Relevant bibliographies by topics / LDL

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'LDL'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 May 2024

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'LDL.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "LDL"

1

Wang, Feng, Wei Wang, Kristiina Wähälä, Herman Adlercreutz, Elina Ikonen, and Matti J. Tikkanen. "Role of lysosomal acid lipase in the intracellular metabolism of LDL-transported dehydroepiandrosterone-fatty acyl esters." American Journal of Physiology-Endocrinology and Metabolism 295, no. 6 (December 2008): E1455—E1461. http://dx.doi.org/10.1152/ajpendo.90527.2008.

Full text
Abstract:
Dehydroepiandrosterone-fatty acyl esters (DHEA-FAE) belong to a unique family of naturally occurring hydrophobic steroid hormone derivatives that are transported in circulating lipoproteins and may act as a source of dehydroepiendrosterone (DHEA) and other biologically active steroid hormones in cells. Here, we studied the metabolic fate of low-density lipoprotein-associated [3H]DHEA-FAE ([3H]DHEA-FAE-LDL) and the possible role of lysosomal acid lipase (LAL) in the hydrolysis of DHEA-FAE in cultured human cells. When HeLa cells were incubated with [3H]DHEA-FAE-LDL, the accumulation of label in the cellular fraction increased with incubation time and could be inhibited by excess unlabeled LDL, suggesting LDL receptor or LDL receptor-related receptor-dependent uptake. During 48 h of chase, decreasing amounts of [3H]DHEA-FAE were found in the cellular fraction, while in the medium increasing amounts of unesterified [3H]DHEA and its two metabolites, [3H]-5α-androstanedione (5α-adione) and [3H]androstenedione (4-adione), appeared. As LDL-cholesteryl ester hydrolysis is dependent on LAL activity, we depleted LAL from HeLa cells using small interfering RNAs and compared the hydrolysis of [3H]DHEA-FAE-LDL and [3H]cholesteryl-FAE-LDL. The results demonstrated a more modest but significant reducing effect on the hydrolysis of [3H]DHEA-FAE compared with [3H]cholesteryl-FAE. Moreover, experiments in LAL-deficient human fibroblasts (Wolman disease patient cells) showed that [3H]DHEA-FAE hydrolysis was not completely dependent on LAL activity. In summary, LDL-transported [3H]DHEA-FAE entered cells via LDL receptor or LDL receptor-related receptor-mediated uptake, followed by intracellular hydrolysis and further metabolism into 5α-adione and 4-adione that were excreted from cells. Although LAL contributed to the deesterification of DHEA-FAE, it was not solely responsible for the hydrolysis.
APA, Harvard, Vancouver, ISO, and other styles
2

Vinagre, Carmen G. C., Elisabeth S. Ficker, Claudia Finazzo, Maria J. N. Alves, Katia de Angelis, Maria Claudia Irigoyen, Carlos E. Negrão, and Raul C. Maranhão. "Enhanced removal from the plasma of LDL-like nanoemulsion cholesteryl ester in trained men compared with sedentary healthy men." Journal of Applied Physiology 103, no. 4 (October 2007): 1166–71. http://dx.doi.org/10.1152/japplphysiol.01176.2006.

Full text
Abstract:
The objective of this study was to evaluate the effects of exercise training on plasma removal of a cholesterol-rich nanoemulsion (LDE) that mimics low-density lipoprotein (LDL) lipid structure and binds to LDL receptors. LDE-derived cholesteryl ester plasma kinetics was studied in 24 exercise-trained and 20 sedentary male subjects. LDE labeled with [14C]cholesteryl ester was injected intravenously, and plasma samples were collected over a 24-h period to determine radioisotope decay curves. LDL cholesterol concentration was similar in both groups. Fractional clearance rate (FCR) of the nanoemulsion label was greater in the exercise-trained group compared with the sedentary group (0.138 ± 0.152 and 0.0261 ± 0.023 h−1, respectively). A positive correlation was found ( r = 0.60, P < 0.01) between FCR and peak O2consumption in trained subjects. Circulating oxidized LDL levels were lower in trained subjects compared with the sedentary group (9.0 ± 2.0 and 16.0 ± 3.0 mU/l). LDE was also injected into control and LDL receptor gene knockout mice submitted and not submitted to training. Muscle LDE uptake percentage was increased in the trained mice compared with the untrained mice (1.1 ± 0.8 and 0.2 ± 0.1, respectively, P < 0.0001) in the control group but not in the knockout animals, indicating that the LDL receptor is involved in the increased uptake elicited by exercise. These results show that exercise training increases LDE plasma removal, which in turn suggests that it also increases LDL receptors or LDL receptor activity.
APA, Harvard, Vancouver, ISO, and other styles
3

Oravec, Stanislav, K. Gruber, Elisabeth Dostal, and J. Mikl. "LDL ist nicht gleich LDL." Wiener klinisches Magazin 15, no. 3 (June 2012): 32–34. http://dx.doi.org/10.1007/s00740-012-0005-3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Ebert, James Ray, Miryoung Lee, and Stefan Czerwinski. "LDL-c, LDL-p, and Oxidized-LDL in Overweight Children." Journal of Clinical Lipidology 5, no. 3 (May 2011): 223. http://dx.doi.org/10.1016/j.jacl.2011.03.048.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Levy, Debora, Adriana Aguiar Debes, Andrea Turbuck Celestino, Shirley Schreier, Raul Maranhão, and Sergio Paulo Bydlowski. "Lipid Emulsion as Antisense Oligonucleotides Vector That Inhibits P-Glycoprotein Expression in a Sarcoma Cell Line through LDL Receptor." Blood 112, no. 11 (November 16, 2008): 4633. http://dx.doi.org/10.1182/blood.v112.11.4633.4633.

Full text
Abstract:
Abstract It is well known that antisense oligonucleotides (OAS) are able to inhibit gene expression in a sequence-specific way. The potencial use of an artificial lipid nanoemulsion (LDE) as a vector to carry OAS has been described. LDE was shown to bind 3’-cholesteryl- OAS (C-OAS) and to be internalized into cells through LDL receptors. Here we further explore these findings by examining the capacity of this complex to inhibit MDR-1 gene expression in a sarcoma cell line (MES-DX), which express P-glycoprotein. LDE was prepared as described (Bydlowski et al. ,1995). The capacity of LDE to bind C-OAS was examined by fluorescence spectra analysis using a Hitachi F4500 fluorimeter. Human plasma was obtained from healthy blood donors and LDL, HDL and lipoprotein free serum (LPDS) were separated by sequencial ultracentrifugation. C-OAS/LDE complex was incubated with HDL (apoE donor) before cell experiments were performed. Binding of [3H] LDE/C-OAS complex to LDL receptors from MES-DX cells was studied by competition assay. Two different C-OASs, both complementary to regions flanking the AUG initiation codon were used. Inhibition of MDR-1 gene expression was evaluated by RT-PCR. The binding constant for C-OAS/LDE was 4,2 × 10−3M−1 indicating a high specific capacitiy of conjugation.The C-OAS/LDE complex was shown, by the competition assays and confocal microscopy, to bind to LDL receptors and then to be internalized into cells. Both C-OAS/ LDE complexes strongly inhibited (70% inhibition) the MDR-1 gene expression after 48 hours of cell incubation. This inhibition was not observed when LDE was used alone or complexed with scrambled OAS sequences. The results show that this nanoemulsion binds to cholesteryl-OASs. Moreover, this nanoparticle is an efficient carrier for OAS to target cells expressing LDL receptors. This complex is able to internalize oligonucleotides into cells specifically through the LDL receptor-mediated pathway. The internalized ODN was able to act on nucleic acid sequences as determined by the inhibition of MDR-1 gene expression. Therefore, LDE/C-OAS is promissing nanoparticle complex to be used in gene therapy studies.
APA, Harvard, Vancouver, ISO, and other styles
6

