Journal articles: 'Lead (II) compounds'

1

Jones, Jamie N., and Alan H. Cowley. "π-Indenyl tin(ii) and lead(ii) compounds." Chem. Commun., no. 10 (2005): 1300–1302. http://dx.doi.org/10.1039/b410549d.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Wang, Yin, Yanjiao Xie, Wenlu Li, Zimeng Wang, and Daniel E. Giammar. "Formation of Lead(IV) Oxides from Lead(II) Compounds." Environmental Science & Technology 44, no. 23 (December 2010): 8950–56. http://dx.doi.org/10.1021/es102318z.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Harrowfield, JM, H. Miyamae, BW Skelton, AA Soudi, and AH White. "Lewis-Base Adducts of Lead(II) Compounds. XVI. Synthetic and Structural Studies of Some Adducts of 2-Aminomethylpyridine With Lead(II) Compounds." Australian Journal of Chemistry 49, no. 10 (1996): 1127. http://dx.doi.org/10.1071/ch9961127.

Full text

Abstract:

Syntheses and room-temperature single-crystal X-ray structure determinations are recorded for 2:1 adducts of 2-aminomethylpyridine ('amp') with lead(II) nitrate and thiocyanate . [(amp)2Pb(NO3)2]2 is triclinic, Pī, a 11.616(4), b 11.145(6), c 7.341(3) Ǻ, α 83.87(4), β 89.17(3), γ 64.12(3)°, Z = 1 dimer ; R was 0.043 for No 3529 independent 'observed' (I > 3σ(I)) reflections. [(amp)2Pb(SCN)2]2 is also triclinic, Pī , a 12.121(9), b 9.301(14), c 8.615(8) Ǻ, α 70.11(10), β 84.00(7), γ 79.38(10)°, Z = 1 dimer (R 0.033 for No 3467). Both complexes are centrosymmetric dimers ; the coordination environment is made up in each case of a pair of N,N°-bidentate bases, one terminally bound anion (O,O°-chelating nitrate or S-bonded thiocyanate ) and bridging anions. In the case of the thiocyanates, these bridge end-on, so that the lead(II) environment is seven-coordinate PbN5S2; in the nitrate, the anion chelates through two of its oxygen atoms, bridging via the third, so that the lead(II) environment is nine-coordinate PbN4O5. A 'problem structure', [(amp)2Pb(ClO4)2], monoclinic, C2/c (?), a 14.528(3), b 8.203(3), c 15.495(6) Ǻ, β 91.14(3)°, Z = 4 f.u ., R 0.044 for No 1775, is also recorded, the crystal seemingly a disordered aggregate of [(N, N′-amp)2Pb(OClO3)2] moieties.

APA, Harvard, Vancouver, ISO, and other styles

4

Han, Kyoung R., Hee Jin Koo, and Chang Sup Lim. "Novel Route to Lead-Based Ferroelectric Compounds via Tetragonal Lead(II) Oxide Intermediates." Journal of the American Ceramic Society 83, no. 9 (December 20, 2004): 2214–18. http://dx.doi.org/10.1111/j.1151-2916.2000.tb01537.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Bowes, Scott, Dongyu Sun, Azita Kaffashan, Chenhui Zeng, Claudio Chuaqui, Xiaoping Hronowski, Alex Buko, Xin Zhang, and Serene Josiah. "Quality Assessment and Analysis of Biogen Idec Compound Library." Journal of Biomolecular Screening 11, no. 7 (September 14, 2006): 828–35. http://dx.doi.org/10.1177/1087057106290993.

Full text

Abstract:

A subset of the compound repository for lead identification at Biogen Idec was characterized for its chemical stability over a 3-year period. Compounds were stored at 4 °C as 10 mM DMSO stocks, and a small subset of compounds was stored as lyophilized dry films. Compound integrity of 470 discrete compounds (Compound Set I) and 1917 combinatorial chemistry-derived compounds (Compound Set II) was evaluated by liquid chromatography/mass spectrometry from the time of acquisition into the library collection and after 3 years of storage. Loss of compound integrity over the 3 years of storage was observed across the 2 subsets tested. Of Compound Set I, 63% of samples retained > 80% purity, whereas 57% of samples from Compound Set II had purity greater than 60%. The stability of the lyophilized samples was superior to the samples stored as DMSO solution. Although storage at 4 °C as DMSO solution was adequate for the majority of compounds, the authors observed and quantified the level of degradation within the compound collection. Their study provides general insight into compound storage and selection of library subsets for future lead identification activities.

APA, Harvard, Vancouver, ISO, and other styles

6

Mbuyazi, Thandi B., and Peter A. Ajibade. "Bis(4-methylpiperidine-1-carbodithioato)-lead(II) and Bis(4-benzylpiperidine-1-carbodithioato)-lead(II) as Precursors for Lead Sulphide Nano Photocatalysts for the Degradation of Rhodamine B." Molecules 26, no. 23 (November 29, 2021): 7251. http://dx.doi.org/10.3390/molecules26237251.

Full text

Abstract:

Bis(4-methylpiperidine-1-carbodithioato)-lead(II) and bis(4-benzylpiperidine-1-carbodithioato)-lead(II) were prepared and their molecular structures elucidated using single crystal X-ray crystallography and spectroscopic techniques. The compounds were used as precursors for the preparation of lead sulphide nano photocatalysts for the degradation of rhodamine B. The single crystal structures of the lead(II) dithiocarbamate complexes show mononuclear lead(II) compounds in which each lead(II) ion coordinates two dithiocarbamato anions in a distorted tetrahedral geometry. The compounds were thermolyzed at 180 ℃ in hexadecylamine (HDA), octadecylamine (ODA), and trioctylphosphine oxide (TOPO) to prepare HDA, ODA, and TOPO capped lead sulphide (PbS) nanoparticles. Powder X-ray diffraction (pXRD) patterns of the lead sulphide nanoparticles were indexed to the rock cubic salt crystalline phase of lead sulphide. The lead sulphide nanoparticles were used as photocatalysts for the degradation of rhodamine B with ODA-PbS1 achieving photodegradation efficiency of 45.28% after 360 min. The photostability and reusability studies of the as-prepared PbS nanoparticles were studied in four consecutive cycles, showing that the percentage degradation efficiency decreased slightly by about 0.51–1.93%. The results show that the as-prepared PbS nanoparticles are relatively photostable with a slight loss of photodegradation activities as the reusability cycles progress.

APA, Harvard, Vancouver, ISO, and other styles

7

Akbari Afkhami, Farhad, Ghodrat Mahmoudi, Fengrui Qu, Arunava Gupta, Muhammet Köse, Ennio Zangrando, Fedor I. Zubkov, Ibon Alkorta, and Damir A. Safin. "Supramolecular lead(ii) architectures engineered by tetrel bonds." CrystEngComm 22, no. 13 (2020): 2389–96. http://dx.doi.org/10.1039/d0ce00102c.

