA and protein carbonyl concentrations in the experimental groups were significantly lower than the control group. The β-amyloid protein deposition of brain, pancreas and insulin content were no significantly different in the 3-and 6-month male and female mice. From the findings of these results, the supplement of catechins may ameliorate learning and memory ability, antioxidative system and increase insulin sensitivity in SAMP8 mice.
Chen, Yu-chung, and 陳昱均. "Effect of Aminoguanidine on Glucose Homeostasis." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/83841878157645674084.
Full text國立成功大學
藥理學研究所
97
Diabetes is a metabolic disorder, characterized by impaired glucose utilization and high plasma glucose, lots of complications might be developed by diabetes. It was reported that aminoguanidine (AMG) inhibited advanced glycation end product formation to improve the development of diabetic complications. However, the direct effect of AMG on glucose homeostasis remains unclear. In this study, hypoglycemic effect was observed in Wistar rats and streptozotocin-induced type I diabetic rats (STZ-diabetic rats) after AMG injection. On the other hand, AMG treatment increased glucose tolerance in Wistar rats, indicating that the glucose-lowering action of AMG might increase plasma insulin levels or glucose utility. In the present study, the plasma insulin level of Wistar rats was increased after AMG treatment, whereas AMG had no effect on glucose uptake in mouse myoblast cells (C2C12). Also, the loperamide-induced glucose uptake was inhibited by AMG treatment in vitro. Thus, the hypoglycemic effect of AMG in STZ-diabetic rats and Wistar rats seems through the AMG metabolites. Previous studies had been shown that AMG metabolites act as agonists at the nicotinic cholinoceptor. Activation of nicotinic cholinoceptor might induce acetylcholine release and further activated muscarinic cholinoceptor and several studies had shown that muscarinic M1 recepter plays a role of glucose uptake into C2C12 cells and insulin secretion. We found that the hypoglycemic action and insulinotropic effect of AMG in experimental rats was blocked by nicotinic cholinoceptor antagonist (hexamethonium) and muscarinic cholinoceptor antagonist (atropine or pirenzepine). Physostigmine at concentration sufficient to inhibit acetylcholinesterase enhanced the hypoglycemic action of AMG in Wistar rats and STZ-diabetic rats. Taken together, these results suggest that AMG has an ability to decrease blood glucose in diabetic rats and normal rats, probably through AMG metabolites to activate cholinergic neurotransmission.
Ling, Sheng-Ming, and 凌聖銘. "Effect of central insulin on glucose homeostasis." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/49720169215328737452.
Full text國立成功大學
藥理學研究所
96
Central administration of insulin has metabolic, reproductive and neurotrophic effects. The metabolic effects of insulin are responsible for controlling the long-term glucose homeostasis via an activation of parasympathetic nerves in peripheral, which results in reduction of hepatic glucose output. However, it is still unclear whether central insulin exerts the regulation of plasma glucose within short term. In this study, we found that central administration of insulin caused an increment of plasma insulin level and a counterpart decrement in plasma glucose level within one hour. These effects were blocked by vagotomy and intraperitoneal administration of 4-DAMP, a specific M3 antagonist, which points out the importance of vagus nerve in insulin release and plasma glucose lowering effect. KATP is a key mediator in central signaling pathway of insulin. We also found that plasma glucose-lowering effect was blocked by central administration of sulphonylurea, a KATP blocker. After investigation the opposing effect of sulphonylurea to central effect of insulin, we found that the anorexic effect of central insulin is abolished after peripheral administration of sulphonylurea. Administration of sulphonylurea for 7 days results in diminished plasma glucose-lowering effect of central insulin. In conclusion, central insulin decreased plasma glucose level by activation of vagus nerve, which resulted in release of insulin, and intraperitoneal administration of sulphonylurea interferes with central effect of insulin.
Chen, Kuan-yu, and 陳冠宇. "Effect of glucose metabolism on recombinant protein production." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/26qg8h.
Full text逢甲大學
生醫資訊暨生醫工程碩士學程
102
An Escherichia coli strain that expresses the T7 RNA polymerase under the control of L-arabinose has been developed in our lab. However, this bacterial strain is deficient in the glucose transporter gene of the phosphotransferase transport system, which leads to the impaired glucose metabolism of the strain. In this study, the approach of metabolic engineering was adopted to improve glucose metabolism of this bacterial strain. The performance of this resulting strain for recombinant protein production was further investigated.
