Dissertations / Theses on the topic 'Later stage development'
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Favato, Giampiero. "Parametric cost analysis of late-stage pharmaceutical development." Thesis, Brunel University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488727.
Full textValentine, Gareth J. "Development of all-solid-state modelocked laser sources at 1.55 μM." Thesis, University of St Andrews, 1999. http://hdl.handle.net/10023/14790.
Full textSardana, Malvika. "Development of New Late-Stage Labeling Methods with Labeled Carbon and Fluorine-18." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASF001.
Full textIsotope labeling is a crucial tool in drug discovery. Therefore, expanding the toolbox of a radiochemist with methods that allow late-stage labeling is highly important. The work presented in this thesis describes the development and utilization of late-stage labeling methods with carbon and fluorine. Carbonylation reactions with carbon monoxide are particularly known as mild and compatible with the late-stage labeling. The first part of the thesis describes the development of visible-light mediated palladium-catalysis using alkyl iodides as the coupling partner for the carbonylation. The mild and versatile radical aminocarbonylation protocol has shown good substrate compatibility. The use of 9-Methylfluorene-9-carbonyl chloride (COgen) allowed easy translation between unlabeled and labeled reaction. In order to bypass the synthesis of COgen which proceeds in two steps plus one step for the liberation of CO, we focused our efforts towards the one step reduction of labeled CO₂ to labeled CO using disilanes catalyzed by fluorides. The last part of this thesis discusses the development of a new positron emission tomography (PET) radiotracer for P-glycoprotein (P-gp), an active transporter at the blood-brain barrier. Crizotinib is an approved treatment for non-small cell lung carcinoma and its brain accumulation is restricted by P-gp. Crizotinib was successfully labeled with ¹⁸F, and rodent studies to map P-gp and improve the delivery of crizotinib to the brain are ongoing
Canelli, Tommaso. "Development of tandem C-H borylation/functionalization procedures for late stage functionalization of compounds." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9273/.
Full textKim, Chan Kyu. "Development of bio-photonic sensor based on laser-induced fluorescence." Diss., Mississippi State : Mississippi State University, 2007. http://library.msstate.edu/etd/show.asp?etd=etd-11052007-092200.
Full textPrasankumar, Rohit Prativadi 1975. "Development and application of saturable absorbers to femtosecond solid-state laser mode-locking." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/29620.
Full textIncludes bibliographical references (p. 209-228).
Semiconductor saturable absorbers have had a major impact on the field of ultrashort pulse generation by increasing the stability and reliability of ultrashort pulse lasers, making them more useful in many applications. These versatile devices can be grown both epitaxially with molecular beam epitaxy and non-epitaxially using RF sputtering. In this thesis, the development and application of both types of saturable absorbers to self-starting mode-locking in solid-state lasers was examined. The first part of this thesis describes the use of an epitaxially grown saturable Bragg reflector to mode-lock an extended cavity femtosecond Cr:LiSAF laser. Inexpensive single mode diodes were used as a pump source and a multi-pass cavity was used to lower the laser repetition rate. Pulses with durations of 39 fs and energies of 0.75 nJ were generated at an 8.6 MHz repetition rate. These pulse energies and durations are comparable to those produced from commercially available Ti:sapphire lasers that have a significantly higher cost. The second part of this thesis explored the further development and application of non-epitaxially grown semiconductor-doped silica films. A novel pump-probe system with independent pump and probe wavelength tunability from 700 to 1000 nm and a time resolution of 17 fs was developed for device characterization. The linear and nonlinear optical properties of InAs-doped silica films deposited by RF sputtering were characterized as a function of fabrication parameters, including nanocrystallite size, pump and probe wavelength relative to the absorption edge, and rapid thermal annealing temperature. Guidelines for the optimization of semiconductor-doped silica films for saturable absorber applications were extracted from the experimental data.
