Relevant bibliographies by topics / LDL transfer

Academic literature on the topic 'LDL transfer'

Author: Grafiati
Published: 14 March 2023

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Journal articles on the topic "LDL transfer"

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Surya, Ingrid I., Gertie Gorter, and Jan Willem N. Akkerman. "Arachidonate Transfer Between Platelets and Lipoproteins." Thrombosis and Haemostasis 68, no. 06 (1992): 719–26. http://dx.doi.org/10.1055/s-0038-1646350.

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SummaryAlthough platelets have specific bindingsites for LDL and HDL, it is doubtful whether lipoproteins modulate platelet functions via receptor-mediated processes. We investigated platelet-lipoprotein interaction during prolonged incubation with concentrations of LDL and HDL that saturate the bindingsites within a few minutes. When [3H]arachidonate-labeled human platelets were incubated for 4 h with lipoproteins, part of the 3H-radioactivity transferred to LDL and to a lesser extent to HDL. The transfer was temperature-sensitive, unaffected by modification of lysine in LDL or indomethacin treatment of the platelets, and almost irreversible. [3H]arachidonate transfer to lipoproteins could be mimicked by incubating platelets with a high concentration of fatty acid free albumin. This showed, that the loss of 3H-radioactivity reflected a decrease in endogenous arachidonate, leading to impaired aggregation, secretion and thromboxane B2 formation in platelets after stimulation with thrombin but not with arachidonate. Thus, the decrease in platelet functions seen after long incubation with HDL is caused by depletion of platelet arachidonate. Despite an even stronger arachidonate depletion by LDL, this lipoprotein initiated arachidonate metabolism and secretion independent of specific binding sites for LDL on the platelet. Surprisingly, the major part of the secretion was preserved when the formation of prostaglandin endoperoxides/ thromboxane A2 was inhibited with indomethacin. These findings argue against a role for LDL and HDL receptors in the modulation of platelet functions and are more in favor of lipid exchange processes between platelets and lipoproteins.
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YANG, Min, David S. LEAKE, and Catherine A. RICE-EVANS. "Non-oxidative modification of native low-density lipoprotein by oxidized low-density lipoprotein." Biochemical Journal 316, no. 2 (June 1, 1996): 377–80. http://dx.doi.org/10.1042/bj3160377.

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The oxidative modification of low-density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis, although little is known as yet about the precise mechanism of oxidation in vivo. The studies presented here demonstrate that, in the absence of cells or transition metals, oxidized LDL can modify native LDL through co-incubation in vitro such as to increase its net negative charge, in a concentration-dependent manner. The interaction is not inhibited by peroxyl radical scavengers or metal chelators, precluding the possibility that the modification of native LDL by oxidized LDL is through an oxidative process. Studies with radioiodinated oxidized LDL showed no transfer of radioactivity to the native LDL, demonstrating that fragmentation of protein and the transfer of some of the fragments does not account for the modified charge on the native LDL particle. The adjacency of native to oxidized LDL in the arterial wall may be a potential mechanism by which the altered recognition properties of the apolipoprotein B-100 may arise rapidly without oxidation or extensive modification of the native LDL lipid itself.
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Lundberg, B. B., and L. A. Suominen. "Physicochemical transfer of [3H]cholesterol from plasma lipoproteins to cultured human fibroblasts." Biochemical Journal 228, no. 1 (May 15, 1985): 219–25. http://dx.doi.org/10.1042/bj2280219.

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The transfer of free cholesterol from [3H]cholesterol-labelled plasma lipoproteins to cultured human lung fibroblasts was studied in a serum-free medium. The uptake of [3H]cholesterol depended upon time of incubation, concentration of lipoprotein in the medium, and temperature. Modified (reduced and methylated) low-density lipoprotein (LDL), which did not enter the cells by the receptor pathway, gave a somewhat lower transfer rate than unmodified LDL, but if the transfer values for native LDL were corrected for the receptor-mediated uptake of cholesterol the difference was eliminated. The initial rates of transfer of [3H]cholesterol from LDL and high-density lipoprotein (HDL) were of the same order of magnitude (0.67 +/- 0.05 and 0.75 +/- 0.06 nmol of cholesterol/h per mg of cell protein, respectively) while that from very-low-density lipoprotein (VLDL) was much lower (0.23 +/- 0.02 nmol of cholesterol/h per mg) (means +/- S.D., n = 5). The activation energy for transfer of cholesterol from reduced, methylated LDL to fibroblasts was determined to be 57.5 kJ/mol. If albumin was added to the incubation medium the transfer of [3H]cholesterol was enhanced, while that of [14C]dipalmitoyl phosphatidylcholine was decreased compared with the protein-free system. The results demonstrate that, in spite of its low water solubility, free cholesterol can move from lipoproteins to cellular membranes, probably by aqueous diffusion. We propose that physicochemical transfer of free cholesterol may be a significant mechanism for net uptake of the sterol into the artery during atherogenesis.
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Hall, Justin, and Xiayang Qiu. "Structural and biophysical insight into cholesteryl ester-transfer protein." Biochemical Society Transactions 39, no. 4 (July 20, 2011): 1000–1005. http://dx.doi.org/10.1042/bst0391000.

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CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway. In clinical trials, CETP inhibitors increase HDL levels and reduce LDL levels, and therefore may be used as a potential treatment for atherosclerosis. In this review, we cover the analysis of CETP structure and provide insights into CETP-mediated lipid transfer based on a collection of structural and biophysical data.
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Kostner, G. M., F. Krempler, H. Dieplinger, R. Zechner, I. Teubl, and F. Sandhofer. "Altered metabolism of low density lipoprotein in humans after prolonged incubation in plasma." Clinical Science 68, no. 4 (April 1, 1985): 411–18. http://dx.doi.org/10.1042/cs0680411.