Huang, Chiung-Yu, and 黃炯毓. "Effect of Glucose Injection on Blood Glucose and Glycosuria for Tilapia(Oreochromis niloticus × O. aureus)." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/35881882636994240956.
Full text國立海洋大學
水產養殖學系
87
Fishes appear to utilize dietary carbohydrate poorly. It has been shown that carbohydrate is generally the major dietary source of energy in most domestic animals, however, it is considered to be of limited value in the nutrition of fish. Differences in carbohydrate digestion、utilization、absorption and metabolism between fish and mammals the major reasons. Causing dietary differences between these two animal groups. The objective of this experiment was to observe the variation of the blood glucose and glycosuria concentration within 24 hours after each injection of a certain glucose concentration in order to determine the glucose threshold for tilapia.The experiment 1, four levels of glucose concentrations 0, 0.75, 1.05, 1.35 g/dl had been injected, according to the body weight of tested fish. Experiment was designed be find threshold value of blood glucose for tilapia. The experiment 2, four levels of glucose concentrations 15, 22.5, 30, 45 g/dl had been injected. The second experimented was to understand the glucose of blood glucose and glycosuria after high concentration glucose injection.The result of experiment 1 indicates that the threshold of glucose in tilapia urine is at 87.25 mg/dl. The maximum glucose emission at the second hour after the injection of 15, 22.5, 30 g/dl glucose levels in second experiment. However, 45 g/dl level, the maximum glucose emission is at the first hour. The results of second experiment also indicate that the percentage of emission/injection decreased with the increasing of the injection concentration. Furthermore, the experiment 2 also show that 95% glucose inject to fish were not excreted to urine or keep in fish body.
Ribeiro, Ana Clara Sampaio. "Evaluation of the pre-analytical factors effect in the blood glucose concentration determination and iatrogenic hyperglycemia effect on leukogram values." Master's thesis, 2020. http://hdl.handle.net/10348/9931.
Full textThere are recommendations specific for measuring blood glucose in serum or plasma and in both cases, it is very important that the samples be centrifuged for the separation of serum or plasma from blood cells, up to 1 hour postcollection. This is important because glycolysis continues in the in vitro blood cells. In veterinary medicine, although delays between blood collection and analysis are common, in the bovine species, the effect of prolonged contact with the clot in the glucose concentration is not well established. The use of supplemented fluids with glucose is a common procedure and to date there is no published papers about the effect of spurious hyperglycemia in the leucocyte count in dogs and cats. Thus this dissertation has two main objectives: to evaluate the glucose levels in paired samples of serum, plasma and fluoridated plasma belonging to bovine animals, in order to elucidate the effect of storage time and temperature in glucose concentration and, to formulate specific recommendations for sample storing and processing; to evaluate spurious hyperglycemia effect on the leucocyte cell count (total and differential count) in dog and cat blood with the ProCyte Dx hematological Analyzer (IDEXX). For the first objective, the total blood samples were divided into tubes without additive, Fluoride/EDTA tubes and heparin lithium tubes. Samples were stored ate 25ºC and 4ºC and glucose concentration was determined 2h, 4h, and 8h after collection by on an automated biochemistry analyser (Randox RX Daytona™). The results suggest that the mean concentration of glucose in the fluoridated plasma is not statistically different for both storage temperatures. In serum, the mean glucose concentration is statistically different when the samples are stored at 4ºC or at 25ºC. For plasma, the reduction in the mean concentration of glucose at 4 ºC or at 25ºC is not significant. The mean glucose concentration in the fluoridated plasma sample is not statistically different for the four post-harvest dosing times whereas for the serum and plasma samples, the average glucose concentration will decrease over time. We conclude that the total blood storage at 4ºC limits the decline in glucose concentration by up to 8 hours of storage in fluoridated plasma samples. Storage exceeding 4 hours, even at 4ºC, should be avoided in serum and plasma samples to avoid significant changes in glucose concentration. At 25ºC, the contact time of the serum clot should not exceed 1 hour in serum and plasma samples and 2 hours in fluoridated plasma samples. For the second objective, dog and cat blood samples were collected for EDTA tubes. The samples were experimentally "contaminated" with glucose to achieve a final concentration of 5%, 10% and 20% and were analysed in the ProCyte Dx ™ (IDEXX). Any spurious hyperglycemia group don’t show statistical significant difference from hemodilution group. These results are observed both in dogs and cats. We can conclude that apparently spurious hyperglycemia has no effects in the leucocytes parameters.