Full text

Abstract:

The structures, including tetrel bonding, of Pb^II coordination compounds assembled from N′-(pyridin-2-ylmethylene)picolinohydrazide, N′-(pyridin-2-ylmethylene)nicotinohydrazide and N′-(1-(pyridin-2-yl)ethylidene)isonicotinohydrazide ligands are discussed.

APA, Harvard, Vancouver, ISO, and other styles

8

Bhattacharya, Sagarika, and Sasankasekhar Mohanta. "Heterometallic copper(II)–lead(II), nickel(II)–lead(II) and copper(II)–indium(III) compounds derived from an acyclic double-compartment Schiff base ligand." Inorganica Chimica Acta 432 (June 2015): 169–75. http://dx.doi.org/10.1016/j.ica.2015.03.041.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Singh, R. V., S. C. Joshi, Shalini Kulshrestha, Pooja Nagpal, and Anil Bansal. "Antiandrogen and Antimicrobial Aspects of Coordination Compounds of Palladium(II), Platinum(II) and Lead(II)." Metal-Based Drugs 8, no. 3 (January 1, 2001): 149–58. http://dx.doi.org/10.1155/mbd.2001.149.

Full text

Abstract:

Synthesis, characterization and antimicrobial activities of an interesting class of biologically potent macrocyclic complexes have been carried out. All the complexes have been evaluated for their antimicrobial effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed. The resulting biologically active [M(MaLn)(R2)]Cl2 and [Pb(MaLn)(R2)X2] (where, M = PdII or PtII and X = Cl or NO3) type of complexes have been synthesized by the reactions of macrocyclic ligands (MaLn) with metal salts and different diamines in 1:1:1 molar ratio in methanol. Initially the complexes were characterized by elemental analyses, molecular weight determinations and conductivity measurements. The mode of bonding was established on the basis of IR, H1 NMR, C13 NMR, Pt195 NMR, Pb207 NMR, XRD and electronic spectral studies. The macrocyclic ligand coordinates through the four azomethine nitrogen atoms which are bridged by benzil moieties. IR spectra suggest that the pyridine nitrogen is not coordinating. The palladium and platinum complexes exhibit tetracoordinated square-planar geometry, whereas a hexacoordinated octahedral geometry is suggested for lead complexes.

APA, Harvard, Vancouver, ISO, and other styles

10

Leung, Wing-Por, Ka-Po Chan, Kwok-Wai Kan, and Thomas C. W. Mak. "Synthesis of Heteroleptic Tin(II) and Lead(II) Compounds from Pyrazyl-Linked Bisphosphoranoimine." Organometallics 27, no. 12 (June 2008): 2767–73. http://dx.doi.org/10.1021/om800104x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Yan, Zhenning, Qian Zhang, Junying Dan, Yipeng Guo, and Liqin Li. "Lead(II) and copper(II) ion-selective electrodes based on two heterocyclic compounds." Journal of Analytical Chemistry 66, no. 10 (September 30, 2011): 974–80. http://dx.doi.org/10.1134/s1061934811100200.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Schwade, Vânia Denise, and Bárbara Tirloni. "One- and two-dimensional PbII compounds resulting from reaction of PbBr2 and Pb(SCN)2 with pyrimidine-2-thione." Acta Crystallographica Section C Structural Chemistry 77, no. 7 (June 25, 2021): 402–10. http://dx.doi.org/10.1107/s2053229621006379.

Full text

Abstract:

Pyrimidine-2-thione (HSpym) reacts with lead(II) thiocyanate and lead(II) bromide in N,N-dimethylformamide (DMF) to form poly[(μ-isothiocyanato-κ2 N:S)(μ4-pyrimidine-2-thiolato-κ6 N 1,S:S:S:S,N 3)lead(II)], [Pb(C4H3N2S)(NCS)] n or [Pb(Spym)(NCS)] n , (I), and the polymeric one-dimensional (1D) compound catena-poly[[μ4-bromido-di-μ-bromido-(μ-pyrimidine-2-thiolato-κ3 N 1,S:S)(μ-pyrimidine-2-thione-κ3 N 1,S:S)dilead(II)] N,N-dimethylformamide monosolvate], {[Pb2Br3(C4H3N2S)(C4H4N2S)]·C3H7NO} n or {[Pb2Br3(Spym)(HSpym)]·DMF} n , (IIa), respectively. Poly[μ4-bromido-di-μ3-bromido-(μ-pyrimidine-2-thiolato-κ3 N 1,S:S)(μ-pyrimidine-2-thione-κ3 N 1,S:S)dilead(II)], [Pb2Br3(C4H3N2S)(C4H4N2S)] n or [Pb2Br3(Spym)(HSpym)] n , (IIb), could be obtained as a mixture with (IIa) when using a lesser amount of solvent. In the crystal structures of the pseudohalide/halide PbII stable compounds, coordination of anionic and neutral HSpym has been observed. Both Spym− (in the thiolate tautomeric form) and NCS− ligands were responsible for the two-dimensional (2D) arrangement in (I). The Br− ligands establish the 1D polymeric arrangement in (IIa). Eight-coordinated metal centres have been observed in both compounds, when considering the Pb...S and Pb...Br interactions. Both compounds were characterized by FT–IR and diffuse reflectance spectroscopies, as well as by powder X-ray diffraction. Compound (IIa) and its desolvated version (IIb) represent the first structurally characterized PbII compounds containing neutral HSpym and anionic Spym− ligands. After a prolonged time in solution, (IIa) is converted to another compound due to complete deprotonation of HSpym. The structural characterization of (I) and (II) suggests HSpym as a good candidate for the removal of PbII ions from solutions containing thiocyanate or bromide ions.

APA, Harvard, Vancouver, ISO, and other styles

13

Mahmoudi, Ghodrat, Ennio Zangrando, Mariusz P. Mitoraj, Atash V. Gurbanov, Fedor I. Zubkov, Maryam Moosavifar, Irina A. Konyaeva, Alexander M. Kirillov, and Damir A. Safin. "Extended lead(ii) architectures engineered via tetrel bonding interactions." New Journal of Chemistry 42, no. 7 (2018): 4959–71. http://dx.doi.org/10.1039/c8nj00525g.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Wong, P. T. S., Y. K. Chau, J. L. Yaromich, and O. Kramar. "Bioaccumulation and Metabolism of Tri- and Dialkyllead Compounds by a Freshwater Alga." Canadian Journal of Fisheries and Aquatic Sciences 44, no. 6 (June 1, 1987): 1257–60. http://dx.doi.org/10.1139/f87-148.

Full text

Abstract:

A freshwater green alga, Ankistrodesmus falcatus, exposed to solutions of trialkyllead, dialkyllead, and inorganic lead (II) compounds (1 mg/L) for 24 h accumulated these compounds with concentration factors of about 100, 2000, and 20 000, respectively. Incubation of this alga with trimethyllead and dimethyllead species over a long period (28 d) revealed the ability of the organism to metabolize these compounds. The metabolic processes for trimethyllead followed a dealkylation sequence with the formation of dimethyllead and lead (II) compounds. The alga not ony accumulated dimethyllead, but also contained significant amounts of trimethyllead and lead (II) compounds. Neither chemical disproportionation reactions nor photodecomposition could account for the quantities produced.