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1. Lecithin: cholesterol acyltransferase (LCAT) in combination with exchange and transfer proteins is known to alter the composition of all plasma lipoprotein fractions. 2. Human plasma from healthy donors was incubated for 24 h at 37°C in the absence and at 4°C and at 37°C in the presence of the LCAT inhibitors sodium iodoacetate (5 mmol/l), and the low density lipoprotein fractions (LDL) were isolated. 3. LDL isolated from LCAT-active plasma (LDL-a) exhibited pronounced alterations in their surface material: the relative content of phospholipids and of free cholesterol was reduced and the content of tetramethylurea-soluble apolipoproteins was increased. LDL isolated from plasma incubated at 37°C with or without sodium iodoacetate showed significantly increased triglyceride concentrations. 4. The LDL fractions from LCAT-active and LCAT-inactive (LDL-i) incubates were iodinated with 125I and 131I respectively, and their metabolic behaviour was studied in humans. 5. LDL-a was cleared from circulation at a slower rate as compared with LDL-i (t1/2 = 3.17 ± 0.47 vs 2.88 ± 0.45 days). The apparent fractional catabolic rate of LDL-a, calculated according to a two-pool model, was reduced by 22.2 ± 3.1%. Comparing LDL-a with LDL isolated from LCAT-inactive plasma which had been incubated at 37°C, the changes in the metabolic variables were less pronounced. 6. It is concluded that physiological alterations of the chemical compositions, caused by LCAT and exchange/transfer proteins, influence the metabolism of LDL.
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Murdoch, Susan J., Molly C. Carr, Hal Kennedy, John D. Brunzell, and John J. Albers. "Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution." Journal of Lipid Research 43, no. 8 (August 2002): 1256–63. http://dx.doi.org/10.1194/jlr.m100373-jlr200.

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Phospholipid transfer protein (PLTP), hepatic lipase (HL), and lipoprotein lipase (LPL) have all been reported to be intricately involved in HDL metabolism but the effect of PLTP on the apolipoprotein B-containing lipoproteins relative to that of HL and LPL has not been established. Due to our previous observation of a positive correlation of PLTP activity with plasma apoB and LDL cholesterol, the relationship of PLTP with the LDL subfractions was investigated and compared with that of HL and LPL. Plasma lipoproteins from 50 premenopausal women were fractionated by density gradient ultracentrifugation. Correlations were calculated between the cholesterol concentration of each fraction and plasma PLTP, HL, and LPL activity. Plasma PLTP activity was highly, positively, and selectively correlated with the cholesterol concentration of the buoyant LDL/dense IDL fractions, yet demonstrated a complete absence of an association with the dense LDL fractions. In contrast, HL was positively correlated with the dense LDL fractions but showed no association with buoyant LDL. LPL was also positively correlated with several buoyant LDL fractions; however, the correlations were weaker than those of PLTP. PLTP and LPL were positively correlated and HL was negatively correlated with HDL fractions.The results suggest that PLTP and HL may be important and independent determinants of the LDL subpopulation density distributions.
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Dobner, Petra, and Bernd Engelmann. "Low-density lipoproteins supply phospholipid-bound arachidonic acid for platelet eicosanoid production." American Journal of Physiology-Endocrinology and Metabolism 275, no. 5 (November 1, 1998): E777—E784. http://dx.doi.org/10.1152/ajpendo.1998.275.5.e777.

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After the rapid extracorporal reduction of plasma low-density lipoprotein (LDL) by LDL apheresis, the percentages of arachidonic acid (AA)-containing species of phosphatidylcholine (PC) were lowered in the plasma of patients with hypercholesterolemia. The same PC species with AA were also decreased in the patient’s platelets. Thus the supply of phospholipid-bound AA from LDL to the platelets was probably diminished after the apheresis. We therefore analyzed the concentration dependence of the transfer of phospholipid-bound AA from LDL to the platelets under in vitro conditions. The amount of [14C]AA-PC transferred to platelets strongly increased upon elevation of LDL from 0.1 to 1 mg protein/ml, with a less marked elevation being noted at higher LDL concentrations. After stimulation with thrombin (0.5 U/ml), 7.1% ([14C]AA-PC) and 10.6% ([14C]AA-phosphatidylethanolamine) of the14C transferred from LDL to the platelets were recovered in the eicosanoids [14C]thromboxane B2(TxB2) plus 12-[14C]hydroxyeicosatetraenoic acid. Experimental increases and reductions of the [14C]AA-PC import were associated with comparable modifications in the [14C]TxB2production of the platelets. Accordingly, the import of phospholipid-bound [14C]AA is a necessary prerequisite for the formation of14C-labeled eicosanoids. In summary, the transfer of phospholipids from LDL to the platelets markedly varies within the physiological range of lipoprotein concentrations. LDL contributes to platelet eicosanoid formation by supplying platelets with phospholipid-bound AA.
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Ota, Y., K. Kugiyama, S. Sugiyama, T. Matsumura, T. Terano, and H. Yasue. "Complexes of apoA-1 with phosphatidylcholine suppress dysregulation of arterial tone by oxidized LDL." American Journal of Physiology-Heart and Circulatory Physiology 273, no. 3 (September 1, 1997): H1215—H1222. http://dx.doi.org/10.1152/ajpheart.1997.273.3.h1215.

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The aim of this study was to determine whether apolipoprotein A-1 (apoA-1) may suppress the vasomotor dysregulation by oxidized low-density lipoprotein (ox-LDL), which is known to be an atherogenic lipoprotein. The isolated porcine coronary arterial rings and the cultured endothelial cells from the porcine coronary arteries were exposed to ox-LDL in the presence or absence of complexes of apoA-1 with dimyristoylphosphatidylcholine (DMPC/apoA-1), apoA-1 alone, or DMPC alone. DMPC/apoA-1 but not apoA-1 alone or DMPC alone was found to suppress both impairment of endothelium-dependent arterial relaxation and vasocontraction caused by ox-LDL in the isolated porcine coronary arterial rings suspended in organ chambers. DMPC/apoA-1 absorbed lysophosphatidylcholine (LPC) from ox-LDL and decreased the transfer of LPC from ox-LDL to the surface membrane of the cultured endothelial cells, but apoA-1 alone and DMPC alone had no effect. High-density lipoprotein exerted the protective actions mimicking those observed in DMPC/apoA-1. Thus DMPC/apoA-1 decreased the transfer of LPC from ox-LDL to surface membrane by absorbing LPC, leading to the suppression of ox-LDL-induced dysregulation of endothelium-dependent arterial tone. Therefore, apoA-1 appears to require formation of the complexes with phospholipids to prevent the endothelial dysfunction caused by ox-LDL.
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Fan, Zhenmin, Xiao Liu, Peng Zhang, Jiang Gu, Xia Ye, and Xiaoyan Deng. "Transfer of Low-Density Lipoproteins in Coronary Artery Bifurcation Lesions with Stenosed Side Branch: Numerical Study." Computational and Mathematical Methods in Medicine 2019 (October 15, 2019): 1–10. http://dx.doi.org/10.1155/2019/5297284.