Existem recomendações específicas para medir a glicose no sangue no soro ou plasma e, em ambos os casos, é muito importante que as amostras sejam centrífugas para a separação do soro ou plasma das células sanguíneas, até 1 hora após a coleta. Isto é importante porque a glicólise continua nas células sanguíneas in vitro. Na medicina veterinária, embora sejam comuns os atrasos entre a colheita e a análise de sangue, nas espécies bovinas, o efeito do contato prolongado com o coágulo na concentração de glicose não está bem estabelecido. O uso de suplementos líquidos com glicose é um procedimento comum e, até o momento, não há artigos publicados sobre o efeito da hiperglicemia espúria na contagem de leucócitos em cães e gatos. Assim, esta dissertação tem dois objetivos principais: avaliar os níveis de glicose em amostras pareadas de soro, plasma e plasma fluoretado pertencentes a bovinos, a fim de elucidar o efeito do tempo e temperatura de armazenamento na concentração de glicose e, formular recomendações específicas para armazenamento e processamento de amostras; avaliar o efeito da hiperglicemia espúria na contagem de células leucocitárias (contagem total e diferencial) no sangue de cães e gatos com o Analisador Hematológico ProCyte Dx (IDEXX). Para o primeiro objetivo, as amostras totais de sangue foram divididas em tubos sem aditivo, tubos de fluoreto/EDTA e tubos de heparina lítio. As amostras foram armazenadas a 25ºC e 4ºC e a concentração de glicose foi determinada 2h, 4h e 8h após a colheita num analisador bioquímico automatizado (Randox RX Daytona ™). Os resultados sugerem que a concentração média de glicose no plasma fluoretado não é estatisticamente diferente para as duas temperaturas de armazenamento. No soro, a concentração média de glicose é estatisticamente diferente quando as amostras são armazenadas a 4ºC ou a 25ºC. Para o plasma, a redução na concentração média de glicose a 4ºC ou a 25ºC não é significativa. A concentração média de glicose na amostra de plasma fluoretado não é estatisticamente diferente nos quatro tempos de dosagem pós-colheita, enquanto nas amostras de soro e plasma, a concentração média de glicose diminui com o tempo. Concluímos que o armazenamento total de sangue a 4ºC limita o declínio na concentração de glicose até 8 horas em amostras de plasma fluoretado. O armazenamento superior a 4 horas, mesmo a 4ºC, deve ser evitado em amostras de soro e plasma para evitar alterações significativas na concentração de glicose. A 25ºC, o tempo de contato do coágulo sérico não deve exceder 1 hora nas amostras de soro e plasma e 2 horas nas amostras de plasma fluoretado. Para o segundo objetivo, amostras de sangue de cães e gatos foram colhidas para tubos de EDTA. As amostras foram "contaminadas" experimentalmente com glicose para atingir uma concentração final de 5%, 10% e 20% e foram analisadas no ProCyte Dx ™ (IDEXX). Qualquer grupo de hiperglicemia espúria não mostra diferença estatística significante em relação ao grupo de hemodiluição. Estes resultados são observados em cães e gatos. Podemos concluir que a hiperglicemia aparentemente espúria não tem efeitos nos parâmetros dos leucócitos.
Gin-Chi, Huang, and 黃靖琪. "Effect of Canavanine on Plasma Glucose in Diabetic Rats." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/63885018091993873451.
