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1

Valovaya, M. D. "CHANGES IN FOREIGN TRADE POLICY MAJOR INTEGRATION ASSOCIATIONS IN CONDITIONS OF TURBULENCE IN THE GLOBAL ECONOMY." International Trade and Trade Policy, no. 2 (July 6, 2018): 37–46. http://dx.doi.org/10.21686/2410-7395-2018-2-37-46.

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Turbulent states, structural changes and systemic crises of the world economy have been one of the decisive factors influencing the activity of large integration associations in all centuries. A particularly clear example is the integration processes in the Eurasian space. «The Great Silk Road» – a huge branched system of caravan routes. The Great Silk Road was a kind of connecting link between countries, civilization and socio-economic systems. The path «From the Varangians to the Greeks functioned along the Volga route. The end of the 17th and the first quarter of the 18th centuries was the period of Peter's reforms. Peter I regarded foreign trade as an important means of integrating Russia into Western European culture. Major bans related to the outside world were imposed on the Russian economy in the early 19th century. Anglo-German rivalry and antagonism played a decisive role in the complex system of imperialist contradictions that led to the First World War in 1914–1918. The Second World War almost six times exceeded the First in terms of the total number of victims: 50 million people. The consequence of the Second World War was the formation of the world socialist system, the disintegration of the colonial system and the beginning of the formation and development of major integration projects in Europe, Latin America, East Asia and Africa. Since January 2015, the Eurasian Economic Union functions. The possibilities of cooperation between the EAEU and other integration associations are widely discussed. The interface with the project of the Economic belt of the Silk Road Road is of particular interest.
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COATSWORTH, JOHN H. "Inequality, Institutions and Economic Growth in Latin America." Journal of Latin American Studies 40, no. 3 (July 17, 2008): 545–69. http://dx.doi.org/10.1017/s0022216x08004689.

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AbstractThis essay examines three recent historical approaches to the political economy of Latin America's relative economic backwardness. All three locate the origins of contemporary underdevelopment in defective colonial institutions linked to inequality. The contrasting view offered here affirms the significance of institutional constraints, but argues that they did not arise from colonial inequalities, but from the adaptation of Iberian practices to the American colonies under conditions of imperial weakness. Colonial inequality varied across the Americas; while it was not correlated with colonial economic performance, it mattered because it determined the extent of elite resistance to institutional modernisation after independence. The onset of economic growth in the mid to late nineteenth century brought economic elites to political power, but excluding majorities as inequality increased restrained the region's twentieth-century growth rates and prevented convergence.
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Žiemelis, Darius. "The comparative analysis of Lithuanian manorial-serf economy and hacienda economic system of Latin America in the context of capitalist world system: from the second half of the 18th to the second half of the 19th centuries." Romanian Journal for Baltic and Nordic Studies 10, no. 2 (December 15, 2018): 27–65. http://dx.doi.org/10.53604/rjbns.v10i2_3.

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The paper compares for the first time in historiography the Lithuanian manorial-serf economy and Latin American hacienda economic systems of the second half of the 18th century to the second half of the 19th century in the context of the capitalist world system (CWS). The main focus will be on the explication in macro level of similarities and differences of structures and development trends of these systems. The analyzed period corresponds to the stage of both the dominance and intensification of manorial-serf economy in Lithuania and predominance and intensification of hacienda economy in Latin American countries and it was determined by the same factor of the industrial revolution. The study confirms the thesis that these economic systems belonged to typologically closed economic kind (they were focused on the serfdom method of production) in the global division of labor. It shows that both Lithuanian manorial-serf economy and haciendas of Latin America were not typical feudal enterprises, but displayed only peripheral (agrarian) capitalism features.
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Falleti, Tulia G. "Theory Production: Made In or For Latin America?" Latin American Politics and Society 56, no. 01 (2014): 23–26. http://dx.doi.org/10.1017/s1531426x00003733.

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The essay by Murillo, Shrank, and Luna constitutes a much-needed and welcome wake-up call for those of us who study Latin America—and for political scientists more generally. The authors make a plea for “a rigorous, comparative, and empirically grounded” study of Latin American political economy. I fully agree with their diagnosis of this field and their recommendations. I also praise the authors for defining political economy broadly—rather than narrowly, through a focus on research methods. They understand political economy to encompass all the economic, social, and political factors that are either contextual conditions or consequences of major macroeconomic transformations. Thus the authors lay out an important research agenda for the study of Latin American political economy that includes not only issues of economic development and inequality, but also patterns of democratic politics, state capacities, the rule of law, identity politics, and international linkages, among others. For the authors, the major political and economic transformations that the region has undergone since the start of the twentyfirst century—in its postneoliberal era—cry out for a contextualized research agenda and, I would add, open a host of opportunities for theoretical and conceptual innovation.
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Buono, R. A. Dello. "Technology and Development in Latin America: Urgent Challenges for the 21st Century." Perspectives on Global Development and Technology 11, no. 3 (2012): 341–51. http://dx.doi.org/10.1163/156914912x651523.

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Abstract Capitalist globalization has accelerated technological development but the result has been to intensify global inequalities and reproduce the structures of underdevelopment in entire world regions. In Latin America, the era of Keynesian developmentalism sought to overcome foreign domination that prevailed in modernization-style development regimes. Advances made in that era were halted and later reversed through the imposition of neoliberalism throughout the region. Neoliberal development increased developing country dependency upon foreign technologies and reproduces the structures of underdevelopment. Anti-neoliberal alternatives are possible even under conditions of severe economic crisis as illustrated by the Cuban socialist model. Other countries will likewise need to pursue more endogenously oriented technology policies if they are to overcome the crippling impact of the neoliberal period.
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6

Kiss, Amarilla. "Maritime Piracy in the Modern Era in Latin America." Acta Hispanica, no. II (October 5, 2020): 121–28. http://dx.doi.org/10.14232/actahisp.2020.0.121-128.

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Maritime piracy is an activity that was considered defunct long ago and that Latin American countries experience it again in the 21st century. Since 2016 the number of attacks has increased dramatically involving armed robbery, kidnapping and massacre. Modern day piracy has nothing to do with the romantic illusion of the pirates of the Caribbean, this phenomenon is associated with the governmental, social or economic crisis of a state. When it appears, we can make further conclusions regarding the general conditions of the society in these states. But do these attacks really constitute piracy under international law? Does Latin American piracy have unique features that are different from piracy in the rest of the world? The study attempts to answer the questions why piracy matters in Latin America and how it relates to drug trafficking and terrorism. Apart from that, the study presents a legal aspect comparing the regulation of international law to domestic law, especially to the national law of Latin American states.
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7

Birn, Anne-Emanuelle. "Child health in Latin America: historiographic perspectives and challenges." História, Ciências, Saúde-Manguinhos 14, no. 3 (September 2007): 677–708. http://dx.doi.org/10.1590/s0104-59702007000300002.

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Patterns of child health and well-being in Latin America's past - have been assumed to be delayed and derivative of European and North Americanexperiences. Through an examination of recent historiography, this essay traces a more complex reality: interest in infant and child health in Latin America arose from a range of domestic and regional prerogatives. This attention was rooted in preColumbian cultures, then relegated to the private sphere during the colonial period, except for young public wards. Starting in the 19th century, professionals, reformers, and policy-makers throughout the region regarded child health as a matter central to building modern societies. Burgeoning initiatives were also linked to international priorities and developments, not through one-way diffusion but via ongoing interaction of ideas and experts. Despite pioneering approaches to children's rights and health in Latin America, commitment to child well-being has remained uneven, constrained in many settings by problematic political and economic conditions uch.
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8

Yakovlev, P. P. "Russia and Latin America: Constants and Variables in Trade and Economic Relations." Outlines of global transformations: politics, economics, law 14, no. 3 (July 3, 2021): 209–26. http://dx.doi.org/10.23932/2542-0240-2021-14-3-12.

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The article shows that during the two decades of the 21st century, a new reality of trade and economic relations between the Russian Federation and Latin America (Latin-Caribbean America – LCA) has been formed and filled with concrete content, which, it can be argued, has passed the test of complementarity, and in a number of cases reached the level of large-scale partnership. According to the author, these relations are not artificially done geoeconomic construction, but a consequence of both objective factors that bring Russia and the LCA closer together (including in approaches to achieving the sustainable development goals and restructuring of the existing system of world economic relations), and the efforts of state bodies, business circles, representatives of the expert community interested in the development of Russian-Latin American cooperation. Of course, over the past decades the dynamics of trade and economic relations between Russia and Latin America has not always been stable, at some point it was largely lost, there was some pullback and “surrender” of some significant positions. This happened in large part because in the conditions of increased turbulence in the international markets and rapid global changes, the parties sometimes lost a promising vision of the future of Russian-Latin American economic cooperation, did not find opportunely new areas of cooperation attractive to both sides. In fact, positive introductory approaches to strengthening relations on the principles of strategic partnership have been periodically tested, especially in times of renewed international instability that has eroded the established world order. But each time the parties mobilized existing internal reserves and offered extraordinary areas of interaction. An example of the most recent time is the Russian vaccine Sputnik V, which has crossed political boundaries on the map of Latin-Caribbean America, became the core of the so called “vaccine diplomacy” and opened a “second breath” in the relationship between Russia and the LСA in the key area of business cooperation.
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Teichman, Judith. "Inequality in Twentieth-Century Latin America: Path Dependence, Countermovements, and Reactive Sequences." Social Science History 43, no. 1 (December 14, 2018): 131–57. http://dx.doi.org/10.1017/ssh.2018.29.

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Most recent explanations of social welfare and development outcomes have focused on the role and impact of formal institutional arrangements, particularly the state. The institutional legacies of colonial rule and the role of democratic institutions have been common explanatory variables. This article focuses on the historical origins, persistence, and increases in inequality in Mexico and Chile during the twentieth century. It argues that despite important historical economic and political institutional differences, similar processes account for the unequal distributional outcomes that characterize the two cases. Critical conjunctures involved bitter struggle between social groups. While popularly based countermovements (along the lines predicted by Karl Polyani) arose periodically and struggled to improve social conditions, these movements were unable to alter the underlying sources of inequality. By mid-twentieth century, popular pressure had been able to exact only an unequal form of embeddedness (or social protection from the market) that contributed to inequality. Further, waves of popular mobilization linked to critical conjunctures produced reactive historical sequences involving fierce resistance from propertied elites and their middle-class allies. This resistance inevitably gave rise to new conjunctures ushering in new institutional arrangements that entrenched or increased inequality. The absence of a distributive settlement between propertied classes and popular groups was at the heart of the mobilization and countermobilization cycles in both cases; indeed, it was the depth of this disagreement, particularly the disagreement over private property, that fueled reactive sequences and their unequalizing outcomes.
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10

Enns, Peter K., and Jose T. Sanchez Gomez. "The Polls—Trends Economic Evaluations and Political Change in Chile, 1966 to 2018." Public Opinion Quarterly 83, no. 3 (2019): 627–39. http://dx.doi.org/10.1093/poq/nfz029.

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Abstract Over the past half century, Chile has fluctuated wildly in terms of economic prosperity and democratic health. Using 78 surveys archived at the Roper Center for Public Opinion Research, we document the evolution of Chileans’ perceptions of their personal, family, and national economic conditions during major political and economic changes. The data show that prior to the Pinochet dictatorship, despite a growing economic crisis, Chileans’ perceptions of their family’s economic situation—particularly among the lower socio-economic class—improved, suggesting that Allende’s social and economic policies may have had their intended effect. In contrast, through the democratic transition and the contemporary period, economic evaluations typically tracked objective economic conditions. We conclude by discussing how these patterns can inform public opinion research in Latin America and beyond.
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11

Andreev, Anton. "Uruguay and the USSR in 1945–1991: bilateral relations in the context of the left movement." Latinskaia Amerika, no. 9 (2022): 54. http://dx.doi.org/10.31857/s0044748x0021677-3.

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In modern international conditions Russia is forced to change the vectors of its foreign policy. Moscow paying attention to the countries of Latin America, seeing them as its political and economic partner. However, Russian-Latin American relations have historical traditions formed during the Cold War. The purpose of this article is to show the development of bilateral relations between the USSR and Uruguay in the second half of the 20th century in the context of the development of the Latin American left movement. Based on archival materials, press, memoirs, the article shows how contacts between the left parties of Uruguay and the CPSU influenced to the formation of relations between the two states. Using diplomatic documents, the author reveals the main stages and events of bilateral relations.
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12

Monteverde, Malena, Alberto Palloni, Montserrat Guillén, and Silvia Tomas. "Early Poverty and Future Life Expectancy with Disability among the Elderly in Argentina." Revista Latinoamericana de Población 14, no. 26 (December 19, 2019): 5–22. http://dx.doi.org/10.31406/relap2020.v14.i1.n26.1.

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Two aspects of the aging process in Latin America should be specially taken into account in order to evaluate future perspectives of morbidity among the elderly in the region: 1) Cohorts who will compose the bulk of the elderly population in the 21st century in Latin America survived to old age largely because of improvements in medicine and to a much lesser extent to amelioration of living standards, as it is the case in high income countries, and 2) a high proportion of the Latin American population still live in poor economic conditions and even these vulnerable individuals continue to experience gains in (adult and older adult) survival. We aim to evaluate to what an extent recent levels of poverty and indigence among young children in Argentina could impact future levels of disability and demands for long-term care of older people. Our results show that given the levels of poverty and indigence in childhood observed between 1988 and 1994, the relationship between poor early conditions, and the risk of being disabled among the elderly in Argentina, life expectancy with disability at age 60 years old would increase substantially between 2000 and 2040, both in absolute and relative terms.
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13

Tayar, Violetta. "EUROPEAN UNION AND LATIN AMERICA : THE MAIN FORMS AND TRENDS OF INTERREGIONAL COOPERATION." Urgent Problems of Europe, no. 3 (2022): 44–66. http://dx.doi.org/10.31249/ape/2022.03.02.

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The article observes the evolution of bi-regional cooperation between the EU and Latin-Caribbean America (LCA). The author pays special attention to the obstacles that impede the interregional interaction in recent years. Some other difficulties and prospects in concluding new bi-regional agreements, including «EU-MERCOSUR» Treaty are analyzed. Also, the dynamics of economic cooperation during the first two decades of the 21 st century are traced. The article focuses on the specific characters of mutual foreign trade during the pandemic period. At the same time the author explores the promising forms of interregional «EU-LCA» interaction in the near future. The article shows that during the pandemic a wide range of interregional communication remained within the framework of common economic interests, among them the cooperation in the healthcare, in solving climate problems, investing in renewable energy sources, in protection of the multilateral trade system and searching synergies between the trade policy and the global Agenda 2030. The inclusion of challenges of sustainable development is the important task for partnership agreements with Mexico, Chile, and MERCOSUR - EU format. The European Union remains its status of a leading investor and the donor in the framework of official development assistance (ODA) programs for LCA countries. The author concludes that the post-pandemic period will be characterized by the certain adjustments in the global economic relations in a short-term perspective, especially in the recovery process from a sharp decline in the macroeconomic indicators on both sides of the Atlantic. Under the new conditions, the fragmentation of regional integration may intensify in the foreseeable future, and the role of the state in national economies may increase. At the same time, in the European and Latin American directions there may be an expansion of humanitarian ties between countries.
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Sette Whitaker Ferreira, João, Eduardo Rojas, Higor Rafael De Souza Carvalho, Carolina Rago Frignani, and Ligia Santi Lupo. "Housing policies and the roles of local governments in Latin America: recent experiences." Environment and Urbanization 32, no. 2 (July 8, 2020): 333–50. http://dx.doi.org/10.1177/0956247820935699.

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In the last few decades, most Latin American countries have made good progress in improving the living conditions of urban populations, but still face enormous challenges. This paper describes the roles of city and other local governments in designing housing policies and integrating them into governance, planning and finance. This includes many innovations in local governments’ housing policies, especially those implemented in the first decade of this century by progressive city governments. It also includes decentralization that supported municipal governments to develop their housing and urban development plans. Relevant as well are policies to address the quantitative deficit (insufficient supply of housing) and the qualitative deficit (inadequate quality of housing), such as informal settlement upgrading. The paper includes examples of where housing policy decentralization created spaces for democratic, participatory and inclusive city governance. It also highlights the importance for social housing of finance and the measures that may be taken to address this, including land management instruments and capture of real estate surplus value. But much of this innovation has been lost over the last decade, after the economic crisis and the rise of a new wave of conservative regimes in the region.
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Kohlhepp, Gerd. "Scientific findings of Alexander von Humboldt's expedition into the Spanish-American Tropics (1799-1804) from a geographical point of view." Anais da Academia Brasileira de Ciências 77, no. 2 (June 2005): 325–42. http://dx.doi.org/10.1590/s0001-37652005000200010.

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Alexander von Humboldt's expedition from 1799 till 1804 to the "equinoctial regions of the new world" led through Venezuela, Cuba, Colombia, Ecuador, Peru, and Mexico. In Europe an increased knowledge of the "New World" was connected with the privately funded journey, which served purely scientific purposes and had nothing to do with the exploration and exploitation of natural resources. Besides the research results, which were based on new measuring methods and the quantitative ascertainment of scientific basics, the journey also made possible detailed descriptions in matters of regional studies including social, socio-economic, political, and economic-geographic circumstances, which were based on empirical field studies. The expedition took place shortly before the political change in Latin America. Humboldt, who still experienced the feudal character of global economy based on slave labor in the colonies, vehemently criticized this economic structure - although he was a noble - and its unbearable social conditions. This is the reason why Humboldt is still admired in Latin America till this day. In Europe the scientific insights of his journey to the tropics and his innovative impulses in geog raphy as well as in many other disciplines brought him fame and lasting recognition as a universal scholar, who had crucial influence on the development of the sciences during the first half of the 19th century.
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Ciantelli, Chiara, Elisa Palazzi, Jost von Hardenberg, Carmela Vaccaro, Francesca Tittarelli, and Alessandra Bonazza. "How Can Climate Change Affect the UNESCO Cultural Heritage Sites in Panama?" Geosciences 8, no. 8 (August 7, 2018): 296. http://dx.doi.org/10.3390/geosciences8080296.

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This work investigates the impact of long-term climate change on heritage sites in Latin America, focusing on two important sites in the Panamanian isthmus included in the World Heritage List: the monumental site of Panamá Viejo (16th century) and the Fortresses of Portobelo and San Lorenzo (17th to 18th centuries). First of all, in order to support the conservation and valorisation of these sites, a characterisation of the main construction materials utilized in the building masonries was performed together with an analysis of the meteoclimatic conditions in their vicinity as provided by monitoring stations recording near-surface air temperature, relative humidity, and rainfall amounts. Secondly, the same climate variables were analysed in the historical and future simulations of a state-of-the-art global climate model, EC-Earth, run at high horizontal resolution, and then used with damage functions to make projections of deterioration phenomena on the Panamanian heritage sites. In particular, we performed an evaluation of the possible surface recession, biomass accumulation, and deterioration due to salt crystallisation cycles on these sites in the future (by midcentury, 2039–2068) compared to the recent past (1979–2008), considering a future scenario of high greenhouse gas emissions.
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Volosyuk, O. V., and N. A. Shkolyar. "Latin America in the fight against the Coronavirus crisis: The impact on economic and political stability in the region." Cuadernos Iberoamericanos 9, no. 2 (December 17, 2021): 28–47. http://dx.doi.org/10.46272/2409-3416-2021-9-2-28-47.

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The world has entered the third decade of the century, gripped by the global crisis and the COVID-19. These specific conditions have undermined the development and sustainability of the less prepared countries of Latin America and the Caribbean (LCA). The authors show that the COVID-19 pandemic was the largest shock for the LCA countries in the social and economic spheres. Before the pandemic, the LCA states had rather modest indicators of economic development. They were strongly influenced by external factors of protectionism opposition to the free trade and the looming global economic crisis. They have accumulated deep internal contradictions of social inequality and low domestic demand. The economic situation in the LCA countries has become even more complicated due to the development of a pandemic in 2020-2021: it was characterized by a halt or decline in economic activity, growing budget deficit and public debt, decline in domestic demand for goods and services, decreasing export revenues, declining investments, businesses closure, rising unemployment and poverty. To contain the spread of coronavirus, prevent overstrain of health systems and reduce human losses, the LCA governments took a number of measures to overcome the COVID-19 crisis, which came down to general measures of population social support and direct measures against the spread of the pandemic, including vaccination which has become an issue of utmost importance in the absence of local vaccines and a shortage of purchased vaccines or delivered under the COVAX program. However, as it is shown in the article, the measures taken by the LCA states to protect the population and the economy from the strikes of the pandemic are insufficient; vaccination programs are almost completely dependent on external vaccine manufacturers and international assistance.
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18

Vorotnikova, T. "Hard to Be Left: Foreign Policy Strategies of the New “Pink Tide” Governments in Latin America." World Economy and International Relations 67, no. 1 (2023): 101–10. http://dx.doi.org/10.20542/0131-2227-2023-67-1-101-110.

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The article reviews main principles and imperatives of the foreign policy provided by actual left-wing governments in Latin America. In a big number of countries in the region, politicians with leftist views have recently come to power. Among them there are the presidents of Argentina, Mexico, Bolivia, Peru, Honduras, Chile and Colombia. The scale of the new “Pink tide” suggests analogies to the “Left turn” that took place in the beginning of the 21st century. However, accents in the current agenda vary and nuances make the difference. The analysis of narrative and political practice of the left leaders shows that traditional commitment to the principles of anti-Americanism and anti-neoliberalism stay relevant. Idea of multipolarity and search for an alternative to US hegemony remain key issues to the international positioning of Latin American states. At the same time, they no longer intend to question liberal international order and global economic conditions. Problem of human rights and combat climate change are getting more important for Latin American countries. A special kind of vision on these global concerns can contribute to their diplomatic ambitions and increase their international status. The challenge of balancing between the two global powers, US and China, push to strengthen ties with the non-region states that belong to the “Global south”. Another attribute of the modern regional configuration is lack of an apparent locomotive in the current South American integration system. Too explicit dissimilarities in the strategies of left-wing governments do not give reasons for the emergence of a strong collective platform. The ideology of regionalism that appealed to the great united motherland, is being replaced today by a new configuration where the former interconnectivity between Latin American left regimes is not displayed and mini-lateral cooperation matters. Their realignment and new alliances will be fundamental to the regional balance.
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KRAVCHENKO, Kateryna. "FEATURES OF THE URBAN AGGLOMERATIONS DEVELOPMENT IN THE CONDITIONS OF CONTEMPORARY GLOBALIZATION." Ekonomichna ta Sotsialna Geografiya, no. 87 (2022): 72–81. http://dx.doi.org/10.17721/2413-7154/2022.87.72-81.

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The intensity of globalization processes and the role of cities in the socio-economic development of countries and regions increase at the current stage of society's development. Agglomerations that have the status of the global (world) level play the most crucial role. he purpose of the paper is to analyze the impact of globalization processes on the peculiarities of the development of urban agglomerations in the conditions of contemporary globalization, as well as to identify problems and prospects for their further evolution. The research was carried out based on the system, synergistic, informational and human-geographical approaches; using the methods of induction and deduction, comparison, analogy, analysis, synthesis, systematization, as well as mathematical, statistical and cartographic methods. Three waves characterized the spread of globalization in historical retrospect: the first one (the first half of the 20th century) described the intensive development of cities and industry, the development of transport infrastructure; the second wave (the second half of the 20th century) marked the formation of transnational, transcontinental and global corporations, the transfer of "dirty" industries to the territory of poor third world countries; the third (the beginning of the 21st century – until now) characterizes the emergence of urbanization beyond geopolitical and administrative borders. A significant trend in the contemporary development of cities is the tendency towards developing urban agglomerations, increasing their importance in contemporary spatial transformations and processes taking place on the planet. Agglomerations within regions of the world arose quite unevenly. The largest number are in the USA, Europe, and Asia, and agglomerations are growing at an accelerated pace in Africa and Latin America. Until the 20th century, the large agglomerations were formed mostly in developed countries and regions of the world due to the available resource and economic potential. Now the processes of intensive agglomeration are characterized for cities and developing countries, where the number of agglomerations is increasing. A significant increase in the number of cities and agglomerations in countries with a low level of development leads to the emergence and aggravation of global problems of modern times.
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Córdova González, Claudia Angélica, and Mónica Guadalupe Chávez Elorza. "Review of the International Patent System: From the Venice Statute to Free Trade Agreements." Mexican Law Review 13, no. 1 (July 2, 2020): 65. http://dx.doi.org/10.22201/iij.24485306e.2020.1.14810.

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The current international patent system emerged within certain economic, political and social conditions in specific territories and periods. It has its historical roots in the Statute of Venice (1474), the Statute of Monopolies (1624), the United States Patent Law (1790), the French Patent Law (1791) and the Paris Convention (1883). Over time, these laws shaped a new model, which currently prevails. To strengthen the analysis of this article, the Agreement on Trade-Related Aspects of Intellectual Property Rights (1994), as well as free trade twentieth century agreements are integrated into the discussion. It is worth noting that each amendment stressed the economic relevance of the patent and its use to benefit certain economic elites through the creation of monopolies. Consequently, the debate on the purposes and nature of the international patent system has also been constant from its emergence to the present. This article provides basic elements for reflection about the origin, purposes and scope of national patent models implemented in Latin America within the global trend of scientific-technological innovation for development.
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Krstic, Zoran. "Peronism as a model of social and political development: The modern Argentinian myth." Medjunarodni problemi 66, no. 1-2 (2014): 137–59. http://dx.doi.org/10.2298/medjp1402137k.

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The subject of the analysis in this paper is the study of the emergence and evolution of the phenomenon of Peronism as the most important political movement and ideology in Argentina and perhaps in Latin America throughout the 20th century. The basic aim of this paper is to present Peronism as a political movement and model of development which emerged during the rule of Juan Domingo Peron in the mid-20th century. This movement continued to exist and last after Peron?s demission from the political scene. In recent history Peronism became something more significant than a political movement or a social development model. Because of that, Peronism can be characterized as a myth. Nowadays, Perosnism is one of the crucial factors in the socio-economic and cultural development in Argentina. The focus of research in this paper is on the presentation and explication of the notions/topics concerning Peron, his movement and rule. These ones are populism, presidentialism and personalisation of power. Also, this paper will analyse the conditions, facts and circumstances under which Peronism emerged and survived in spite of many critics and disputes in the scientific literature as well in the Argentinian politics and society.
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Forrai, Judit. "A járványos gyermekbénulás elleni vakcina a politikai és szakmai harc hálójában." Kaleidoscope history 10, no. 21 (2020): 75–91. http://dx.doi.org/10.17107/kh.2020.21.75-91.

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The discovery of the polio pathogen and the development of eradication procedures represented a giant step in the man’s history. They demonstrated clearly the diversity of scientific approaches. Infectious diseases of poliovirus like other ones follow an ever-changing pattern. Examined in the global context, these changes burdened society from the very beginning. The invention of any vaccine did not result in peace of mind, because not only its quality but the effect of variable conditions must have been constantly monitored due to the changing patterns of viruses. Polio or poliomyelitis causes paralysis and death. Its history goes back to the prehistoric times thus the first evidence was found in the era of the 18th Dynasty in Egypt BC cc 400-1365 cut in stone. Although major polio epidemics were unknown before the 20th century, minor and sporadic endemics were always emerging. But after the turn of the century in the 1900s major epidemics started in North America and Europe at the same time, instigating intensive research in a number of laboratories using different methodological approaches. First, the pathogen was identified and then the vaccine developed. Finally remained 2 different vaccines on the market. The inactivated polio vaccine (IPV) was the first one administered at the beginnings after the discovery by Salk, changed later by the oral polio vaccine (OPV) in many countries. Political, health policy and mainly economic struggle were launched in the production of vaccines. This study presents the historical and political background that characterized and characterizes a pandemic. Back in the Cold War era, we demonstrate the business-economic-political-institutional background of the worldwide vaccine production, without neglecting the researchers’ individual competition and envy especially through highlighting the background of the Nobel Prize struggle.
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Schurman, Rachel A. "Uncertain Gains: Labor in Chile's New Export Sectors." Latin American Research Review 36, no. 2 (2001): 3–29. http://dx.doi.org/10.1017/s0023879100018975.

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AbstractNatural-resource-based export-oriented growth strategies have resurfaced as the dominant development approach in Latin America. While a growing literature exists on the economic, equity, gender, and environmental impacts of this development strategy, insufficient attention has been paid to its significance for labor. This article seeks to help fill this gap by analyzing its effects on Chilean workers. Based on a study of the fruit, forestry, and fishing sectors, my work shows that this type of development strategy can be very labor-absorbing and can offer significant benefits for labor when it leads to “agro-industrialization.” Nonetheless, although working conditions clearly improved after the late 1980s, it is likely that the first decade of the twenty-first century will not be a repeat of the 1990s. The hypercompetition that now characterizes these sectors is putting tremendous pressure on firms to reduce costs, including that of labor. Stripped of basic state protections and left with little social power, Chilean workers are much more vulnerable than they were before.
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Caetano, Camila Carla da Silva, Lívya Alves Oliveira, Ana Teixeira Nogueira, Lindomar José Pena, and Ceres Mattos Della Lucia. "SARS-COV-2 pandemic: the food insecurity and social inequalities in Brazil." Journal of the Food and Culture of the Americas 2, no. 2 (December 31, 2020): 183–95. http://dx.doi.org/10.35953/raca.v2i2.79.

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The COVID-19 pandemic has resulted in the most severe global public health crisis in the last century. SARS-CoV-2 emerged in China in December 2019, and since then, it has been quickly spreading around the world. After Europe and North America, the virus has arrived in Latin America. Among the developing countries, Brazil has been the most affected by the pandemic causalities, which is a concern, since social and economic disparities may favor its severity. In an attempt to reduce virus transmission, public health measures have been implemented by the states, despite the lack of assistance from the Brazilian federal government. Implementing social distancing and hygiene measures have not been possible, mainly due to the unfavorable social conditions of economically vulnerable people. Thus, the pandemic is exposing the evidence of social inequalities in the country, which in turn deepens the public health crisis. Here, we discuss evidence from relevant topics that are influencing the course of the pandemic in Brazil, including food insecurity, social aspects and public health political issues. The pandemic has exposed the need for maintaining and improving the social care and food security of vulnerable groups as well as the harm of ignoring them. Thus, more effective mitigation measures must be thought and applied in Brazil to improve the handling of this pandemic and the next ones.
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Salhi, Hanifa. "The development in West and East: between model and modelling." Acta Europeana Systemica 3 (July 14, 2020): 39–48. http://dx.doi.org/10.14428/aes.v3i1.57433.

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The recurring question asked for more than a century is why does the West dominate the world? Is it a matter of fate shifting between the West and the East? Does this supremacy result from the fact that developed countries in the western world impose their economic determinism and organizational methods upon developing countries? Does this power relationship inhibit the aspirations of vulnerable people to straighten the balance of power? Or is the East simply waning with the slow and tedious pace of development? Such as Iam MORRIS indicates that the supposed greatness of the West would be less the result of a Western power that of a decline in the East? The remarkable mounted of some emerging countries of Eastern Europe and Latin America appears as a dynamic regulator of this dominance, but announced in part, against serious economic problems (financial crisis, depletion of energy resources, new technology revolution, uneven development, food insecurity, climate change ...) and possibly social (relations between state and market deregulated social contract violated in the context of increasing inequality). Under these conditions the ascent tends to refer this absolute Western domination and calls to speculate on the issue of economic dynamism and structural weakness of an established model that is the Western model. Our work will lay out the ideas that discuss the failure to import foreign models by vulnerable countries and the need for a creative modelling work in a systemic perspective, and will hence tackle the conception of civilization and development from an eastern point of view.
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Pabst, Adrian, and Roberto Scazzieri. "Virtue, Production, and the Politics of Commerce: Genovesi’s “Civil Economy” Revisited." History of Political Economy 51, no. 4 (August 1, 2019): 703–29. http://dx.doi.org/10.1215/00182702-7685197.

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Antonio Genovesi’s economic-political treatise on civil economy was a major contribution to debates in the mid-and late eighteenth century on the nature of political economy. At that time, Genovesi’s book was extensively translated and discussed across continental Europe and Latin America, where it was read as a foundational text of political economy similar to Adam Smith’s Wealth of Nations. The aim of this article is to contribute to the analysis of the mutual implication between the economic and the political order of society by revisiting Genovesi’s theory of civil economy, which he defined as “the political science of the economy and commerce.” First, the article retraces Genovesi’s conception of civil economy as a branch of political science and the role of “virtue” in ordering the polity according to “the nature of the world.” Second, it explores Genovesi’s theory of production as an inquiry into the proportionality conditions that productive activities should meet for a well-functioning polity to persist over time. Third, our argument emphasizes the importance of Genovesi’s analysis of production structures for his theory of internal and foreign trade. In this connection, the paper investigates Genovesi’s idea that the maintenance of a country’s “trading fund” should be the fundamental objective for its internal and external trade policies. These policies, according to Genovesi, should be consistent with the context of the body politic under consideration and the economy’s proportionality requirements for any specific stage of development.
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ERSOY, Yusuf. "Endüstri 4.0'ın Uygulanmasındaki Avantajlar ve Engeller ve Endüstri 4.0'ın Temel Özellikleri." Journal of International Scientific Researches 7, no. 3 (October 7, 2022): 207–14. http://dx.doi.org/10.23834/isrjournal.1122471.

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Since the publication of the term "Industry 4.0" in 2011, the digital transformation required by Industry 4.0 has immediately attracted the attention of industrialists and governments around the world. Majority of the countries around the world are dealing with the difficulty of producing more goods from limited and consumed natural resources to meet the ever-increasing consumer demand worldwide with the first industrial revolution in the 18th century due to environmental and vital issues. Therefore, the sustainability impacts of Industry 4.0 and the way it contributes to sustainable economic, environmental and social development are getting more and more attention. Nowadays, Industry 4.0 is about digitalization in all industrial and consumer markets, from smart production systems to all distribution channels. Industry 4.0 digital transformation involves the digitization and integration of the entire value chain of the product life cycle. Industry 4.0 is a technological concept that contributes to the sustainability of businesses in today's conditions. Industry 4.0 changes the organization, business models, products, supply chain and strategies of companies. Industry 4.0 enables businesses to be more agile and flexible by integrating people, machines and data. Nowadays, countries such as Germany, the United States of America, India, China, Japan, the United Kingdom and Brazil have been developing policies for the implementation of Industry 4.0. However, the adequacy and implementation of Industry 4.0 technologies can be difficult for both industry representatives and countries. In this research, the advantages and barriers in implementing of Industry 4.0 were expressed. In addition, Industry 4.0 and its main features have been explained.
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Aleksiayevych, H. V. "Czech borrowings in the Old Belarusian and Old Ukrainian written languages." Movoznavstvo 317, no. 2 (April 20, 2021): 36–54. http://dx.doi.org/10.33190/0027-2833-317-2021-2-003.

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The article assesses the role of the Old Belarusian and the Old Ukrainian languages in the development of Czech-Eastern Slavonic linguistic relations in the 14th–18th centuries. There were both direct and indirect ways of Czech language influence on the Old Belarusian and the Old Ukrainian written languages. The 15th century saw favourable conditions for military-political alliance between the Grand Duchy of Lithuania and Bohemia. The emergence and development of these relations was accompanied by diplomatic activity: for instance, Grand Dukes Vitovt and Svidryhailo had correspondence in Latin and Old Czech with the Czech Hussites. Contacts in the military-political, socio-religious and cultural-educational spheres contributed to the development of Czech-East Slavic language ties. Translations of the Czech written texts into Old Belarusian and Old Ukrainian («The Life of Alexei the Man of God», «The Story of Apollo of Tyre», «Lucidarius», «The Song of Songs», «The Tale of Toadal», «The Tale of the Prophetess Sibylline», «The Trojan Story»), use of the Czech legal texts in writing Galicia-Volyn letters in the 14th and early 15th centuries. The use of Czech legal texts in Galicia-Volyn monuments (Norman Statute of 1438–1439, Statutes of 1529, 1566, 1588, Lithuanian Metric Acts) contributed to the direct penetration of Bohemianisms into the Old Belarusian and Old Ukrainian writing. Although there were channels through which Czech linguistic elements could be directly borrowed into Old-Belarusian and Old-Ukrainian, the main channel for their penetration was Polish. Through the Polish mediation Bohemian loanwords were borrowed from various lexical-semantic groups, mainly from religious, military, socio-political and economic, everyday life vocabulary. The similar conditions of borrowing of Bohemianisms in Old Belarusian and Old Ukrainian are obviously the main reason why Bohemianisms in both languages are close in number and chronology of written fixation. This similarity is especially noticeable against the background of Old Russian data, where bohemisms were recorded later and in smaller numbers
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Дієго Феліпе Арбелаез-Кампіллo, Магда Джулісса Рохас-Багамон, and Олег Геннадійович Данильян. "DISCOURSE ON THE CATEGORIES «UNIVERSAL CITIZENSHIP”, «HUMAN RIGHTS» AND «GLOBALIZATION»." Bulletin of Yaroslav Mudryi National Law University. Series:Philosophy, philosophies of law, political science, sociology 1, no. 48 (March 9, 2021): 11–33. http://dx.doi.org/10.21564/2075-7190.48.224374.

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Problem setting. Although modern humanity has proclaimed the universality of human dignity and desperately upholds this value, which is fully in harmony with freedom, equality and fraternity, the truth is that in reality it has not yet been able to go beyond the status of a citizen of the nation state in its legal and political conventions. . In this sense, a very important issue is the representation of the real situation around the categories of "universal citizenship", "human rights" and "globalization" in the midst of the geopolitical conflict in Latin America caused by the persecution of 21st century socialism. Paper objective. This critical essay aims to discuss the real significance of such political and legal categories as "universal citizenship", "human rights" and "globalization" in the midst of the geopolitical conflict that led to the persecution of 21st century socialism in Latin America. Methodology. The methodological field of the research uses documentary observation and dialectical hermeneutics, which help to compare and reconcile categories with different semantic contexts to reconstruct their true meaning. The technique of writing this research was the methodological procedure of the hermeneutic circle, which is a sequential analysis of numerous written documentary sources, combined in a kind of dialogic context with hidden messages that can be read between the lines, as well as interpretive theories and critical thinking. Paper main body. There is much in common between the contemporary political and philosophical programs of the Western cultural space, of which Latin Americans are a part, and the ideas of universal citizenship, globalization, and human rights in a spirit of deep militant universalism that function fully today not only as abstract theories at the disposal of peoples and nations who continue to work to improve their living conditions and strengthen their freedom to exist and act in a better world. As for the tradition of human rights as a modern expression of natural law, it dates back to ancient times and even dates back to the great religions, which in their own way developed and substantiated the idea of human dignity. The history of the Institute of Human Rights has a pronounced anthropocentric character and deserves to be expanded in accordance with the geopolitical realities of the modern world, in order to protect the indisputable value of all life forms affected by such phenomena as global warming and the associated greenhouse effect. economic growth that requires technological and industrial modernization. For its part, "globalization with a human face" means the ability to interconnect and enrich not only material and financial resources, due to the insatiability of international markets, but also the cycle of knowledge and people required by modern world democracies to strengthen their social and human capital. . In this context, the idea of global or universal citizenship, while seeming utopian, is of paramount importance as it broadens the political phenomenon of citizenship, which is vital to modern democracies or polyarchies, forgetting the tradition of history ruled by supreme forces and structures. Although, according to K. Popper, already the historicist concept assigned a fundamental role in building a reality conducive to the exercise of freedom, the citizen, conscious and active. Thus, if globalization is reduced purely to the internationalization of capital and selective human and technological resources solely in the interests of corporate elites and does not turn into a globalization of social welfare and dignity - a process in which universal citizenship would be a logical consequence, then partial globalization, which can do little to promote an open society in the 21st century. Conclusions of the research. The study concludes that if globalization is reduced to the internationalization of capital and individual human and technological resources for the benefit of the corporate elite and does not extend to the globalization of social welfare and dignity, where universal citizenship would be a logical consequence, such globalization is unlikely to contribute building an open society of the XXI century.
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Losada Romero, Cesar. "A new New Babylon. Bottom-up Urban Planning & The Situationist utopia." Joelho Revista de Cultura Arquitectonica, no. 7 (December 25, 2016): 104–15. http://dx.doi.org/10.14195/1647-8681_7_8.

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The recent “Participatory Turn” in Urbanism has flourished most significantly in situations of economic turmoil, material scarcity and technical insufficiency: those circumstances have boosted creative and audacious urban processes that take advantage of such limitations as an opportunity to enhance social engagement, formal exploration and developmental experimentation. All across Europe or Latin America, multidisciplinary collectives aim to reinvent the socioeconomical conditions for urban design and construction, favoring the architectural Process rather than the Object.Experiences in Urban Acupuncture, bottom-up urbanism, activism for the public space and the claim for neighborly ties are often struggling against Top-Down urban planning and the modern articulation of the zoned city: according to some of these collectives, the Welfare State and its urban culture has been overtaken by capitalism, and the classical Ville Radieuse model has somehow become synonymous with Corporatocracy and social engineering.In this sociopolitical milieu , some of the mid twentieth century arguments against the Modern Movement have emerged again. Many scholars have linked the Occupy and Indignados movements with the events of May 68, and the urban guerrillas within both periods have been strongly biased towards a radical reformulation of the Structuralist urban parameters: in order to re-humanize the city, urban planning must give way to spontaneity, autopoiesis, dynamism and horizontal decision-making. The city is not considered a ready made object designed from scratch, but an always-evolving living entity, where perennial mutation and reconfiguration is the at the key feature. The City is a rhizome rather than a tree.The Situationist utopia of the New Babylon (as conceived by Constant Nieuwenhuys) revives as the core intellectual reference of many Participatory Urbanism experiences. Psycho-geography, détournement, the urban dweller as a homo ludens, and the harmonization of life and work are presented as the shield against the alienation, social segregation and gentrification inherent to the capitalist city and its planning instruments. The Situationist model is now enhanced with ideas of sustainability, social responsibility, gender claims, global migrations and ecology, depicting a contemporary Utopia that collapses the boundary between planners and dwellers.In this paper we´ll trace the influence of the Situationist ethos upon recent experiences in participatory urbanism: the impact of mid-twentieth century radical activism upon contemporary counter-cultural urban praxis, a trend that is pushing the Academia to reconsider its ethical foundations and methodological tools, and ultimately to reformulate the consensual ontology of the city inherited from the early Modern Movement.
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Piscos, James Lotero. "“Humanizing the Indios” Early Spanish missionaries’ struggles for natives’ dignity: Influences and impact in 16th Century Philippines." Bedan Research Journal 7, no. 1 (April 30, 2022): 158–82. http://dx.doi.org/10.58870/berj.v7i1.36.

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Spanish conquest in the New World has two sides, evangelization, and colonization. The former was carried by the missionaries who were heavily influenced by Bartolome de Las Casa and Vitoria, while the latter by conquistadores, the defenders of the conquest. Early missionaries fought for the dignity of the Indios where they clashed with the motives of the conquistadores to exploit human resources. The problematic part was they have to work under the Spanish crown where their point of contact was also their area for friction. When they arrived in the Philippines, that social solidarity and dynamics of social relation continued where it became complex due to the involvement of various groups including the natives and their leaders, the religious orders, and most of all the Spanish Royal Court that had the history of having a heart for the Indians. King Philip II created a space for debates within his agenda of social conscience. Using Durkheim’s structuralist-functionalist approach, historical narratives about early missionaries’ struggles for natives’ dignity in the 16th century Philippines were examined. Durkheim’s social solidarity, dynamics of social relations, and his concepts of anomie as disruptions due to dramatic changes and conflicts were utilized as tools to analyze the quest for total well-being. The achievement of sustainable development goals (SDGs) is authenticated in amplifying the value of human dignity, equality, and respect for each individual. With this, the 500 years of Christianity in the Philippines is worth the celebration.ReferencesAbella, G. (1971) From Indio to Filipino and some historical works. Philippine Historical Review. (Vol. 4).Arcilla, J. S. S.J. (1998). The Spanish conquest. Kasaysayan: The story of the Filipino people. (Vol. 3). C & C Offset Printing Co., Ltd.Bernal, R. (1965). “Introduction.” The colonization and conquest of the Philippines by Spain: Some contemporary source documents. Filipiniana Book Guild.Burkholder, M. (1996). “Sepulveda, Juan Gines de.” Encyclopedia of Latin American history and culture. (Vol.5). Edited by Barbara A. Tenenbaum. Macmillan Library Reference.Burkholder, S. (1996). “Vitoria, Francisco de.” Encyclopedia of Latin American history and culture. (Vol.5). Macmillan Library Reference.Tenenbaum, B. (ed). (1996). “Sepulveda Juan Gines de” in Encyclopedia of Latin American history and culture (Vol. 5) Macmillan Library Reference.Cabezon, A. (1964) An introduction to church and state relations according to Francisco Vitoria. University of Sto. Tomas. Cathay Press Ltd. (1971). Spain in the Philippines: From conquest to the revolution.Catholic Bishops’ Conference of the Philippines (CBCP) (2020). Pastoral letter celebrating the 500th Year of Christianity in the Philippines. https://cbcpnews.net/cbcpnews/wp-content/uploads/2021/ 03/500-YOC-CBCP-Pastoral-Statement-Final.pdf.Charles V. (1539) De Indis, Letter of Emperor Charles V to Francisco Vitoria, Toledo.Cushner, N. (1966). The isles of the west: Early Spanish voyages to the Philippines, 1521-1564. Ateneo de Manila Press.Dasmarinas, G. (1591). Account of Encomiendas in Philipinas. Blair, E. and R. (1903) (Vol. 8) (eds. at annots). The Philippine Islands, 1493-1898 Vol.3: Explorations by early navigators, descriptions of the islands and their peoples, their history and records of the catholic missions, as related in contemporaneous books and manuscripts showing the political, economic, commercial and religious conditions of those islands from their earliest conditions with European nations to the close of the nineteenth century. Arthur H Clark. Hereinafter referred to as B and R.De la Costa, H. (1961). Jesuits in the Philippines. Harvard University Press.De la Rosa, R. (1990). Beginnings of the Filipino Dominicans. UST Press.De Jesus, E. (1965). “Christianity and conquest: The basis of Spanish sovereignty over the Philippines.” The beginnings of Christianity in the Philippines. Philippine Historical Institute.Digireads.com. (2013). The division of labor. https://1lib.ph/book/2629481/889cf4Donovan, W. (1996). “Las Casas, Bartolome.” Encyclopedia of Latin American history and culture (Vol.3). Macmillan Library Reference.Durkheim, E. (2005). Suicide: A study on sociology. Routledge.Durkheim, E. Mauss, M., & Needham, R. (2010) Primitive Classification. Routledge.Duterte, R. (2018). Executive Order No.55. https://www.officialgazette.gov.ph/downloads/2018/05may/20180508-EO-55-RRD.pdf.Ferrante, J. (2015). Sociology, a global perspective. Cengage Learning.Gutierrez, L. (1975). “Domingo de Salazar’s struggle for justice and humanization in the conquest of the Philippines.” Philippiniana Sacra 14.Harvard University. (1951). Jurisdictional conflicts in the Philippines during the XVI and XVII.Lavezaris, M. (1569) Letter to Felipe II in B and R (1903) (Vol. 3).Licuanan, V. and Mira J. (1994). The Philippines under Spain: Reproduction of the original spanish documents with english translation (Vol. 5). National Trust for Historic and Cultural Preservation of the Philippines.Lietz, P. (Trans). (1668). Munoz Text of Alcina’s History of the Bisayan Islands. Philippine Studies Program. XXV(74). National Quincentennial Committee (2021). Victory and Humanity. https://nqc.gov.ph/en/resources/victory-and-humanity/Lukes, S. (ed) (2013) The rules of sociological method. Palgrave Macmillan.National Trust for Historic and Cultural Preservation of the Philippines. (1996). The Philippines under Spain: Reproduction of the original Spanish documents with English translation (Vol 6).Piscos, J.L. (2017). Human Rights and Justice Issues in the 16th Century Philippines. Scientia, The international journal on the liberal arts. San Beda College. https://scientia-sanbeda.org/wp-content/uploads/2017/12/2-piscos.pdfPorras, J.L. (1990). The synod of Manila of 1582. Translated by Barranco, Carballo, Echevarra, Felix, Powell and Syquia. Historical Conservation Society.Munoz, H. (1939). Vitoria and the Conquest of America.Rada. M. (1574) Opinion regarding tributes to the Indians in B and R (1903) (Vol.3).Rafael, V. (2018) Colonial contractions: The making of the modern Philippines, 1565–1946. https://www.academia.edu/ 41715926/Vicente_L_Rafael_Colonial_Contractions_The_ Making_of_the_Modern_Philippines_1565_1946_Oxford_Modern_Asia.Recopilacion de Leyes de los Reynos de las Indias. (1943). Tomo I.Roberts, D. (2021) The church and slavery in Spain. https://www.academia. edu/49685496/THE_CHURCH_AND_SLAVERY_IN_NEW_SPAIN.San Agustin, G. (1998). Conquistas de las Islas Filipinas: 1565-1615. Translated by Luis Antonio Maneru. Bilingual Edition. San Agustin Museum.Schaefer, R. (2013). Sociology matters. McGrawHill.Scott, J.B. (1934) Francisco de Vitoria and his law of nations. Oxford Press.Scott, W.H. (1991). Slavery in the Spanish Philippines. De la Salle University Press.Szaszdi, I. (2019). The “Protector de Indios” in Early Modern Age America. University of Valladolid: Journal on European History of Law, Vol. 10. https://www.academia.edu/43493406/The_Protector_de_Indios_in_early_Modern_Age_America on August 4.United Nations Development Program (2015). What are the SustainableDevelopment Goals?. https://www.undp.org/sustainabledevelopment-goals?utm_source=EN&utm_medium=GSR&utm_content=US_UNDP_PaidSearch_Brand_English&utm_campaign=CENTRAL&c_src=CENTRAL&c_src2=GSR&gclid=CjwKCAjwgr6TBhAGEiwA3aVuITYSRlHJDYekFYL-lXHAxzBAO5DWwd2kUCDjhvuRglDj Z1F6dFIUFxoCoOwQAvD_BwEUniversity of Santo Tomas. (1979). “Domingo de Salazar, OP, First Bishop of the Philippines (1512-1594): Defender of the Rights of the Filipinos at the Spanish Contact” Philippiniana Sacra XX.University of Santo Tomas. (2001). Domingo de Salazar, OP, First Bishop of the Philippines, 1512-1594.University of Santo Tomas. (1986). “Opinion of Fr. Domingo de Salazar, O.P. First bishop of the Philippines and the major religious superiors regarding slaves.” Philippiniana Sacra. 22(64).University of Santo Tomas. (1986). “Domingo de Salazar’s Memorial of 1582 on the status of the Philippines: A manifesto for freedom and humanization.” Philippiniana Sacra 21(63).University of Santo Tomas. (1990). “The Synod of Manila: 1581-1586.” Philippiniana Sacra.University of the Philippines-Diliman. (2007). Church-state politics in the justice issues of the 16th Century Philippines. Unpublished Dissertation,Villaroel, F. (2000). “The Church and the Philippine referendum of 1599.” Philippiniana Sacra (Vol.XXXV).Yale Courses. (2011). Durkheim’s theory of Anomie. 23. Durkheim's Theory of Anomie - YouTubeZaide, G. at annots. (1990). Documentary sources of Philippine history. (Vol. 2). National Bookstore.
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Norden, Larisa Lvovna. "Investigation the need to teach the characteristics of the development of parliamentarism in Latin America as part of education." Propósitos y Representaciones 9, SPE3 (2021). http://dx.doi.org/10.20511/pyr2021.v9nspe3.1292.

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The article highlights the history and features of parliamentarism development in the Latin America countries. In addition, the need for training on the subject and the effect of increasing students and educators’ awareness in this field is examined. This process was lengthy, replete with the examples of various social groups, political trends and parties struggle intensity increase. Since the beginning of the 19th century, there have been almost no favorable conditions for the practical implementation of democratic government in the countries of Latin America, and the institutionalization of the party system has not taken place yet. However, there have been exceptions to the general rule in the history of Latin America. Chile and Argentina were such an example. The success of democratic transformations in the countries of the region depended on various reasons: a) whether the country had a democratic experience in its past; b) the conditions for the political and economic development of this country to develop representative institutions in the future; c) the importance of the parties in the political course development and the adoption of state decisions. The results of democracy and parliamentarism development in the states of Latin America are rather complicated by the turn of the 20th and 21st centuries. On the one hand, the last decades of the XX-th century and the beginning of this century was marked by the democratization of political life, reforms, and the replacement of military regimes with civilian governments. Since the beginning of the 60-ies, they started the process of democratization and formation of independent island states in the Caribbean and Central America. Despite the successful development of the economy, culture, education, the presence of a large middle class in Argentina, the military governments overcame civilian ones in the 30-70-ies. Therefore, it is needed to consider this aspect as a part of education system to improve the educators’ level.
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"Panama." IMF Staff Country Reports 19, no. 11 (January 17, 2019). http://dx.doi.org/10.5089/9781484394007.002.

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Panama has had the longest and fastest economic expansion in recent Latin American history. The economy has expanded at an average rate of about 6 percent per annum over the last quarter of a century, with Panama achieving one of the highest per capita income in Latin America. More recently, GDP grew by about 5½ percent in 2017 (driven by the expanded Canal), and then slowed to 3¾ percent (y/y) in H1-2018. Inflation remained subdued, reaching almost 1 percent (y/y) in September 2018. The external current account deficit stayed at 8 percent of GDP in 2017, mostly covered by FDI. The fiscal position continued to be strong, with the overall deficit of the non-financial public sector (NFPS) at about 1½ percent of GDP. Credit growth has decelerated as financial conditions have started to tighten.
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Schaefer, Timo. "Growing Up Indio during the Mexican Miracle: Childhood, Race and the Politics of Memory." Journal of Latin American Studies, February 23, 2022, 1–22. http://dx.doi.org/10.1017/s0022216x22000025.

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Abstract This article explores the childhood of a Mexican Indigenous activist, Raúl Javier Gatica Bautista, who was born in 1963 in the Oaxacan market town of Tlaxiaco. Growing up in poor circumstances, Gatica would become a leader in the social movements that between the 1980s and early 2000s pushed Mexico toward gradual democratic reform. The article seeks to describe what it was like to grow up poor and Indigenous at a time (later dubbed the Mexican Miracle) of impressive social and economic advances. Paying special attention to the experience of racial abuse, the article also asks how Gatica's childhood came to inform his political militancy. While other historians have linked the phenomenon of political radicalism in twentieth-century Latin America to particular social conditions, or to the influence and adaptation of global ideologies, this article seeks the origins of Gatica's radicalism in the experience of a racialised childhood.
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"TRANSFORMATION OF POLITICAL MODES IN THE CONDITIONS OF GEOPOLITICAL TURBULENCE." Journal of V. N. Karazin Kharkov National University. Issues of Political Science, no. 36 (2019). http://dx.doi.org/10.26565/2220-8089-2019-36-01.

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The article analyzes the key factors, trends and prospects for the transformation of political regimes in the context of transition to a polycentric world order. Geopolitical uncertainties are causing significant apprehension among elite and scientists at the beginning new era. This is due to some change in the hegemony of the world powers. The nature of hegemony, changing world order received special attention in the twentieth century and remains in the focus of researches to this day I Wallerstein stressed that the hegemonic states must be powerful to receive the benefits of its status. «Unipolar order» in world politics has turned out to be dysfunctional in terms of ensuring global prosperity and security, promoting democratic practices, and strengthening world order and stability across all regions. Destabilization of the entire world order is due to aggravating internal political divisions and confrontations in the USA and in the countries of the European Union. Processes of reforming new geopolitical coalitions have provided geopolitical turbulence. Turbulent world of international relations and politics is characterized by two overarching trends: (1) the supersession of geopolitics by geoeconomics; (2) mutations of the international security which is increasingly shifting from the interstate level to security threats the growing importance and intensity of conflicts between different value systems and ideologies, in particular between integrationist (such as democracy and human rights) and particularistic ideologies (such as nationalism or religious fundamentalism). Confrontation of the processes of Westernization and Easternization means the weakening of influence of Western countries and strengthening of Eastern. According to some forecasts, economic and technological revolutions will change the economies and social structures of societies; social and democratic revolutions will exert pressure on different levels of government; the geopolitical revolution will create a multipolar world. In the conditions of geopolitical turbulence main courses of power are eroded and predict the trajectories of the transformation of political regimes in the coming decades, especially in the face of strengthening Asia and Latin America, is too complicated.
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Piscos, James Loreto. "Human Rights and Justice Issues in the 16th Century Philippines." Scientia - The International Journal on the Liberal Arts 6, no. 2 (December 30, 2017). http://dx.doi.org/10.57106/scientia.v6i2.77.

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In the 16th century Philippines, the marriage of the Church and the State was the dominant set-up by virtue of Spain’s quest for colonization and evangelization. Civil administrators and church missionaries were called to cooperate the will of the king. Inmost cases, their point of contact was also the area of friction because of their opposing intentions. The early Spanish missionaries in the 16th century Philippines were influenced by the teachings of Bartolome de Las Casas and Vitoria that ignited them to confront their civil counterparts who were after getting the wealth and resources of the natives at the expense of their dignity and rights. Since the King showed interest in protecting the rights of the Indians, Churchmen used legal procedures, reports and personaltestimonies in the Royal Court to create changes in the systems employed in the islands. The relationship between the Spaniards and the natives cannot be reduced to a monolithic relationship between the two races. The power dynamics should be viewed within the plethora of groups who were engaged in the discourse including the bishop of Manila, governor-general, encomenderos, adelantados, soldiers, religious orders, native leaders and even the common indios. Given the canvas of conflicting motives, the proponents of conquests and missionary undertakings grappled to persuade the Spanish Royal Court to take their respective stand on the disputed human rights and justice issues on the legitimacy of the conquest, tributes, slavery and forced labor. References Primary Documentary Sources Anales Ecclesiasticos de Philipinas: 1574-1682. Volume 1. Manila: Archdioceseof Manila Archives, 1994. Arancel. Quezon City: Archivo de la Provincia del Santo Rosario (APSR), MSTomo 3, Doc.3. Blair, Emma Helen and Robertson Alexander, eds. at annots. The Philippine Islands,1493-1898: Explorations by Early Navigators, Descriptions ofthe Islands and Their Peoples, their History and Records of the CatholicMissions, as related in Contemporaneous Books and ManuscriptsShowing the Political, Economic, Commercial and Religious Conditionsof Those Islands from Their Earliest Conditions with European Nationsto the Close of the Nineteenth Century. 55 Volumes. Cleveland: ArthurH Clark, 1903-1909. Hereinafter referred to as B and R. The followingprimary documents were used in this dissertation: Colin-Pastells. LaborEvangelica I. Historical Conservation Society. The Christianizationof the Philippines. Manila: Historical Conservation Society, 1965. Keen, Benjamin, Editor. Latin American Civilization: History and Society, 1492to the Present. London: Westview Press, 1986. Las Casas, Bartolome. Historia de las Indias. Mexico, 1951. __________________. The Spanish Colonie. University Microfilms Inc., 1996.Licuanan, Virginia Benitez and Mira Jose Llavador, eds and annots. PhilippinesUnder Spain. 6 Volumes. Manila: National Trust for Historical and Cultural Preservation of the Philippines, 1996. Munoz Text of Alcina’s History of the Bisayan Islands (1668). Translated byPaul S. Lietz. Chicago: Philippine Studies Program, 1960. National Historical Commission, Coleccion de Documentos Ineditos de Ultramar,Madrid, 1887. Navarette, Martin Fernandez D. Colleccion de los Viajes y descubrimientos queHicieron por mar los espanoles desde fines del siglo XV. Madrid: 1825-1837. Pastells, Pablo. Historia General de Filipinas in Catalogo de los DocumentosRelativos a las Islas Filipinas. Barcelona, 1925. Recopilacion de Leyes de los Reynos de las Indias. Tomo I. Madrid, 1943.San Agustin, Gaspar de. Conquistas de las Islas Filipinas: 1565-1615. Translatedby Luis Antonio Maneru. Bilingual Edition. Manila: San Agustin Museum, 1998. Zaide, Gregorio, eds. at annots. Documentary Sources of Philippine History. 14Volumes. Manila: National Bookstore, 1990. Secondary Sources Books Chan, Manuel T. The Audiencia and the Legal System in the Philippines (1583-1900). Manila: Progressive Printing Palace, Inc., 1998. Cunningham, Charles Henry. The Audiencia in the Spanish Colonies: AsIllustrated by the Audiencia of Manila 1583-1800. Berkeley: Universityof California Press, 1919. Cushner, Nicolas P. The Isles of the West: Early Spanish Voyages to thePhilippines, 1521-1564. Quezon City: Ateneo de Manila Press, 1966. _________________. Spain in the Philippines: From Conquest to the Revolution. Aberdeen:Cathay Press Ltd., 1971. De la Costa, Horacio. Jesuits in the Philippines. Cambridge: Harvard UniversityPress, 1961. De la Rosa, Rolando V. Beginnings of the Filipino Dominicans. Manila: USTPress, 1990. Fernandez, Pablo. History of the Church in the Philippines. Manila: NationalBookstore, 1979. Gutierrez, Lucio, O.P. Domingo Salazar, OP First Bishop of the Philippines: 1512-1594. Manila: University of Santo Tomas Press, 2001. Haring, C.H. The Spanish Empire in America. New York: Harcourt, Brace andWorld Inc., 1963. Keen, Banjamin. A History of Latin America, 5th Edition. Vol.1. Boston: HoughtonMifflin Company, 1996. Keller, Albert Galloway. Colonization. Boston: 1908. Luengo, Josemaria. A History of Manila-Acapulco Slave Trade (1565-1815). Bohol:Mater Dei Publications, 1996. Munoz, Honorio. Vitoria and the Conquest of America: A Study on the FirstReading on the Indians. Manila: UST Press, 1938. _____________. Vitoria and War: A Study on the Second Reading on the Indians oron the Right of War. Manila: UST Press, 1937. Noone, Martin. The Islands Saw It.1521-1581. Ireland: Helicon Press, 1982. Pitrie, Sir Charles. Philip II of Spain. London: Eyre and Spottiswoode, 1963. Porras, Jose Luis. The Synod of Manila of 1582. Translated by Barranco, Carballo,Echevarra, Felix, Powell and Syquia. Manila: Historical Conservation Society, 1990. Rafael. Vicente. Contracting Colonialism. Quezon City: Ateneo de Manila Press, 1998. Santiago, Luciano P.R. To Love and To Suffer: The Development of theReligious Congregations for Women in the Spanish Philippines, 1565-1898. Quezon City: Ateneo de Manila Press, 2005. Scott, J.B. Francisco de Vitoria and His Law of Nations. Oxford, 1934.Scott, William Henry. Slavery in the Spanish Philippines. Manila: De la Salle UniversityPress, 1991. Shumway, David. Michel Foucault. Virginia: G. K. Hall and Co., 1989. Simpson, Lesley Byrd. The Encomienda in New Spain: The Beginning ofSpanish Mexico. Berkeley: University of California Press, 1966. Sitoy, Valentino Jr. The Initial Encounter: a History of Christianity in the Philippines,Vol. 1. Quezon City: New Day Publishers, 1985. Zafra, Nicolas. Readings in Philippine History. Manila. University of the Philippines, 1947. Zaide, Gregorio F. The Pageant of Philippine History Vol. 1. Manila: 1979. Articles Arcilla, Jose S. S.J., The Spanish Conquest. Kasaysayan: The Story of theFilipino People Vol. 3. Hongkong: C & C Offset Printing Co., Ltd, 1998. Bernal, Rafael. “Introduction.” The Colonization and Conquest of the Philippinesby Spain: Some Contemporary Source Documents. Manila: FilipinianaBook Guild, 1965. Burkholder, Mark A. “Sepulveda, Juan Gines de.” Encyclopedia of Latin AmericanHistory and Culture Vol.5. Edited by Barbara A. Tenenbaum. NewYork: Macmillan Library Reference, 1996. Burkholder, Susanne Hiles. “Vitoria, Francisco de.” Encyclopedia of Latin AmericanHistory and Culture Vol.5 Edited by Barbara A. Tenenbaum.New York: Macmillan Library Reference, 1996. De Jesus, Edilberto. “Christianity and Conquest: The Basis of Spanish SovereigntyOver the Philippines.” The Beginnings of Christianity in the Philippines.Manila: Philippine Historical Institute, 1965. Donovan, William. “Las Casas, Bartolome.” Encyclopedia of Latin American Historyand Culture Vol.3. Edited by Barbara A. Tenenbaum. New York:Macmillan Library Reference, 1996. Gutierrez, Lucio. “Domingo de Salazar’s Struggle for Justice and Humanizationin the Conquest of the Philippines.” Philippiniana Sacra 14, 1975. ____________. “Domingo de Salazar, OP, First Bishop of the Philippines (1512-1594): Defender of the Rights of the Filipinos at the Spanish Contact”Philippiniana Sacra XX, 1979. ____________. “Domingo de Salazar’s Memorial of 1582 on the Status of the Philippines:A Manifesto for Freedom and Humanization.” Philippiniana SacraVol. 21, No. 63, 1986. ___________. “Opinion of Fr. Domingo de Salazar, O.P. First Bishop of the Philippinesand the Major Religious Superiors Regarding Slaves.” PhilippinianaSacra Vol. 22, No. 64, 1986. ___________. “The Synod of Manila: 1581-1586.” Philippiniana Sacra Vol. XXV, No.74, 1990. Keith, Robert G. “Encomienda,Hacienda and Corregimiento in Spanish America:A Structural Analysis.” Hispanic American Historical Review 51:pp.110-116. Kirkpatrick, F. A. “Repartimiento-Encomienda.” Hispanic American HistoricalReview XIX: pp.373-379. Pastrana, Apolinar. “The Franciscans and the Evangelization of the Philippines(1578-1900).” Boletin Eclesiastico de Filipinas, 29, Jan-Feb 1965:pp.83-85. Quirk, Robert E. “Some Notes on a Controversial Controversy: Juan Gines deSepulveda and Natural Servitude.” Hispanic American Historical ReviewVol.XXXIV No.3 August 1954: 358. Ramirez, Susan S. “Encomienda.” Encyclopedia of Latin American History andCulture, Vol.2 Edited by Barbara A. Tenenbaum. New York: MacmillanLibrary Reference, 1996. Schwaller, John F. “Patronato Real”. Encyclopedia in Latin American History andCulture, Vol.4. Edited by Barbara a. Tenenbaum. New York: MacmillanLibrary Reference, 1996. Scott. William Henry. “Why did Tupas betray Dagami?” Philippine Quarterly ofCulture and Society 14 (1986): p.24. Villaroel, Fidel. “The Church and the Philippine Referendum of 1599.” PhilippinianaSacra Vol.XXXV 2000: pp.89-128. Internet Source Hyperdictionary. http://www. hyperdictionary.com/dictionary/politics, accessedon 18 December 2004. Human Rights Watch World Report for Philippines, 2017 https://www.hrw.org/world-report/2017/country-chapters/philippines. General References Encyclopedia of Latin American History and Culture, Volume 1-5. Edited byBarbara A. Tenebaum. New York: Macmillan Library Reference, 1996. Kasaysayan: The Story of the Filipino People ,Vol. 3 The Spanish Conquest.Hongkong: Asia Publishing Company Limited, 1998. Unpublished Materials Cabezon, Antonio. An Introduction to Church and State Relations According toFrancisco Vitoria. Unpublished Thesis: University of Sto. Tomas, 1964. De la Costa, Horacio. Jurisdictional Conflicts in the Philippines During the XVIand the XVII Centuries. Harvard: Unpublished Dissertation, 1951.
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Gofur, Nanda Rachmad Putra Gofur, Aisyah Rachmadani Putri Gofur Gofur, Soesil aningtyas, Rizki Nur Rachman Putra Gofur, Mega Kahdina, and Hernalia Martadila Putri. "Genes associated as risk factor Morbus Hansen’s disease: A review article." Journal of Clinical Images and Medical Case Reports, March 6, 2021. http://dx.doi.org/10.52768/2766-7820/1021.

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Introduction: Morbus Hansen is a chronic infectious disease caused by the bacteria Mycobacterium leprae and Mycobacterium lepromatosis. Morbus Hansen is still a health problem in endemic areas, such as Africa, Southeast Asia and Latin America. Morbus Hansen (MH) is named after the founder of this disease in the 19th century, a doctor from Norway named Gerhard Henrik Armauer Hansen. An increase in the incidence of Morbus Hansen occurs in people with household contacts with Morbus Hansen sufferers. This manuscript review which gene had a role in morbus Hansen disease. Discussion: Morbus Hansen disease is characterized by a granulomatous inflammatory process in the peripheral nerves and mucosa of the upper respiratory tract and lesions on the skin are the main clinical signs that can be seen. Mycobacterium leprae is intracellular, namely in reticuloendothelial cells, for example macrophages and on peripheral nerves, namely on the Schwan cell. Mycobacterium leprae infection can also attack the eye and testes. Risk factors for the occurrence of Morbus Hansen disease include: living in an endemic area of Morbus Hansen, low socio-economic conditions, such as poor living facilities, contaminated water, poor nutrition, other diseases that can reduce the body’s immune system, contact with morbus Hansen patient’s and gene risk. Several genes have been studied and are associated with individual susceptibility to infection with the bacteria Mycobacterium leprae. Conclusion: Several genes are associated with individual susceptibility to infection with Morbus Hansen Disease. Recent studies have this gene could defects in the cellular immune response more vulrenerable to infection with bacteria Mycobacterium leprae. These defect came from genes that are thought to be associated with Morbus Hansen disease. Furthermore, research studies must confirm these genes.
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Allatson, Paul, and Jeff Browitt. "Introducing Hyperworld(s): Language, Culture, and History in the Latin American world(s)." PORTAL Journal of Multidisciplinary International Studies 5, no. 1 (February 6, 2008). http://dx.doi.org/10.5130/portal.v5i1.654.

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This introduction to the January 2008 special edition of PORTAL engages with the processes by which, in the early 21st century—an information age of hypertechnology, post-nationalism, post-Fordism, and dominating transnational media—culture and economy have become fused, and globalizations tend towards the mercantilization, commodification, and privatization of human experience. We recognize that access to the technologies of globalizations is uneven. Although cyberspace and other hypertechnologies have become an integral part of workspaces, and of the domestic space in most households, across Western industrialized societies, and for the middle and upper-classes everywhere, this is not a reality for most people in the world, including the Latin American underclasses, the majority of the continent’s population. But we also agree with pundits who note how that limited access has not prevented a ‘techno-virtual spillover’ into the historical-material world. More and more people are increasingly touched by the techno-virtual realm and its logics, with a resultant transformation of global imaginaries in response to, for instance, the global spread of privatised entertainment and news via TV, satellites and the internet, and virtualized military operations (wars on terror, drugs, and rogue regimes). Under these hyperworldizing conditions, we asked, how might we talk about language, culture and history in Latin America, especially since language has an obvious, enduring importance as a tool for communication, and as the means to define culture and give narrative shape to our histories and power struggles? Our central term ‘hyperworld(s)’ presents us with numerous conceptual and epistemological challenges, not least because, whether unintended or not, it evokes cyberspace, thus gesturing toward either the seamless integration of physical and virtual reality, or its converse, a false opposition between the material and the virtual. The term may also evoke unresolved contradictions between discourses of technophobia and technophilia and, by extension, lead to dichotomized readings of the age in terms of the limits to, and capacities for, political resistance. In our conception, however, hyperworld(s) is not contained by the term virtuality; it encompasses, exceeds, challenges, and devours it. The production of hyperworld(s), or hyperworldization, connotes acceleration and hyperactivity on social, economic and financial levels, the intensified commodification of human life, the time-space compression of communication and much cultural production, the re-ordering of social relations themselves over-determined by technology wedded to capitalist market values, and, as a result, the re-ordering of daily life, cultural expression, and political activism for individuals and communities across the planet. These processes and intensities mean that new modes of reading the interactive and contradictory discursive fragmentations of the current epoch are required. Thus, rather than regarding cyberspace simply as the technological hallmark or dominant trope of our epoch, we might make deeper sense of hyperworld(s)—the bracketed plural implying myriad intersecting worlds within ‘the’ world—by identifying interactive entry points into contemporary lived historical-material and imagined complexities in the Latin American world(s). This article has been cited in the following: Duarte Alonso, Abel, and Yi Liu. “Changing Visitor Perceptions of a Capital City: The Case of Wellington, New Zealand.” City Tourism: National Capital Perspectives, ed. Robert Maitland and Brent W. Richie. Wallingford, UK: CABI, 2010, 110-24.
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Provençal, Johanne. "Ghosts in Machines and a Snapshot of Scholarly Journal Publishing in Canada." M/C Journal 11, no. 4 (July 1, 2008). http://dx.doi.org/10.5204/mcj.45.

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The ideas put forth here do not fit perfectly or entirely into the genre and form of what has established itself as the scholarly journal article. What is put forth, instead, is a juxtaposition of lines of thinking about the scholarly and popular in publishing, past, present and future. As such it may indeed be quite appropriate to the occasion and the questions raised in the call for papers for this special issue of M/C Journal. The ideas put forth here are intended as pieces of an ever-changing puzzle of the making public of scholarship, which, I hope, may in some way fit with both the work of others in this special issue and in the discourse more broadly. The first line of thinking presented takes the form of an historical overview of publishing as context to consider a second line of thinking about the current status and future of publishing. The historical context serves as reminder (and cause for celebration) that publishing has not yet perished, contrary to continued doomsday sooth-saying that has come with each new medium since the advent of print. Instead, publishing has continued to transform and it is precisely the transformation of print, print culture and reading publics that are the focus of this article, in particular, in relation to the question of the boundaries between the scholarly and the popular. What follows is a juxtaposition that is part of an investigation in progress. Presented first, therefore, is a mapping of shifts in print culture from the time of Gutenberg to the twentieth century; second, is a contemporary snapshot of the editorial mandates of more than one hundred member journals of the Canadian Association of Learned Journals (CALJ). What such juxtaposition is able to reveal is open to interpretation, of course. And indeed, as I proceed in my investigation of publishing past, present and future, my interpretations are many. The juxtaposition raises a number of issues: of communities of readers and the cultures of reading publics; of privileged and marginalised texts (as well as their authors and their readers); of access and reach (whether in terms of what is quantifiable or in a much more subtle but equally important sense). In Canada, at present, these issues are also intertwined with changes to research funding policies and some attention is given at the end of this article to the Social Sciences and Humanities Research Council (SSHRC) of Canada and its recent/current shift in funding policy. Curiously, current shifts in funding policies, considered alongside an historical overview of publishing, would suggest that although publishing continues to transform, at the same time, as they say, plus ça change, plus c’est la même chose. Republics of Letters and Ghosts in Machines Republics of Letters that formed after the advent of the printing press can be conjured up as distant and almost mythical communities of elite literates, ghosts almost lost in a Gutenberg galaxy that today encompasses (and is embodied in) schools, bookshelves, and digital archives in many places across the globe. Conjuring up ghosts of histories past seems always to reveal ironies, and indeed some of the most interesting ironies of the Gutenberg galaxy involve McLuhanesque reversals or, if not full reversals, then in the least some notably sharp turns. There is a need to define some boundaries (and terms) in the framing of the tracing that follows. Given that the time frame in question spans more than five hundred years (from the advent of Gutenberg’s printing press in the fifteenth century to the turn of the 21st century), the tracing must necessarily be done in broad strokes. With regard to what is meant by the “making public of scholarship” in this paper, by “making public” I refer to accounts historians have given in their attempts to reconstruct a history of what was published either in the periodical press or in books. With regard to scholarship (and the making public of it), as with many things in the history of publishing (or any history), this means different things in different times and in different places. The changing meanings of what can be termed “scholarship” and where and how it historically has been made public are the cornerstones on which this article (and a history of the making public of scholarship) turn. The structure of this paper is loosely chronological and is limited to the print cultures and reading publics in France, Britain, and what would eventually be called the US and Canada, and what follows here is an overview of changes in how scholarly and popular texts and publics are variously defined over the course of history. The Construction of Reading Publics and Print Culture In any consideration of “print culture” and reading publics, historical or contemporary, there are two guiding principles that historians suggest should be kept in mind, and, though these may seem self-evident, they are worth stating explicitly (perhaps precisely because they seem self-evident). The first is a reminder from Adrian Johns that “the very identity of print itself has had to be made” (2 italics in original). Just as the identity of print cultures are made, similarly, a history of reading publics and their identities are made, by looking to and interpreting such variables as numbers and genres of titles published and circulated, dates and locations of collections, and information on readers’ experiences of texts. Elizabeth Eisenstein offers a reminder of the “widely varying circumstances” (92) of the print revolution and an explicit acknowledgement of such circumstances provides the second, seemingly self-evident guiding principle: that the construction of reading publics and print culture must not only be understood as constructed, but also that such constructions ought not be understood as uniform. The purpose of the reconstructions of print cultures and reading publics presented here, therefore, is not to arrive at final conclusions, but rather to identify patterns that prove useful in better understanding the current status (and possible future) of publishing. The Fifteenth and Sixteenth Centuries—Boom, then Busted by State and Church In search of what could be termed “scholarship” following the mid-fifteenth century boom of the early days of print, given the ecclesiastical and state censorship in Britain and France and the popularity of religious texts of the 15th and 16th centuries, arguably the closest to “scholarship” that we can come is through the influence of the Italian Renaissance and the revival and translation (into Latin, and to a far lesser extent, vernacular languages) of the classics and indeed the influence of the Italian Renaissance on the “print revolution” is widely recognised by historians. Historians also recognise, however, that it was not long until “the supply of unpublished texts dried up…[yet for authors] to sell the fruits of their intellect—was not yet common practice before the late 16th century” (Febvre and Martin 160). Although this reference is to the book trade in France, in Britain, and in the regions to become the US and Canada, reading of “pious texts” was similarly predominant in the early days of print. Yet, the humanist shift throughout the 16th century is evidenced by titles produced in Paris in the first century of print: in 1501, in a total of 88 works, 53 can be categorised as religious, with 25 categorised as Latin, Greek, or Humanist authors; as compared to titles produced in 1549, in a total of 332 titles, 56 can be categorised as religious with 204 categorised as Latin, Greek, or Humanist authors (Febvre and Martin 264). The Seventeenth Century—Changes in the Political and Print Landscape In the 17th century, printers discovered that their chances of profitability (and survival) could be improved by targeting and developing a popular readership through the periodical press (its very periodicity and relative low cost both contributed to its accessibility by popular publics) in Europe as well as in North America. It is worthwhile to note, however, that “to the end of the seventeenth century, both literacy and leisure were virtually confined to scholars and ‘gentlemen’” (Steinberg 119) particularly where books were concerned and although literacy rates were still low, through the “exceptionally literate villager” there formed “hearing publics” who would have printed texts read to them (Eisenstein 93). For the literate members of the public interested not only in improving their social positions through learning, but also with intellectual (or spiritual or existential) curiosity piqued by forbidden books, it is not surprising that Descartes “wrote in French to a ‘lay audience … open to new ideas’” (Jacob 41). The 17th century also saw the publication of the first scholarly journals. There is a tension that becomes evident in the seventeenth century that can be seen as a tension characteristic of print culture, past and present: on the one hand, the housing of scholarship in scholarly journals as a genre distinct from the genre of the popular periodicals can be interpreted as a continued pattern of (elitist) divide in publics (as seen earlier between the oral and the written word, between Latin and the vernacular, between classic texts and popular texts); while, on the other hand, some thinkers/scholars of the day had an interest in reaching a wider audience, as printers always had, which led to the construction and fragmentation of audiences (whether the printer’s market for his goods or the scholar’s marketplace of ideas). The Eighteenth Century—Republics of Letters Become Concrete and Visible The 18th century saw ever-increasing literacy rates, early copyright legislation (Statute of Anne in 1709), improved printing technology, and ironically (or perhaps on the contrary, quite predictably) severe censorship that in effect led to an increased demand for forbidden books and a vibrant and international underground book trade (Darnton and Roche 138). Alongside a growing book trade, “the pulpit was ultimately displaced by the periodical press” (Eisenstein 94), which had become an “established institution” (Steinberg 125). One history of the periodical press in France finds that the number of periodicals (to remain in publication for three or more years) available to the reading public in 1745 numbered 15, whereas in 1785 this increased to 82 (Censer 7). With regard to scholarly periodicals, another study shows that between 1790 and 1800 there were 640 scientific-technological periodicals being published in Europe (Kronick 1961). Across the Atlantic, earlier difficulties in cultivating intellectual life—such as haphazard transatlantic exchange and limited institutions for learning—began to give way to a “republic of letters” that was “visible and concrete” (Hall 417). The Nineteenth Century—A Second Boom and the Rise of the Periodical Press By the turn of the 19th century, visible and concrete republics of letters become evident on both sides of the Atlantic in the boom in book publishing and in the periodical press, scholarly and popular. State and church controls on printing/publishing had given way to the press as the “fourth estate” or a free press as powerful force. The legislation of public education brought increased literacy rates among members of successive generations. One study of literacy rates in Britain, for example, shows that in the period from 1840–1870 literacy rates increased by 35–70 per cent; then from 1870–1900, literacy increased by 78–261 per cent (Mitch 76). Further, with the growth and changes in universities, “history, languages and literature and, above all, the sciences, became an established part of higher education for the first time,” which translated into growing markets for book publishers (Feather 117). Similarly the periodical press reached ever-increasing and numerous reading publics: one estimate of the increase finds the publication of nine hundred journals in 1800 jumping to almost sixty thousand in 1901 (Brodman, cited in Kronick 127). Further, the important role of the periodical press in developing communities of readers was recognised by publishers, editors and authors of the time, something equally recognised by present-day historians describing the “generic mélange of the periodical … [that] particularly lent itself to the interpenetration of language and ideas…[and] the verbal and conceptual interconnectedness of science, politics, theology, and literature” (Dawson, Noakes and Topham 30). Scientists recognised popular periodicals as “important platforms for addressing a non-specialist but culturally powerful public … [they were seen as public] performances [that] fulfilled important functions in making the claims of science heard among the ruling élite” (Dawson et al. 11). By contrast, however, the scholarly journals of the time, while also increasing in number, were becoming increasingly specialised along the same disciplinary boundaries being established in the universities, fulfilling a very different function of forming scholarly and discipline-specific discourse communities through public (published) performances of a very different nature. The Twentieth Century—The Tension Between Niche Publics and Mass Publics The long-existing tension in print culture between the differentiation of reading publics on the one hand, and the reach to ever-expanding reading publics on the other, in the twentieth century becomes a tension between what have been termed “niche-marketing” and “mass marketing,” between niche publics and mass publics. What this meant for the making public of scholarship was that the divides between discipline-specific discourse communities (and their corresponding genres) became more firmly established and yet, within each discipline, there was further fragmentation and specialisation. The niche-mass tension also meant that although in earlier print culture, “the lines of demarcation between men of science, men of letters, and scientific popularizers were far from clear, and were constantly being renegotiated” (Dawson et al 28), with the increasing professionalisation of academic work (and careers), lines of demarcation became firmly drawn between scholarly and popular titles and authors, as well as readers, who were described as “men of science,” as “educated men,” or as “casual observers” (Klancher 90). The question remains, however, as one historian of science asks, “To whom did the reading public go in order to learn about the ultimate meaning of modern science, the professionals or the popularizers?” (Lightman 191). By whom and for whom, where and how scholarship has historically been made public, are questions worthy of consideration if contemporary scholars are to better understand the current status (and possible future) for the making public of scholarship. A Snapshot of Scholarly Journals in Canada and Current Changes in Funding Policies The here and now of scholarly journal publishing in Canada (a growing, but relatively modest scholarly journal community, compared to the number of scholarly journals published in Europe and the US) serves as an interesting microcosm through which to consider how scholarly journal publishing has evolved since the early days of print. What follows here is an overview of the membership of the Canadian Association of Learned Journals (CALJ), in particular: (1) their target readers as identifiable from their editorial mandates; (2) their print/online/open-access policies; and (3) their publishers (all information gathered from the CALJ website, http://www.calj-acrs.ca/). Analysis of the collected data for the 100 member journals of CALJ (English, French and bilingual journals) with available information on the CALJ website is presented in Table 1 (below). A few observations are noteworthy: (1) in terms of readers, although all 100 journals identify a scholarly audience as their target readership, more than 40% of the journal also identify practitioners, policy-makers, or general readers as members of their target audience; (2) more than 25% of the journals publish online as well as or instead of print editions; and (3) almost all journals are published either by a Canadian university or, in one case, a college (60%) or a scholarly or professional society (31%). Table 1: Target Readership, Publishing Model and Publishers, CALJ Members (N=100) Journals with identifiable scholarly target readership 100 Journals with other identifiable target readership: practitioner 35 Journals with other identifiable target readership: general readers 18 Journals with other identifiable target readership: policy-makers/government 10 Total journals with identifiable target readership other than scholarly 43 Journals publishing in print only 56 Journals publishing in print and online 24 Journals publishing in print, online and open access 16 Journals publishing online only and open access 4 Journals published through a Canadian university press, faculty or department 60 Journals published by a scholarly or professional society 31 Journals published by a research institute 5 Journals published by the private sector 4 In the context of the historical overview presented earlier, this data raises a number of questions. The number of journals with target audiences either within or beyond the academy raises issues akin to the situation in the early days of print, when published works were primarily in Latin, with only 22 per cent in vernacular languages (Febvre and Martin 256), thereby strongly limiting access and reach to diverse audiences until the 17th century when Latin declined as the international language (Febvre and Martin 275) and there is a parallel to scholarly journal publishing and their changing readership(s). Diversity in audiences gradually developed in the early days of print, as Febvre and Martin (263) show by comparing the number of churchmen and lawyers with library collections in Paris: from 1480–1500 one lawyer and 24 churchmen had library collections, compared to 1551–1600, when 71 lawyers and 21 churchmen had library collections. Although the distinctions between present-day target audiences of Canadian scholarly journals (shown in Table 1, above) and 16th-century churchmen or lawyers no doubt are considerable, again there is a parallel with regard to changes in reading audiences. Similarly, the 18th-century increase in literacy rates, education, and technological advances finds a parallel in contemporary questions of computer literacy and access to scholarship (see Willinsky, “How,” Access, “Altering,” and If Only). Print culture historians and historians of science, as noted above, recognise that historically, while scholarly periodicals have increasingly specialised and popular periodicals have served as “important platforms for addressing a non-specialist but culturally powerful public…[and] fulfill[ing] important functions in making the claims of science heard among the ruling élite” (Dawson 11), there is adrift in current policies changes (and in the CALJ data above) a blurring of boundaries that harkens back to earlier days of print culture. As Adrian John reminded us earlier, “the very identity of print itself has had to be made” (2, italics in original) and the same applies to identities or cultures of print and the members of that culture: namely, the readers, the audience. The identities of the readers of scholarship are being made and re-made, as editorial mandates extend the scope of journals beyond strict, academic disciplinary boundaries and as increasing numbers of journals publish online (and open access). In Canada, changes in scholarly journal funding by the Social Sciences and Humanities Research Council (SSHRC) of Canada (as well as changes in SSHRC funding for research more generally) place increasing focus on impact factors (an international trend) as well as increased attention on the public benefits and value of social sciences and humanities research and scholarship (see SSHRC 2004, 2005, 2006). There is much debate in the scholarly community in Canada about the implications and possibilities of the direction of the changing funding policies, not least among members of the scholarly journal community. As noted in the table above, most scholarly journal publishers in Canada are independently published, which brings advantages of autonomy but also the disadvantage of very limited budgets and there is a great deal of concern about the future of the journals, about their survival amidst the current changes. Although the future is uncertain, it is perhaps worthwhile to be reminded once again that contrary to doomsday sooth-saying that has come time and time again, publishing has not perished, but rather it has continued to transform. I am inclined against making normative statements about what the future of publishing should be, but, looking at the accounts historians have given of the past and looking at the current publishing community I have come to know in my work in publishing, I am confident that the resourcefulness and commitment of the publishing community shall prevail and, indeed, there appears to be a good deal of promise in the transformation of scholarly journals in the ways they reach their audiences and in what reaches those audiences. Perhaps, as is suggested by the Canadian Centre for Studies in Publishing (CCSP), the future is one of “inventing publishing.” References Canadian Association of Learned Journals. Member Database. 10 June 2008 ‹http://www.calj-acrs.ca/>. Canadian Centre for Studies in Publishing. 10 June 2008. ‹http://www.ccsp.sfu.ca/>. Censer, Jack. The French Press in the Age of Enlightenment. London: Routledge, 1994. Darnton, Robert, Estienne Roche. Revolution in Print: The Press in France, 1775–1800. Berkeley: U of California P, 1989. Dawson, Gowan, Richard Noakes, and Jonathan Topham. Introduction. Science in the Nineteenth-century Periodical: Reading the Magazine of Nature. Ed. Geoffrey Cantor, Gowan Dawson, Richard Noakes, and Jonathan Topham. Cambridge: Cambridge UP, 2004. 1–37. Eisenstein, Elizabeth. The Printing Revolution in Early Modern Europe. Cambridge: Cambridge UP, 1983 Feather, John. A History of British Publishing. New York: Routledge, 2006. Febvre, Lucien, and Henri-Jean Martin. The Coming of the Book: The Impact of Printing 1450–1800. London: N.L.B., 1979. Jacob, Margaret. Scientific Culture and the Making of the Industrial West. New York: Oxford UP, 1997. Johns, Adrian. The Nature of the Book: Print and Knowledge in the Making. Chicago: U of Chicago P, 1998. Hall, David, and Hugh Armory. The Colonial Book in the Atlantic World. Cambridge: Cambridge UP, 2000. Klancher, Jon. The Making of English Reading Audiences. Madison: U of Wisconsin P, 1987. Kronick, David. A History of Scientific and Technical Periodicals: The Origins and Development of the Scientific and Technological Press, 1665–1790. New York: Scarecrow Press, 1961. ---. "Devant le deluge" and Other Essays on Early Modern Scientific Communication. Lanham: Scarecrow Press, 2004. Lightman, Bernard. Victorian Science in Context. Chicago: U of Chicago P, 1997. Mitch, David. The Rise of Popular Literacy in Victorian England: The Influence of Private choice and Public Policy. Philadelphia: U of Pennsylvania P, 1991. Social Sciences and Humanities Research Council. Granting Council to Knowledge Council: Renewing the Social Sciences and Humanities in Canada, Volume 1, 2004. Social Sciences and Humanities Research Council. Granting Council to Knowledge Council: Renewing the Social Sciences and Humanities in Canada, Volume 3, 2005. Social Sciences and Humanities Research Council. Moving Forward As a Knowledge Council: Canada’s Place in a Competitive World. 2006. Steinberg, Sigfrid. Five Hundred Years of Printing. London: Oak Knoll Press, 1996. Willinsky, John. “How to be More of a Public Intellectual by Making your Intellectual Work More Public.” Journal of Curriculum and Pedagogy 3.1 (2006): 92–95. ---. The Access Principle: The Case for Open Access to Research and Scholarship. Cambridge, MA: MIT Press, 2006. ---. “Altering the Material Conditions of Access to the Humanities.” Ed. Peter Trifonas and Michael Peters. Deconstructing Derrida: Tasks for the New Humanities. London: Palgrave Macmillan, 2005. 118–36. ---. If Only We Knew: Increasing the Public Value of Social-Science Research. New York: Routledge, 2000.
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Brien, Donna Lee, and Jill Adams. "Coffee: A Cultural and Media Focussed Approach." M/C Journal 15, no. 2 (May 7, 2012). http://dx.doi.org/10.5204/mcj.505.

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By the 12th century, coffee was extensively cultivated in Yemen, and qawha and cahveh, hot beverages made from roast and ground coffee beans, became popular in the Islamic world over the next 300 years. Commercial production of coffee outside Yemen started in Sri Lanka in the 1660s, Java in the 1700s, and Latin America in 1715, and this production has associations with histories of colonial expansion and slavery. Introduced to Europe in the 17th century, coffee was described by Robert Burton in the section of his 1628 Anatomy of Melancholy devoted to medicines as “an intoxicant, a euphoric, a social and physical stimulant, and a digestive aid” (quoted in Weinberg and Bealer xii). Today, more than 400 billion cups of coffee are consumed each year. Coffee is also an ingredient in a series of iconic dishes such as tiramisu and, with chocolate, makes up the classic mocha mix. Coffee production is widespread in tropical and sub-tropical countries and it is the second largest traded world commodity; second only to oil and petroleum. The World Bank estimates that more than 500 million people throughout the world depend on coffee for their livelihoods, and 25 million of these are coffee farmers. Unfortunately, these farmers typically live and work in substandard conditions and receive only a small percentage of the final price that their coffee is sold for. The majority of coffee farmers are women and they face additional challenges, frequently suffering from abuse, neglect, and poverty, and unable to gain economic, social, or political power in either their family’s coffee businesses or their communities. Some farm coffee under enslaved or indentured conditions, although Fair Trade regimes are offering some lessening of inequalities. At the opposite end of the scale, a small, but growing, number of high-end producers market gourmet sustainable coffee from small-scale, environmentally-aware farming operations. For many in the West today, however, coffee is not about the facts of its production; coffee is all about consumption, and is now interwoven into our contemporary cultural and social habits. Caffeine, found in the leaves, seeds, and fruit of the coffee tree, is an addictive psychoactive substance, but has overcome resistance and disapproval around the world and is now unregulated and freely available, without licence. Our gastronomic sophistication is reflected in which coffee, brewing method, and location of consumption is chosen; our fast-paced lifestyles in the range of coffee-to-go options we have; and our capitalist orientation in the business opportunities this popularity has offered to small entrepreneurs and multinational franchise chains alike. Cafés and the meeting, mingling, discussions, and relaxing that occur there while drinking coffee, are a contemporary topic of reflection and scholarship, as are the similarities and differences between the contemporary café and its earlier incarnations, including, of course, the Enlightenment coffee house. As may be expected from a commodity which has such a place in our lives, coffee is represented in many ways in the media—including in advertising, movies, novels, poetry, songs and, of course, in culinary writing, including cookbooks, magazines, and newspapers. There are specialist journals and popular serials dedicated to expounding and exploring the fine grain detail of its production and consumption, and food historians have written multiple biographies of coffee’s place in our world. So ubiquitous, indeed, is coffee, that as a named colour, it popularly features in fashion, interior design, home wares, and other products. This issue of M/C Journal invited contributors to consider coffee from any relevant angle that makes a contribution to our understanding of coffee and its place in culture and/or the media, and the result is a valuable array of illuminating articles from a diverse range of perspectives. It is for this reason that we chose an image of coffee cherries for the front cover of this issue. Co-editor Jill Adams has worked in the coffee industry for over ten years and has a superb collection of coffee images that ranges from farmers in Papua New Guinea to artfully shot compositions of antique coffee brewing equipment. In making our choice, however, we felt that Spencer Franks’s image of ripe coffee cherries at the Skybury Coffee Plantation in Far North Queensland, Australia, encapsulates the “fruitful” nature of the response to our call for articles for this issue. While most are familiar, moreover, with the dark, glossy appearance and other sensual qualities of roasted coffee beans, fewer have any occasion to contemplate just how lovely the coffee tree is as a plant. Each author has utilised the idea of “coffee” as a powerful springboard into a fascinating range of areas, showing just how inseparable coffee is from so many parts of our daily lives—even scholarly enquiry. In our first feature article, Susie Khamis profiles and interrogates the Nespresso brand, and how it points to the growing individualisation of coffee consumption, whereby the social aspect of cafés gives way to a more self-centred consumer experience. This feature valuably contrasts the way Starbucks has marketed itself as a social hub with the Nespresso boutique experience—which as Khamis explains—is not a café, but rather a club, a trademarked, branded space, predicated on highly knowledgeable and, therefore, privileged patrons. Coffee drinking is also associated with both sobriety and hangover cures, with cigarettes, late nights, and music. Our second feature, by Jon Stewart, looks at how coffee has become interwoven into our lives and imaginations through the music that we listen to—from jazz to blues to musical theatre numbers. It examines the influence of coffee as subject for performers and songwriters in three areas: coffee and courtship rituals, the stimulating effects of caffeine, and the politics of coffee consumption, claiming that coffee carries a cultural and musicological significance comparable to that of other drugs and ubiquitous consumer goods that are often more readily associated with popular music. Diana Noyce looks at the short-lived temperance movement in Australia, the opulent architecture of the coffee palaces built in that era, what was actually drunk in them, and their fates as the temperance movement passed into history. Emma Felton lyrically investigates how “going for a coffee” is less about coffee and more about how we connect with others in a mobile world, when flexible work hours are increasingly the norm and more people are living alone than any other period in history. Felton also introducess a theme that other writers also engage with: that the café also plays a role in the development of civil discourse and civility, and plays an important role in the development of cosmopolitan civil societies. Ireland-based Máirtín Mac Con Iomaire surveys Dublin—that tea drinking city—and both the history of coffee houses and the enduring coffee culture it possesses; a coffee culture that seems well assured through a remarkable win for Ireland in the 2008 World Barista Championships. China has also always been strongly associated with tea drinking but Adel Wang introduces readers to the emerging, and unique, café and coffee culture of that country, as well as some of the proprietors who are bringing about this cultural change. Australia, also once a significant consumer of tea, shifted to a preference for coffee over a twenty year period that began with the arrival of American Servicemen in Australia during World War II. Jill Adams looks at the rise of coffee during that time, and the efforts made by the tea industry to halt its market growth. These strong links between tea and coffee are reflected in Duncan Barnes, Danielle Fusco, and Lelia Green’s thought-provoking study of how coffee is marketed in Bangladesh, another tea drinking country. Ray Oldenberg’s influential concept of the “third place” is referred to by many authors in this collection, but Anthony McCosker and Rowan Wilken focus on this idea. By using a study of how Polish composer, Krzysztof Penderecki, worked in his local café from 9 in the morning to noon each day, this article explores the interrelationship of café space, communication, creativity, and materialism. Donna Lee Brien brings us back to the domestic space with her article on how the popular media of cookery books and magazines portray how coffee was used in Australian cooking at mid-century, in the process, tracing how tiramisu triumphed over the trifle. By exploring the currently fashionable practice of “direct trade” between roasters and coffee growers Sophie Sunderland offers a fresh perspective on coffee production by powerfully arguing that feeling (“affect”) is central to the way in which coffee is produced, represented and consumed in Western mass culture. Sunderland thus brings the issue full circle and back to Khamis’s discussion, for there is much feeling mobilised in the marketing of Nespresso. We would like to thank all the contributors and our generous and erudite peer reviewers for their work in the process of putting together this issue. We would also like to specially thank Spencer Franks for permission to use his image of coffee cherries as our cover image. We would lastly like to thank you the general editors of M/C Journal for selecting this theme for the journal this year.References Oldenburg, Ray, ed. Celebrating the Third Place: Inspiring Stories about the “Great Good Places” At the Heart of Our Communities. New York: Marlowe & Company 2001.Weinberg, Bennett Alan, and Bonnie K Bealer. The World of Caffeine. New York and London: Routledge, 2001.
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Noyce, Diana Christine. "Coffee Palaces in Australia: A Pub with No Beer." M/C Journal 15, no. 2 (May 2, 2012). http://dx.doi.org/10.5204/mcj.464.

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The term “coffee palace” was primarily used in Australia to describe the temperance hotels that were built in the last decades of the 19th century, although there are references to the term also being used to a lesser extent in the United Kingdom (Denby 174). Built in response to the worldwide temperance movement, which reached its pinnacle in the 1880s in Australia, coffee palaces were hotels that did not serve alcohol. This was a unique time in Australia’s architectural development as the economic boom fuelled by the gold rush in the 1850s, and the demand for ostentatious display that gathered momentum during the following years, afforded the use of richly ornamental High Victorian architecture and resulted in very majestic structures; hence the term “palace” (Freeland 121). The often multi-storied coffee palaces were found in every capital city as well as regional areas such as Geelong and Broken Hill, and locales as remote as Maria Island on the east coast of Tasmania. Presented as upholding family values and discouraging drunkenness, the coffee palaces were most popular in seaside resorts such as Barwon Heads in Victoria, where they catered to families. Coffee palaces were also constructed on a grand scale to provide accommodation for international and interstate visitors attending the international exhibitions held in Sydney (1879) and Melbourne (1880 and 1888). While the temperance movement lasted well over 100 years, the life of coffee palaces was relatively short-lived. Nevertheless, coffee palaces were very much part of Australia’s cultural landscape. In this article, I examine the rise and demise of coffee palaces associated with the temperance movement and argue that coffee palaces established in the name of abstinence were modelled on the coffee houses that spread throughout Europe and North America in the 17th and 18th centuries during the Enlightenment—a time when the human mind could be said to have been liberated from inebriation and the dogmatic state of ignorance. The Temperance Movement At a time when newspapers are full of lurid stories about binge-drinking and the alleged ill-effects of the liberalisation of licensing laws, as well as concerns over the growing trend of marketing easy-to-drink products (such as the so-called “alcopops”) to teenagers, it is difficult to think of a period when the total suppression of the alcohol trade was seriously debated in Australia. The cause of temperance has almost completely vanished from view, yet for well over a century—from 1830 to the outbreak of the Second World War—the control or even total abolition of the liquor trade was a major political issue—one that split the country, brought thousands onto the streets in demonstrations, and influenced the outcome of elections. Between 1911 and 1925 referenda to either limit or prohibit the sale of alcohol were held in most States. While moves to bring about abolition failed, Fitzgerald notes that almost one in three Australian voters expressed their support for prohibition of alcohol in their State (145). Today, the temperance movement’s platform has largely been forgotten, killed off by the practical example of the United States, where prohibition of the legal sale of alcohol served only to hand control of the liquor traffic to organised crime. Coffee Houses and the Enlightenment Although tea has long been considered the beverage of sobriety, it was coffee that came to be regarded as the very antithesis of alcohol. When the first coffee house opened in London in the early 1650s, customers were bewildered by this strange new drink from the Middle East—hot, bitter, and black as soot. But those who tried coffee were, reports Ellis, soon won over, and coffee houses were opened across London, Oxford, and Cambridge and, in the following decades, Europe and North America. Tea, equally exotic, entered the English market slightly later than coffee (in 1664), but was more expensive and remained a rarity long after coffee had become ubiquitous in London (Ellis 123-24). The impact of the introduction of coffee into Europe during the seventeenth century was particularly noticeable since the most common beverages of the time, even at breakfast, were weak “small beer” and wine. Both were safer to drink than water, which was liable to be contaminated. Coffee, like beer, was made using boiled water and, therefore, provided a new and safe alternative to alcoholic drinks. There was also the added benefit that those who drank coffee instead of alcohol began the day alert rather than mildly inebriated (Standage 135). It was also thought that coffee had a stimulating effect upon the “nervous system,” so much so that the French called coffee une boisson intellectuelle (an intellectual beverage), because of its stimulating effect on the brain (Muskett 71). In Oxford, the British called their coffee houses “penny universities,” a penny then being the price of a cup of coffee (Standage 158). Coffee houses were, moreover, more than places that sold coffee. Unlike other institutions of the period, rank and birth had no place (Ellis 59). The coffee house became the centre of urban life, creating a distinctive social culture by treating all customers as equals. Egalitarianism, however, did not extend to women—at least not in London. Around its egalitarian (but male) tables, merchants discussed and conducted business, writers and poets held discussions, scientists demonstrated experiments, and philosophers deliberated ideas and reforms. For the price of a cup (or “dish” as it was then known) of coffee, a man could read the latest pamphlets and newsletters, chat with other patrons, strike business deals, keep up with the latest political gossip, find out what other people thought of a new book, or take part in literary or philosophical discussions. Like today’s Internet, Twitter, and Facebook, Europe’s coffee houses functioned as an information network where ideas circulated and spread from coffee house to coffee house. In this way, drinking coffee in the coffee house became a metaphor for people getting together to share ideas in a sober environment, a concept that remains today. According to Standage, this information network fuelled the Enlightenment (133), prompting an explosion of creativity. Coffee houses provided an entirely new environment for political, financial, scientific, and literary change, as people gathered, discussed, and debated issues within their walls. Entrepreneurs and scientists teamed up to form companies to exploit new inventions and discoveries in manufacturing and mining, paving the way for the Industrial Revolution (Standage 163). The stock market and insurance companies also had their birth in the coffee house. As a result, coffee was seen to be the epitome of modernity and progress and, as such, was the ideal beverage for the Age of Reason. By the 19th century, however, the era of coffee houses had passed. Most of them had evolved into exclusive men’s clubs, each geared towards a certain segment of society. Tea was now more affordable and fashionable, and teahouses, which drew clientele from both sexes, began to grow in popularity. Tea, however, had always been Australia’s most popular non-alcoholic drink. Tea (and coffee) along with other alien plants had been part of the cargo unloaded onto Australian shores with the First Fleet in 1788. Coffee, mainly from Brazil and Jamaica, remained a constant import but was taxed more heavily than tea and was, therefore, more expensive. Furthermore, tea was much easier to make than coffee. To brew tea, all that is needed is to add boiling water, coffee, in contrast, required roasting, grinding and brewing. According to Symons, until the 1930s, Australians were the largest consumers of tea in the world (19). In spite of this, and as coffee, since its introduction into Europe, was regarded as the antidote to alcohol, the temperance movement established coffee palaces. In the early 1870s in Britain, the temperance movement had revived the coffee house to provide an alternative to the gin taverns that were so attractive to the working classes of the Industrial Age (Clarke 5). Unlike the earlier coffee house, this revived incarnation provided accommodation and was open to men, women and children. “Cheap and wholesome food,” was available as well as reading rooms supplied with newspapers and periodicals, and games and smoking rooms (Clarke 20). In Australia, coffee palaces did not seek the working classes, as clientele: at least in the cities they were largely for the nouveau riche. Coffee Palaces The discovery of gold in 1851 changed the direction of the Australian economy. An investment boom followed, with an influx of foreign funds and English banks lending freely to colonial speculators. By the 1880s, the manufacturing and construction sectors of the economy boomed and land prices were highly inflated. Governments shared in the wealth and ploughed money into urban infrastructure, particularly railways. Spurred on by these positive economic conditions and the newly extended inter-colonial rail network, international exhibitions were held in both Sydney and Melbourne. To celebrate modern technology and design in an industrial age, international exhibitions were phenomena that had spread throughout Europe and much of the world from the mid-19th century. According to Davison, exhibitions were “integral to the culture of nineteenth century industrialising societies” (158). In particular, these exhibitions provided the colonies with an opportunity to demonstrate to the world their economic power and achievements in the sciences, the arts and education, as well as to promote their commerce and industry. Massive purpose-built buildings were constructed to house the exhibition halls. In Sydney, the Garden Palace was erected in the Botanic Gardens for the 1879 Exhibition (it burnt down in 1882). In Melbourne, the Royal Exhibition Building, now a World Heritage site, was built in the Carlton Gardens for the 1880 Exhibition and extended for the 1888 Centennial Exhibition. Accommodation was required for the some one million interstate and international visitors who were to pass through the gates of the Garden Palace in Sydney. To meet this need, the temperance movement, keen to provide alternative accommodation to licensed hotels, backed the establishment of Sydney’s coffee palaces. The Sydney Coffee Palace Hotel Company was formed in 1878 to operate and manage a number of coffee palaces constructed during the 1870s. These were designed to compete with hotels by “offering all the ordinary advantages of those establishments without the allurements of the drink” (Murdoch). Coffee palaces were much more than ordinary hotels—they were often multi-purpose or mixed-use buildings that included a large number of rooms for accommodation as well as ballrooms and other leisure facilities to attract people away from pubs. As the Australian Town and Country Journal reveals, their services included the supply of affordable, wholesome food, either in the form of regular meals or occasional refreshments, cooked in kitchens fitted with the latest in culinary accoutrements. These “culinary temples” also provided smoking rooms, chess and billiard rooms, and rooms where people could read books, periodicals and all the local and national papers for free (121). Similar to the coffee houses of the Enlightenment, the coffee palaces brought businessmen, artists, writers, engineers, and scientists attending the exhibitions together to eat and drink (non-alcoholic), socialise and conduct business. The Johnson’s Temperance Coffee Palace located in York Street in Sydney produced a practical guide for potential investors and businessmen titled International Exhibition Visitors Pocket Guide to Sydney. It included information on the location of government departments, educational institutions, hospitals, charitable organisations, and embassies, as well as a list of the tariffs on goods from food to opium (1–17). Women, particularly the Woman’s Christian Temperance Union (WCTU) were a formidable force in the temperance movement (intemperance was generally regarded as a male problem and, more specifically, a husband problem). Murdoch argues, however, that much of the success of the push to establish coffee palaces was due to male politicians with business interests, such as the one-time Victorian premiere James Munro. Considered a stern, moral church-going leader, Munro expanded the temperance movement into a fanatical force with extraordinary power, which is perhaps why the temperance movement had its greatest following in Victoria (Murdoch). Several prestigious hotels were constructed to provide accommodation for visitors to the international exhibitions in Melbourne. Munro was responsible for building many of the city’s coffee palaces, including the Victoria (1880) and the Federal Coffee Palace (1888) in Collins Street. After establishing the Grand Coffee Palace Company, Munro took over the Grand Hotel (now the Windsor) in 1886. Munro expanded the hotel to accommodate some of the two million visitors who were to attend the Centenary Exhibition, renamed it the Grand Coffee Palace, and ceremoniously burnt its liquor licence at the official opening (Murdoch). By 1888 there were more than 50 coffee palaces in the city of Melbourne alone and Munro held thousands of shares in coffee palaces, including those in Geelong and Broken Hill. With its opening planned to commemorate the centenary of the founding of Australia and the 1888 International Exhibition, the construction of the Federal Coffee Palace, one of the largest hotels in Australia, was perhaps the greatest monument to the temperance movement. Designed in the French Renaissance style, the façade was embellished with statues, griffins and Venus in a chariot drawn by four seahorses. The building was crowned with an iron-framed domed tower. New passenger elevators—first demonstrated at the Sydney Exhibition—allowed the building to soar to seven storeys. According to the Federal Coffee Palace Visitor’s Guide, which was presented to every visitor, there were three lifts for passengers and others for luggage. Bedrooms were located on the top five floors, while the stately ground and first floors contained majestic dining, lounge, sitting, smoking, writing, and billiard rooms. There were electric service bells, gaslights, and kitchens “fitted with the most approved inventions for aiding proficients [sic] in the culinary arts,” while the luxury brand Pears soap was used in the lavatories and bathrooms (16–17). In 1891, a spectacular financial crash brought the economic boom to an abrupt end. The British economy was in crisis and to meet the predicament, English banks withdrew their funds in Australia. There was a wholesale collapse of building companies, mortgage banks and other financial institutions during 1891 and 1892 and much of the banking system was halted during 1893 (Attard). Meanwhile, however, while the eastern States were in the economic doldrums, gold was discovered in 1892 at Coolgardie and Kalgoorlie in Western Australia and, within two years, the west of the continent was transformed. As gold poured back to the capital city of Perth, the long dormant settlement hurriedly caught up and began to emulate the rest of Australia, including the construction of ornately detailed coffee palaces (Freeman 130). By 1904, Perth had 20 coffee palaces. When the No. 2 Coffee Palace opened in Pitt Street, Sydney, in 1880, the Australian Town and Country Journal reported that coffee palaces were “not only fashionable, but appear to have acquired a permanent footing in Sydney” (121). The coffee palace era, however, was relatively short-lived. Driven more by reformist and economic zeal than by good business sense, many were in financial trouble when the 1890’s Depression hit. Leading figures in the temperance movement were also involved in land speculation and building societies and when these schemes collapsed, many, including Munro, were financially ruined. Many of the palaces closed or were forced to apply for liquor licences in order to stay afloat. Others developed another life after the temperance movement’s influence waned and the coffee palace fad faded, and many were later demolished to make way for more modern buildings. The Federal was licensed in 1923 and traded as the Federal Hotel until its demolition in 1973. The Victoria, however, did not succumb to a liquor licence until 1967. The Sydney Coffee Palace in Woolloomooloo became the Sydney Eye Hospital and, more recently, smart apartments. Some fine examples still survive as reminders of Australia’s social and cultural heritage. The Windsor in Melbourne’s Spring Street and the Broken Hill Hotel, a massive three-story iconic pub in the outback now called simply “The Palace,” are some examples. Tea remained the beverage of choice in Australia until the 1950s when the lifting of government controls on the importation of coffee and the influence of American foodways coincided with the arrival of espresso-loving immigrants. As Australians were introduced to the espresso machine, the short black, the cappuccino, and the café latte and (reminiscent of the Enlightenment), the post-war malaise was shed in favour of the energy and vigour of modernist thought and creativity, fuelled in at least a small part by caffeine and the emergent café culture (Teffer). Although the temperance movement’s attempt to provide an alternative to the ubiquitous pubs failed, coffee has now outstripped the consumption of tea and today’s café culture ensures that wherever coffee is consumed, there is the possibility of a continuation of the Enlightenment’s lively discussions, exchange of news, and dissemination of ideas and information in a sober environment. References Attard, Bernard. “The Economic History of Australia from 1788: An Introduction.” EH.net Encyclopedia. 5 Feb. (2012) ‹http://eh.net/encyclopedia/article/attard.australia›. Blainey, Anna. “The Prohibition and Total Abstinence Movement in Australia 1880–1910.” Food, Power and Community: Essays in the History of Food and Drink. Ed. Robert Dare. Adelaide: Wakefield Press, 1999. 142–52. Boyce, Francis Bertie. “Shall I Vote for No License?” An address delivered at the Convention of the Parramatta Branch of New South Wales Alliance, 3 September 1906. 3rd ed. Parramatta: New South Wales Alliance, 1907. Clarke, James Freeman. Coffee Houses and Coffee Palaces in England. Boston: George H. Ellis, 1882. “Coffee Palace, No. 2.” Australian Town and Country Journal. 17 Jul. 1880: 121. Davison, Graeme. “Festivals of Nationhood: The International Exhibitions.” Australian Cultural History. Eds. S. L. Goldberg and F. B. Smith. Cambridge: Cambridge UP, 1989. 158–77. Denby, Elaine. Grand Hotels: Reality and Illusion. London: Reaktion Books, 2002. Ellis, Markman. The Coffee House: A Cultural History. London: Weidenfeld & Nicolson, 2004. Federal Coffee Palace. The Federal Coffee Palace Visitors’ Guide to Melbourne, Its Suburbs, and Other Parts of the Colony of Victoria: Views of the Principal Public and Commercial Buildings in Melbourne, With a Bird’s Eye View of the City; and History of the Melbourne International Exhibition of 1880, etc. Melbourne: Federal Coffee House Company, 1888. Fitzgerald, Ross, and Trevor Jordan. Under the Influence: A History of Alcohol in Australia. Sydney: Harper Collins, 2009. Freeland, John. The Australian Pub. Melbourne: Sun Books, 1977. Johnson’s Temperance Coffee Palace. International Exhibition Visitors Pocket Guide to Sydney, Restaurant and Temperance Hotel. Sydney: Johnson’s Temperance Coffee Palace, 1879. Mitchell, Ann M. “Munro, James (1832–1908).” Australian Dictionary of Biography. Canberra: National Centre of Biography, Australian National U, 2006-12. 5 Feb. 2012 ‹http://adb.anu.edu.au/biography/munro-james-4271/text6905›. Murdoch, Sally. “Coffee Palaces.” Encyclopaedia of Melbourne. Eds. Andrew Brown-May and Shurlee Swain. 5 Feb. 2012 ‹http://www.emelbourne.net.au/biogs/EM00371b.htm›. Muskett, Philip E. The Art of Living in Australia. New South Wales: Kangaroo Press, 1987. Standage, Tom. A History of the World in 6 Glasses. New York: Walker & Company, 2005. Sydney Coffee Palace Hotel Company Limited. Memorandum of Association of the Sydney Coffee Palace Hotel Company, Ltd. Sydney: Samuel Edward Lees, 1879. Symons, Michael. One Continuous Picnic: A Gastronomic History of Australia. Melbourne: Melbourne UP, 2007. Teffer, Nicola. Coffee Customs. Exhibition Catalogue. Sydney: Customs House, 2005.
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42

Goodman, Max, and Connor Pedersen. "Should the Food and Drug Administration Limit Placebo-Controlled Trials?" Voices in Bioethics 8 (July 8, 2022). http://dx.doi.org/10.52214/vib.v8i.9639.

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Photo by Diana Polekhina on Unsplash ABSTRACT Randomized placebo-controlled trials are often used in clinical research, though there are ethical concerns regarding their use. The Food and Drug Administration (FDA) has rejected international stances on placebo-controlled trial use in favor of the bioethical principles of autonomy, beneficence, nonmaleficence, and justice. The FDA permits placebo-controlled trials in three circumstances: when there are no established treatments available when their use would be of negligible harm to the patient, and when there are compelling reasons for their use. However, in some cases, the FDA’s approval of placebo-controlled trials violates bioethical principles. Ultimately, the FDA should overhaul its practices regarding the use of placebo-controlled trials. INTRODUCTION Randomized placebo-controlled clinical trials (PCTs) are considered the most rigorous method of understanding the efficacy of an intervention and, as a result, are widely used in clinical research.[1] However, there are ethical concerns regarding placebo controls, including their use in the study of deadly diseases or when effective treatments already exist, though poor oversight and lax rules have largely permitted PCT research, even under those conditions.[2] The FDA prefers PCTs for most interventional research and considers them essential to test the efficacy of drugs. Between 2006-2011, 40 percent of FDA-approved clinical trials used a placebo alone for comparison. The FDA has been lagging in altering its policies regarding PCTs, only advising against PCT research in select oncological cases for the first time in 2019 in a nonbinding guidance. It is our belief that the FDA should change its approach and prohibit the use of placebo controls in clinical trials where effective treatments already exist. l. Brief History of PCTs and the FDA In contemporary research practices, PCTs are used to evaluate whether an intervention is effective by comparing it to a control group that received a treatment designed to have no real effect (placebo). Throughout the 20th century there have been numerous bioethical tragedies, including but not limited to the Holocaust and the Tuskegee Syphilis Study.[3] These and other transgressions have become an impetus for establishing ethical research standards preventing human exploitation in the name of science. The Declaration of Helsinki, adopted in 1964, a nonbinding instrument, restricts the use of PCTs. Clause 33 of the Declaration of Helsinki states that new medical interventions should be tested against previously demonstrated interventions and placebos should be used only if there is no existing intervention with narrow exceptions. Clause 33 says the effectiveness of a new intervention must be tested against those of the best current proven intervention (s), except in the following circumstances: Where no proven intervention exists, the use of placebo, or no intervention, is acceptable; or Where for compelling and scientifically sound methodological reasons the use of any intervention less effective than the best proven one, the use of placebo, or no intervention is necessary to determine the efficacy or safety of an intervention and the patients who receive any intervention less effective than the best proven one, placebo, or no intervention will not be subject to additional risks of serious or irreversible harm as a result of not receiving the best proven intervention. Extreme care must be taken to avoid abuse of this option.[4] The FDA has largely ignored this and deemed placebo controls the gold standard, stating that “PCTs are necessary to control for placebo effect of investigational medicinal product.”[5] The FDA has even refused to approve drugs that are tested against established treatments instead of against placebos, notably atenolol.[6] By stretching the “methodological” exception and failing to define harm reasonably, the FDA does not meet the spirit behind Helsinki’s conditions for allowing PCTs. When the Declaration of Helsinki was revised in 2000 to increase restrictions, the Director of Medical Policy for the FDA’s Center for Drug Evaluation and Research considered it “unpardonable” and abandoned any compliance with it in 2008.[7] The FDA’s past statements and actions have supported its belief that drug approval hinges on the use of placebos. While the FDA has rejected the Declaration of Helsinki’s stance on placebos, it has remained faithful to the guidelines of other bioethical codes such as the International Ethical Guidelines for Biomedical Research Involving Human Subjects and the Council for International Organization of Medical Science’s guidelines for biomedical research involving human subjects. The International Ethical Guidelines for Biomedical Research Involving Human Subjects permits PCTs if the consequences are negligible, when methodologically advantageous, and when responses have been historically erratic.[8] The Council for International Organization of Medical Science’s guidelines for biomedical research involving human subjects echoed the Declaration of Helsinki in guideline 11, stating that a “‘placebo may be used: When there is no effective intervention; when withholding an established, effective intervention would expose to, at most temporary discomfort, or delay in relief symptoms; when use of an established, effective intervention as comparator would not yield scientifically reliable results and the use of the placebo would not add risk of serious or irreversible harm to subjects.”[9] The Belmont Report notes three ethical principles: beneficence, respect for persons (autonomy), and justice. The Common Rule requires IRBs for human research and reflects principles noted in the Belmont Report. The Belmont Report covers three applications of its principles: Informed consent, selection of research subjects, and risk-benefit assessments.[10] In 1979, Beauchamp and Childress established the four principles approach to bioethics including autonomy, beneficence, nonmaleficence, and justice. While PCTs were not mentioned in these reports, the principles in them permit placebo controls as long as subjects are informed of the risks of participating and risks are minimized. The FDA has since followed that approach. These guidelines have made PCTs ethically ambiguous, and there are moral counterpoints to be made. ll. FDA-PCT Conditions The FDA has permitted PCT use under three conditions. The first condition is when there is no proven intervention for the medical condition under the study. This means treatment has either not been found for a disease or has not yet been translated into clinical practice and is not controversial. The second condition is when there is negligible harm to the patient from delaying or forgoing an available treatment. In this scenario, a placebo is not suspected to cause damage and the available treatment is meant for mild conditions that pose low-risk adverse effects, which is said to justify its use. The final condition is when there are compelling methodologic reasons for the use of the placebo. This scenario is for situations where outcomes fluctuate for complex reasons making other research methods likely to be unreliable. This condition for PCT use is also justified when it is not possible to administer the intervention to the experimental group because of economic, social, or administrative factors, in which case it is believed to be better to have results of some kind than none at all.[11] We will argue each condition is unethical to the current degree it is practiced. lll. Condition One: Lack of Established Treatment Placebo use in cases where no established treatment exists would not typically be considered unethical. However, placebos continue to be used in numerous clinical trials approved by the FDA, many of which already have standard interventions.[12] In addition, the lack of head-to-head drug trials, in favor of placebo, has had no benefit on clinical guidelines and practices. The direct comparison of drugs in head-to-head trials gives physicians and buyers a better understanding of the effectiveness of a drug and allows for the creation of more robust clinical guidelines. Instead, under the PCT model, the market is saturated with a plethora of drugs to choose from. While each one may be better than placebo, it can be difficult to understand how each treatment compares to another, which may be harmful to patients. A recent study has shown that nearly 90 percent of new drugs do not perform better than existing options.[13] There is an ethical cost to be considered when devoting financial resources and effort to create new drugs that are inferior to existing treatments and have not led to changes to clinical practice. While the FDA claims to follow the bioethical principles of beneficence and nonmaleficence, its choice of approving treatments through placebo controls, despite the existence of standard interventions, counters these guidelines. lV. Condition Two: Negligible Harm from Delayed Treatment The International Ethical Guidelines for Biomedical Research Involving Human Subjects argues that placebos are acceptable if there is only “temporary discomfort or a delay in relief of symptoms,” a stipulation that the FDA follows. However, what constitutes temporary is arbitrary, as there is no absolute reference of time prescribed, nor is there a defined proportion relative to total life expectancy available. For example, many patients in trials for terminal illnesses have a limited therapeutic window and a reduced life expectancy, so they value time differently from someone with a non-terminal illness. Additionally, there is no consensus of what constitutes harm when withholding treatment; placebos are often used in trials for major depressive disorder, yet this population has statistically higher rates of self-harm and suicide without treatment compared to the general population.[14] Serious risks can be incurred due to a placebo intervention by not offering experimental treatment, without excusing the psychological harm withholding a treatment may have on a patient should it be unblinded. Nevertheless, the FDA has used the umbrella term of “temporary discomfort” to justify the widespread use of PCTs, but the vagueness of this language results in human suffering. V. Condition Three: Compelling Methodological Reasoning Finally, the FDA authorizes placebo use in cases where for compelling scientifically sound methodological reasons, the use of placebo is necessary to determine the efficacy or safety of an intervention, and the parties who receive placebo or no treatment will not be subject to any risk of serious or irreversible harm. The condition includes cases where PCT is believed to be necessary to demonstrate efficacy, such as in trials of psychoactive drugs where evidence is inconsistent due to disease heterogeneity and demonstrating equivalence to an established treatment is insufficient. There are also arguments that PCTs, while not necessary, may be beneficial in generating socially valuable knowledge. However, whether a placebo control demonstrates efficacy is not sufficient to justify its use. When considering the ethical use of PCTs, investigators must weigh the social value gained against the risks of no treatment in the control. Unfortunately, the risk-benefit analysis is often controversial. For example, in 2001, the FDA initially responded positively to a placebo-controlled trial of Surfaxin in infants with acute respiratory distress syndrome in Latin America. However, the trial was deemed exploitative by a public watch group when it was revealed that the drug was already FDA-approved in the United States, and the manufacturer of that drug was undertaking another study with the same drug in Europe without any placebos. To justify withholding treatment from a vulnerable population in a developing country, the manufacturer stated that they would be providing a drug that would otherwise be unavailable to many participants, and the risks would be compensated by upgrades to the host country’s medical infrastructure. Despite the FDA’s initial approval and the manufacturer’s attempt to quell public outcry, objections by the public led to the removal of the placebo arm from the trial. While the FDA believes there may be methodologically compelling reasons to utilize PCTs, they have demonstrated a lack of judgment necessary to balance the gains against their inherent losses, requiring the public to step in. CONCLUSION Based on the ambiguous bioethical guidelines that the FDA follows, and the moral justifications described in this paper, its preference of PCTs is unethical. We suspect the overreliance of PCTs has resulted in harm to research participants and the general population, which is why the FDA should change its policy. We propose that PCTs be used only for diseases that lack an established treatment, as decreed by Clause 33 of the Declaration of Helsinki. Other measures that would satisfy Clause 33, the Belmont Report, and the Common Rule are the use of large retrospective observational trials for comparison rather than a prospective placebo group. Ultimately, it is ethically necessary that the FDA modify its practices regarding drug approval and more stringently scrutinize PCTs as well as adopt more favorable approaches to other comparative models. Acknowledgments We sincerely thank Dr. Gregory James Smith, JD, DBE for his patience and guidance in both the research and writing of this paper. - [1] Simmonds A. Ethics of placebo-controlled trials in developing countries: The Search for Standards and Solutions. The Morningside Review. https://journals.library.columbia.edu/index.php/TMR/article/view/5507. Published May 1, 2011. Accessed April 21, 2022; Millum J, Grady C. The ethics of placebo-controlled trials: Methodological Justifications. Contemporary Clinical Trials. 2013;36(2):510-514. doi:10.1016/j.cct.2013.09.003; Center for Drug Evaluation and Research. Institutional Review Boards (IRBs) and Protection of Human Subjects in Clinical Trials. U.S. Food and Drug Administration. https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/institutional-review-boards-irbs-and-protection-human-subjects-clinical-trials. Published September 11, 2019. Accessed April 21, 2022. [2] Keränen T, Halkoaho A, Itkonen E, Pietilä A-M. Placebo-controlled clinical trials: How trial documents justify the use of randomisation and Placebo. BMC Medical Ethics. 2015;16(1). doi:10.1186/1472-6939-16-2; Feifel D. The use of placebo-controlled clinical trials for the approval of psychiatric drugs: part I-statistics and the case for the "greater good.” Psychiatry (Edgmont). 2009;6(3):41-43; van der Graaf R, Rid A. Placebo-controlled trials, ethics of. International Encyclopedia of the Social & Behavioral Sciences. 2015:164-173. doi:10.1016/b978-0-08-097086-8.11011-6; Ibrahim MS, Ovosi JO, Bello-Ovosi BO. Randomized controlled trials: Ethical and scientific issues in the choice of placebo or active control. Annals of African Medicine. 2017;16(3):97-100. doi:10.4103/aam.aam_211_16; Sorscher S, AbuDagga A, Almashat S, Carome M, Wolfe S. Placebo-only-controlled versus active-controlled trials of new drugs for nine common life-threatening diseases. Open Access Journal of Clinical Trials. 2018;Volume 10:19-28. doi:10.2147/oajct.s156054; Mezher M. FDA finalizes guidance on placebos and blinding for cancer trials. Regulatory Affairs Professionals Society (RAPS). http://www.raps.org/news-and-articles/news-articles/2019/8/fda-finalizes-guidance-on-placebos-and-blinding-fo. Published August 28, 2019. Accessed April 21, 2022. [3] WMA Declaration of Helsinki – ethical principles for medical research involving human subjects. The World Medical Association. http://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/. Published July 9, 2018. Accessed April 21, 2022. [4] WMA Declaration of Helsinki, Clause 33. [5] Ovosi JO, Ibrahim MS, Bello-Ovosi BO. Randomized controlled trials: Ethical and scientific issues in the choice of placebo or active control. Ann Afr Med. 2017;16(3):97-100. doi:10.4103/aam.aam_211_16; Rothman KJ, Michels KB. The continuing unethical use of placebo controls. New England Journal of Medicine. 1994;331(6):394-398. doi:10.1056/nejm199408113310611 [6] Rothman KJ, Michels KB. The Continuing Unethical Use of Placebo Controls. New England Journal of Medicine.1994;331(6):394-98. doi:10.1056/nejm199408113310611 [7] Hollon T. FDA uneasy about placebo revision. Nature Medicine. 2001;7(1):7-7. doi:10.1038/83389 [8] International Ethical Guidelines for Biomedical Research Involving Human Subjects. Geneva: CIOMS; 1993. https://cioms.ch/wp-content/uploads/2017/01/WEB-CIOMS-EthicalGuidelines.pdf. Accessed April 21, 2022. [9] Ovosi JO, Ibrahim MS, Bello-Ovosi BO. Randomized controlled trials: Ethical and scientific issues in the choice of placebo or active control. Ann Afr Med. 2017;16(3):97-100. doi:10.4103/aam.aam_211_16 [10] The Belmont Report Ethical Principles and Guidelines for the Protection of Human Subjects of Research. Washington, D.C: U.S. Government Print. Off; 1978. Accessed April 21, 2022. Office for Human Research Protections (OHRP); Federal Policy for the Protection of Human Subjects ('Common Rule'). HHS.gov. https://www.hhs.gov/ohrp/regulations-and-policy/regulations/common-rule/index.html. Published June 16, 2021. Accessed April 21, 2022. [11] Millum J, Grady C. The ethics of placebo-controlled trials: Methodological justifications. Contemporary Clinical Trials. 2013;36(2):510-514. doi:10.1016/j.cct.2013.09.003; Center for Drug Evaluation and Research. Institutional Review Boards (IRBs) and Protection of Human Subjects in Clinical Trials. U.S. Food and Drug Administration. https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/institutional-review-boards-irbs-and-protection-human-subjects-clinical-trials. Published September 11, 2019. Accessed April 21, 2022. [12] Center for Drug Evaluation and Research. New drug therapy approvals 2020. U.S. Food and Drug Administration. https://www.fda.gov/drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products/new-drug-therapy-approvals-2020#first-in-class. Published January 8, 2021. Accessed April 21, 2022. [13] Light DW, Lexchin J, Darrow JJ. Institutional corruption of pharmaceuticals and the myth of safe and effective drugs. Journal of Law, Medicine & Ethics. 2013;41(3):590-600. doi:10.1111/jlme.12068 [14] Lahey T. The ethics of clinical research in low- and middle-income countries. Ethical and Legal Issues in Neurology. 2013:301-313. doi:10.1016/b978-0-444-53501-6.00025-1
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