Huygen, Lisa P. M., Jan Westerink, Gerben C. Mol, and Remy H. H. Bemelmans. "When LDL Cholesterol Is Not LDL Cholesterol." JACC: Case Reports 4, no. 11 (June 2022): 690–93. http://dx.doi.org/10.1016/j.jaccas.2022.03.009.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Yeang, Calvin, Joseph L. Witztum, and Sotirios Tsimikas. "‘LDL-C’ = LDL-C + Lp(a)-C." Current Opinion in Lipidology 26, no. 3 (June 2015): 169–78. http://dx.doi.org/10.1097/mol.0000000000000171.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Superko, H. Robert. "CHOLESTEROL METABOLISM, LDL, AND THE LDL RECEPTOR." Chest 100, no. 5 (November 1991): 21. http://dx.doi.org/10.1016/s0012-3692(16)33652-2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Vella, F. "Cholesterol Metabolism, LDL, and the LDL Receptor." Biochemical Education 19, no. 1 (January 1991): 44. http://dx.doi.org/10.1016/0307-4412(91)90161-z.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Scriver, Charles R. "Cholesterol metabolism, LDL and the LDL receptor." Cell 64, no. 3 (February 1991): 485–86. http://dx.doi.org/10.1016/0092-8674(91)90230-v.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "LDL"

1

Liu, Ming-Lin. "LDL oxidation and LDL particle size in the development of atherosclerosis." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/liu/.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Matyas, Angela. "The Functional Characterization of PCSK9's Binding Interactions with LDL and the LDL Receptor." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40592.

Full text
Abstract:
Elevated plasma cholesterol is a risk factor for cardiovascular disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) hinders the uptake of low-density lipoprotein cholesterol (LDL-c) by mediating degradation of LDL receptors (LDLRs) in the liver. Gain-of-function (GOF) mutations in PCSK9 cause familial hypercholesterolemia (FH). In normolipidemic human plasma, 30-40% of PCSK9 is bound to LDL particles, and this association with LDL inhibits PCSK9’s ability to mediate LDLR degradation in cultured cells. To further investigate the physiological relevance of this interaction, we analyzed natural GOF mutations in PCSK9 and assessed their effects in vitro on LDL binding, LDLR binding and LDLR degradation. Our results indicate that several GOF mutations severely inhibit LDL binding compared to wild type (WT) PCSK9, and only modestly affect LDLR affinity and LDLR degradation. These findings shed light on the potential physiological relevance of the PCSK9-LDL interaction, which may have an inhibitory effect on PCSK9 activity in vivo.
APA, Harvard, Vancouver, ISO, and other styles
3

Meilhac, Olivier. "Ldl oxydees et atherosclerose. Mecanismes d'oxydation des ldl, effets de bcl-2 et des antioxydants sur la cytotoxicite des ldl oxydees." Toulouse 3, 1998. http://www.theses.fr/1998TOU30124.

Full text
Abstract:
Les lipoproteines de basse densite oxydees (ldlox) sont fortement impliquees dans l'atherosclerose (une des premieres causes de mortalite dans les pays industrialises). Elles participent a la formation de stries graisseuses, et a l'evolution des lesions vers des stades irreversibles de la maladie. Les ldl, en s'oxydant au cours de leur passage dans l'espace sous-endothelial, presentent de nombreuses proprietes et deviennent notamment cytotoxiques envers differents types cellulaires de la paroi vasculaire. Dans ce travail, nous nous sommes interesses aux mecanismes d'oxydation des ldl et de cytotoxicite des ldlox. Nous rapportons que les mitochondries et la production d'ion superoxyde sont impliquees dans l'oxydation des ldl par les cellules endotheliales humaines (ceh) en culture. L'utilisation d'inhibiteurs de la chaine respiratoire mitochondriale, d'agents decouplants, et la destruction selective des mitochondries par photosensibilisation (sans alteration de la viabilite cellulaire) induisent une diminution de production d'ion superoxyde et inhibent l'oxydation des ldl (arterioscler. Thromb. Vasc. Biol. , 1997, 17 : 1575-1582). Dans la deuxieme partie de notre travail, nous avons mis en evidence une cytotoxicite des ldlox se traduisant par une apoptose massive des ceh, impliquant des voies dependantes de calcium, et inhibee par des acides phenoliques d'origine alimentaire (arterioscler. Thromb. Vasc. Biol. , 1997, 17 : 331-339 et br. J. Pharmacol. , 1998, 123 : 565-573). De plus, les ldlox induisent une augmentation des hydroperoxydes intracellulaires, pouvant participer a la toxicite des ldlox et qui peut etre bloquee par des antioxydants. Enfin, une forte expression de bcl-2 (proteine anti-apoptotique) protege de l'apoptose mais pas de la cytotoxicite des ldlox envers des cellules promyelocytaires et des lymphocytes sanguins humains, suggerant un role proinflammatoire (via la necrose) de cette proteine dans l'atherosclerose.
APA, Harvard, Vancouver, ISO, and other styles
4

Yuahasi, Katia Kioko. "Mecanismos de formação da LDL eletronegativa (LDL-): efeito da glicoxidação e da lipólise." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-09122016-143030/.