Full text國立成功大學
藥理學研究所
96
Several studies have been demonstrated that the guanidine-derivative compound has a potent effect on decreasing the plasma glucose via imidazoline subtype 2 receptor (I2R) or increasing the secretion of insulin via imidazoline subtype 3 receptor (I3R). Canavanine, belongs to one of the guanidine derivatives, is one of the active ingredient extracted from Sutherlandia frutescens and Medicago sativa. The present study aimed to clarify whether canavanine exerted the hypoglycemic effect through activating IR. In normal rats, canavanine decreased the blood glucose in a dose-dependent manner. In streptozotocin-induced diabetic rats, canavanine lowered the plasma glucose and increased ��-endorphin, which were abolished by pretreatment the rats with BU224 at the dose sufficient to block I2R. Canavanine also dose-dependently increased the glucose uptake in isolated skeletal muscle, which was blocked by BU224. Moreover, we used C2C12 skeletal myoblast cells to verify whether canavanine augmented the glucose uptake ability via I2R. Results showed that canavanine dose-dependently increased the glucose uptake in C2C12 cells, whereas this effect was blocked by both BU224 and amiloride (an I2A blocker). Several studies indicated that the phosphorylated AMPK (pAMPK) raises expression of glucose transporter 4 (Glut4), leading to the increase of glucose uptake. We also employed Western blotting analysis to detect the effect of canavanine on AMPK phosphorylation and Glut4 expression. These results revealed that canavanine enhanced the levels of pAMPK and Glut4 expression in C2C12 cells, which were abolished by BU224, amiloride and compound C (an AMPK inhibitor). Furthermore, canavanine produced an insulinotropic action in normal rats. An increase of insulin release was observed by canavanine in HIT-T15 cells, a pancreatic islet ��-cell, whereas this effect was blocked by I3R antagonist, KU 14 R. Finally, we also found that canavanine not only increased the ability on glucose utilization but also improved the insulin sensitivity determined by glucose tolerance test, insulin tolerance test and HOMA-IR. Taken together, these results suggested that canavanine produced hypoglycemic action through both I2R in insulin-independent and I3R in insulin-dependent pathways and implicated that it might be beneficial effect for both type 1 and type 2 diabetes.
Wang, Yung-Hsuan, and 王詠萱. "Effect of Longan Flower Extract on Blood Glucose Regulation." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/03416129735391144799.
Full text中原大學
生物科技研究所
100
Diabetes mellitus (DM) is a chronic disease characterized by elevated levels of sugar in the blood. It's one of the prevalent diseases of modern times. DM not only list on the "top ten causes of death" in Taiwan, but also the prevelence rate of it increasing, accompanied with a decreasing average age of incidence annually. In addition, DM would also induce other complication diseases, for example coronary heart disease, renal disease and hypertention. Apparently, DM is a significant disease for people in Taiwan. Our previous study showed that water extract of longan flower (LF) could ameliorate the multiple symptoms in metabolic syndrome (MS). MS frequently occurs in people with DM. Therefore, the aim of this study was to further examine if the longan flower could improve DM and the complication of DM. The first part of this study is an animal study. Nicotinamide and streptozotocin-induced type 2 diabetic Sprague-Dawley rats were used as a animal model. Rats were administered with water extracts of longan flower (LF), ethyl acetate fractions of LF (EA) and water layer fractions of LF (W) respectly to evaluate the hypoglycemic effect of LF and its different fractions. Following, the assay of glucose/dicarbonyl compound induced formation of advanced glycation end products were used to assess the preventing effects of LF and its different fractions on diabetic complication. Results of in vivo study showed that EA fraction could improve the hyperglycemia and hypertriglyceridemia in diabetes rats. And also, LF and EA fraction ameliorated the glucose intolerance which is considered to be a stage in the development of type 2 DM. Results of in vitro study showed that LF could inhibit the formation of advanced glycation end product, and the most effective fraction was EA fraction.
Wu, Chen-Pei, and 吳佩蓁. "Effect of Kefir on Glucose Uptake in Skeletal Muscle." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/08509041042319979612.