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Evidence from clinical data suggests that the stenotic side branch (SB) is one of the key predictors for SB occlusion-based adverse events. In this study, we hypothesized that coronary bifurcations with stenotic SB might lead to severe concentration polarization of atherogenic lipids, such as the low-density lipoproteins (LDL), motivating the adverse events in the clinic. To confirm this hypothesis, this work numerically investigated the transport of LDL in different bifurcation lesions based on the Medina classification with various location and stenosis severities. The results showed that the coronary bifurcations with stenotic SB might be suffering more serious concentration polarization of LDL on the luminal surface of the SB due to higher level of LDL concentrations. Moreover, compared to the other bifurcation lesion types, the type (1,0,1) had the highest luminal surface LDL concentration along the SB and the highest degree of risk to enhance the process of atherosclerosis. In addition, this study also showed that the luminal surface LDL concentration increased with elevated stenosis severity. The type (1,0,1) with the severe stenosis (75% diameter reduction) had the highest concentration at the SB. In conclusion, these results suggested that both location of lesions and stenosis severities had great influence on the distribution of LDL on the luminal surface of the SB. Therefore, the estimation of disease severity and the interventional therapy should be carried out not only according to the stenosis severities in clinic. Moreover, compared to the other bifurcation lesion types, the type (1,0,1), rather than the type (1,1,1) as usually considered, had the highest luminal surface LDL concentration along the SB and the highest degree of risk to enhance the process of atherosclerosis.
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ENGELMANN, Bernd, Christine KÖGL, Robert KULSCHAR, and Barbara SCHAIPP. "Transfer of phosphatidylcholine, phosphatidylethanolamine and sphingomyelin from low- and high-density lipoprotein to human platelets." Biochemical Journal 315, no. 3 (May 1, 1996): 781–89. http://dx.doi.org/10.1042/bj3150781.

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Following a 1 h incubation of human platelets with low-density lipoprotein (LDL) labelled in the apoprotein fraction (125I-apoB) or in phospholipid fractions [14C-labelled phosphatidylcholine (PC), phosphatidylethanolamine (PE) or sphingomyelin (SM)], the percentage of total 14C associated with the cells was about 3-fold higher than the percentage of 125I. Differences in temperature sensitivity also indicated differential interactions of phospholipids and apoprotein with platelets. In order to assess the amount of [14C]phospholipid transferred from LDL or high-density lipoprotein (HDL) to the cells, the quantity of bound lipoproteins was estimated by adding an excess of unlabelled lipoprotein, or by selectively degrading LDL- and HDL-associated [14C]PC and [14C]PE with phospholipase C. Incubation of platelets with LDL or HDL containing pyrenedecanoic acid-labelled PC or SM (py-PC, py-SM) increased pyrene monomer fluorescence, indicating incorporation of the phospholipids into platelets. With HDL as donor, incorporation of py-SM was greater than uptake of py-PC. Pretreating platelets with elastase dose-dependently inhibited uptake of py-SM and py-PC. Treatment of cells with phospholipase C indicated that the uptake of [14C]PC by platelets, and not the binding of lipoproteins to the cells, was partially inhibited by elastase. In conclusion, LDL and HDL rapidly deliver SM, PC and PE to platelets. Incorporation of LDL-derived phospholipids into platelets is unlikely to be mediated by endocytosis of lipoprotein particles. The uptake of the two choline-containing phospholipids appears to require the presence of specialized platelet membrane protein(s).
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Dissertations / Theses on the topic "LDL transfer"

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Kim, Sungho. "Influence of biomechanical force and mass transfer on the progression of atherosclerosis in human carotid arteries." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41192.

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Atherosclerosis is a vascular degenerative disease leading to progressive thickening in the intima of large and medium sized arteries through the formation of plaque that is very rich with cholesterol. The cholesterol is carried by LDL (low density lipoprotein) particles which pass through the endothelium and accumulate in the intima. The passage of LDL is influenced by wall shear stress which activates physiological responses of the endothelium. However, the causal relationship between the physiological responses and their effect on LDL mass transport is not fully understood. To obtain blood flow patterns in human carotid arteries, a fluid structure interaction (FSI) computational approach is employed, based on the in-vivo arterial geometry constructed from black blood magnetic resonance images (BBMRI) and flow rate boundary conditions obtained from phase contrast images (PC). Wall shear stress (WSS) on the luminal surface is computed, and this variable is related to the formation of leaky junctions, which is a major transendothelial pathway for LDL. A model for the fraction of leaky junction at a surface is incorporated into the overall computational scheme for mass transport, along with pore theory. The theoretical model is applied to images from three human carotid arteries in which the degree of disease ranges from mild to moderate. Maximum mass flux is predicted to be in the downstream region of stenoses where WSS is low, and this result is consistent with the clinical observation of plaque progression downstream of the stenosis. The hypothesis that the majority of LDL enters into the intima through leaky junctions is supported by observation of similar distributions between the pattern of volume flux via leaky junctions and mass flux. These studies suggest that mass flux of LDL can be a predictor to indicate areas with potential for plaque formation and progression in human carotid artery disease.
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Bodily, Courtney Price. "Pragmatic Transfer of Compliment Responses Among Chinese ESL LDS Missionaries." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3713.

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This study investigates the pragmatic transfer Chinese Latter-day Saint (LDS) missionaries speaking English display when responding to compliments in English conversations. Previous studies have shown that native American English speakers have a higher rate of compliment acceptance in their compliment response (CR) strategies. While, native Chinese speakers have a higher rate of denial in their CRs (. A common research question is whether or not CR strategies transfer from a Chinese English speaker's first language (L1) into their English conversations. To measure this, 40 missionaries from the LDS church participated in naturalized role plays. Half were native Chinese (10 male, 10 female), and the other half were native American (10 male and 10 female). Each missionary participated in two role play situations, once with a male researcher and once with a female researcher. These role plays were conducted in English. In each role play the researcher complimented the participant in four areas: 1) ability, 2) native culture/hometown, 3) the LDS church, 4) a small possession (e.g. watch, tie, skirt, etc). CRs were recorded then organized on a CR continuum. A series of univariate and related measures ANOVAs was used to measure significance. Results suggest that Chinese missionaries tend to downgrade and disagree with compliments more than American missionaries. Additionally, female Chinese missionaries tend to overgeneralize using the appreciation token when responding to compliments. Other significant findings include the effect of gender and compliment topic on the missionaries' CR strategies.
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Issa, Hayder Mohammed. "Characterization and improvement of a surface aerator for water treatment." Phd thesis, Toulouse, INPT, 2013. http://oatao.univ-toulouse.fr/10672/1/issa.pdf.

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A new surface aeration system for water and wastewater treatment has been studied. Its uniqueness lies in its ability to operate in two modes: aeration or simply blending (mixing) by just reversing the direction of rotation. An experimental plant has enabled to focus on mass transfer performance and hydrodynamics. The flow pattern and the velocity field measurements inside the agitated tank were performed by both the Laser Doppler Velocimetry (LDV) and the Particle Image Velocimetry (PIV) techniques for the single phase (Mixing) mode and for the two phases (Aeration) mode. The oxygen mass transfer occurs both in the water bulk and in the spray above water surface and has been independently investigated. Different configurations and operational conditions were tested during the experimental part in order to interpret phenomenon effect of the draft tube and RTP propeller, rotational speed, turbine blades submergence and else on the flow field and the oxygen mass transfer in the agitated system that produced mainly by a cone shape turbine. The experimental part dealing with hydrodynamics and flow field shows that the down-pumping operation mode with the draft tube has the most convenient results in the mixing mode with respect to turbulent flow field and mixing time. Whilst for the up-pumping aeration mode the hydrodynamics experimental results show the whole system configuration is the most convenient with regarded to mean velocities, turbulent flow intensity and mixing time. For the oxygen mass transfer experimental part, it is found that the highest standard liquid bulk aeration efficiency is achieved (SAEb = 2.65 kgO2 kw-1h-1) when the whole system configuration is used. The highest standard aeration efficiency at 20°C for the water spray zone is accomplished ((Esp)20 = 51.3 %) with the whole system configuration. Several correlations models have been derived for the oxygen mass transfer in water bulk and spray zones, power consumption and mixing time, on the basis of experimental results. They can be used as tools to estimate these parameters for geometrical and dynamical similar systems at industrial scales.
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Hogue, Jean-Charles. "Contribution de la protéine de transfert des esters de cholestérol à l'hétérogénéité des particules LDL dans l'hypercholestérolémie familiale hétérozygote." Thesis, Université Laval, 2004. http://www.theses.ulaval.ca/2004/21837/21837.pdf.

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Les travaux de maîtrise présentés dans ce mémoire ont permis d’évaluer les propriétés électrophorétiques des particules LDL chez des patients atteints d’hypercholestérolémie familiale hétérozygote et d’identifier certains facteurs impliqués dans les différences observées entre ces patients et des sujets contrôles. L’étude des propriétés électrophorétiques des LDL a permis de déterminer que la principale sous-population de particules LDL était plus petite chez ces patients que chez les sujets contrôles. De plus, nos résultats ont montré que plusieurs facteurs sont impliqués dans l’hétérogénéité des particules LDL, certains d’entre eux étant liés au fait d’être atteint d’hypercholestérolémie familiale, comme la concentration plasmatique de CETP. Ces travaux de maîtrise suggèrent donc qu’une augmentation de la concentration plasmatique de CETP dans l’hypercholestérolémie familiale contribue à l’hétérogénéité des particules LDL chez ces patients et au développement d’un profil lipoprotéinémique athérogène.
The main objective of this study was to examine the relationship between CETP and LDL particle heterogeneity in heterozygous familial hypercholesterolemia. The results of this study suggest that the LDL peak particle diameter was smaller in familial hypercholesterolemia than in controls. Furthermore, the results suggest that several factors are implicated in the LDL particle heterogeneity and that some of them are associated with familial hypercholesterolemia, such as the plasma CETP concentration. This study suggest that increased plasma CETP concentration could lead to significant LDL particle remodeling in familial hypercholesterolemia and could contribute to the pathogenesis of atherosclerosis in these patients.
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PAGES, JEAN-CHRISTOPHE. "Transfert retroviral d'un gene therapeutique pour la correction des deficits hereditaires hepatiques : le recepteur aux ldl et l'hypercholesterolemie familiale." Paris 7, 1996. http://www.theses.fr/1996PA077361.

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La therapie genique peut-elle devenir le traitement electif des deficits hereditaires? ces maladies sont le plus souvent refractaires aux approches medicamenteuses classiques et mettent en jeu le pronostic vital des patients. Le developpement des techniques de biologie moleculaire a permis une meilleure comprehension de leurs mecanismes physiopathologiques. La therapie genique vise a corriger les manifestations phenotypes par l'introduction d'un gene actif dans les cellules deficientes les sujets malades. Les criteres de l'action therapeutique sont : (i) une efficacite mesurable et entrainant une modification du phenotype. (ii) un effet adverse proche de zero ou negligeable au regard du benefice therapeutique. Ceci ne concerne que le patient, les exigences etant plus fortes pour l'environnement. (iii) un mode d'administration peu invasif (voir ii). (iv) un effet prolonge ou reproductible aisement (voir ii). Parmi les organes cible de ce type d'intervention le foie a une place privilegie. L'hepatocyte est le siege d'un grand nombre de voies metaboliques qui sont susceptibles d'etre alterees par l'inactivation d'un des genes codant pour une proteine prenant part a ces fonctions. L'hypercholesterolemie familiale peut etre liee a un deficit fonctionnel du recepteur aux ldl (ldl-r). Ces proteines participent au transport d'une grande part du cholesterol serique. Le foie possede un role cle dans le controle de l'homeostasie lipidique. Les precurseurs des ldl y sont synthetises et le catabolisme du cholesterol qu'ils contiennent ne peut se produire que dans cet organe. Il apparait donc legitime, dans le cadre des deficits en ldl-r, de vouloir retablir une forme active de cette molecule dans les hepatocytes. Nos travaux se placent dans une perspective de transfert retroviral ex vivo de l'adnc du ldl-r humain dans les hepatocytes. Considerant les limites de cette methodologie, nous avons mis en place de nouvelles conditions de transfert. Nottre etude a porte sur : (i) la dependance a l'entree en mitose de la cellule cible pour que les retrovirus puisse s'y integrer. (ii) l'obtention de titres viraux eleves pour maximiser les probabilite d'infection des cellules. Nous avons significativement augmente l'efficacite de transduction des hepatocytes en culture primaire dans differents modeles : murins, simiens et humains. Pour ce faire, nous avons agi a deux niveaux : (i) en modifiant les conditions de culture des hepatocytes. (ii) en augmentant le titre des retrovirus recombinants par stimulation de leur production. Le retentissement clinique de l'hypercholesterolemie familiale pouvant apparaitre tres precocement nous avons entrepris des etudes de therapie cellulaire in utero. La compliance des hepatocytes ftaux, tant sur le plan de la culture que de la cryopreservation, fait de cette approche une alternative attractive. Enfin dans la perspective d'un transfert in vivo du gene therapeutique nous developpons de nouveaux outils : (i) pour ameliorer la receptivite des hepatocytes vis a vis des retrovirus recombinants par stimulation de l'entree en mitose a l'aide d'un facteur de croissance. (ii) pour mettre en uvre une methode d'administration du virus dans laquelle le geste chirurgical est peu invasif. Nous avons ainsi participe a la realisation de conditions qui nous mettraient en phase avec les criteres d'efficacite exposes dans ce paragraphe. Ceci est particulierement important si l'on considere les resultats obtenus lors des premiers essais cliniques. Pour valider notre approche nous avons entrepris une etude preclinique chez le macacus cynomolgus qui nous permettra d'etudier l'expression a long terme du transgene apres reimplantation.
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Reade, Véronique. "Insuffisance renale chronique traitee par hemodialyse : approche du metabolisme des lipoproteines : expression des epitopes de l'apolipoproteine b des ldl, etude de l'interaction des ldl avec differents types cellulaires, etude du transfert des lipides neutres." Lille 2, 1996. http://www.theses.fr/1996LIL2P256.

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Prete, Ana Cristina Lo. "Transferência simultânea de lipídeos de um modelo artificial de lipoproteína (LDE) para a lipoproteína de alta densidade (HDL)." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-23022015-145716/.

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Lipoproteínas do plasma trocam lipídeos e apolipoproteínas constantemente. Além da ação de proteínas de transferência, a habilidade das lipoproteínas em receber ou doar lipídeos depende também de diversos outros fatores. A estrutura e a composição de lipídeos e de proteína das lipoproteínas podem influenciar a fluidez da partícula e, desse modo, esta habilidade da lipoproteína. No plasma, a classe de lipoproteína que é a mais afetada pela transferência de lipídeos é a HDL. O presente estudo foi projetado para estabelecer um método . simples para quantificar a habilidade desta lipoproteína em receber simultaneamente suas principais classes de lipídeos constituintes, fosfolipídeo, colesterol livre, éster de colesterol e triglicerídeo. O método é baseado na troca lipídica ocorrida entre uma nanoemulsão artificial (LDE) que se assemelha à estrutura lipídica da LDL, usada como doador de lipídeos radioativos, e as lipoproteínas plasmáticas. Após precipitação da LDE e das demais lipoproteínas, a capacidade da HDL de receber lipídeos é quantificada pela medida da radioatividade presente na lipoproteína. No presente estudo, foi realizada a padronização deste método, assim como analisadas possíveis interferências no método. No mesmo estudo, foi analisada a transferência de lipídeos da LDE para a partícula de HDL em indivíduos controles. A elevação da temperatura (4 a 37°C), do tempo de incubação (5min a 2h) e de HDL-Colesterol (33 a 244 mg/dL) resultaram em progressivo aumento na transferência dos quatro lipídeos da LDE para a HDL. Por outro lado, o aumento do pH (6,5 a 8,5) e da concentração de albumina (3,50 a 7,00 g/dL) não alteraram os valores de transferência. A amostra de plasma mostrou ser inalterada para este ensaio por período de 12 meses (p>0,05), enquanto que a LDE foi inalterada por até 15 dias (p>0.2). Os resultados da análise intra-ensaio apresentaram imprecisão (C.V.) para · a transferência de fosfolipídeo, colesterol livre, éster de colesterol e triglicerídeo de 0,83, 0,56, 1,49 e 0,51 %, respectivamente. A análise inter-ensaio mostrou imprecisão para os resultados de transferência de fosfolipídeo, colesterol livre, éster de colesterol e triglicerídeo 0,78, 0,59, 1,32 e 0,58%, respectivamente. A média da transferência de fosfolipídeo, colesterol livre, éster de colesterol e triglicerídeo da LDE para a HDL nos 53 voluntários foi de 25,5±2,6, 9,9±1 ,6, 4,8±1,3 e 6,9±1 ,1%, respectivamente. As transferências de éster de colesterol, triglicerídeo e colesterol livre se correlacionaram positivamente entre estes lipídeos. Foram encontradas correlações positivas também entre as transferências de fosfolipídeo e de triglicerídeo e entre a transferência de colesterol livre e a concentração de colesterol de HDL. O método de transferência de lipídeos para a fração HDL mostrou ser prático e preciso, .podendo, dentro das condições ideais estabelecidas neste trabalho, determinar a capacidade receptora de lipídeos da HDL.
Plasma lipoproteins constantly exchange lipids and apolipoproteins. Besides the action of transfer proteins, the ability of lipoproteins to receive or donate lipids also depends on several other factors. The structure, lipid and protein composition of the lipoproteins may influence the fluidity of the particle and thereby this ability of lipoprotein. In the plasma, the lipoprotein class that is the most affected by lipid transfers is HDL. The current study was designed to establish a practical method to quantify the ability of this lipoprotein to simultaneously receive its main constituent lipid classes, namely phospholipid, free cholesterol, cholesteryl ester and triglycerides. The method is based on the lipids exchange between an artificial nanoemulsion (LDE) that resembles the LDL, used as a donor of radioactive lipids, and plasma lipoproteins. After precipitation of the LDE and the others plasma lipoproteins, the accept capacity of the HDL\' is quantified by the measure of radioactivity in the lipoprotein. In the present study, the validation of this method was carried through. Moreover, possible interferences in the method had been analyzed. In the same study, the transfer of lipids of LDE for the particle of HDL from control subjets was analyzed. The rise of temperature (4 to 37°C), time of incubation (5min to 2h) and of HDL-Cholesterol (33 to 244 mg/dL) resulted in gradual increase in the transfer of the four lipids from LDE to HDL. On the other hand, the increase of pH (6.5 to 8.5) and albumin concentration (3.50 to 7.00 g/dL) had not modified the values of transfers. The plasma sample showed to be unchanged for this assay for period of 12 months (p>0.05), whereas the LDE was unchanged for 15-days (p>0.2). The intra-assay results showed imprecision (C.V) of 0.83, 0.56, 1.49 and 0.51 % for phospholipid, free cholesterol, cholesteryl ester and triglycerides transfer, respectively. The inter-assay showed imprecision for results of phospholipid, free cholesterol, cholesteryl ester and triglycerides transfer of 0.78, 0.59, 1.32 and 0.58%, respectively. The average of phospholipid, free cholesterol, cholesteryl ester and triglycerides transfers from LDE to HDL in the 53 volunteers was of 25.5±2.6, 9.9±1.6; 4.8±1 .3 and 6.9±1 .1 %, respectively. Cholesterol ester, triglyceride and free cholesterol transfers positively correlated among each other. A positive correlation was also found between phospholipid and triglyceride transfers and free cholesterol transfer and HDL cholesterol concentration. The method of lipids transfer to HDL showed to be practical and reproducible, being able, inside of the ideal conditions established in this work, to determine the aceptora capacity of lipids of the HDL.
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Viens, Laurence. "Effet des activités de transfert des lipides et d'hydrolyse des triglycérides sur la composition lipidique, la structure et l'oxydabilité des LDL." Dijon, 1996. http://www.theses.fr/1996DIJOMU09.

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Vitillo, Francesco. "Contribution expérimentale et numérique à l’amélioration de l’échange thermique des échangeurs de chaleur compacts à plaques." Thesis, Toulouse, ISAE, 2014. http://www.theses.fr/2014ESAE0039/document.

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Dans le cadre du programme CEA R&D pour développer un prototype industriel de Réacteur à Neutrons Rapides refroidi au Sodium (RNR-Na), cette thèse vise à proposer une technologie d'échangeur de chaleur compact innovant. Afin d'augmenter la compacité globale du composant la conception est réalisée d’un canal: il peut être considéré comme le résultat de la superposition de deux canaux ondulés en opposition de phase. Afin de fournir un modèle numérique physiquement cohérent, un nouveau modèle de turbulence à viscosité turbulente non linéaire nommé modèle ASST a été développé et implémenté dans le solveur ANSYS FLUENT ®. Il a été démontré que le modèle ASST peut fournir une alternative intéressante aux modèles plus complexes. Pour valider le modèle ASST, deux montages expérimentaux ont été réalisés, dont un utilisant la Vélocimétrie Laser à franges et l'autre la Vélocimétrie Laser par images de particules. Pour la validation thermique, l'installation "VHEGAS" a été construite. Une fois le modèle ASST validé, les performances pour différentes géométries peuvent être étudiées. Enfin, il a été montré que la géométrie innovante est la plus compacte parmi les autres technologies d'échangeurs de chaleur compacts type PCHE
In the framework of CEA R&D program to develop an industrial prototype of Sodiumcooled Fast Reactor, the present thesis aimed to propose an innovative compact heat exchanger technology. In order to increase the global compactness the basic idea of this work is to design a channel were the fluid flow is as much three-dimensional as possible. In particular the channel can be thought as the result of the superposition of two undulated channels in phase opposition. To numerically provide a physically-consistent model, a new non-linear eddy viscosity named Anisotropic Shear Stress Transport (ASST) model has been developed and implemented into the available solver ANSYS FLUENT. To validate the numerical model, two experimental sections have been used to acquire an extensive aerodynamic database, whereas, to validate the thermal modeling approach, the VHEGAS facility has been built. Once having validated the ASST model, correlations for friction factor and Nusselt number for various geometries could be obtained. Finally, it has been shown that the innovative channel is the most compact one among the most important existing industrial compact heat exchanger technologies
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Lottin, Hélène. "Proteine de transfert des esters de cholesterol (cetp) et mouvements des lipides neutres entre lipoproteines de haute et basse densite : role des enzymes lipolytiques affectant les hdl." Angers, 1996. http://www.theses.fr/1996ANGE0508.

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Books on the topic "LDL transfer"

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ʻĪsá, Ḥusām. Naql al-tiknūlūzhiyā: Dirāsah fī al-ālīyāt al-qānūnīyah lil-tabaʻīyah al-dawlīyah. Miṣr al-Jadīdah, al-Qāhirah: Dār al-Mustaqbal al-ʻArabī, 1987.

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Al-Mazidi, Salah Mohammed. The analysis of R&D policy and technology transfer in the Gulf Cooperation Council countries: A case study of Kuwait Institute for Scientific Research. Portsmouth: University of Portsmouth, 1999.

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Qānūn al-istimlāk lil-manfaʻah al-ʻāmmah: Qānūn al-Sijil al-ʻAqārī ; qarār inshāʼ al-Hayʼah al-ʻĀmmah lil-arāḍī wa-al-misāḥah wa-al-takhṭīṭ al-ʻumrānī wa-lāʼiḥatuhā al-tanẓīmīyah. [Sana]: al-Jumhūrīyah al-Yamanīyah, Wizārat al-Shūʼun al-Qānūnīyah, 2011.

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al-Maghribīyah, Majallat al-Ḥuqūq. al-Niẓām al-qānūnī al-jadīd lil-ḥuqūq al-ʻaynīyah bi-al-Maghrib fī ḍawʼ al-qānūn raqm 39.08. al-Dār al-Bayḍāʼ: Dār al-Āfāq al-Maghribīyah lil-Nashr wa-al-Tawzīʻ, 2012.

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Yaʻqūb ʻAbd al-Jalīl Muḥammad Rajūb. Jarīmat bayʻ al-arāḍī lil-ʻadūw fī al-tashrīʻ al-jazāʼī al-sārī fī Filasṭīn. al-Quds: Dār al-Jundī lil-Nashr wa-al-Tawzīʻ, 2016.