Full text
Abstract:
A fração plasmática da lipoproteína de baixa densidade (LDL) é formada por partículas de diferentes tamanhos, carga e densidade. Baseada na diferença de carga das partículas, a LDL pode ser subfracionada em LDL nativa (nLDL) e LDL eletronegativa (LDL‾). A LDL‾ está presente no plasma e possui propriedades aterogênicas e pró-inflamatórias, assim como, possui menor concentração de antioxidantes lipossolúveis, maior concentração de dienos conjugados, alterações conformacionais da apoliproteína B-100 e menor afinidade para o receptor da LDL em comparação com a nLDL. Concentrações elevadas de LDL‾ têm sido observadas em pacientes com alto risco para o desenvolvimento de doenças cardiovasculares, incluindo hipercolesterolemia familiar, diabetes. Considerando-se que os mecanismos envolvidos na formação endógena da LDL‾ ainda não estão elucidados, neste estudo foi investigado o efeito da glicoxidação e da lipólise sobre a partícula LDL para avaliar a contribuição destes processos para a formação da LDL‾ in vitro e in vivo. As modificações químicas da LDL e da imunorreatividade com anticorpo monoclonal anti-LDL‾ foi analisada antes e depois da incubação do plasma com lipoproteína lipase (LPL) ou fosfolipase A2 (PLA2), assim como mimetizando-se a lipólise intravascular. Além disso, na lipólise in vivo foi monitorado no periodo pós-prandial em indivíduos normolipidêmicos para investigar a LDL‾ formada endogenamente. A contribuição da glicoxidação para a geração de LDL‾ foi avaliada in vitro pela incubação da LDL com glicose. O efeito da glicoxidação endógena foi monitorada pela medida, ex-vivo, dos os produtos de glicação avançada (AGEs) e LDL‾ no plasma de pacientes diabéticos tipo I (DM I), tipo II (DM II) e indivíduos intolerantes à glicose (IGT). O processo de glicação não enzimática, in vitro, resultou no aumento da concentração de LDL‾. Os indivíduos dos grupos DM I, DM II e IGT apresentaram concentrações plasmáticas elevadas de LDL‾ em relação aos seus respectivos controles, enquanto observou-se aumento de AGEs apenas nos grupos DM I e DM II. O processo de lipólise in vitro mediado pela LPL e PLA2, induziu aumento significante da concentração de LDL‾; entretanto, somente pela ação da LPL foi associada com modificações oxidativas. Em concordância, o processo de lipólise in vivo (pós-prandial) também promoveu aumento significativo da concentração de LDL‾ associado com modificações oxidativas. Conclusão, nossos dados mostram que, glicoxidação e de lipólise, poderiam contribuir na formação da LDL‾ in vivo.
The low density lipoprotein (LDL) fraction in blood plasma is formed by particles with different size, charge and density. Based on particle charge differences, LDL fraction may be separated into native (nLDL) and electronegative (LDL‾) subfractions. LDL‾ is present in blood plasma and has atherogenic and proinflammatory properties, as well as, lower concentrations of lipid soluble antioxidants, higher content of conjugated dienes, conformational alterations of apolipoprotein B-100 and lower affinity by LDL receptor in comparison to nLDL. Increased LDL‾ concentrations have been found in subjects with high risk for cardiovascular diseases, including those with familiar hypercholesterolemia, diabetes and hyperlipidemia. Considering that the mechanisms involved in the endogenous generation of LDL‾ are not yet well elucidated, in this study the effect of glucoxidation and lipolysis of LDL particles was investigated in order to evaluate their contribution to in vitro e in vivo LDL‾ formation. LDL chemical modifications and its reactivity towards a monoclonal anti-LDL‾ antibody were analyzed before and after incubation of either plasma or LDL with lipoprotein lipase (LPL) or phospholipase A2 (PLA2) as an in vitro lipolysis biomimetic system. Moreover, in vivo lipolysis was monitored at the post-prandial period in normolipidemic subjects to investigate LDL‾ endogenously formed. The contribution of glucoxidation to LDL‾ generation was evaluated in vitro by incubating LDL with glucose. The effect of endogenous glucoxidation was monitored by ex-vivo measurement of advanced glycation end products (AGES) and LDL‾ in blood plasma of type I (DM I) and II (DM II) diabetic patients, as well as, in subjects with glucose intolerance (IGT). The in vitro non-enzymatic glycation resulted in increased LDL‾ formation. The DM I, DM II and IGT groups showed higher LDL‾ concentrations than the respective control groups, while AGEs were increased only in DM I e DM II groups. The in vitro lipolysis mediated by LPL and PLA2 induced a significant increase of LDL‾; however, only LPL action was also associated to LDL oxidative modification. In accordance, in vivo lipolysis (post-prandial) also promoted a significant increase of LDL‾ levels associated to LDL oxidative modification. In conclusion, our data show that both, glycoxidation and lipolysis, could contribute to in vivo LDL‾generation.
APA, Harvard, Vancouver, ISO, and other styles
5

Teixeira, Luciane dos Santos. "Estudos das propriedades ópticas dos complexos európio tetraciclinas e suas aplicações na detecção de lipoproteínas." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-12082011-133857/.

Full text
Abstract:
Este trabalho apresenta as propriedades ópticas dos complexos Európio Tetraciclinas (EuTcs) na presença de LDL e de LDL oxidada com potenciais aplicações em análises clínicas. Foram escolhidos quatro elementos da família das Tetraciclinas: Tetraciclina (Tc), Clorotetraciclina (CTc), Metatetraciclina (MTc) e Oxitetraciclina (OTc) para fazerem parte dos complexos com o íon európio. As melhores condições para se formar os complexos eficientemente foram determinadas, através das medidas dos parâmetros ópticos como: absorção, emissão e de tempo de vida. As melhores concentrações de európio nos complexos EuTcs e possíveis influências de íons inorgânicos normalmente presentes no plasma sanguíneo também foram analisadas. As amostras foram preparadas em pH neutro e a luminescência visível do lantanídeo foi detectada após tempo de repouso das amostras de 15 minutos. Os resultados deste trabalho mostraram que as moléculas de LDL e de LDL oxidada apresentaram um importante papel no aumento da intensidade de emissão dos complexos das Tcs. As medidas realizadas com os complexos EuTcs não apresentaram deslocamentos nos comprimentos de onda dos espectros de absorção e de emissão na presença de LDL, o que demonstra a ausência de interação direta entre as moléculas de Tcs e as moléculas de LDL e LDL oxidada. No entanto, o íon európio pode interagir em diferentes sítios das moléculas de tetraciclinas o que diferenciou a intensidade de emissão de cada complexo. Comparando os resultados obtidos entre os complexos de EuTcs, o complexo EuTc foi o que apresentou perspectivas promissoras na quantificação de LDL e LDL oxidada.
This work presents the optical properties of europium complexes - Tetracyclines (EuTcs) in the presence of LDL and oxidized LDL with potential applications in clinical analysis. Four elements were chosen from the Tetracyclines family: Tetracycline (Tc), Chlortetracycline (CTc), Metatetraciclina (MTc) and Oxytetracycline (OTc) to be part of complexes with europium ion. The best conditions to form the complex efficiently were determined through measurements of optical parameters such as absorption, emission and lifetime. The best concentrations of europium complexes in EuTcs and possible influences of inorganic ions normally present in blood plasma were also analyzed. The samples were prepared at neutral pH and the visible luminescence of lanthanide was detected after resting time of the samples of 15 minutes. These results showed that the molecules of LDL and oxidized LDL have an important role in increase of the emission intensity for Tcs complexes . The measurements performed with the complex EuTcs showed no shifts in the wavelengths of the absorption and emission spectra in the presence of LDL, which demonstrates the absence of direct interaction between the molecules of Tcs and the molecules of LDL and oxidized LDL. However, the europium ion can interact at different sites of the tetracyclines molecules which differed the emission intensity of each complex. Comparing the results obtained between the complexes EuTcs, the complex EuTc is the one that presented the promising prospects in the quantification of LDL and oxidized LDL.
APA, Harvard, Vancouver, ISO, and other styles
6

Höppner, Jens. "Der LDL-Rezeptor und das LDL-Rezeptor-related-Protein als Recyclingrezeptoren für triglyceridreiche Lipoproteine." [S.l.] : [s.n.], 2000. http://www.sub.uni-hamburg.de/disse/169/Disse.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

O'Hagan, C. E. "Physiological catalysts of LDL oxidation." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396887.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Cohen, Danielle. "Lipoproteína de baixa densidade oxidada (LDLox) versus lipoproteína de baixa densidade eletronegativa [LDL(-)] de adolescentes: análise comparativa." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/89/89131/tde-19032014-165411/.