Full text國立臺灣大學
食品科技研究所
103
Diabetes mellitus (DM) is a predominant chronic disease which causes mortality of millions of people yearly. Insulin resistance is a key etiology of Type 2 DM. Kefir is a fermented milk which composed a specific mixture of bacteria and yeast cultures, and have received increasing attention as potential ingredients of health-promoting functional foods. Past studies revealed that kefir can improve diet-related chronic diseases, such as obesity, systemic inflammation, hyperglycemia, hypercholesterolemia and type 2 DM, but the exact mechanism is still unknown. In our study, a free fatty acid induced insulin resistant cell model was first established. We found that when pH is higher than 4.5, the lactic acid bacteria and the yeast in kefir could help each other grow up steadily. With longer fermentation time the glucose uptake activity of L6 cell became higher and along with dose response. According to results of ultrafiltration (1 kDa), it indicated that the active compound might be small molecular protein and peptide. The water extract compound from 12 hours and 96 hours fermentation under 37℃ not only activated AMPK signaling molecules, but also PI3K signaling molecules to induce GLUT4 translocation. The water extract compound from 12 hours and 24 hours fermentation of traditional kefir and 24 hours fermentation under 37℃ primary activated PI3K signaling molecules, the signaling molecules pathway is similar with insulin. The water extract compound from 96 hours fermentation of traditional kefir primary activated AMPK signaling molecules. Furthermore, the water crude extracts was fractionated by anion-exchange chromatography. It was found that the fraction 5 of co-culture kefir at 37℃ has high glucose uptake activity, and it both activated AMPK and PI3K signaling molecules to induce GLUT4 translocation.
Su, Jia-Lung, and 蘇家龍. "Effect of blood glucose on the cervical epithelial pathogenesis." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/pbn88c.
Full text中山醫學大學
醫學研究所
106
Normal cervical epithelial cells undergo a series of cell differentiation before they change to cervical cancer. Type 2 diabetes is known to be associated with an increased incidence of cervical cancer and mortality; however, it is unclear whether hyperglycemia is associated with lesions of cervical epithelial cells. This study was a hospital-based retrospective generation study that analyzed 3,937 subjects with Pap smear and biopsy data from January 1, 2011 to December 31, 2017. During the study period, all subjects underwent at least two Pap smear tests; abnormality rate in the first smear test was 12.9%, and abnormality rate in the second smear test increased to 16.2%. The proportions in subjects with abnormalities in the first smear examination that were further determined by the biopsy to be cervical intraepithelial neoplasia-1 (CIN1), CIN2, and CIN3 were 41.1%, 11.6%, and 2.9%, respectively. The proportions in subjects with abnormalities in the second smear examination that were further determined by the biopsy to be CIN1, CIN2, and CIN3 increased to 46.7%, 21.8%, and 4.9%, respectively. Moreover, after adjusting for the effects of confounding factors, compared to the subjects with normal fasting blood glucose, those with fasting blood glucose 100-125 mg/dL (odds ratio [OR] = 1.47, 95% confidence interval [C.I.] = 1.00-2.16) and >= 126 mg/dL showed a significantly higher risk in the deterioration of epithelial cell (OR = 1.85, 95% C.I. = 0.99-3.45), respectively. Therefore, blood glucose may be an important factor affecting the development of cervical precancerous lesions.
Chen, Yan-jing, and 陳妍菁. "Effect of Glucose and Glycerol Metabolism on Recombinant Protein Production." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/az34rn.
Full text逢甲大學
化學工程學系
102
Protein synthesis in living cells is an energy-dependent process. Accordingly, the level of protein production is closely related to the energy status of cells. In this study, we enhanced glucose and glycerol metabolism in Escherichia coli. The experimental results showed that the engineered strain performed better than its non-modified counterpart in terms of growth and the production yield of recombinant proteins. It clearly indicates that this proposed approach is promising to improve the physiological trait of producer strains for recombinant protein production.
Liao, Chun-Huei, and 廖純慧. "Study on the glucose intolerance effect of oxidized frying oil." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/34475078450854538808.