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al-Taḥwīl al-iliktrūnī lil-amwāl wa-masʼūlīyat al-bunūk al-qānūnīyah. ʻAmmān: Dār al-Thaqāfah lil-Nashr wa-al-Tawzīʻ, 2012.

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Ḥusaynī, Midḥat Muḥammad. Ijrāʼāt al-Shahr al-ʻAqārī: Wafqan lil-taʻdīlāt al-akhīrah. Iskandarīyah: Dār al-Maṭbūʻāt al-Jāmiʻīyah, 1992.

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Daʻāwá waḍʻ wa-shaṭb ishārat al-daʻwá ʻan al-ṣaḥīfah al-ʻaynīyah lil-ʻaqār. Bayrūt: Manshūrāt al-Ḥalabī al-Ḥuqūqīyah, 2010.

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Ṭulbah, Anwar. al-Ṣiyagh al-qānūnīyah lil-ṣuḥuf wa-al-awrāq al-qaḍāʼīyah wa-ṭalabāt al-shahr al-ʻaqārī. Muḥarram Bik [Alexandria]: Dār Nashr al-Thaqāfah, 1986.

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Anil, Malhotra, United Nations. Economic Commission for Western Asia., Unesco, and Markaz Dirāsāt al-Waḥdah al-ʻArabīyah (Beirut, Lebanon), eds. al- Siyāsāt al-tiknūlūjīyah fī al-aqṭār al-ʻArabīyah: Buḥūth wa-munāqashāt al-nadwah al-ʻilmīyah allatī naẓẓamatʹhā al-Lajnah al-Iqtiṣādīyah li-Gharbī Āsiyā al-tābiʻah lil-Umam al-Muttaḥidah bi-al-ishtirāk maʻa Munaẓẓamat al-Umam al-Muttaḥidah lil-Tarbiyah wa-al-ʻUlūm wa-al-Thaqāfah. Bayrūt, Lubnān: Markaz Dirāsāat al-Waḥdah al-ʻArabīyah, 1985.

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Book chapters on the topic "LDL transfer"

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Pages, Jean-Christophe, Marion Andreoletti, Myriam Bennoun, Dominique Franco, Pascale Briand, and Anne Weber. "Retroviral Gene Transfer for LDL Receptor Deficiency into Primary Hepatocytes." In Advances in Experimental Medicine and Biology, 155–59. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4615-1989-8_16.

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Wada, Shigeo, and Takeshi Karino. "Computational Study on LDL Transfer from Flowing Blood to Arterial Walls." In Clinical Application of Computational Mechanics to the Cardiovascular System, 157–73. Tokyo: Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67921-9_16.

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Eisenberg, S. "Non-Genetic Regulation of LDL Metabolism: Role of Lipid Transfer Proteins and Hypertriglyceridemia." In Receptor-Mediated Uptake in the Liver, 74–79. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70956-2_14.

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Kostner, Gerhard M., Gabriele Knipping, Johanna E. M. Groener, Rudolf Zechner, and Hans Dieplinger. "The Role of LCAT and Cholesteryl Ester Transfer Proteins for the HDL and LDL Structure and Metabolism." In Advances in Experimental Medicine and Biology, 79–86. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-1268-0_12.

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Imura, Takehiro. "Feature of P–S, P–P, LCL-LCL, and LCC-LCC." In Wireless Power Transfer, 175–88. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-4580-1_6.

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Bednarczyk, Bartosz, and Jakub Michaliszyn. "“Most of” leads to undecidability: Failure of adding frequencies to LTL." In Lecture Notes in Computer Science, 82–101. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-71995-1_5.

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AbstractLinear Temporal Logic (LTL) interpreted on finite traces is a robust specification framework popular in formal verification. However, despite the high interest in the logic in recent years, the topic of their quantitative extensions is not yet fully explored. The main goal of this work is to study the effect of adding weak forms of percentage constraints (e.g. that most of the positions in the past satisfy a given condition, or that $$\sigma $$ σ is the most-frequent letter occurring in the past) to fragments of LTL. Such extensions could potentially be used for the verification of influence networks or statistical reasoning. Unfortunately, as we prove in the paper, it turns out that percentage extensions of even tiny fragments of LTL have undecidable satisfiability and model-checking problems. Our undecidability proofs not only sharpen most of the undecidability results on logics with arithmetics interpreted on words known from the literature, but also are fairly simple. We also show that the undecidability can be avoided by restricting the allowed usage of the negation, and discuss how the undecidability results transfer to first-order logic on words.
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Snowden, Nick. "Alleviating the LDC Transfer Burden: the Role of Debt Reduction." In External Imbalances and Policy Constraints in the 1990s, 209–36. London: Palgrave Macmillan UK, 1992. http://dx.doi.org/10.1007/978-1-349-22453-1_9.

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Böer, J., H. Fechteler, H. Moryson, F. Sommer, H. Grüneberg, R. Kreutz, D. Krischel, W. Bensiek, and B. Ryan. "Evaluation of Technology Transfer on Collider Quadrupole Manufacture at LBL." In Supercollider 4, 981–84. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3454-9_119.

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Dizaji, Mehrdad Shafiei, and Zhu Mao. "A Hybrid-Attention-LSTM-Based Deep Convolutional Neural Network to Extract Modal Frequencies from Limited Data Using Transfer Learning." In Rotating Machinery, Optical Methods & Scanning LDV Methods, Volume 6, 167–73. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-04098-6_18.

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Ryan, Robert F., and William F. Bensiek. "Interim Report on Technology Transfer on Collider Quadrupole Manufacture at LBL and SSCL." In Supercollider 4, 985–91. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3454-9_120.

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Conference papers on the topic "LDL transfer"

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Iasiello, Marcello, Kambiz Vafai, Assunta Andreozzi, and Nicola Bianco. "THERMODIFFUSION EFFECTS ON LDL DEPOSITION IN A CURVED ARTERY." In ICHMT International Symposium on Advances in Computational Heat Transfer. Connecticut: Begellhouse, 2017. http://dx.doi.org/10.1615/ichmt.2017.220.

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Iasiello, Marcello, Kambiz Vafai, Assunta Andreozzi, and Nicola Bianco. "THERMODIFFUSION EFFECTS ON LDL DEPOSITION IN A CURVED ARTERY." In ICHMT International Symposium on Advances in Computational Heat Transfer. Connecticut: Begellhouse, 2017. http://dx.doi.org/10.1615/ichmt.2017.cht-7.220.

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Kim, Sungho, and Don P. Giddens. "Mass Transfer of LDL Based on Wall Shear Stress From FSI Simulation in Atherosclerotic Human Carotid Artery." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19661.

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Wall shear stress (WSS) distribution and low density lipoprotein (LDL) mass flux are simulated using a fluid-structure interaction (FSI) approach. T2 weighted black blood MRI images of a human left carotid artery are used for the arterial model construction, and the boundary conditions for FSI simulation are derived from phase contrast (PC) MR data. The endothelium is treated as a shear stress dependent, three pathways pore model for LDL particles. The computational results demonstrate that the region distal to an atherosclerotic plaque in the internal carotid artery experiences both low WSS and high mass and volume flux, which are hypothesized to be essential factors in progression of atherosclerosis.
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Masaaki, Hashimoto, and Taguchi Yoshihiro. "MOTION-ROBUST BLOOD PERFUSION SENSING BY LDF WITH FOCUS CONTROL." In International Heat Transfer Conference 16. Connecticut: Begellhouse, 2018. http://dx.doi.org/10.1615/ihtc16.bma.023497.

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Morrow, Thomas B. "Gravimetric Calibration of Critical Flow Venturi Nozzles." In ASME 2004 Heat Transfer/Fluids Engineering Summer Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/ht-fed2004-56817.

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The Metering Research Facility (MRF) was commissioned in 1995/1996 at Southwest Research Institute for research on, and calibration of natural gas flow meters. A key commissioning activity was the calibration of critical flow Venturi (sonic) nozzles by a gravimetric proving process flowing nitrogen or natural gas at different pressures. This paper concerns the calibration of the four sonic nozzles installed in the MRF Low Pressure Loop (LPL). Recently, a new project prompted a review of the relations used to calculate sonic nozzle discharge coefficient in the LPL data acquisition computer code. New calibrations of the LPL sonic nozzles were performed flowing natural gas over a lower range of pressure than used in the original commissioning tests. The combination of new and old gravimetric calibration data are shown to agree well with correlations published by Arnberg and Ishibashi (2001) and by Ishibashi and Takamoto (2001) for laminar, transitional and turbulent boundary layer flow in critical flow Venturi nozzles.
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Umeda, Shinzaburo, and Wen-Jei Yang. "Effects of Mesh-Induced Upstream Turbulence on Flip-Flop Flow Inside Diamond-Shaped Cylinder Bundles." In ASME 2004 Heat Transfer/Fluids Engineering Summer Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/ht-fed2004-56140.

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An experimental study is conducted to investigate effects of mesh-induced upstream turbulence on flip-flop flow inside diamond-shaped cylinder bundles. In order to quantitatively treat flip-flop flow induced by the self-excited oscillation of vortices, flow measurements by means of two-dimensional particle image velocimetry (PIV) and two-dimensional laser Doppler velocimetry (LDV) are employed. Flow cross-sectional area and flow rate are varied to change the Reynolds number in the bundles. A turbulence mesh is installed a very short distance upstream from the inlet of the test section. The LDV is employed to measure velocity changes in the flip-flop flow, while power spectra representing its oscillating characteristics are determined from LDV data. The dominant frequency is observed special features are disclosed in the relationship between the Reynolds number and the Strouhal number representing the dimensionless dominant frequency in all power spectra of the flip-flop flow. It is disclosed that both the flow cross section and the upstream turbulence are related to the generation of flip-flop flow in complex manner, and that the effects of the turbulence differ depending upon the flow cross section.
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Xia, Hongfei, Huanhuan Wu, Yuhua Cheng, and Gaofeng Wang. "A Design Procedure for CPT System with LCL Resonant Network." In 2019 IEEE Wireless Power Transfer Conference (WPTC). IEEE, 2019. http://dx.doi.org/10.1109/wptc45513.2019.9055572.

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Konstantopoulos, Christos, and Thomas Ussmueller. "A Nano-Power Self-Clocked D-LDO for RF Energy Harvesting." In 2021 IEEE Wireless Power Transfer Conference (WPTC). IEEE, 2021. http://dx.doi.org/10.1109/wptc51349.2021.9458127.

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Li, Hongxu, Kui Peng, and Zhifeng Huang. "CALCULATIONS OF DIRECTIONAL RADIATIVE INTENSITY IN ONE-DIMENSIONAL GASEOUS MEDIA USING LBL AND SNB MODELS." In International Heat Transfer Conference 16. Connecticut: Begellhouse, 2018. http://dx.doi.org/10.1615/ihtc16.rti.023162.

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Wen, Huiwen, Ziwei Liang, and Jianqiang Wang. "Effects of coil parameters on transfer efficiency in LCL wireless power transfer system." In 2017 IEEE PELS Workshop on Emerging Technologies: Wireless Power Transfer (WoW). IEEE, 2017. http://dx.doi.org/10.1109/wow.2017.7959409.

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Reports on the topic "LDL transfer"

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OJI, LAWRENCE, and SAVIDRA LUCATERO. CHARACTERIZATION OF INFREQUENT SAMPLES FROM THE CONCENTRATION, STORAGE, AND TRANSFER FACILITY: LEAK DETECTION BOX (LDB) DRAIN CELL SAMPLE LIMS# 20195. Office of Scientific and Technical Information (OSTI), November 2020. http://dx.doi.org/10.2172/1734664.

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DEKARSKE, JOHN. CHARACTERIZATION OF INFREQUENT SAMPLES FROM THE CONCENTRATION, STORAGE, AND TRANSFER FACILITY: LEAK DETECTION BOX (LDB) DRAIN CELL SAMPLE: AUGUST 04, 2022SAMPLE. Office of Scientific and Technical Information (OSTI), September 2022. http://dx.doi.org/10.2172/1889236.

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DEKARSKE, JOHN, and LAWRENCE OJI. CHARACTERIZATION OF INFREQUENT SAMPLES FROM THE CONCENTRATION, STORAGE, AND TRANSFER FACILITY: LEAK DETECTION BOX (LDB) DRAIN CELL SAMPLE: FEBRUARY 09, 2022 SAMPLE. Office of Scientific and Technical Information (OSTI), March 2022. http://dx.doi.org/10.2172/1860323.

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