APA, Harvard, Vancouver, ISO, and other styles

15

Kim, Jean Y., Ronald R. Fenton, Brett A. Hunter, and Brendan J. Kennedy. "Powder diffraction studies of synthetic calcium and lead apatites." Australian Journal of Chemistry 53, no. 8 (2000): 679. http://dx.doi.org/10.1071/ch00060.

Full text

Abstract:

The crystal structures of M10(PO4)6X2, where M = Ca or Pb and X = OH¯, F¯, Cl¯ or Br¯, have been determined by Rietveld refinement of powder synchrotron X-ray and neutron diffraction data. All the compounds are hexagonal with space group P 63/m. For the calcium compounds, the lattice parameters are a = 9.4302(5), 9.3475(3), 9.5902(6), 9.6482(6) and c = 6.8911(2), 6.8646(1), 6.7666(2), 6.7788(2) Å, for X = OH¯, F¯, Cl¯, Br¯, respectively. For the lead compounds, the corresponding lattice parameters are a = 9.8612(4), 9.7547(5), 9.9767(4), 10.0618(3) and c = 7.4242(2), 7.2832(2), 7.3255(1), 7.3592(1) Å. In these compounds there are two cation sites, a channel of M(I) atoms and a triangle of M(II) atoms. The anion interacts most strongly with the M(II) atoms with the interaction dictating the position of the anion relative to the M(II) triangle. In Ca10(PO4)6X2, the F¯ ion sits within the triangle planes, while the larger OH¯ and Cl¯ anions are disordered above and below the M(II) triangles. The even larger Br¯ is midway between two triangles at (0, 0, ). Despite the larger size of the isostructural lead compounds, no anions are found in the triangles. The F¯, Cl¯ and Br¯ ions are at (0, 0, ) and the OH¯ ion is disordered at (0, 0, z). This difference in behaviour is possibly related to the lead 6s electrons. In this paper, the experimental results are presented and possible reasons for the observed differences are discussed.

APA, Harvard, Vancouver, ISO, and other styles

16

Echeverría, Gustavo A., Oscar E. Piro, Beatriz S. Parajón-Costa, and Enrique J. Baran. "Structural and IR-spectroscopic characterization of cadmium and lead(II) acesulfamates." Zeitschrift für Naturforschung B 72, no. 10 (September 26, 2017): 739–45. http://dx.doi.org/10.1515/znb-2017-0116.

Full text

Abstract:

AbstractCadmium and lead(II) acesulfamate, Cd(C4H4NO4S)2·2H2O and Pb(C4H4NO4S)2, were prepared by the reaction of acesulfamic acid and the respective metal carbonates in aqueous solution, and characterized by elemental analysis. Their crystal structures were determined by single crystal X-ray diffraction methods. The Cd(II) compound crystallizes in the monoclinic space groupP21/cwithZ=4 and the corresponding Pb(II) salt in the triclinic space groupP1̅ withZ=2. In both salts, acesulfamate acts both as a bi-dentate ligand through its nitrogen and carbonyl oxygen atoms and also as a mono-dentate ligand through this same oxygen atom, giving rise to polymeric structures; in the Pb(II) salt the ligand also binds the cation through its sulfoxido oxygen atoms. The FTIR spectra of the compounds were recorded and are briefly discussed. Some comparisons with other related acesulfamate and saccharinate complexes are made.

APA, Harvard, Vancouver, ISO, and other styles

17

Gribchenkova, N. A., K. G. Smorchkov, A. S. Smirnov, and A. S. Alikhanyan. "Thermodynamics of Compounds Based on Lead(II) and Zinc(II) Oxides in Gas Phase." Russian Journal of Inorganic Chemistry 66, no. 3 (March 2021): 385–90. http://dx.doi.org/10.1134/s0036023621030098.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Wagner, Christoph, and Kurt Merzweiler. "Novel Dinuclear Tin(II) and Lead(II) Compounds with 2-Pyridyl Functionalized Silylamido Ligands." Zeitschrift für anorganische und allgemeine Chemie 643, no. 14 (July 18, 2017): 938–44. http://dx.doi.org/10.1002/zaac.201700167.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Xu, Zhi-Yuan, Tong Feng, Qing Liu, Hui-Ting Li, Wei Wei, Rong-Chuan Shi, Yi-Ming Cao, and Shang-Zhong Liu. "Design, Synthesis, Fungicidal and Insecticidal Activities of Novel Diamide Compounds Combining Pyrazolyl and Polyfluoro-Substituted Phenyl into Alanine or 2-Aminobutyric Acid Skeletons." Molecules 28, no. 2 (January 5, 2023): 561. http://dx.doi.org/10.3390/molecules28020561.

Full text

Abstract:

Thirty novel diamide compounds combining pyrazolyl and polyfluoro-substituted phenyl groups into alanine or 2-aminobutyric acid skeletons were designed and synthesized with pyflubumide as the lead compound to develop potent and environmentally friendly pesticides. The preliminary bioassay results indicated that the new compounds containing the para-hexa/heptafluoroisopropylphenyl moiety exhibit fungicidal, insecticidal, and acaricidal activities. This is the first time that the para-hexa/heptafluoroisopropylphenyl group is a key fragment of the fungicidal activity of new N-phenyl amide compounds. Most of the target compounds exhibited moderate to good insecticidal activity against Aphis craccivora at a concentration of 400 μg/mL, and some showed moderate activity at a concentration of 200 μg/mL; in particular, compounds I-4, II-a-10, and III-26 displayed higher than 78% lethal rates at 200 μg/mL. Compound II-a-14 exhibited a 61.1% inhibition at 200 μg/mL for Tetranychus cinnabarinus. In addition, some of the target compounds exhibited good insecticidal activities against Plutella xylostella at a concentration of 200 μg/mL; the mortalities of compounds I-1, and II-a-15 were 76.7% and 70.0%, respectively. Preliminary analysis of the structure–activity relationship (SAR) indicated that the insecticidal and acaricidal activities varied significantly depending on the type of substituent and substitution pattern. The fungicidal activity results showed that compounds I-1, II-a-10, II-a-17, and III-26 exhibited good antifungal effects. Enzymatic activity experiments and in vivo efficacy of compound II-a-10 were conducted and discussed.