(cont.) Large nanocrystallites, high annealing temperatures, and an operating wavelength close to the absorption edge were found to optimize saturable absorber performance, with a low saturation fluence of 640 pJ/cm2 obtained at 1.54 grm. These saturable absorber devices were then designed to self-start mode-locking in a Cr:forsterite laser, obtaining self-starting 25 fs pulses with 91 nm bandwidth at 1.3 gm. These versatile devices can be designed for any solid-state laser system using the guidelines developed in this work and have the potential to replace epitaxially grown saturable absorbers in many applications.
by Rohit Prativadi Prasankumar.
Ph.D.
Mujahid, Hana, Ken Pendarvis, Joseph Reddy, Babi Nallamilli, K. Reddy, Bindu Nanduri, and Zhaohua Peng. "Comparative Proteomic Analysis of Cotton Fiber Development and Protein Extraction Method Comparison in Late Stage Fibers." MDPI AG, 2016. http://hdl.handle.net/10150/618719.
Full textStehmann, Timo. "Development and optimisation of a solid-state pulsed power supply for a CO₂ TEA laser." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53359.
Full textENGLISH ABSTRACT: With technological advances in solid-state switches the modernization of conventional pulsed power supplies utilizing thyratrons has become possible. A novel pulsed power supply is designed where two series-stacked IGBTs (rated at 1700 V and 300 A each) are used to replace a thryatrondriven pulsed power supply for a mini CO2 TEA laser. The mini CO2 TEA laser is firstly characterized in order to optimize the design of the pulsed power supply. It is found that stable laser discharges can be obtained with electrode voltage rise-times of 150 ns or less. Furthermore, the optical output energy and the efficiency of the laser have been significantly increased by reducing the peaking capacitor size of the pulsed power supply. The two stacked IGBTs switch a C-C transfer loop and the generated pulse is stepped up by a pulse transformer and is compressed by a two-stage magnetic pulse compression unit. Theoretically and through measurements it is shown that automatic voltage sharing between the two IGBTs can be obtained if the turn-on time of the IGBTs is much faster than the transfer time of the switched C-C transfer loop. Lifetime tests reveal that high-power IGBTs are able to reliably switch pulses with peak currents between 4 and 5 times the rated average current of the device. Under laser fault conditions, i.e. laser arcing or missing laser discharges, the reliability of the pulser can be increased by using over-voltage snubbers. In addition, it was found that the internal diode of IGBT modules can eventually fail under the prevalence of laser fault conditions. A modular construction approach is used where components of the pulsed power supply are preassembled. A new rectangular layout of the magnetic pulse compression unit is utilized in order to minimize size and simplify the final construction and assembly.
AFRIKAANSE OPSOMMING: Nuwe ontwikkeling in vastetoestand-skakelaars het die modernisering van laser-pulskragbronne moontlik gemaak. ’n Nuwe kragbron wat gebruik maak van twee seriegeskakelde IGBT’s is ontwerp om ’n Tiratron-gedrewe laserkragbron te vervang, wat vir ’n mini-C02-TEA-laser gebruik word. Die laser is vooraf eers gekarakteriseer om sodoende die laserkragbron te optimeer. Daar is bevind dat stabiele laserontladings verkry kan word met spanningstygtye van 150 ns of minder. Verder kan die uittree-energie van die laser beduidend verhoog word deur die uittreekapasitore (eng.: peaking capacitors) van die laserkragbron te verminder. Die twee serie-geskakelde IGBT’s skakel ’n C-C oordraglus. Die spanning van die gegenereerde puls word deur ’n pulstransformator verhoog en die stygtyd van die puls word met ’n twee-stadium magnetiese pulskompressor verlaag. Teoreties en deur metings kan getoon word dat eweredige spanningsverdeling tussen die twee IGBT’s outomaties verkry kan word indien die skakeltye van die IGBT’s baie vinniger as die oordragstyd van die C-C oordraglus is. Toetse het getoon dat IGBT’s pulse met piekstrome van tussen vier tot vyf keer die gespesifiseerde gemiddelde stroom betroubaar kan skakel. Tydens laserfouttoestande kan die betroubaarheid van die IGBT verhoog word deur oorspanningsgapsers te gebruik, maar onder fouttoestande wat voortduur, kan die IGBT se interne diode vemietig word. Die komponente van die laserkragbron is as modules vervaardig, wat op ’n maklike wyse gemonteer kan word. ’n Nuwe reghoekige uitleg is gebruik vir die konstruksie van die magnetiese pulskompressor, waarmee die grootte van die pulskompressor geminimeer en die konstruksie vergemaklik is.
Kirilov, Emil. "Development of necessary ion traps, vacuum and laser systems for photoionization, laser cooling and quantum state engineering of trapped Strontium ions." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1481672311&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Full textMatos, Carolina Thieleke da Silva Macedo. "Interaction of malaria parasites with host late endocytic and autophagic pathways is essential for Plasmodium liver stage development." Doctoral thesis, Faculdade de Ciências Médicas, 2013. http://hdl.handle.net/10362/12157.
Full textHageman, William. "THE DEVELOPMENT OF SCALABLE PUMP TECHNIQUES FOR GG IAG FIBER LASERS AND PASSIVE ATHERMALIZATION TECHNIQUES FOR SOLID STATE LASER." Doctoral diss., University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3639.
Full textPh.D.
Optics and Photonics
Optics and Photonics
Optics PhD
Paul, Thomas Alfred. "Development and spectroscopic applications of a solid-state vacuum ultraviolet laser system in atomic and molecular physics /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17814.
Full textGottschalk, Adrian Hedley Benjamin 1975. "Improving the efficiency of the later stages of the drug development process : survey results from the industry, academia, and the FDA." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/16699.
Full textIncludes bibliographical references (p. 65).
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Drug development in the United States is a lengthy and expensive endeavor. It is estimated that average development times range from eleven to fifteen years and exceed costs of one billion dollars. The development pathway includes basic scientific discovery, pre-clinical testing in animals, clinical development in humans, and an application process. The Food and Drug Administration is responsible for the oversight and approval of drugs going through this process. Numerous financial and economic studies have been conducted that show the benefits to accelerating the drug development process. In 1992, the United States Congress enacted the Prescription Drug User Fee Act I, which mandated faster response times from the FDA in return for user fee payments to the FDA by the drug developing companies. Data on approval times for new drugs indicate that this process was indeed shortened. In contrast, the average drug development process prior to the filing of an application has been increasing in cost and time. The first purpose of this research is to quantify the benefits of accelerated new drug application review time under the Prescription Drug User Fee Acts I and II. The second purpose of the research is to investigate what industry and the FDA can do together to reduce the development process time between the IND and NDA without compromising patient safety and welfare, specifically the Phase II, Phase III, and NDA components. The research indicates that PDUFA has improved approval times in a statistically significant way. Furthermore, the financial and social benefits as measured using net present value have far exceeded the PDUFA costs. Quantitative and qualitative surveys of fifty individuals in large pharmaceutical and biotech companies
(cont.) resulted in the identification of several significant opportunities and useful suggestions for reducing development times in Phase II, Phase III, and the NDA. Specifically, company interviewees indicated that they were willing to pay additional monies for increased interaction and communication with the FDA from Phase II through the NDA in hopes of reducing information asymmetry and increasing information transparency. Other recommendations included a mandatory audit and review of a sample of NDAs post approval to identify best practices, implementation of metrics and performance tracking during clinical phases, and implementation of consistent project management and communication standards across therapeutic divisions.
by Adrian Hedley Benjamin Gottschalk.
S.M.
Black, Juli. "Developmental Patterns of Metabolism and Hematology in the Late Stage Chicken Embryo (Gallus Domesticus) at Two Incubation Temperatures." Thesis, University of North Texas, 2003. https://digital.library.unt.edu/ark:/67531/metadc6150/.
Full textThurlow, Meghan Elizabeth. "Free Radicals and Reactive Intermediates in the Boundary Layer: Development and Deployment of Solid-State Laser Based Instrumentation to Measure Part per Trillion Mixing Ratios of Iodine Monoxide and Glyoxal In Situ." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10668.
Full textChemistry and Chemical Biology
Lemes, Hamawaki Raphael. "EVALUATION OF DI-NITROGEN FIXATION IN EARLY AND LATE DEVELOPMENTAL STAGES OF SOYBEAN (Glycine max [L.] Merr.)." OpenSIUC, 2018. https://opensiuc.lib.siu.edu/dissertations/1592.
Full textOsborne, Jason Matthew. "The development of church/state relations in the Visigothic Kingdom during the sixth century (507-601)." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3156.
Full textLee, Daphnee Hui Lin. "From Cradle to Playpen: the management of Chineseness in developmental state Singapore." Phd thesis, Canberra, ACT : The Australian National University, 2010. http://hdl.handle.net/1885/49385.
Full textNogueira, Gustavo Bernardes. "Desenvolvimento de lasers no azul, a partir da geração de segundo harmônico de um laser de Nd:YAG operando em 946 nm." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-08112010-165940/.
Full textBlue lasers have attracted much attention for applications such as blu-ray, displays and as pumped source for the Ti:sapphire laser. A Nd:YAG crystal with diffusion bonded end-caps was used together with a pump wavelength of 802,3 nm, detuned from the absorption peak at 808 nm in order to minimize the thermal lens effect by providing for a better temperature distribution inside the crystal. Using different input mirror radii, the best relation between pump waist and laser was achieved in a linear cavity and resulted in 6.75W cw (continuous wave ) laser power at 946 nm and slope efficiency of 48%. In a second step, a second harmonic generation crystal for blue emission at 473 nm was inserted into different types of resonators, and the blue output power at 473 nm was measured as a function of absorbed pump power.
Rethwisch, M. D., M. Reay, G. Chaffin, R. Perez, J. Grudovich, J. Wellman, and E. Hawpe. "Late Planted DPL451BR Cotton Responses to Plant Growth Enhancement Products Applied at Three Crop Development Stages in Palo Verde Valley, 2003." College of Agriculture, University of Arizona (Tucson, AZ), 2004. http://hdl.handle.net/10150/198128.
Full textStewart, Brian K. "Development of a Thin-Film Evaporative Cooling System for a High Energy Thulium Holmium: Lutetium Lithium Flouride Solid-State Laser Oscillator Crystal." Thesis, Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/6973.
Full textStewart, Brian K. "Development of a thin-film evaporative cooling system for a high energy thulium holmium lutetium lithium fluoride solid-state laser oscillator crystal /." Available online, Georgia Institute of Technology, 2005, 2004. http://etd.gatech.edu/theses/available/etd-12032004-114711/unrestricted/stewart%5Fbrian%5Fk%5F200505%5Fmast.pdf.
Full textS. Mostafa Ghiaasiaan, Committee Chair ; Sheldon M. Jeter, Committee Member ; Said I. Abdel-Khalik, Committee Member. Includes bibliographical references.
Quach, Judy Tinh Nhi. "The validity of the Modified Ordinal Scales of Psychological Development (M-OSPD) for use with people in late stages of Alzheimer disease." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0015/MQ47084.pdf.
Full textPetrova-Mayor, Anna. "Development of an eye-safe solid-state tunable laser transmitter around 1.45 my m based on Cr 4+:YAG crystal for lidar applications." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:100-opus-2782.
Full textBERECZKI, ALLAN. "Desenvolvimento de um laser DPSSL polarizado com mais de 100 W de potência e parâmetro de qualidade próximo de um." reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26822.
Full textMade available in DSpace on 2016-11-11T16:24:00Z (GMT). No. of bitstreams: 0
A operação dinamicamente estável com zonas conjuntas foi obtida para um ressonador laser contendo dois bastões de Nd:YAG com módulos laser comerciais. O ressonador não polarizado gerou 115 W de potência no modo transversal fundamental TEM00. Quando polarizado por lâmina de Brewster atingiu 100,5W de potência de saída com 91% de polarização. Quando o ressonador foi polarizado com um polarizador de filme fino, obteve-se melhora na qualidade de feixe e um aumento na polarização, com o valor de M2 sendo 1,56 e 1,84 nas direções x e y respectivamente com 95,4% de polarização. A potência de saída foi, ao nosso conhecimento, a mais alta obtida para lasers polarizados operando no modo fundamental e usando módulos lasers comerciais de Nd:YAG bombeados lateralmente por diodos sem nenhuma preparação especial.
Dissertação (Mestrado em Tecnologia Nuclear)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
Velissariou, Panagiotis. "Development of a Coastal Prediction System That Incorporates Full 3D Wave-Current Interactions on the Mean Flow and the Scalar Transport With Initial Application to the Lake Michigan Turbidity Plume." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1229959016.
Full textMahadevan, Pradeep. "Analysis of layer development and fusing for 3D laser printing." 2003. http://www.lib.ncsu.edu/theses/available/etd-05062003-080231/unrestricted/etd.pdf.
Full textWang, Yu-Siang, and 王昱翔. "Development of Laser Direct Writing Equipment of Nano Stage." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/46755r.
Full text國立虎尾科技大學
機械與機電工程研究所
99
This research project in title of “Laser Direct Writing Processing Equipment for Periodic Nanostructure Pattern” integrated the technologies of the hybrid long-stroke precision nano-stage design, the multi-DOF heterodyne interferometer feedback control system, and the novel laser direct writing lithography instrument. The hybrid long-stroke multi-axis precision nano-stage formed by an H-type long-stroke nano-stage and a nano piezo-stage. The multi-DOF heterodyne interferometer feedback control system uses dual-frequency laser interferometer for the measurement of X and Y axis position and θz angle error of the nano-stage. The ovel laser direct writing lithography instrument includes blue laser direct writing head, FPGA interface and servo control main board. Finally, the system integration and relevant tests have been completed as well. This equipment have been working to generate increase writing speed, precision and range. In this research, the integration of the Laser Direct Writing Processing Equipment can improve the process speed, precision and range, overcome the optical limit of interference to reduce the writing spot, generate arbitrary patterns, and cut down the equipment cost.
Yu-Tsung and 李育宗. "Development of 266nm all Solid-State Laser." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/63240538479794183153.
Full text國立中山大學
物理學系
87
Solid state lasers possess unique status in the history of laser development. In 1960's, the first laser successfully developed laser is a solid state ruby laser. Despite of solid-state lasers' limited coverage of optical spectrum, they have several advantages, such as long life time, high stability, and high conversion efficiency. Extending available wavelengths of solid state lasers is one of the major on-going efforts of photonic community. In this dissertation, resonant enhanced second harmonic generation (SHG) in a BBO nonlinear optical crystal is employed to convert the output of a diode-pumped solid state laser at 532 nm into 266nm. We have built both the theoretical model and the experimental setup to realize a continuous wave ultraviolet laser. Coupling efficiency as high as 93% is demonstrated.
Vincent, Nicola Caroline. "Evolving consciousness in leaders: promoting late-stage conventional and post-conventional development." Thesis, 2014. http://hdl.handle.net/2440/87864.
Full textThesis (Ph.D.) -- University of Adelaide, School of Psychology, 2014
Yang, Hao-Wen, and 楊皓文. "Development of a Sequential Two-stage Layer Forming Rapid Prototyping Machine." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/25181023587143341472.
Full text國立成功大學
機械工程學系碩博士班
94
The Rapid Prototyping (R.P.) technology which is generally used to manufacturing a three-dimensional solid part is based on the layer forming method. The R.P. technology had been devised in 1978 and its advantages are easy to achieve the purposes of saving time and cost. In recent years, many kinds of commercially available machines are invented successively. However, all the existing R.P. devices had some faults. Thus, in this thesis, a new type of R.P. process is proposed to improve the quality of the articles and decrease the cost of the current R.P. machines. The process of the new R.P. is called “Sequential Two-stage Layer Forming Process”. The process started from using a spray gun to spread a thin layer of polymeric material on the forming bed, followed by using the two-stage forming method to carry out the layer manufacturing process. Based on the new idea, this thesis had developed, designed and fabricated a brand new machine. With this machine, the concept of the new R.P. machine which is expected to achieve the target of low-cost and fast process is implemented.
WU, JHONG-SYUAN, and 吳鍾萱. "Development of two-stage RF power supply for driving CO2 laser." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/44393100389747264982.
Full text國立聯合大學
光電工程學系碩士班
105
In this thesis, we propose a two-stage RF power supply that drives carbon dioxide laser. The power supply is based on Metal Oxide Semiconductor Field-Effect Transistor(MOSFET). RF power supply is combine with one stage oscillator and one stage amplifier. We apply MRF148 with our oscillator. The oscillation frequency is 100MHz. Maximum power is up to 30W in output continuous wave and peak power have 35W. In two stage of amplifier we use MRF150 and design push-pull structure of amplifier. The purpose is reduce the series of high-power RF power supply and circuit size. The maximum output is up to 300 W and efficiency is 78.5%. The standing wave ratio is 1:2. In our control circuit part we combine Pulse Width Modulation(SG3525), optical coupler(TPL250) and high side driver(IR2117). We use Pulse Width Modulation to control oscillator signal, then amplified by a push-pull amplifier. The result of high-power RF signal to stimulate carbon dioxide laser. When gas dissociation, we observe the gas discharge of carbon dioxide.
Liou, Sing-Yan, and 劉興諺. "Development of New Type Linear Stage with Double-Layer Throttling Porous Aerostatic Bearing." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/54342974701647728469.
Full text國立勤益科技大學
機械工程系
102
The structure configuration of air flotation platform is usually designed with low gravity center, low geometric error, low fever errors and symmetrical structure. Especially, the mobile component is mostly made of lightweight aluminum to reach a low inertia for high precision and high speed motion control. As a consequence, the linear stage with air bearing has been widely used in the fields of optical instruments, precision medical equipment, semiconductors, subtle elements etc. Such a stage also greatly adopted in precision optoelectronic semiconductor process equipment or testing equipment. This study was aimed to design a high precision aerostatic linear stage based on the newly developed double-layer throttling porous aerostatic bearing, which was created by GMT company collaborated with Metal Industries Research and Development Centre. The mobile platform was made of alumina material with the use of ultra-precision diamond machining. A weight reduction 65% of the mobile stage was achieved due to the use of structural material of alumina alloy, instead of the originally steel material. The straightness accuracy of precision linear aerostatic stage was shown to be 0.7 um, which was based on the high accuracy, good surface roughness and lighter components. The geometric accuracy has been proven to be below 1um/100mm and surface roughness below 0.1um. In addition, the other key feature of this stage is the combination of the aerostatic porous double-throttling technology with the microwell array aluminum board, which effectively enhances the rigidity of the loading capacity due to the array of pore distribution and number density to regulating fluid properties. It follows that rigidity was increased by 3.6 times. As a whole, the prototype of the newly designed aerostatic linear stage developed in this study has been demonstrated to show a better performance as expected. It is believed that a more complete linear stage can further be developed based on this prototype. The technology regarding the double-layer throttling porous aerostatic bearing can also be widely applied to develop other precision instruments in the field of manufacturing industry.
Chen, Ching-Nien, and 陳慶年. "Development of a solid-state three-wavelength laser with volume Bragg gratings." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/93288472790227841820.
Full text國立中央大學
光電科學與工程學系
104
Solid-state dual-wavelength lasers were constructed using a Nd:GdVO4 as the gain medium. The output couplers used in these laser cavities were temperature controlled volume Bragg gratings. The gain of the laser cavities was adjusted by changing the temperatures of the VBGs. Temperature adjustment mainly results in thermal expansion of the VBGs, and shifts the corresponding diffraction spectrums, which will then alter the corresponding emission cross section of the laser outputs. Through this method, three dual-wavelength lasers utilizing different emission peaks of the Nd:GdVO4 were realized. The third wavelength was achieved through an additional Nd:YAG and VBG inside the laser cavity.
Dennis, Ryan Shaun. "Development of a localized heat treatment tool for shape memory alloy wires using an Ytterbium fiber laser." 2005. http://www.lib.ncsu.edu/theses/available/etd-05252005-121400/unrestricted/etd.pdf.
Full textKim, Chong Su. "Democracy as romance and satire: democratisation in South Korea by social movements." Thesis, 2011. http://hdl.handle.net/1828/3504.
Full textGraduate
Brannan, Kelly Elizabeth. "The effect of early incubation temperature and late incubation conditions on embryonic development and subsequent broiler performance." 2007. http://www.lib.ncsu.edu/theses/available/etd-11062007-110540/unrestricted/etd.doc.pdf.
Full textKe, Yi-Ting, and 柯懿婷. "Characterization of rice group 3 late embryogenesis abundant (LEA) genes expression during development stages and stresses." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/19841679547631104410.
Full text國立中央大學
生物資訊與系統生物研究所
97
Late embryogenesis abundant (LEA) proteins were initially found in the stage of embryo maturation. According to amino acid sequence similarities and conserved motifs, the LEA proteins can be separated into more than five groups. It is known that abscisic acid (ABA), salt, drought or cold stress can induce expression of the lea genes, conferring stress tolerance to plant cells. LEA proteins have been shown to involve in binding and replacement of water molecule, ion sequestration, maintaining of protein or cell membrane structure, and development regulation. Group 3 LEA proteins are characterized by 11-mer amino acid conserved tandem repeats (TEAAKQKAAET) and considered as the stress proteins. Barley HVA1, a member of group 3 LEA proteins, has been reported that it can improve stress tolerance in transgenic plants. However, its exact physiological functions still remain unclear. In this study we used the sequence BLAST to search Group 3 LEA protein orthologues in rice genome database and identify five lea3-like genes. They are AP004018/BAD19162, AP003381/BAB86507, AC073556/AAL84288, AC098833/AAU43988, AP000836/BAD81113 (gene/protein accession number). Here we were trying to characterize their gene sequence organization and expression patterns during developmental stages and environmental stresses. The results showed that these LEA genes played important roles on regulation of plant growth and response for varied stresses, and tissue-specific expression in root, stem, leaf, and seed. Furthermore, cellular localization analysis of the AP004018-GFP, AP003381-GFP, AC073556-GFP, AC098833-GFP, and AP000836-GFP fusion proteins in onion epidermal cells indicated that rice group 3 LEA proteins could be in nucleus (AP003381, AC073556 under ABA or 4℃ treatment), cytoplasm (AC073556, AC098833 under ABA; AP004018, AC073556, AC098833 under NaCl; AP004018, AC098833 under 4℃ treatment), or membrane structure (AC073556 under ABA and NaCl; AP004018, AP003381, AC073556, and AC098833 under 4℃ treatment ), whereas these fusion proteins localize in either nucleus or cytoplasm under non-stress conditions.
Chen, I.-Cheng, and 陳乙誠. "Development of a Simple Laser Measurement System for The Four-Degree-of-Freedom Geometric Errors Measurement of a Linear Stage." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/09678151406673939196.
Full text國立臺灣科技大學
機械工程系
103
This study aims to develop a simple 4-degree-of-freedom (DOF) automatic optical measuring system which is capable of measuring the horizontal/vertical straightness error and pitch/yaw angular error of a linear stage. The developed measuring system consists of 4 main modules, namely, the motion mechanism module, the optical path unit module, the electrical signal processing and control module and a set of software to integrate the measuring system and to execute the measurement analysis. Based on the user-input measurement parameters, this system can detect the desired straightness and angular deviation simultaneously. Our experimental optical path includes laser diode, beam expander, mirror, focusing lens, beamsplitter and location sensor (DL-10, DL-20). Following the principle of automatic alignment collimator, we can deflect a plane mirror and make laser resource to focus on the location sensor DL-20. Because of the deflection, the laser spot will have change in movement and get the angle difference received by location sensor DL-10. And then, based on the beam-split technique, our system can work on using the same light resource to measure the straightness, for using laser straight-line method to measure the straightness by DL-10. In order to verify the feasibility and performance of our system, we apply a single-axis precise positioning table in several experiments, and compared the result with the counterparts generated by LDDM. The result prove that the horizontal and vertical straightness is and , and the yaw and pitch angular error is less than and , respectively. During 5 minutes operating time, the movement and angle stability is ±0.6μm and ±1 arc⁄sec.
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