Full text
Abstract:
A obesidade é considerada uma doença crônica e multifatorial, onde eventos como a inflamação de baixa intensidade e as modificações oxidativas estão presentes. A elevada prevalência de obesidade tem impacto direto no desenvolvimento precoce de diabetes mellitus, hipertensão e outros fatores de risco cardiovasculares. Esse perfil tem motivado a identificação de biomarcadores precoces, sendo o monitoramento da lipoproteína de baixa densidade oxidada (LDLox) e lipoproteína de baixa densidade eletronegativa [LDL(-)] potenciais candidatos. Diante do exposto, o objetivo deste estudo foi realizar a análise comparativa e de correlação entre o conteúdo de LDLox e [LDL(-)] em adolescentes. Foram selecionados 137 adolescentes de ambos sexos, com faixa etária de 10 a 19 anos e regularmente em matriculados em escolas públicas da cidade de São Paulo. O peso, altura e circunferência da cintura (CC) foram avaliados. Após jejum (12h-15h) foi coletada uma amostra de sangue e, a partir do plasma, foram realizadas as seguintes análises: glicose, insulina, perfil lipídico, apolipoproteína (AI e B), ácidos graxos não esterificados, tamanho de HDL, atividade da CETP e LDL(-) e LDLox. Os resultados encontrados foram analisados por meio do programa SPSS 15.0, considerando valor de significância de p< 0,05. Os 137 adolescentes foram distribuídos em dois grupos: 71 no Eutrófico (51,82%) e 66 no Obeso (48,18%), segundo a classificação do IMC. 48 (35,04%) dos adolescentes eram do sexo masculino e 89 (64,96%) do sexo feminino, com idade média de 14,2 (2,3) anos. Em relação à CC, observou-se que essa confirmou a classificação feita pelo IMC. Observou-se também uma maior prevalência de hipertensão (65% p = 0,011) e obesidade (64,7% p=0,041) nos antecedentes familiares do grupo Obeso quando comparado ao grupo Eutrófico. Os adolescentes obesos apresentaram maiores valores de triglicerídeos, HDL, APO B, CETP, insulina e LDL(-) e LDLox, quando comparados aos eutróficos. Perfil inverso foi observado para Apo AI. O conteúdo de LDLox e LD(-) variou significativamente em função do IMC. Entretanto, essas partículas de LDLs não se correlacionaram entre si, embora tenham apresentado associação com outros parâmetros cardiometabólicos. Os resultados obtidos confirmam o impacto negativo da obesidade sobre os parâmetros cardiometabólicos de adolescentes e, apesar do conteúdo de LDLox e LDL(-) ter aumentado em função do IMC, essas partículas parecem ser estruturalmente distintas. Essa possibilidade foi reforçada pelas diferentes associações dessas partículas com outros marcadores bioquímicos.
Obesity is considered a chronic and multifactorial disease, where events such as low intensity inflammation and oxidative modifications are present. The high prevalence of obesity has a direct impact on the early development of diabetes mellitus, hypertension and other cardiovascular risk factors. This profile has motivated the identification of early biomarkers, and monitoring the oxidized low density lipoprotein (oxLDL) and electronegative low-density lipoprotein [LDL (-)] are potential markers. The aim of this study was to conduct a comparative analysis and correlation between the content of oxLDL and [LDL (-)] in adolescents. We selected 137 adolescents of both sexes, aged 10-19 years, enrolled in public schools in the city of São Paulo. The weight, height, waist circumference (WC) were assessed. After fasting (12-15h) samples of blood were collected and from plasma were performed the following analyzes: glucose, insulin, lipid profile, apolipoprotein (AI and B), NEFA, HDL size, CETP activity and LDL (-) and oxLDL. The results were analyzed by using SPSS 15.0 considering significant value of p <0.05. The 137 adolescents were divided into two groups: 71 Normal Weight (51.82%) and 66 Obese (48.18%), according to BMI classification. 48 (35.04%) of the adolescents were male and 89 (64.96%) females with a mean age of 14.2 (2.3) years. Regarding the CC observed, it confirmed the classification made by BMI. There was a higher prevalence of hypertension (65% p = 0.011) and obesity (64.7% p = 0.041) in the family history group Obese when compared to normal weight. Obese adolescents had higher triglyceride, HDL, APO B, CETP, insulin and LDL (-) and oxLDL, compared to normal weight. Reverse profile was observed for Apo AI. The content of oxLDL and LDL (-) varied significantly according to BMI. However, these LDL particles were not correlated with each other, although they showed cardiometabolic combination with other parameters. The results confirm the negative impact of obesity on cardiometabolic parameters of teenagers and although the content of oxLDL and LDL (-) increased as a function of BMI, these particles appear to be structurally distinct. This possibility was reinforced by different associations of these particles with other biochemical markers.
APA, Harvard, Vancouver, ISO, and other styles
9

Sarkar, Samantha Khadija. "Asociation of PCSK9 with Low Density Lipoproteins (LDL) in the Regulation of LDL-Cholesterol Levels." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32825.

Full text
Abstract:
Proprotein Convertase Subtilisin / Kexin Type-9 (PCSK9) has emerged as a major regulator of plasma cholesterol levels. PCSK9 is secreted mainly from the liver and circulates as a plasma protein. PCSK9 binds cell surface low-density lipoprotein (LDL) receptors and mediates their degradation upon endocytosis in the liver. This decreases the liver’s ability to clear LDL-cholesterol from the blood. PCSK9 is also capable of binding LDL particles themselves; this interaction inhibits the ability of PCSK9 to bind and mediate LDLR degradation in cultured hepatic cells, but its effect on PCSK9 function in vivo remains unknown. A disordered N-terminal region of the PCSK9 prodomain is necessary for binding to isolated LDL particles in vitro. This N-terminal region is also autoinhibitory to PCSK9-LDL receptor binding. We hypothesized that the N-terminal of the PCSK9 prodomain plays a role in an allosteric mechanism that regulates PCSK9 function. Through mutagenesis studies, we found that both a conserved stretch of acidic residues and an adjacent conserved stretch of hydrophobic residues are crucial for the PCSK9-LDL interaction; the hydrophobicity of the residue at position 38 (Tyr) within the conserved acidic stretch was also found to be important for this. Helical wheel modeling of the prodomain N-terminal sequence revealed the potential for a lipid-ordered amphipathic helix to form, which may aid PCSK9 docking onto LDL. Replacing residues A44 and L41 with helix-disrupting proline residues abolished LDL binding. Co-pelleting ultracentrifugation assays also show that wild-type PCSK9 is capable of associating with liposomes, while the A44P mutation disrupts this lipid association. The A44P-PCSK9 mutation, showing an 80-90% decrease in LDL association but with LDL receptor binding and degrading functions intact, may serve as an important tool in future studies investigating the PCSK9-LDL interaction in vivo. Elucidation of the mechanism by which LDL-binding naturally inhibits PCSK9 activity may also help to develop new anti-PCSK9 therapeutics in the future.
APA, Harvard, Vancouver, ISO, and other styles
10

Hoshikawa, Hajime. "High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1)." Kyoto University, 1999. http://hdl.handle.net/2433/182282.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "LDL"

1

Cholesterol metabolism, LDL, and the LDL receptor. San Diego: Academic Press, 1990.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Moga, Carmen. Low density lipoprotein apheresis for the treatment of familial hypercholesterolemia. Edmonton: Alberta Heritage Foundation for Medical Research, 2004.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Makino, Naoko, and Tamio Teramoto. LDL koresuterōru, chūsei shibō o sageru! reshipi. Tōkyō: Nihon Hōsō Shuppan Kyōkai, 2008.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Dayal, Surendra. LDL online 1998: Computer assisted legal research. Sydney: Butterworths, 1998.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Shalom, Tsur, ed. A logical language for data and knowledge bases. New York: Computer Science Press, 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

S, Pagano Irwin, and Strait Nathan B, eds. HDL and LDL cholesterol physiology and clinical significance. Hauppauge, NY: Nova Science Publishers, 2009.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Modified lipoproteins in the pathogenesis of atherosclerosis. Austin: R.G. Landes Co., 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Naqvi, Shamim. A logical language for data and knowledge bases. New York: Computer Science Press, 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Yang, Chih-Chin. The interaction of bilirubin with human low density lipoprotein (LDL). Ottawa: National Library of Canada, 1995.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Lewińska, Dorota. Możliwoʹsci wykorzystania pektyny jako materiału sorpcyjnego do usuwania LDL-cholesterolu. Warszawa: Instytut Biocybernetyki i Inżynierii Biomedycznej, 2000.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "LDL"

1

Shafi, Hedyeh, Holli M. Mason, and Ellen Klapper. "LDL Apheresis." In Lipid Management, 233–39. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-11161-2_13.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Lackner, K. J., and D. Peetz. "LDL-Rezeptor." In Springer Reference Medizin, 1441. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_3781.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Lackner, K. J., and D. Peetz. "LDL-Rezeptor." In Lexikon der Medizinischen Laboratoriumsdiagnostik, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_3781-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Carlson, Lars A. "LDL apheresis." In Comprehensive lipid testing and management, 123–25. Tarporley: Springer Healthcare Ltd., 2011. http://dx.doi.org/10.1007/978-1-908517-33-3_13.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

van Balen, J. A. M., A. A. Demeulemeester, M. Frölich, K. Mohrmann, L. M. Harms, W. C. H. van Helden, L. J. Mostert, and J. H. M. Souverijn. "LDL-cholesterol." In Memoboek, 151. Houten: Bohn Stafleu van Loghum, 2012. http://dx.doi.org/10.1007/978-90-313-9129-5_85.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Santos, Raul D., Khurram Nasir, and Roger S. Blumenthal. "LDL Targeted Therapies." In Asymptomatic Atherosclerosis, 605–19. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60327-179-0_47.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Keller, Ch. "Extrakorporale LDL-Elimination." In Hyperlipoproteinämie, 53–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-77813-1_6.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Richter, W. O. "Zur LDL-Apherese." In Klinische Anästhesiologie und Intensivtherapie, 201–5. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-78343-2_19.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Orekhov, Alexander N., and Vladimir V. Tertov. "Atherogenic Factors of Blood: Desialylated LDL and Anti-LDL Autoantibodies." In New Aspects of Metabolism and Behaviour of Mesenchymal Cells during the Pathogenesis of Arteriosclerosis, 73–85. Wiesbaden: VS Verlag für Sozialwissenschaften, 1991. http://dx.doi.org/10.1007/978-3-322-99112-6_9.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Wang, Haixun, and Carlo Zaniolo. "Nonmonotonic Reasoning in LDL++." In Logic-Based Artificial Intelligence, 523–44. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-1567-8_22.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "LDL"

1

Görög, P., and V. V. Kakkar. "INCREASED UPTAKE OF MONOCYTE-TREATED LOW-DENSITY LIPOPROTEINS BY AORTIC ENDOTHELIUM IN VIVO." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643356.

Full text
Abstract:
A new technique was elaborated for measuring LDL uptake by rat aortic endothelial cells in vivo, using a fluorescent marker (Dil)-labelled LDL and quantifying the fluorescence in cells selectively removed from the aorta. This technique was used to study the endothelial uptake of LDL modified by activated human monocytes (LDL-A) in comparison with native LDL (LDL-N) protected from oxidation by vitamin E during the preparation. Incubation of LDL with activated monocytes increased endothelial uptake in vivo by 9.3-fold (from 410 ± 99 to 3803 ± 580, ng LDL/106 cells, mean ± s.e.m., p < 0.001) and also by a 4.4-fold (from 613 ± 217 to 2718 ± 605, ng LDL/106 cells, p < 0.01) in cultured confluent porcine endothelium. In contrast, only a 1.5-fold increase (p < 0.05) in uptake of LDL-A was observed in sparse cultures. Cytotoxicity of monocyte-altered or native LDL did not differ as measured by the [3H] deoxyglucose-release test on cultured endothelium. Our results suggest that modification of LDL in the circulation by monocytes may make an important contribution to atherogenesis.
APA, Harvard, Vancouver, ISO, and other styles
2

Reed, Scott M., Min S. Wang, and Erica L. Curello. "Electrophoretic Mobility of Lipid Coated Nanoparticles: Understanding the Influence of Size and Charge on a Lipoprotein Particle Mimic." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-64158.

Full text
Abstract:
Elevated levels of low-density lipoprotein (LDL) are associated with increased risk of coronary heart disease (CHD). Although smaller LDL particles are more atherogenic, it is not clear how LDL particle size influences atherogenesis. Smaller particles may be more prone to macrophage uptake and plaque formation. Alternatively, increased rates of lipid oxidation may explain the atherogenic effects of smaller LDL. We have developed a mimic of LDL that allows independent examination of the effect of LDL size and oxidation. We have engineered LDL mimics using liposome-encapsulated gold nanoparticles, in which the size and surface charge are independently controlled during synthesis. Here we examine the effects of lipid composition on zeta potential and electrophoretic mobility of LDL mimics. Using these mimics, we explored the effect of the lipid coating on the nanoparticles including anionic lipids and oxidized lipids. Dynamic light scattering was used to determine the size of the mimics and gel electrophoresis was used to measure the mobility and calculate zeta potential. The charge of the lipid coating influenced the mobility and we anticipate this will influence how the mimics interacts with proteins.
APA, Harvard, Vancouver, ISO, and other styles
3

Wang, Ke, and Xin Geng. "Binary Coding based Label Distribution Learning." In Twenty-Seventh International Joint Conference on Artificial Intelligence {IJCAI-18}. California: International Joint Conferences on Artificial Intelligence Organization, 2018. http://dx.doi.org/10.24963/ijcai.2018/386.

Full text
Abstract:
Label Distribution Learning (LDL) is a novel learning paradigm in machine learning, which assumes that an instance is labeled by a distribution over all labels, rather than labeled by a logic label or some logic labels. Thus, LDL can model the description degree of all possible labels to an instance. Although many LDL methods have been put forward to deal with different application tasks, most existing methods suffer from the scalability issue. In this paper, a scalable LDL framework named Binary Coding based Label Distribution Learning (BC-LDL) is proposed for large-scale LDL. The proposed framework includes two parts, i.e., binary coding and label distribution generation. In the binary coding part, the learning objective is to generate the optimal binary codes for the instances. We integrate the label distribution information of the instances into a binary coding procedure, leading to high-quality binary codes. In the label distribution generation part, given an instance, the k nearest training instances in the Hamming space are searched and the mean of the label distributions of all the neighboring instances is calculated as the predicted label distribution. Experiments on five benchmark datasets validate the superiority of BC-LDL over several state-of-the-art LDL methods.
APA, Harvard, Vancouver, ISO, and other styles
4

Wang, Ke, and Xin Geng. "Discrete Binary Coding based Label Distribution Learning." In Twenty-Eighth International Joint Conference on Artificial Intelligence {IJCAI-19}. California: International Joint Conferences on Artificial Intelligence Organization, 2019. http://dx.doi.org/10.24963/ijcai.2019/518.

Full text
Abstract:
Label Distribution Learning (LDL) is a general learning paradigm in machine learning, which includes both single-label learning (SLL) and multi-label learning (MLL) as its special cases. Recently, many LDL algorithms have been proposed to handle different application tasks such as facial age estimation, head pose estimation and visual sentiment distributions prediction. However, the training time complexity of most existing LDL algorithms is too high, which makes them unapplicable to large-scale LDL. In this paper, we propose a novel LDL method to address this issue, termed Discrete Binary Coding based Label Distribution Learning (DBC-LDL). Specifically, we design an efficiently discrete coding framework to learn binary codes for instances. Furthermore, both the pair-wise semantic similarities and the original label distributions are integrated into this framework to learn highly discriminative binary codes. In addition, a fast approximate nearest neighbor (ANN) search strategy is utilized to predict label distributions for testing instances. Experimental results on five real-world datasets demonstrate its superior performance over several state-of-the-art LDL methods with the lower time cost.
APA, Harvard, Vancouver, ISO, and other styles
5

Wang, Jing, and Xin Geng. "Learn the Highest Label and Rest Label Description Degrees." In Thirtieth International Joint Conference on Artificial Intelligence {IJCAI-21}. California: International Joint Conferences on Artificial Intelligence Organization, 2021. http://dx.doi.org/10.24963/ijcai.2021/426.

Full text
Abstract:
Although Label Distribution Learning (LDL) has found wide applications in varieties of classification problems, it may face the challenge of objective mismatch -- LDL neglects the optimal label for the sake of learning the whole label distribution, which leads to performance deterioration. To improve classification performance and solve the objective mismatch, we propose a new LDL algorithm called LDL-HR. LDL-HR provides a new perspective of label distribution, \textit{i.e.}, a combination of the \textbf{highest label} and the \textbf{rest label description degrees}. It works as follows. First, we learn the highest label by fitting the degenerated label distribution and large margin. Second, we learn the rest label description degrees to exploit generalization. Theoretical analysis shows the generalization of LDL-HR. Besides, the experimental results on 18 real-world datasets validate the statistical superiority of our method.
APA, Harvard, Vancouver, ISO, and other styles
6

Ren, Tingting, Xiuyi Jia, Weiwei Li, Lei Chen, and Zechao Li. "Label distribution learning with label-specific features." In Twenty-Eighth International Joint Conference on Artificial Intelligence {IJCAI-19}. California: International Joint Conferences on Artificial Intelligence Organization, 2019. http://dx.doi.org/10.24963/ijcai.2019/460.

Full text
Abstract:
Label distribution learning (LDL) is a novel machine learning paradigm to deal with label ambiguity issues by placing more emphasis on how relevant each label is to a particular instance. Many LDL algorithms have been proposed and most of them concentrate on the learning models, while few of them focus on the feature selection problem. All existing LDL models are built on a simple feature space in which all features are shared by all the class labels. However, this kind of traditional data representation strategy tends to select features that are distinguishable for all labels, but ignores label-specific features that are pertinent and discriminative for each class label. In this paper, we propose a novel LDL algorithm by leveraging label-specific features. The common features for all labels and specific features for each label are simultaneously learned to enhance the LDL model. Moreover, we also exploit the label correlations in the proposed LDL model. The experimental results on several real-world data sets validate the effectiveness of our method.
APA, Harvard, Vancouver, ISO, and other styles
7

Beeler, D., L. Fritze, G. Soff, R. Jackman, and R. Rosenberg. "HUMAN THROMBOMODULIN cDNA:SEQUENCE AND TRANSLATED STRUCTURE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643967.

Full text
Abstract:
A 750 bp bovine Thrombomodulin (TM) cDNA fragment was used as an hybridization probe to screen an oligo-dT primed Lambda gtll. cDNA library prepared from human umbilical vein endothelial cell mRNA. A 2.4 kb positive human clone was isolated which showed an 80% nucleotide sequence homology with bovine TM cDNA. This clone and a 550 bp fragment from its 5' end were used to further screen the oligo-dT primed library as well as randomly primed library prepared from the same mRNA. The cDNA clones obtained allow us to describe the overall structure of human TM and reveal that it is extremely similar to the structure of bovine TM, especially as the bovine TM is organized like the receptor for low density lipoprotein (LDL R). Both TM and LDL R exhibit short cytoplasmic C-terminal tails which are either neutral or negatively charged. Other coated pit receptors such as the insulin receptor or the epidermal growth factor (EGF) receptor have very large cytoplasmic regions with a complex tyrosine kinase segment as well as multiple sites for phosphorylation. Both TM and LDL R possess a transmembrane region and an immediately adjacent extracellular serine/threonine rich region which in LDL R has been shown to bear 0-1inked sugars. Both TM and LDL R contain a more distal area of cysteine rich repeats, first noted in the EGF precursor and termed EGF type B. However, the TM EGF type B repeats appear to have been duplicated in TM resulting in their being 6 of them rather than the 3 found in LDL R. The N-terminal half of LDL R is thought to contain the ligand binding region of the receptor and is constructed from multiple cysteine rich repeats similar to those of Complement factor C9. The structure of this region of TM is quite different from that of LDL R, possessing few cysteines. We suspect that protein C and/or thrombin may bind to this unique domain of TM.
APA, Harvard, Vancouver, ISO, and other styles
8

Surya, I. E., and J. W. N. Akkerman. "HUMAN PLASMA PAF-ACETYLHYDROLASE, NORMALLY PRESENT IN LOW DENSITY LIPOPROTEINS, IS ASSOCIATED WITH HIGH DENSITY LIPOPROTEINS IN A PATIENT WITH LDL DEFICIENCY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642882.

Full text
Abstract:
Platelet Activating Factor (l-0-alkyl-2-acetyl-sn-glycerol-3-phosphocholine; PAF) plays an important role in allergic and inflammatory reactions and activates platelets in the nanomolar range. One of the main factors that controls PAF activity in blood is an enzyme that hydrolyzes the acetyl-chain thereby converting PAF to biologically inactive lyso-PAF. The enzyme is acid labile and normally associated with apo B-containing low density lipoproteins (LDL, density 1,006-1,063 g/ml).We investigated whether a deficiency in LDL would affect the enzyme activity. PAF-inactivating activity was measured in plasma from a patient with abetalipoproteinemia, a rare autosomal recessive disorder, characterized by the absence of apo B and apo B-containing lipoproteins (chylomicrons, VLDL and LDL). Plasma triglyceride was 0,2 mmol/1 (normal 1,40-2,20 mmol/1) and cholesterol 1,3 mmol/1 (normal 5,60-7,70 mmol/1). Separation of lipoproteins by density gradient centrifugation revealed a slightly decreased HDL content whereas VLDL and LDL were below the detection limit (0,20 mmol/1; based on cholesterol content).Despite the absence of LDL, PAF-inactivating activity in plasma of the patient (measured by (1) the decrease in aggregation inducing activity of PAF after incubation, (ii) the conversion of 3H-acyl-PAF to lysa PAF, separated on TLC, (iii) the liberation of 3H-label from 3H-acetyl PAF) was present and even slightly higher than in normal plasma (hydrolysis of 3 3H-PAF after 20 minutes incubation was 78 ± 4% and 65 ± 6% in patient and normals, respectively, n = 4). Subfractionation revealed that the enzyme activity was present in fractions with densities of 1,065-1,214 g/ml, which are typical for HDL.These results indicate that PAF-acetylhydrolase, although normally present in LDL, binds to HDL in a patient with extreme LDL-deficiency.Supported by the Dutch Heart Foundation (grant 85082)
APA, Harvard, Vancouver, ISO, and other styles
9

Xu, Miao, and Zhi-Hua Zhou. "Incomplete Label Distribution Learning." In Twenty-Sixth International Joint Conference on Artificial Intelligence. California: International Joint Conferences on Artificial Intelligence Organization, 2017. http://dx.doi.org/10.24963/ijcai.2017/443.

Full text
Abstract:
Label distribution learning (LDL) assumes labels can be associated to an instance to some degree, thus it can learn the relevance of a label to a particular instance. Although LDL has got successful practical applications, one problem with existing LDL methods is that they are designed for data with \emph{complete} supervised information, while in reality, annotation information may be \emph{incomplete}, because assigning each label a real value to indicate its association with a particular instance will result in large cost in labor and time. In this paper, we will solve LDL problem when given \emph{incomplete} supervised information. We propose an objective based on trace norm minimization to exploit the correlation between labels. We develop a proximal gradient descend algorithm and an algorithm based on alternating direction method of multipliers. Experiments validate the effectiveness of our proposal.
APA, Harvard, Vancouver, ISO, and other styles
10

Prabhu, Anmiv S., Alejandro Moraga, Michael Cecchini, Rafael Mulero, Stephen Olsen, Young I. Cho, and Min Jun Kim. "Synthetic Nanoscale Architectures for Lipoprotein Separation." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-66535.

Full text
Abstract:
Current low density lipoprotein (LDL) apheresis procedures are expensive and time consuming. We report here a novel technique to detect and separate nanoparticles using solid state nanopores. Our technique relies on the resistive pulse phenomenon used in coulter counters. We used a 150nm diameter nanopore to detect nanoparticles that closely resembled HDL and LDL in terms of their size and surface charge. Statistical analysis of the translocation data revealed that our setup preferentially allowed the particles resembling HDL to pass thorough while restricting the translocation of the particles that resembled LDL.
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "LDL"

1

Cortés Ortigosa, Francisco, and María Pascual Mora. Characterization of the extraction method of extracellular vesicles by HDL and LDL contamination. Fundación Avanza, May 2023. http://dx.doi.org/10.60096/fundacionavanza/2902022.

Full text
Abstract:
In this study we assess and validate the method of extraction of extracellular vesicles found in blood plasma with commercial kits to exclude potential contamination by plasma HDL and LDL particles using immunoblot analysis.
APA, Harvard, Vancouver, ISO, and other styles
2

Hung, Hsuan-Yu, Hui-Hsiung Lai, Hui-Chuan Lin, and Chung-Yu Chen. Impact of interferon-free antivirus therapy on lipid profiles in patients with chronic hepatitis C: A network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, July 2022. http://dx.doi.org/10.37766/inplasy2022.7.0055.

Full text
Abstract:
Review question / Objective: P: ("Hepatitis C"[Mesh] AND "Hepacivirus"[Mesh] AND "Hepatitis C, Chronic”[Mesh]) I: (direct acting antiviral OR asunaprevir OR boceprevir OR daclatasvir OR dasabuvir OR elbasvir OR glecaprevir OR grazoprevir OR ledipasvir OR ombitasvir OR paritaprevir OR pibrentasvir OR simeprevir OR sofosbuvir OR telaprevir OR velpatasvir OR voxilaprevir) C: placebo O: ( "Cholesterol, VLDL"[Mesh] OR "Cholesterol, LDL"[Mesh] OR "Cholesterol, HDL"[Mesh] OR "Dyslipidemias"[Mesh] OR "lipoprotein cholesterol ester, human" [Supplementary Concept] OR "lipoprotein cholesterol" [Supplementary Concept] ) OR ((lipoprotein cholesterol) OR ("lipidemia") OR (lipid metabolism) OR (lipid)). Information sources: We conducted a comprehensive literature search of PubMed, Cochrane Library, Embase, and Ovid MEDLINE electronic databases from their inception to May 20, 2022.
APA, Harvard, Vancouver, ISO, and other styles
3

Gao, Hui, Chen Gong, Shi-chun Shen, Jia-ying Zhao, Dou-dou Xu, Fang-biao Tao, Yang Wang, and Xiao-chen Fan. A systematic review on the associations between prenatal phthalate exposure and childhood glycolipid metabolism and blood pressure: evidence from epidemiological studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0111.

Full text
Abstract:
Review question / Objective: The present systematic review was performed to obtain a summary of epidemiological evidence on the relationships of in utero exposure to phthalates with childhood glycolipid metabolism and blood pressure. Condition being studied: Childhood cardiovascular risk factors including blood pressure, lipid profile (e.g., triglycerides, total cholesterol, HDL−C, LDL−C) and glucose metabolism (e.g., insulin, insulin resistance, insulin sensitivity, glucose) were the interested outcomes. Eligibility criteria: In brief, epidemiological studies including cohort study, case-control study and cross-sectional survey were screened. Studies regarding relationships between human exposure to organophosphate esters and neurotoxicity were possible eligible for the present systematic review. The adverse neurodevelopmental outcomes included development of cognition, behavior, motor, brain change, emotion, etc. Studies that did not meet the above criteria were not included in this systematic review.
APA, Harvard, Vancouver, ISO, and other styles
4

Kanner, Joseph, Edwin Frankel, Stella Harel, and Bruce German. Grapes, Wines and By-products as Potential Sources of Antioxidants. United States Department of Agriculture, January 1995. http://dx.doi.org/10.32747/1995.7568767.bard.

Full text
Abstract:
Several grape varieties and red wines were found to contain large concentration of phenolic compounds which work as antioxidant in-vitro and in-vivo. Wastes from wine production contain antioxidants in large amounts, between 2-6% on dry material basis. Red wines but also white wines were found to prevent lipid peroxidation of turkey muscle tissues stored at 5oC. The antioxidant reaction of flavonoids found in red wines against lipid peroxidation were found to depend on the structure of the molecule. Red wine flavonoids containing an orthodihydroxy structure around the B ring were found highly active against LDL and membrane lipid peroxidation. The antioxidant activity of red wine polyphenols were also found to be dependent on the catalyzer used. In the presence of H2O2-activated myoglobin, the inhibition efficiency was malvidin 3-glucoside>catechin>malvidin>resveratol. However, in the presence of an iron redox cycle catalyzer, the order of effectiveness was resveratol>malvidin 3-glucoside = malvidin>catechin. Differences in protein binding were found to affect antioxidant activity in inhibiting LDL oxidation. A model protein such as BSA, was investigated on the antioxidant activity of phenolic compounds, grape extracts, and red wines in a lecithin-liposome model system. Ferulic acid followed by malvidin and rutin were the most efficient in inhibiting both lipid and protein oxidation. Catechin, a flavonal found in red-wines in relatively high concentration was found to inhibit myoglobin catalyzed linoleate membrane lipid peroxidation at a relatively very low concentration. This effect was studied by the determination of the by-products generated from linoleate during oxidation. The study showed that hydroperoxides are catalytically broken down, not to an alcohol but most probably to a non-radical adduct. The ability of wine-phenolics to reduce iron and from complexes with metals were also demonstrated. Low concentration of wine phenolics were found to inhibit lipoxygenase type II activity. An attempt to understand the bioavailability in humans of antocyanins from red wine showed that two antocyanins from red wine were found unchanged in human urine. Other antocyanins seems to undergo molecular modification. In hypercholesterolemic hamsters, aortic lipid deposition was significantly less in animals fed diets supplemented with either catechin or vitamin E. The rate of LDL accumulation in the carotid arteries was also significantly lower in the catechin and vitamin E animal groups. These results suggested a novel mechanism by which wine phenolics are associated with decreased risk of coronary heart diseases. This study proves in part our hypothesis that the "French Paradox" could be explained by the action of the antioxidant effects of phenolic compounds found at high concentration in red wines. The results of this study argue that it is in the interest of public health to increase the consumption of dietary plant falvonoids. Our results and these from others, show that the consumption of red wine or plant derived polyphenolics can change the antioxidant tone of animal and human plasma and its isolated components towards oxidative reactions. However, we need more research to better understand bioavailability and the mechanism of how polyphenolics affect health and disease.
APA, Harvard, Vancouver, ISO, and other styles
5

Zhao, Shaoping, Jiao Zhong, Caihong Sun, and Junping Zhang. Effects of Aerobic Exercise on TC, HDL-C, LDL-C and TG in patients with hyperlipidemia : A protocol of Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2021. http://dx.doi.org/10.37766/inplasy2021.2.0037.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Chen, Sijia, Shuangyu Wang, and lishuo Gao. Whether nurse-led telephone follow-up is more effective than usual care in improving blood pressure and LDL cholesterol levels in patients with cardiovascular and cerebrovascular disease. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2024. http://dx.doi.org/10.37766/inplasy2024.3.0054.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Chen, Jiankun, Yingming Gu, Lihong Yin, Minyi He, Na Liu, Yue Lu, Changcai Xie, Jiqiang Li, and Yu Chen. Network meta-analysis of curative efficacy of different acupuncture methods on obesity combined with insulin resistance. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2022. http://dx.doi.org/10.37766/inplasy2022.8.0075.

Full text
Abstract:
Review question / Objective: Population：Patients diagnosed as obesity with insulin resistance. Obesity reference: Consensus of experts on the Prevention and treatment of adult obesity in China in 2011 and Consensus of Chinese experts on medical nutrition therapy for overweight/obesity in 2016 were developed by the Obesity Group of Chinese Society of Endocrinology(CSE); BMI≥28. IR reference: According to the Expert opinions on insulin resistance evaluation published by Chinese Diabetes Society, HOMA-IR≥2.68 is regarded as the standard for the diagnosis of IR. Regardless of age, gender and course of disease. Patients diagnosed as obesity with insulin resistance. Intervention：Any kind of acupuncture, moxibustion, acupuncture+moxibustion, warm acupuncture, electropuncture, auricular point, acupoint application and acupoint catgut embedding. Comparison：Other acupuncture treatments, Drug therapy or blank control. Outcome：Primary outcomes: ①Fasting blood-glucose (FBG); ②Fasting serum insulin (FINS); ③Homeostasis model assessment-IR (HOMA-IR); ④Body Mass Index (BMI). Secondary outcomes: ①Waistline; ②Waist-hip ratio;③Triglyceride (TG); ④Total cholesterol (TC); ⑤High-density lipoprotein (HDL); ⑥Low-density lipoprotein (LDL). Study: Randomized controlled trials (RCTs) of different acupuncture methods in the treatment on obesity with insulin resistance, blind method and language are not limited. Randomized controlled trials (RCTs).
APA, Harvard, Vancouver, ISO, and other styles
8

Andersson, L., P. Doolan, N. Feldman, A. Fredette, and B. Thomas. LDP Specification. RFC Editor, January 2001. http://dx.doi.org/10.17487/rfc3036.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Thomas, B., and E. Gray. LDP Applicability. RFC Editor, January 2001. http://dx.doi.org/10.17487/rfc3037.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Andersson, L., I. Minei, and B. Thomas, eds. LDP Specification. RFC Editor, October 2007. http://dx.doi.org/10.17487/rfc5036.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'LDL' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography