Academic literature on the topic 'Lead Exposure Associated'
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Journal articles on the topic "Lead Exposure Associated"
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Mason, Lisa H., Jordan P. Harp, and Dong Y. Han. "Pb Neurotoxicity: Neuropsychological Effects of Lead Toxicity." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/840547.
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Neurotoxicity is a term used to describe neurophysiological changes caused by exposure to toxic agents. Such exposure can result in neurocognitive symptoms and/or psychiatric disturbances. Common toxic agents include heavy metals, drugs, organophosphates, bacterial, and animal neurotoxins. Among heavy metal exposures, lead exposure is one of the most common exposures that can lead to significant neuropsychological and functional decline in humans. In this review, neurotoxic lead exposure's pathophysiology, etiology, and epidemiology are explored. In addition, commonly associated neuropsychological difficulties in intelligence, memory, executive functioning, attention, processing speed, language, visuospatial skills, motor skills, and affect/mood are explored.
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Pacheco-Tovar, Deyanira, María-Guadalupe Pacheco-Tovar, Esperanza Avalos-Díaz, Juan-José Bollain-y-Goytia, María-Elena Pérez-Pérez, Roxana Ramírez-Sandoval, Argelia López-Luna, and Rafael Herrera-Esparza. "Associated Autoimmunity and Lead Exposure in Childhood." International Journal of Immunology 9, no. 1 (2021): 16. http://dx.doi.org/10.11648/j.iji.20210901.14.
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Hipkins, Karen L., Barbara L. Materna, Susan F. Payne, and Luz C. Kirsch. "Family Lead Poisoning Associated with Occupational Exposure." Clinical Pediatrics 43, no. 9 (November 2004): 845–49. http://dx.doi.org/10.1177/000992280404300909.
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Thomson, Ruth M., and Gareth J. Parry. "Neuropathies associated with excessive exposure to lead." Muscle & Nerve 33, no. 6 (2006): 732–41. http://dx.doi.org/10.1002/mus.20510.
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Isidra, Hernández-Serrato Ma, Mendoza-Alvarado Laura R, Rojas-Martínez Rosalba, González-Garza Carlos, Jennifer Meghan Hulme, and Olaiz-Fernández Gustavo. "Factors associated with lead exposure in Oaxaca, Mexico." Journal of Exposure Science & Environmental Epidemiology 13, no. 5 (September 2003): 341–47. http://dx.doi.org/10.1038/sj.jea.7500282.
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Agier, Lydiane, Xavier Basagaña, Carles Hernandez-Ferrer, Léa Maitre, Ibon Tamayo Uria, Jose Urquiza, Sandra Andrusaityte, et al. "Association between the pregnancy exposome and fetal growth." International Journal of Epidemiology 49, no. 2 (March 13, 2020): 572–86. http://dx.doi.org/10.1093/ije/dyaa017.
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Abstract Background Several environmental contaminants were shown to possibly influence fetal growth, generally from single exposure family studies, which are prone to publication bias and confounding by co-exposures. The exposome paradigm offers perspectives to avoid selective reporting of findings and to control for confounding by co-exposures. We aimed to characterize associations of fetal growth with the pregnancy chemical and external exposomes. Methods Within the Human Early-Life Exposome project, 131 prenatal exposures were assessed using biomarkers and environmental models in 1287 mother–child pairs from six European cohorts. We investigated their associations with fetal growth using a deletion-substitution-addition (DSA) algorithm considering all exposures simultaneously, and an exposome-wide association study (ExWAS) considering each exposure independently. We corrected for exposure measurement error and tested for exposure–exposure and sex–exposure interactions. Results The DSA model identified lead blood level, which was associated with a 97 g birth weight decrease for each doubling in lead concentration. No exposure passed the multiple testing-corrected significance threshold of ExWAS; without multiple testing correction, this model was in favour of negative associations of lead, fine particulate matter concentration and absorbance with birth weight, and of a positive sex-specific association of parabens with birth weight in boys. No two-way interaction between exposure variables was identified. Conclusions This first large-scale exposome study of fetal growth simultaneously considered >100 environmental exposures. Compared with single exposure studies, our approach allowed making all tests (usually reported in successive publications) explicit. Lead exposure is still a health concern in Europe and parabens health effects warrant further investigation.
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Kanwal, Sandeep Kumar, and Virendra Kumar. "High Prenatal and Postnatal Lead Exposure Associated Lead Encephalopathy in an Infant." Indian Journal of Pediatrics 78, no. 11 (June 10, 2011): 1420–23. http://dx.doi.org/10.1007/s12098-011-0445-6.
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Patočka, Jiří. "Organic Lead Toxicology." Acta Medica (Hradec Kralove, Czech Republic) 51, no. 4 (2008): 209–13. http://dx.doi.org/10.14712/18059694.2017.26.
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Lead is one of the oldest known and most widely studied occupational and environmental poison. Despite intensive study, there is still debate about the toxic effects of lead, both from low-level exposure in the general population owing to environmental pollution and historic use of lead in paint and plumbing and from exposure in the occupational setting. Significant position have organic lead compounds used more than 60 years as antiknock additives in gasoline. Chemical and toxicological characteristics of main tetraalkyl leads used as gasoline additives are discussed in this article. The majority of industries historically associated with high lead exposure have made dramatic advances in their control of occupational exposure. However, cases of unacceptably high exposure and even of frank lead poisoning are still seen, predominantly in the demolition and tank cleaning industries. Nevertheless, in most industries blood lead levels have declined below levels at which signs or symptoms are seen and the current focus of attention is on the subclinical effects of exposure. The significance of some of these effects for the overt health of the workers is often the subject of debate. Inevitably there is pressure to reduce lead exposure in the general population and in working environments, because current studies show that no level of lead exposure appears to be a ‘safe’ and even the current ‘low’ levels of exposure, especially in children, are associated with neurodevelopmental deficits.
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Khalid, Madiha, and Mohammad Abdollahi. "Epigenetic modifications associated with pathophysiological effects of lead exposure." Journal of Environmental Science and Health, Part C 37, no. 4 (August 12, 2019): 235–87. http://dx.doi.org/10.1080/10590501.2019.1640581.
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Anis, Tarek H., Ahmed ElKaraksy, Taymour Mostafa, Amr Gadalla, Hager Imam, Lamya Hamdy, and Omayma Abu el-Alla. "Chronic Lead Exposure may be Associated with Erectile Dysfunction." Journal of Sexual Medicine 4, no. 5 (September 2007): 1428–36. http://dx.doi.org/10.1111/j.1743-6109.2007.00587.x.
Full textDissertations / Theses on the topic "Lead Exposure Associated"
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McIntosh, M. J. "Investigations into the neurochemical aberrations associated with lead exposure." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381488.
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Von, Schirnding Yasmin Elizabeth Roberta. "Environmental lead exposure among inner-city Cape Town children : a study of associated risk factors." Doctoral thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/15847.
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Bibliography: pages 284-306.Risk factors for lead exposure among children in South Africa have not been well documented. This study elucidated important factors which co-vary with lead in increasing children's risk of exposure. Two study designs were used. First, a cross-sectional analytical study involving first grade school children was executed. Venous blood samples from children were analysed for lead using atomic absorption spectrophotometry. In addition other haematological and anthropometric measurements were conducted. A pre-tested questionnaire administered to parents identified risk factors for lead exposure. Statistical analyses, including log-linear models, were used to determine the relationships between biological, environmental, social factors and blood lead. In an environmental study, daily air and dust samples were collected over a year from several sites in the study area, contemporaneously with the blood and questionnaire surveys. Spatial and temporal variations in atmospheric lead were determined. In stage two a case control study was carried out to determine whether risk factors for lead exposure differed among cases (blood lead ≥ 24 ug/dl) and controls (blood lead ≤ 14 ug/dl). Levels of lead in air, water, paint and dust samples from children's homes were determined and the state of housing evaluated. Home interviews were conducted with parents to assess the role of economic, demographic, cultural, and behavioural factors in increasing children's risk. 13% of coloured children, but no white children were identified with blood lead levels ≥ 25 ug/dl. Air lead levels ranged from< 0.5 ug/m³ to> 1.5 ug/m³ and dust lead levels from< 550 ppm to> 3 000 ppm. Environmental lead levels were significantly elevated near heavy traffic, particularly during winter months. Baseline exposure was of significance in influencing blood lead levels of children attending schools in direct proximity to heavy traffic, where blood lead levels were elevated. In cases, direct inhalation of aerosols, and ingestion of lead in water were not found to be important risk factors. Hand contamination and mouthing were associated with increased risk. Sources of elevated lead were found in the homes of both cases and controls, but were not accessible in the homes of controls. A conceptual framework for lead exposure in children is proposed, to illustrate how social and environmental factors may act to increase risk. The results have implications for primary and secondary prevention strategies aimed at the community.
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Ortinero, Cesar Villaflor. "In vitro and in vivo investigations of lead-induced changes in membrane protein expression and assessment of risks associated with children's exposure to environmental lead." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/161008.
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LODWICK, CAMILLE JANAE. "MATHEMATICAL SIMULATIONS OF PHOTON INTERACTIONS USING MONTE CARLO ANALYSIS TO EVALUATE THE UNCERTAINTY ASSOCIATED WITH IN VIVO K X-RAY FLUORESCENCE MEASUREMENTS OF STABLE LEAD IN BONE." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1059400723.
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Hsieh, Tien-Hui, and 謝天惠. "Whole exome sequencing detects the genotypes (SNPs) to be associated with prolonged QT interval and lead exposure." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/c5934d.
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碩士高雄醫學大學
公共衛生學系公共衛生學碩士班
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Objective: This study aims to discuss the relationship between lead level in the blood, prolonged QT interval and genes related to prolonged QT interval among lead-exposed and non-exposed workers in Taiwan. Materials and methods: The first group included two lead-exposed subjects who work in battery factory. The second group included two non-exposed subjects as reference. This is a cross sectional study that subjects received health examination, electrocardiograms examination and questionnaire annually. This study interpreted QT interval by using 12-lead electrocardiograms, and we extracted DNA from all subjects, then did the whole exome sequencing which could comprehensively analyzed fifteen genes related to prolonged QT interval. Results: After the descriptive analysis of this study, it was found that SLMAP(rs170***) genotype of the T allele may be affected by lead exposure and increase the risk of prolonged QT interval. In addition, there are not significantly correlated between others variation of genes of prolonged QT interval and lead exposure, as it could not prove that distribution of prolonged QT interval is affected by lead exposure from its genotypes. Conclusions: SLMAP(rs170***) is possibly associated with lead exposure to increase the risk of prolonged QT interval.
Books on the topic "Lead Exposure Associated"
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Institute, Battelle Memorial, and United States. Environmental Protection Agency. National Program Chemicals Division. Technical Branch, eds. Lead exposure associated with renovation and remodeling activities.: Worker characterization and blood-lead study of R&R workers who specialize in renovation of old or historic homes. Washington, D.C: The Branch, 1999.
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Syed, Almas, Robert Evans Heithaus, and Chet R. Rees. Reducing Operator Exposure Using Suspended Radiation Protection System. Edited by S. Lowell Kahn, Bulent Arslan, and Abdulrahman Masrani. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199986071.003.0105.
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The increasing utilization of radiation for diagnostic and therapeutic procedures has provided impetus for improved strategies of radiation protection for interventionalists. The associated discomfort, disability, and career-shortening effects of lead aprons for heavy fluoroscopy users have served as an impetus for the development of lighter and more comfortable models. A suspended radiation protection system employs the use of a “weightless” shield resembling a thick large lead apron with head shield and arm shields. The shield moves with the operator like a garment, providing extensive protection without orthopedic strain or discomfort while maintaining full user functionality. Utilization of a suspended radiation protection system provides the operator with optimum radiation protection, without any additional weight, and maintains procedural flexibility.
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Beninger, Richard J. Drug abuse and incentive learning. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198824091.003.0010.
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Drug abuse and incentive learning explains how abused drugs, including nicotine, ethanol, marijuana, amphetamine, cocaine, morphine, and heroin, produce conditioned place preference and are self-administered; dopamine receptor antagonists block these effects. Stimuli that become reliable predictors of drug reward produce burst firing in dopaminergic neurons, but the drug retains its ability to activate dopaminergic neurons. Thus, repeated drug users experience two activations of dopaminergic neurotransmission, one upon exposure to the conditioned stimuli signaling the drug and another upon taking the drug. This may lead to long-term neurobiological changes that contribute to withdrawal and addiction. Withdrawal can be remediated by abstinence but this does not reduce the conditioned incentive value of cues associated with drug taking; those cues can lead to relapse. Effective treatment will include detoxification and systematic exposure to drug taking-associated conditioned incentive stimuli in the absence of drug so that those stimuli lose their ability to control responses.
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Summary and assessment of published information on determining lead exposures and mitigating lead hazards associated with dust and soil in residential carpets, furniture, and forced air ducts. Washington, DC: National Program Chemicals Division, Office of Pollution Prevention and Toxics, Office of Prevention, Pesticides, and Toxic Substances, U.S. Environmental Protection Agency, 1997.
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Hainline, Brian, Lindsey J. Gurin, and Daniel M. Torres. Concussion. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190937447.001.0001.
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Concussion is a type of mild traumatic brain injury, is common, and occurs both in sport and as a result of falls or accidents. Concussion has become an increasingly recognized public health concern, largely driven by prominent media coverage of athletes who have sustained concussion. Although much has been written about this condition, its natural history is still not well understood, and practitioners are only now beginning to recognize that concussion often manifests in different clinical domains. These may require targeted treatment in and of themselves; otherwise, persistent post-concussive symptoms may develop. Although most individuals who sustain a concussion recover, and although concussion is a treatable condition, it is important that concussion be managed early and comprehensively to avoid a more prolonged clinical trajectory. A relatively recent term often used in the setting of concussion is repetitive head impact exposure—a biomechanical force applied to the head that does not generate a clinical manifestation of concussion, but may result in structural brain changes. Although it is often assumed that repetitive head impact exposure leads to long-term neurological sequelae, the science to document this assumption is in its infancy. Repeated concussions may lead to depression or cognitive impairment later in life, and there is an emerging literature that repeated concussion and repetitive head impact exposure are associated with chronic traumatic encephalopathy or other neurodegenerative diseases. Currently there is no known causal connection between concussion, repetitive head impact exposure, and neurodegeneration, although this research is also still in its infancy.
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Doyle, Lauren R., and Sarah N. Mattson. Behavioral Teratogenic Effects of Alcohol: Focus on Neurobehavioral Disorder Associated With Prenatal Alcohol Exposure. Edited by Thomas H. Ollendick, Susan W. White, and Bradley A. White. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190634841.013.39.
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Prenatal exposure to teratogens may alter fetal development and significantly impact later life. Perhaps the best known teratogen is alcohol; prenatal alcohol exposure causes a broad range of effects that can cause lifelong impairment. Of greatest significance are the functional impairments in behavior and cognition. Recognition of these impairments led to the inclusion of the neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE) in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders under “conditions for further study.” This proposed diagnosis captures the significant neurodevelopmental and mental health impacts associated with prenatal alcohol exposure and requires impairment in neurocognitive functioning, self-regulation, and adaptive functioning. This chapter reviews clinical impacts of prenatal alcohol exposure, with particular focus on ND-PAE. Methods for comprehensively assessing fetal alcohol spectrum disorders, specifically ND-PAE, are discussed as well as preliminary evidence for implementing effective interventions with these individuals.
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Wernli, Karen J., and Erin J. Bowles. Breast Cancer Screening: Evidence and Recommendations. Edited by Christoph I. Lee, Constance D. Lehman, and Lawrence W. Bassett. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190270261.003.0002.
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Breast cancer screening in the United States was first recommended to women in 1976. Over the past decade, mammography screening has changed from film screen mammography to primarily digital mammography, which, as of 2016, accounts for over 97% of all mammograms performed in the United States. Several systematic reviews, which have included results from up to 9 randomized clinical trials from the United States, Europe, and Canada, have demonstrated a reduced risk of breast cancer mortality associated with breast cancer screening. Potential harms from breast cancer screening include false-positive mammograms (which may lead to unnecessary additional imaging and benign breast biopsies), overdiagnosis, and radiation exposure. This chapter summarizes evidence from randomized controlled trials for mortality benefit; current society and task force recommendations for mammography screening; evaluation of the evidence; risk–benefit analysis; and supplemental screening in high-risk women.
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Jayne, David. Treatment of ANCA-associated vasculitis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0132.
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The goals of treatment in anti-neutrophil cytoplasm antibody (ANCA) vasculitis are to stop vasculitic activity, to prevent vasculitis returning, and to address longer-term comorbidities caused by tissue damage, drug toxicity, and increased cardiovascular and malignancy risk. Cyclophosphamide and high-dose glucocorticoids remain the standard induction therapy with alternative immunosuppressives, such as methotrexate or azathioprine, to prevent relapse. Refractory disease resulting from a failure of induction or remission maintenance therapy requires alternative agents and rituximab has been particularly effective. Replacement of cyclophosphamide by rituximab for remission induction is supported by recent evidence. Additional therapy with intravenous methylprednisolone and plasma exchange is employed in severe presentations with failing vital organ function. Drug toxicity contributes to comorbidity and mortality and has led to newer regimens with reduced cyclophosphamide exposure. Glucocorticoid toxicity remains a major problem, with controversy over the rapidity with which glucocorticoids can be reduced or withdrawn. Disease relapse occurs in 50% and requires early detection at a stage when it will not adversely affect outcomes. Rates of cardiovascular disease and malignancy are higher than in control populations but strategies to reduce their risk, apart from cyclophosphamide-sparing regimens, have not been developed. Thromboembolic events occur in 10% and may be linked to the recently identified autoantibodies to plasminogen and tissue plasminogen activator. Outcomes of vasculitis depend heavily on the level of tissue damage at diagnosis, especially renal dysfunction, but are also influenced by patient age, ANCA subtype, disease extent, and response to therapy. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)is treated along similar principles to granulomatosis with polyangiitis (GPA) and microscopic polyangiitis but the persistence of steroid-dependent asthma in over one-third and differences in pathogenesis has suggested alternative treatment approaches. Chronic morbidity results from tissue damage and is especially common in the upper and lower respiratory tract and kidneys. Tracheobronchial disease is a severe late complication of GPA, while deafness, nasal obstruction, and chronic sinusitis are sequelae of nasal and ear vasculitis. Chronic infection of damaged epithelial surfaces acts as a drive for vasculitic activity and adequate infection control is necessary for stable remission. Chronic kidney disease can stabilize for many years but the risks of endstage renal disease (ESRD) are increased by acute kidney injury at presentation or renal relapse. Renal transplantation is successful, with similar outcomes to other causes of ESRD.
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Zaitchik, Benjamin F. Climate and Health across Africa. Oxford University Press, 2017. http://dx.doi.org/10.1093/acrefore/9780190228620.013.555.
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Humans have understood the importance of climate to human health since ancient times. In some cases, the connections appear to be obvious: a flood can cause drownings, a drought can lead to crop failure and hunger, and temperature extremes pose a risk of exposure. In other cases, the connections are veiled by complex or unobserved processes, such that the influence of climate on a disease epidemic or a conflict can be difficult to diagnose. In reality, however, all climate impacts on health are mediated by some combination of natural and human dynamics that cause individuals or populations to be vulnerable to the effects of a variable or changing climate.Understanding and managing negative health impacts of climate is a global challenge. The challenge is greater in regions with high poverty and weak institutions, however, and Africa is a continent where the health burden of climate is particularly acute. Observed climate variability in the modern era has been associated with widespread food insecurity, significant epidemics of infectious disease, and loss of life and livelihoods to climate extremes. Anthropogenic climate change is a further stress that has the potential to increase malnutrition, alter the distribution of diseases, and bring more frequent hydrological and temperature extremes to many regions across the continent.Skillful early warning systems and informed climate change adaptation strategies have the potential to enhance resilience to short-term climate variability and to buffer against negative impacts of climate change. But effective warnings and projections require both scientific and institutional capacity to address complex processes that are mediated by physical, ecological, and societal systems. Here the state of understanding climate impacts on health in Africa is summarized through a selective review that focuses on food security, infectious disease, and extreme events. The potential to apply scientific understanding to early warning and climate change projection is also considered.
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Patisaul, Heather B., and Scott M. Belcher. The Chemical Landscape. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780199935734.003.0001.
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This introductory chapter aims to provide an initial overview of the connections between current trends of increasing prevalence of behavioral disorders in children, which persist through adulthood, and increasing exposures to man-made environmental chemicals. A foundational definition of endocrine disruptors is presented and is contrasted with traditional definitions of reproductive and endocrine toxicity. Historical and current examples of specific disorders in humans and wildlife species associated with endocrine disruptor exposures are presented. Current trends of the rapid development of new chemicals and how they come to market with little or no safety testing are examined. Using lead as a case study of how chemical policy has been driven by corporate interests, rather than public health and safety, the chapter introduces the origins of chemical safety and policy based on proof of harm. Key concepts and controversy surrounding the acceptance of the “endocrine disruptor hypothesis” are examined.
Book chapters on the topic "Lead Exposure Associated"
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Vieira, Adriana, Ana Gramacho, Dora Rolo, Nádia Vital, Maria João Silva, and Henriqueta Louro. "Cellular and Molecular Mechanisms of Toxicity of Ingested Titanium Dioxide Nanomaterials." In Advances in Experimental Medicine and Biology, 225–57. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-88071-2_10.
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AbstractAn exponential increase in products containing titanium dioxide nanomaterials (TiO2), in agriculture, food and feed industry, lead to increased oral exposure to these nanomaterials (NMs). Thus, the gastrointestinal tract (GIT) emerges as a possible route of exposure that may drive systemic exposure, if the intestinal barrier is surpassed. NMs have been suggested to produce adverse outcomes, such as genotoxic effects, that are associated with increased risk of cancer, leading to a concern for public health. However, to date, the differences in the physicochemical characteristics of the NMs studied and other variables in the test systems have generated contradictory results in the literature. Processes like human digestion may change the NMs characteristics, inducing unexpected toxic effects in the intestine. Using TiO2 as case-study, this chapter provides a review of the works addressing the interactions of NMs with biological systems in the context of intestinal tract and digestion processes, at cellular and molecular level. The knowledge gaps identified suggest that the incorporation of a simulated digestion process for in vitro studies has the potential to improve the model for elucidating key events elicited by these NMs, advancing the nanosafety studies towards the development of an adverse outcome pathway for intestinal effects.
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Evans, Hugh L. "Cognitive and Behavioral Manifestations of Lead." In Cognitive and Behavioral Abnormalities of Pediatric Diseases. Oxford University Press, 2010. http://dx.doi.org/10.1093/oso/9780195342680.003.0071.
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The link between exposure to lead and children’s cognitive problems was implied in the earliest medical reports of frank lead poisoning of young children in Australia in the 1800s (Lin-Fu 1992). Children with acute severe toxicity of lead (Pb) are now rarely seen in the United States. However, millions of children may have subclinical neurobehavioral disorders associated with chronic low-level exposure to lead, representing a major public health concern (Bellinger 2008a). Lead is a nonessential metal that is recognized as a source of toxic exposure, with the developing nervous system particularly vulnerable. Because of this, U.S. regulations limiting the lead content of gasoline and household paint have led to a gradual reduction of the average blood lead concentration of Americans over the last three decades. Average blood lead levels of children in the United States dropped an estimated 78% from 1976 to 1991 (Brody et al. 1994; Caldwell et al. 2009). Despite these reductions in exposure to lead, new advances in research techniques have documented harmful consequences associated with lower blood lead levels. This raises the possibility that there is no threshold for occurrence of lead-induced toxicity. Bellinger (2008a) refers to “the silent pandemic of neurodevelopmental disorders resulting from children’s continuing exposure to low levels of lead.” The developing brain may be more sensitive to exposure to lead than the adult. Since the pioneering work of Needleman and colleagues (1979), a large scientific literature has documented the deleterious effects of pre- and neonatal exposure to lead. Decrements in IQ scores have proven to be among the most sensitive and consistent consequences of a child’s exposure to lead, but other cognitive and behavioral changes have been described as well, including attention-deficit hyperactivity disorder (ADHD). Among the important current sources of children’s exposure to lead is household dust (Dixon et al. 2009) the lead content in old water pipes, batteries, and from contamination by numerous industrial processes. Pre and postnatal exposure to cigarette smoke is a cofactor with lead exposure in children’s conduct disorders (Braun et al. 2008). Diagnosis of lead-induced disorders involves the determination of exposure to lead and the atomic absorption assay of lead in whole blood.
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Lalwani, Kiran, Caroline French, and Christine Richardson. "Mouse Models to Understand Mutagenic Outcomes and Illegitimate Repair of DNA Damage." In Mutagenesis and Mitochondrial-Associated Pathologies [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.103929.
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Maintenance of genome integrity is critical to prevent cell death or disease. Illegitimate repair of chromosomal DNA breaks can lead to mutations and genome rearrangements which are a well-known hallmark of multiple cancers and disorders. Endogenous causes of DNA double-strand breaks (DSBs) include reactive oxygen species (ROS) and replication errors while exogenous causes of DNA breaks include ionizing radiation, UV radiation, alkylating agents, and inhibitors of topoisomerase II (Top2). Recent evidence suggests that a growing list of environmental agents or toxins and natural dietary compounds also cause DNA breaks. Understanding the consequences of exposure to a broad spectrum of DSB-inducing agents has significant implications for understanding mutagenicity, genome stability and human health. This chapter will review in vivo mouse models designed to measure DNA damage and mutagenicity, and illegitimate repair of DNA DSBs caused by exposure to environmental agents.
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"Learning-induced modulation of neural cell adhesion molecule polysialylation state as a biomarker of prior inorganic lead exposure during the early postnatal period." In Biomarkers of Environmentally Associated Disease, 235–48. CRC Press, 2002. http://dx.doi.org/10.1201/9781420032208-17.
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Murphy, Keith, Ciaran Regan, and Helen Gallagher. "Learning-induced modulation of neural cell adhesion molecule polysialylation state as a biomarker of prior inorganic lead exposure during the early postnatal period." In Biomarkers of Environmentally Associated Disease. CRC Press, 2002. http://dx.doi.org/10.1201/9781420032208.sec3.
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Währborg, Peter, Panagiota Pervanidou, and George P. Chrousos. "The physiology of stress and stress recovery." In Oxford Textbook of Nature and Public Health, edited by Matilda van den Bosch and William Bird, 33–39. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198725916.003.0033.
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Stress (i.e. the state of threatened homeostasis), is normally associated with adaptive physical and behavioural changes that promote individual survival. Successful maintenance of homeostasis leads to the state of eustasis, which represents health. The prolonged, excessive, or deficient response of the stress system to stress, however, may lead to a state of dyshomeostasis or cacostasis, which may lead to physical and mental health problems. Although research has focused on the detrimental effects of stress, only a few studies have been done on positive stress exposure adaptations. Increased resilience, post-traumatic psychological growth, and increased empathy may benefit chronically stressed individuals, enhancing their abilities to cope with distress. Therapeutic efforts in the treatment of short- or long-term stress aims at reducing its effect on neuroendocrine responses, behaviour changes, and so on. Community investments and interventions should focus on reducing threats and promoting positive adaptation during and after traumatic stress exposures.
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Jeffery, Katie. "Case 39." In Oxford Case Histories in Infectious Diseases and Microbiology, edited by Katie Jeffery, 269–76. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198846482.003.0039.
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Viral infection in pregnancy can lead to adverse outcomes for both the mother and the foetus. This chapter examines the steps to be taken on exposure to viruses associated with rash illness in pregnancy. Consideration is given to the important points in the history, which viral infections are of concern in pregnancy (varicella-zoster, parvovirus B19, rubella, measles, and Zika), the possible outcomes of infection, diagnostic approaches, and the management of a confirmed case of Parvovirus B19 infection.
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Lin, Chin, Rui Imamura, and Felipe Fregni. "Confounders and Using the Method of Propensity Scores." In Critical Thinking in Clinical Research, edited by Raquel Ajub Moyses, Valeriam Angelim, Scott Evans, Rui Imamura, and Felipe Fregni, 362–76. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199324491.003.0017.
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This chapter explores the important issue of confounding in observational studies. The potential imbalances that result for not controlling assignment of treatment or exposure may lead to imbalance of variables that are associated with both treatment and intervention (or exposure) thus confounding results. Therefore, in this context, a potential relationship between an intervention and an outcome could be invalid. This chapter therefore explains basic definitions of confounding and presents some methods to control for confounders, highlighting the use of the propensity score, which is considered a robust method for this purpose. Different techniques of adjustment using propensity score (matching, stratification, regression, and weighting) are also discussed. This chapter concludes with a case discussion about confounding and how to address it.
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Chiu, Shannon Y., and Irene A. Malaty. "Tardive Dystonia and Dyskinesia Responsive to Deep Brain Stimulation." In Deep Brain Stimulation, edited by Shilpa Chitnis, Pravin Khemani, and Michael S. Okun, 233–38. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780190647209.003.0044.
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Tardive disorders encompass phenomenologically diverse delayed-onset persistent involuntary motor symptoms associated with exposure to dopamine receptor blocking agents. Two common tardive disorders encountered in the clinical setting include tardive dyskinesia and tardive dystonia. This chapter presents a patient with severe refractory tardive dyskinesia and also tardive dystonia, manifesting as frequent and disabling retropulsion. He initially underwent bilateral globus pallidus interna (GPi) deep brain stimulation (DBS) but was found to have lead migration secondary to his severe hyperkinetic movements. He had persistent symptoms despite lead revision and ultimately required bilateral subthalamic nucleus (STN) rescue DBS implantation. The rescue procedure was synergistic with the initial GPi DBS and markedly improved his symptoms. Severe tardive dyskinesia and dystonia may respond to bilateral GPi DBS, and if necessary, rescue STN DBS can be added.
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Yazar, Selma. "Endocrine Disruptors and Infertility." In Poisoning - The Toxicity of Environmental Pollutants [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104403.
Full textAbstract:
Endocrine-disrupting chemicals (EDC) are known to interfere the body’s endocrine system. EDCs can also be considered as industrial chemicals namely pesticides, cleaning materials, plastics, heavy metals, and cosmetics. Most of these compounds particularly at low doses, occurring in complex mixtures, have been reported as emerging contaminants. EDCs are currently present in environment (water, diet, food contact materials, personal care products, etc). The adverse effects of exposure to EDCs have already been extensively described such as infertility, cancers, disrupted thyroid function, neurological disorders, obesity, metabolic syndrome. EDCs may be blamed for increasing the human reproductive disorders especially infertility. This is a serious public health problem that should not be ignored. This chapter aims to summarize the major scientific advances in human infertility associated with exposure to EDCs with epidemiological and experimental evidence. The chemicals covered in this chapter are heavy metals (lead), pesticides (pyrethroids), and cosmetics (UV filters).
Conference papers on the topic "Lead Exposure Associated"
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Bolander, Richard, Cynthia Bir, and Pamela VandeVord. "Intracranial Pressure Measurement Within the Rat Skull is Sensitive to Shock Wave Intensity and Weight of the Specimen." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53590.
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Blast associated injuries have been quantified into different classes based on the type of trauma that they create [1]. Of these types of trauma, the neuropathology invoked by shock wave exposure is the most ambiguous [1]. The properties associated with shock wave exposure have lead to multiple hypothesized mechanisms for brain trauma including: acceleration-based damage, a thoracic squeeze resulting in pressure pulses to the brain, or transference of energy from the shock wave into the brain via the skull [2, 3].
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Schroer, Carsten, Valentyn Tsisar, Olaf Wedemeyer, Aleksandr Skrypnik, and Jürgen Konys. "Corrosion in Steel T91 Caused by Flowing Lead–Bismuth Eutectic at 400°C and 10−7 Mass% Solved Oxygen." In 2016 24th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/icone24-60845.
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Specimens produced from two different heats of ferritic/martensitic steel T91 were exposed to oxygen-containing flowing lead–bismuth eutectic (LBE) at 400 °C, 10−7 mass% solved oxygen and flow velocity of 2 m/s, for exposure times between around 1000 and 13,000 h. The occurring phenomena were analyzed and quantified using metallographic cross sections prepared after exposure. Oxidation causes a material loss of <10 μm after 13,000 h, while corrosion initiated by the solution of the steel elements may generally proceed around 15 to 30 μm deep into the material in the same amount of time. Oxide scales formed on both heats of T91 tend to buckle and detach. In the case of one of the investigated heats, a singular event of exceptionally severe solution-based corrosion was observed, with associated local material loss around 1.2 mm after 13,000 h. The results are compared especially with findings at 450 and 550 °C and otherwise similar conditions as well as austenitic steels tested in the identical experimental run.
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Duarte, Joana, Jacqueline Castelo Branco, Fernanda Rodrigues, and J. Santos Baptista. "Short review on occupational noise exposure in the extractive industry and similar works." In 4th Symposium on Occupational Safety and Health. FEUP, 2021. http://dx.doi.org/10.24840/978-972-752-279-8_0015-0020.
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Introduction: Occupational noise is still a matter within the industrial practice with nefarious consequences on the worker’s health. Pulmonary diseases, cardiovascular problems, disturbances in sleep, fatigue, and, in the worst-case scenarios, hearing loss (this one with a permanent character) are some of the most common adverse effects reported in the literature. This issue covers itself in even more significant concern when analysing the mining industry context. Almost every operation works as a potential noise source, not only for the workers but also for the surrounding populations. Objective: To identify the exposure setting to occupational noise in the extractive industry and similar works (i.e. earthworks), particularly related to tasks and equipment. Methodology: The Preferred reporting items for systematic reviews and meta-analyses (PRISMA) was used as a guideline to help conduct the research and report of this work. The most relevant keywords were selected and later combined in the selected databases and multidisciplinary academic journals in the first phase. After, the articles were filtered with a set of exclusion criteria, to know: 1) Publication year, 2) Document type, 3) Source type, and 4) Language. The subsequent stage was to determine, within the remaining articles, the pertinence of each study and its later inclusion in the study. Each set of data was then classified according to the measurement context, and the results were analysed. Results and discussion: In the records’ identification phase, a total of 1148 papers were recovered. By applying the previously mentioned exclusion criteria, 547 were removed related to publication year, 146 due to document type, 12 related to source type and 25 because of language. Additionally, 360 records were excluded because were not in accordance with the proposed objective, 25 were duplicate articles, and 7 had no full-text available. From the last analysis, 11 more papers were excluded, which lead to a final result of 15 included studies. According to theoccupational noise measurements set, the records were divided into four categories: activity, equipment, job category, and working area. Different equipment was associated with high noise levels: crusher –between 85.6 and 104 dB, trucks and bulldozes –above 100 dB, and shovel –103 dB, whereas the only analysed activity was blasting, where studies concluded that increasing distance leads to lower noise measurement values. Conclusions: Considering this research, although it was possible to identify the tasks and equipment usually associated with occupational noise in the extractive industry, a lot of work still needs to be done, especially data analysis. However, this research serves as a starting point for future study.
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Dolan, E. B., T. J. Vaughan, G. L. Niebur, D. Tallon, and L. M. McNamara. "Understanding the Effects of Thermal Elevations Associated With Orthopedic Intervention: An Experimental and Computational Investigation." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14159.
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Specialized surgical cutting instruments are required to provide orthopedic surgeons with access to joints of the body, without causing extensive harm to native tissue, thus enhancing post-operative outcome. Orthopaedic intervention inevitably exposes bone tissue to elevated temperatures due to mechanical abrasion. Elevated temperatures lead to thermal necrosis and apoptosis of bone cells, surrounding soft tissue, bone marrow and stem cells crucial for postoperative healing (1–4). Thermally damaged bone tissue is subsequently resorbed and in severe cases replaced by connective tissue (2, 5) Bone thermal damage occurs when the local temperature exceeds a thermal threshold, largely recognised as ≥47°C (4, 6). Furthermore, it has been proposed that the area of bone to experience thermal damage is directly proportional to the duration of exposure to the heat source (7, 8). However, precise thermal elevations occurring throughout bone during surgical cutting are not well defined. It is also unclear whether temperatures generated in osteocytes in vivo are sufficient to induce cellular responses. Experimental analysis of temperature generation throughout bone is challenging due to its complex heterogeneous composition. There is a specific need for advanced 3D computational models that incorporate multi-scale variability in both bone tissue composition and thermal properties to predict how organ level thermal elevations are distributed throughout bone cells and tissue during orthopaedic cutting procedures.
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Han, Muyue, Jing Zhao, and Lin Li. "Emissions of Volatile Organic Compounds From 4D Printing and Associated Control Strategies Towards Workplace Safety." In ASME 2021 16th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/msec2021-63540.
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Abstract The integration of additive manufacturing technologies with stimuli-responsive shape memory materials allows the dynamic self-adaptation of fabricated parts upon exposure to external stimulations. The additional dimension of time inspires the concept of four-dimensional printing technology. However, the emerging feedstock materials and the employment of external stimuli in 4D printing are also associated with new workplace hazards and occupational health concerns. Current evaluation studies on additive manufacturing are mainly focused on the safety and health effects that originated from the part production phase and cannot be directly applied in 4D printing processes. In this study, the emissions of volatile organic compounds from stereolithography-based 4D printing process with thermo-responsive materials are targeted as the potential safety concern. Real-time total volatile organic compound monitoring is conducted during various production phases to align the emission sources with critical operating activities, including both operator interventions and machine operations. Comparative experiments are performed to evaluate the effectiveness of proposed emission control strategies. In particular, alterations in operation procedures such as stirring speed in material mixing and post-printing stimulation method can contribute positively to air emission control during manual operations. In addition, the installation of activated carbon fiber filters inside the machine build chamber can lead to a significant reduction of air emissions during part fabrication with an overall total volatile organic compound concentration reduction of 58.91%.
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Prueter, Phillip E., Ryan Jones, Jacki Hess, and Joel DeLuca. "Managing the Risks Associated With Operating a Hydrotreater Reactor With Possible High-Temperature Hydrogen Attack Damage." In ASME 2019 Pressure Vessels & Piping Conference. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/pvp2019-93533.
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Abstract High-temperature hydrogen attack (HTHA) is a damage mechanism that can detrimentally affect the service life of carbon steel and low-chrome pressure equipment in the petroleum refining and related industries. HTHA involves the diffusion of hydrogen into steel, where it chemically reacts with free carbon at high temperatures to produce methane. This methane then gets trapped inside small cavities and other material defects. Over time, the rising methane pressure in these cavities can cause damage at the material grain boundaries. To this end, long-term exposure to high-temperature hydrogen environments can lead to volumetric damage that can diminish the load carrying capability of pressure equipment and accelerate the propagation of crack-like flaws. There have been several known industry failures attributed to HTHA damage as well. This paper summarizes a case study of a detailed analytical evaluation of potential HTHA damage in a vintage C-0.5Mo hydrotreater reactor. The goal of this study is to quantify the severity of HTHA damage using methods developed as part of an ongoing, multi-year Joint Industry Project (JIP) to justify continued operation of the reactor until the earliest practical replacement opportunity. HTHA damage and crack growth predictions are carried out based on documented historical operating conditions. Additionally, sensitivity in predicted remaining life to anticipated future operating temperatures is considered. Furthermore, based on state-of-the-art non-destructive examination (NDE) methods, fracture mechanics-based minimum pressurization temperature (MPT) envelopes are generated to help guide start-up and shut-down procedures that mitigate the risk for brittle fracture. Practical recommendations are also provided to facilitate the interpretation of NDE findings and to implement on-going failure mitigation and risk management strategies, including the development of Integrity Operating Windows (IOWs), for the reactor until planned replacement.
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Griffith, Matthew, Daniel Brisach, Janelle Konchar, Stephen Petfield, Peter Popper, and James Glancey. "Polymer Composite-Based Vibration and Noise Emission Controls for Hand-Struck Impact Tools." In ASME 2007 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/detc2007-35699.
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Exposure to high noise levels may be the most common occupational hazard. Recent estimates suggest that as many as 30 million Americans are exposed to noise levels greater than the current safe limits for workplaces. At current durations of exposure, it is expected that 25% of these workers will develop permanent, noise-induced hearing loss. In many of these industrial environments, high levels of vibration also exist that can lead to several injuries and ailments. To address the adverse effects associated with the use of high noise emission impact tools, a study was initiated to develop and evaluate alternate tool designs that reduce the potential for hearing loss and vibration-related injuries. Recent work has focused on integrating advanced engineering polymers (composites) into tool designs for the purpose of eliminating direct metal-to-metal impact. This approach has several significant performance advantages including reduced operator discomfort due to hand-arm mechanical shock, reduced noise, and less danger from flying metal fragments. To quantify sound emission characteristics of these new designs, continuous sound pressure, maximum sound pressure, and maximum sound pressure level were measured using an array of five precision microphones each located 1 meter from the tool. Data was sampled at 40 kHz while test subjects operate both pneumatic tools and hand-struck tools. Frequency spectra of the sound pressure signals were examined for all tool treatments, and indicate that the addition of a polymer insert between metal impact components significantly reduces noise emission, especially at higher frequencies. Similar reductions were observed in vibration transmission in the hand and arm. As a result, tools that integrate polymer-based components may be operated for longer daily exposure times without inducing hearing loss or vibration-related injuries. Data from this study may also help auditory and ergonomic specialists in understanding impulse noise characteristics and exposure.
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Morbiducci, Umberto, Raffaele Ponzini, Matteo Nobili, Diana Massai, Franco M. Montevecchi, Danny Bluestein, and Alberto Redaelli. "Prediction of Shear Induced Platelet Activation in Prosthetic Heart Valves by Integrating Fluid–Structure Interaction Approach and Lagrangian-Based Blood Damage Model." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206162.
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Altered haemodynamics are implicated in the blood cells damage that leads to thromboembolic complications in presence of prosthetic cardiovascular devices, with platelet activation being the underlying mechanism for cardioemboli formation in blood flow past mechanical heart valves (MHVs). Platelet activation can be initiated and maintained by flow patterns arising from blood flowing through the MHV, and can lead to an enhancement in the aggregation of platelets, increasing the risk for thromboemboli formation. Hellums and colleagues compiled numerous experimental results to depict a locus of incipient shear related platelet activation on a shear stress – exposure time plane, commonly used as a standard for platelet activation threshold [1]. However, platelet activation and aggregation is significantly greater under pulsatile or dynamic condition relative to exposure to constant shear stress [2]. Previous studies do not allow to determine the relationship existing between the measured effect — the activation of a platelet, and the cause — the time-varying mechanical loading, and the time of exposure to it as might be expected in vivo when blood flows through the valve. The optimization of the thrombogenic performance of MHVs could be facilitated by formulating a robust numerical methodology with predictive capabilities of flow-induced platelet activation. To achieve this objective, it is essential (i) to quantify the link between realistic valve induced haemodynamics and platelet activation, and (ii) to integrate theoretical, numerical, and experimental approaches that allow for the estimation of the thrombogenic risk associated with a specific geometry and/or working conditions of the implantable device. In this work, a comprehensive analysis of the Lagrangian systolic dynamics of platelet trajectories and their shear histories in the flow through a bileaflet MHV is presented. This study uses information extracted from the numerical simulations performed to resolve the flow field through a realistic model of MHV by means of an experimentally validated fluid-structure interaction approach [3]. The potency of the device to mechanically induce activation/damage of platelets is evaluated using a Lagrangian-based blood damage cumulative model recently identified using in vitro platelet activity measurements [4,5].
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Cangue, F., and A. D'Oliveira. "Effect of Al on the Performance of Ni Based PTA Coatings." In ITSC2008, edited by B. R. Marple, M. M. Hyland, Y. C. Lau, C. J. Li, R. S. Lima, and G. Montavon. Verlag für Schweißen und verwandte Verfahren DVS-Verlag GmbH, 2008. http://dx.doi.org/10.31399/asm.cp.itsc2008p0366.
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Abstract Degradation of components that operate under elevated temperature and carburizing environments involves the diffusion of C and the precipitation of carbides. Industries have been seeking for materials that can withstand these service conditions. The present work aimed to develop coatings to address this challenge through the enrichment of a Ni based alloy with Al. An atomized Ni alloy without Al and different powder mixtures with 15 and 30wt%Al were deposited by PTA on a carbon steel. Coatings were analyzed in the as deposited condition and after temperature exposure in an air furnace and pack cementation tests at 650º and 850ºC. Vickers microhardness profiles under a 500gf load, X-ray diffraction, optical and scanning electronic microscopy were done Results revealed that the presence of Al lead to the development of a complex intermetallic phases which were associated with the enhanced metallurgical stability of the coatings under the tested temperatures. The superior performance of the coatings deposited with the powder mixture containing 30wt%Al after pack cementation was associated with the development of the NiAl intermetallic phase and of the oxide layer Al2O3 that stabilized the microstructure at the tested temperatures and reduced the diffusion of C.
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Lipscomb, Kristen, Nesrin Sarigul-Klijn, and Eric O. Klineberg. "Characterization of Lumbar-Level Spinal Fusion on the Whole Human Spine Under Vibrations." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66384.
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In the United States alone, 12–15% of the population will visit their physician for back pain problems each year, creating a direct annual cost of nearly $40 billion. Pain in the spine may be associated with spinal instability and intervertebral disc (IVD) degeneration. The causes of disc degeneration are not completely understood, but have been thought to be linked to excessive loading conditions and whole body vibrations. Patients not responding to non-operative treatment may be considered for surgical fusion. Vibrations of the spine near its resonant frequency are more likely to lead to spinal injury and subsequent pain. These vibrations may result from prolonged exposure to mechanical vibrations, for example from riding in vehicles. Little is understood about the effect of spine pathologies or treatment techniques on this frequency. While fusion procedure may aid in stabilizing the spine, it may also lead to changes in spine biomechanics. A high fidelity anatomically accurate whole spine finite element model was developed and utilized to examine vibration in the spine using modal analysis. Vibration modes and resonant frequencies were obtained in the healthy spine along with cases of lumbar spine disc degeneration and fusion at several levels, including L4-L5, L3-L5, L5-S, L4-S, and L3-S.
Reports on the topic "Lead Exposure Associated"
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Malkinson, Mertyn, Richard Witter, and Irit Davidson. Reduction of Reticuloendotheliosis in Foundation Breeding Flocks of Chickens: A Combined Immunological and Molecular Biological Approach. United States Department of Agriculture, February 1996. http://dx.doi.org/10.32747/1996.7613026.bard.
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Reticuloendotheliosis virus (REV) is an avian retrovirus that can cause immunosuppression, growth retardation and tumors. An attempt to define the extent of the economic damage to the poultry industry that it causes is discussed in this report. In addition to losses experienced by commercial laying flocks, reduced rates of hatchability and embryo developmental disorders were demonstrable due to vertical transmission of the virus. I. Eradication of REV In this project a comprehensive national program was applied for the eradication of REV from Israeli breeding stocks by the elimination of antibody-positive birds from the breeding program. The prevention of REV-infected breeders entering Israel was also implemented by serological examination of imported day-old chickens and turkeys for maternal antibody. At the same time commercial breeding flocks in Israel were surveyed routinely to measure the extent of environmental exposure to REV throughout Israel. II. Economic factors associated with vertical transmission on breeders and progeny It was observed that on some poultry farms exposure of breeding flocks to viral infection, if it occurs when the birds are immunocompetent, leads only to a seroconvertion event. In these flocks no differences were demonstrated between the performances of seronegative and seropositive birds. When the F1 generation was selected according to seronegativity of the parents, all the progeny were seronegative, indicating that tolerantly infected birds did not form a significant proportion of the parent flock. In sharp contrast, breeding flocks that became exposed to the virus about the point of lay or during the laying period, shed virus vertically for a brief period of time through the egg. Our epizootiological observations lead us to conclude that the progeny (laying pullets) becomes tolerantly infected and are immunosuppressed as they increase in age. Increased mortality and susceptibility to intercurrent diseases were recorded.
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Yahav, Shlomo, John McMurtry, and Isaac Plavnik. Thermotolerance Acquisition in Broiler Chickens by Temperature Conditioning Early in Life. United States Department of Agriculture, 1998. http://dx.doi.org/10.32747/1998.7580676.bard.
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The research on thermotolerance acquisition in broiler chickens by temperature conditioning early in life was focused on the following objectives: a. To determine the optimal timing and temperature for inducing the thermotolerance, conditioning processes and to define its duration during the first week of life in the broiler chick. b. To investigate the response of skeletal muscle tissue and the gastrointestinal tract to thermal conditioning. This objective was added during the research, to understand the mechanisms related to compensatory growth. c. To evaluate the effect of early thermo conditioning on thermoregulation (heat production and heat dissipation) during 3 phases: (1) conditioning, (2) compensatory growth, (3) heat challenge. d. To investigate how induction of improved thermotolerance impacts on metabolic fuel and the hormones regulating growth and metabolism. Recent decades have seen significant development in the genetic selection of the meat-type fowl (i.e., broiler chickens); leading to rapid growth and increased feed efficiency, providing the poultry industry with heavy chickens in relatively short growth periods. Such development necessitates parallel increases in the size of visceral systems such as the cardiovascular and the respiratory ones. However, inferior development of such major systems has led to a relatively low capability to balance energy expenditure under extreme conditions. Thus, acute exposure of chickens to extreme conditions (i.e., heat spells) has resulted in major economic losses. Birds are homeotherms, and as such, they are able to maintain their body temperature within a narrow range. To sustain thermal tolerance and avoid the deleterious consequences of thermal stresses, a direct response is elicited: the rapid thermal shock response - thermal conditioning. This technique of temperature conditioning takes advantage of the immaturity of the temperature regulation mechanism in young chicks during their first week of life. Development of this mechanism involves sympathetic neural activity, integration of thermal infom1ation in the hypothalamus, and buildup of the body-to-brain temperature difference, so that the potential for thermotolerance can be incorporated into the developing thermoregulation mechanisms. Thermal conditioning is a unique management tool, which most likely involves hypothalamic them1oregulatory threshold changes that enable chickens, within certain limits, to cope with acute exposure to unexpected hot spells. Short-tem1 exposure to heat stress during the first week of life (37.5+1°C; 70-80% rh; for 24 h at 3 days of age) resulted in growth retardation followed immediately by compensatory growth" which resulted in complete compensation for the loss of weight gain, so that the conditioned chickens achieved higher body weight than that of the controls at 42 days of age. The compensatory growth was partially explained by its dramatic positive effect on the proliferation of muscle satellite cells which are necessary for further muscle hypertrophy. By its significant effect of the morphology and functioning of the gastrointestinal tract during and after using thermal conditioning. The significant effect of thermal conditioning on the chicken thermoregulation was found to be associated with a reduction in heat production and evaporative heat loss, and with an increase in sensible heat loss. It was further accompanied by changes in hormones regulating growth and metabolism These physiological responses may result from possible alterations in PO/AH gene expression patterns (14-3-3e), suggesting a more efficient mechanism to cope with heat stress. Understanding the physiological mechanisms behind thermal conditioning step us forward to elucidate the molecular mechanism behind the PO/AH response, and response of other major organs. The thermal conditioning technique is used now in many countries including Israel, South Korea, Australia, France" Ecuador, China and some places in the USA. The improvement in growth perfom1ance (50-190 g/chicken) and thermotolerance as a result of postnatal thermal conditioning, may initiate a dramatic improvement in the economy of broiler's production.
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Chejanovsky, Nor, Diana Cox-Foster, Victoria Soroker, and Ron Ophir. Honeybee modulation of infection with the Israeli acute paralysis virus, in asymptomatic, acutely infected and CCD colonies. United States Department of Agriculture, December 2013. http://dx.doi.org/10.32747/2013.7594392.bard.
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Honey bee (Apis mellifera) colony losses pose a severe risk to the food chain. The IAPV (Israeli acute paralysis virus) was correlated with CCD, a particular case of colony collapse. Honey bees severely infected with IAPV show shivering wings that progress to paralysis and subsequent death. Bee viruses, including IAPV, are widely present in honey bee colonies but often there are no pathological symptoms. Infestation of the beehive with Varroa mites or exposure to stress factors leads to significant increase in viral titers and fatal infections. We hypothesized that the honey bee is regulating/controlling IAPV and viral infections in asymptomatic infections and this control is broken through "stress" leading to acute infections and/or CCD. Our aims were: 1. To discover genetic changes in IAPV that may affect tissue tropism in the host, and/or virus infectivity and pathogenicity. 2. To elucidate mechanisms used by the host to regulate/ manage the IAPV-infection in vivo and in vitro. To achieve the above objectives we first studied stress-induced virus activation. Our data indicated that some pesticides, including myclobutanil, chlorothalonil and fluvalinate, result in amplified viral titers when bees are exposed at sub lethal levels by a single feeding. Analysis of the level of immune-related bee genes indicated that CCD-colonies exhibit altered and weaker immune responses than healthy colonies. Given the important role of viral RNA interference (RNAi) in combating viral infections we investigated if CCD-colonies were able to elicit this particular antiviral response. Deep-sequencing analysis of samples from CCD-colonies from US and Israel revealed high frequency of small interfering RNAs (siRNA) perfectly matching IAPV, Kashmir bee virus and Deformed wing virus genomes. Israeli colonies showed high titers of IAPV and a conserved RNAi pattern of targeting the viral genome .Our findings were further supported by analysis of samples from colonies experimentally infected with IAPV. Following for the first time the dynamics of IAPV infection in a group of CCD colonies that we rescued from collapse, we found that IAPV conserves its potential to act as one lethal, infectious factor and that its continuous replication in CCD colonies deeply affects their health and survival. Ours is the first report on the dominant role of IAPV in CCD-colonies outside from the US under natural conditions. We concluded that CCD-colonies do exhibit a regular siRNA response that is specific against predominant viruses associated with colony losses and other immune pathways may account for their weak immune response towards virus infection. Our findings: 1. Reveal that preventive measures should be taken by the beekeepers to avoid insecticide-based stress induction of viral infections as well as to manage CCD colonies as a source of highly infectious viruses such as IAPV. 2. Contribute to identify honey bee mechanisms involved in managing viral infections.
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Halevy, Orna, Zipora Yablonka-Reuveni, and Israel Rozenboim. Enhancement of meat production by monochromatic light stimuli during embryogenesis: effect on muscle development and post-hatch growth. United States Department of Agriculture, June 2004. http://dx.doi.org/10.32747/2004.7586471.bard.
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The original objectives were: A. To determine the critical embryonic age for monochromatic green light stimulation. B. To follow the ontogeny of embryos exposed to monochromatic green light vs. darkness. C. To investigate the effects of monochromatic green light illumination on myoblast and fiber development in the embryo. D. To investigate the stimulatory effect of light combinations during embryo and post-hatch periods on growth and meat production. E. To evaluate the direct effect of monochromatic green light on cultured embryonic and adult myoblasts. The overall purpose of this study was to investigate the effect of monochromatic light stimuli during incubation period of broilers on muscle development and satellite cell myogenesis. Based on previous studies (Halevy et al., 1998; Rozenboim et al., 1999) that demonstrated the positive effects of green-light illumination on body and muscle growth, we hypothesized that monochromatic light illumination accelerates embryo and muscle development and subsequently enhances muscle growth and meat production. Thus, further decreases management costs. Under the cooperation of the laboratories at the Hebrew University of Jerusalem and University of Washington we have conducted the following: 1. We have established the critical stage for exposure to green monochromatic light which has the maximal effect on body and muscle growth (Objective A). We report that embryonic day 5 is optimal for starting illumination. The optimal regime of lighting that will eliminate possible heat effects was evaluated by monitoring egg core temperature at various illumination periods. We found that intermitted lighting (15 min. on; 15 min. off) is optimal to avoid heat effects. 2. We have evaluated in detail gross changes in embryo development profile associated to green light stimuli vs. darkness. In addition, we have investigated the stimulatory effect of light combinations during embryo and post-hatch periods on body and muscle growth (Objective B,D). 3. We have studied the expression profile of muscle regulatory proteins during chicken muscle cell differentiation in cultures using newly developed antibodies. This study paved the way for analyzing the expression of these proteins in our photo stimulation experiments (Objective C). 4. We have studied the pattern ofPax7 expression during myogenesis in the posthatch chicken. Experimental chick pectoralis muscles as well adult myoblast cultures were used in this study and the results led us to propose a novel model for satellite cell differentiation and renewal. 5. The effects of monochromatic green light illumination during embryogenesis have been studied. These studies focused on fetal myoblast and satellite cell proliferation and differentiation at pre- and posthatch periods and on the effects on the expression of muscle regulatory proteins which are involved in these processes. In addition, we have analyzed the effect of photo stimulation in the embryo on myofiber development at early posthatch (Objective C). 6. In follow the reviewers' comments we have not conducted Objective E. The information gathered from these studies is of utmost importance both, for understanding the molecular basis of muscle development in the posthatch chicks and for applied approach for future broiler management. Therefore, the information could be beneficial to agriculture in the short term on the one hand and to future studies on chick muscle development in the embryo and posthatch on the other hand.
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Good Practice Guidance for the Management and Control of Asbestos: Protecting Workplaces and Communities from Asbestos Exposure Risks. Asian Development Bank, March 2022. http://dx.doi.org/10.22617/tim220047-2.
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This publication aims to increase awareness of the health risks associated with asbestos in the workplace and provides recommendations and checklists on avoiding and managing the risks of exposure. Occupational exposure to asbestos is estimated to lead to more than 230,000 deaths globally every year. This publication provides guidance on the duties of employers and contractors in minimizing risks from asbestos; training requirements; and the identification, containment, safe removal, and management of asbestos waste.
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Financial Stability Report - September 2015. Banco de la República, August 2021. http://dx.doi.org/10.32468/rept-estab-fin.sem2.eng-2015.
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From this edition, the Financial Stability Report will have fewer pages with some changes in its structure. The purpose of this change is to present the most relevant facts of the financial system and their implications on the financial stability. This allows displaying the analysis more concisely and clearly, as it will focus on describing the evolution of the variables that have the greatest impact on the performance of the financial system, for estimating then the effect of a possible materialization of these risks on the financial health of the institutions. The changing dynamics of the risks faced by the financial system implies that the content of the Report adopts this new structure; therefore, some analyses and series that were regularly included will not necessarily be in each issue. However, the statistical annex that accompanies the publication of the Report will continue to present the series that were traditionally included, regardless of whether or not they are part of the content of the Report. In this way we expect to contribute in a more comprehensive way to the study and analysis of the stability of the Colombian financial system. Executive Summary During the first half of 2015, the main advanced economies showed a slow recovery on their growth, while emerging economies continued with their slowdown trend. Domestic demand in the United States allowed for stabilization on its average growth for the first half of the year, while other developed economies such as the United Kingdom, the euro zone, and Japan showed a more gradual recovery. On the other hand, the Chinese economy exhibited the lowest growth rate in five years, which has resulted in lower global dynamism. This has led to a fall in prices of the main export goods of some Latin American economies, especially oil, whose price has also responded to a larger global supply. The decrease in the terms of trade of the Latin American economies has had an impact on national income, domestic demand, and growth. This scenario has been reflected in increases in sovereign risk spreads, devaluations of stock indices, and depreciation of the exchange rates of most countries in the region. For Colombia, the fall in oil prices has also led to a decline in the terms of trade, resulting in pressure on the dynamics of national income. Additionally, the lower demand for exports helped to widen the current account deficit. This affected the prospects and economic growth of the country during the first half of 2015. This economic context could have an impact on the payment capacity of debtors and on the valuation of investments, affecting the soundness of the financial system. However, the results of the analysis featured in this edition of the Report show that, facing an adverse scenario, the vulnerability of the financial system in terms of solvency and liquidity is low. The analysis of the current situation of credit institutions (CI) shows that growth of the gross loan portfolio remained relatively stable, as well as the loan portfolio quality indicators, except for microcredit, which showed a decrease in these indicators. Regarding liabilities, traditional sources of funding have lost market share versus non-traditional ones (bonds, money market operations and in the interbank market), but still represent more than 70%. Moreover, the solvency indicator remained relatively stable. As for non-banking financial institutions (NBFI), the slowdown observed during the first six months of 2015 in the real annual growth of the assets total, both in the proprietary and third party position, stands out. The analysis of the main debtors of the financial system shows that indebtedness of the private corporate sector has increased in the last year, mostly driven by an increase in the debt balance with domestic and foreign financial institutions. However, the increase in this latter source of funding has been influenced by the depreciation of the Colombian peso vis-à-vis the US dollar since mid-2014. The financial indicators reflected a favorable behavior with respect to the historical average, except for the profitability indicators; although they were below the average, they have shown improvement in the last year. By economic sector, it is noted that the firms focused on farming, mining and transportation activities recorded the highest levels of risk perception by credit institutions, and the largest increases in default levels with respect to those observed in December 2014. Meanwhile, households have shown an increase in the financial burden, mainly due to growth in the consumer loan portfolio, in which the modalities of credit card, payroll deductible loan, revolving and vehicle loan are those that have reported greater increases in risk indicators. On the side of investments that could be affected by the devaluation in the portfolio of credit institutions and non-banking financial institutions (NBFI), the largest share of public debt securities, variable-yield securities and domestic private debt securities is highlighted. The value of these portfolios fell between February and August 2015, driven by the devaluation in the market of these investments throughout the year. Furthermore, the analysis of the liquidity risk indicator (LRI) shows that all intermediaries showed adequate levels and exhibit a stable behavior. Likewise, the fragility analysis of the financial system associated with the increase in the use of non-traditional funding sources does not evidence a greater exposure to liquidity risk. Stress tests assess the impact of the possible joint materialization of credit and market risks, and reveal that neither the aggregate solvency indicator, nor the liquidity risk indicator (LRI) of the system would be below the established legal limits. The entities that result more individually affected have a low share in the total assets of the credit institutions; therefore, a risk to the financial system as a whole is not observed. José Darío Uribe Governor