APA, Harvard, Vancouver, ISO, and other styles

20

Oliveira Araujo, Vinicius, Gleison Antonio Casagrande, Bárbara Tirloni, and Vânia Denise Schwade. "Lead(II) compounds with neutral coordination of semicarbazones: Synthesis and characterization." Inorganica Chimica Acta 533 (April 2022): 120785. http://dx.doi.org/10.1016/j.ica.2021.120785.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Du, Zi-Yi, Hai-Bing Xu, Xiu-Ling Li, and Jiang-Gao Mao. "A New Approach to Novel Cluster Compounds of Lead(II) Phosphonates." European Journal of Inorganic Chemistry 2007, no. 28 (October 2007): 4520–29. http://dx.doi.org/10.1002/ejic.200700463.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

CARVALHO FILHO, Marco Aurélio da Silva, and Massao IONASHIRO. "Thermal behaviour study of solid state compounds of manganese (II), zinc (II) and lead (II) with cinnamic acid." Eclética Química 23 (1998): 09–16. http://dx.doi.org/10.1590/s0100-46701998000100001.

Full text

Abstract:

Compounds of cinnamic acid with manganese, zinc and lead have been prepared in aqueous solution. Thermogravimetry, derivative thermogravimetry (TG, DTG), differential scanning calorimetry (DSC), X-ray diffraction and complexometry have been used in the characterization as well as in the study of the thermal stability and interpretation concerning the thermal decomposition.

APA, Harvard, Vancouver, ISO, and other styles

23

Wang, Yu-Ling, Yun-Liang Jiang, Qing-Yan Liu, Jia-Jia Wei, and Li-Qin Li. "Silver(I) and Lead(II) Halide Compounds with 4-Methyl-1,2,4-triazole-3-thiol." Australian Journal of Chemistry 65, no. 1 (2012): 50. http://dx.doi.org/10.1071/ch11261.

Full text

Abstract:

Four novel silver(i) and lead(ii) halide compounds with the 4-methyl-1,2,4-triazole-3-thiol (Hmptrz) ligand, namely [Ag2(mptrz)(μ3-X)]n (X = I (1) and Br (2)) and [Pb4(μ4-O)(mptrz)4(μ2-X)2] (X = I (3) and Cl (4)), have been synthesized and characterized. The structures exhibit different dimensionality depending on the nature of the metal ions. Compounds 1 and 2 are isomorphous and have 2D layered structures based on inorganic [Ag2X2]n infinite chains (X = I and Br), in which the mptrz– ligand displays a novel pentadentate bridging coordination mode. Compounds 3 and 4 have similar structures and are composed of a discrete tetranuclear lead(ii) cluster featuring an oxygen-centred Pb4(µ4-O) tetrahedron. Compounds 1 and 2 display solid-state photoluminescent emission with the maximum at 589 and 420 nm respectively. Compounds 3 and 4 show solid-state photoluminescent emission with the maximum at 710 and 540 nm respectively. Additionally, compounds 1–4 were characterized by IR, elemental analysis, powder X-ray diffraction and thermogravimetric analysis.

APA, Harvard, Vancouver, ISO, and other styles

24

Luo, Lianxiang, Tongyu Zheng, Qu Wang, Yingling Liao, Xiaoqi Zheng, Ai Zhong, Zunnan Huang, and Hui Luo. "Virtual Screening Based on Machine Learning Explores Mangrove Natural Products as KRASG12C Inhibitors." Pharmaceuticals 15, no. 5 (May 8, 2022): 584. http://dx.doi.org/10.3390/ph15050584.

Full text

Abstract:

Mangrove secondary metabolites have many unique biological activities. We identified lead compounds among them that might target KRASG12C. KRAS is considered to be closely related to various cancers. A variety of novel small molecules that directly target KRAS are being developed, including covalent allosteric inhibitors for KRASG12C mutant, protein–protein interaction inhibitors that bind in the switch I/II pocket or the A59 site, and GTP-competitive inhibitors targeting the nucleotide-binding site. To identify a candidate pool of mangrove secondary metabolic natural products, we tested various machine learning algorithms and selected random forest as a model for predicting the targeting activity of compounds. Lead compounds were then subjected to virtual screening and covalent docking, integrated absorption, distribution, metabolism and excretion (ADME) testing, and structure-based pharmacophore model validation to select the most suitable compounds. Finally, we performed molecular dynamics simulations to verify the binding mode of the lead compound to KRASG12C. The lazypredict function package was initially used, and the Accuracy score and F1 score of the random forest algorithm exceeded 60%, which can be considered to carry a strong ability to distinguish the data. Four marine natural products were obtained through machine learning identification and covalent docking screening. Compound 44 and compound 14 were selected for further validation after ADME and toxicity studies, and pharmacophore analysis indicated that they had a favorable pharmacodynamic profile. Comparison with the positive control showed that they stabilized switch I and switch II, and like MRTX849, retained a novel binding mechanism at the molecular level. Molecular dynamics analysis showed that they maintained a stable conformation with the target protein, so compound 44 and compound 14 may be effective inhibitors of the G12C mutant. These findings reveal that the mangrove-derived secondary metabolite compound 44 and compound 14 might be potential therapeutic agents for KRASG12C.

APA, Harvard, Vancouver, ISO, and other styles

25

Arkhipov, A. Yu, A. A. Abramov, N. A. Ivanova, B. Z. Iofa, O. P. Pronina, Yu A. Sapozhnikov, and A. V. Anisimov. "Extraction of strontium(II), silver(I), and lead(II) with some oxathia- and thiacrown compounds." Chemistry of Heterocyclic Compounds 32, no. 11-12 (1997): 1419–22. http://dx.doi.org/10.1007/bf01169970.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Bareš, Josef, Philippe Richard, Philippe Meunier, Nadine Pirio, Zdeňka Padělková, Zdeněk Černošek, Ivana Císařová, and Aleš Růžička. "Reactions of C,N-chelated Tin(II) and Lead(II) Compounds with Zirconocene Dichloride Derivatives." Organometallics 28, no. 10 (May 25, 2009): 3105–8. http://dx.doi.org/10.1021/om801120a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Afanasenko, E. V., I. I. Seifullina, O. E. Martsinko, L. O. Konup, and M. M. Kyryk. "Double Coordination Compounds of Fe(II)/Co(II)/Ni(II)/Cu(II) 1,10-Phenanthroline/2,2ʹ-Bipyridine Cations with Tartratogermanate(IV) Anions as Novel Nonresistant Antimicrobial Agents." Mikrobiolohichnyi Zhurnal 84, no. 2 (November 28, 2022): 3–11. http://dx.doi.org/10.15407/microbiolj84.02.003.