Full text中國醫藥大學
營養學系碩士班
95
We had previously found that dietary oxidized frying oil (OFO)could decrease body fat and induce glucose intolerance in the rats and mice. The aim of this study was to investigate the mechanism of OFO induced glucose intolerance in mice. Experiment 1 was designed for comparing the OFO effect with the conjugated linoleic acid (CLA) induced lipodystrophy diabetes . 51 C57BL/6J mice were divided into five groups. In order to observe the lipodystrophy diabetes induced by CLA, LF and the CLA group were set, to receive a diet containing 4% (g/g) fresh soybean oil (LF)and LF diet plus 1% CLA mixture(c9,t11:t10,c12=1:1), respectively. In order to observe the effect of OFO, HF, FO and the HO group were set, to receive a diet containing 20% fresh soybean oil (HF), 10% fresh soybean oil plus 10% OFO (FO)and 20% OFO (HO), respectively. The OFO was prepared by frying wheat dough sheets in soybean oil at 205 ± 5 ℃ for 24 hours. After 4 weeks, mice were killed after an overnight fasting. The results showed the CLA diet could reduce the energy efficiency and the white adipose deposition more prominant than the OFO diet. Both diets(CLA and OFO)could result in liver enlargement. The both diets could also reduce the serum levels of triglyceride and free fatty acids, but the CLA diet caused an increase in the serum levels of total lipid and cholesterol. In contrast, the OFO diet caused a reduction in the serum levels of total lipid and the cholesterol. Moreover, the CLA diet resulted in the accumulation of triglyceride and cholesterol in liver seriously. However, the OFO diet resulted in an up-regulation of PPAR alpha target gene-ACO and the liver triglyceride was significantly reduced by OFO diet, which could be attributed to the increase of fatty acid oxidation and suppression of fatty acid synthesis in the liver. For understanding the two diets effect on adipocyte differentiation, lipogenesis and production of adipocytokines, mRNA levels of peroxisome proliferators-activated receptor gamma 2(PPARγ2), lipoprotein lipase(LPL), fatty acid synthase(FAS)and leptin were measured by real time PCR. Results showed the expression of PPAR gamma 2, LPL, FAS and leptin in adipose tissues were greatly reduced by dietary CLA, indicating a serious suppression on the adipocyte differentiation and lipogenesis. Adipocyte apoptosis were demonstrated by DNA ladder in the CLA diet group. The expression of PPAR gamma 2, LPL and leptin were only slightly reduced by OFO diet , indicating that the OFO diet, unlike the CLA diet, didn’t suppress the adipocyte differentiation and the lipogenesis so prominat as CLA diet and the adipocyte apoptosis was not observed in OFO diet group. About the insulin sensitive, an ITT was conducted at wk2, and the AUCglu showed the CLA group had a significant higher level than the LF group(p<0.05), demonstrating the peripheral insulin resistance was happened in CLA group, but the AUCglu in the HO group was significantly lower than that in the HF group(p<0.05). In addition, an OGTT was conducted at wk4 and the AUCglu showed the HO group had a significantly higher level than the HF group(p<0.05), demonstrating the glucose intolerance was happened in the OFO group, but not the CLA group. The CLA group also showed a significantly higher blood sugar and the insulin levels at feeding status, but HO group had a significantly lower blood insulin level than the HF group. Therefore, the mechanism of OFO diet induced glucose metabolism impairment is different from the CLA diet, which is not insulin resistance, but an impairment in insulin secretion from pancreas is involved. As the hypoinsulinemia was observed in the OFO group, to explore the possibility of destruction of pancreas beta cells and the impairment of insulin secretion, experiment 2 was conducted. 32 C57BL/6J mice were divided into three groups, to receive a diet containing 4% (g/g)fresh soybean oil (LF), 20% fresh soybean oil (HF) or OFO (HO), respectively. After 24 weeks, mice were killed at feeding status. The blood sugar, serum insulin and the C-peptide were measured simultaneously during an OGTT. Results showed the HO group had a significantly higher blood sugar, but the serum insulin and C-peptide were significantly lower than the other two groups, demonstrating HO group did cause pancreas beta cell destroy and result in the insulin secretion insufficiency. The analysis of vitamin E in liver and pancreas demonstrating vitamin E deficiency was observed in the HO group. In conclusion, our results showed OFO causes the glucose intolerance in mice, which is different from the CLA caused lipodystrophy diabetes. It is well-know that CLA induced lipodystrophy diabetes had characterstic of peripheral insulin resistance, and hyperinsulinemia was observed in CLA-fed mice. This study demonstrated that the glucose intolerance induced by the HO diet is not related with the peripheral insulin resistance, but the pancreas destruction and insulin secretion insufficiency is the main reason. The possibility of pancreas peroxidation, the inflammation, or vitamin E deficiency might be involved.