Full text

Abstract:

Objective. To study the antimicrobial activity of double coordination compounds with 1,10-phenanthroline/2,2ʹ-bipyridine complexes of Fe(II)/Co(II)/Ni(II)/Cu(II) as cations and diff erent tartratogermanate(IV) anions, reveal the main factors of their effi ciency and establish relations between their composition, structure features, and biological properties. Methods. The developed synthesis method allowed us to obtain three diff erent tartratogermanate anions, which exist together in the solution and can be selectively recognized by the certain type of 1,10-phenanthroline/2,2ʹ-bipyridine cation. Th e antimicrobial activity of the compound was investigated by a rapid twofold dilution method in a standard liquid nutrient medium (Hottinger digestion) to determine the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). Results. Th e complex nature of studied compounds, synergism of their biologically active structural units, and the presence of diff erent types of intermolecular bonds result in the high antimicrobial activity against a wide range of microorganisms such as gram-positive Planococcus citreus, Microcoсcus luteus, Bacillus cereus, Staphylococcus aureus, Streptococcus lactis, and, in a less degree, gram-negative Escherichia coli and Agrobacterium tumefaciens. Compounds (1)—(8) show a high antimicrobial activity because all of them belong to the type of double coordination compounds and contain similar structural units. Nevertheless, complexes (1) (23.44 μg/mL), (3) (46.9 μg/mL), (4) (23.44 μg/mL), and (8) (46.9 μg/mL) turned out to be the most eff ective, while (6) (>500 μg/mL) and (7) (>500 μg/mL) are less productive. Complexes that have anions [Ge2(OH)(H2Tart)(μ-Tart)2]3- (1), (8) and [Ge2(OH)(HTart)(μ-Tart)2]4- (4) with free hydroxyl and carboxyl groups of the terminal tartaric acid are able to interact with metals in the enzymes of microorganisms and appear to be better antimicrobial drugs because they show lower inhibitory and bactericidal concentrations. Conclusions. Structural features such as the cation-anionic type of compounds, variability of intermolecular interactions, joint of diff erent biologically active units and free chelating groups in tartaric ligands lead to the combination of different action mechanisms and exclude the possibility of strain resistance.

APA, Harvard, Vancouver, ISO, and other styles

28

Schwade, Vânia Denise, Tiago Bessega, Ernesto Schulz Lang, and Ulrich Abram. "Pb⋯N interactions and π-stacking in lead(II) bis(hydrazone) compounds." Polyhedron 112 (July 2016): 96–103. http://dx.doi.org/10.1016/j.poly.2016.04.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Breza, Martin, Lukáš Bučinský, Stanislava Šoralová, and Stanislav Biskupič. "On the origin of the hemidirected geometry of tetracoordinated lead(II) compounds." Chemical Physics 368, no. 1-2 (February 2010): 14–19. http://dx.doi.org/10.1016/j.chemphys.2009.12.003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Hu, Mao-Lin, Ali Morsali, and Leila Aboutorabi. "Lead(II) carboxylate supramolecular compounds: Coordination modes, structures and nano-structures aspects." Coordination Chemistry Reviews 255, no. 23-24 (December 2011): 2821–59. http://dx.doi.org/10.1016/j.ccr.2011.05.019.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Khotimchenko, Maxim, Valeri Kovalev, and Yuri Khotimchenko. "Equilibrium studies of sorption of lead(II) ions by different pectin compounds." Journal of Hazardous Materials 149, no. 3 (November 2007): 693–99. http://dx.doi.org/10.1016/j.jhazmat.2007.04.030.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Juang, Ruey-Shin, and Shwu-Hwa Lee. "Extraction equilibria of lead(II) from nitrate solutions with acidic organophosphorus compounds." Journal of Chemical Technology AND Biotechnology 60, no. 1 (May 1994): 61–66. http://dx.doi.org/10.1002/jctb.280600110.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Shanak, Siba, Najlaa Bassalat, Ahmad Barghash, Sleman Kadan, Mahmoud Ardah, and Hilal Zaid. "Drug Discovery of Plausible Lead Natural Compounds That Target the Insulin Signaling Pathway: Bioinformatics Approaches." Evidence-Based Complementary and Alternative Medicine 2022 (March 20, 2022): 1–42. http://dx.doi.org/10.1155/2022/2832889.

Full text

Abstract:

The growing smooth talk in the field of natural compounds is due to the ancient and current interest in herbal medicine and their potentially positive effects on health. Dozens of antidiabetic natural compounds were reported and tested in vivo, in silico, and in vitro. The role of these natural compounds, their actions on the insulin signaling pathway, and the stimulation of the glucose transporter-4 (GLUT4) insulin-responsive translocation to the plasma membrane (PM) are all crucial in the treatment of diabetes and insulin resistance. In this review, we collected and summarized a group of available in vivo and in vitro studies which targeted isolated phytochemicals with possible antidiabetic activity. Moreover, the in silico docking of natural compounds with some of the insulin signaling cascade key proteins is also summarized based on the current literature. In this review, hundreds of recent studies on pure natural compounds that alleviate type II diabetes mellitus (type II DM) were revised. We focused on natural compounds that could potentially regulate blood glucose and stimulate GLUT4 translocation through the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway. On attempt to point out potential new natural antidiabetic compounds, this review also focuses on natural ingredients that were shown to interact with proteins in the insulin signaling pathway in silico, regardless of their in vitro/in vivo antidiabetic activity. We invite interested researchers to test these compounds as potential novel type II DM drugs and explore their therapeutic mechanisms.

APA, Harvard, Vancouver, ISO, and other styles

34

Chinchilli, Krishna Kartheek, Andrea Angeli, Pavitra S. Thacker, Laxman Naik Korra, Rashmita Biswas, Mohammed Arifuddin, and Claudiu T. Supuran. "Design, Synthesis, and Biological Evaluation of 1,2,3-Triazole-linked triazino[5,6-b]indole-benzene sulfonamide Conjugates as Potent Carbonic Anhydrase I, II, IX, and XIII Inhibitors." Metabolites 10, no. 5 (May 15, 2020): 200. http://dx.doi.org/10.3390/metabo10050200.

Full text

Abstract:

A series of 1,2,3-triazole-linked triazino[5,6-b]indole-benzene sulfonamide hybrids (6a–6o) was synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activity against the human (h) isoforms hCA I, II, XIII (cytosolic isoforms), and hCA IX (transmembrane tumor-associated isoform). The results revealed that the compounds 6a–6o exhibited Ki values in the low to medium nanomolar range against hCA II and hCA IX (Kis ranging from 7.7 nM to 41.3 nM) and higher Ki values against hCA I and hCA XIII. Compound 6i showed potent inhibition of hCA II (Ki = 7.7nM), being more effective compared to the standard inhibitor acetazolamide (AAZ) (Ki = 12.1 nM). Compounds 6b and 6d showed moderate activity against hCA XIII (Ki = 69.8 and 65.8 nM). Hence, compound 6i could be consider as potential lead candidate for the design of potent and selective hCA II inhibitors.

APA, Harvard, Vancouver, ISO, and other styles

35

Dong, ZhiLi, and T. J. White. "Calcium–lead fluoro-vanadinite apatites. II. Equilibrium structures." Acta Crystallographica Section B Structural Science 60, no. 2 (March 18, 2004): 146–54. http://dx.doi.org/10.1107/s0108768104001843.

Full text

Abstract:

The synthetic vanadinites (Pb x Ca10−x )(VO4)6(F1−2y O y □ y )2, 0.57 < x < 9 and 0.10 < y < 0.47, adopt the P63/m apatite structure with 9.7835 (3) ≤ a ≤ 10.0531 (1) Å and 7.0318 (2) ≤ c ≤ 7.3033 (1) Å. The calcium endmember is monoclinic, space group P21/m, with a = 9.7370 (3), b = 9.7358 (4), c = 7.00572 (9) Å, γ = 120.002 (5)°. For mixed metal compounds (x ≠ 0) the partitioning of calcium and lead over the A I(4f) and A II(6h) positions is nonstoichiometric, with lead preferentially favouring the larger A II site at a partitioning coefficient k Pb(A I/A II) ≃ 0.33 for all x < 7. A miscibility gap exists for 2 < x < 3. Trends in crystallographic parameters can be correlated through consideration of the A IO6 metaprism twist angle (φ) that can be used to derive ideal cell parameters from triangular anion networks.

APA, Harvard, Vancouver, ISO, and other styles

36

Sharma, Anupama, Shivendra Singh, and Harlal Singh. "Lead(II) Schiff Base Complexes: Design, Synthesis, Theoretical, Antibacterial and Docking Studies." Asian Journal of Chemistry 34, no. 4 (2022): 945–52. http://dx.doi.org/10.14233/ajchem.2022.23634.

Full text

Abstract:

This study presented the bioactive lead(II) compounds of oxazine and thiazine Schiff-bases using NMR (1H, 13C), FT-infrared spectroscopy, UV-visible, molar conductance, elemental analysis and molecular weight. The molecular parameters e.g. bond length, bond angle, HOMO/LUMO energy gap and softness/hardness was calculated by DFT-B3LYP/Lanl2dz basis set. According to the spectral data, the Schiff-base coordinated to the lead atom in bidentate mode. A theoretical DFT computational investigation was conducted to supplement the experimental data. The antibacterial activity of lead complexes against E. coli (–) and S. aureus (+) bacteria was determined by disc-diffusion method. Lead complexes of thiazine derivatives are more active than oxazine derivatives. In order to better understand the molecular interaction and binding mode of the drugs, a molecular docking study has been carried out on the protein 3q8u (NDK) from S. aureus. A docking investigation with the NDK protein (S. aureus) revealed that compound 1h has the highest binding affinity (-8.18 Kcal/mol) among the eight ligands (1a-h).

APA, Harvard, Vancouver, ISO, and other styles

37

Chen, Kuen-Bao, Hsin-Yi Chen, Kuan-Chung Chen, and Calvin Yu-Chian Chen. "Treatment of Cardiovascular Disease by Traditional Chinese Medicine against Pregnane X Receptor." BioMed Research International 2014 (2014): 1–17. http://dx.doi.org/10.1155/2014/950191.

Full text

Abstract:

Recently, cardiovascular disease, also known as loop circulatory system diseases or disorders, is one of the serious diseases including heart disease, stroke, atherosclerosis, myocardial infarction, hypertension, hypotension, and thrombosis. Human pregnane X receptor, PXR, plays a crucial role in exogenous and endobiotic metabolism for rabbit, rat, mouse, and human. The PXR activation can protect the blood vessels from damage of hazardous substances. In this study we aim to investigate the potent lead compounds as PXR receptor agonist against cardiovascular disease. To improve drug development of TCM compounds, we aim to investigate the potent lead compounds as PXR agonists from the TCM compounds in TCM Database@Taiwan. The top three TCM compounds, bis(4-hydroxybenzyl) ether mono-β-D-glucopyranoside (BEMG), ixerisoside, and tangshenoside II, have displayed higher potent binding affinities than the positive control, PNU-142721, in the docking simulation. After MD simulations, which can optimize the result of docking simulation and validate the stability of H-bonds between each ligand and PXR protein under dynamic conditions, top TCM compounds, BEMG and tangshenoside II, maintain most of interactions with PXR protein, which keep the ligand binding stable in the binding domain. Hence, we propose BEMG and tangshenoside II as potential lead compounds for further study in drug development process with the PXR protein.

APA, Harvard, Vancouver, ISO, and other styles

38

Engelhardt, LM, DL Kepert, JM Patrick, and AH White. "Lewis-Base Adducts of Lead(II) Compounds. II. Nine-Coordinate Capped Square-Antiprism Stereochemistry, [M(bidentate)4(unidentate)], in Tetrakis(1,10-phenanthroline)(perchlorato-O)lead(II) Perchlorate." Australian Journal of Chemistry 42, no. 2 (1989): 329. http://dx.doi.org/10.1071/ch9890329.

Full text

Abstract:

Improved precision, consequent upon redetermination of the structure of the title compound [Pb( phen )4(OCIO3)] (CIO4) [5184 'observed', 1 > 2 σ(I), diffractometer reflections; R 0.05 11, enables improved characterization of the nine-coordinate lead(II) environment in terms of a capped square antiprism.

APA, Harvard, Vancouver, ISO, and other styles

39

Baidina, I. A., V. V. Krisyuk, and P. A. Stabnikov. "Structure and properties of heterocomplex compounds based on lead(II) hexafluoroacetylacetonate and copper(II) β-diketonates." Journal of Structural Chemistry 47, no. 6 (November 2006): 1111–16. http://dx.doi.org/10.1007/s10947-006-0433-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Engelhardt, LM, JM Patrick, CR Whitaker, and AH White. "Lewis Base Adducts of Lead(II) Compounds. I. Polymer Isomerism in Some 1-2 Adducts of Lead(II) Halides With Pyridine Bases." Australian Journal of Chemistry 40, no. 12 (1987): 2107. http://dx.doi.org/10.1071/ch9872107.

Full text

Abstract:

Recrystallization of lead(II) halides, PbX2 (X = C1, Br, I), from n- methylpyridine, n = 3, 4, yields crystalline 1 : 2 adducts; these have all been shown by single-crystal X-ray structure determination to contain the lead in an essentially octahedral six-coordinate environment, two of the coordination sites being occupied by monodentate pyridine base moieties and four by bridging halogen, yielding infinite polymeric arrays. For X = Cl, Br, n = 3, the nitrogen atoms lie cis in the coordination sphere; for the other complexes, they are trans. In the two cis complexes, distortion from ideal orthogonal geometry is more substantial than in the trans, possibly indicative of the presence of a sterically active 'lone pair'.

APA, Harvard, Vancouver, ISO, and other styles

41

Harrowfield, JM, H. Miyamae, TM Shand, BW Skelton, AA Soudi, and AH White. "Lewis-Base Adducts of Lead(II) Compounds. VIII. Synthetic and Structural Studies of Some Adducts of Linear Polyamines With Lead(II) Bromide." Australian Journal of Chemistry 49, no. 10 (1996): 1043. http://dx.doi.org/10.1071/ch9961043.

Full text

Abstract:

Syntheses and room-temperature single-crystal X-ray structure determinations are recorded for adducts of lead(II) bromide with some linear polyamines. Adducts with ethane-1,2-diamine ('en') and propane- 1,2-diamine (' pn ') are of 2:1 and 1:1 stoichiometry respectively. [(en)2PbBr2](∞|∞) is monoclinic, C2/c, a 13,076(4), b 7.586(2),c 13.248(4) Ǻ, β 117.88(2)°, Z = 4 f.u .; R was 0.029 for No = 1832 'observed' (I > 3σ(I)) reflections (a redetermination ). [( pn )PbBr2](∞|∞) is orthorhombic, Pbca , a 23.457(3), b 9.567(2), c 7.714(3) Ǻ, Z = 8; R 0.051 for No 1297. [(en)2PbBr2](∞|∞) is a single stranded linear polymer parallel to c; the lead atom, lying on a crystallographic twofold axis, is six-coordinate PbN4Br2, with the bromine atoms cis in the coordination sphere and lying opposed to a bidentate en ligand. The trans sites are linked into a chain by bridging en ligands . [( pn )PbBr2](∞|∞) is a more complex two-dimensional polymer; the pn is bidentate , but the lead atoms are now eight coordinate with doubly and quadruply bridging bromines linking them into the polymeric sheet. The adduct with '323tet' (4,7-diazadecane 1,10-diamine) is of a novel (323tet)2(PbBr2)3 stoichiometry , best represented (simplistically) as {[ Pb (323tet)]2[PbBr6]}(∞|∞); crystals are triclinic, Pī , a 11.892(4), b 9.306(3), c 9.016(6) Ǻ, α 60.74(4), β 86.04(4), γ 74.43(3)°, Z = 1 f.u ., with R 0.061 for No 2071. About one lead atom type, the ligand is quadridentate , lying on one face of the coordination sphere; the region opposite is occupied by four triply bridging bromine atoms from the [PbBr6] anionic units (which contain quasi-octahedral, centrosymmetric lead. with a pair of trans-bromine atoms terminal and the others bridging) linking the array into a two dimensional polymer.

APA, Harvard, Vancouver, ISO, and other styles

42

Harrowfield, JM, H. Miyamae, BW Skelton, AA Soudi, and AH White. "Lewis-Base Adducts of Lead(II) Compounds. XX. Synthesis and Structure of the 1:1 Adduct of Pyridine With Lead(II) Thiocyanate." Australian Journal of Chemistry 49, no. 10 (1996): 1165. http://dx.doi.org/10.1071/ch9961165.

Full text

Abstract:

The synthesis and room-temperature single-crystal X-ray structure determination are recorded for a 1:1 adduct of lead(II) thiocyanate with pyridine (' py '). [( py ) Pb (SCN)2](∞|∞) is triclinic, Pī , a 10.544(1), b 7.3729(7), c 6.705(2) Ǻ, α 103.91(2), β 95.99(2), γ 100.51(1)°, Z = 2 f.u .; R was 0.041 for 3226 'observed' (I > 3σ(I)) reflections. The structure is a two-dimensional polymer in the be plane with eight-coordinate ( py -N)PbN3S4 linked by the familiar four- membered Pb2S2 and eight-membered Pb2(NCS)2 motifs by way of bridging thiocyanate groups; one of the latter, unusually, has a bifurcating bridging nitrogen atom leading to the introduction of Pb2N2 motifs. The structure of the parent lead(II) thiocyanate is also discussed.

APA, Harvard, Vancouver, ISO, and other styles

43

Wrackmeyer, Bernd, Klaus Horchler, and Hong Zhou. "Silylmethyl and silylamino groups as ligands in tin(II), tin(IV), lead(II) and lead(IV) compounds—a multinuclear magnetic resonance study." Spectrochimica Acta Part A: Molecular Spectroscopy 46, no. 5 (January 1990): 809–16. http://dx.doi.org/10.1016/0584-8539(90)80039-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

da Costa, Cristiane França, Marcus Vinicius Nora de Souza, Maria Cristina da Silva Lourenço, Elaine Soares Coimbra, Guilherme da Silva Lourenço Carvalho, James Wardell, Stephane Lima Calixto, and Juliana da Trindade Granato. "Synthesis and SAR Study of Simple Aryl Oximes and Nitrofuranyl Derivatives with Potent Activity Against Mycobacterium tuberculosis." Letters in Drug Design & Discovery 17, no. 1 (December 31, 2019): 12–20. http://dx.doi.org/10.2174/1570180816666181227115738.

Full text

Abstract:

Background: Oximes and nitrofuranyl derivatives are particularly important compounds in medicinal chemistry. Thus, many researchers have been reported to possess antibacterial, antiparasitic, insecticidal and fungicidal activities. Methods: In this work, we report the synthesis and the biological activity against Mycobacterium tuberculosis H37RV of a series of fifty aryl oximes, ArCH=N-OH, I, and eight nitrofuranyl compounds, 2-nitrofuranyl-X, II. Results: Among the oximes, I: Ar = 2-OH-4-OH, 42, and I: Ar = 5-nitrofuranyl, 46, possessed the best activity at 3.74 and 32.0 µM, respectively. Also, 46, the nitrofuran compounds, II; X = MeO, 55, and II: X = NHCH2Ph, 58, (14.6 and 12.6 µM, respectively), exhibited excellent biological activities and were non-cytotoxic. Conclusion: The compound 55 showed a selectivity index of 9.85. Further antibacterial tests were performed with compound 55 which was inactive against Enterococcus faecalis, Klebisiella pneumonae, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhymurium and Shigella flexneri. This study adds important information to the rational design of new lead anti-TB drugs. Structure-activity Relationship (SAR) is reported.

APA, Harvard, Vancouver, ISO, and other styles

45

Pershin, P., V. Batuhtin, O. Tkacheva, P. Arkhipov, and Yu Zaikov. "EQUILIBRIUM POTENTIALS OF LEAD OXIDE (II) IN AN EQUIMOLAR MIXTURE OF KCl-PbCl2." PROBLEMS OF ATOMIC SCIENCE AND TECHNOLOGY. SERIES: NUCLEAR AND REACTOR CONSTANTS 2019, no. 1 (March 26, 2019): 75–86. http://dx.doi.org/10.55176/2414-1038-2019-1-75-86.

Full text

Abstract:

The electromotive forces (EMF) of the electrochemical system (GC)Pb|(1-N)·KCl-PbCl2+N·PbO|ZrO2(Y2O3)|O2(Pt) in the concentration range of PbO 0.16-7.32 % mol. were measured at temperatures 776, 821 and 874 K. From the experimental values of EMF activities, coefficients of the activity and basic thermodynamic functions of lead oxide for dilute solutions were calculated. It is shown that PbO activities in the KCl-PbCl2 melt have moderate negative deviations from Raoul's law for ideal solutions. The activity coefficients of PbO at each temperature within the calculation errors are constant, that is, the diluted solutions of PbO in KCl-PbCl2 obey Henry's law. In the studied area of dilute solutions of PbO solvent activity coefficients are constant within the error, and their value is close to 1, as a consequence of the solvent activity within the calculation error will be equal to its molar fraction. This confirms the rule of Kubashevskii-Alcock about the obedience behavior of the solvent KCl-PbCl2 to Raoult's law for ideal solutions. Partial thermodynamic functions of the solvent - melt KCl-PbCl2 and integral thermodynamic functions of the KCl-PbCl2-PbO system are calculated using the standard equations. The interaction of lead oxide with chloride melts is caused by the formation of oxychloride compounds. According to the literature, there is a compound {[Pb2OCl]++Cl-} in the ion melt. The results of x-ray phase analysis show the presence of Pb2OCl2 compound in the frozen electrolyte melt. Using the device LECO ONH836 the concentration of oxygen in the metal lead was determined. It is shown that the oxygen concentration was 0.031 wt. % after the long-term exposure, which also exceeds the values in the Pb-O diagram almost twice.

APA, Harvard, Vancouver, ISO, and other styles

46

Zhu, Qiannan, Min Lin, Wanying Zhuo, and Yunzhi Li. "Chemical Constituents from the Wild Atractylodes macrocephala Koidz and Acetylcholinesterase Inhibitory Activity Evaluation as Well as Molecular Docking Study." Molecules 26, no. 23 (December 1, 2021): 7299. http://dx.doi.org/10.3390/molecules26237299.

Full text

Abstract:

Screening the lead compounds which could interact both with PAS and CAS of acetylcholinesterase (AChE) is an important trend in finding innovative drugs for Alzheimer’s disease (AD). In this paper, four sesquiterpenes, i.e., atractylenolide III (1), atractylenolide IV (2), 3-acetyl-atractylon (3) and β-eudesmol (4), were obtained from the wild Atractylode macrocephala grown in Qimen for the first time. Their structures were elucidated mainly by NMR spectroscopy. To screen the potential dual site inhibitors of AChE, the compounds 1, 2, 3, as well as a novel and rare bisesquiterpenoid lactone, biatractylenolide II (5), which was also obtained from the tilted plant in our previous investigation, were evaluated their AChE inhibitory activities by using Ellman’s colorimetric method. The results showed that biatractylenolide II displayed moderate inhibitory activity (IC50 = 19.61 ± 1.11 μg/mL) on AChE. A further molecular docking study revealed that biatractylenolide II can interact with both the peripheral anionic site (PAS) and the catalytic active site (CAS) of AChE. These data suggest that biatractylenolide II can be considered a new lead compound to research and develop more potential dual site inhibitors of AChE.

APA, Harvard, Vancouver, ISO, and other styles

47

Chu, Naying, Yitong Wang, Hao Jia, Jie Han, Xiaoyi Wang, and Zhuang Hou. "Design, Synthesis and Biological Evaluation of New Carbohydrate-Based Coumarin Derivatives as Selective Carbonic Anhydrase IX Inhibitors via “Click” Reaction." Molecules 27, no. 17 (August 25, 2022): 5464. http://dx.doi.org/10.3390/molecules27175464.

Full text

Abstract:

In this work, we designed a series of new carbohydrate-based coumarin carbonic anhydrase IX inhibitors by using 1,2,3-triazoles as linker. Next, these designed compounds were synthesized by the optimized one-pot click chemistry reaction condition. Subsequently, these target compounds were assayed for the inhibition of three carbonic anhydrase isoforms (CA I, CA II and CA IX). Intriguingly, all the compounds showed better CA IX inhibitory activity than initial coumarin fragments. Among them, compound 10a (IC50: 11 nM) possessed the most potent CA IX inhibitory activity, which was more potent than the reference drug acetazolamide (IC50: 30 nM). Notably, compound 10a showed 3018-fold, 1955-fold selectivity relative to CA I and CA II, respectively. Meanwhile, representative compounds could reduce tumor cell viability and the extracellular acidification in HT-29 and MDA-MB-231 cancer cell lines. Even more interestingly, our target compounds had no apparent cytotoxicity toward MCF-10A cell line. In addition, the in vitro stability assays also indicated our developed compounds possessed good liver microsomal metabolic stabilities and plasma stability. Furthermore, representative compounds revealed relatively low hERG cardiac toxicity and acute toxicity. Furthermore, docking studies were carried out to understand the interactions of our target compounds with the protein target CA IX. Collectively, our results suggest that compound 10a, as a selective CA IX inhibitor, could be an important lead compound for further optimization and development as an anticancer agent.

APA, Harvard, Vancouver, ISO, and other styles

48

Stroyuk, Oleksandr. "Lead-free hybrid perovskites for photovoltaics." Beilstein Journal of Nanotechnology 9 (August 21, 2018): 2209–35. http://dx.doi.org/10.3762/bjnano.9.207.

Full text

Abstract:

This review covers the state-of-the-art in organo–inorganic lead-free hybrid perovskites (HPs) and applications of these exciting materials as light harvesters in photovoltaic systems. Special emphasis is placed on the influence of the spatial organization of HP materials both on the micro- and nanometer scale on the performance and stability of perovskite-based solar light converters. This review also discusses HP materials produced by isovalent lead(II) substitution with Sn2+ and other metal(II) ions, perovskite materials formed on the basis of M3+ cations (Sb3+, Bi3+) as well as on combinations of M+/M3+ ions aliovalent to 2Pb2+ (Ag+/Bi3+, Ag+/Sb3+, etc.). The survey is concluded with an outlook highlighting the most promising strategies for future progress of photovoltaic systems based on lead-free perovskite compounds.

APA, Harvard, Vancouver, ISO, and other styles

49

Yang, Gao Wen, Fei Fei Zhang, Qi Wu, Meng Jie Cao, Yu Bai, Qiao Yun Li, Bo Wei, and Jian Hua Zou. "Substituted group directed assembly of energetic lead(ii) compounds based on structure-relevant ligands." RSC Advances 5, no. 103 (2015): 84439–45. http://dx.doi.org/10.1039/c5ra17301a.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Galiński, Błażej, Elżbieta Luboch, Jarosław Chojnacki, and Ewa Wagner-Wysiecka. "Novel Diazocrowns with Pyrrole Residue as Lead(II)Colorimetric Probes." Materials 14, no. 23 (November 26, 2021): 7239. http://dx.doi.org/10.3390/ma14237239.

Full text

Abstract:

Novel 18- and 23-membered diazomacrocycles were obtained with satisfactory yields by diazocoupling of aromatic diamines with pyrrole in reactions carried under high dilution conditions. X-ray structure of macrocycle bearing five carbon atoms linkage was determined and described. Compounds were characterized as chromogenic heavy metal ions receptors. Selective color and spectral response for lead(II) was found in acetonitrile and its mixture with water. Complexation properties of newly obtained macrocycles with a hydrocarbon chain were compared with the properties of their oligoether analogs. The influence of the introduction of hydrocarbon residue as a part of macrocycle on the lead(II) binding was discussed. Selective and sensitive colorimetric probe for lead(II) in aqueous acetonitrile with detection limit 56.1 μg/L was proposed.

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'Lead (II) compounds'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles